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ODE-Bn-PMEG abolishes human papillomavirus productive infection in 3D cultures of primary human keratinocytes (PHKs).

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Incorporation of activated ODE-Bn-PMEG into replicating DNA causes DNA breaks and abolishes viral activities.

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ODE-Bn-PMEG induces apoptosis selectively in HPV-infected, differentiated keratinocytes while sparing uninfected tissues.

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Cidofovir, which is used to treat human cytomegalovirus retinitis, neither induces apoptosis nor abolishes HPV activity.

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