While several prominent actresses spoke out on Monday against Mr. Weinstein, Mr. Affleck was one of a small cadre of prominent male figures in Hollywood with ties to Mr. Weinstein who criticized him on Tuesday after the new reports in The Times and The New Yorker.

Matt Damon, Mr. Affleck’s longtime friend and film collaborator, said in an interview with Deadline on Tuesday that he “never saw” Mr. Weinstein harass or abuse women and that he would have put an end to it if he had. Mr. Damon’s and Mr. Affleck’s film careers were kicked off by “Good Will Hunting,” which Mr. Weinstein backed.

“This type of predation happens behind closed doors and out of public view,” Mr. Damon said. “If there was ever an event that I was at, and Harvey was doing this kind of thing and I didn’t see it, then I am so deeply sorry, because I would have stopped it.”

Several directors with close ties to Mr. Weinstein, such as Quentin Tarantino and Robert Rodriguez, have not responded to requests asking them to comment about what it was like to work with him. As for other filmmakers who have worked with the producer, an email to the director Stephen Daldry also received no response; Phyllida Lloyd declined to comment. And a representative for the director James Gray, who has been critical of Mr. Weinstein, said he was in production on a new film and unable to speak on Tuesday. On Wednesday, Mr. Gray said, “I’m horrified by what I have heard and any issues I might have had with Harvey pale in comparison to what these women went through.”

As more women have come forward, questions have swirled over who in Hollywood might have known something and even directly or indirectly enabled him or protected him. Roughly two dozen former assistants and young actresses have said the powerful and widely feared producer routinely asked them to his hotel room under the pretense of talking about roles or work, and then solicited massages while he was naked or wearing a bathrobe, or sexually forced himself on them.

Ms. Paltrow told The Times that when she was 22, Mr. Weinstein invited her to his hotel bedroom for a work meeting and later proposed a massage. She said she had fled in terror and later relayed the incident to her boyfriend at the time, Brad Pitt. Mr. Pitt confirmed that he later confronted Mr. Weinstein at a theater premiere and told him to never touch her again.