A Florida gambler went bust when two vixens spiked his drink, ripped off his $15,000 Rolex — and $1,000 for good measure.

Surveillance video from inside the Hard Rock Casino in Hollywood shows two unidentified women sidling up to the victim as he played slots in the early morning hours of Sept. 13.

One of the women, a blond woman with a tattoo on her chest, then pours an unknown substance into his drink, video shows.

Moments later, the man stands up and appears to check his surroundings as the second suspect, a woman in a leopard jumpsuit, points her finger away from the slot machines.

The man is then seen walking through a lobby with his arms around the women before the three hopped into an awaiting SUV that took them to his Dania Beach hotel, according to the Broward County Sheriff’s Office.

Once inside, the victim said he lost consciousness and awoke the following morning to find that his cash and pricey steel watch were gone.

A reward of up to $3,000 is being offered for information leading to an arrest. Deputies described the women as 35 to 45 years old.

It’s unclear what substance the women allegedly placed in the man’s drink. A message seeking comment from sheriff officials was not immediately returned Thursday.