Experience Based Guidance

Per my experience if you are comfortable with any loadout you should still be fine in a decent team, but where the real challenge comes in is if the whole team or majority are using random loadouts and the team overall is deficient in some regard.The most challenging scenario that doesn't happen without team using random loadouts so far has been team overall lacking on ammo Resupply which leaves dying and getting reinforced as main way of getting Primary Weapon ammo back and no way to Resupply Support Weapons if those were in your loadout.At least for me:Using random loadouts is easiest vs the Illuminates because they can be handled with pretty much any loadout including in Retaliatory Strike missions. As long as you have ammo, you can rule them with any loadout.The Bugs are in the middle on difficulty curve, but if team is good at suppressing their Scouts (at least during certain objecties) and running away when there is no more need to fight, then easy enough. For Retaliatory Strikes, if team has at least some Stun / Poison and some AT options, I think most decent teams even using random loadouts will generally be able to get through.The Cyborgs are the toughest because if you are deficient in team on either ammo or AT options, then it is very hard to keep objectives from failing, and team mates from dying. For the Retaliatory Strikes you minimally need good rolls with plenty of AT (and hopefully some Stun). If your loadouts are not ideal or familiar and team overall deficient on AT, expect to use Reinforce a lot or give up and try a new re-roll on random loadouts until you have something you think is more feasible.For the Enemy masters, all Primary Weapons damage the Hive Lord and Great Eye and all but a few Support Weapons can also damage them, but for the Siege Mech you need sufficient AT weaponry otherwise you are wasting time with only way to hurt it to drop Reinforce hellpods on it.Beyond that you have the terrain types:Probably Snow will be most challenging if your random loadouts don't give you All Terrain Boots or LIFT-850 Jump Pack, and you are not practiced on Snow without those options. If you are without the things that make Snow easier, ultimately it just requires better team work, and better fight or flight choices, using cover, being aware of ice vs snow patches, being reliable at reinforcing, being mindful of where you throw reinforces, and other such things that are useful on non-Snow maps, but more critical on Snow maps.Forest can be just as tough where objectives can be right in, or near swamps. Additionally, they are the longest map types with objectives that are far apart and swamps in between. If you stop to fight unnecessarily along the way and have limited ammo / stratagem uses you could run out and then be even more handicapped.Volcanic are next most difficult, but only specially around areas where there are volcanoes. The rest of it you can treat like Desert.Desert and City are the easiest. Maybe when first starting to use random loadouts stick to these so you are faced with least challenge by the terrain until you are more practiced with wider variety of possible loadout mixes. I would say City is easiest overall as long as you don't try to fight in narrow corridors.