Secretary of State Mike Pompeo Michael (Mike) Richard PompeoThe Hill's Morning Report - Sponsored by The Air Line Pilots Association - Pence lauds Harris as 'experienced debater'; Trump, Biden diverge over debate prep Trump's foreign policy successes confound his detractors It's time for a Jackson-Vanik Amendment for China MORE said on Sunday that the U.S. is targeting “actual decision-makers” in Iran rather than Tehran's proxy forces.

Pompeo told ABC’s “This Week” that the Trump administration’s approach is different from past U.S. strategies that focused on combating proxy forces rather than the Iranian government itself.

“We’ve told the Iranian regime, enough,” he said. “You can’t get away with using proxy forces and think your homeland will be safe and secure.”

NEW: @GStephanopoulos presses Sec. of State Mike Pompeo on Trump's tweet warning cultural sites could be targeted if Iran retaliates: "Why is the president threatening Iran with war crimes?"



Pompeo: "We'll behave lawfully. We'll behave inside the system." https://t.co/gJwvmAsvm8 pic.twitter.com/thUzbapH0w — This Week (@ThisWeekABC) January 5, 2020

The secretary of State made the comments in the wake of the U.S. drone strike that killed Iranian Gen. Qassem Soleimani.

“We’re going to respond against the actual decision-makers, the people who are causing this threat from the Islamic Republic of Iran,” he said. “We’re going to take this seriously and we’re going to defend the American people at every turn.”

Pompeo’s comments come after a tumultuous two weeks for Washington and Iran that started with a strike that killed a U.S. contractor that the U.S. blames on an Iranian-backed militia. In response, the U.S. attacked the militia in Iraq.

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The secretary of State told ABC on Sunday that the U.S. will “behave lawfully” and only strike “lawful” targets.