Just when you thought all variations on the Ice Bucket Challenge had been exhausted, rapper B-Real from Cypress Hill shows up with a bucket of marijuana.

"I know we're going through a drought with water and all that stuff, so we're going to do it a little different, but I accept the challenge," B-Real, a noted marijuana advocate, says in a video posted last week to Hustla Subs, a hip-hop YouTube channel, just before a large bucket of marijuana buds is dumped over his head.

"Snoop Dogg, Willie Nelson, Woody Harrelson -- you've got 24 hours to accept," B-Real says at the end of the video, challenging three other celebrities with well-known affinities for cannabis.

We eagerly await responses from these three.

Donations inspired by the ubiquitous Ice Bucket Challenge -- in which participants pour a bucket of ice water on their heads to raise awareness of amyotrophic lateral sclerosis (ALS), a degenerative nerve disease -- have been coming in at an astounding rate since the practice went viral earlier this summer.

As of Tuesday, the ALS Association (ALSA) -- which fights the disease by funding research, supporting people with the condition and corralling federal resources -- had collected $88.5 million toward its efforts, a majority of which had been donated in the past seven days. It's a particularly stunning figure considering that the organization took in just $2.6 million in the same period last year, according to a statement released by the group.

And while B-Real is having some fun with the viral video craze, substituting marijuana for ice water, research suggests that the plant may in fact be an effective treatment for ALS. A study published earlier this year in the journal CNS Neuroscience and Therapeutics found that Sativex, a drug developed by GW Pharmaceuticals that contains both cannabidiol (a non-psychoactive compound found in marijuana) and THC (the main psychoactive ingredient in marijuana that causes the "high" sensation), may slow the progression of ALS symptoms in mice.