KABUL (Reuters) - A roadside bomb blew up a van in Afghanistan’s south on Thursday, killing 14 civilians, including women and children, and wounding several more people, officials said.

Roadside and other bombs are by far the most lethal weapons deployed by Taliban insurgents and are responsible for most of the war casualties suffered among Afghan security forces, foreign troops and civilians.

The incident occurred in the Nahr-e-Saraj district of southern Helmand province, a Taliban stronghold and one of the country’s most dangerous provinces, said provincial governor spokesman Dawood Ahmadi.

The NATO-led International Security Assistance Force (ISAF) said in a statement that Afghan and foreign troops provided medical assistance at the scene and evacuated the wounded.

Afghan President Hamid Karzai strongly condemned the attack and said that people who planted bombs on roads frequently used by civilians were “brutal and ignorant terrorists who are enemies of Islam and innocent Afghans.”

Violence is at its worst in Afghanistan since U.S.-backed Afghan troops ousted the Taliban in 2001, with record deaths on all sides of the near-decade long conflict. The number of foreign troops killed this year has passed 700.

The United Nations said this month there were 6,215 civilian casualties in conflict-related incidents in Afghanistan, including 2,412 deaths and 3,803 injuries, between January and the end of October this year.

The report said casualties rose by 20 percent in the first 10 months of the year compared to 2009, and held Taliban and other militant groups responsible for 76 percent of the deaths or injuries suffered by civilians.