Drug taskforce detectives have uncovered thousands of ecstasy pills, methamphetamine and cash during separate raids on two Melbourne dance clubs that led to serious trafficking charges against an owner and other staff.

The discovery of large quantities of drugs at Two Floors Up nightclub in the CBD and Brunswick's Railway Hotel has raised serious concerns about the licensing and regulation of Melbourne's late-night venues.

Promotion for the "Jail House Rock" event at night club Two Floors Up, featuring Jason Kolbeck (pictured). Credit:Facebook

Both clubs have been allowed to continue trading, despite the three men charged with serious trafficking offences being involved in the management and operation of the clubs.

On April 15, the drug taskforce raided the The Railway Hotel on Albert Street, along with three other properties in Brunswick and Elwood.