A father accused of murdering his wife was taking medication for schizophrenia, a Melbourne court has heard.

Alberto Ganad was taken into custody last night as the Homicide Squad arrived at his Sunnybrae Circuit home at around 7:20pm.

Neighbours have told 9NEWS paramedics were first on scene, but couldn't revive a 59-year-old woman found dead inside.

Paramedics were first on scene, but couldn't revive a 59-year-old woman found dead inside. (Supplied) (Nine)

Mr Ganad faced the Melbourne Magistrates' Court this morning. (9NEWS) (9news)

The exact nature of her injuries is yet to be revealed.

One of the couple's sons was seen crying on the footpath as forensic detectives secured his home.

Neighbour and friend, Jayden Stojanovski was shocked that a murder could happen in such a "normal" family.

Neighbours have described the father as 'quiet'. (Supplied) (Nine)

"The dad, I never really heard him speak. He seemed like a quiet guy,” he said.

"It's sad you know because the family’s broken and his Dad, they’re probably not going to recognise him as a dad anymore."

Law student, Filip Momiroski grew up with the couple’s son and says he's "in shock."

"Both of the parents were very welcoming," he told media outside.

"During the holidays they would come out and greet everyone in the street. They did ballroom dancing. They used to be like a normal family that had normal events, but it seems like now that was just a front and there was a lot more to it that the others didn't know."

The exact nature of her injuries is yet to be revealed. (9NEWS) (Nine)

Alberto Ganad (left) was taken into custody last night shortly after the homicide squad arrived at his Sunnybrae Circuit home. (Supplied) (Nine)

Facing the Melbourne Magistrates Court this morning, Mr Ganad arrived in the dock wearing a baggy, green t-shirt.

The 59-year-old didn't speak, but nodded and grunted in acknowledgment as an interpreter talked him through the filing hearing.

Police allege audio from nearby CCTV picked up an argument between the couple before emergency services were called.

Magistrate Charlie Rozencwaijg told Mr Ganad's defence lawyer "it doesn't appear the facts in this matter are going to be an issue."

Police were called to the property just before 7.30pm yesterday. (9NEWS) (Nine)

Authorities have not yet revealed how the woman was killed. (9NEWS) (Nine)

"The real issue is going to be the mental state of the accused... you have to decide which way you plea."

Mr Ganad will reappear via video link when the case returns to the Magistrate's court for a committal mention on June 20.