BOSTON (AP) -- Jon Lester has survived cancer and pitched a World Series clincher for the Boston Red Sox.

Now he can add a no-hitter to his already amazing list of accomplishments.

The 24-year-old lefty shut down Kansas City 7-0 Monday night for the first no-hitter in the majors since Red Sox rookie Clay Buchholz threw one last September.

It was Lester's first major league complete game. And what a way to do it.

"You don't feel tired in that situation. You've got so much adrenaline going," he said. "I'm sure it will hit me in the morning."

Lester (3-2) allowed just two baserunners, walking Billy Butler in the second inning and Esteban German to open the ninth; he also had an error when he threw away a pickoff attempt.

Lester struck out nine, fanning Alberto Callaspo to end the game before pumping both fists in the air.

Catcher Jason Varitek, who has been behind the plate for a record four no-hitters, lifted his pitcher into the air. Manager Terry Francona gave a long, hard embrace to Lester, who missed the end of the 2006 season after he was diagnosed with a rare form of non-Hodgkin's lymphoma.

"I've been through a lot the last couple of years. He's been like a second dad to me," Lester said. "It was just a special moment right there."

Center fielder Jacoby Ellsbury made a diving catch of Jose Guillen's line drive to end the fourth -- the best defensive play of the night. Lester also got help from first baseman Kevin Youkilis, who made a nice scoop on shortstop Julio Lugo's throw after David DeJesus hit a grounder in the third.

The fans at sold-out Fenway Park held their enthusiasm until the final out of the seventh, rising to their feet when Lester fanned Guillen on a 93 mph fastball. They remained standing for the entire ninth inning, even as German walked and moved around to third base when Tony Pena and DeJesus grounded out.

With cameras flashing and the fans screaming at full throat, Callaspo fell behind 0-2. He took a ball and fouled one off before reaching for a high and outside 1-2 fastball to end the game.

"I was trying to do what I could do," Callaspo said. "You had to ... try to get the bat on the ball."

Lester and Varitek were mobbed by teammates running out of the dugout as the speakers played "Tessie," the victory anthem the Red Sox adopted through two World Series titles in four seasons. Lester was instrumental in the second, less than a year after chemotherapy cured his cancer, when he earned the victory in Game 4 at Colorado to complete the Red Sox sweep.