Our study shows that the eastern Mediterranean region is going through a crucial health phase. The Arab uprisings and the wars that followed, coupled with ageing and population growth, will have a major impact on the region's health and resources. The region has historically seen improvements in life expectancy and other health indicators, even under stress. However, the current situation will cause deteriorating health conditions for many countries and for many years and will have an impact on the region and the rest of the world. Based on our findings, we call for increased investment in health in the region in addition to reducing the conflicts.

The leading cause of death in the region in 2013 was ischaemic heart disease (90·3 deaths per 100 000 people), which increased by 17·2% since 1990. However, diarrhoeal diseases were the leading cause of death in Somalia (186·7 deaths per 100 000 people) in 2013, which decreased by 26·9% since 1990. The leading cause of disability-adjusted life-years (DALYs) was ischaemic heart disease for males and lower respiratory infection for females. High blood pressure was the leading risk factor for DALYs in 2013, with an increase of 83·3% since 1990. Risk factors for DALYs varied by country. In low-income countries, childhood wasting was the leading cause of DALYs in Afghanistan, Somalia, and Yemen, whereas unsafe sex was the leading cause in Djibouti. Non-communicable risk factors were the leading cause of DALYs in high-income and middle-income countries in the region. DALY risk factors varied by age, with child and maternal malnutrition affecting the younger age groups (aged 28 days to 4 years), whereas high bodyweight and systolic blood pressure affected older people (aged 60–80 years). The proportion of DALYs attributed to high body-mass index increased from 3·7% to 7·5% between 1990 and 2013. Burden of mental health problems and drug use increased. Most increases in DALYs, especially from non-communicable diseases, were due to population growth. The crises in Egypt, Yemen, Libya, and Syria have resulted in a reduction in life expectancy; life expectancy in Syria would have been 5 years higher than that recorded for females and 6 years higher for males had the crisis not occurred.

GBD 2013 includes an annual assessment covering 188 countries from 1990 to 2013. The study covers 306 diseases and injuries, 1233 sequelae, and 79 risk factors. Our GBD 2013 analyses included the addition of new data through updated systematic reviews and through the contribution of unpublished data sources from collaborators, an updated version of modelling software, and several improvements in our methods. In this systematic analysis, we use data from GBD 2013 to analyse the burden of disease and injuries in the eastern Mediterranean region specifically.

The eastern Mediterranean region is comprised of 22 countries: Afghanistan, Bahrain, Djibouti, Egypt, Iran, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Pakistan, Palestine, Qatar, Saudi Arabia, Somalia, Sudan, Syria, Tunisia, the United Arab Emirates, and Yemen. Since our Global Burden of Disease Study 2010 (GBD 2010), the region has faced unrest as a result of revolutions, wars, and the so-called Arab uprisings. The objective of this study was to present the burden of diseases, injuries, and risk factors in the eastern Mediterranean region as of 2013.

In this Article, we present the burden of diseases, injuries, and risk factors in the eastern Mediterranean region from 1990 to 2013, with the aim to show the impact of war and unrest on the health of people in the region as of the end of 2013.

The political and economic situation in the region since 2010 has suffered from continued unrest and the Arab uprisings. Revolutions and changes in government occurred in Egypt, Libya, Tunisia, and Yemen. A civil war is devastating Syria, and disturbances are common in Afghanistan, Bahrain, Iraq, Palestine, and Somalia. As a result, hundreds of thousands of civilians have been forced to flee and seek refuge.

The eastern Mediterranean region is comprised of 22 countries: Afghanistan, Egypt, Bahrain, Djibouti, Iraq, Iran, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Pakistan, Palestine, Qatar, Saudi Arabia, Somalia, Sudan, Syria, Tunisia, the United Arab Emirates, and Yemen. The region has a population of about 583 million people.Countries in the eastern Mediterranean region vary substantially in their gross domestic product, sociodemographic profiles, health indicators, and health system capacities and coverage.

The state of health in the Arab world, 1990–2010: an analysis of the burden of diseases, injuries, and risk factors.

The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility to submit the paper.

We cross-tabulated the quantiles of disability-adjusted life-years (DALYs) by quintiles of annual DALY increase from 1990 to 2013 to show rates of DALY increase by burden. We divided the region into three categories according to the gross national income (GNI) per capita. The first category represents the low-income countries with an average GNI per capita of US$523·3 On the opposite end of the spectrum are oil-rich, high-income countries with an average GNI per capita of $39 688. The nations that lie in between are the middle-income countries with an average GNI per capita of $3251, which can be further subdivided into lower-middle-income and upper-middle-income countries. Low-income countries were Afghanistan, Djibouti, Somalia, and Yemen. Middle-income countries were Egypt, Iran, Iraq, Jordan, Lebanon, Libya, Morocco, Pakistan, Palestine, Sudan, Syria, and Tunisia. High-income countries were Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates.

We used the comparative risk assessment approach to evaluate how much of the burden of disease observed in a given year can be attributed to past exposure to a risk factor.We estimated attributable burden by comparing observed health outcomes with outcomes that would have been observed if an alternative or counterfactual level of exposure had taken place in the past. We used the exposure level that minimises risk for the population, termed the theoretical minimum risk exposure level. We avoided double counting in the presentation of overall results by computing the overlap for joint risk distributions: behavioural risks alone; environmental or occupational risks alone; metabolic risks alone; behavioural and environmental or occupational risks together; behavioural and metabolic risks together; environmental or occupational and metabolic risks together; and behavioural, environmental or occupational, and metabolic risks together.

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.

We generated child mortality rates and adult mortality rates under the influence of natural disasters and armed conflicts as previously described.Because of ongoing unrest and war, some datapoints needed for our analyses were not available. A list of all datapoints used in this study are available on our Global Health Data Exchange web page. When data were unavailable, we relied on our ensemble modelling techniques to generate the estimates using other available variables and the information for neighbouring countries or countries with a similar health profile in the region. We used six different modelling strategies for the 240 causes of death using our cause-of-death ensemble model for causes with sufficient information. We estimated national time series from 1950 to 2013 for gross domestic product, educational attainment, tobacco prevalence, and obesity. For mortality rates of children younger than 5 years, we analysed all survey, census, sample registration, and vital registration sources. Wherever possible, we analysed microdata from surveys and censuses with updated methods for child mortality. We corrected for bias in different sources in specific countries. For adult mortality, we identified all available vital registration data, sibling history survey data, sample registration data, and household recall of deaths. We assessed vital registration data for completeness and analysed sibling history data to account for survivor bias, zero-surviving sibships, and recall bias. We used spatiotemporal regression and Gaussian process regression to synthesise all measurements of mortality. We used UN population estimates that account for migration in our analyses. Moreover, we applied mortality shocks based on multiple reports to our analyses.

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.

The eastern Mediterranean region is facing numerous health challenges, as a result of previous wars, revolutions, the wars that followed, and ageing and population growth. These challenges will have a major impact on health outcomes and available resources. The region has historically seen improvements in life expectancy and other health indicators even under stress. However, according to our study, the current situation has resulted in deteriorating health conditions for many countries that are threatening these gains and will have an impact on the region and the rest of the world. On the basis of our data, we call for increased investment in health in the region and the end of ongoing conflicts.

GBD 2013 includes an annual assessment covering 188 countries, from 1990 to 2013. It covers 306 diseases and injuries, 1233 sequelae, and 79 risk factors. GBD 2013 included key methodological differences from GBD 2010, which were inclusion of new data through updated systematic reviews and through the contribution of unpublished data sources from many collaborators; use of a counterfactual approach for estimating diarrhoea and pneumonia causes; elaboration of the sequelae list to include asymptomatic states; use of more detailed nature of injury codes (N-codes); improvements to the Bayesian meta-regression method; increased simulation size for comorbidity; estimation of the prevalence of injuries by cohort; and use of a new method to estimate the distribution of mild, moderate, and severe anaemia by cause. This study provides an overview of the comprehensive burden of diseases and risk factors for the eastern Mediterranean region.

The Global Burden of Disease Study 2010 (GBD 2010) became available in 2012. GBD 2010 reported on disability-adjusted life-years (DALYs), health-adjusted life expectancy, and 67 risks and risk clusters by 21 world regions and 188 countries. GBD 2010 covered 20 age and sex groups.

The Global Burden of Disease Study 2013 (GBD 2013) includes an annual assessment covering 188 countries from 1990 to 2013. It covers 306 diseases and injuries, 1233 sequelae, and 79 risk factors. Detailed descriptions of the method and approach of GBD 2013 have been published elsewhere.Key changes in the methods from GBD 2010 are the inclusion of new data through updated systematic reviews and the contribution of unpublished data sources from various collaborators; the use of a counterfactual approach for estimating causes of diarrhoea and pneumonia; elaboration of the sequelae list to include asymptomatic states; use of more detailed nature of injury codes (N-codes); improvements to the Bayesian meta-regression method; increased simulation size for comorbidity; estimation of the prevalence of injuries by cohort; and use of a new method to estimate the distribution of mild, moderate, and severe anaemia by cause. In this systematic analysis, we use data from GBD 2013 to analyse the burden of disease and injuries in the eastern Mediterranean region specifically. We report 95% uncertainty intervals for each value in our analysis.

Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013.

Projected life expectancy using figures from 2009 until 2013, based on the trends observed from 1990 to 2008 compared with observed life expectancy from GBD 2013 are shown in Figure 2 Figure 3 . From 1990 to 2010, Egypt, Libya, Syria, and Yemen had a steady increase in life expectancy of about 0·25 years per year, with a slightly higher increase in females (about 0·3 years) than in males. However, Egypt, Tunisia, and Yemen have lost about 0·25 years of life expectancy due to the uprising that began in 2010. When comparing observed life expectancy to expected life expectancy if no crisis had occurred, we found a large decrease in life expectancy in Libya of more than 9 years for males and 6 years for females. Conversely, a steady decrease in life expectancy was observed in Syria because of the continuing war. Therefore, between 1990 and 2013 life expectancy for Syria would have been 6 years higher than observed for males and 5 years higher for females had the crisis not happened. Moreover, our analyses showed that several countries in the region have experienced a slow-down in lowering infant mortality rate. For example, in Syria the annualised rate of reduction in infant mortality between 2010 to 2013 was −9·1%, in sharp contrast with the rate of decrease of 6·0% before 2010.

Decomposition tables for the impact of ageing and population growth on the changes in DALYs from communicable diseases, non-communicable diseases, and injuries for the region are shown in table 3 , and in the appendix (pp 18–21) for low-income, middle-income, and high-income countries. DALYs caused by non-communicable diseases and injuries increased (mainly because of population growth), whereas DALYs caused by communicable diseases decreased, although the actual rates of DALYs decreased for all risk factors ( table 3 ).

Decomposition of the change of DALYs by cause into contributions from total population growth, population ageing, and changes in age-specific, sex-specific, and cause-specific DALY rates for the eastern Mediterranean region; 1990–2013

Table 3 Decomposition of the change of DALYs by cause into contributions from total population growth, population ageing, and changes in age-specific, sex-specific, and cause-specific DALY rates for the eastern Mediterranean region; 1990–2013

The annualised rates of change for DALY risk factors by burden for the region, low-income, middle-income, and high-income countries are shown in the appendix (pp 3–6) . DALYs per 100 000 people attributed to high body-mass index increased by 28% from 1990 to 2013 (from 1961 years per 100 000 people to 2506 years per 100 000 people) and accounted for over 7·3% of total DALYs.For high-income countries, high fasting plasma glucose, high body-mass index, alcohol use, and drug use accounted for the highest annual increase with a high DALYs burden.

High blood pressure was the leading risk factor for DALYs in 2013, which increased by 83·3% from 1990 (from 8·5 million to 16·1 million DALYs; table 2 however, the number of DALYs per 100 000 people increased by only 14%. High blood pressure increased from the fifth highest cause of DALYs in 1990 to first in 2013. Risk factors for DALYs varied by country, with childhood wasting as the leading cause in Somalia, Afghanistan, and Yemen, whereas unsafe sex was the leading cause of DALYs in Djibouti. Conversely, non-communicable disease risk factors were the leading cause of DALYs in high-income countries and middle-income countries ( figure 1 ). DALY risk factors varied by age; child malnutrition and suboptimal breastfeeding affected the younger age groups (aged 7 days to 4 years) and high bodyweight and systolic blood pressure affected the older age groups (aged 60–80 years; appendix p 2 ).

Overall, regional DALYs decreased from 54 838 years per 100 000 people in 1990 to about 34 217 years per 100 000 people in 2013. DALYs vary disproportionately by age and sex. Children younger than 5 years contributed to about 33% of total DALYs with a rate of 94 884 years per 100 000 people, compared with 34 217 years per 100 000 people for the general population.Ischaemic heart disease was the leading cause of DALYs in the region in 2013 in males and when data for both sexes were combined, whereas diarrhoeal diseases were the leading cause in 1990 ( table 1 ). Lower respiratory infection was the leading cause of DALYs for females. Causes of DALYs varied by income; lower respiratory infection was the leading cause of DALYs in low-income countries ( appendix p 15 ), ischaemic heart disease in middle-income countries ( appendix p 16 ), and road injuries in high-income countries ( appendix p 17 ). Causes of DALYs and their change from 1990 by country varied widely ( appendix p 11 ). Causes of DALYs varied by age. For example, DALYs for mental health peaked in early adulthood and declined with age, whereas DALYs for cardiovascular diseases and neoplasms increased with age ( appendix p 1 ). Different patterns of DALYs were observed in different income levels ( appendix pp 12–14 ).

Overall, regional years lived with disability (YLDs) increased from 9526 years per 100 000 people in 1990 to about 10 057 years per 100 000 people in 2013.Musculoskeletal disorders and mental disorders and substance abuse were major contributors to YLDs in 2013 and had the highest increase ( appendix p 10 ). Nutritional deficiencies (mainly iron-deficiency anaemia) decreased in the region overall, but remained a large burden in low-income countries. For example, nutritional deficiencies remained one of the leading causes of YLDs in Yemen although the YLDs per 100 000 people decreased slightly by 2% from 1990.

There was a change in causes of years of life lost (YLLs) from 1990 to 2013 in all countries ( appendix p 9 ). Overall, regional YLLs decreased from 45 312 years per 100 000 people in 1990 to about 24 160 years per 100 000 people in 2013.Cardiovascular diseases, neoplasms, diabetes, chronic kidney disease, and transport injuries increased, especially in high-income and middle-income countries in the region, whereas neonatal disorders, diarrhoeal diseases, and lower respiratory infections decreased. HIV/AIDS and tuberculosis were large contributors to YLLs in 2013 in Djibouti. War was a large contributor to YLLs in Syria in 2013 (38·1% of total YLLs).

The leading cause of death in the eastern Mediterranean region in 2013 was ischaemic heart disease (90·3 deaths per 100 000 people).It surpassed both diarrhoeal diseases and lower respiratory infections as the leading cause of death in 1990, increasing by 17·2%. There was a shift in main causes of death from communicable to non-communicable diseases in the region. Causes of death and their rates of change varied by country.For example, diarrhoeal disease was the leading cause of death in Somalia and accounted for 186·7 deaths per 100 000 people in 2013, a decrease of 26·9% from 1990.All countries observed an increase in life expectancy and healthy life expectancy since 1990, although at different rates ( appendix pp 7–8 ). Afghanistan had the lowest life expectancy and healthy life expectancy (56·5 years vs 49·0 years for men, 56·0 years vs 48·8 years for women, respectively), whereas Qatar had the highest (81·2 years vs 69·2 years for men, 83·1 years vs 69·5 years for women, respectively). Lebanon had a higher increase in healthy life expectancy than life expectancy. Global life expectancy for both sexes increased from 65·3 years in 1990, to 71·5 years in 2013.

Discussion

The eastern Mediterranean region is facing numerous health challenges as a result of previous wars, recent revolutions, and the wars that followed, and of ageing and population growth. Life expectancy at birth in the region increased from 65 years in 1990 to 71 years in 2013, with an annual increase of about 0·26 years. However, according to our study, the situation has resulted in deteriorating health conditions for many countries that are threatening these gains and will have an impact on the region and worldwide. Hence, on the basis of our results, we call for increased investment in health in the region, and suppression of the conflicts.

10 El Chammay R

Ammar W Syrian crisis and mental health system reform in Lebanon. , 11 Supreme Council of Health (Qatar) Our study showed a rapid increase in the burden of mental and drug-use disorders in the region. Unfortunately, the rise in burden of mental health problems has not been met with investment in prevention by most countries in the region, with few exceptions, such as Lebanon and Qatar.Mental health is not viewed as a major burden by many countries and is not discussed in the agendas of many international agencies and health ministries. We hope that our findings will shed light and lead to more attention by global and regional health agencies to tackle this rising burden.

12 Mokdad AH

Tuffaha M

Hanlon M Cost of diabetes in the Kingdom of Saudi Arabia, 2014. Similarly, the rapid rise in non-communicable diseases is alarming. Diabetes, for example, is a heavy burden on many countries, with deaths increasing from 12 to 19 per 100 000 people. One studyshowed a high cost of diabetes in Saudi Arabia. These trends, irrespective of their cause, will lead to a strain on finances and human resources in a region where they are already scarce. The prevention and control of risk factors associated with non-communicable diseases should be a priority for the region.

13 Ahmed QA

Arabi YM

Memish ZA Health risks at the Hajj. 14 Al-Lami F

Al-Fatlawi A

Bloland P

et al. Pattern of morbidity and mortality in Karbala hospitals during Ashura mass gathering at Karbala, Iraq, 2010. 15 Hui DS

Perlman S

Zumla A Spread of MERS to South Korea and China. The spread of communicable diseases in the eastern Mediterranean region is of concern. The Hajj annual pilgrimage presents a challenge to health planners. The mass gathering for Hajj has led to several outbreaks of infectious disease such as meningitis and polio in Saudi Arabia and other countries.Moreover, the gathering in Iraq for Ashura, a day of mass mourning, has the same potential for the spread of disease.In most of these countries, kissing is a normal way of greeting people, and sharing food and social congregations are common. This cultural behaviour has complicated efforts to control Middle East respiratory syndrome (MERS) outbreaks in Saudi Arabia and its spread to other countries.Containment and control of emerging diseases and infections in the eastern Mediterranean region is a national interest for all countries.

16 Centers for Disease Control and Prevention

Psychological and emotional effects of the September 11 attacks on the World Trade Center—Connecticut, New Jersey, and New York, 2001. 17 Amnesty International

The application of the death penalty for drug-related offences and its serious impact on the enjoyment of human rights. Our study showed a rise in the burden of disease due to illicit drugs in the region. Several studies have reported that, during stress, individuals might engage in risky behaviours.Unfortunately, the response of many countries has been law enforcement measures and strict punishment.The region is in need of comprehensive socioculturally appropriate approaches towards education, prevention, and early identification and treatment.

18 WHO Road-traffic injuries are the leading cause of DALYs in men in high-income countries throughout the region, and rank increasingly higher in low-income and middle-income countries than in previous years. Unfortunately, many countries in the region have yet to fully implement policies and legislation conducive to road safety, and need to strengthen their trauma care systems.

19 Schär C Climate extremes: the worst heat waves to come. One of the main challenges and threats for the region is the environment. Most countries in the region are facing water shortages due to population pressure, increasing water demand, and natural climate variability. Moreover, climate change has resulted in increased temperatures in the region, and a major part of the eastern Mediterranean region is projected to be uninhabitable in the next 50–80 years.Additionally, most countries in the region are not food sufficient and rely heavily on imports to meet growing demands. Development of a plan to address these issues is crucial for the region and the world, because they will affect the stability and future of the region.

20 Mohammed bin Rashid Al Maktoum Foundation UNDP Regional Bureau for Arab States

Arab knowledge report 2014. Youth and localisation of knowledge. Unrest, civil conflicts, and wars have had a big impact on the burden of disease in the eastern Mediterranean region. However, the long-term impact of the unrest is not yet known. The region is losing its health talents, as many medical doctors and health professionals leave conflict areas in search of a better life elsewhere.Moreover, historically high rates of unemployment in the region have caused many other people to seek work elsewhere.

Many countries in the region are facing other health challenges that they are not equipped for. For example, the conflict in Syria has resulted in millions of individuals being displaced internally and millions of others forced to seek refuge in neighbouring countries. Only when an influx of Syrian refugees into Europe occurred did this crisis receive widespread media coverage. There is a need for long-term planning to improve the health of and stabilise the region.

The infrastructure in several of these countries has been destroyed because of war. Water and sanitation will pose major challenges until proper reconstruction is achieved. Unfortunately, these effects will lead to an increased rate of disease spread and outbreaks, which must be properly controlled. Moreover, investment in health information systems in the region is urgently needed. This investment should be a priority for countries and donors once the political situation improves.

Our study showed that many of the health gains achieved by countries in the region are at risk of slowing down. In fact, infant mortality has risen in some countries. It is sad to see that Syria, a country with a good performance in reducing child mortality in the past, saw a rise from 2010 to 2013. Syria is falling behind countries in sub-Saharan Africa when it comes to the rate of change in infant mortality.

The political situation in the region continues to be uncertain; since 2013, the wars in Syria and Libya have escalated, and a war has started in Yemen. In some areas, residents are facing starvation and the public health and medical systems are about to collapse. Moreover, wars and unrest in Afghanistan, Iraq, Palestine, and Somalia have continued or re-emerged, and for many people in these countries, survival is the main challenge, not health. The eastern Mediterranean region is facing several health challenges at a time of uncertainty, and the countries in this region are struggling to meet these challenges.

Events in the past 5 years have shown that the wellbeing of people in the eastern Mediterranean region crosses beyond its borders, as exemplified by the spread of MERS to South Korea and the outbreak of infectious diseases in refugee camps in Lebanon and Jordan. A healthy eastern Mediterranean region is a politically stable eastern Mediterranean region, one from which the whole world will benefit. Based on our findings, we call for stepping up efforts at the regional and local levels to improve health, identify barriers to scaling up health promotion and disease prevention services, and to stabilise the region.