Johnny Clegg, a British-born South African singer, songwriter and guitarist whose fusion of Western and African influences found an international audience and stood as an emblem of resistance to the apartheid authorities in his adopted land, died on Tuesday in Johannesburg. He was 66.

His manager, Roddy Quin, announced the death. Mr. Clegg learned in 2015 that he had pancreatic cancer.

From his teenage years onward, Mr. Clegg ventured with ever greater boldness across racial lines. He spent time in the gritty, violence-prone hostels reserved for migrant black mineworkers that were formally off limits to most of his fellow white South Africans. His music crossed racial lines as well.

In the bands Juluka (“Sweat” in the isiZulu language) and Savuka (“We have risen”) and as a solo artist, Mr. Clegg became known for songs and performances that resonated through South Africa’s long struggle against racial separation.