Trivia

They first appeared in 1940 in Fleischer Studios's Wimmin is a Myskery ("Poopeye" is replaced by "Pepeye" in this episode), however their first appearance was only in a dream sequence as Popeye's children. Their first appearance proper as his nephews occurs in the 1942 Pip-eye, Pup-eye, Poop-eye an' Peep-eye.

Popeye's Nephews are similar to the triplets Huey, Dewey and Louie from Mickey Mouse series, being that like them, both groups challenge to their respective uncles and they defeat them in some episodes of their respective series. Huey, Dewey and Louie to their uncle Donald and Popeye's Nephews to their uncle.

Popeye's Nephews are a quadruplet of identical nephews with their own names: Pipeye, Peepeye, Pupeye, & Poopeye. Despite becoming like their Uncle Popeye , they dislike spinach.