The wife of the Uzbeki national accused of murdering eight people in Manhattan denied any knowledge of her husband’s carefully planned rampage, according to a report.

A person who spoke to Sayfullo Saipov’s 24-year-old wife, Nozima Odilova, on Tuesday evening said she seemed “shocked and horrified and scared and sad” after being grilled by the FBI, a source told the Washington Post.

At the time, the feds were at her Paterson, NJ, house, where they encouraged her to cooperate to make sure no one else was harmed.

Meanwhile, neighbor Carlos Batista recounted that Saipov had occasionally driven a Home Depot pickup truck on the block with a couple of pals — apparently with no building materials aboard.

“They didn’t even have one piece of wood in there, and that’s why I found it a little suspicious,’’ Batista told the Washington Post. “And I do construction, so I know when somebody is doing some type of work.’’

Authorities suspect the early rentals were part of the ISIS sympathizer’s preparation for the attack he carried out Tuesday — running down bicyclists and pedestrians on a lower Manhattan bike path.

According to a criminal complaint filed Wednesday night, Saipov rented the truck Oct. 22 to practice making turns with the vehicle in preparation for the attack.

The document said Saipov confessed that he began planning for it about a year ago.

Other neighbors on Genessee Avenue where Saipov lived said nothing struck them as unusual about the 29-year-old father of three young kids.

Altana Dimitrovska, who lives in the same complex, said she was surprised by the news about the carnage.

Speaking through a translator, Dimitrovska said she once asked him if he ever went to work, because she would see him walking around a lot.

“He said, ‘Yeah, I do go to work.’ But I never saw him going to work,’’ she said. Asked whether she ever saw anything suspicious about Saipov, the 63-year-old woman replied, “No, no, no.’’