Ten Network's long-running love affair with The Simpsons has finally drawn to a close after Fox issued a letter of termination for its programs on the Aussie network.

In a statement made to the market late yesterday, Ten's administrators KordaMentha alerted shareholders it had received the letter from Twentieth Century Fox Film Corporation, which states no Fox programs will air as of October 6, 2017.

The deal between Fox and Ten was estimated to be worth $376.8 million, and was originally set to run until late June 2019.

But after news broke that CBS – a direct American rival of Fox – had bought the Australian network, it had decided to pull its slate of extremely popular programs from Ten.

Among the programs expected to be pulled include M*A*S*H, Modern Family, Malcolm in the Middle and Futurama.

(Related video: What will happen to Ten's hit shows?)

The final stage in CBS' takeover of Ten will occur today in the NSW Supreme Court in Sydney, a week after the Foreign Investment Review Board approved the sale.

The $41 million CBS takeover bid trumped a competing offer from billionaire Ten shareholders Lachlan Murdoch and Bruce Gordon and was almost unanimously backed by Ten's creditors, including the broadcaster's employees, at a meeting in September.

The network slipped into administration after the pair, along with fellow shareholder James Packer, refused to back a new finance package following the expiry of a $200 million debt facility.

KPMG in October evaluated Ten's business to examine whether shareholders were disadvantaged by the CBS deal, in which the US broadcaster will pay nothing for Ten's shares.

The auditor described the company's shares as worthless, with the value of Ten's business operations outweighed by debts on its outstanding content contracts with CBS and Twentieth Century Fox.

It said Ten's business would need to have a net value of $646.9 million in order for its shares to have any value, well above the $112 million it was worth under the best-case scenario KPMG applied to its analysis.

If approved by the NSW Supreme Court, the transfer of Ten's shares to CBS will leave shareholders with nothing.

With AAP.