Incarcerated individuals in the United States are reportedly four times more likely to be infected with HIV than members of the general population, and a substantial proportion have a history of drug use. Postincarceration, many struggle to maintain their antiretroviral therapy (ART) regimen. This pilot study tested the potential performance of two ART adherence interventions, Project ADHerence Education and Risk Evaluation (ADHERE) and Medication Adherence and Care Engagement (MACE) among drug-using HIV-infected formerly incarcerated individuals in New York City. Thirty participants were randomized and completed the ADHERE or MACE intervention. Participants were interviewed and had their blood drawn for viral load testing at baseline and 3 months postintervention. Our findings suggest that drug-using HIV-infected formerly incarcerated individuals can benefit from brief ART adherence interventions. They also suggest that marijuana use may not have a negative impact on ART adherence.

References

Altice, F. L., Mostashari, F., Friedland, G. H. ( 2001 ). Trust and the acceptance of and adherence to antiretroviral therapy . Journal of Acquired Immune Deficiency Syndromes, 28, 47 – 58 .

Google Scholar Crossref | Medline | ISI

Amico, K. R., Barta, W., Konkle-Parker, D. J., Fisher, J. D., Cornman, D. H., Shuper, P. A., Fisher, W. A. ( 2009 ). The information-motivation-behavioral skills model of ART adherence in a Deep South HIV+ clinic sample . AIDS and Behavior, 13, 66 – 75 . http://doi.org/10.1007/s10461-007-9311-y

Google Scholar

Bangsberg, D. R., Perry, S., Charlebois, E. D., Clark, R. A., Roberston, M., Zolopa, A. R., Moss, A. ( 2001 ). Non-adherence to highly active antiretroviral therapy predicts progression to AIDS . AIDS, 15, 1181 – 1183 . http://doi.org/10.1097/00002030-200106150-00015

Google Scholar

Baum, M. K., Rafie, C., Lai, S., Sales, S., Page, B., Campa, A. ( 2009 ). Crack-cocaine use accelerates HIV disease progression in a cohort of HIV-positive drug users . Journal of Acquired Immune Deficiency Syndromes, 50, 93 – 99 . http://doi.org/10.1097/QAI.0b013e3181900129

Google Scholar

Binswanger, I. A., Blatchford, P. J., Lindsay, R. G., Stern, M. F. ( 2011 ). Risk factors for all-cause, overdose and early deaths after release from prison in Washington state . Drug and Alcohol Dependence, 117, 1 – 6 . http://doi.org10.1016/j.drugalcdep.2010.11.029

Google Scholar

Binswanger, I. A., Nowels, C., Corsi, K. F., Long, J., Booth, R. E., Kutner, J., Steiner, J. F. ( 2011 ). Return to drug use and overdose after release from prison: A qualitative study [Abstracts from the 2010 AMERSA National Meeting] . Substance Abuse, 32, 57 – 58 . http://doi.org/10.1080/08897077.2011.540500

Google Scholar

Blower, S. M., Gershengorn, H. B., Grant, R. M. ( 2000 ). A tale of two futures: HIV and antiretroviral therapy in San Francisco . Science, 287, 650 – 654 . http://doi.org/10.1126/science.287.5453.650

Google Scholar

Catz, S. L., Thibodeau, L., BlueSpruce, J., Yard, S. S., Seal, D. W., Amico, K. R., Bogart, L. M., Mahoney, C., Balderson, B. H., Sosman, J. M. ( 2012 ). Prevention needs of HIV-positive men and women awaiting release from prison . AIDS and Behavior, 16, 108 – 120 .

Google Scholar Crossref | Medline | ISI

Centers for Disease Control and Prevention . ( 2006 ). HIV transmission among male inmates in a state prison system: Georgia, 1992-2005 . Morbidity and Mortality Weekly Report, 55, 421 – 426 .

Google Scholar Medline

Colfax, G., Coates, T. J., Husnik, M. J., Huang, Y. J., Buchbinder, S., Koblin, B., Chesney, M., Vittinghoff, E., & EXPLORE Study Team . ( 2005 ). Longitudinal patterns of methamphetamine, popper (amyl nitrite), and cocaine use and high-risk sexual behavior among a cohort of San Francisco men who have sex with men . Journal of Urban Health, 82, i62 – i70 . http://doi.org/10.1093/jurban/jti025

Google Scholar

Copenhaver, M., Chowdhury, S., Altice, F. L. ( 2009 ). Adaptation of an evidence-based intervention targeting HIV-infected prisoners transitioning to the community: The process and outcome of formative research for the Positive Living Using Safety (PLUS) intervention . AIDS Patient Care and STDS, 23, 277 – 287 . http://doi.org/10.1089/apc.2008.0157

Google Scholar

Dargere, S., Parienti, J. J., Verdon, R. ( 2007 ). Treatment resistance after sequential interruption of a non-nucleoside reverse transcriptase inhibitor-based regimen . AIDS, 21, 879 – 880 . http://doi.org/10.1097/Qad.0b013e3280b077b6

Google Scholar

de Jong, B. C., Prentiss, D., McFarland, W., Machekano, R., Israelski, D. M. ( 2005 ). Marijuana use and its association with adherence to antiretroviral therapy among HIV-infected persons with moderate to severe nausea . Journal of Acquired Immune Deficiency Syndromes, 38, 43 – 46 . http://doi.org/10.1097/00126334-200501010-00008

Google Scholar

Diallo, D. D., Moore, T. W., Ngalame, P. M., White, L. D., Herbst, J. H., Painter, T. M. ( 2010 ). Efficacy of a single-session HIV prevention intervention for black women: A group randomized controlled trial . AIDS and Behavior, 14, 518 – 529 . http://doi.org/10.1007/s10461-010-9672-5

Google Scholar

Doherty, M. ( 2014 ). WHO guidelines on the use of CD4, viral load and EID tests for initiation and monitoring of ART. World Health Organization . http://www.who.int/hiv/amds/102_WHO_Guidelines_on_CD4_and_VL_for_ART_Doherty.pdf?ua=1

Google Scholar

D’Souza, G., Matson, P. A., Grady, C. D., Nahvi, S., Merenstein, D., Weber, K. M., Greenblatt, R., Burian, P., Wilson, T. E. ( 2012 ). Medicinal and recreational marijuana use among HIV-infected women in the Women’s Interagency HIV Study (WIHS) cohort, 1994-2010 . Journal of Acquired Immune Deficiency Syndromes, 61, 618 – 626 . http://doi.org/10.1097/QAI.0b013e318273ab3a

Google Scholar

Du, P., Crook, T., Whitener, C., Albright, P., Greenawalt, D., Zurlo, J. ( 2015 ). HIV transmission risk behaviors among people living with HIV/AIDS: The need to integrate HIV prevention interventions and public health strategies into HIV care . Journal of Public Health Management and Practice, 21, E1 – E10 . http://doi.org/10.1097/Phh.0000000000000038

Google Scholar

Durose, M. R., Cooper, A. D., Snyder, H. N. ( 2014 ). Recidivism of prisoners released in 30 states in 2005: Patterns from 2005 to 2010 (NCJ 244205). Bureau of Justice Statistics .

Google Scholar

Eaton, L. A., Huedo-Medina, T. B., Kalichman, S. C., Pellowski, J. A., Sagherian, M. J., Warren, M., Popat, A. R., Johnson, B. T. ( 2012 ). Meta-analysis of single-session behavioral interventions to prevent sexually transmitted infections: Implications for bundling prevention packages . American Journal of Public Health, 102, e34 – 44 . http://doi.org/10.2105/AJPH.2012.300968

Google Scholar

Fazel, S., Bains, P., Doll, H. ( 2006 ). Substance abuse and dependence in prisoners: A systematic review . Addiction, 101, 181 – 191 . http://doi.org/10.1111/j.1360-0443.2006.01316.x

Google Scholar

Fazel, S., Yoon, I. A., Hayes, A. J. ( 2017 ). Substance use disorders in prisoners: An updated systematic review and meta-regression analysis in recently incarcerated men and women . Addiction, 112, 1725 – 1739 . http://doi.org/10.1111/add.13877

Google Scholar

Gross, R., Bellamy, S. L., Chapman, J., Han, X. Y., O’Duor, J., Palmer, S. C., Houts, P. S., Coyne, J. C., Strom, B. L. ( 2013 ). Managed problem solving for antiretroviral therapy adherence a randomized trial . JAMA Internal Medicine, 173, 300 – 306 . http://doi.org/10.1001/jamainternmed.2013.2152

Google Scholar

Guerino, P., Harrison, P. M., Sabol, W. J. ( 2011 ). Prisoners in 2010 (NCJ 236096). Bureau of Justice Statistics .

Google Scholar

Hall, H. I., Holtgrave, D. R., Maulsby, C. ( 2012 ). HIV transmission rates from persons living with HIV who are aware and unaware of their infection . AIDS, 26, 893 – 896 . http://doi.org/10.1097/QAD.0b013e328351f73f

Google Scholar

Hammett, T. M., Roberts, C., Kennedy, S. ( 2001 ). Health-related issues in prisoner reentry . Crime & Delinquency, 47, 390 – 409 .

Google Scholar SAGE Journals | ISI

Hermankova, M., Ray, S. C., Ruff, C., Powell-Davis, M., Ingersoll, R., D’Aquila, R. T., Quinn, T. C., Siliciano, J. D., Siliciano, R. F., Persaud, D. ( 2001 ). HIV-1 drug resistance profiles in children and adults with viral load of <50 copies/ml receiving combination therapy . Journal of the American Medical Association, 286, 196 – 207 . http://doi.org/10.1001/jama.286.2.196

Google Scholar

Iroh, P. A., Mayo, H., Nijhawan, A. E. ( 2015 ). The HIV care cascade before, during, and after incarceration: A systematic review and data synthesis . American Journal of Public Health, 105, e5 – e16 . http://doi.org/10.2105/Ajph.2015.302635

Google Scholar

Jones, K. T., Johnson, W. D., Wheeler, D. P., Gray, P., Foust, E., Gaiter, J., & North Carolina Men’s Health Initiative Study Team . ( 2008 ). Non supportive peer norms and incarceration as HIV risk correlates for young black men who have sex with men . AIDS and Behavior, 12, 41 – 50 . http://doi.org/10.1007/s10461-007-9228-5

Google Scholar

Kaeble, D., Cowhig, M. ( 2018 ). Correctional populations in the United States, 2016 . Bureau of Justice Statistics. Report #NCJ251211. Washington, DC .

Google Scholar

Kalichman, S. C., Cherry, C., Kalichman, M. O., Amaral, C. M., White, D., Pope, H., Swetzes, C., Eaton, L., Macy, R., Cain, D. ( 2011 ). Integrated behavioral intervention to improve HIV/AIDS treatment adherence and reduce HIV transmission . American Journal of Public Health, 101, 531 – 538 . http://doi.org/10.2105/Ajph.2010.197608

Google Scholar

Kalichman, S. C., Ramachandran, B., Catz, S. ( 1999 ). Adherence to combination antiretroviral therapies in HIV patients of low health literacy . Journal of General Internal Medicine, 14, 267 – 273 . http://doi.org/10.1046/j.1525-1497.1999.00334.x

Google Scholar

Leaver, C. A., Bargh, G., Dunn, J. R., Hwang, S. W. ( 2007 ). The effects of housing status on health-related outcomes in people living with HIV: A systematic review of the literature . AIDS and Behavior, 11, 85 – 100 . http://doi.org/10.1007/s10461-007-9246-3

Google Scholar

Liu, H. H., Miller, L. G., Hays, R. D., Golin, C. E., Wu, T. T., Wenger, N. S., Kaplan, A. H. ( 2006 ). Repeated measures longitudinal analyses of HIV virologic response as a function of percent adherence, dose timing, genotypic sensitivity, and other factors . Journal of Acquired Immune Deficiency Syndromes, 41, 315 – 322 . http://doi.org/10.1097/01.qai.0000197071.77482.6e

Google Scholar

Malta, M., Strathdee, S. A., Magnanini, M. M., Bastos, F. I. ( 2008 ). Adherence to antiretroviral therapy for human immunodeficiency virus/acquired immune deficiency syndrome among drug users: A systematic review . Addiction, 103, 1242 – 1257 . http://doi.org/10.1111/j.1360-0443.2008.02269.x

Google Scholar

Marks, G., Crepaz, N., Senterfitt, J. W., Janssen, R. S. ( 2005 ). Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: Implications for HIV prevention programs . Journal of Acquired Immune Deficiency Syndromes, 39, 446 – 453 . http://doi.org/10.1097/01.qai.0000151079.33935.79

Google Scholar

Marks, G., Gardner, L. I., Rose, C. E., Zinski, A., Moore, R. D., Holman, S., Rodriguez, A. E., Sullivan, M., Giordano, T. P. ( 2015 ). Time above 1500 copies: A viral load measure for assessing transmission risk of HIV-positive patients in care . AIDS, 29, 947 – 954 . http://doi.org/10.1097/Qad.0000000000000640

Google Scholar

Merrall, E. L., Kariminia, A., Binswanger, I. A., Hobbs, M. S., Farrell, M., Marsden, J., Hutchinson, S. J., Bird, S. M. ( 2010 ). Meta-analysis of drug-related deaths soon after release from prison . Addiction, 105, 1545 – 1554 . http://doi.org/10.1111/j.1360-0443.2010.02990.x

Google Scholar

Mimiaga, M. J., Reisner, S. L., Grasso, C., Crane, H. M., Safren, S. A., Kitahata, M. M., Schumacher, J. E., Mathews, W. C., Mayer, K. H. ( 2013 ). Substance use among HIV-infected patients engaged in primary care in the United States: Findings from the centers for AIDS research network of integrated clinical systems cohort . American Journal of Public Health, 103, 1457 – 1467 . http://doi.org/10.2105/Ajph.2012.301162

Google Scholar

Raffa, J. D., Tossonian, H. K., Grebely, J., Petkau, A. J., DeVlaming, S., Conway, B. ( 2008 ). Intermediate highly active antiretroviral therapy adherence thresholds and empirical models for the development of drug resistance mutations . Journal of Acquired Immune Deficiency Syndromes, 47, 397 – 399 .

Google Scholar Crossref | Medline | ISI

Rowell-Cunsolo, T. L., Long, Y., Szeto, B., Mkuu, R., El-Bassel, N. ( 2018 ). Examining factors associated with unprotected sexual behavior among black Americans postrelease from incarceration in New York City . Journal of Offender Rehabilitation, 57, 330 – 342 .

Google Scholar Crossref | Medline

Safren, S. A., Otto, M. W., Worth, J. L., Salomon, E., Johnson, W., Mayer, K., Boswell, S. ( 2001 ). Two strategies to increase adherence to HIV antiretroviral medication: Life-steps and medication monitoring . Behaviour Research and Therapy, 39, 1151 – 1162 . http://doi.org/10.1016/S0005-7967(00)00091-7

Google Scholar

Sagherian, M. J., Huedo-Medina, T. B., Pellowski, J. A., Eaton, L. A., Johnson, B. T. ( 2016 ). Single-session behavioral interventions for sexual risk reduction: A meta-analysis . Annals of Behavioral Medicine, 50, 920 – 934 . http://doi.org/10.1007/s12160-016-9818-4

Google Scholar

Sanders, S. A., Yarber, W. L., Kaufman, E. L., Crosby, R. A., Graham, C. A., Milhausen, R. R. ( 2012 ). Condom use errors and problems: A global view . Sexual Health, 9, 81 – 95 . http://doi.org/10.1071/SH11095

Google Scholar Crossref | Medline | ISI

Schneider, J., Kaplan, S. H., Greenfield, S., Li, W. J., Wilson, I. B. ( 2004 ). Better physician–patient relationships are associated with higher reported adherence to antiretroviral therapy in patients with HIV infection . Journal of General Internal Medicine, 19, 1096 – 1103 . http://doi.org/10.1111/j.1525-1497.2004.30418.x

Google Scholar

Schneider, J. A., Kozloski, M., Michaels, S., Skaathun, B., Voisin, D., Lancki, N., Morgan, E., Khanna, A., Green, K., Coombs, R. W., Friedman, S. R., Laumann, E., Schumm, P. ( 2017 ). Criminal justice involvement history is associated with better HIV care continuum metrics among a population-based sample of young black men who have sex with men . AIDS, 31, 159 – 165 .

Google Scholar Crossref | Medline

Simoni, J. M., Pantalone, D. W., Plummer, M. D., Huang, B. ( 2007 ). A randomized controlled trial of a peer support intervention targeting antiretroviral medication adherence and depressive symptomatology in HIV-positive men and women . Health Psychology, 26, 488 – 495 . http://doi.org/10.1037/0278-6133.26.4.488

Google Scholar

Sinha, S., McCaul, M. E., Hutton, H. E., Monroe, A. K., Alvanzo, A., Lesko, C., Lau, B., Keruly, J., Moore, R. D., Chander, G. ( 2017 ). Marijuana use and HIV treatment outcomes among PWH receiving care at an urban HIV clinic . Journal of Substance Abuse Treatment, 82, 102 – 106 . http://doi.org/10.1016/j/jsat.2017.09.009

Google Scholar

Springer, S. A., Pesanti, E., Hodges, J., Macura, T., Doros, G., Altice, F. L. ( 2004 ). Effectiveness of antiretroviral therapy among HIV-infected prisoners: Reincarceration and the lack of sustained benefit after release to the community . Clinical Infectious Diseases, 38, 1754 – 1760 . http://doi.org/10.1086/421392

Google Scholar

Springer, S. A., Spaulding, A. C., Meyer, J. P., Altice, F. L. ( 2011 ). Public health implications for adequate transitional care for HIV-infected prisoners: Five essential components . Clinical Infectious Diseases, 53, 469 – 479 . http://doi.org/10.1093/cid/cir446

Google Scholar

Steadman, H. J., Osher, F. C., Robbins, P. C., Case, B., Samuels, S. ( 2009 ). Prevalence of serious mental illness among jail inmates . Psychiatric Services, 60, 761 – 765 .

Google Scholar Crossref | Medline | ISI

Stephenson, B. L., Wohl, D. A., Golin, C. E., Tien, H. C., Stewart, P., Kaplan, A. H. ( 2005 ). Effect of release from prison and re-incarceration on the viral loads of HIV-infected individuals . Public Health Reports, 120, 84 – 88 .

Google Scholar SAGE Journals | ISI

Stephenson, B. L., Wohl, D. A., McKaig, R., Golin, C. E., Shain, L., Adamian, M., Emrick, C., Strauss, R. P., Fogel, C., Kaplan, A. H. ( 2006 ). Sexual behaviours of HIV-seropositive men and women following release from prison . International Journal of STD & AIDS, 17, 103 – 108 . http://doi.org/10.1258/095646206775455775

Google Scholar

Vermeire, E., Hearnshaw, H., Van Royen, P., Denekens, J. ( 2001 ). Patient adherence to treatment: Three decades of research. A comprehensive review . Journal of Clinical Pharmacy and Therapeutics, 26, 331 – 342 . htttp://doi.org/10.1046/j.1365-2710.2001.00363.x

Google Scholar

Walsh, J. C., Mandalia, S., Gazzard, B. G. ( 2002 ). Responses to a 1 month self-report on adherence to antiretroviral therapy are consistent with electronic data and virological treatment outcome . AIDS, 16, 269 – 277 . http://doi.org/10.1097/00002030-200201250-00017

Google Scholar

Wilson, D. P., Law, M. G., Grulich, A. E., Cooper, D. A., Kaldor, J. M. ( 2008 ). Relation between HIV viral load and infectiousness: A model-based analysis . Lancet, 372, 314 – 320 .

Google Scholar Crossref | Medline | ISI

Wohl, D. A., Scheyett, A., Golin, C. E., White, B., Matuszewski, J., Bowling, M., Smith, P., Duffin, F., Rosen, D., Kaplan, A., Earp, J. ( 2011 ). Intensive case management before and after prison release is no more effective than comprehensive pre-release discharge planning in linking HIV-infected prisoners to care: A randomized trial . AIDS and Behavior, 15, 356 – 364 . http://doi.org/10.1007/s10461-010-9843-4

Google Scholar