Even Banksy couldn’t save this graffiti landmark.

Furious street art fans were in mourning Tuesday after the owners of 5 Pointz had the graffiti Mecca in Long Island City whitewashed overnight.

“They’ve officially painted over 5 Pointz @5PointzNYC – my commute won’t be the same,” tweeted William McGinn, one of hundreds of supporters who took to Twitter to bemoan the loss.

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“WOW. 5 pointz is gone, painted white overnight by the owner with police protection,” added Dynamics.

The warehouse is owned by developers Jerry and David Wolkoff and will now face the wrecking ball.

Curators and managers of the project accused Jerry Wolkoff of purposely ruining the art to sabotage their efforts to get the building landmarked.

They said they were prepared to submit more than 20,000 landmark forms to the Landmarks Commission this week, 1,000 of which were collected during a rally on Saturday.

“It’s vandalism from the guys who want the building back,” said Marie Flageul, a lead organizer to save 5 Pointz. “This is a tragedy. It’s a signature Jerry Wolkoff move. If things don’t go his way, he takes them in his own hands. This is artistic murder.”

But Jerry Wolkoff and his lawyer defended his decision to whitewash the art – dooming the landmark effort – and knock down the building, insisting they were within their legal rights to move forward with their plan to build new condos.

“I know it seems like a bitter pill to take, but it’s medicine,” he told New York magazine. “All I did was the right thing.”

Wolkoff argued it would be easier for critics to swallow the ”medicine” in one dose rather than spread out the pain.

“The judge gave me the right to demolish my building. It would take three months. To watch the [art] pieces go down piece by piece by piece would be torturous. In New York, you can’t implode a building. So let me just go in and paint it in one morning, and it’s over with,” he said.

But it wasn’t an easy call, he added.

“I had tears in my eyes while I was doing it. In my new building I’ll have walls for them to express their aerosol art,” he said, adding that he requested a police presence because he didn’t want any confrontations between supporters and workers.

Wolkoff’s lawyer, David Ebert, added that the artists “knowingly painted with the understanding that their works would be replaced with other images, by other artists, within a short period of time.”

Flageul said the paint job was done between 1 and 7 a.m and that workers were guarded by cops, who kept people off the property as they finished the work.

Jonathan “Meres” Cohen, the building’s curator, said, “Tell Jerry I said I hope he’s happy. He destroyed the artwork and the biggest tourist attraction in Queens. I don’t care if he builds the tallest building in New York, nobody’s going to remember him for anything but that.”

in response to Wolkoff’s promise that the new development would have walls inside for artists to paint on, Cohen said, “Those walls will remain white. No artist will ever paint on anything you own again. “

Jake Fry, 40, neighborhood resident who works in wardrobe on Broadway , blasted the overnight move.

“Why did they do it in the night, so know no one would know, so no one could do anything about it? It’s a slap in the face. It’s just really upsetting. The owner insulted everyone around here and all the artists,” Fry said.

Flaguel said there were more than 1,500 pieces of art by more than 300 artists from around the world on the building.

Brooklyn federal Judge Frederic Block cleared the way for the work earlier this month, denying an attempt by artists and fans to preserve the graffiti.

Even the elusive British street artist Banksy got into the act during his October “residency” in the city, sending a supporter to hand out leaflets supporting 5 Pointz at the proceedings in Brooklyn Federal Court.