A cannabis and amphetamine drug ring has been busted in Logan, south of Brisbane, stopping more than $850,000 worth of drugs hitting the streets, according to Queensland Police.

Officers searched 19 homes and businesses in Logan, Brisbane and in north Queensland after a long-term investigation.

Logan District Detective Inspector Christopher Jory said it was a highly-sophisticated drug network, describing the bust as one of the biggest in Logan's history.

"I am confident it will have an impact on overall crime in the Logan district," he said.

So far, 27 people have been arrested on 55 charges.

Police will allege they were trafficking drugs in and around the Logan area as well as other parts of the state.

About 35 kilograms of cannabis worth $840,000 was seized along with nearly a kilogram of amphetamines, which has a street value of about $15,000, police said.

About $110,000 in cash was also uncovered.