With the official release of the 2018 NFL schedule on Thursday night, Los Angeles Rams fans finally got to see when some of the premier matchups will take place. Although the Rams’ opponents have been known for some time due to the NFL’s formulaic scheduling, the dates of all the big games are now known.

Here are the five most important games on the schedule in terms of their on-field significance and the media hype surrounding them:

5. Chiefs @ Rams (Mexico City) – Week 11: 11/19

The last time the Rams had a game outside the U.S., it was a beatdown. The Rams demolished the Cardinals in last year’s London game from start to finish. They’ll look to continue that foreign success when they take on the Chiefs in Mexico City on Monday Night Football.

The Chiefs are one of the biggest question marks of the 2018 season. After starting off 5-0, they faded down the stretch and collapsed against the Titans in the AFC wild-card game. They shipped off Alex Smith to the Redskins and will be moving forward with Patrick Mahomes at quarterback. Last year’s No. 10 overall pick, Mahomes has flashed tons of potential. Mahomes vs. Jared Goff should be an exciting duel for fans abroad as two of the youngest and most promising quarterbacks in the league.

Another interesting element of the now annual Mexico City game is the elevation. The high altitude can allow teams to attempt field goals they usually never would. Get ready to see Greg Zurlein firing away a 60-yarder.

4. Chargers @ Rams – Week 3: 9/23

#FightforLA. After much effort from various marketing departments to turn the return of professional football to L.A. into a rivalry, the two teams will finally meet.

The Rams have the advantage of hosting the first game. Which of these teams is first to become a consistent winner could go a long way in determining where fan loyalties in the city lie years from now, so it’s an important game. As the Clippers can attest, it’s not great being little brother in Los Angeles. The Chargers were much better than their record last year, and the Rams will need to avoid getting caught sleeping. The Chargers have serious playoff aspirations themselves and it’ll be a hard-fought battle. It’ll be interesting to see how the Rams’ new and improved offensive line fares against Joey Bosa and Melvin Ingram.

It should be a fun game, and there will definitely be some extra motivation for both sides.

3. Vikings @ Rams – Week 4: 9/27

The Rams will face another difficult challenge just four days later. They’ll play Minnesota at home on Thursday night in one of their five primetime games.

The last time the Rams played on Thursday Night Football, it was a thrilling game. It ended with a Rams victory, as they escaped San Francisco with a 41-39 shootout win. Ex-Ram Case Keenum won’t be the quarterback for Minnesota this time, but it should a very interesting game. Kirk Cousins will be playing in his fourth game as a Viking, and his first in primetime.

The Vikings are looking to build on their NFC Championship game run last season. The Rams are looking to prove early on that last season wasn’t a fluke. This game very likely could have playoff seeding implications and will be a tough challenge on just three days rest.

2. Eagles @ Rams Week 15 – 12/23

A rematch of one of the best games of the 2017 season, and although it was mostly remembered as the game Carson Wentz got hurt, it was a great game before that. The Week 14 loss featured a devastating blown lead, but was extremely entertaining, nonetheless.

As the first two picks of the 2016 draft, the Goff vs. Wentz matchup will always be interesting. On top of that, both teams have legitimate Super Bowl aspirations. Coming this late in the season, the game is almost certain to have playoff implications.

It’ll be the fifth and final primetime game of the season, on NBC for Sunday Night Football.

1. Rams @ 49ers – Week 7: 10/21

Although the matchup is far from unique because they meet twice every season, it’s been a while since the Rams had a true division rivalry. The new-look Rams and revamped 49ers have both been among the offseason’s biggest storylines, and both teams enter the season with sky-high expectations. With new franchise-quarterback Jimmy Garoppolo under center, the 49ers are looking to continue their momentum from last year. After starting the season 1-10 with Bryan Hoyer and C.J. Beathard at quarterback, Garoppolo led them to five straight wins to finish the season.

With the amount of youth on both of these teams, many analysts have predicted a potential decade-long fight for supremacy atop the NFC West. The burgeoning rivalry features two of the brightest young offensive minds in the game in coaches Kyle Shanahan and Sean McVay. It will also be Garoppolo’s first real start against these Rams since the Rams rested almost all of their starters during last season’s Week 17 game.

With a victory here, the Rams have the potential to set the tone in the division and cement themselves as top dogs in the NFC West.

The bottom line:

Overall, it’s a tough schedule. The Rams are playing in what is now potentially the toughest division in the NFL. On top of that, there’s no shortage of challenges on the non-division slate. In order to repeat or improve on their 11-5 record from last year, they’ll have to get through a slew of playoff teams. They’ll be doing it all on a national stage, with an insane five primetime nationally televised games.