A prominent Brisbane restaurant owner, whose brother was bludgeoned to death, has been arrested on drug charges.

Police executed 11 search warrants on Friday morning in what has been described as one of the biggest cocaine operations in the history of Queensland police.

One of the premises raided was Toowong Italian restaurant Mariosarti, with owner Daniel Milos arrested. Police also raided 10 other addresses across the Gold Coast and Brisbane, including a Fig Tree Pocket home.

Police said five people in total had been arrested on 33 drug-related charges and expected further charges to be laid at a later date. The others in custody have been described as Mr Milos' "business associates".