Located west of Rice University, West University has the cities of Bellaire to the west, Southside Place to the south, and Houston to the north and east.

The Museum District and the Texas Medical Center lie further west of the city.

Several main roads go through the city, including the Buffalo Speedway, Bellaire Boulevard, Bissonnet Street, and Kirby Drive. Loop 610 and US 59 (Southwest Freeway) are minutes away from West University.

The city has remained a quiet residential enclave over the years, thanks to its deed restrictions and zoning ordinances.

West University is within the 77005 zip code of Harris County.

Zip codes near West University TX include 77046, 77030, 77025, and 77401. (View Houston zip code map.)