THIS STORY IS UPDATED HERE: Hurricane Irma: Flight cancellations begin in Florida

ORIGINAL POST: Airlines have been forced to shift their attention to Hurricane Irma just two weeks after Hurricane Harvey snarled flights in Texas, leaving nearly 13,000 cancellations in its wake there.

Now, it’s Irma that threatened to make a mess of U.S. flight schedules as it roars toward Florida as a Category 5 storm.

Florida’s Key West International Airport has said it will suspend all flights starting at 5:50 p.m. local time on Wednesday evening. The airport said it would remain closed indefinitely.

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Nearly all big U.S. airlines were waiving change fees, with a number of Florida airports added to those rebooking waivers on Tuesday.

American, which operates one of its busiest hubs in Miami, included that airport among the 33 for which eligible customers can change their flight plans at no charge. Delta, JetBlue, Southwest, Spirit and United were among other big airlines also waiving rebooking charges for some Florida airports.

Flights across the Caribbean have already been grounded there as Irma roars across the region. Flight-tracking service FlightAware counted 30 airports in the region that were either closed or affected by Irma-related cancellations as of mid-day Wednesday.

More than 160 flights were canceled at the Luis Munoz Marin International Airport in San Juan, Puerto Rico – one of the busiest hubs in the region. At the Princess Juliana International Airport in Saint Martin – another of the region’s busier hubs – about 60 flights were grounded, according to FlightAware, and more were likely.

Many other airports – including some in Puerto Rico and the Virgin Islands – were seeing widespread cancellations Wednesday. As elsewhere in the region, cancellation totals are likely to grow in the coming days.

Flights to airports immediately in Irma’s path – such as those on Antigua and Barbuda – closed Tuesday and would likely remain closed for days after they were hit by the storm.

Beyond Wednesday, cancellations were spilling into Thursday and Friday, too. More than 100 flights, for example, had already been grounded in San Juan for Thursday. Fliers traveling to the region should expect widespread disruptions for at least the next week.

Overall, air travelers this week should stay on top of Irma’s track and be prepared for disruptions not in the Caribbean, but also in Florida. By the weekend, the storm appeared likely to affect South Florida and the Bahamas, though the precise track remained uncertain.

