WASHINGTON, D.C. - First, comments that Stephen Moore made about women came back to haunt the Heritage Foundation columnist whom President Donald Trump is considering for an appointment on the Federal Reserve’s Board of Governors.

Now, a video of Moore trashing Cleveland and Cincinnati has incensed the top Democrat on the Senate committee that would have to sign off on his nomination: Ohio’s Sherrod Brown.

On Tuesday, Brown sent a letter to Moore that says he’s “offended and troubled” by comments Moore made at a 2014 Heartland Institute book discussion event in Chicago, where he said: “If you want to live in the Midwest, where else do you want to live besides Chicago? You don’t want to live in Cincinnati or Cleveland or these armpits of America like that. You want to live in Chicago.”

His remarks are around 46 minutes and 45 seconds into the above video.

“That view should be disqualifying for the critical role of Governor of the Federal Reserve Board,” Brown’s letter said. “You didn’t just insult Cleveland and Cincinnati – you dismissed millions of Americans who work and live in small towns and cities across the industrial heartland, and who have been looked down on and left behind by Washington and Wall Street for decades. As a public servant, your job would be to fight for these Americans – something you cannot do when you don’t know the first thing about the places where they live.”

The letter also demands that Moore apologize for and retract the statement, “on behalf of the people of Ohio, the Midwest and every community that has been looked down on and disparaged by Washington and Wall Street,” and asks why he disparaged Cleveland and Cincinnati.

“Unfortunately, it’s not just your words that make your disdain for the American people clear," wrote Brown, who clearly won’t be supporting Moore’s nomination. "You have a long history of supporting policies that have directly contributed to the challenges faced by the millions of Americans in these towns and cities. Your positions on the economy, tax cuts for the wealthy, health care, financial regulation, and farm policy show that you don’t understand the ongoing challenges these communities face and the policies that would actually help them.”

A spokesman for Ohio Republican Sen. Rob Portman said his boss will carefully review Moore’s record and qualifications if he’s nominated.

“If Stephen Moore meant that as a joke it was a bad one," Portman spokesman Kevin Smith said of Moore’s remarks.

Cleveland.com has sought comment from Moore through his office at the Heritage Foundation, and from the White House.

Past writings and comments by Moore, who formerly headed the conservative Club for Growth, are being given close scrutiny in the month since Trump told reporters he plans to nominate Moore to serve on central bank’s board. The Federal Reserve helps maintain the stability of the nation’s monetary system and regulates banks and other financial institutions.

Among other things, Moore has said that women should not be allowed to referee men’s sports unless they’re good looking, and called it a “travesty” that women “feel free” to play sports with men. Moore told CNN those comments were made in jest.

“This was a spoof," he said in an email to the network. "I have a sense of humor.