The supplementary material for this article can be found at https://doi.org/10.1017/S0033291719002629 .

We thank the following members of the 23andMe Research Team: Michelle Agee, Babak Alipanahi, Adam Auton, Robert K. Bell, Katarzyna Bryc, Sarah L. Elson, Pierre Fontanillas, Nicholas A. Furlotte, David A. Hinds, Karen E. Huber, Aaron Kleinman, Nadia K. Litterman, Jennifer C. McCreight, Matthew H. McIntyre, Joanna L. Mountain, Elizabeth S. Noblin, Carrie A.M. Northover, Steven J. Pitts, J. Fah Sathirapongsasuti, Olga V. Sazonova, Janie F. Shelton, Suyash Shringarpure, Chao Tian, Joyce Y. Tung, Vladimir Vacic and Catherine H. Wilson.

This work was supported by Wellcome Trust (A.M.Mc., reference 104036/Z/14/Z) (D.M.H., reference 213674/Z/18/Z), the Medical Research Council (A.M.Mc., reference MC_PC_17209) (I.J.D., reference MR/K026992/1), Brain & Behavior Research Foundation (D.M.H., reference 27404), the US National Institute of Mental Health (PGC, references 5 U01MH109528-03) and Age UK (W.D.H., reference Disconnected Mind Project).

Analysis conducted under UK Biobank application 4844. This work has made use of the resources provided by the Edinburgh Compute and Data Facility (ECDF) ( http://www.ecdf.ed.ac.uk/ ).

I.J.D. is a participant in UK Biobank. M.J.A. is a participant in 23andMe Research. Members of the 23andMe Research Team are employees of 23andMe, Inc. The other authors declare no other conflicts of interest.

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