She's the new star of HBO's female-focused show Big Little Lies.

And despite joining the hit program based on women's oftentimes unseen struggles, Meryl Streep admitted that she doesn't necessarily agree with the term 'toxic masculinity' during a sit down with Vanity Fair.

The 69-year-old actress addressed the term — which defines the harmful effects of masculine behaviors associated with violence, emotional instability and sexual aggression — during a discussion about male fans of the drama.

Discussion: Despite joining the hit program based on women's oftentimes unseen struggles, Meryl Streep admitted that she doesn't necessarily agree with the term 'toxic masculinity' during a sit down with Vanity Fair; seen on Wednesday

The Mamma Mia star insisted that she doesn't agree with the label as it's not just men who can be harmful to society, and thinks women can 'be pretty f****g toxic' too.

'Sometimes, I think we're hurt. We hurt our boys by calling something toxic masculinity. I do,' she told Vanity Fair editor Radhika Jones.

'And I don't find putting those two words together [works] because women can be pretty f***ng toxic. It's toxic people. We have our good angles and we have our bad ones.'

Interesting: The 69-year-old actress addressed the term — which defines the harmful effects of masculine behaviors associated with violence, emotional instability and sexual aggression — during a discussion about male fans of the drama; seen on Wednesday

The Devil Wears Prada star went on to suggest that 'communication' is the way to improve relationships between 'human beings' regardless of gender.

'I think the labels are less helpful than what we're trying to get to, which is a communication, direct, between human beings,' she said. 'We're all in the boat together. We've got to make it work.'

Meryl was joined at the event by co-stars Reese Witherspoon, Laura Dern and Nicole Kidman and added that she's a huge admirer of cast member Shailene Woodley, who wasn't in attendance.

Streep is pictured playing her iconic role of a 'toxic' boss in The Devil Wears Prada

Flower power: Streep stepped out onto the blue carpet wearing an Oscar de la Renta gown for Big Little Lies premiere in New York on Wednesday night

'Shailene is just a miracle in this,' she said. 'I have to say. I'm glad she's not here because I can talk about her. I mean, she's a miracle.

'She's so ... open to the role. She did a film called Adrift this year, which I don't know if anybody saw, because of course they didn't promote it.'

Streep stepped out onto the blue carpet wearing an Oscar de la Renta gown for Big Little Lies premiere in New York on Wednesday night.

She joins the cast in season two as the mother-in-law of Nicole Kidman's character, whose husband Perry, played by Alexander Skarsgaard, was killed in the season one finale.