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Thirteen MPs and MEPs from three parties have come together to demand a second Brexit referendum.

The signatories have penned an open letter to the Mirror calling for a “people’s vote” on any final deal with Brussels secured by Theresa May.

The authors - all politicians from the south of England - include Labour former Cabinet Minister Ben Bradshaw, Lib Dem education spokeswoman Layla Moran and Green MP Caroline Lucas.

The letter says: “Brexit is a big deal.

(Image: PA)

“That’s why we think it should be handed back to the people to have a final say.”

The intervention comes after Tory former Cabinet Minister Justine Greening last month called for a fresh referendum and amid resurgent efforts by Remainers to derail Brexit.

They believe the 52% to 48% victory for the Leave campaign at the June 2016 referendum - the largest democratic exercise ever seen in Britain and which saw a 1.2 million majority wanting to quit the bloc - could now be overturned.

A second poll would fuel claims a pro-EU elite was failing to respect the result of the original poll, and risk alienating swathes of the electorate.

No 10 has repeatedly ruled out a fresh referendum.

But the signatories insist they are not trying to rerun the poll from two years ago.

Their letter says: “We have a duty to secure the best possible future for our constituents and their families.

“Unfortunately, we believe that the Brexit deal being negotiated by the Government represents a serious threat to that future.

(Image: Getty Images Europe) (Image: PA) (Image: PA)

“The Government’s own economic analysis shows the UK will be very badly hit if we leave the EU Single Market and Customs Union.

“Businesses across the south, both large and small, rely heavily on unhindered access to the European market and the deeply integrated supply chains that now criss-cross the EU.

“Companies such as BMW, Airbus and Honda, who employ thousands of people and whose supply chain includes thousands more, have already raised serious concerns about what a hard Brexit will mean for the future of their operations in the UK.

“It has become increasingly clear that Brexit will fail to deliver what the leaders of the Leave campaign promised.

“Extra funding for the NHS, ending payments to Brussels, new free-trade deals and numerous other promises have been exposed as fantasies.

“And as new information on the impacts of Brexit – not just economic, but also social and environmental – come to light, calls are growing louder for a People’s Vote on the final Brexit deal.

(Image: PA) (Image: AFP)

“Let’s be clear: this isn’t about re-running the 2016 referendum. The result was a narrow vote in favour of leaving the EU.

“But this does not give the Government a mandate to force a bad Brexit deal on people in this country.

“If we allowed that to happen without consulting our constituents, we wouldn’t be representing their best interests.”

It is signed by:

Ben Bradshaw, Labour MP for Exeter

Caroline Lucas, Green Party MP for Brighton Pavilion

Catherine Bearder, Liberal Democrat MEP for South East England

Clare Moody, Labour MEP for South West England

Darren Jones, Labour MP for Bristol North West

John Howarth, Labour MEP for South East England

Julie Girling, Independent MEP for South West England

Keith Taylor, Green Party MEP for South East England

Layla Moran, Liberal Democrat MP for Oxford West and Abingdon

Molly Scott Cato, Green Party MEP for South West England

Peter Kyle, Labour MP for Hove and Portslade

Rosie Duffield, Labour MP for Canterbury