A stretch of road in Sydney's booming south-west is set to be converted into Australia's first driverless bus route.

The new plans and animation, obtained exclusively by 9NEWS, show the hi-tech buses and transformed road from Liverpool CBD to the new Western Sydney Airport.

The 20-minute trip on the "Rapid Transit Corridor" starts at Hoxton Park Road before merging into Fifteenth Avenue.

Liverpool Mayor Wendy Waller wants the proposed driverless 19-kilometre road operating within five years to transport workers to and from the airport during construction.

It would then operate as a fast connection for travellers and employees working at both the airport and nearby Aerotropolis – an industrial and business hub.

The 20-minute trip starts on Hoxton Park Road in Liverpool. (9NEWS) (9news)

"We believe there is a great opportunity to build a significant piece of infrastructure in partnership with the private sector that will bring to life the aspiration of the 30-minute city in Sydney's south west," Cr Waller told 9News.

"It's about the future being here now," she said.

"It's not waiting for it to happen. It's happening and we want to see that technology in Liverpool and we want to see it being used for residents and also workers."

About 11,000 workers are expected to help construct the new airport, which is due to open by 2026.

But the route also winds its way through the south-west – and, once operating, will help connect residents to new jobs at the airport and Aerotropolis.

Sydney's south-west will see Australia's first driverless bus route. (9NEWS) (9news)

David Borger, Western Sydney Director of the Sydney Business Chamber, believes the driverless rapid transit system will supercharge the entire corridor.

"If you're living in Miller, it will mean it's your lifeblood to the airport. It'll connect you to a massive job engine within about ten minutes," he said.

And he believes it will lead to new residential, commercial, educational and other construction that will make Liverpool and surrounds unrecognisable within two decades.

A Rapid Bus Connection was a commitment in the new Cities Deal announced by the Federal and State Governments earlier this month.

Driverless buses have been trialled in Sydney and around the world, as a future transport solution.