Donald Trump opened his most commanding national lead yet, with nearly 50 percent support of Republicans — more than the next four candidates combined, a poll revealed on Monday.

Trump had 49 percent, compared to Marco Rubio at 16 percent, Ted Cruz with 15 percent, Ben Carson at 10 percent and John Kasich with 6 percent, CNN pollsters reported.

The 33-point gap between Trump and his next closest opponent is the biggest lead reported yet in any poll taken this cycle.

CNN’s survey was taken between Wednesday and Saturday, so after his big wins the South Carolina primary and Nevada caucuses – but before this past weekend when he failed to clearly denounce an endorsement by former KKK leader David Duke.

On the Democratic side, Hillary Clinton held a 55-38 lead on Bernie Sanders.

The poll was based on 1,001 interviews — 600 by landline phones and 301 on cell phones. The margin of error was +/- 3 points.