A spate of fatal truck crashes has "disturbed" NSW Roads Minister Melinda Pavey after a 45 per cent increase in deaths last year.

Her comments followed three deadly collisions in two days, including one on the Newell Highway near Dubbo on Tuesday in which a B-Double truck collided with cars and another truck at a stop-go sign, killing two people.

"I'm just so concerned and disturbed about the level of accidents involving heavy vehicles in NSW at the moment," Ms Pavey told the ABC.

"We've had six heavy vehicles involved in accidents in the past 24 hours which are going to destroy lives, destroy families."