Democrats are feeling bullish about their chances to win a Senate seat in Georgia in the wake of GOP Sen. Johnny Isakson Johnny IsaksonDemocrats ramp up pressure on Lieberman to drop out of Georgia Senate race Obama endorses Warnock in crowded Georgia Senate race Lobbying world MORE’s decision to retire.

The announcement, Democrats argue, gives them a golden opportunity to expand the Senate battleground map heading into 2020 and chip away at the GOP’s Senate firewall.

Nikema Williams, the chair of the Democratic Party of Georgia, immediately pledged that the state would be a must-watch “battleground” in 2020, saying after Isakson’s announcement that it “has never been clearer that the path for Democratic victory runs through Georgia.”

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Georgia has typically been a safe Republican state, but Democrats made gains in House races in 2018 when Rep. Lucy McBath Lucia (Lucy) Kay McBathThis week: House returns for pre-election sprint House Democrats' campaign arm reserves .6M in ads in competitive districts Black Lives Matter movement to play elevated role at convention MORE (D) defeated GOP Rep. Karen Handel Karen Christine HandelHouse Democrats' campaign arm reserves .6M in ads in competitive districts Black Lives Matter movement to play elevated role at convention QAnon backer Marjorie Taylor Greene wins Georgia GOP runoff MORE in the state’s 6th Congressional District. The party also came close to winning the governorship when Stacey Abrams lost in a close race to Republican Gov. Brian Kemp.

Other stars may also be aligning for Democrats in Georgia.

The party believes the state’s demographics are moving in its direction, and President Trump Donald John TrumpFederal prosecutor speaks out, says Barr 'has brought shame' on Justice Dept. Former Pence aide: White House staffers discussed Trump refusing to leave office Progressive group buys domain name of Trump's No. 1 Supreme Court pick MORE’s low approval ratings have Democrats thinking he may leave other Republicans vulnerable.

In 2016, Trump defeated Democratic presidential nominee Hillary Clinton Hillary Diane Rodham ClintonBloomberg rolls out M ad buy to boost Biden in Florida Hillicon Valley: Productivity, fatigue, cybersecurity emerge as top concerns amid pandemic | Facebook critics launch alternative oversight board | Google to temporarily bar election ads after polls close Trump pledges to make Juneteenth a federal holiday, designate KKK a terrorist group in pitch to Black voters MORE by 5 percentage points in Georgia, but only won a little more than 50 percent of the vote. That’s given Democrats new hope of winning the state in the presidential race.

Even if that dream doesn’t come true for the party, Democrats like their chances of winning the open Senate seat in a year when Trump will be at the top of the ticket and Georgia Republicans will also be defending GOP Sen. David Perdue’s seat.

J.B. Poersch — the president of the Senate Majority PAC, an outside group aligned with Senate Democrats — said the open Senate race “increases our chances of retaking the majority.”

“I expect Georgia and both seats to be competitive in 2020,” he added.

The Isakson retirement complicates life for Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellDemocratic senator to party: 'A little message discipline wouldn't kill us' House to vote on resolution affirming peaceful transition of power Republican lawyers brush off Trump's election comments MORE (R-Ky.), who is doing everything in his power to keep the Senate majority in GOP hands.

Democrats need to pick up three or four seats, depending on which party controls the White House, to win back the Senate majority.

Though Republicans are defending 22 seats compared to Democrats' 12, most are viewed as safe bets for reelection. That leaves the Senate battleground map limited to a handful of states including Arizona, Colorado, Maine and North Carolina, where GOP Sens. Martha McSally Martha Elizabeth McSallyOn The Trail: Making sense of this week's polling tsunami The Hill's Campaign Report: Presidential polls tighten weeks out from Election Day Mark Kelly: Arizona Senate race winner should be sworn in 'promptly' MORE, Cory Gardner Cory Scott GardnerBreaking the Chinese space addiction Trump dumbfounds GOP with latest unforced error Billionaire who donated to Trump in 2016 donates to Biden MORE, Susan Collins Susan Margaret CollinsDemocratic senator to party: 'A little message discipline wouldn't kill us' Poll: 57 percent of Americans think next president, Senate should fill Ginsburg vacancy On The Trail: Making sense of this week's polling tsunami MORE and Thom Tillis Thomas (Thom) Roland TillisOvernight Energy: Trump officials finalize plan to open up protected areas of Tongass to logging | Feds say offshore testing for oil can proceed despite drilling moratorium | Dems question EPA's postponement of inequality training On The Trail: Making sense of this week's polling tsunami Feds say offshore testing for oil can proceed despite drilling moratorium MORE, respectively, are on the ballot. Republicans view Alabama, where Sen. Doug Jones (D) is running for reelection in a deep-red state, as their best chance for a pick-up.

Isakson’s retirement will set the stage for a special election that will be a “jungle primary,” and a likely run-off election if no one gets 50 percent next year, for the final two years of his term.

“I think what you really see is the floor rising for Democratic candidates ... and it just becoming increasingly competitive,” said a national Democratic strategist watching the Senate races. “It’s going to be a battleground next year.”

The strategist added that Georgia “is a fundamentally competitive state. It adds another path to the majority.”

If Democrats are able to pick up Isakson’s seat, or knock off Perdue, it would be the first time the state has sent a Democrat to the Senate since 2000, when Zell Miller was elected to finish out the term of Sen. Paul Coverdell (R), who died while in office.

Kyle Kondik, managing editor of Sabato’s Crystal Ball at the University of Virginia, said Democrats have been looking for ways to expand the Senate map and Isakson’s decision “puts another potentially vulnerable Republican seat on the board.”

Still, he said it won’t be easy.

“I think I would still rather be the Republican in that state,” Kondik said.

He said that historically the two Georgia seats are likely to swing in the same direction, meaning if Perdue wins, the GOP nominee to succeed Isakson would also likely win. The last time a state had both of its Senate seats up in the same election and the results split was 1966 in South Carolina.

Isakson is the fourth Republican senator to announce in recent months that he would retire. Sens. Pat Roberts Charles (Pat) Patrick RobertsThe Hill's Morning Report - Sponsored by Facebook - Washington on edge amid SCOTUS vacancy The Hill's Morning Report - Sponsored by National Industries for the Blind - Trump seeks to flip 'Rage' narrative; Dems block COVID-19 bill GOP senators say coronavirus deal dead until after election MORE (Kan.), Lamar Alexander Andrew (Lamar) Lamar AlexanderPelosi urges early voting to counter GOP's high court gambit: 'There has to be a price to pay' Graham: GOP has votes to confirm Trump's Supreme Court nominee before the election The Hill's Morning Report - Sponsored by Facebook - Washington on edge amid SCOTUS vacancy MORE (Tenn.) and Mike Enzi Michael (Mike) Bradley EnziChamber of Commerce endorses McSally for reelection Cynthia Lummis wins GOP Senate primary in Wyoming The Hill's Convention Report: Democrats gear up for Day Two of convention MORE (Wyo.), who were each up for reelection in 2020, are also stepping down.

“This is yet another seat Republicans will need to defend next year in an increasingly competitive battleground where the president's approval has plunged by double digits since taking office,” said Stewart Boss, a spokesman for the Democratic Senatorial Campaign Committee.

It’s unclear who will be the GOP nominee. Under state law, Kemp will be able to appoint someone to temporarily fill the seat once Isakson steps down at the end of the year.

Several Republican names are already being floated, including Rep. Doug Collins Douglas (Doug) Allen CollinsDemocrats ramp up pressure on Lieberman to drop out of Georgia Senate race The Hill's Campaign Report: Biden on Trump: 'He'll leave' l GOP laywers brush off Trump's election remarks l Obama's endorsements GOP, Democrats look to galvanize women with SCOTUS fight MORE, Rep. Tom Graves John (Tom) Thomas GravesRep. Tom Graves announces early retirement Democrat in race against Marjorie Taylor Greene drops out McEnany: Trump 'hasn't done deep dive' on anti-Muslim views of Loomer, Greene MORE, Lt. Gov. Geoff Duncan, state Attorney General Chris Carr and Agriculture Secretary Sonny Perdue George (Sonny) Ervin PerdueTrump administration finalizes plan to open up protected areas of Tongass National Forest to logging Perdue has found the right path in National Forests Democrats seek clarity on payroll tax deferral for federal workers MORE, a former governor of Georgia and David Perdue's first cousin.

“I’m not going to tell you this was a positive development by any stretch,” one GOP strategist said. “[But] I think Republicans start favorites to hold onto the seat.”

Republicans did catch a significant break on Wednesday when Abrams quickly announced that she would not jump into the race for Isakson’s seat. Democrats had also tried unsuccessfully to get Abrams, viewed as a rising star in the party, to run against Perdue.

“Without her in it, you know even some of the names that are being tossed around are not on her level,” the GOP strategist said.

A second GOP operative was more bullish, predicting that Democrats wouldn’t be able to field a strong challenger to make a play for Isakson’s seat. Asked if there was a Democrat besides Abrams that they were worried about, the operative quipped: “None.”

But Democrats view the state as competitive even if Abrams isn’t in the race, arguing her campaign in 2018 showed that the party can compete in the Southern state. Several names of potential candidates that are being publicly floated include McBath, former gubernatorial candidate Jason Carter, former Senate candidate Michelle Nunn, DeKalb County CEO Michael Thurmond and former congressional candidate Jon Ossoff.

“[It’s] fundamentally competitive without Abrams,” the Democratic strategist said, asked about comments from Republicans that the party lacks a bench of strong candidate to compete for the Senate seat.

National Democrats are also keeping a close eye on the field and laying down early goal posts.

Aimee Allison, founder of She the People, said following Isakson’s retirement announcement that Georgia was primed to “elect at least one Democratic Senator.”

“Women of color remain the Democratic party’s most loyal voters and are changing what is possible in politics. Abrams revolutionized Georgia’s political landscape,” she added. “To be successful in Georgia, Democrats need to support a candidate who captures the spirit of Abrams’ progressive campaign.”