By Adam Fowler

The berry makes sour things taste sweet Imagine an extract from a berry that would make sour things taste sweet and help you lose weight. Then imagine not being allowed to take it. The world is getting fatter. One billion people are overweight, and 300 million of those are clinically obese. The search is always on for replacements for those things that, eaten in excess, make us obese - fatty and sugary foods. There is no miracle pill that can replace either. Nearly four decades ago one man came close to providing a tablet that could reduce our love of sugar. In the 1960s, Robert Harvey, a biomedical postgraduate student, encountered the miracle berry, a fruit from west Africa which turns sour tastes to sweet. FIND OUT MORE... The Miracle Berry, presented by Tom Mangold, is on Radio 4 at 2100 BST on 28 April Or listen again on the BBC iPlayer "You can eat a berry and then bite into a lemon," says Harvey. "It becomes not only sweeter, but it will be the best lemon you've tasted in your life." More importantly, this "miracle" can be used to manufacture sweet tasting foods without sugar or sweeteners, which have always been plagued by an after-taste. Spotting the potential health benefits, and the healthy profits, that the miracle berry promised, Harvey founded the Miralin Company to grow the berry in Jamaica and Puerto Rico, extract its active ingredient in laboratories in Hudson, Massachusetts, and market it across the United States. At first, Harvey aimed his products at diabetics. "In market testing, diabetics thought our product, as the name implies, was a miracle." But Harvey's sweet dream of making the world healthier came to an abrupt end. On the eve of the launch in 1974, the US Food and Drugs Administration unexpectedly turned against the product. MIRACLE BERRY Also known as "miracle fruit" or Synsepalum dulcificum Grown in Africa, first documented in 18th Century Acts on the sour receptors of the tongue, turning sour tastes sweet Effect lasts 30 mins - two hours Effect is destroyed in hot foods - eg coffee and baked foods Renders an accompanying dry white wine sickly sweet Legal advice and contact with the FDA had led Harvey to believe that the extract from the berry would be allowed under the classification "generally recognised as safe". Having been eaten before meals for centuries in west Africa, without anecdotal reports of problems, it could be assumed not to be harmful. But the FDA decided it would be considered as an additive which required several years more testing. In the poor economic climate of 1974, this could not be funded and the company folded. "I was in shock," says Harvey. "We were on very good terms with the FDA and enjoyed their full support. There was no sign of any problem. Without any opportunity to know what the concern was and who raised it, and to respond to it - they just banned the product." He remembers a number of strange events leading up to the FDA's decision, beginning immediately after one particular market research test. His investors, including Reynolds Metals, Barclays and Prudential, had put up big money. They were looking for big returns. "From the beginning my interest was in the diabetic market but my backers wanted to put double zeros after the numbers we were projecting." Miralin promotional literature

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So, in the summer of 1974, miracle berry ice lollies, in four different flavours, were compared to similar, sugar-sweetened versions by schoolchildren in Boston. The berry won every time. Don Emery, then vice president of the Miralin company, recalls the excitement. "If we had got beyond the diabetic market we could have been a multi-billion dollar company. We'd have displaced maybe millions of tons of sugar and lots of artificial sweeteners as well." A few weeks later, things turned sour. A car was spotted driving back and forwards past Miralin's offices, slowing down as someone took photographs of the building. Then, late one night, Harvey was followed as he drove home. "I sped up, then he sped up. I pulled into this dirt access road and turned off my lights and the other car went past the end of the road at a very high speed. Clearly I was being monitored." Sugar denial Finally, at the end of that summer, Harvey and Emery arrived back at the office after dinner to find they were being burgled. The burglars escaped and were never found, but the main FDA file was left lying open on the floor. A few weeks later the FDA, which had previously been very supportive, wrote to Miralin, effectively banning its product. No co-incidence, according to Don Emery. Obesity is a massive problem in the West "I honestly believe that we were done in by some industrial interest that did not want to see us survive because we were a threat. Somebody influenced somebody in the FDA to cause the regulatory action that was taken against us." The Sugar Association, the trade body representing "Big Sugar" in the US, declined to be interviewed on the subject but flatly denied that the industry had exerted any influence over the FDA. The Calorie Control Council, which represents artificial sweetener manufacturers in the US, has failed to respond to questions on the issue. The Food and Drugs Administration also refused to be interviewed and has indicated that a Freedom of Information (FOI) legislation request to look at the relevant FDA files will not be considered for a year. Robert Harvey had requested the same files over 30 years ago. "We got back the most redacted information I've ever seen from FOI. Everything was blacked out. There would have been material in the file that would have embarrassed the FDA, I believe." Faced with this silence, it's virtually impossible to assess what actually happened to prevent the miracle berry's progress to a sugar-free market. This would be the best lemon you ever tasted But one thing is certain, it never got the chance to prove whether it really would have provided a miracle in our ever fattening world. And for Robert Harvey, that's the biggest shame of all. "It was a big loss not only for my employees and shareholders but, even more importantly, for diabetics and other people with special dietary needs. It was tragic." But all hope is not lost for the berry's champions. Today a firm called BioResources International is trying to produce freeze-dried miracle berry at a plant in New Jersey. Dieters will watch the outcome closely. Below is a selection of your comments. Are we to assume that the non-US market simply wasn't big enough? The FDA, for all their power, have no jurisdiction in, say Canada, Mexico or France. Make it there, sell it for seven years as proof of safety and then ship it back to the States.

Mark Bell, Guildford, England What a surprise. How many foods now have sugar added, that never had sugar before? Things like tinned soups and most heat-and-serve savoury convenience foods have sugar in, and make the food unhealthy. Nobody needs sugar in mince or in any meat foods. Sometimes we need a quick ready meal, and the convenience foods play a role. Are people so used to sugar nothing tastes right without it? We need a Claire Rayner type of person to start a campaign. Fingers crossed for BiResources - this berry could well save lives. The sugar industry has a lot to answer for.

Marian, Hull "Faced with this silence, it's virtually impossible to assess what actually happened to prevent the miracle berry's progress to a sugar-free market." It's easy to assess what might have happened. The sugar companies happened. Far too big an industry to be brought down by a berry. The same would happen with oil companies too, if "they" ever come up with a viable alternative...

Hazel Love, Brighton, UK I remember, years ago, talk of a water injection system for petrol engines to reduce fuel consumption. The inventor claimed he was sabotaged by the big oil companies. So, budding Woodward & Bernsteins, do these big-business conspiracy theories stack up?

Stan Thomas, Wrexham, UK I am a little surprised that the big backers were unable to get to the bottom of it but "Big Sugar" is a massively powerful lobby, with the same approach to health as the cigarette companies.

Dr AGP Laxton, Carmarthen Try putting salt on a grapefruit and you get the same effect. I believe it also sweetens lemons.

Peter Leach, Epping Perhaps he should be invited and welcomed with open arms by the UK govt. to set up business here ? It's an obvious long-term health benefit in the western world, and a potentially valuable cash crop for the developing world.

Peter Jones, Lancaster, England I am diabetic 2,and need to control my diabetes by tablets and watching my diet/food intake. This sounds like someone did not want this to come to market, where it could possibly be of great help to people like me.

Mr John Bryan Jackson, Euxton, Lancs I fail to understand authorities who simply ban such a product, with the potential to perhaps save lives of people who through no fault of their own have a "sweet tooth" and therefore put on weight which simply destroys their quality of life. This "miracle berry" seems to me to reduce the chemicals used to produce sugar substitutes.

Margaret Moore, Portavogie, Co Down, N Ireland



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