As previously reported by BoxingScene.com, WBC heavyweight champion Deontay Wilder set his sights on Anthony Joshua after defending his world title with a brutal first-round knockout of Dominic Breazeale in New York on Saturday night.

Wilder sent Breazeale crashing to the canvas with a steamroller right hand just two minutes and 17 seconds into the opener at the Barclays Center.

The devastating knockout extended the 33-year-old’s unbeaten record to 41 wins and a draw from 42 bouts.

Wilder, who drew with Tyson Fury in his last fight in December, and unbeaten WBO, WBA, IBO and IBF champion Joshua have struggled to agree terms on a bout in the past.

Despite two knockdowns, many felt Fury had outboxed Wilder only for the fight to end in a controversial draw.

Despite that outcome, the biggest fight to make in boxing is a showdown between Wilder and Joshua.

Hall of Famer and former heavyweight world champion, George Foreman, believes a unification between Wilder and Joshua would be the biggest fight in heavyweight history.

"He hit [Breazeale] so hard, like we did back in the day. He hit him so hard that I ran and went under my bed. My wife asked me 'where are you going' and I said 'I don't want him to come after me.' That's a puncher, a real live puncher," Foreman told TMZ

"It's hard to say [if Wilder is the biggest puncher] of all-time. Joe Louis was the biggest knuckle-cruncher there is. Wilder is developing that kind of power. He's hitting a lot harder than I did with the right hand - that's for certain.

"In my day, with that right hand that he throws - I've never seen that before. That right hand is powerful, and he could have probably knocked out anyone at any time in the heavyweight division - it don't matter if it was George Foreman, Mike Tyson Joe Frazier, anyone could have gotten it from him.

"If Joshua and Wilder fight - it would be the biggest heavyweight fight of all-time, bigger than anything, if they actually fought."