Thank you so much for answering this! As a new artist just kinda trying to figure out how to draw, I've found it really hard to figure out some aspects of ponies. :s I think it's because I used to draw back in grade school, but I never drew animals because their snouts and legs always confused me. Switching from human to animal is hard, and then you have anthro, which just amazes me so much!See, I feel like on a fully anthropomorphized pony, like your sketch of Scylla here, it'd be fine to have the cutie mark oriented upward. If they never go on all fours, then it'd never be right-side up! However, if it's just Pinkie Pie being silly, then the cutie mark should logically tilt... I think. It's a little tricky, since actual horses can't go 100% vertical like a Pony can.Again, thank you for answering - I appreciate it! I've never heard anyone talk about this before, and I was a little at a loss. :s I usually never really comment 'cause I'm a little shy, so thank you so much for being so nice! ^^