Queen Elizabeth II has had crisis talks with Prince Charles over Prince Andrew’s mushrooming Jeffrey Epstein scandal, according to a report Thursday.

Britain’s monarch and her eldest son took time out for emergency talks on “family matters” over Andrew this week — just two weeks after holding the royal family’s historic summit on Megxit, the Sun says.

The Duke of York, already booted from royal duties over his ties to Epstein, was back in the spotlight Monday after being accused of giving “zero cooperation” to the FBI as agents tried to quiz him as part of the ongoing investigation into the late pedophile’s inner circle.

In an added blow, Britain’s Metropolitan Police also revealed plans to possibly reopen its own investigation into Epstein. That is likely to center on accuser Virginia Roberts Giuffre’s claim in court filings that she was trafficked to London to have sex with the royal in 2001 when she was 17.

Renewed focus on Andrew’s ties is particularly troubling for the Queen, who had been leaning on Andrew as a “rock” during the crisis over Prince Harry and wife Meghan Markle quitting the royals.

She recently stood beside him at church — her most public display of support — and she and heir to the throne Charles both hoped Andrew “could perhaps be rehabilitated back into public life in time,” a royal source told the Sun.

“That is now looking increasingly unlikely,” the source conceded.

Andrew and Buckingham Palace have always vehemently denied the accusations against the duke. Epstein, 66, died in a Manhattan lockup Aug. 10 while awaiting trial on federal sex trafficking charges.

Buckingham Palace declined to comment to the Sun.