This article originally appeared in the February 2017 issue of ELLE.

There was one undeniable high note in last fall's election results: the passing of pro-pot legislation in California, Nevada, North Dakota, Florida, Maine, Massachusetts, and Arkansas, which made some form of marijuana use—either medical or recreational—legal, or soon to be legal, in a total of 29 states. Ever since the drug began being gradually decriminalized state by state 20 years ago, entrepreneurs in areas with the most relaxed laws have seized upon the, er, growth opportunities, infusing extracts of the plant into everything from dog treats to chewing gum to bath salts. And now that it's permissible to consume the stuff in certain bars and restaurants in Denver, we may soon have our own Amsterdam in the Rockies. This sea change in America's attitude toward cannabis isn't just a boon for budding Jeff Spicolis: New uses for the therapeutic herb are emerging that could revolutionize the way we treat everything from menstrual cramps and mosquito bites to acne and wrinkles.

The components of the cannabis plant that enable it to assuage maladies such as migraines and certain seizure disorders are compounds called cannabinoids, found within its leaves and flowers. The most well-known are tetrahydrocannabinol (THC), which gives weed its psychoactive properties, and cannabidiol (CBD), which is naturally found in higher concentrations in industrial hemp strains. (Marijuana and hemp are variations of the same plant type. The former has been cultivated to have higher THC; the latter, to have more robust stalks—which can be used to make paper, rope, and textiles—and a negligible THC content of less than .3 percent.) The reason these cannabinoids have such profound effects on us—whether ingested or applied topically—is that we are biologically primed to use them.

The human body actually has an endocannabinoid system, through which it produces its own cannabinoids. It's been known since the 1990s that these compounds play a role in regulating functions such as skin sensitivity, appetite, and even memory. (Fun fact: One of the cannabinoids produced in the brain, anandamide, is the same chemical in chocolate that makes us feel euphoric when we consume it.) The two main types of cannabinoid receptors, which are embedded within the membrane of virtually every cell type, are integral to the nervous and immune systems. When we add cannabinoids from plants (similar molecules are also present in chili peppers and echinacea, among others), they can interact with these receptors to help our own endocannabinoid system function more effectively, keeping internal processes, such as those that govern our stress response, stable and balanced. Some of the many issues that have been linked to an out-of-whack endocannabinoid system include neurological disorders, obesity, and high blood pressure.

CBD has no psychoactive properties and, unlike THC, can be sold in all 50 states as long as it's derived specifically from industrial hemp. (THC-laced products can be sold only in states with relaxed cannabis laws and cannot be sent or transported to other parts of the country.) CBD is also considered the most medically active of the two compounds, with research showing that it might help with anxiety and systemic inflammation, as well as mitigate some of the side effects of chemotherapy when taken orally. Applied to the skin, it can diminish localized pain—indeed, the first CBD products to hit the market were designed primarily to target sore muscles and arthritis. Now CBD is turning up in everything from face serums to lip balms, and with mounting studies substantiating its efficacy and versatility, what we're currently seeing may be just the beginning.

"My research group was among the first to investigate whether the skin is capable of producing endocannabinoids, and apparently most, if not all, skin functions are controlled to a certain extent by the local skin endocannabinoid system," says Tamás Bíró, PhD, director of the immunology department at the University of Debrecen, Hungary, and an adviser for Phytecs, a biotech company that researches and develops products targeting the endocannabinoid system for the medical, nutraceutical, and cosmetic industries. "This includes the skin barrier, which is very important for moisture retention, sebum production, and sweat-gland function, as well as skincentric sensory functions such as pain and itch. But perhaps most important, it appears that the endocannabinoid system controls skin inflammation—so if an inflammatory or irritation challenge assaults the skin, the endocannabinoid system fights against it." This could potentially make cannabinoids useful antiaging ingredients, and, Bíró speculates, due to their capacity to regulate sebum, they might turn out to be especially potent tools for fighting acne, although studies are still in the preclinical stages: "We found that when we applied CBD to human skin cells in a Petri dish," he says, "it prevented the inflammation and high production of sebum" associated with breakouts.

"Cannabinoids haven't really emerged in mainstream dermatology," says Adam Friedman, MD, associate professor of dermatology at George Washington University, who is currently developing methods for nanoparticle delivery of CBD through the skin. "But I think that's going to change. Given that there is a wide array of skin conditions notorious for chronic inflammation and debilitating itch or pain, there are numerous potential applications. There's going to be an exponential increase in the attention paid to this in the derm world."

At this early stage, there are still some questions about how topical cannabinoids should be formulated and dosed. While CBD has emerged as the star player in most lotions and potions currently cropping up from niche brands across the country, evidence does suggest that its effects can be boosted by combining it with other active molecules from the cannabis plant, including THC and/or terpenes, the phytochemicals that give pot its distinctive aroma. (This phenomenon, known as the entourage effect, was first recognized by Raphael Mechoulam, PhD, the Israeli organic chemist who identified the presence of THC and CBD in cannabis in the 1960s.) Many brands—such as Whoopi Goldberg's Whoopi & Maya line, which was created to relieve period pain, and Los Angeles–based luxury brand Lord Jones, whose chicly packaged, edible THC–laced gummies and chocolates are Instagram gold—are formulated with both CBD and THC. Other brands, targeting states with stricter antimarijuana laws, stick with straight-up CBD that has been extracted in a way that retains many other naturally occurring (but legal) molecules, such as terpenes and flavonoids. (And some brands do both, such as Colorado-based Apothecanna, which creates two versions of each of its products, one with THC and one without, to suit different markets.) But even in small doses, CBD alone appears to be beneficial. "Because the skin has its own endocannabinoid system, just the superficial application of CBD by itself is extremely helpful," says Raj Gupta, chief scientific officer of Colorado Springs–based Folium Biosciences, a company that produces ultrapremium, THC-free, phytocannabinoid-rich hemp oil. "CBD is an antioxidant, so you can see changes in skin pattern, such as a reduction in hyperpigmentation."

In order to ensure that the product you're using contains high-quality cannabinoids, the best bet is to buy from a brand sold at a medical dispensary or trusted retailer. Also, don't worry that the creams, even those containing THC, are going to make you feel high. "Topical preparations have insignificant systemic absorption and are not known to cause psychoactive effects," says anesthesiologist Debra Kimless, MD, who specializes in cannabis and pain management and serves as medical director for ForwardGro, a medical-cannabis cultivating and research company based in Maryland. "Some patients claim that they feel relaxed, usually because they are experiencing pain relief." Kimless does caution, however, that while no studies have tested topical THC's ability to make it into the bloodstream, "there is always a chance" that it could show up in a drug test.

Although cannabis has been used both medicinally and recreationally for thousands of years—and was a primary ingredient in some mainstream pharmaceuticals in the early 1900s—it has been largely unstudied in the United States since 1937's Marihuana Tax Act, which effectively banned its use and sale. That's all changing, albeit slowly, as the stigma of conducting clinical tests involving an illegal drug fades away. Still, says Friedman, we have a long way to go before the cannabis plant, which contains scores more yet-unstudied cannabinoids beyond CBD and THC, is fully understood—not to mention the full effects each of those individual cannabinoids have when applied to skin. "It's such a cool field, but so much of the information we have is still limited and early on," he says. "There are probably a lot more questions than answers at this point, but I think we're going to see a lot more research coming down the pike."

CBD

As long as it's derived from industrial hemp, CBD can be sold in any of the 50 states.

1. CBD Care Garden Face Karma Anti-Aging Moisturizer ($94.68, cbdcaregarden.com) replenishes skin with Swiss apple stem cells and peptides, as well as 20 mg of pure CBD.

2. Apothecanna Calming Body Oil ($36, apothecanna.com), which soothes muscles with a blend of lavender, chamomile, frankincense, and CBD, is a best-seller at New York eco-emporium CAP Beauty.

3. CBD For Life 99% Pure CBD Extract Pain Relief Spray ($26.99, cbdforlife.us) nixes aches and pains with a potent combo of cannabinoid extract, arnica, menthol, and camphor.

THC

Products containing THC can be sold only in states where cannabis has been legalized for medical or recreational use.

1. Dixie Synergy Relief Balm contains 50 mg of both CBD and THC per container to treat localized pain and inflammation.

2. Originally devised for use in the founders' Hollywood wellness practice, Lord Jones High CBD Pain & Wellness Formula Body Lotion, currently sold only in California, combines CBD and THC in a five-to-one ratio to diminish discomfort from pulled muscles, arthritis, and eczema.

3. Available in California and Colorado, Foria Pleasure spray ($38, foriapleasure.com)—think weed lube—promises to boost bedtime fun with sensation-heightening cannabis and coconut oils.

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