A fire that has destroyed the Sydney home of Fat Pizza actor Alex Haddad is being treated as suspicious, police have said.

The blaze, which engulfed Haddad's home on Lane Cove Road at Ryde on Monday night, broke out a day after the property was burgled.

Neighbours said they heard a loud explosion and called firefighters about 11:30pm.

When officers arrived the house was well alight but no-one was inside at the time.

On Monday, Mr Haddad's home was broken into and about $80,000 of equipment was stolen, including a saxophone and video cameras.

The actor tweeted that he knew who was responsible.

"To the thief that broke into my house last night, we know who the suspect is. dumb f**ks it will be all be investigated, u will be caught,(sic)" the post said.

He has told police about his suspicions and suggested the suspects may have threatened him before.

Neighbours heard an explosion as fire engulfed Alex Haddad's home at Ryde. ( ABC News )

A police statement said they were treating the fire as suspicious and urged any witnesses to contact them.

Haddad said he believes he has been personally targeted and is now concerned for his safety.

"So, I'm actually standing behind a tree as I'm talking on the main road just in case there'll be a drive-by shooting," he told the ABC.

"I do have a bodyguard at the moment. He'll be with me at public places from now on.

"I got CCTV footage at all my other places and I'm installing alarms and people at my other places are installing CCTV footage as we speak."

The actor has appealed for anyone with information to contact police.

"I really want whoever's done it caught because it is obviously a suspicious fire and it looks like it has been started on purpose"

Specialist forensic teams will be examining the house in a bid to establish the cause of the fire.