1 / 48 Lana Wachowski

Award-winning filmmaker <a href="http://www.imdb.com/name/nm0905154/">Lana Wachowski</a>, who's best known for co-writing and -directing the "Matrix" trilogy with her brother, Andy Wachowski, was the first major Hollywood director to come out as transgender in July 2012. The Chicago native recently released "Cloud Atlas" and <a href="https://www.huffpost.com/entry/lana-wachowski-transgender-cloud-atlas-director-reveals-pain-suicide-attempt_n_2009112">received the Human Rights Campaign's Visibility Award</a> in October 2012, where she delivered a revealing and heartfelt speech.

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