The largest arm of the Bill, Hillary & Chelsea Clinton Foundation will spin off into an independent organization if Hillary Clinton is elected president, the charity said Wednesday in the latest effort by the foundation and the campaign to alleviate concerns about potential conflicts of interest.

If Mrs. Clinton wins in November, former President Bill Clinton, Chelsea Clinton, Bruce Lindsey, Ira C. Magaziner and Maggie Williams will all step down from the board of the charity, the Clinton Health Access Initiative, or CHAI, which was established in 2002 to improve access to AIDS drugs around the world.

The charity also said that the new board would put in place a succession plan for Mr. Magaziner, a longtime friend and adviser to the Clintons, who also serves as the organization’s chief executive.

Under the arrangement, the initiative would be known solely as CHAI. The Clinton name would no longer be used, and the Clinton Foundation would no longer have the power to appoint members to its board.