SENOLYTICS — SEEK AND DESTROY

According to modern science aging is the accumulation of damage that the body cannot completely eliminate, due to the imperfections of its protection and repair systems. The good news is that the processes that constitute aging are amenable to medical intervention. We can slow down or even reverse some aspects of aging through the application of different therapies, which prevent or block some of these processes.

One of these processes of aging is cell senescence.

Senescent cells normally self destruct via a process called apoptosis, but unfortunately not all of them do. These “death resistant” senescent cells accumulate in the body with age and secrete toxic signals. This causes inflammation and damage to organs and tissues, increasing risks for cancer and other diseases of old age. This is why these cells are often called “good citizens but bad neighbors”. They remain partially functional, but their presence does more harm than good.



A new class of drugs known as Senolytics have recently demonstrated the ability to remove senescent cells to improve health. However, the potential of senolytics to increase health and lifespan beyond current maximums remains unknown. This is what we at Major Mouse Testing Program want to investigate – with your help!

Why is this study of particular interest?



It was discovered that senescent cells have increased expression of pro-survival genes, consistent with their resistance to natural cell death – apoptosis. Drugs targeting these pro-survival factors selectively killed senescent cells and improved health. Two such drugs were Dasatinib and Quercetin which were both able to remove senescent cells, albeit each in different tissue types. Even more excitingly it was discovered that a combination of the two drugs formed a synergy that was significantly more effective at removing some senescent cell types.

Venetoclax has also recently been discovered to be senolytic in nature and is a therapy we wish to explore as part of our combination testing. In cancer therapy Venetoclax has shown to work well with Dasatinib so we are interested in seeing if this can be applied to clearing senescent cells too.

Recent studies have shown removing senescent cells mitigates age related decline and improves healthy lifespan. Additional studies have shown that clearance of senescent cells is beneficial for cardiovascular health and lowers high cholesterol levels in the blood. This strongly suggests that Senolytics may be a viable therapeutic approach to combat aging.

In our study we have opted to treat already naturally aged mice. These mice will be 16-18 months old (equivalent to a human of approximately 60 years old). This has two advantages: we speed up research, and also demonstrate the feasibility of translating Senolytics to already middle aged or older humans.

Dasatinib and Venetoclax are already approved for use in humans to treat specific diseases, and Quercetin is a readily available supplement, so the application of these drugs or improved versions based upon them to prevent and postpone age-related damage to health could be developed relatively quickly.

Senolytics and Stem Cells

So far senolytics have only been shown to reduce the number of senescent somatic cells, but what effect do they have on stem cells? This has not been closely studied, and is a question we intend to fully answer in addition to the implications this presents for lifespan.

It is entirely possible that Senolytics taken alone may not extend maximum lifespan, but rather healthspan. Even if this is the case, it is no reason to be discouraged. What we learn in this first phase, paves the way for our next step – combining Senolytics with Stem Cell Therapy to encourage tissue regeneration.

About our lead researcher

Dr Alexandra Stolzing is our chief researcher and a world class expert in her field, with over fifteen years in the medical research field, and a decade of work in regenerative medicine, Alexandra brings substantial experience to our project. She has worked with stem cell transplants and and is keen to explore new possibilities in the rapidly advancing field of regenerative medicine.

As part of our commitment to the sharing of scientific research the team plans to publish the results of our research as open access. We believe that knowledge should be shared and this is the level of our contribution to sharing and growing as a community together.

$5 — Our Eternal Gratitude! Thank you very much for supporting the cause of healthy longevity! By donating you are pushing the investigation of longevity therapies forward and helping to obtain healthy longevity for all people. We will proudly put you on the list of campaign supporters on our website as a thank you for your support.

$20 — E-Book “Aging Prevention for All”



Get the new beautiful electronic English version of Aging Prevention for All compatible with your computer, tablet or mobile phone. This book, developed by the team of the International Longevity Alliance together with famous gerontologist and longevity researcher Vladimir Anisimov, will provide you with an overview on aging processes and the practical evidence-based advice on the available healthy life extension techniques.

$25 — $20 Pledge Reward + E-Book “Death is Wrong”



We will send you the electronic version of the book Death is Wrong by Gennady Stolyarov; a story about aging and how society might change the way they think about it. It is available in English, Russian, French, Spanish, and Portuguese. We will also thank you on social media and give you the e-book Aging Prevention for All!

$50 — A Stylish MMTP T-Shirt!



Put the sexy back into science – get an awesome MMTP T-shirt to amaze your friends! We will follow up with you to select a size and choose one of our three beautiful designs. + $10 for international shipping.

$60 — $20 Pledge Reward + Science Mouse T-Shirt



Wear our new special edition T-shirt that shows you are a true science geek and also receive a copy of our lovely new E-book “Aging Prevention for All”. You can also opt to have the alternative T-shirt with MMTP logo if you prefer. We will follow up with you to select a size. + $10 for international shipping.

$70 — MMTP T-Shirt and 2 E-Books Combo!



Your chance to receive a stunning MMTP T-shirt combined with two interesting electronic books: Aging Prevention for All and Death is Wrong! + $10 for international shipping.

$75 — Science Mouse T-Shirt + Gene Therapy Conference Ticket!



Get the awesome special edition MMTP T-shirt that shows you are a true science geek as well as a ticket to the exciting D.N.A.- Gene Therapies Congress – 9th July Utrecht, Netherlands. Speakers will include Aubrey de Grey, Elizabeth Parrish, Oliver Medvedik, Tatjana Kochetkova, and Keith Comito. You may also choose to have the alternative T-shirt with MMTP logo if you prefer. We will follow up with you to select a size. Travel not included. + $10 for international shipping.

$100 — Signed Copy of “Aging Prevention for All” + 1 E-Book of Your Choice



A physical copy of Aging Prevention For All, signed by the authors and sent to you with best wishes! You will also be able to choose an e-book of either Ending Aging, The Singularity is Near, or The Telomerase Revolution. We hope you will enjoy your reading! + $10 for international shipping.

$150 — ILA Sports Bag + E-Book “Aging Prevention for All”



Did you know that physical activity can significantly influence your lifespan? Well, it can! Receive this stylish ILA sports bag to support your motivation to be in a good shape and live longer! You will also receive our e-book Aging Prevention for All to help you learn about the science of healthy longevity. + $10 for international shipping.

$200 — ILA Sports Bag + 2 MMTP T-Shirts Combo + E-Book “Aging Prevention for All”



A stylish ILA sports bag and 2 MMTP T-shirts all together to support your motivation to be in a good shape and live longer! You will also receive our e-book Aging Prevention for All to help you learn about the science of healthy longevity. + $10 for international shipping.

$250 — ILA Sports Bag, MMTP T-Shirt, and Name a Mouse!



Name a mouse in the experiment and follow his/her life course. If it is in the longest lived you will get a special secret prize. We have only 40 mice to name so this opportunity is limited. The electronic version of Aging Prevention for All is also yours! You also receive the MMTP T-shirt and an ILA sports bag! + $10 for international shipping.

$500 — Meet the Team Online + E-Book Collection!



You will get to meet the project team online in two personal 30-minute video conferences and we will share the most exciting news about the ongoing experiment! You can also ask us any questions: the most promising directions of scientific research, fresh news from other researchers, our favorite methods of life extension, tips on health behavior changes, and of course the initiatives for longevity advocacy. It would be a pleasure to talk with like-minded people! Our beautiful electronic version of Aging Prevention for All is also yours! And we will also provide you with the electronic versions of all other books: Ending Aging, Singularity is Near, and Telomerase Revolution and Death is Wrong in order to amplify your knowledge even more!

$1000 — Online panel discussion: “How to promote longevity?”



Join a 1.5 hour online discussion with the MMTP project team and several invited experts to discuss the latest breakthroughs in life extension research as well as the best ways to promote the idea of aging prevention among general public. You will also receive a a stylish MMTP T-shirt and an ILA sports bag to commemorate the event. + $10 for international shipping.

$2000 — A Ticket to European Longevity Conference + Silver Sponsorship Recognition



Receive a ticket to attend Eurosymposium on Healthy Ageing (EHA), organized in Brussels by our partner HEALES, in October 2016. Travel costs are not included in this perk. We will also mention you as a Silver sponsor of our Senolytics campaign and promote you (or your company*) in all media activities during the campaign and until the experiment begins. *Please check the disclaimer on the MMTP website.