It's been far too long since we've gotten to see the work of Cary Fukunaga. After the release of his 2015 Netflix film Beasts of No Nation—the movie that announced the streaming service as a serious awards-season player—and following his departure from 2017's It, the director has been relatively quiet. That changes this fall with Maniac, a ten-episode limited series starring Jonah Hill and Emma Stone. And based on its first trailer, it looks like nothing he's done before.

The teaser features Stone and Hill facing each other in a sterile room in clinical garb, as a voiceover briefly muses about how "the mind can be solved."

While this extremely bare-bones tease might be a bit frustrating, it's kind of cool to see Fukunaga—a director who won the world over with muted, beautiful camerawork across wide, sinister spaces in films like Sin Nombre and, of course, True Detective—make a hard pivot away from what he's known for. (Which, of course, could still be present in Maniac.) The premise of the show is a little less mysterious than this teaser would lead you to believe, as it's an adaptation of a 2014 Norwegian series of the same name, and Netflix provided the press with a summary during this week's Television Critics Association press tour:

Set in a world somewhat like our own and similar to our time, Maniac tells the stories of Annie Landsberg (Stone) and Owen Milgrim (Hill), two strangers drawn to the late stages of a mysterious pharmaceutical trial, each for their own reasons. Annie’s disaffected and aimless, fixated on broken relationships with her mother and her sister; Owen, the fifth son of wealthy New York industrialists, has struggled his whole life with a disputed diagnosis of schizophrenia. Neither of their lives have turned out quite right, and the promise of a new, radical kind of pharmaceutical treatment—a sequence of pills its inventor, Dr. James K. Mantleray (Justin Theroux), claims can repair anything about the mind, be it mental illness or heartbreak—draws them and ten other strangers to the facilities of Neberdine Pharmaceutical and Biotech for a three-day drug trial that will, they’re assured, with no complications or side-effects whatsoever, solve all of their problems, permanently. Things do not go as planned.

Maniac will premiere September 21.