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PORT Adelaide defender Cam O'Shea is on the lookout for a new club after six seasons and 81 games with the Power.

He becomes the seventh Port player to depart the club in the wake of a second successive season without finals.

O'Shea posted a message on Instagram on Sunday morning confirming his time with the Power had come to an end.

"Thanks for the good times @pafc loved the highs and lows of the past 6 years. Looking forward to what's next," O'Shea wrote.

O'Shea joined the Power with the 52nd pick of the 2010 NAB AFL Draft.

His most productive season was in 2013 when he played all 24 games, including the club's two finals appearances.

O'Shea has played only 35 games for the Power in the past three seasons, including 13 this year.

Rival clubs can now secure O'Shea as a delisted free agent from November 1.

Standing 193cm, O'Shea, recruited from Victoria's Eastern Ranges, has the height to play a variety of roles in defence. He also possesses the running capacity to have bursts through the midfield

Along with O'Shea's departure, defender Alipate Carlile has retired, while Jay Schulz, Paul Stewart, John Butcher and rookies Kane Mitchell and Sam Colquhoun have been delisted.

"We have now finalised our delistings ahead of tomorrow's first list lodgement deadline," Power football manager Chris Davies told portadelaidefc.com.au.

"We thank Cam for his service over the last six seasons and wish him the very best with his future in footy. These decisions are always very difficult but we make them with a long-term view to our list management.

"That marks seven changes to our list ahead of the draft, and with four picks inside the first 31, we're happy with our position heading into pre-season."

Angus Monfries, Nathan Krakouer and Tom Jonas have all signed new deals with the club.

The Power is keen to reinvigorate its list and add more youth to its experienced core.

The Power switched draft picks with the Sydney Swans on the final day of the NAB AFL Trade Period to secure four picks inside the top 31.

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That was after the Power unsuccessfully tried to shop several veteran players to other clubs, including midfielder Hamish Hartlett and ruck Matthew Lobbe, who have long-term contracts.