SANTA CLARA — All-Pro linebacker Patrick Willis injured his right hand early in the 49ers’ practice Wednesday and did not participate in the ensuing team drills.

Coach Jim Harbaugh and general manager Trent Baalke individually checked on Willis, who remained on the field and watched practice with his hand heavily wrapped, presumably with ice.

Trainers examined Willis’ his wrist region during a one-on-one blocking drills between linebackers and running backs.

Michael Wilhoite, a second-year veteran, replaced Willis on the first-team unit during early red-zone drills. Lining up next to Wilhoite was NaVorro Bowman, who missed Tuesday’s session with an apparent groin strain.

Willis has made the Pro Bowl each of his six seasons, and made the Associated Press’ First Team All-Pro for a fifth time last season as the 49ers reached Super Bowl XLVII.

Outside linebacker Aldon Smith, who had a franchise record 19½ sacks last season, was not practicing Wednesday for the first time this training camp. Smith came out to watch practice in shorts and showed no visible signs of injury, although he had labrum surgery this offseason.

Others not practicing were wide receivers A.J. Jenkins, Kyle Williams and Kassim Osgood, all of whom are battling recent leg injuries. Center Jonathan Goodwin was not at practice for a second straight day, although he was at the facility and his health status is unknown.

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