Even with the human genome in hand, geneticists are split about how to deal with issues of race, genetics and medicine.

Some favor using genetic markers to sort humans into groups based on ancestral origin – groups that may show meaningful health differences. Others argue that genetic variations across the human species are too gradual to support such divisions and that any categorisation based on genetic differences is arbitrary.

These issues have been discussed in depth by a multidisciplinary group – ranging from geneticists and psychologists to historians and philosophers – led by Sandra Soo-Jin Lee of Stanford University, California.

Now the group has released a set of 10 guiding principles for the scientific community, published as an open letter in this week’s Genome Biology.


1. All races are created equal

No genetic data has ever shown that one group of people is inherently superior to another. Equality is a moral value central to the idea of human rights; discrimination against any group should never be tolerated.

2. An Argentinian and an Australian are more likely to have differences in their DNA than two Argentinians

Groups of human beings have moved around throughout history. Those that share the same culture, language or location tend to have different genetic variations than other groups. This is becoming less true, though, as populations mix.

3. A person’s history isn’t written only in his or her genes

Everyone’s genetic material carries a useful, though incomplete, map of his or her ancestors’ travels. Studies looking for health disparities between individuals shouldn’t rely solely on this identity. They should also consider a person’s cultural background.

4: Members of the same race may have different underlying genetics

Social definitions of what it means to be “Hispanic” or “black” have changed over time. People who claim the same race may actually have very different genetic histories.

5. Both nature and nurture play important parts in our behaviors and abilities

Trying to use genetic differences between groups to show differences in intelligence, violent behaviors or the ability to throw a ball is an oversimplification of much more complicated interactions between genetics and environment.

6. Researchers should be careful about using racial groups when designing experiments

When scientists decide to divide their subjects into groups based on ethnicity, they need to be clear about why and how these divisions are made to avoid contributing to stereotypes.

7. Medicine should focus on the individual, not the race

Although some diseases are connected to genetic markers, these markers tend to be found in many different racial groups. Overemphasising genetics may promote racist views or focus attention on a group when it should be on the individual.

8. The study of genetics requires cooperation between experts in many different fields

Human disease is the product of a mishmash of factors: genetic, cultural, economic and behavioral. Interdisciplinary efforts that involve the social sciences are more likely to be successful.

9. Oversimplified science feeds popular misconceptions

Policy makers should be careful about simplifying and politicising scientific data. When presenting science to the public, the media should address the limitations of race-related research.

10. Genetics 101 should include a history of racism

Any high school or college student learning about genetics should also learn about misguided attempts in the past to use science to justify racism. New textbooks should be developed for this purpose.

The Stanford group didn’t always agree when coming up with these ideas. Predictably enough, the biomedical scientists tended to think of race in neutral, clinical terms; the social scientists and scholars of the humanities argued that concepts of race cannot be washed clean of their cultural and historical legacies.

But both groups, according to the letter, recognise the power of the gene in the public imagination and the historical dangers of its misrepresentation as deterministic and immutable.

Journal reference: Genome Biology (DOI: 10.1186/gb-2007-9-7-404)

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