Hugh Laurie is ready to be a leading man again, as the “House” alum will star in “Chance,” a new drama for Hulu, which landed a 20-episode two-season order, Variety has confirmed.

Based on Kem Nunn’s novel of the same name, “Chance” is described as a provocative psychological thriller that focuses on a forensic neuropsychiatrist who reluctantly gets sucked into a violent and dangerous world of mistaken identity, police corruption and mental illness.

Laurie will star as Eldon Chance, a San Francisco-based forensic neuropsychiatrist. After an ill-advised decision regarding an alluring patient who may be struggling with a multiple personality disorder, he finds himself in the crosshairs of her abusive spouse who also happens to be a ruthless police detective. In over his head, Chance’s descent into the city’s shadowy underbelly, all while navigating the waters of a contentious divorce and the tribulations of his teenage daughter, soon spirals into an ever deepening exploration of one of mankind’s final frontiers — the shadowy, undiscovered country of the human mind.

Hailing from Fox 21 Studios, the project, first reported by Deadline, is jam-packed with Lenny Abrahamson, hot off his Oscar-contender “Room,” attached as an exec producer and director for several episodes, plus Alexandra Cunningham (“Desperate Housewives”), Michael London (“Milk,” “Trumbo”) and Brian Grazer (“Empire”) all serving as exec producers. Laurie and Nunn will also exec produce.

The project marks the first series to land at a streaming service for Fox 21, which is currently behind Showtime’s “Homeland,” WGN America’s “Salem,” and FX’s “Tyrant,” “The Americans” and “Sex&Drugs&Rock&Roll.” Fox 21 is also producing FX’s hotly anticipated O.J. Simpson series, “American Crime Story.”

“Chance” is a big move for Hulu, which is amping up its slate of original content. Up next is James Franco’s “11.22.63,” which debuts Feb. 15, and also “The Path” from Jason Katims, which stars “Breaking Bad” alum Aaron Paul.

Nunn, Laurie, Abramson, Cunningham and London are all repped by WME. Abrahamson is also repped by Rachel Holroyd from Casarotto Ramsay and Laurie is repped by Christian Hodell from Hamilton Hodell.

“Chance” is slated for a 2016 launch.