Comcast Corp. on Friday terminated plans to acquire Time Warner Cable Inc., as increasing pressure from regulators prompted the end of the $45.2 billion deal.

“Today, we move on. Of course, we would have liked to bring our great products to new cities, but we structured this deal so that if the government didn’t agree, we could walk away,” Comcast Chief Executive Brian Roberts said in a news release Friday.

Time Warner Cable Chief Executive Robert D. Marcus said in a separate release that his company remains strong. “Throughout this process, we’ve been laser-focused on executing our operating plan and investing in our plant, products and people,” Mr. Marcus said.

Mr. Marcus added in an interview that Time Warner Cable could be a buyer or seller in any future deals and that the Comcast deal fell apart in the past couple days because of regulatory pushback.

“Suffice it to say that over the last couple of days it became clear that this deal was not going to be approved by the regulators,” Mr. Marcus said.