Journal Updates

ARNI for Heart Failure: Earlier Is Better

Earlier is better for the initiation of angiotensin receptor-neprilysin inhibition (ARNI) therapy in people hospitalized for acute decompensated heart failure (ADHF), according to data from the open-label extension phase of the 8-week PIONEER-HF trial.

Among patients with heart failure with reduced ejection fraction (HFrEF), those who were assigned sacubitril/valsartan (Entresto) right before discharge saw a further 17.2% decline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) during the 4-week extension, reported Adam DeVore, MD, MHS, of Duke Clinical Research Institute in Durham, North Carolina, and colleagues in JAMA Cardiology.