Police are investigating an automatic teller machine explosion in West Perth that appears to have been timed to go off during the Skyworks show.

Firefighters and police were called to the Harbour Town shopping centre just before 8.30pm on Saturday night after reports of an explosion.

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Bomb squad and forensic officers are combing the scene with the help of Perth brigade firefighters.

Police believe no one was injured in the incident.

It is understood the explosion has caused considerable structural damage to the centre and it may not be open for Sunday trading.

Anyone with information about the crime is asked to call Crime Stoppers on 1800 333 000.