One man has been killed and three others seriously wounded after a gunman opened fire in a 'targeted attack' in a downtown Ottawa Airbnb apartment this morning.

Ottawa Police and paramedics were called to the 400 block of Gilmour Street shortly before 7:30am to reports of shots fired that had caused 'many injuries'.

In a statement, the police department confirmed that a man had been killed at the scene and three others were taken to hospital with severe injuries.

One of the victims is a 15-year-old boy and he was taken to the Children's Hospital of Eastern Ontario for treatment in a stable condition.

The other victims are both male and are said to be in a 'serious' condition'.

Police say a 'coordinated response' is currently underway, and said the gunman remains at large as they 'continue to seek a suspect in this shooting'.

Ottawa Police and paramedics were called to the 400 block of Gilmour Street shortly before 7:30am to reports of an active shooter that had caused 'many injuries' (credit: Ottawa Matters)

One of the victims is a 15-year-old boy and he was taken to the Children's Hospital of Eastern Ontario for treatment in a stable condition

Local resident Mark Ignatiev told CTV News that the home where the shooting took place is an Airbnb with three apartments spread across two floors. He said the shooting took place on the first floor

Police said a 'coordinated response' is currently underway. They have not yet confirmed whether the shooter is still active

'The scene at Gilmour Street has been secured by police,' Ottawa police said in a news release. 'This is not considered an active shooter situation, but the suspect remains at large and is not in custody.'

Inspector Francois D'Aoust said authorities don't yet have a description of the suspect but officers are going door-to-door in the area to gather more information.

The motive of the shooting remains unknown, though police have said they believe the attack was a 'targeted shooting'. The incident took place on a residential street.

'Major Crime investigators have confirmed that there are no national security implications related to this incident,' a later statement released by the department confirmed.

Local resident Mark Ignatiev told CTV News that the home where the shooting took place is rented out as an Airbnb with three apartments spread across two floors. He said the shooting took place on the first floor.

The motive of the shooting remains unknown, though police have said they believe the attack was a 'targeted shooting'. The incident took place on a residential street

Inspector Francois D'Aoust said authorities don't yet have a description of the suspect but officers are going door-to-door in the area to gather more information

Kacey Griffiths, who lives next to the house were she shooting occurred, said she awoke to find heavily armed police surrounding the neighboring building. She observed police stretching two young people out of the home while they administered treatment to a third in the backyard

Ignatiev recalled seeing two people being escorted out of the home on stretchers, one with a wound to the leg and a second with a wound to his arm. One of the victims reportedly said he was 20-years-old when asked by police.

He says he then watched on as police apparently retrieved what looked like a gun from a neighboring yard.

Kacey Griffiths, who lives next to the house were she shooting occurred, said she awoke to find heavily armed police surrounding the neighboring building.

She observed police stretching two young people out of the home while they administered treatment to a third in the backyard.

'They were both people I've never seen before,' she told the network. 'I'm very local here and I know my neighbors. I've never seen these people in my life.'

Griffiths theorized the shooting may have been gang-related, citing a similar shooting in the street last May.

Canadian Prime Minister Justin Trudeau tweeted Tuesday afternoon confirming that he had spoken to Ottawa Mayor Jim Watson about the shooting.

'My heart goes out to everyone affected, and I hope all those injured have a speedy recovery,' Trudeau wrote. 'I’d also like to thank the @OttawaPolice & paramedics for acting so quickly.'

The scene of the shooting is less than a kilometre south of Parliament Hill. Police are urging people to avoid the area

The scene of the shooting is less than a kilometre south of Parliament Hill. Police are urging people to avoid the area.

An emergency message was sent out by the Parliament of Canada Protective Service to all federal government employees at 8:04am warning of an 'active shooter' who is still at large.

'Be advised: Active shooter near Gilmore St. and Kent St. Be vigilant. Shooter is still at large,' the message reads.

Gilmour Street remains closed between Kent and Lyon while the investigation is ongoing.

Anyone with information regarding this incident is asked to call the Ottawa Police Service Major Crime Unit at 613-236-1222, ext. 5493.

Anonymous tips can be submitted by calling Crime Stoppers toll-free at 1-800-222-8477 or at crimestoppers.ca.

This is a developing story