1. Wittchen HU, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jönsson B, et al. The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol. 2011;21:655–79.

2. Carpenter JK, Andrews LA, Witcraft SM, Powers MB, Smits JAJ, Hofmann SG. Cognitive behavioral therapy for anxiety and related disorders: a meta-analysis of randomized placebo-controlled trials. Depress Anxiety. 2018;35:502–14.

3. Foa EB, McLean CP. The efficacy of exposure therapy for anxiety-related disorders and its underlying mechanisms: the case of OCD and PTSD. Annu Rev Clin Psychol. 2016;12:1–28.

4. Craske MG, Hermans D, Vervliet B. State-of-the-art and future directions for extinction as a translational model for fear and anxiety. Phil Trans R Soc B. 2018;373:20170025.

5. Davis M. NMDA receptors and fear extinction: implications for cognitive behavioral therapy. Dialogues Clin Neurosci. 2011;13:463–74.

6. Fanselow MS, LeDoux JE. Why we think plasticity underlying Pavlovian fear conditioning occurs in the basolateral amygdala. Neuron. 1999;23:229–32.

7. Hillman BG, Gupta SC, Stairs DJ, Buonanno A, Dravid SM. Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory. Neurobiol Learn Mem. 2011;95:404–14.

8. Santini E, Muller RU, Quirk GJ. Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory. J Neurosci. 2001;21:9009–17.

9. Davis M, Ressler K, Rothbaum BO, Richardson R. Effects of d-cycloserine on extinction: translation from preclinical to clinical work. Biol Psychiatry. 2006;60:369–75.

10. Norberg MM, Krystal JH, Tolin DF. A meta-analysis of d-cycloserine and the facilitation of fear extinction and exposure therapy. Biol Psychiatry. 2008;63:1118–26.

11. Fitzgerald PJ, Seemann JR, Maren S. Can fear extinction be enhanced? A review of pharmacological and behavioral findings. Brain Res Bull. 2014;105:46–60.

12. Ori R, Amos T, Bergman H, Soares-Weiser K, Ipser JC, Stein DJ. Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders. Cochrane Database Syst Rev. 2015;5:CD007803.

13. Mataix-Cols D, Fernández de la Cruz L, Monzani B, Rosenfield D, Andersson E, Pérez-Vigil A, et al. D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders. JAMA Psychiatry. 2017;74:501–10.

14. Rodrigues H, Figueira I, Lopes A, Gonçalves R, Mendlowicz MV, Coutinho ESF, et al. Does D-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis. PLoS ONE. 2014;9:e93519.

15. Vervliet B, Craske MG, Hermans D. Fear extinction and relapse: state of the art. Annu Rev Clin Psychol. 2013;9:215–48.

16. Dunsmoor JE, Niv Y, Daw N, Phelps EA. Rethinking extinction. Neuron. 2015;88:47–63.

17. Bouton ME. Context, ambiguity, and unlearning: sources of relapse after behavioral extinction. Biol Psychiatry. 2002;52:976–86.

18. Sehlmeyer C, Schöning S, Zwitserlood P, Pfleiderer B, Kircher T, Arolt V, et al. Human fear conditioning and extinction in neuroimaging: a systematic review. PLoS ONE. 2009;4:e5865.

19. Fullana MA, Harrison BJ, Soriano-Mas C, Vervliet B, Cardoner N, Avila-Parcet A, et al. Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies. Mol Psychiatry. 2016;21:500–8.

20. Fullana MA, Albajes-Eizagirre A, Soriano-Mas C, Vervliet B, Cardoner N, Benet O, et al. Fear extinction in the human brain: a meta-analysis of fMRI studies in healthy participants. Neurosci Biobehav Rev. 2018;88:16–25.

21. Milad MR, Quinn BT, Pitman RK, Orr SP, Fischl B, Rauch SL. Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory. Proc Natl Acad Sci USA. 2005;102:10706–11.

22. Milad MR, Wright CI, Orr SP, Pitman RK, Quirk GJ, Rauch SL. Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert. Biol Psychiatry. 2007;62:446–54.

23. Kalisch R, Korenfeld E, Stephan KE, Weiskopf N, Seymour B, Dolan R. Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. J Neurosci. 2006;26:9503–11.

24. Lonsdorf TB, Haaker J, Kalisch R. Long-term expression of human contextual fear and extinction memories involves amygdala, hippocampus and ventromedial prefrontal cortex: a reinstatement study in two independent samples. Soc Cogn Affect Neurosci. 2014;9:1973–83.

25. Scharfenort R, Menz M, Lonsdorf TB. Adversity-induced relapse of fear: neural mechanisms and implications for relapse prevention from a study on experimentally induced return-of-fear following fear conditioning and extinction. Transl Psychiatry. 2016;6:e858–8.

26. Kalisch R, Holt B, Petrovic P, De Martino B, Klöppel S, Büchel C, et al. The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans. Cereb Cortex. 2009;19:187–96.

27. Klumpers F, Denys D, Kenemans JL, Grillon C, van der Aart J, Baas JMP. Testing the effects of Delta9-THC and D-cycloserine on extinction of conditioned fear in humans. J Psychopharmacol. 2012;26:471–8.

28. Guastella AJ, Lovibond PF, Dadds MR, Mitchell P, Richardson R. A randomized controlled trial of the effect of d-cycloserine on extinction and fear conditioning in humans. Behav Res Ther. 2007;45:663–72.

29. Kuriyama K, Honma M, Soshi T, Fujii T, Kim Y. Effect of d-cycloserine and valproic acid on the extinction of reinstated fear-conditioned responses and habituation of fear conditioning in healthy humans: a randomized controlled trial. Psychopharmacol (Berl). 2011;218:589–97.

30. Brom M, Laan E, Everaerd W, Spinhoven P, Trimbos B, Both SD. Cycloserine reduces context specificity of sexual extinction learning. Neurobiol Learn Mem. 2015;125:202–10.

31. Ebrahimi C, Koch SP, Friedel E, Crespo I, Fydrich T, Ströhle A, et al. Combining d-cycloserine with appetitive extinction learning modulates amygdala activity during recall. Neurobiol Learn Mem. 2017;142:209–17.

32. Wittchen HU, Pfister H. DIA-X interview. Instruction manual for the DIA-X interview. Frankfurt: Zwets and Zeitlinger; 1997.

33. Ishihara S. Tests for colour-blindness. Tokyo: Hongo Harukicho Handaya; 1917.

34. Reiss S, Peterson RA, Gursky DM, McNally RJ. Anxiety sensitivity, anxiety frequency and the predictions of fearfulness. Behav Res Ther. 1986;24:1–8.

35. Schwarzmeier H, Kleint NI, Wittchen HU, Ströhle A, Hamm AO, Lueken U. Characterizing the nature of emotional-associative learning deficits in panic disorder: an fMRI study on fear conditioning, extinction training and recall. Eur Neuropsychopharmacol. 2019;29:306–18.

36. Ekman P. Facial expression of emotions: new findings, new questions. Psychol Sci. 1992;3:3–38.

37. Friedman L, Glover GH, Krenz D, Magnotta V. Reducing inter-scanner variability of activation in a multicenter fMRI study: Role of smoothness equalization. Neuroimage. 2006;32:1656–68.

38. R Core Team. R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing; 2017.

39. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B. 1995;57:289–300.

40. Moerel M, De Martino F, Formisano E. An anatomical and functional topography of human auditory cortical areas. Front Neurosci. 2014;8:225.

41. LeDoux JE. Emotion circuits in the brain. Ann Rev Neurosci. 2000;23:155–84.

42. Büchel C, Dolan RJ, Armony JL, Friston KJ. Amygdala-hippocampal involvement in human aversive trace conditioning revealed through event-related functional magnetic resonance imaging. J Neurosci. 1999;19:10869–76.

43. Büchel C, Morris J, Dolan RJ, Friston KJ, Street R, Büchel C, et al. Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron. 1998;20:947–57.

44. Landkroon E, Mertens G, Sevenster D, Dibbets P, Engelhard IM. Renewal of conditioned fear responses using a film clip as the aversive unconditioned stimulus. J Behav Ther Exp Psychiatry. 2019;65:101493.

45. Norrholm SD, Vervliet B, Jovanovic T, Boshoven W, Myers KM, Davis M, et al. Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humans. Behav Neurosci. 2008;122:1016–30.

46. Haaker J, Golkar A, Hermans D, Lonsdorf TB. A review on human reinstatement studies: an overview and methodological challenges. Learn Mem. 2014;21:424–40.

47. Duits P, Cath DC, Lissek S, Hox JJ, Hamm AO, Engelhard IM, et al. Updated meta-analysis of classical fear conditioning in the anxiety disorders. Depress Anxiety. 2015;32:239–53.

48. Boucsein W, Fowles DC, Grimnes S, Ben-Shakhar G, Roth WT, Dawson ME, et al. Publication recommendations for electrodermal measurements. Psychophysiology. 2012;49:1017–34.

49. Lonsdorf TB, Menz MM, Andreatta M, Fullana MA, Golkar A, Haaker J, et al. Don’t fear ‘fear conditioning’: methodological considerations for the design and analysis of studies on human fear acquisition, extinction, and return of fear. Neurosci Biobehav Rev. 2017;77:247–85.

50. Haaker J, Lonsdorf TB, Thanellou A, Kalisch R. Multimodal assessment of long-term memory recall and reinstatement in a combined cue and context fear conditioning and extinction paradigm in humans. PLoS ONE. 2013;8:1–10.

51. Leuchs L, Schneider M, Spoormaker VI. Measuring the conditioned response: a comparison of pupillometry, skin conductance, and startle electromyography. Psychophysiology. 2019;56:e13283.

52. Pietrock C, Ebrahimi C, Katthagen TM, Koch SP, Heinz A, Rothkirch M, et al. Pupil dilation as an implicit measure of appetitive Pavlovian learning. Psychophysiology. 2019;56:e13463.

53. Åhs F, Kragel PA, Zielinski DJ, Brady R, Labar KS. Medial prefrontal pathways for the contextual regulation of extinguished fear in humans. Neuroimage. 2016;15:262–71.

54. Phelps EA, Delgado MR, Nearing KI, LeDoux JE. Extinction learning in humans: Role of the amygdala and vmPFC. Neuron. 2004;43:897–905.

55. Agren T, Engman J, Frick A, Bjorkstrand J, Larsson E-M, Furmark T, et al. Disruption of reconsolidation erases a fear memory trace in the human amygdala. Science. 2012;337:1550–2.

56. Milad MR, Quirk GJ. Fear extinction as a model for translational neuroscience: ten years of progress. Annu Rev Psychol. 2012;63:129–51.

57. Greco JA, Liberzon I. Neuroimaging of fear-associated learning. Neuropsychopharmacology. 2016;41:320–34.

58. Furini C, Myskiw J, Izquierdo I. The learning of fear extinction. Neurosci Biobehav Rev. 2014;47:670–83.

59. Ebrahimi C, Koch SP, Pietrock C, Fydrich T, Heinz A, Schlagenhauf F. Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans. Transl Psychiatry. 2019;9:148.

60. Lissek S, Glaubitz B, Uengoer M, Tegenthoff M. Hippocampal activation during extinction learning predicts occurrence of the renewal effect in extinction recall. Neuroimage. 2013;81:131–43.

61. Sierra-Mercado D, Padilla-Coreano N, Quirk GJ. Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology. 2011;36:529–38.

62. Ji J, Maren S. Electrolytic lesions of the dorsal hippocampus disrupt renewal of conditional fear after extinction. Learn Mem. 2005;12:270–6.

63. Buchel C, Morris J, Dolan RJ, Friston KJ. Brain systems mediating aversive conditioning: an event-related fMRI study. Neuron. 1998;20:947–57.

64. Milad MR, Quirk GJ, Pitman RK, Orr SP, Fischl B, Rauch SL. A role for the human dorsal anterior cingulate cortex in fear expression. Biol Psychiatry. 2007;62:1191–4.

65. Namkung H, Kim S, Sawa A, Sciences B. The insula: an underestimated brain area in clinical neuroscience, psychiatry, and neurology. Trends Neurosci. 2018;40:200–7.

66. Paulus MP, Stein MB. An insular view of anxiety. Biol Psychiatry. 2006;60:383–7.

67. Pittig A, Treanor M, LeBeau RT, Craske MG. The role of associative fear and avoidance learning in anxiety disorders: Gaps and directions for future research. Neurosci Biobehav Rev. 2018;88:117–40.

68. Loftus GR, Masson ME. Using confidence intervals in within-participant designs. Psychon Bull Rev. 1994;1:476–90.