Gene Wilder, the comedy actor who shone in such movies as The Producers, Blazing Saddles, Willy Wonka and the Chocolate Factory and Stir Crazy, has died aged 83.

Variety reports that his nephew, Jordan Walker-Pearlman, said he died of complications from Alzheimer’s disease at his home in Stamford, Connecticut on Monday.

Wilder, whose third wife Gilda Radner died of ovarian cancer, was treated for lymphoma in 2000.

Gene Wilder-One of the truly great talents of our time. He blessed every film we did with his magic & he blessed me with his friendship. — Mel Brooks (@MelBrooks) August 29, 2016

He made his name in movies with his portrayals of neurotics and eccentrics in such comedy hits as The Producers, for which he was Oscar-nominated for the role as hyper-tense and sensitive accountant Leo Bloom.

Wilder with co-star Richard Pryor in Silver Streak

He also charmed a whole generation in the lead role in Willy Wonka and the Chocolate Factory and went on to co-write the anarchic spoof Young Frankenstein with Mel Brooks.

Wilder also appeared in the comedy Start the Revolution Without Me and Quackser Fortune Has a Cousin in the Bronx, both in 1970.

Blazing Saddles, Silver Streak and The Frisco Kid followed and in Woody Allen’s 1972 romp Everything You Wanted to Know About Sex, he appeared in a sequence in which he played a doctor who falls in love with a sheep named Daisy.

Wilder's final screen appearances were in the sitcom Will and Grace in 2013 and the TV series Yo Gabba Gabba in 2015.

Wilder made his professional acting debut in Off Broadway’s Roots in 1961, followed by a stint on Broadway itself in Graham Greene’s comedy The Complaisant Lover, which won him a Clarence Derwent Award as promising newcomer.

Mel Brooks spotted Wilder in a 1963 production of Brecht’s Mother Courage, in which Wilder starred with Brooks’ future wife, Anne Bancroft.

Wilder’s stage work also included One Flew Over the Cuckoo’s Nest in 1963 and Dynamite Tonight and The White House the following year.

After various appearances on television, including a 1966 production of Death of a Salesman, he won acclaim as Eugene Grizzard, a kidnapped and rather manic undertaker in Arthur Penn’s Bonnie and Clyde starring Faye Dunaway and Warren Beatty.

He was acclaimed for his turn as The Waco Kid in Brooks's third film, the spoof Western and box office smash Blazing Saddles.

The 1974 movie shot down the myths perpetuated about the American West, pouring light on closeted racism, but it is also stacked full of gags and is often listed among critics' top 10 comedy films.

Farewell #GeneWilder, comic genius. Thank you for all those happy happy hours. pic.twitter.com/O6oHS9TQqX — Stephen Fry (@stephenfry) August 29, 2016

Wilder was close friends with Richard Pryor and their contrasting personas - Wilder uptight, Pryor loose - were ideal for comedy. They co-starred in four films: Silver Streak, Stir Crazy, See No Evil, Hear No Evil and Another You.

But Wilder would insist in a 2013 interview that he was no comedian, saying it was the biggest misconception about him.

"What a comic, what a funny guy, all that stuff! And I'm not. I'm really not. Except in a comedy in films," Wilder said.

"But I make my wife laugh once or twice in the house, but nothing special. But when people see me in a movie and it's funny then they stop and say things to me about 'how funny you were.' But I don't think I'm that funny. I think I can be in the movies."

His last major role was in a TV film version of Alice in Wonderland in the late 1990s, which also starred Ben Kingsley and Martin Short.

"Good Day Sir!"

RIP Gene Wilder — Ricky Gervais (@rickygervais) August 29, 2016

On Monday, Mel Brooks tweeted: "Gene Wilder-One of the truly great talents of our time. He blessed every film we did with his magic & he blessed me with his friendship."

I saw Blazing Saddles 7 times at the cinema with my school friends . George St. Cows outside.

Gene Wilder you were a genius. Rest in Peace. — Russell Crowe (@russellcrowe) August 29, 2016

Ryan Tubridy paid tribute to the late Wilder, saying that he was his role model as presenter of the Late Late Toy Show.

"I very much looked at him as a role model - to be the ringmaster of a bonkers occasion. It’s that twinkle in the eye, the glimmer of madness and kindness, a glimmer that only children can understand", he said.

Irish comedian Dara O Briain tweeted: "Gene Wilder has died. Sad news, but such a life well lived. For me, Young Frankenstein just pips Wonka, but so many wonderful performances.

"Expecting to hear people were fans of Blazing Saddles, Producers and Stir Crazy, but amazing number going for See No Evil, Hear No Evil."

Actor Jim Carrey also paid tribute, saying: "Gene Wilder was one of the funniest and sweetest energies ever to take a human form. If there's a heaven he has a Golden Ticket."

The great genius of comedy Gene Wilder passed today. RIP dear one. You are free to grace the heavens with your light that lifted us all — Goldie Hawn (@goldiehawn) August 30, 2016

Gene Wilder. What a true legend! R.I.P! — Boy George (@BoyGeorge) August 30, 2016

Gene Wilder. Best ever at what he did. #RIP — Ben Stiller (@RedHourBen) August 30, 2016

Gene Wilder ... Hat doffed x — Robbie Williams (@robbiewilliams) August 30, 2016

Some of the hardest laughs in my life were sparked by Gene Wilder. — Donald Faison (@donald_faison) August 30, 2016

RIP Gene Wilder 🙏 Genius. One of a kind. One of the Legends ✨ G #unbeatablecomictiming — the script (@thescript) August 30, 2016