Boris Johnson has sensationally resigned from the government in protest at Theresa May’s Chequers deal, triggering the worst crisis of her premiership.

No 10 announced she had “accepted” the resignation of the Foreign Secretary – just 15 hours after David Davis quit as Brexit Secretary.

The second resignation came just 30 minutes before the prime minister had to face the Commons, amid the mounting anger of Leave-backing Tory MPs that the deal struck on Friday is a sell-out.

It is thought that Mr Johnson was furious with briefings that he had signed up to the agreement at Chequers – despite also calling it “a turd”.

Tom Watson, Labours deputy leader, said: “Theresa May’s government is in meltdown. This is complete and utter chaos.

“The country is at a standstill with a divided and shambolic government. The prime minister can't deliver Brexit and has zero authority left.”

Donald Tusk, the European Council president, immediately suggested the twin blow might yet force the UK to rethink leaving the EU altogether.

People's Vote march – demanding vote on final Brexit deal Show all 30 1 / 30 People's Vote march – demanding vote on final Brexit deal People's Vote march – demanding vote on final Brexit deal Mandatory Credit: Photo by Guy Bell/REX (9725259aq) Marching down Whitehall - People's March for a People's Vote on the final Brexit deal. Timed to coincide with the second anniversary of the 2016 referendum it is organised by anti Brexit, pro EU campaigners. People's March for a People's Vote, London, UK - 23 Jun 2018 Guy Bell/REX Rex People's Vote march – demanding vote on final Brexit deal Demonstrators carry banners and flags as they participate in the People's March demanding a People's Vote on the final Brexit deal, in central London on June 23, 2018, the second anniversary of the 2016 referendum. Tens of thousands of people demonstrated in London on Saturday calling for a second vote on Britain's departure from the European Union. / AFP PHOTO / Niklas HALLE'NNIKLAS HALLE'N/AFP/Getty Images NIKLAS HALLE'N AFP/Getty Images People's Vote march – demanding vote on final Brexit deal A young protestor shouts as she takes part in the People's Vote demonstration against Brexit Getty Images People's Vote march – demanding vote on final Brexit deal A woman holds a placard as she joins EU supporters, calling on the government to give Britons a vote on the final Brexit deal, participating in the 'People's Vote' march in central London, Britain June 23, 2018. REUTERS/Henry Nicholls HENRY NICHOLLS Reuters People's Vote march – demanding vote on final Brexit deal epa06833888 Pro-EU demonstrators take part in a People's March anti-Brexit rally in Parliament Square in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal A protester's pro-EU t-shirt EPA People's Vote march – demanding vote on final Brexit deal epa06833892 A pro-EU demonstrator waves a European Flag during a People's March anti-Brexit rally in Parliament Square in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Demonstrators carry banners and flags as they participate in the People's March demanding a People's Vote on the final Brexit deal, in central London on June 23, 2018, the second anniversary of the 2016 referendum. Tens of thousands of people demonstrated in London on Saturday calling for a second vote on Britain's departure from the European Union. / AFP PHOTO / Niklas HALLE'NNIKLAS HALLE'N/AFP/Getty Images NIKLAS HALLE'N AFP/Getty Images People's Vote march – demanding vote on final Brexit deal epa06833960 Tens of thousands of people march through London during a People's March anti-Brexit demonstration in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Leader of the Liberal Democrats, Vince Cable speaks during the People's March demanding a People's Vote on the final Brexit deal, in central London on June 23, 2018, the second anniversary of the 2016 referendum. Tens of thousands of people demonstrated in London on Saturday calling for a second vote on Britain's departure from the European Union. / AFP PHOTO / Niklas HALLE'NNIKLAS HALLE'N/AFP/Getty Images NIKLAS HALLE'N AFP/Getty People's Vote march – demanding vote on final Brexit deal epa06833964 A young pro-EU demonstrator takes part in a People's March anti-Brexit rally in Parliament Square in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Gina Miller and Caroline Lucas EPA People's Vote march – demanding vote on final Brexit deal epa06834044 Tens of thousands of people march through London during a People's March anti-Brexit demonstration, in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal epa06833264 Thousands of people march through London during a People's March anti Brexit demonstration in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Tens of thousands of people march through London EPA People's Vote march – demanding vote on final Brexit deal epa06833265 Thousands of people march through London during a People's March anti Brexit demonstration in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Demonstrators at the People's Vote March Getty People's Vote march – demanding vote on final Brexit deal 'Two months too young to decide on my future' REUTERS People's Vote march – demanding vote on final Brexit deal Crowds taking part in the People's Vote march for a second EU referendum at Trafalgar Square in central London. PRESS ASSOCIATION Photo. Picture date: Saturday June 23, 2018. See PA story POLITICS Brexit. Photo credit should read: John Stillwell/PA Wire John Stillwell PA People's Vote march – demanding vote on final Brexit deal A young girl joins in the march PA People's Vote march – demanding vote on final Brexit deal An EU flag is draped across the statue of Winston Chruchill in Parliament Square REUTERS People's Vote march – demanding vote on final Brexit deal Demonstrators gather prior to the start of the People's March demanding a People's Vote on the final Brexit deal, in central London on June 23, 2018, on the second anniversary of the 2016 referendum. / AFP PHOTO / Niklas HALLE'NNIKLAS HALLE'N/AFP/Getty Images NIKLAS HALLE'N AFP/Getty Images People's Vote march – demanding vote on final Brexit deal Vince Cable MP, Pro-EU campaigner Gina Miller, Tony Robinson and Caroline Lucas MP join with crowds PA People's Vote march – demanding vote on final Brexit deal Crowds gather on Pall Mall in central London, during the People's Vote march for a second EU referendum. PRESS ASSOCIATION Photo. Picture date: Saturday June 23, 2018. See PA story POLITICS Brexit. Photo credit should read: John Stillwell/PA Wire John Stillwell PA People's Vote march – demanding vote on final Brexit deal Crowds gather on Pall Mall PA People's Vote march – demanding vote on final Brexit deal A man resembling Britain's Foreign Secretary Boris Johnson, joins EU supporters Reuters People's Vote march – demanding vote on final Brexit deal EU supporters, calling on the government to give Britons a vote on the final Brexit deal, participate in the 'People's Vote' march in central London, Britain June 23, 2018. REUTERS/Henry Nicholls HENRY NICHOLLS Reuters People's Vote march – demanding vote on final Brexit deal People gather in Trafalgar Square REUTERS People's Vote march – demanding vote on final Brexit deal Pro-EU campaigner Gina Miller and Tony Robinson PA People's Vote march – demanding vote on final Brexit deal EU supporters, calling on the government to give Britons a vote on the final Brexit deal, participate in the 'People's Vote' march REUTERS

“Politicians come and go but the problems they have created for people remain,” he tweeted. I can only regret that the idea of #Brexit has not left with Davis and Johnson. But...who knows?”

There was also an instant response from Ruth Davidson, the Tory leader in Scotland who has clashed repeatedly with Mr Johnson. She tweeted: “The prime minister is correct to accept the Foreign Secretary's resignation.”

The bookies Ladbrokes immediately rated the prime minister odds-on to be forced out of Downing Street this year – with Michael Gove, the environment secretary, favourite to replace her.

In a terse statement, a Downing Street spokesman said: “This afternoon, the prime minister accepted the resignation of Boris Johnson as Foreign Secretary.

“His replacement will be announced shortly. The prime minister thanks Boris for his work.”

Speculation grew that Mr Johnson was about to quit when he failed to attend a meeting of the government's Cobra emergencies committee, following the fatal Salisbury poisoning.

He also missed a summit of Western Balkan nations being held in London – despite the UK hosting the event as part of attempts to show it would remain a major European player.

Michael Roth, the German Europe minister, tweeted his displeasure, saying: “We’re still waiting for our host....”

In the Commons, there was laughter when the prime minister paid tribute to her “right honourable friends” who had resigned – and shouts of “who’s next?”

Mr Davis was praised for his “hard work’ through two years of negotiations – and Mr Johnson for his “passion” in championing a “global Britain”.

Earlier, the former Brexit Secretary accused Ms May of “giving away too much, too easily” in the Brexit talks, but denied his dramatic resignation was intended to topple her.