Seth MacFarlane could have a tough time defending his current Emmy title for Best Character Voice-Over Performance this weekend. His win last year at the Creative Arts Awards gave him a third career Emmy after winning the category in 2000 and picking up one for Best Music and Lyrics for “You’ve Got a Lot to See” from the show in 2002. In looking to collect his fourth trophy, MacFarlane is going to have to fend off challenges from an Oscar winner, another Emmy winner and three other contenders. Below, let’s take a look at each nominated performer and the episode they are recognized for.

MacFarlane is back with his 20th career nomination and is nominated for the “Family Guy” episode, “The Boys in the Band.” He’s cited for his work as Peter, Brian, Stewie and Glenn Quagmire even though he also appears in the episode as Carter Pewterschmidt. In the episode, Stewie complains that most songs for babies don’t speak to authentic baby experiences, so he forms a band with Brian to remedy this but it gets hijacked by Stewie’s ex-girlfriend, Olivia. In the show’s other storyline, Peter helps his son, Chris, land a job as Quagmire’s personal assistant. As with most episodes of “Family Guy,” MacFarlane gets to his show off his range with all the characters he plays and they’re all solid performances. He could find himself easily winning again but several other competitors stand in his way.

Oscar-winner Kevin Kline (Best Supporting Actor, “A Fish Called Wanda,” 1988) is looking to win his first career Emmy for “Bob’s Burgers” after getting nominated for Best Movie/Mini Actor in 2009 for “Cyrano de Bergerac.” Since the show’s first season, Kline has voiced the part of Calvin Fischoeder, the eccentric landlord of the Belcher family restaurant. He’s nominated for the episode, “The Last Gingerbread House on the Left.” Mr. Fischoeder invites Bob to his home to participate as a ringer in his annual gingerbread house competition so that he doesn’t lose, like he does every year. When Mr. Fischoeder’s insults go over the line, Bob decides to go all in and actually try to win the competition. Kline’s vocal talents are put to perfect use with Mr. Fischoeder and this episode has great material for him to play with. As the most famous name in this category, he could find himself winning like Anne Hathaway did for “The Simpsons” in 2010. The main difference would be this win being much more justified.

Nancy Cartwright makes her first appearance in this category after voicing Bart Simpson for 30 years on both “The Simpsons” and “The Tracy Ullman Show.” While this is her first competitive nomination, she did receive a trophy for her voice work in 1992, when the award was a juried one, along with several other “Simpsons” cast members. This year she is up for the episode “Looking for Mr. Goodbart.” When Bart gets in trouble on Grandparents’ Day at Springfield Elementary, he is forced to be a companion for Principal Skinner’s mother, Agnes. Bart ends up liking the attention and starts becoming a pretend grandson to several other elderly women and becoming particularly close to a woman named Phoebe. The storyline is sweet but there’s not much that makes Cartwright’s stand out from some of the other nominees.

Even though “BoJack Horseman” was criminally snubbed in the Animated Program category, the show managed to earn a nomination for Kristen Schaal who voices former child star Sarah Lynn on the Netflix series. She’s nominated for the penultimate episode from season three, “That’s Too Much, Man!” BoJack decides to go on a massive bender after finding out he wasn’t nominated for an Oscar and invites Sarah Lynn to join him. She accepts and in doing so breaks her nine-month sobriety. She tags along as BoJack crashes an AA meeting and stalks a young girl he almost slept with as they continuously stay drunk and high for several weeks. As they crash on the bed of a cheap motel, Sarah Lynn learns that she’s won an Oscar. She starts celebrating but very quickly realizes that she is incredibly unhappy with who she has become in life. BoJack tries to cheer her up by taking her to the planetarium and as they watch the show, she falls asleep and dies of an overdose. Schaal delivers a devastating performance as Sarah Lynn and has, without a doubt, the most emotional performance of all the nominees. Getting nominated was a big hurdle to clear and now that she’s in, she could very well pull off the win.

Another Netflix show, “F is for Family,” earns its first nomination for Mo Collins. She plays several characters including Ginny, Jimmy Fitzsimmons, Lex, Ben and Cutie Pie and is nominated for the episode “Pray Away,” which follows several storylines. The main characters, Frank and Sue, are at a church-led marriage counseling retreat along with Ginny, who is in complete denial that her husband is gay. Bill is nervous about being beaten up by Jimmy Fitzsimmons and devises a plan with his friends, including Ben, to preempt Jimmy. Kevin comes clean about an affair he had with Cutie Pie at a party with her boyfriend, Vic. The “Mad TV” alum does get to show a significant range but her characters are never the focus of the storylines and that could hurt her.

Rounding out the category is voice-over veteran Dee Bradley Baker, who is nominated for playing Klaus, an East German ski-jumper whose brain was transferred into the body of a goldfish. In his episode, “Fight and Flight,” Klaus orders a fancy pair of shoes online but believes that it was mistakenly delivered to a neighbor who has kept it. With Haley’s help, Klaus goes over to confront the neighbor and ends up taking him hostage. They search his house and even find another person bound and gagged in the man’s closet. Haley gets a phone call that their package was in the bushes of their house the whole time and Klaus reflects on the monsters they’ve become, without mentioning the other trapped person they just saw. It’s a hilarious performance from Baker, who, even with over 450 credits to his name, has never been nominated for an Emmy. If enough voters know how overdue he is, it could give him a serious shot at winning.

Be sure to make your Creative Arts Emmy predictions so that Hollywood insiders can see how their TV shows and performers are faring in our Emmy odds. You can keep changing your predictions until just before winners are announced on September 9 and 10. Don’t forget to make or change your predictions for the Primetime Emmys by September 17. And join in the fierce debate over the 2017 Emmys taking place right now with Hollywood insiders in our TV forums. Read more Gold Derby entertainment news.