Dr. Teruko Ishizaka, an immunologist whose joint research with her husband in the 1960s advanced the monitoring, treatment and prevention of asthma, hay fever and drug and food allergies, died on June 4 in Yamagata, Japan. She was 92.

Her death was announced by the La Jolla Institute for Immunology in San Diego, where she had been head of the allergy division. Her husband, Dr. Kimishige Ishizaka, had been the institute’s scientific director and president. He died last July, also at 92. They had retired to their native Japan in 1996.

Together they discovered a novel class of antibodies that trigger wheezing, itching, rashes and various allergic reactions.