Struggling NBC is clearly the network that needs the biggest fall overhaul. But CBS , it turns out, is the network going into the 2010-11 season with the most radically altered lineup.

In a surprising move, CBS announced yesterday that it will move the hit sitcom “The Big Bang Theory’’ from Mondays to Thursdays at 8 p.m. Going up against NBC’s critically praised but modestly rated “Community’’ and “30 Rock,’’ “Big Bang’’ will be followed by “Bleep My Dad Says’’ starring William Shatner at 8:30 p.m. “Bleep’’ is based on writer Justin Halpern’s Twitter feed about his father’s more colorful comments.

Also surprising from CBS: “CSI: Miami’’ will move to Sundays, “CSI: NY’’ will move to Fridays, and “Survivor’’ will move to Wednesdays. Meanwhile, “The New Adventures of Old Christine,’’ “Ghost Whisperer,’’ and “Gary Unmarried’’ won’t be moving anywhere. They’ve been canceled. The same for “Miami Medical,’’ “Numb3rs,’’ “Accidentally on Purpose’’ and “Cold Case.’’

CBS’s list of new shows includes a “Hawaii 5-0’’ remake with Daniel Dae Kim from “Lost’’ and Alex O’Loughlin, as well as “Blue Bloods’’ with Tom Selleck. “Blue Bloods’’ also features two Massachusetts natives, Donnie Wahlberg and Bridget Moynahan, which must be why the family cop drama is set in New York. CBS’s promised “Criminal Minds’’ spinoff featuring Forest Whitaker has been scheduled for midseason.

Next to CBS’s aggressive changes, ABC looks like more of a Sleepy Sally. It has canceled “FlashForward,’’ “Better Off Ted,’’ “Romantically Challenged,’’ and “Scrubs.’’ Its list of new shows includes “No Ordinary Family,’’ with Michael Chiklis as part of a family with superpowers, and “Detroit 1-8-7,’’ with Michael Imperioli from “The Sopranos’’ as a homicide detective. The comedy “Mr. Sunshine,’’ starring Matthew Perry as a guy in a midlife crisis, is due midseason.

Also due midseason: “Off the Map,’’ yet another ensemble medical drama from Shonda Rhimes of “Grey’s Anatomy’’ and “Private Practice.’’ Just what the ratings doctor ordered.

Matthew Gilbert can be reached at gilbert@globe.com. For more on TV, visit www.boston.com/ae/tv/blog.

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