Although they’re not related, the musical-comedy team Savannah & Chase, a.k.a. Savannah Brown and Chase O’Donnell, might be described as the Smothers Sisters. “Too Blondes,” their goofy, effervescent show at the Metropolitan Room on Wednesday evening, began with the kind of comedic confusion that used to be a running joke in Tom and Dick Smothers’ television variety show.

Wide-eyed and with an expression of manic mischief, Ms. Brown arrived onstage dressed like a flapper, in the belief that their show’s theme was “Life in the ’20s.” Ms. O’Donnell insisted that it was “Life in our 20s.” The misunderstanding persisted for the rest of the evening, as the competing concepts amusingly bumped against each other. Their upbeat camaraderie had the tone of an episode of the popular Comedy Central series “Broad City.”