Disturbing video reveals the moment a deadly explosion detonated in a busy shopping district in the heart of Istanbul, killing five people the fourth suicide attack in Turkey so far this year.

The video shows a woman waving goodbye as she walks across a road before the bomb wreaks havoc in the city.

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CCTV video shows a woman waving goodbye as she walks across a road before a bomb wreaks havoc in Istanbul. Photo: YouTube/RT

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Photo: YouTube/RT

Five people were killed and 36 were wounded in the attack.

Prime Minister Ahmet Davutoglu said Saturday's blast was "inhumane" and would not stop Turkey, which has been targeted by Kurdish militants and Islamic State in recent months, from fighting "centres of terrorism".

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Photo: YouTube/RT

The blast, which wounded at least 36 people, was a few hundred metres from an area where police buses are often stationed and sent panicked shoppers scurrying into alleys off Istiklal Street, a pedestrian avenue lined with international stores and foreign consulates.

The explosion killed at least two Israeli citizens, Prime Minister Benjamin Netanyahu said, adding that a third may have died. Israel said earlier that 11 of its citizens were injured while Turkish officials said one Iranian was also among the dead. Ireland said "a number" of Irish were hurt.

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