Kyle Sandilands and Jackie O are leaving 2Day FM at the end of the year after more than a decade on air together, Southern Cross Australia has announced.

Contract negotiations between Australia's most successful FM radio duo have collapsed, with the pair not returning to the Austereo network in 2014, bringing to an end a decade of ratings dominance.

In a statement issued by the broadcaster on Friday morning, Southern Cross Austereo head of content Craig Bruce said: “We’re proud that Kyle and Jackie have not only given Sydney radio audiences the most entertaining radio show ever, they have also raised millions of dollars for charities and those in need whilst also enthralling listeners with the world’s hottest music artists and exclusive interviews with famous Hollywood celebrities.