House Speaker John Boehner's abrupt resignation Friday -- after an insurrection by grassroots activists infuriated at the failure of Washington Republicans to thwart President Barack Obama -- was another bad omen for a campaign wilting amid anti-establishment fury.

In the 2016 presidential race, outsiders are in, insiders are out and the messy power struggle that is splintering the GOP is going to make winning the nomination -- and then capturing the White House -- very tough for a party standard bearer like Bush.

Donald Trump, Ben Carson and Carly Fiorina are dominating the GOP presidential primary following a summer of anger powered by conservative activists, Tea Party agitators and talk radio provocateurs. Candidates like Bush, New Jersey Gov. Chris Christie and Ohio Gov. John Kasich, meanwhile, have been overtaken by events, with the traditional GOP path to the nomination blocked by scorched earth insurgents.

Boehner, R-Ohio, holds a copy of the Constitution on Capitol Hill in Washington on May 7, 1992, as Sen. Don Nickles, D-Oklahoma, looks on. Both men proclaimed it was a historic day when the Michigan House ratified the 27th Amendment to the Constitution, which would require that any Congressional pay raises not go into effect until after the next election.

Boehner, R-Ohio, holds a copy of the Constitution on Capitol Hill in Washington on May 7, 1992, as Sen. Don Nickles, D-Oklahoma, looks on. Both men proclaimed it was a historic day when the Michigan House ratified the 27th Amendment to the Constitution, which would require that any Congressional pay raises not go into effect until after the next election.

Boehner at a Capitol Hill news conference on February 6, 1995. He has had a seat in the U.S. House of Representatives since 1990. Before that he was a member of the Ohio State House of Representatives for six years.

Boehner at a Capitol Hill news conference on February 6, 1995. He has had a seat in the U.S. House of Representatives since 1990. Before that he was a member of the Ohio State House of Representatives for six years.

Boehner dumps out coal, which he called a Christmas gift to President Clinton, during a news conference about the federal budget on December 21, 1995. Many government services and agencies were closed at the end of 1995 and beginning of 1996 as a Republican-led Congress battled Clinton over spending levels.

Boehner dumps out coal, which he called a Christmas gift to President Clinton, during a news conference about the federal budget on December 21, 1995. Many government services and agencies were closed at the end of 1995 and beginning of 1996 as a Republican-led Congress battled Clinton over spending levels.

President George W. Bush signs into law the federal education bill No Child Left Behind at a high school in Hamilton, Ohio, in 2002. The law offered the promise of improved schools for the nation's poor and minority children and better-prepared students in a competitive world. Boehner, second from right, backed the bill.

President George W. Bush signs into law the federal education bill No Child Left Behind at a high school in Hamilton, Ohio, in 2002. The law offered the promise of improved schools for the nation's poor and minority children and better-prepared students in a competitive world. Boehner, second from right, backed the bill.

Boehner, center, and fellow Republican House members sing Boehner's birthday song during a news conference on Capitol Hill on November 17, 2006. Boehner served as the House Minority Leader from 2007 to 2011.

Boehner, center, and fellow Republican House members sing Boehner's birthday song during a news conference on Capitol Hill on November 17, 2006. Boehner served as the House Minority Leader from 2007 to 2011.

Boehner, center, looks on as President Barack Obama speaks with then-House Majority Leader Steny Hoyer in the East Room of the White House on February 23, 2009. Boehner and Obama have butted heads over the years.

Boehner, center, looks on as President Barack Obama speaks with then-House Majority Leader Steny Hoyer in the East Room of the White House on February 23, 2009. Boehner and Obama have butted heads over the years.

Boehner, an avid golfer, talks with Tiger Woods while golfing at the Congressional Country Club in Bethesda, Maryland, in 2009.

Boehner, an avid golfer, talks with Tiger Woods while golfing at the Congressional Country Club in Bethesda, Maryland, in 2009.

Boehner voices his concerns about the health care reform bill championed by Obama during a news conference in Washington on October 29, 2009.

Boehner voices his concerns about the health care reform bill championed by Obama during a news conference in Washington on October 29, 2009.

Boehner hugs his wife, Debbie, after addressing the crowd at the NRCC Election Night watch party on November 2, 2010, when Republicans took back control of the House of Representatives. Boehner met his wife in college, and they have been married since 1973.

Boehner hugs his wife, Debbie, after addressing the crowd at the NRCC Election Night watch party on November 2, 2010, when Republicans took back control of the House of Representatives. Boehner met his wife in college, and they have been married since 1973.

On January 5, 2011, Boehner wipes away tears as he waits to receive the gavel from outgoing House Speaker Nancy Pelosi, D-California, during the first session of the 112th Congress.

On January 5, 2011, Boehner wipes away tears as he waits to receive the gavel from outgoing House Speaker Nancy Pelosi, D-California, during the first session of the 112th Congress.

Boehner presents golfing legend Arnold Palmer with the Congressional Gold Medal at a special ceremony in the Rotunda of the Capitol in September 2012.

Boehner presents golfing legend Arnold Palmer with the Congressional Gold Medal at a special ceremony in the Rotunda of the Capitol in September 2012.

Boehner is sworn in as the speaker of the House after his re-election in January 2013.

Boehner is sworn in as the speaker of the House after his re-election in January 2013.

Boehner speaks to the media after a meeting with President Obama at the White House in October 2013, the second day of the federal government's recent shutdown. The White House squared off with Republican rivals in Congress over how to fund federal agencies, many of which were forced to close, leaving a fragile economy at risk.

Boehner speaks to the media after a meeting with President Obama at the White House in October 2013, the second day of the federal government's recent shutdown. The White House squared off with Republican rivals in Congress over how to fund federal agencies, many of which were forced to close, leaving a fragile economy at risk.

Reporters question Boehner as he arrives at the U.S. Capitol as the government stalemate continued in October 2013. President Obama signed a bill on October 17 that ended the 16-day shutdown and raised the debt ceiling.

Reporters question Boehner as he arrives at the U.S. Capitol as the government stalemate continued in October 2013. President Obama signed a bill on October 17 that ended the 16-day shutdown and raised the debt ceiling.

Boehner blasts conservative groups during a press conference in December 2013 after passing a compromise budget deal aimed at removing the threat of another government shutdown. Fed up with criticism from conservative advocates, Boehner said they were "misleading their followers." He followed up with: "Frankly, I just think that they've lost all credibility."

Boehner blasts conservative groups during a press conference in December 2013 after passing a compromise budget deal aimed at removing the threat of another government shutdown. Fed up with criticism from conservative advocates, Boehner said they were "misleading their followers." He followed up with: "Frankly, I just think that they've lost all credibility."

The image of the Speaker of the House John Boehner (R-OH) is displayed in a monitor of a camera as he talks with reporters in his office in the Capitol in November 2014 in Washington.

The image of the Speaker of the House John Boehner (R-OH) is displayed in a monitor of a camera as he talks with reporters in his office in the Capitol in November 2014 in Washington.

U.S. Vice President Joe Biden and Speaker of the House John Boehner await the arrival of President Barack Obama for the State of The Union address on January 20 in the House Chamber of the Capitol.

U.S. Vice President Joe Biden and Speaker of the House John Boehner await the arrival of President Barack Obama for the State of The Union address on January 20 in the House Chamber of the Capitol.

U.S. President Barack Obama walks with Speaker of the House John Boehner as they depart the annual Friend's of Ireland luncheon on Capitol Hill in Washington on March 17.

U.S. President Barack Obama walks with Speaker of the House John Boehner as they depart the annual Friend's of Ireland luncheon on Capitol Hill in Washington on March 17.

Afghanistan President Ashraf Ghani (right) expresses his country's gratitude for America's fiscal commitment and military sacrifices during an address to a joint meeting of the United States Congress with Vice President Joe Biden (left) and Speaker of the House John Boehner (R-OH) in the House Chamber of the U.S. Capitol March 25 in Washington.

Afghanistan President Ashraf Ghani (right) expresses his country's gratitude for America's fiscal commitment and military sacrifices during an address to a joint meeting of the United States Congress with Vice President Joe Biden (left) and Speaker of the House John Boehner (R-OH) in the House Chamber of the U.S. Capitol March 25 in Washington.

John Boehner has been the speaker of the U.S. House of Representatives since 2011, making him second in line for the presidency, behind the vice president. On September 25, Boehner told colleagues he's stepping down as speaker and will leave Congress at the end of October. Look back at his career in politics so far.

John Boehner has been the speaker of the U.S. House of Representatives since 2011, making him second in line for the presidency, behind the vice president. On September 25, Boehner told colleagues he's stepping down as speaker and will leave Congress at the end of October. Look back at his career in politics so far.

Boehner's departure might be the conservative right's most famous get yet -- even bigger than the coup against his former lieutenant Eric Cantor in a primary election in 2014. And the reaction to his resignation crystallized the split in the GOP with conservatives emboldened and establishment candidates sounding a softer tone that seems increasingly out of step with primary voters.

"You want to know how much each of you terrify Washington?" asked Sen. Ted Cruz, a GOP presidential candidate and self-styled scourge of Washington asked right-leaning activists at the Values Voter Summit in Washington on Friday. "Yesterday John Boehner was Speaker of the House. Y'all come to town and somehow that changes. My only request is can you come more often!"

Conservative groups aligned with the Tea Party and the House Freedom Caucus were quick to claim that Boehner's decision showed they had defeated the more moderate elements of the party. Citizen's United President David Bosse declared that Boehner's exit was a "victory for grassroots conservatives."

FreedomWorks CEO Adam Brandon linked the Cantor and Boehner ousters and proclaimed: "the tide is changing in Washington." He pledged the group would force the next set of House leaders to "adhere to conservative principles."

Trump, who is positioning himself as the ultimate outsider and galvanizing grassroots conservatives to power his anti-establishment crusade, said Boehner's announcement showed that it was time "to get back to business."

'Get it done'

"We want people that are going to get it done," he said addressing Boehner's decision at the Washington summit where he arrived carrying his Bible. "They get elected. They're full of vim and vigor. They're going to change things... They come down to these magnificent vaulted ceilings that you see all over Washington. And what happens? They become different people."

For his part, Bush simply took to Twitter to praise Boehner's career.

"John Boehner dedicated his life to public service. Bringing the Holy Father to Congress was a fitting cap to a great career," Bush said, referring to Pope Francis accepting an invitation from Boehner to speak before lawmakers on Thursday.

It would be impossible to overestimate the strength of antipathy toward Boehner and his Senate counterpart, Republican Majority Leader Mitch McConnell, among the kind of people that show up to Trump's events in places like Alabama and Dallas. These potential voters believe that the party's leaders have ignored them and squandered victories the party was handed in the 2010 and 2014 mid-term elections that led to a GOP majority on Capitol Hill.

Despite the constitutional constraints on action in Washington and the presence of a Democratic President with a veto in the White House, they are furious that the GOP has failed to overturn Obamacare.

The same struggle is now playing out among grassroots activists who want to shut down the government in a bid to defund Planned Parenthood -- pitting them against party leaders who believe they must show voters they can govern before the 2016 presidential race.

Shortly after Boehner's announcement on Friday morning, Ken Cuccinelli, who runs the Senate Conservatives Fund, sent an email to his membership list with the title "You Did It."

"All of your efforts have brought us to this point, and we're extremely grateful. To save this great country, we need strong Republican leaders who will stand up for our conservative principles and not back down."

Former Cantor aide Doug Heye, paraphrasing late New York Yankees hero Yogi Berra who died this week, said Boehner's departure left the GOP with a dilemma.

'Fork in the road'

"Republicans are coming to a fork in the road -- and the question is -- whether or not they will take it," Heye told CNN. "There are a lot of people who wanted to fight -- all we could do is fight Obama, fight the Democrats nonstop. Or do we have a strategy of not just throwing punches but landing punches?"

The way the GOP resolves that question could go a long way to sealing the fate of Bush and other Republican establishment candidates and answer another question hanging over the 2016 race: will the GOP nominate a candidate with broad enough appeal to win a general election?

For months, the argument for Bush's candidacy has been that he would be the most electable candidate, having shown his ability to win in the mighty swing state of Florida. But for now, at least among the activists who dominate the early caucus and primary states, the premium is on desire for something fresh.

A track record of compromise and the ability to work seamlessly with both sides of the aisle is increasingly looking like a blemish on the records of establishment candidates like Bush rather than an asset.

In recent election cycles, even those in which outsiders, for a short time at least captured the zeitgeist, the GOP has eventually returned to establishment figures like Mitt Romney and John McCain.

For Bush to win in 2016, that would have to happen again. But so far, as he lags below 10% in many national polls and struggles for traction in swing states, that is not happening.

And if GOP Rep. Peter King of New York is right, it may already be too late for the establishment to prevail.

King said Boehner's departure was essentially "throwing raw meat" to "small but loud faction" of the GOP and was bad news for the party.

"It signals that crazies have taken over the party," King told CNN. "This has never happened before in our country. Where a person doing a job, the Speaker of the house, was removed from office, by a small faction because they want these unreasonable demands that if you don't agree with them you shut the government down. This is insanity."

One candidate left with a delicate balancing act after Boehner's demise is Florida Sen. Marco Rubio, currently enjoying a polling spurt after a strong showing in the CNN GOP debate earlier this month.

Rubio, a former Florida House speaker, is simultaneously angling for the establishment lane of the party -- trying to elbow out his mentor Bush -- while seeking to retain credibility with the right. His delicate task was summed up in his reaction to Boehner's resignation -- news of which came through as he was on stage for the Values Voter Summit.

"I'm not here to bash anyone --- but the time has come to turn the page. The time has come to turn the page and allow a new generation of leadership in this country," Rubio said.

At the risk of angering far-right activists, Kasich went the farthest among the presidential candidates in supporting Boehner on Friday.

'Dysfunction'

"It just reflects the dysfunction in Washington," Kasich said. "Where people cannot even honor somebody who has dedicated their life to public service... He built the largest Republican majority in modern time... I guess no good deed goes undone or unpunished because some of the most savage attacks on him come from Republicans."

Watching the Republican infighting from the sidelines, many Democratic strategists view the increasing pressure on GOP candidates to appease the far right as a harbinger of good things to come for their party in 2016.

Democratic pollster Geoff Garin, the president of Hart Research -- a firm that has done recent polling for the Planned Parenthood Action Fund -- said Friday's developments raised serious questions about "whether the Republican Party can survive as a coherent, functioning political entity."

"Since Republicans have become the majority party in the House, their brand has really been severely damaged," Garin said. "It's not that people necessarily love the Democratic Party or have a very high regard for it," but Republicans, Garin said, "have alienated huge swaths of the electorate, particularly millennials and important groups of women voters."

Pointing to his firm's polling for Planned Parenthood Action Fund earlier this summer, Garin argued the brinksmanship over shutting down the government in a futile effort to defund Planned Parenthood has not done the Republican Party any favors.

While the unrest within the GOP may continue to push the presidential candidates farther to the right, several Republican strategists cautioned that the most electable candidate often prevails. And in the long run, Boehner's departure may have little impact on the presidential race — beyond being a symbol of division within the GOP.

Veteran Republican strategist Kevin Madden said Boehner may have served as an applause line for some of the candidates Friday, but that "voters aren't going to be making their decision on our next nominee through the lens of a House leadership figure."

"The more important question for each candidate," he said, "is whether you can persuade voters that you have the unique ability to lead the country and can be an effective commander in chief. You have to answer that on your own, no matter who the Speaker of the House is."