Rosie O'Donnell has reignited her long-running feud with President Donald Trump, by slamming the Commander-in-chief's relationship with his eldest daughter, Ivanka.

Speaking with Michelangelo Signorile on Sirius XM Wednesday, the 57-year-old comedienne shockingly stated: 'There's a creepy incest feel that is very prevalent amongst Donald Trump and his children, at least his daughter [Ivanka].

'I think he's been doing bad things with her for a very long time'.

Never shy in sharing her opinion, O'Donnell then launched a scathing personal attack on Ivanka herself, questioning her capacity as an official advisor to the President.

'I think she's like, a talentless, non-intelligent, non-powerful woman,' the former host of The View declared.

'It's laughable to think of her [Ivanka] in any kind of public service role. No one in his family has ever been in public service. Why should they start now?'

Rosie O'Donnell reignited her long-running feud with President Donald Trump during an appearance on Sirius XM radio on Wednesday. She is pictured with host Michelangelo Signorile

O'Donnell described the relationship between Ivanka and Donald Trump as 'creepy'

O'Donnell and President Trump have been locked in a bitter feud since late 2006, when the comedienne publicly questioned Trump's moral authority to judge Miss USA participants.

Speaking on The View at the time, O'Donnell described Trump as a 'snake-oil salesman' before she imitated his hairdo.

Trump responded in kind, calling O'Donnell 'fat' and 'a loser'.

In the intervening 13 years, he has repeatedly called O'Donnell a 'loser' - perhaps a reason why the comedienne has become an avid fan of women's soccer star, Megan Rapinoe, who also shares a distaste for the President.

In her interview on Wednesday, O'Donnell gushed over Rapinoe, 34, by describing her politics as 'on point'.

'She's so inspirational, and she's so well-spoken, and her politics are on point. I admire her greatly. She's so young to be so composed,' the Sleepless In Seattle star cooed.

She went on to describe the US soccer team's recent victory over The Netherlands as 'a thrill'.

'It made America remember what America is and can be,' she swooned.

Meanwhile, O'Donnell (left) gushed over US women's soccer captain Megan Rapinoe (right)

Never shy in sharing her opinion, O'Donnell didn't hold back during two separate interviews with Sirius XM on Wednesday

During another Sirius XM interview on Wednesday, O'Donnell spoke candidly about her contentious relationship with her former co-star on The View, Whoopi Goldberg.

Chatting on The Clay Cane Show, O'Donnell said she was left shocked by Goldberg's declaration that America was not a racist country.

Goldberg famously made the claim during a heated clash with O'Donnell on The View back in 2014.

'Whoopi saying there is no racism in this country, to me...I couldn't believe it... A black woman in America. Older than me. How's that possible? I don't know. I didn't understand it really, and I also didn't want to fight with a legend. One of the few black women who ascends to a level that very few black women ever get to,' O'Donnell remarked.

'She [Goldberg] was somebody I admired and I had tremendous respect for all of the activism that she has done in her life. [But] I was very surprised at what went down when she and I were on the show together.

O'Donnell explained: 'I was kind of shocked on a daily basis. It seemed though whatever I said, she wanted to say the opposite. It didn't matter what it was.

She went on to explain that she left The View after a short time, because she was left 'hurt' by Goldberg's attitude towards her.

'She really didn't like me, which is something that is very surprising and hurtful. I wasn't expecting that.'