More than 60 hand guns and a quantity of ammunition has been stolen from a commercial building in Perth's south-eastern suburbs.

Regional Investigation Unit detectives are investigating the burglary on the commercial premises in Clapham Street, Beckenham.

More than 60 handguns have been stolen in a burglary over the weekend. Credit:iStock

The burglary happened between 10:20pm on Saturday and 2:50am on Sunday.

Police say the offenders broke into the business and stole more than 60 hand guns and ammunition.

Police want anyone with information about the incident or knows someone who is in possession of a large amount of hand guns to contact police immediately on 131 444.

Information can also be passed onto Crime Stoppers on 1800 333 000 or online at crimestopperswa.com.au