Norristown, Pennsylvania (CNN) Bill Cosby lowered his head, put his hand over his face and shook his head on Tuesday as a former Temple employee said he drugged and assaulted her in 2004, her testimony a dramatic moment 13 years in the making that forms the core of his assault trial.

Andrea Constand spoke clearly and firmly in her testimony, which followed much of the allegations in a criminal complaint against the 79-year-old comedic legend.

Constand, who once was the director of operations for the women's basketball team at Temple University, Cosby's alma mater, testified she visited Cosby at his home one evening in January 2004 to discuss her career plans.

At one point, he left and came back with three blue pills in his hand, and said they would help her relax, she testified.

"Put them down. They're your friends, they'll take the edge off," Cosby told her, she said. "I said, 'I trust you.' I took the pills and I swallowed the pills down."

About 20 to 30 minutes later, her words were slurring and she became weak, so Cosby moved her to a couch, she said. She began "panicking" because she thought she was having a bad reaction to the pills, but she was unable to do anything.

She continued: "I have no recollection until at some point later I was jolted conscious, I was jolted awake, and I felt Mr. Cosby's hand groping my breasts. I also felt his hand inside my vagina moving in and out. And I felt him take my hand and place it on his penis and move it back and forth."

Cosby, who has pleaded not guilty to three charges of aggravated indecent assault in the case, repeatedly shook his head as Constand spoke. She testified she wanted him to stop but was "frozen."

In the morning, she got up and still felt disoriented.

"I felt really humiliated and I was really confused," she said, wiping tears from her eyes. "I just wanted to go home."

She visited him at his home at a later point to confront him about what pills he had given her on the night of the assault.

"Mr. Cosby looked at me and said 'I thought you had an orgasm? Did you?'" Constand testified. He was "evasive" and did not answer her question, she testified, so she left.

Constand said she met Cosby in 2002 at Temple, where he was a trustee. They became friends, she said, and he invited her to several dinners at his home.

He twice attempted to touch her, she said, before January 2004. Once he put his hand in a "suggestive" way on her thigh, and she moved away. At another dinner, he moved close to her and attempted to pull down the zipper to her pants, she testified. She leaned forward to stop him and told him, "I'm not here for that."

Still, they continued their friendship. "I trusted him. I wasn't scared of him in any way," she said.

Defense asks about phone calls

On cross-examination, defense attorney Angela Agrusa said Constand had called Cosby 72 times after the alleged assault, to which Constand replied, "I don't know exactly, but yes." On Monday, during opening statements, Brian McMonagle, another Cosby attorney, said phone records showed that while Constand and Cosby spoke on the phone 72 times after the day in question, Constand initiated 53 of those calls.

She also called several personal injury lawyers before speaking to police. Constand said she phoned attorneys because she was not familiar with the law.

Agrusa also brought up Constand's initial statement to police in Canada, in which she said she had not been alone with Cosby before the assault.

However, she testified earlier Tuesday that she had been alone with him several times, including in his room at the Foxwoods Resort Casino in Mashantucket, Connecticut.

"I was mistaken," Constand said. "It was a lot of confusion putting a lot of dates together."

Constand's cross-examination will resume Wednesday morning.

2nd accuser's mother testifies

The mother of another woman who has accused Cosby of assault earlier recalled how her daughter called her crying in 1996 to tell her he had drugged and assaulted her, then tried to have her fired from the talent agency that represented him.

Patrice Sewell took the stand to corroborate daughter Kelly Johnson's allegation that she called her mother after Cosby gave her an incapacitating pill and took advantage of her at his hotel in the Bel-Air neighborhood of Los Angeles. Sewell also recounted a call in which Johnson told her Cosby was pressuring Tom Illius, his now-deceased agent at the William Morris agency, to terminate her.

"She called me at work. She was nearly hysterical. She was crying. She was telling me, 'Mommy something's going on. I don't know what's going on, but they're telling lies about me,' " Johnson said, according to Sewell.

Tuesday was the second day of Cosby's trial on charges that he drugged and assaulted Constand at his home in 2004.

Cosby, 79, has been publicly accused of assault by dozens of women, but the charges in this trial deal solely with accusations from Constand. Johnson was allowed to testify as prosecutors seek to establish the alleged assault was part of a pattern.

The jury also heard from Dave Mason, a Canadian detective, who said Constand reported to him in January 2005 that Cosby had given her pills before assaulting her. Constand could not provide an answer when asked if Cosby had engaged in intercourse with her, Mason said.

Father's advice

Photos: Who are Cosby's accusers? More than 50 women have spoken out to various media outlets about allegations of sexual misconduct by Bill Cosby. Here are 25, in chronological order, who have spoken with CNN, spoken on camera about their allegations or been the subject of responses from Cosby's attorneys. Read more on the allegations and Cosby's denials. Hide Caption 1 of 26 Photos: Who are Cosby's accusers? In January 2004, Andrea Constand, then a 31-year-old staffer for the women's basketball team at Temple University -- Cosby's alma mater -- was at the comedian's Cheltenham, Pennsylvania, home when Cosby provided her medication that made her dizzy, she alleged the next year. She later woke up to find her bra undone and her clothes in disarray, she further alleged to police in her home province of Ontario, Canada, in January 2005. She was the first person to publicly allege sexual assault by Cosby. The comedian settled a civil suit with Constand that alleged 13 Jane Does had similar stories of sexual abuse. On December 30, 2015, Cosby was charged with sexual assault in relation to the 2004 accusation, Costand's attorney Dolores Troiani confirmed to CNN. That ended in a mistrial after the jury deadlocked in June 2017, but prosecutors immediately announced they would retry the case. Hide Caption 2 of 26 Photos: Who are Cosby's accusers? Janice Dickinson alleged she and Cosby had dinner in Lake Tahoe, Nevada, in 1982 and he gave her a glass of red wine and a pill she believed was for menstrual cramps. "The last thing I remember was Bill Cosby in a patchwork robe, dropping his robe and getting on top of me. And I remember a lot of pain," she told "Entertainment Tonight." Cosby's attorney said in a statement that Dickinson's allegation was a "fabricated lie" that contradicted what she wrote in her autobiography and what she said during a 2002 New York Observer interview. Hide Caption 3 of 26 Photos: Who are Cosby's accusers? Heidi Thomas says she met Cosby in 1984 and visited him at a house outside of Reno, Nevada, for "coaching." At the time, she was a 24-year-old aspiring actress and model known as Heidi Johnson. Thomas says Cosby offered her a glass of Chablis, and she later woke up with Cosby next to her in bed, naked, and "forcing himself in my mouth." A representative of Cosby did not immediately respond to a request for comment on Thomas' allegation. Hide Caption 4 of 26 Photos: Who are Cosby's accusers? Cindra Ladd, longtime wife of Oscar-winning film producer Alan Ladd Jr., alleges Bill Cosby sexually assaulted her in 1969 when she was single and 21. Cosby's representatives did not respond to CNN's repeated requests for comment. Hide Caption 5 of 26 Photos: Who are Cosby's accusers? The now-wife of "The Incredible Hulk" star Lou Ferrigno, Carla Ferrigno, told CNN that Cosby forcibly kissed her at his home in 1967. Carla Ferrigno said she told her husband, whom she married in 1980, about the incident about five years ago and he advised her to stay silent. Hide Caption 6 of 26 Photos: Who are Cosby's accusers? Kristina Ruehli was a secretary for a talent agency in 1965 that had Cosby as a client. She said she was invited to a party to celebrate a taping of "Hollywood Palace." Ruehli said she and an actress were the only attendees at the party. She said she became unconscious after consuming drinks and later woke up to find Cosby attempting to force her mouth onto his pubic area. She said she pulled away to vomit and drove herself home. It was the last time she would see Cosby, she told CNN. Hide Caption 7 of 26 Photos: Who are Cosby's accusers? Linda Brown was a 21-year-old model in 1969 when, she alleges, Cosby drugged and sexually assaulted her in Canada near her hometown. She says she was introduced to the comedian by her then-manager, had dinner with Cosby and was later served a soft drink by Cosby at an apartment. "I took a sip and blacked out," Brown said at a press conference with her attorney in February. "When I awakened, I was naked in the bed beside him." Hide Caption 8 of 26 Photos: Who are Cosby's accusers? Joan Tarshis was a 19-year-old actress in 1969 when, she said, she met Cosby in Los Angeles. The two became friendly. One night after taping his sitcom, he invited her back to his bungalow and fixed her a "redeye" (a Bloody Mary topped with beer), she alleged. "The next thing I remember was coming to on his couch while being undressed," she told Hollywood Elsewhere. "I was sickened by what was happening to me and shocked that this man I had idolized was now raping me. Of course I told no one." It was the first of two similar incidents, said Tarshis, who is now a journalist and publicist. Hide Caption 9 of 26 Photos: Who are Cosby's accusers? Linda Joy Traitz said Cosby offered her a ride home while she was working as a waitress at a restaurant in Los Angeles that he co-owned in 1969. On the way, they detoured to the beach. They parked and he offered her drugs "to relax," she alleged. After refusing "he kept offering me the pills," she alleged, and it made her feel uncomfortable. She claimed he then groped her chest, pushing her down in the seat and toward the door, and tried to lie on top of her. She got out of the car and ran, she said. She added that she was "absolutely not" raped. He tried to calm her, she said, then drove her home in silence. Traitz has a criminal record in Florida and spent time in prison on a conviction for drug trafficking, according to state records. Cosby's lawyer passed on her lengthy rap sheet. Traitz spoke openly about her record to CNN. Hide Caption 10 of 26 Photos: Who are Cosby's accusers? Playboy bunny Victoria Valentino said her friend Francesca Emerson first introduced her to Cosby hoping to help her get work on his show "I Spy" in the late '60s. Valentino said after an interview in his trailer, Cosby invited her and a different friend to dinner, where they drank red wine and Cosby offered her pills to "cheer up," she said. She said she felt "stoned," slurring her words. They then went with him to what she described as a "ballers pad," an office-like space in an apartment building, with two loveseats and no working phone. Valentino said she was feeling "totally out of it" when she saw Cosby attempting to advance on her passed-out friend. She said she began reaching out to Cosby to pull him off her friend when he pushed her down, first pushing himself near her mouth, before turning her around and raping her. Hide Caption 11 of 26 Photos: Who are Cosby's accusers? Famed model Beverly Johnson alleged that Bill Cosby drugged her in the 1980s at his Manhattan brownstone, where she'd gone to rehearse lines. During the meeting, Johnson said, Cosby was "very insistent" she drink a cup of cappuccino he had made for her. "After that second sip, I knew I had been drugged," she alleged. "It was very powerful, it came on very quickly." Johnson said she then confronted and cursed at the comedian, claiming, "I wanted him to know he had drugged me." She alleged that Cosby got angry, grabbed her, took her outside and flagged down a taxi for her. Cosby's attorney didn't immediately return a CNN call for comment on Johnson's allegation, which she first made in a Vanity Fair article. Hide Caption 12 of 26 Photos: Who are Cosby's accusers? In 1970, Tamara Green was an aspiring model in her early 20s. She alleged an incident occurred during a working lunch with Cosby and others. Green told Matt Lauer of the "Today" show that at the lunch, she was suffering from the flu and Cosby "produced two capsules." She said they made her feel "great" at first, but then left her "almost literally face down on the table of this restaurant." Cosby took her to her apartment and started "groping me and kissing me and touching me and handling me and you know, taking off my clothes," Green said. Green further detailed her allegations in a defamation lawsuit against Cosby filed in December. Hide Caption 13 of 26 Photos: Who are Cosby's accusers? Judy Huth has filed a lawsuit in Los Angeles Superior Court claiming sexual battery and infliction of emotional distress during an incident at the Playboy Mansion, according to court documents. The alleged sexual assault took place in 1974 when Huth was 15 years old. According to court documents, Huth and a 16-year-old friend met with Cosby and eventually went to the Playboy Mansion with him. "He then proceeded to sexually molest her by attempting to put his hand down her pants and then taking her hand in his hand and performing a sex act on himself without her consent," according to the documents. Cosby's lawyer said Huth's claims are "absolutely false" and he accused her of engaging in extortion after Cosby rejected her "outrageous demand for money in order not to make her allegations public." Hide Caption 14 of 26 Photos: Who are Cosby's accusers? P.J. Masten was a Playboy bunny in her 20s and met Cosby while working as a server at one of Playboy's establishments. He asked her to lunch one afternoon in Chicago, then later called to invite her to dinner, she told CNN. Before the dinner, attended by four other men at the Whitehall Hotel, Masten said, Cosby poured her a drink. "And the next thing I know, it was 4 o'clock in the morning," Masten said. "I woke up in a bed naked, bruised. He was lying next to me, and I slithered out of the bed, my clothes all over the floor. ... I got myself together, I went downstairs, I got in a cab and I went home." Masten recalled "hurting really bad." As to why, she alleged: "There were bruise marks all over me. I knew I was raped by him." Hide Caption 15 of 26 Photos: Who are Cosby's accusers? In a statement released through lawyer Gloria Allred's office, Helen Hayes alleged that Cosby followed her and two friends "around all day" at a summer 1973 celebrity tennis tournament in Pebble Beach, California, hosted by actor Clint Eastwood. Hayes claimed she and her friends tried to avoid Cosby, but he caught up with them in a restaurant, "approached me from behind and reached over my shoulder and grabbed my right breast." "I was stunned and angry, because he had no right to do that and I did not know why he would behave that way," Hayes said. "His behavior was like that of a predator." Hide Caption 16 of 26 Photos: Who are Cosby's accusers? Louisa Moritz, seen here in a 1971 episode of "Love, American Style," told TMZ she was in the green room of the "The Tonight Show" at NBC in New York when Cosby paid her a visit. He offered to turn her into a "major star through his direction." Then he forced himself on her, she alleged. Hide Caption 17 of 26 Photos: Who are Cosby's accusers? Donna Motsinger, 73, one of the Jane Does in the civil suit with Constand, said she met Cosby while working in a restaurant in Sausalito, California. According to Motsinger, Cosby invited her to join him for his show and she accepted. On the way, they stopped for gas and had a drink. After becoming ill, Motsinger said Cosby gave her what she thought was an aspirin. "After that there was some conversation and laughing and stuff, but then the next thing I remember ... he's next to me, he's got his hands on me and I look up I see the lights of the city. I could see it clear as a bell in my mind right now, the lights of the city coming back and it was all blurry, kind of the lights, and I passed out again," she said. Hide Caption 18 of 26 Photos: Who are Cosby's accusers? Florida nurse Therese Serignese, 57, told ABC's "20/20" that she was a 19-year-old model visiting Las Vegas when Cosby handed her pills in a private dressing room after a performance. "Take these," Cosby told her, according to Serignese. After consuming the pills, she remembered "feeling drugged, and I was kind of leaning forward, and he was behind me having sex with me. And I -- I remember it because it was not good." Hide Caption 19 of 26 Photos: Who are Cosby's accusers? Jewel Allison was a model and aspiring actress in her late 20s when she met Cosby in the late 1980s. She said he offered to help her, inviting her to his home. When she arrived, no one else was there besides Cosby, Allison said. At one point, after taking a few sips of wine, she began to feel "out of it." "I realized that something sexual was going on, but I was unable to stop it," Allison told CNN. Hide Caption 20 of 26 Photos: Who are Cosby's accusers? Barbara Bowman was a 17-year-old model and actress who met Cosby in Denver in 1985. Bowman told Newsweek that Cosby visited her numerous times, giving her acting lessons and "flying me around to major cities to events." After she turned 18, Cosby "assaulted (me) a number of times," she said. In an incident in New York, Bowman "had one glass of wine and then I blacked out. I woke up throwing up in the toilet. ... I was wearing a white T-shirt that wasn't mine, and he was in a white robe." Hide Caption 21 of 26 Photos: Who are Cosby's accusers? Lise-Lotte Lublin was a 23-year-old model in 1989 when, she alleges, Cosby gave her two shots of alcohol that caused her to black out in the Elvis suite of the Hilton Hotel in Las Vegas. Her next memory was waking up at home, unable to remember what happened in the interim, she says. Hide Caption 22 of 26 Photos: Who are Cosby's accusers? Identifying herself only by a first name during a news conference with lawyer Gloria Allred, Chelan said she was a 17-year-old aspiring model who worked at the Las Vegas Hilton when her father's wife sent pictures of her to Cosby. She said Cosby arranged to meet her at the Vegas Hilton "to introduce me to someone from the Ford modeling agency." During that meeting, she said, Cosby gave her "a blue pill, which he said was an antihistamine, with a double shot of Amaretto." She alleged that Cosby lay down next to her on the bed and began touching her sexually and grunting. Hide Caption 23 of 26 Photos: Who are Cosby's accusers? Helen Gumpel, a model and actress known as Helen Selby professionally, appeared in a bit part in a late-1980s "Cosby Show" episode. A short time later, her agent got a call that Cosby wanted to meet with her. In a statement, Gumpel said that, after Cosby hugged and kissed her in front of onlookers at a New York studio, she was asked back to his dressing room. There, she found Cosby "wearing a loosely tied robe" and then -- with the robe still on -- he put "his crotch area in my face," Gumpel alleged. The comedian touched her shoulders then tried repeatedly to get Gumpel to have a drink he'd made, she said. After her refusals, Gumpel said, "Cosby turned his back to me and walked to the door. Cosby looked at me and his face clouded up, as if he was frustrated and angry, and he told me to leave." Hide Caption 24 of 26 Photos: Who are Cosby's accusers? Beth Ferrier told media outlets in 2005 that she met Cosby in Denver in the mid-'80s. He mentored her for a time, but one night, she said, he gave her a drugged cappuccino. "I woke up in my car in the parking lot with my clothes all a mess," she said. "I wondered, I still wonder, 'What did he do with me? Why was my bra unhooked?'" The two later conducted an "on-and-off consensual affair" that lasted several years, she alleged to People magazine. "He kept luring me in," Ferrier told the magazine. "I felt like I couldn't say no." At the time, Cosby's publicist told People he had no comment. Hide Caption 25 of 26 Photos: Who are Cosby's accusers? Chloe Goins told the Los Angeles Police Department on January 14 that Cosby sexually assaulted her in 2008 during a party at the Playboy Mansion, when she was 18. Spencer Kuvin, Goins' attorney, said his client may be the first accuser to have a case that falls within the statute of limitations for bringing criminal charges. Cobsy's lawyer, Martin Singer, denied the accusation and said the comedian was not in California on August 8, 2008, the night of the "Midsummer Night's Party." Hide Caption 26 of 26

Johnson told jurors through tears on Monday that Cosby used his fame and influence to pressure her to take a pill that made her feel "underwater" and unable to resist his advances. Cosby then engaged in sexual activity with her when she could not consent or resist, she said.

On Tuesday, her mother said Johnson's father, a retired Los Angeles police detective, instructed his daughter at the time not to call the police because he "didn't want her to be humiliated and feel shame and embarrassment, as he had seen others who went to the police at that time. He didn't want that to happen to her."

Jurors also heard from Joseph Miller, an attorney present at Johnson's deposition during her 1996 workers' compensation claim against William Morris.

Reason for termination argued

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The tack of the Cosby legal team was apparent in its questioning of Sewell, Johnson's mother, and in its Monday cross-examination of Johnson.

Johnson, defense lawyers said, was dismissed from the agency for other reasons, noting that the woman's complaints in her workers' compensation claim addressed verbal abuse from Illius, not sexual advances from Cosby. (Johnson has said she wanted to complain about Cosby but couldn't get the words out.)

McMonagle, the defense attorney, on Monday questioned why Johnson waited 19 years to come forward with her allegations and didn't speak to police until 2016. He further alleged that Johnson had a romantic encounter with Cosby in 1990 but rebuffed his advances during a 1996 visit to his home, which Cosby respected.

When William Morris sought to fire her for violating its policy on dating clients, Johnson filed a workers' compensation lawsuit, alleging Cosby had harassed her, McMonagle said.

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"What she did was eerily similar to Mrs. Constand," McMonagle said, accusing both women of changing their stories repeatedly. "You will never see Mr. Cosby under oath running from anything."

Mason, the Canadian detective, testified Tuesday that Constand told him in January 2005, about a year after the alleged assault, that she hadn't reported it sooner because she was embarrassed and hoped to pursue a career in broadcasting or journalism.

'He said, she said' case?

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On Monday, McMonagle pointed out inconsistencies in Johnson's story, which he used to argue that the incident did not occur.

Legal experts have said the trial will hinge on the "he said, she said" arguments so common to sexual offense cases. There is little forensic evidence against Cosby.

In opening statements, prosecutors argued that Cosby gained the trust of Constand, more than 30 years his junior, by offering to mentor her.

He betrayed that trust when he pushed her to take drugs that incapacitated her and then took advantage of her sexually, Assistant District Attorney Kristen Feden said.

"This is a case about a man, this man," Feden said, pointing to Cosby, "who used his power and his fame and his previously practiced method of placing a young trusting woman in an incapacitated state so that he could sexually pleasure himself so that she couldn't say no."

Defense: Sex was consensual

McMonagle said in opening statements that their sexual activity was consensual and that Constand had repeatedly changed her story while talking to law enforcement.

Constand told police about the incident in 2005, a year after it occurred. At the time, the district attorney declined to press charges, citing insufficient evidence.

Constand sued in civil court, and Cosby provided a sworn deposition in which he admitted to sexual activity with Constand but said the encounter was consensual. The drugs he gave Constand were over-the-counter Benadryl, he testified.

Cosby also said he had obtained Quaaludes to give them to women with whom he wanted to have sex. The civil suit was settled in 2006, and the deposition was sealed from public eyes until 2015.

Based on that deposition, Montgomery County District Attorney Kevin Steele filed charges against Cosby in December 2015.

Cosby has said he does not plan to testify in the trial, so the deposition will serve to tell Cosby's side of the story.

An American favorite

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Cosby starred in "Fat Albert and the Cosby Kids," "I Spy" and "The Cosby Show." Through the latter he turned the lives of an upper-middle-class African-American family into a groundbreaking TV sitcom.

His sweater-wearing portrayal of Dr. Cliff Huxtable made him a household name and one of the most beloved comedians in the world. In later years, Cosby became somewhat of a public moralizer, speaking out against what he saw as the failings of the African-American community in raising children.

Cosby is facing a jury of seven men and five women. Two jurors are black. The jurors, who were selected in Allegheny County in an effort to ensure a fair trial, will be sequestered in the criminal trial for about two weeks, the lawyers in the case have predicted.