The Senate Republican health care bill would cause an estimated 22 million people to lose their health insurance and lower the federal deficit by $321 billion over the next decade, according to a new analysis from the Congressional Budget Office and the Joint Committee on Taxation.

Senate Republicans carved out their most significant savings in health care spending with $772 billion in cuts to Medicaid, the federal health care program for people in low-income households. Another $408 billion would be slashed in subsidies for individual health insurance plans over the next decade.

The budget office, an independent, non-political entity, paired with the bicameral congressional tax committee to analyze the Senate Republican health care plan. The bill was released last Thursday and GOP leaders are pushing for a final vote this week.

The CBO report reinforced a recent pattern in budget office scores for Republican-backed health care plans aimed at repealing and replacing the Affordable Care Act, also known as Obamacare.

The office said the most recent version of the House bill, which was passed in May, would leave 23 million more people without health insurance by 2026 — 50 million people overall. If the Affordable Care Act remained in place, 28 million people would have no health insurance, the CBO report found. Under the Senate plan, a total of 49 million people would be uninsured within that time frame.

In March the CBO estimated that 24 million people would lose insurance by 2026 under the House’s first health care bill, which was never brought to a vote after House GOP leaders failed to drum up enough support for the measure. The budget office said the plan would have slashed $337 billion in federal dollars by 2026, mostly from reductions in Medicaid and insurance subsidies.

Two months later, on May 24,the office released its analysis of the House’s updated health care bill, which passed narrowly on a party-line 217-213 vote. The CBO found that revisions in the bill lowered federal deficits by $119 billion and left a projected 51 million people uninsured, or 23 million more by 2026 than would be uninsured under the Affordable Care Act.