Across the globe, travelers faced ever-greater disruptions, as countries sought to keep the virus out.

The global march of the new virus triggered a vigorous appeal Thursday from the WHO for governments to pull out “all the stops” to slow the epidemic, as it drained color from India’s spring festivities, closed Bethlehem’s Nativity Church and blocked Italians from visiting elderly relatives in nursing homes. As China, after many arduous weeks, appeared to be winning its epic, costly battle against the new virus, the fight was revving up in newly affected areas of the globe, unleashing disruptions that profoundly impacted billions of people.

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The U.N. health agency urged all countries to “push this virus back,” a call to action reinforced by figures showing about 17 times as many new infections outside China as in it. The virus has infected nearly 98,000 people and killed over 3,300. “This is not a drill. This is not the time for giving up. This is not a time for excuses. This is a time for pulling out all the stops,” WHO Director-General Tedros Adhanom Ghebreyesus said in Geneva. “Countries have been planning for scenarios like this for decades. Now is the time to act on those plans.”

As Chinese manufacturers gradually reopened their factories, anti-virus barriers went up elsewhere. In Italy, the epicenter of Europe’s outbreak, workers in latex gloves pinned “closed” notices on school gates, enforcing a 10-day shutdown of the education system. Italy’s sports-mad fans are also barred from stadiums until April 3. A government decree that took effect Thursday urged the country’s famously demonstrative citizens to stay at least 1 meter (3 feet) apart from each other, placed restrictions on visiting nursing homes and urged the elderly not to go outside unless absolutely necessary.

That directive appeared to be widely ignored, as school closures nationwide left many Italian children in the care of their grandparents. Parks in Rome overflowed with young and old, undercutting government efforts to shield older Italians from the virus that hits the elderly harder than others. Italy has the world’s oldest population after Japan. “It’s an absolute paradox!” said Mauro Benedetti, a 73-year-old retiree called upon to watch his grandson. “They tell us to stay home. How can we help our kids and grandkids at the same time?” “Grandparents are now at risk,” he said.

Italy’s death toll climbed Thursday to 148, and its confirmed cases to 3,858. Iran, which has registered 107 virus deaths, also closed schools and universities and introduced checkpoints to limit travel between major cities. Iranians were urged to reduce their use of paper money. Iranian state TV also reported that Hossein Sheikholeslam, a 68-year-old diplomat who was an adviser to Iran’s foreign minister, had died of the virus.

Amid the string of bad news, Iranian President Hassan Rouhani urged state television to offer “happier” programs to entertain those stuck at home. Brian Hook, the U.S. special representative for Iran, said the United States offered humanitarian assistance to help Iran deal with its outbreak but “the regime rejected the offer.” He said the offer would stand.

Virus fears also affected the joyful Indian celebration of Holi, in which Hindu revelers celebrate the arrival of spring with bursts of color, including bright powders smeared on faces. Prime Minister Narendra Modi and other leaders said they wouldn’t attend Holi events and the Holi Moo Festival in New Delhi was canceled.

In the United States, where 12 have died from the virus, hundreds were placed in self-quarantines due to cases in a New York suburb. A suburban Seattle school district with 22,000 students announced it would close for up to two weeks because of coronavirus concerns and Seattle’s normally clogged highways were nearly vacant for Thursday’s morning commute as large tech employers like Amazon encouraged employees to work from home. In Seattle, health officials recommended that the elderly and people with weak immune systems not attend games after an employee at the 72,000-seat football stadium tested positive for the coronavirus.

Off the coast of California, a cruise ship carrying about 3,500 people was ordered to stay put until passengers and crew could be tested because a traveler from its previous voyage died and another three were infected. A helicopter delivered test kits to the ship, which has people aboard with flu-like symptoms — lowering the kits by rope to the 951-foot (290-meter) Grand Princess Financial markets remained volatile, as investors continued to weigh the size of the epidemic’s dent on the global economy.

Outbreak fears led to a sharp U.S. stock selloff, with the Dow Jones Industrial Average falling 969 points, or 3.6 percent, nearly wiping out gains from a day earlier. Analysts said more yo-yo moves on global markets are likely while new infections accelerate. The OPEC oil cartel called for a deep production cut to keep crude prices from falling further as disruption to global business from the coronavirus slashes demand from air travel and industry — deciding Thursday to push for a cut of 1.5 million barrels a day, or about 1.5% of total world supply.

Across the globe, travelers faced ever-greater disruptions, as countries sought to keep the virus out. But South Africa confirmed its first case Thursday, becoming the seventh African nation to report infections. Britain and Switzerland reported their first coronavirus deaths. “The virus doesn’t care about race and belief or color. It is attacking us all, equally,” said Ian MacKay, who studies viruses at the University of Queensland in Australia. The outlook for the travel industry was increasingly grim.

The International Air Transport Association said the outbreak could cost airlines as much as $113 billion in lost revenue. The struggling British airline Flybe collapsed Thursday amid sinking demand. Australia, Indonesia, and the United Arab Emirates were among the countries banning entry from people coming from countries that had outbreaks. Germany’s Lufthansa and its subsidiaries Austrian Airlines and Swiss said they will cancel all flights to and from Israel for three weeks starting Sunday after Israeli authorities announced tough restrictions on travelers from several countries because of the new virus.

Palestinian officials closed the storied Church of the Nativity in the biblical city of Bethlehem indefinitely, weeks ahead of the busy Easter holiday. Japan said visitors from China and South Korea would face a two-week quarantine at a government facility and be barred from public transit. Sri Lankans arriving from Italy, South Korea and Iran will be quarantined at a hospital once used for leprosy patients.

In China, where hospitals were releasing hundreds of recovered patients, officials reported 139 new infection cases and 31 more deaths. Overall, China has reported 80,409 cases and 3,012 deaths, and authorities say about 6,000 people remained hospitalized in serious condition. A state visit to Japan by Chinese President Xi Jinping was postponed. It was to have been the first for a Chinese leader since 2008.