Terraria: Debuffs

Immunity and Vulnerabilities of Bosses

Some debuffs can be very helpful when fighting bosses as they may deal damage over time or weaken them. Finding which debuffs will or won't work on them can be time consuming, just by browsing the wiki, as info is all spread out. I'm going to help with that with this list - each boss is listed, along with which debuffs they are immune to, and those they are vulnerable to. There are many more debuffs in Terraria, but some are inflicted only by monsters. The ones I've chosen to list are those that you can get from a potion, arrow, weapon, flask, or spell.

Here are the six debuffs I'm listing for the bosses, and the most common examples of where they come from. Some of these are only useful Pre-Hardmode because of the amount of life bosses have later in a game.

Poisoned - lose 2 life per second. Comes from Blade of Grass, Thorn Chakram, Poison Staff, and Flask of Poison

- lose 2 life per second. Comes from Blade of Grass, Thorn Chakram, Poison Staff, and Flask of Poison On Fire! - lose 4 life per second. Comes from Inferno Potion (Aura), Fiery/Molten Weapons, Flower of Fire, Flamarang, Sunfury, Flamethrowers, Fire Gauntlet, Magma Stone, Flask of Fire

- lose 4 life per second. Comes from Inferno Potion (Aura), Fiery/Molten Weapons, Flower of Fire, Flamarang, Sunfury, Flamethrowers, Fire Gauntlet, Magma Stone, Flask of Fire Frostburn - Most bosses are vulnerable. Lose 6 life per second. Comes from Frostburn Arrows, Flower of Frost, Frost Armor, and Amarok (Yoyo)

- Most bosses are vulnerable. Lose 6 life per second. Comes from Frostburn Arrows, Flower of Frost, Frost Armor, and Amarok (Yoyo) Venom - lose 6 life per second. Comes from Venom Bullets/Arrows, Venom Staff, Spider Staffs, Flask of Venom

- lose 6 life per second. Comes from Venom Bullets/Arrows, Venom Staff, Spider Staffs, Flask of Venom Cursed Inferno (Corruption) - stops health regen and lose 4 life per second. Comes from Flask of Cursed Flames, Cursed Arrow/Bullet/Dart, Cursed Flames spell, Spectral Arrow (Con/Mobile), Clinger Staff

- stops health regen and lose 4 life per second. Comes from Flask of Cursed Flames, Cursed Arrow/Bullet/Dart, Cursed Flames spell, Spectral Arrow (Con/Mobile), Clinger Staff Ichor (Crimson) - lowers defense by 20. Comes from Flask of Ichor, Bladetongue, Ichor Bullet/Arrow/Dart, and Golden Shower Spell

Bosses that are explicitly immune to all debuffs below should not be affected by Shadowflame, Daybroken, nor the Stardust Cell Staff's Debuff.

Note that for bosses that spawn minions, many of them are vulnerable to these debuffs and they can help you to clear them faster.

Use Control+F to find the boss you seek. I've listed Hardmode Event Bosses toward the bottom.

Pre-Hardmode Bosses Boss Immune to: Vulnerable to: King Slime Venom Poisoned, On Fire!, Frostburn, Cursed Inferno, Ichor Eye of Cthulhu None Poisoned, On Fire!, Frostburn, Venom, Cursed Inferno, Ichor Eater of Worlds Poisoned, On Fire!, Venom, Cursed Inferno Frostburn, Ichor Brain of Cthulhu None Poisoned, On Fire!, Frostburn, Venom, Cursed Inferno, Ichor Queen Bee None Poisoned, On Fire!, Frostburn, Venom, Cursed Inferno, Ichor Skeletron Poisoned, On Fire!, Venom, Cursed Inferno, Frostburn, Ichor Wall of Flesh Poisoned, On Fire!, Venom, Cursed Inferno, Frostburn, Ichor

Hard Mode Bosses Boss Immune to: Vulnerable to: The Destroyer Boss and Minions Immune to All Debuffs None The Twins None Poisoned, On Fire!, Frostburn, Venom, Cursed Inferno, Ichor Skeletron Prime Poisoned, On Fire!, Venom, Cursed Inferno (Head only. Other parts vulnerable) Frostburn, Ichor Plantera Poisoned, Venom On Fire!, Frostburn, Cursed Inferno, Ichor Golem Poisoned, On Fire!, Venom Frostburn, Cursed Inferno, Ichor Duke Fishron Poisoned, On Fire!, Frostburn, Venom Cursed Inferno, Ichor Lunatic Cultist Immune to All Debuffs None Moon Lord Ichor Poisoned, On Fire!, Frostburn, Venom, Cursed Inferno

Hard Mode Event Bosses Boss Immune to: Vulnerable to: Flying Dutchman (Pirate Invasion) Immune to All Debuffs None Mourning Wood (Pumpkin Moon) Immune to All Debuffs None Pumpking (Pumpkin Moon) Immune to All Debuffs None Everscream (Frost Moon) Poisoned, Venom On Fire!, Frostburn, Cursed Inferno, Ichor Santa-NK1 (Frost Moon) Poisoned, Venom On Fire!, Frostburn, Cursed Inferno, Ichor Ice Queen (Frost Moon) Poisoned, Venom On Fire!, Frostburn, Cursed Inferno, Ichor Martian Saucer (Martian Madness) Immune to All Debuffs None

Special thanks to those who work on the excellent wiki at gamepedia, without whom I could not have made this list. Testing every debuff on every boss would be incredibly tedious!

- Share your Terraria Gameplay Tips and Strategies below!

