Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellFEC flags McConnell campaign over suspected accounting errors Poll: 59 percent think president elected in November should name next Supreme Court justice Mark Kelly: Arizona Senate race winner should be sworn in 'promptly' MORE (R-Ky.) said Wednesday that the Senate will vote in the fall to confirm President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE's forthcoming nominee to replace Supreme Court Justice Anthony Kennedy.

"The Senate stands ready to fulfill its constitutional role by offering advice and consent … We will vote to confirm Justice Kennedy’s successor this fall," McConnell said from the Senate floor.

Kennedy announced on Wednesday afternoon that he is retiring after more than 30 years on the court, kicking off what is sure to be a vicious confirmation battle in the lead-up to the midterm elections.

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Trump, who said he spoke with Kennedy for about half an hour at the White House on Wednesday afternoon, told reporters that the search for Kennedy's successor will begin "immediately."

McConnell laid down early guidelines for consideration of the forthcoming nomination, saying while senators would be able to meet with the nominee, he expected Trump's pick to be treated "fairly."

"It's imperative that the president's nominee be considered fairly and not subjected to personal attacks," McConnell added.

Democrats will face intense pressure to use every procedural tool to stall and slow-walk Trump's pick.

But Republicans went "nuclear" and got rid of the 60-vote procedural hurdle when they confirmed Trump's first Supreme Court nominee, Justice Neil Gorsuch, meaning Democrats can't block Trump's forthcoming pick without help from Republicans.

Republicans have a slim 51-seat majority. With Sen. John McCain John Sidney McCainThe Memo: Trump's strengths complicate election picture Mark Kelly: Arizona Senate race winner should be sworn in 'promptly' Cindy McCain: Trump allegedly calling war dead 'losers' was 'pretty much' last straw before Biden endorsement MORE (R-Ariz.) battling brain cancer, their caucus is effectively capped at 50 votes.

That means Democrats would need to win over at least one GOP senator — as well as keep their caucus united — if they wanted to be able to sink Trump's Supreme Court nominee.

Democratic Sens. Joe Manchin (W.Va.), Heidi Heitkamp Mary (Heidi) Kathryn HeitkampHarris faces pivotal moment with Supreme Court battle Centrists, progressives rally around Harris pick for VP 70 former senators propose bipartisan caucus for incumbents MORE (N.D.) and Joe Donnelly Joseph (Joe) Simon DonnellyHarris faces pivotal moment with Supreme Court battle Trump meets with potential Supreme Court pick Amy Coney Barrett at White House Names to watch as Trump picks Ginsburg replacement on Supreme Court MORE (Ind.) — who are each up for reelection this year in states won by Trump in 2016 — voted for Gorsuch last year.