A call to police from a "concerned citizen" who saw a man behaving suspiciously with blood on his knuckles in Melbourne's south-east led to the discovery of a woman's body and the arrest of her partner.

The homicide squad is investigating the woman's death after her body was found in a Noble Park home on Douglas Street shortly after 9am on Monday.

Police had cordoned off the home and neighbouring properties on Monday. Credit:Morgan Hancock

Synai Saliu, 37, was arrested and remained in custody on Monday evening, being questioned by police.

"This morning there's been an incident between a male and a female, the occupants of an address. They are known to each other," said Acting Inspector Brendan Michael on Monday morning.