One of the top leaders in the Mormon Church acknowledged in an address to the church’s global membership on Saturday that past leaders had “made mistakes” that had caused some Mormons to have doubts, an admission that amounts to a significant change in tone in the leadership’s approach to Mormons who question, dissent or defect from the church.

“We respect those who honestly search for truth,” President Dieter F. Uchtdorf, second counselor in the church’s top governing body, the first presidency, said in the speech.