Hollywood debut with Johnny Depp

The success of "Run Lola Run" also sparked Hollywood's interest in the German actress. In 2001, she featured in "Blow," by Ted Demme, starring Johnny Depp as a drug dealer. In the movie, Potente is his first love, an airline stewardess who smuggles marijuana for him. Her character dies from cancer 30 minutes into the film - but that was long enough for her to convince Hollywood of her talent.