WASHINGTON — Dina H. Powell, a deputy national security adviser to President Trump and one of the most influential women in the Trump administration, will step down early next year, the White House said on Friday.

Ms. Powell has been involved in an array of foreign policy issues during the last year, including Mr. Trump’s effort to broker a peace accord between Israel and the Palestinians. On the president’s foreign trips, including his most recent to Asia, she regularly had a seat at the table during his meetings with other leaders.

In a White House fractured by tribal divisions, Ms. Powell has been a prominent member of the New York camp affiliated with Mr. Trump’s daughter Ivanka and his son-in-law, Jared Kushner. Her departure will remove one of the figures who has resisted the more hard-line policies advocated by the nationalist wing associated with Stephen K. Bannon, who stepped down over the summer as the president’s chief strategist.

Ms. Powell’s influence extended beyond the national security issues that would normally be under her purview; her name was once floated as a potential White House chief of staff. But her family remained in New York while she worked in Washington, and friends have said the weekly commute, and the time away from her children, had worn on her.