Important Update - On Mar 20 2018, VMware VMSA-2018-0004.3 announced that CVE-2017-5715 (Spectre-2) mitigation is now included in the latest patch that you should be using instead of the older patch featured in the original article below . You'll find the newer article here:

Article below as it originally appeared.

VMware vCenter Server 6.5.0e Release Notes

vCenter Server Appliance 6.5.0e | 15 JUNE 2017 | ISO Build 5705665

See also:

Full Patch for VMware vCenter Server Appliance 6.5.0e (2150416)

kb.vmware.com/kb/2150416 Product Patch for vCenter Server Appliance 6.5 containing VMware software fixes, security fixes, and Third Party Product fixes. This patch is applicable for vCenter Server and Platform Services Controller Appliances.

Warning:

vCenter/VCSA 6.5 should be upgraded to 6.5.0e (aka 6.5 e) before upgrading your host(s) to ESXi 6.5.0d. There is currently no ESXi 6.5.0e version.

There's benefits to 6.5.0e, especially if you're coming from any version prior to 6.5.0d, since this VCSA version, coupled with ESXi 6.5.0d, will enable you to enable the new and greatly improved vSAN 6.6! See also:

Yep, upgrading via VAMI works as advertised, just like it did when going from 6.5 to 6.5.0a back in February, and to 6.5.0b in March, and to 6.5.0c and 6.5.0d in April, and finally to 6.5.0e in June. This is a very easy upgrade, as shown screen-by-screen walk through below, and in the video below.

VCSA 6.5.x with Internet access/DNS configured

If your VCSA has no internet access, consider downloading this offline update bundle instead:

If your VCSA has no internet access, consider downloading this offline update bundle instead: VMware vCenter Server Appliance Update Bundle

Warning:

You need to do your homework before upgrading, if you're wondering why, read this. Do this VCSA 6.5.0e upgrade in a test environment first! Before attempting, you should be sure to have a full backup, such as the simple native VCSA backup button seen at top-right. You can also use a 3rd party backup solution such as NAKIVO or Veeam. At a minimum, do a snapshot (or backup) of this VCSA VM before upgrading, then make sure everything works alright after the upgrade, then remove the snapshot within a few days, to avoid performance degradation.

If you're looking for how you get from 6.0.x to 6.5, that's more of a migration, and the right article for you is over here:

How to easily update your VMware vCenter Server Appliance to VCSA 6.5

Nov 20 2016

It looks like you have JavaScript disabled. Click here to view the video above. VCSA upgrade to 6.5.0b using VAMI. Upgrading to 6.5.0e Build 5705665 is essentially the same.

How to easily update your VCSA 6.5 to 6.5.0d Build 5318154 and ESXi to Build 5310538. Upgrading to 6.5.0e Build 5705665 is essentially the same.

Takes about 2 to 3 minutes to upgrade, if your VCSA VM is located on an SSD based datastore, such as the Samsung 960 EVO 1TB M.2 NVMe SSD I used for my home datacenter, featured in this video.

in your browser, go to your VCSA IP or Name:5480

login with root and your password

along the left edge of DCUI, click 'Update', then click on 'Check Updates', then on 'Install Updates' and 'Install All Updates'

click on 'I accept' checkbox, then click on 'Install'

wait for a bit, on SSDs, a bit is less than 2 minutes

wow, you're done already

at left, click on 'Summary', then at right, click on 'Reboot'

login with root and your password

along the left edge of DCUI, click 'Update', optionally also clicking on 'Check Updates' then 'Check Repository', with the DCUI showing you confirmation that you're already done, since you're at 6.5.0.5500 Build Number 5705665