Funding information:

This study was supported by research grants of CMRPG2G0651‐3 and CMRPG2E0301 from the Chang Gung Memorial Hospital, Taiwan, and MOST 107‐2314‐B‐182A‐107 of the Ministry of Science and Technology in Taiwan.

Key Message

Fecal butyrate plays an important role in modulating allergic responses to allergens related to asthma. A reduced fecal butyrate is associated with increased mite‐specific IgE levels and the risk of asthma in early childhood. Fecal β‐alanine could be a specific biomarker connecting the metabolic dysbiosis of gut microbiota, Clostridium and Escherichia spp., reducing butyrate production in childhood asthma.