Washington (CNN) Emmanuel Macron may be known in the US for his close relationship to President Donald Trump, but in his address to Congress on Wednesday, the French President took aim at several key points of Trump's agenda.

Speaking before US lawmakers from both the Senate and the House, Macron pressed the United States to engage more in global affairs, contrasting with the steps the Trump White House has taken toward isolationism since he came into office.

Macron also pushed the US to rejoin the Paris Climate Agreement, which Trump announced his country would leave last year, and made the case for supporting the Iran nuclear deal, which Trump has sharply condemned.

"The 21st century has brought a series of new threats and new challenges that our ancestors might have never imagined," Macron said. "We can build the 21st century world order based on a new breed of multilateralism, based on a more effective, accountable, and results-oriented multilateralism."

He continued: "This requires more than ever the United States' involvement, as your role was decisive for creating and safeguarding this free world. The United States is the one who invented this multilateralism. You are the one who has to help now to preserve and reinvent it."

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