A pair of 50-plus-year-old married murder suspects busted in a western New York town escaped police custody and are on the run, authorities said.

Blane Barksdale, 56, and Susan Barksdale, 59, of Arizona, were in transit back to their home state from the Rochester suburb of Henrietta when they overpowered two security officers in Blanding, Utah, Monday evening, the Tucson Police Department said in a statement.

They are facing first-degree murder, burglary and arson charges in connection with the death of Frank Bligh, 72, in Tucson in April, according to police and local outlet KVOA.

The duo was likely traveling through Arizona and were last seen in a red GMC Sierra pickup truck with damage to the front passenger side and rear bumper, authorities said.

But at some point, they apparently ditched the truck — it was found north of St. Johns, Arizona, with the couple nowhere in sight, the local outlet reported.

Their direction of travel was unclear.

Authorities say both are considered armed and dangerous, and warned the public not to approach them.

Brent Mallard, the couple’s nephew, has already been arrested on arson, second-degree burglary and felony criminal charges, the local outlet reported.

The FBI, US Marshals and the Apache County Sheriff’s Office joined the search for the escapees, authorities said.