Despite effective screening using cytology with and without high risk human papillomavirus DNA testing and validated prevention through HPV vaccination, invasive cervical cancer remains a global epidemic with 500,000 new diagnoses and 250,000 deaths worldwide each year. Incidence and mortality rates are highest in the poorest regions of the world. With respect to these poor nations, some progress has been made with locally-promoted cervical cancer screen-and-treat programs, utilizing the visual inspection with acetic acid (VIA) technique. While this work is promising and has shown to lead to reductions in disease specific mortality in countries that have implemented this practice, its only potential to adequately address the cervical cancer problem lies in its potential for sustainability. A limiting factor lies within the supply chain, with the vaginal speculum being resource-limiting due to both production costs and importation fees. Importantly, 3D-printing using plastic materials (e.g., water bottles) from some landfills of resource limited countries, such as within East Africa, has revolutionized the medical supply bottlenecks in many African communities through the printing of intravenous tubing and plastic bags for saline and medication distribution. We are currently developing a system to 3D-print vaginal speculums on site in poor resource settings, thereby circumventing one of the critical roadblocks to the sustainability of the cervical cancer screen and treat program. A pilot study was performed to evaluate the feasibility of such a program, and the 3D-printed speculum was more comfortable and achieved satisfactory cervical visualization in the majority. Additionally, it was found to be a cost-effective solution, with the price per 3D-printed vaginal speculum costing less than standard plastic speculums.