This is a copy of a post by Sacremas on Enai's Subreddit

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In case you did not hear, recently there's come up that Skyrim has yet another previously undiscovered potentially game breaking flaw that affects advanced save games, notably ones with 4096 or more cell loads (level loads basically, but the open world of skyirm consists of a lot of separate cells loaded as you travel around) that casue condition based abilites to just fail, this includes perks in Ordinator, Sacrosanct powers and other stuff.

For Enairim if you are noticing strange things happening in an advanced game and you have not been uninstalling mods mid game and you are using Crash Fixes to fix String Count and similar other issues, this can be fixed in Ordinator by respeccing your perks, notably via the Scroll of Legends perk refund function, which will effectively reset the mod until you run into the issue again (after another 4096 loads presumably). For Sacrosanct the maintanance is much more smooth and practically automatic; it happens whenever you feed, so as long as you are feeding at least semi-regularily as a vampire that should be all that's needed. For Imperious you would presumably need to change race, the easiest way to do this and avoid issues is to go back and forth between your race's mortal and vampire shape, this can either be done the regular way or via consoles (setrace to the vampire version of your race like highelfvampire, then back; or the other way if you are already a vampire). However I don't think all races are equally affected by this, my Breton isnt seeing much issues (but I recently became a vampire again so I may have staved it off) but I think the main races affected would be Dunmer, Bosmer and possibly Redguard, due to how their racial abilties work (Ancestors, Harrier and the slow time ability respectably) but I cold be wrong.

For Enai's other mods there is no current reset function, he is looking into them but some may require a complete revision that he doesn't have time for at the moment, according to a post on his Patreon site (where I found out about this initially). Also note that you probably have a lot of other mods as well installed without any reset function, and quite likely without mod authors even aware this is a thing, or still active enough to take care of it... And also note that this even includes some functions in Skyrim itself with no mods at all where it would still happen. Enai reported this to Bethesda and requested a fix but eh, I would not hold your breath on that end, rather expect someone like the Unofficial team, SKSE team or Crash Fixes author to take care of it for them, as usual.

Note that I'm not 100 % certain which specific abilites these include, I was mainly guessing on the Imperious ones, so don't ask me specifically, if anyone else has more specific knowledge on the subject and which abilties could be expected to fail it would be appreciated if you could share"