The LD50 (lethal dose) for pure Fentanyl, is estimated at 2 milligrams (mgs) for a typical adult [Reference: RCMP and United States Drug Enforcement Administration (DEA]. Since illicit drugs are typically diluted or cut with inert materials, exposure of first responders to pure forms of opioids are less likely. However, inconsistent mixing of illicit drugs may mean that high concentrations may still be encountered, and small amounts can still be dangerous. Any sample suspected of containing opioids requires adequate preparation, protection and care in handling.