Stem cell therapies

Defects in HSCs lead to various blood-related disorders and cancers that are partly treated by HSC transplantations. The controlled production of bona fide HSCs from pluripotent precursors remains very difficult to achieve in vitro, in a petri dish, and therefore requires a better understanding of the HSC production as it occurs physiologically in vivo, in the living body. Identifying all steps of hematopoietic production and the molecular events controlling this process is of fundamental interest and should help to devise innovative stem cell therapies for hematopoietic disorders in the future.

Publication

In vivo generation of haematopoietic stem/progenitor cells from bone marrow-derived haemogenic endothelium. Laurent Yvernogeau, Rodolphe Gautier, Laurence Petit, Hanane Khoury, Frédéric Relaix, Vanessa Ribes, Helen Sang, Pierre Charbord, Michèle Souyri, Catherine Robin and Thierry Jaffredo. Nature Cell Biology 2019.