President Trump early Wednesday targeted Republican Sen. Lisa Murkowski Lisa Ann MurkowskiGraham: GOP will confirm Trump's Supreme Court nominee before the election Gardner signals support for taking up Supreme Court nominee this year Tumultuous court battle upends fight for Senate MORE (Alaska) after her votes a day earlier on healthcare.

"Senator @lisamurkowski of the Great State of Alaska really let the Republicans, and our country, down yesterday," Trump tweeted.

"Too bad!"

Senator @lisamurkowski of the Great State of Alaska really let the Republicans, and our country, down yesterday. Too bad! — Donald J. Trump (@realDonaldTrump) July 26, 2017

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Murkowski on Tuesday joined senate Democrats in voting against a procedural measure to begin debate on healthcare legislation.

She and Sen. Susan Collins Susan Margaret CollinsGraham: GOP will confirm Trump's Supreme Court nominee before the election Gardner signals support for taking up Supreme Court nominee this year Tumultuous court battle upends fight for Senate MORE (R-Maine) voted against the measure, which passed by a razor-thin margin and marked a step forward in the Republicans' efforts to repeal and replace ObamaCare.

Murkowski also voted against a key proposal repealing and replacing ObamaCare later in the day.

Senators voted 43-57 on a procedural hurdle for the measure that included the GOP repeal-and-replace bill, the Better Care Reconciliation Act, as well as proposals from GOP Sens. Ted Cruz (Texas) and Rob Portman (Ohio).

Murkowski joined several other GOP senators in rejecting the proposal.