1. Salta, Argentina

The untrod northwest region of Argentina is the next big magnet for nature lovers: Condors fly above giant cactuses, snow-capped Andes mountains contrast with high desert, and ancient rock formations vie for attention with Indian ruins. It’s also an up-and-coming wine region with old vines and new, critically acclaimed wines that are largely unavailable outside the country. Oenophiles can taste at wineries—some clustered in Cafayete, not far from the well preserved city of Salta (founded in 1582)—and also hike or ride a horse through ancient Indian and Spanish culture.

2. Seattle

The...