Police in Saskatoon say new, dangerous combinations of fentanyl and other drugs are appearing in the area.

In March, police said they seized 2.7 grams of methoxyacetylfentanyl, a fentanyl-variant, mixed with heroin, fentanyl and caffeine. It's the first time the drug has been found in the city.

Police said the new drug presents an even greater risk to public safety than traditional fentanyl.

"You may think you know what you are taking, but unless it is prescribed by a doctor or dispensed by a pharmacist, it could contain a variety of potentially deadly substances," said Inspector Dale Solie in a news release.

Earlier this month, police also seized fentanyl laced with Dimethyltryptamine (DMT), a dangerous hallucinogen.

The new drug warnings have prompted the Saskatchewan Health Authority to promote its take-home Naloxone program.

Naloxone is given to people who are suffering an opioid overdose, and can buy emergency personnel enough time to transport the person to hospital.

Earlier this month, the Saskatchewan College of Pharmacy Professionals unscheduled Naloxone, making it easier for individuals and community-based organizations to distribute them.