The identities of three young Americans who fled a sheltered life growing up in Ohio and California to join ISIS have been revealed in a new report.

Jaffrey Khan, 24, is believed to have fled the U.S. for Syria in 2014 along with his wife Zakia Raihan, a former class valedictorian, and her brother Rasel, who once aspired to enroll at Harvard.

The trio made their way to Raqqa, according to NBC News, where Zakia and Jaffrey had a baby daughter and began working at the main hospital serving the terrorists' so-called Caliphate.

Jaffrey Khan, 24, is believed to have become radicalized through his step-father before meeting Zakia Raihan (right) online, marrying her, and then converting her to an extreme from of Islam

Meanwhile Rasel, described by his family as a straight A student who loved to play computer games, is believed to have been killed in an airstrike, though the circumstances are unclear.

According to NBC, the trio's descent from privileged kids growing up in liberal America to die-hard jihadis began with Jaffrey, described by those who knew him as someone who 'struggled to fit in.'

Jaffrey's father told the station that his son was disruptive in school, found it hard to concentrate, was diagnosed with ADHD and proscribed a course of Ritalin to help calm him down.

Rasel Raihan, Zakia's younger brother, moved in with his sister in 2013 during a bout of depression, months before the trio left for Syria

The boy also grew up between households after his father and mother split at a young age, before both going on to remarry.

He turned to drugs, smoking pot as a teenager, and listened to hip-hop records with friends.

Disaffected with life, bored by school, and frustrated with his lack of achievement, it was not until his mother's new husband introduced him to religion that Jaffrey's life took on a purpose.

Within months he had grown a bear, began referring to Americans as 'non-believers', became angry at society and spoke of leaving the West to live in a Muslim country.

During this time he met Zakia online, herself a gifted student who aspired to become a doctor and was enrolled at Ohio State University.

During their conversations, however, Jaffrey managed to persuade her away from that life and into marrying him. She left Ohio for California to live with him, cut ties with her old friends, began wearing a headscarf and following a fundamentalist form of Islam.

Rasel, also a gifted student, was sucked into their web after pressure got to him at school.

Friends say a B grade on one report caused him to withdraw from social life, before a failed chemistry test drove him to depression and he started cutting classes.

After being placed on anti-depressant medication, Rasel is reported to have turned to his sister for comfort, before moving in with her and Jaffrey around fall 2013.

From there the trio moved quickly. In May 2014 the left their house and within two months were reported to be in Raqqa, where Zakia and Jaffrey live as husband and wife.