The Rams’ playoff chances are on life support after getting blown out by the Cowboys, needing to win out and get help in the final two weeks of the season. Up next is San Francisco, which beat the Rams 20-7 in Week 6, limiting Jared Goff to only 78 yards passing.

Sean McVay has never lost to the same team twice in a season, and he’ll try to avoid that happening this weekend. The Rams have the talent to beat the 49ers, who were just upset by the Falcons, but they need to put it together and play well for 60 minutes.

Here are five key matchups to watch in this one.

Robert Woods vs. Richard Sherman

Sherman is expected to return after missing Sunday’s game against the Falcons, and that’s a big boost to the 49ers defense. He’s been excellent this season, playing like one of the best cornerbacks in the NFL. Woods has been the Rams’ top receiver in recent weeks and should get the bulk of the targets on Saturday night, but picking on Sherman is never a great idea.

Cooper Kupp hasn’t been much of an option recently and Brandin Cooks has done next to nothing since returning from his concussion, which leaves Woods as the primary weapon on offense.