A revolutionary new in vitro fertilisation (IVF) treatment is helping South Australian women become pregnant.

Researchers in Australia and Japan said the technology could give new hope to women who previously struggled to achieve a pregnancy using IVF.

Adelaide couple Sarah Siakew and Shane Murphy have tried IVF eight times and were on the verge of giving up when offered a place in a trial program.

"This was our last go — we had tried for many, many years. I took some long service leave from work last year, we went on a trip to Europe, bought a new house and we thought we'd just give it one more go," Ms Siakew said.

"We were very lucky that it worked, so [we are] very happy."

The technology known as BlastGen was developed by Adelaide University, and seven of 16 women who used the treatment became pregnant, researcher Louise Hull said.

"[To] do something that hopefully improves their embryos and hopefully gives them a chance at an ongoing pregnancy is, you know, that's why we do it," she said.

Molecule in uterus is the key

Professor Hull said the treatment, being used in Adelaide and Japan, uses a naturally occurring "signalling" molecule in the uterus to help develop embryos, which are cultured for longer than otherwise before implantation.

"We certainly are finding that the benefits for some couples in terms of embryo quality are quite dramatic," she said.

"Certainly our pregnancy rates for couples that have had lots and lots of treatment often have been really quite high.

"The embryo is being cultured in an environment that closely mimics what occurs naturally in a mother during conception [and] as a result the embryos grow in a more natural environment than they do in traditional IVF treatments."

Dale and Mel Rogers now have three boys. ( ABC News )

Up to 100 women who have had failed IVF attempts or miscarriages will be part of the trial.

Among those already delighted with its results are Mel and Dale Rogers, who went from childless to having three boys.

"We were lucky enough that we could have Darcy, and to be able to have twins after having Darcy is just a miracle," Ms Rogers said.

The trial is expected to continue for another 18 months and it is hoped the treatment will then become commercially available to more couples.

Couples trying IVF where the female is aged between 25 and 41, and where there have been at least two embryo transfers without implantation, poor embryo development or at least one miscarriage, are able to seek involvement in the trial and can contact Fertility SA on 8100 2900 for more details.