USA Network has cast the four leads in the Denis Leary comedy pilot Sirens: Michael Mosley (Pan Am, Scrubs), Kevin Daniels (Modern Family), Kevin Bigley and Jessica McNamee. Co-created by Leary and Bob Fisher, Sirens follows three of Chicago’s best EMTs — Johnny (Mosley), Hank (Daniels) and Brian (Bigley) — whose sometimes self-loathing, other times narcissistic, and always downright self-destructive personalities make them unqualified for sustaining relationships, friendships and most occupations. They are, however, uniquely qualified for saving anyone unlucky enough to wind up in their ambulance. Johnny is a good-looking, sports-loving, Chicago EMT working with his best friend Hank. Brian is a wide-eyed and excitable new EMT who still lives with his parents. McNamee will play the female lead, Theresa, a smart female cop with the Chicago PD who still loves her ex Johnny, but ultimately had to move on when he wouldn’t commit. The pilot, produced by Fox TV Studios, will shoot in Chicago later this month.

Sirens is one of two single-camera comedy pilots USA ordered this summer, along with Paging Dr. Freed, which recently wrapped production, as the network is looking to launch an original half-hour comedy in time for the fall 2013 off-network syndication premiere of Modern Family. Mosley is with Gersh and Smith Talent Management. Daniels is with Stone Manners Salners.