PARIS -- For only the second time in the last 11 years, there will be a new champion at the French Open.

Top-ranked and top-seeded Novak Djokovic dethroned the "King of Clay" on Wednesday, beating nine-time champion Rafael Nadal in a surprisingly lopsided quarterfinal at Court Philippe Chatrier 7-5, 6-3, 6-1.

Significant as the victory was, however, no trophy was handed to Djokovic after the match . He'll have to wait for that as he pursues his first French Open title, which would complete a career Grand Slam.

Next up in the semifinals will be No. 3 Andy Murray, who advanced with a 7-6 (4), 6-2, 5-7, 6-1 victory over No. 7 David Ferrer.

It is only the second defeat for Nadal in 72 career matches at Roland Garros -- and second in 95 best-of-five-set matches anywhere on red clay. It also ended Nadal's 39-match winning streak in Paris.

His other loss came in the fourth round in 2009 against Robin Soderling. Before that, Nadal had won four championships in a row at the French Open. And since? Nadal had collected a record five consecutive French Open trophies.

Novak Djokovic, who advanced to the semifinals, became the first man to win the first two sets against Rafael Nadal in 72 career matches at the French Open. PATRICK KOVARIK/AFP/Getty Images

"I lost in 2009, and (it) was not the end," Nadal said. "I lost in 2015, and (it) is not the end."

The No. 1-ranked Djokovic lost all six previous matches he'd played against Nadal in Paris, including the 2012 and 2014 finals.

But Djokovic was dominant for stretches this time, allowing Nadal only three winners off his heavy topspin lefty forehand, perhaps the most feared shot in all of tennis.

"He was better than me," Nadal said. "That's it."

With his coach, Boris Becker, jumping out of his seat time after time to applaud, Djokovic conjured up 45 winners to only 16 for Nadal, who turned 29 on Wednesday.

Advantage: Djokovic Novak Djokovic and Andy Murray's semifinal matchup will be their first meeting in the French Open and their eighth overall matchup in a Grand Slam event. Grand Slam event Winner '15 French semis ? '15 Australian final Djokovic '14 US Open quarters Djokovic '13 Wimbledon final Murray '13 Australian final Djokovic '12 US Open final Murray '12 Australian semis Djokovic '11 Australian final Djokovic >>Djokovic holds 5-2 edge in GS events

By the end, Djokovic not only had broken down Nadal's game but also his usually unbending will. Appropriately for a match that did not live up to the hype, it closed with a whimper on a double-fault by Nadal.

"I have much respect for Rafa. He is obviously not playing at the level we expect from him this season," Djokovic said. "But he remains a champion, and it's always a pleasure to play against him."

This was only a quarterfinal because Nadal's ranking had slipped so far that he was seeded sixth, despite all of his unprecedented success at the French Open. Nadal missed time last season with a right wrist injury, then had appendix surgery during the offseason.

He has spoken openly about a crisis in confidence from poor-for-him results in 2015: Wednesday's loss was his sixth on clay, his most in a year since 2003. When the new rankings come out Monday, he'll be no better than 10th, his worst spot since April 2005.

Now Djokovic moves into the semifinals as he pursues his first French Open title, which would complete a career Grand Slam. On Friday, the 28-year-old Serb will meet either No. 3 Andy Murray or No. 7 David Ferrer.

Djokovic, who won his eighth Grand Slam title at the Australian Open in January, owns a 27-match winning streak.

"You need to play very well to stand a chance against him, and the truth is that Rafael did not play at his best," said Toni Nadal, who coaches his nephew.

This was the 44th meeting between Djokovic and Nadal, more than any two other men have faced each other in the nearly half-century of professional tennis at major tournaments. And while Nadal still leads 23-21, Djokovic proved to be far superior on this particular late afternoon.

There were only a few puffs of clouds in an otherwise electric blue sky -- matching the color of Nadal's entire ensemble, from headband and wristbands to socks and shoes -- and Djokovic began superbly. He managed to avoid too many lengthy baseline exchanges, mixed in drop shots -- five won points in the opening four games -- and used his backhand to perfection.

"My tactic was to play aggressively and to stay focused on all points," Djokovic said. "It's not easy -- probably easier to say than to actually do it against Rafa."

After 15 minutes, he led 4-0, taking 18 of the first 22 points, including one 19-stroke delight in which both men sprinted to track down lobs.

Then, as though suddenly remembering who he is and where he was, Nadal snapped to it with the help of an on-the-run, down-the-line backhand passing winner so exquisite that Djokovic gave it a thumb's up. That began a stretch of four consecutive games for the Spaniard, making it 4-all.

He couldn't have known it at the time, but that turned out to be Nadal's last surge. He saved three set points while trailing 5-4, then another two at 6-5. But Djokovic converted his sixth chance, breaking Nadal to seize the first set.

Murray defeated Ferrer for the third straight time to reach the French Open semifinals for the second straight year and the third time in his career.

Djokovic leading the third-seeded Briton 18-8 in career matches, but Murray has not lost on clay this season. The two titles he won, at the Madrid Masters and at Munich, are his first on the slow surface.

"He has improved on clay, no doubt about it. I watched him a little bit in Madrid," Djokovic said. "Here he's been playing some really good tennis. He's moving better, serving very well, and he always had a (good) touch."

The other semifinal is Stan Wawrinka vs. Jo-Wilfried Tsonga.

The Associated Press contributed to this report.