Schumer, who recently dropped her pants for a good cause, has openly rallied against gun violence on multiple occasions.

The comedienne previously made public appearances with her cousin, Sen. Chuck Schumer, in an effort to speak against gun violence and to raise awareness on the dangerous matter. "Gun violence is ripping apart America; it's ripping apart our families," she said at an October press conference with Sen. Schumer.

"And even those untouched by violence must every few days just look up in a stunned silence at another nightly newscast that reads like an obituary."

More recently, she tackled the conversation with a more comedic approach by performing a sketch called "Welcome to the Gun Show" on Inside Amy Schumer. In it, the star poses as a host for a Home Shopping Network-type of show to illustrate how easy it is to obtain a gun.

"Now here is what's great about this," says Schumer, playing with the gun for the camera. "Pretty much anyone can purchase this." She continued, "You can absolutely get a gun if you have several felonies, as long as you buy it on the Internet or at a gun show."

Unfortunately, one of Schumer's films was the setting for a different shooting. In July 2015, a gunman opened fire at a showing of Trainwreck, killing two people and injuring others before killing himself.

"I was by myself in a hotel, and I was just like, I wish I never wrote that movie," Schumer said in an interview with Vanity Fair. "It's like when the Dark Knight shooting happened, and in Paris. The idea of people trying to go out and have a good time—you know, like looking forward to it?—I don't know why that makes me the saddest."