Democratic presidential candidates came prepared for battle on the second night of the Democratic presidential primary debates in Detroit on Wednesday.

Many of the candidates took on the front-runner of the 2020 Democratic race, former Vice President Joe Biden Joe BidenPelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Hillicon Valley: Subpoenas for Facebook, Google and Twitter on the cards | Wray rebuffs mail-in voting conspiracies | Reps. raise mass surveillance concerns Fox News poll: Biden ahead of Trump in Nevada, Pennsylvania and Ohio MORE, head-on in an effort to get a breakout moment. Sen. Kamala Harris Kamala HarrisHundreds of lawyers from nation's oldest African American sorority join effort to fight voter suppression Biden picks up endorsement from progressive climate group 350 Action 3 reasons why Biden is misreading the politics of court packing MORE (D-Calif.) also came under attack after swiftly climbing up in the polls over the past month.

The forum also witnessed some witty one-liners, with references to two popular U.S. brands.

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Here are the top moments from Wednesday's Democratic primary debate.

Booker takes on Biden

Sen. Cory Booker Cory Anthony Booker3 reasons why Biden is misreading the politics of court packing Bipartisan praise pours in after Ginsburg's death DHS opens probe into allegations at Georgia ICE facility MORE (D-N.J.) gave a preview of his attacks on the former vice president last week when he hit him over criminal justice reform, and followed through Wednesday when he delivered a series of blows to Biden on the debate stage.

Booker slammed Biden for criticizing his record on fighting crime as the mayor of Newark, N.J..

“There’s a saying in my community: You’re dipping into the Kool-Aid and you don’t even know the flavor," Booker said.

The line quickly gained traction on social media, even eliciting a reaction from Kool-Aid's Twitter account.

Booker accused Biden of invoking his former boss, President Obama, too much on the campaign trail.

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“Mr. Vice President, you can’t have it both ways,” Booker said at Wednesday night's primary debate in Detroit. “You invoke President Obama more than anybody in this campaign. You can’t do it when it’s convenient and then dodge it when it’s not.”

The moment came after Biden said that he would not reveal his private conversations with President Obama when pressed by former New York City Mayor Bill de Blasio Bill de BlasioOVERNIGHT ENERGY: California seeks to sell only electric cars by 2035 | EPA threatens to close New York City office after Trump threats to 'anarchist' cities | House energy package sparks criticism from left and right EPA threatens to close New York City office after Trump threats to 'anarchist' cities New Year's Eve in Times Square to be largely virtual amid pandemic MORE (D) on whether he thought 3 million deportations under the Obama administration were a good idea.

Gillibrand says the first thing she'll do as president is "Clorox the Oval Office"

Sen. Kirsten Gillibrand Kirsten GillibrandSunday shows preview: Justice Ginsburg dies, sparking partisan battle over vacancy before election Suburban moms are going to decide the 2020 election Jon Stewart urges Congress to help veterans exposed to burn pits MORE (D-N.Y.) revealed that the first action she would take as president would be to clean the Oval Office after President Trump Donald John TrumpSteele Dossier sub-source was subject of FBI counterintelligence probe Pelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Trump 'no longer angry' at Romney because of Supreme Court stance MORE left.

"The first thing I'm going to do as president is I am going to Clorox the Oval Office," Gillibrand said on stage at the Democratic presidential primary debate in Detroit.

The remark quickly sparked reaction on social media, generating a series of memes and GIFs.

However, Gillibrand came out on the losing end of an exchange with Biden when she questioned his commitment to women's rights issues in the past.

“What did you mean when you said when a woman works outside the home, it’s resulting in ‘the deterioration of family,’” Gillibrand said. “These are quotes. It was the title of the op-ed and that just causes concern for me because we know America’s women are working.”

Biden quickly responded, noting that Gillibrand had praised his record in the past

“I don’t know what’s happened except that you’re now running for president,” Biden said to applause.

Booker says 'shithole' on live TV

Booker repeated a profanity reportedly uttered by President Trump when referring to Haiti, El Salvador and some African countries.

“This really irks me, because I heard the vice president say that if you’ve got a Ph.D. you can come right into this country, well that’s playing into what the Republicans want, to pit some immigrants against other immigrants, some are from shithole countries, and some are from worthy countries,” Booker said in a jab at Biden.

The comment referred to widespread reports noting Trump had used the profanity to describe some countries when discussing immigration policy.

De Blasio takes heat over Eric Garner case

A number of the candidates piled onto the New York City mayor, taking aim specifically for not firing Officer Daniel Pantaleo for the death of Eric Garner.

Former Housing and Urban Development Secretary Julián Castro and Gillibrand, who have struggled to break out from the crowded field, went on the offensive over Pantaleo.

“He knew what he was doing. He was killing Eric Garner and he has not been brought to justice,” Castro said.

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“He should be fired now,” Gillibrand said. “If I were the mayor, I would fire him.”

De Blasio responded by placing blame on the Justice Department, which ultimately decided against bringing federal civil rights charges against Pantaleo.

De Blasio's opening speech was also interrupted by protesters shouting "fire Pantaleo," further drawing attention to the issue.

Gabbard hits Harris over prosecutor record

Rep. Tulsi Gabbard Tulsi GabbardRepublicans call on DOJ to investigate Netflix over 'Cuties' film Hispanic Caucus campaign arm endorses slate of non-Hispanic candidates Gabbard says she 'was not invited to participate in any way' in Democratic convention MORE (D-Hawaii) sought to put a spotlight on Harris's record as prosecutor, telling her to apologize to people who have "suffered under her reign."

“When you were in a position to impact these people’s lives you did not and worse yet in the case of those on death row, innocent people, you actually blocked evidence that would have freed them, until you were forced to do that, and the people who suffered under your reign as prosecutor, you owe them an apology,” Gabbard said during the contentious exchange.

Harris hit back at Gabbard, saying it's easy to give speeches criticizing opponents, but as attorney general of California, she dealt with real-world problems.

“I did the work of significantly changing the criminal justice system and I’m proud of that work, to not just give fancy speeches or be in a legislative body and give speeches on the floor but actually doing the work,” Harris said.