The partner of a 34-year-woman who died in a head-on collision in Palmerston overnight says he does not know how to tell her six-year-old daughter her mum is not coming home.

Key points: The drivers of the two cars died at the scene

The drivers of the two cars died at the scene A passenger in the man's car was taken to Royal Darwin Hospital

A passenger in the man's car was taken to Royal Darwin Hospital The NT road toll for 2020 now stands at five

Wei-kai Lee said his partner Evelin Kwok was a nurse in a nursing home and was "very compassionate about her work and clients".

"Evelin is a mum of two girls, one is turning to six in April and is one turning to two next month," Mr Lee said.

"Even though she worked the overnight shift, she still spent time with the girls before they went to bed as well as on her day off.

"She saw Australia [as] her home as she has spent 10 years here and she believed it's the best place for her daughters to grow up.

"I don't know how to tell the older girl about what happened to mum."

Evelin Kwok was a nurse in a nursing home and was "very compassionate about her work and clients". ( Supplied: Facebook )

Two fatalities in horror crash

NT Police Watch Commander Ron Miller said officers came across the scene on Roystonea Avenue late Friday night.

"At about 11 o'clock last night one of our police patrols came across a two-car collision, there were already witnesses at the scene assisting," said Watch Commander Ron Miller.

The drivers of both two cars — Ms Kwok and a 20-year-old man — died at the scene.

A 21-year-old male was also taken to Royal Darwin Hospital (RDH) with serious injuries.

"The 34-year-old female driver … was deceased at the scene upon arrival," Watch Commander Miller said.

"And the driver [of the other car] also then died of his injuries."

Police said it was too early to say if there were any contributing factors to the incident. ( ABC News: Felicity James )

Car in flames, two trapped

Police allege the Toyota Corolla driven by the 20-year-old man was going down the wrong side of the road on Roystonea Avenue and crashed head-on with the woman's Hyundai Sedan.

Witnesses of the crash were able to remove a 21-year-old male passenger from the 20-year-old man's car, prior to the arrival of police.

The 20-year-old man was trapped inside the Toyota Corolla with the vehicle still on fire, NT Police said in a statement.

A 20-year-old man was trapped inside the car with the vehicle on fire. ( ABC News: Felicity James )

"Police at the scene managed to extinguish the fire, and Fire and Rescue members extracted the driver, who died at the scene," the statement read.

Watch Commander Miller said the 21-year-old man was taken to hospital with serious injuries but was in a stable condition.

"Roystonea Avenue is closed near Lambrick Avenue for the crash investigation to occur, and it'll be closed for a number of hours this morning."

Police said it was too early to say if there were any contributing factors to the incident and the Major Crash Investigation Unit was looking into the crash.

St John Ambulance NT operations manager Craig Garraway said the 21-year-old was taken to RDH with "non-life-threatening injuries".

A Royal Darwin Hospital spokeswoman said the man was in a stable condition.

Mr Lee said a few months ago, Ms Kwok got the sponsorship from the NT Government for a 489 visa for the family.

"She was so excited about it," he said.

"However, she hasn't got it before she passed away. "

The NT road toll for 2020 now stands at five.