But after two weeks of relying on a largely one-dimensional offense, the Titans may diversify now that they have gotten past New England and Baltimore, which had two of the three most suffocating secondaries in the N.F.L.

Quarterback Ryan Tannehill has shown a keen ability to take advantage of any opportunity afforded him, and the Chiefs, who are missing their standout rookie safety, Juan Thornhill (A.C.L. tear), and do not yet know the status of Pro Bowl defensive tackle Chris Jones (calf), may just give him a few — provided he keeps the ball as far away from safety Tyrann Mathieu as possible.

Tennessee used a blend of Henry and Tannehill in Week 10 to beat the Chiefs, 35-32, in Nashville. But Mahomes, in his first game back from a knee injury, passed for 446 yards and three touchdowns in that game. He could be capable of even more against a Titans defense that seemed to wear down as the season chugged along, finishing in the middle of the pack in most rankings. While Tennessee creates some chaos with turnovers, it is also fairly soft against the pass. That should be an extreme liability against Mahomes, who has his choice of Tyreek Hill, Sammy Watkins and Travis Kelce on every play.

For Tennessee to pull off its third consecutive upset, it will need to get a few huge plays from Tannehill, grind up the clock with Henry and hope the defense can take advantage of a mistake or two from Mahomes. Each of those things is possible, but getting all three is not very likely. A narrow defeat is a better bet. Pick: Titans +7