A cyclist has died following a collision with a truck on a major road in Sydney's inner west.

Emergency services were called to Liverpool Road (Hume Highway) at Cosgrove Road in South Strathfield about 3.45pm on Wednesday afternoon.

The location of the accident. Credit:Google Maps

A spokesman for NSW Ambulance said the man in his 50s "appears to have gone under the truck" which was "turning left onto the Hume Highway".

He was unconscious and not breathing when paramedics arrived, and declared deceased at the scene, the spokesman said.