At least 58 people have been killed after a "lone wolf" gunman opened fire at crowds at a Las Vegas music festival from a hotel window.

At least 500 others were injured as Stephen Paddock, 64, sprayed bullets at the Route 91 Harvest event with an automatic weapon from the nearby Mandalay Bay Hotel and Casino.

He killed himself before police entered his room, where officers found more than 10 firearms.

Here's a timeline of how the deadliest shooting in American history unfolded.

9.40pm local time (5.40am BST)

Country music star Jason Aldean takes to the stage for his set at the Route 91 Harvest music festival, an outdoor event on the Las Vegas Strip. More than 22,000 people are at the sold-out concert.

Las Vegas Metropolitan Police in front of a sign for the Route 91 Harvest festival (EPA)

10.08pm

Gunman with an automatic weapon opens fire on festival crowds. Concert-goers flee in terror and hide behind barriers, food stalls and cars as hail of bullets rains down from nearby hotel. Some attendees are trampled on as panicked crowds attempt to escape.

10.38pm

Las Vegas police confirm they are "investigating reports of an active shooter" near to Mandalay Bay Hotel and Casino. They urge people to avoid the area.

11pm

Police shut parts of Las Vegas Boulevard, a major road famous for its strip of casinos, and place the area on lockdown.

11.15pm

University Medical Centre in Las Vegas says it is treating "several" people with gunshot wounds.

11.30pm

McCarran International Airport, two miles from the scene of the shooting, says it has grounded planes and diverted incoming flights in response to the shooting.

11.58pm

University Medical says at least two people are dead and 24 others are injured, 12 of them critically.

Las Vegas Metropolitan Police Department confirms "one suspect is down". Reports on social media, citing police scanners, suggest gunman was located on 32nd floor of the Mandalay Bay Hotel and Casino. Police warn people to avoid the area amid fears of other gunmen.

Las Vegas shooting – in pictures Show all 15 1 /15 Las Vegas shooting – in pictures Las Vegas shooting – in pictures People scramble for shelter at the Route 91 Harvest country music festival after gun fire was heard Getty Las Vegas shooting – in pictures People carry a person at the Route 91 Harvest country music festival after shots were fired David Becker/Getty Las Vegas shooting – in pictures People run from the Route 91 Harvest country music festival after gun fire was heard David Becker/Getty Las Vegas shooting – in pictures A handout photo released via Twitter by Eiki Hrafnsson (@EirikurH) showing concertgoers running away from the scene (C) after shots range out at the Route 91 Harvest festival on Las Vegas Boulevard EPA/Eiki Hrafnsson Las Vegas shooting – in pictures People lie on the ground at the Route 91 Harvest country music festival after hearing gun fire Getty Las Vegas shooting – in pictures A man in a wheelchair is taken away from the Route 91 Harvest country music festival after hearing gun fire David Becker/Getty Las Vegas shooting – in pictures People stand on the street outside the Mandalay Bay hotel near the scene of the Route 91 Harvest festival on Las Vegas Boulevard EPA/Paul Buck Las Vegas shooting – in pictures FBI agents confer in front of the Tropicana hotel-casino after a mass shooting during a music festival on the Las Vegas Strip Reuters/Las Vegas Sun/Steve Marcus Las Vegas shooting – in pictures Las Vegas police run by a banner on the fence at the Route 91 Harvest country music festival grounds after shots were fired David Becker/Getty Las Vegas shooting – in pictures An injured person is tended to in the intersection of Tropicana Ave. and Las Vegas Boulevard after a mass shooting at a country music festival Ethan Miller/Getty Las Vegas shooting – in pictures Metro Police officers pass by the front of the Tropicana hotel-casino after a mass shooting at a music festival on the Las Vegas Strip Reuters/Las Vegas Sun/Steve Marcus Las Vegas shooting – in pictures A woman sits on a curb at the scene of a shooting outside of a music festival along the Las Vegas Strip AP/John Locher Las Vegas shooting – in pictures A cowboy hat lays in the street after shots were fired near a country music festival in Las Vegas Getty Las Vegas shooting – in pictures Las Vegas Metro Police and medical workers stage in the intersection of Tropicana Avenue and Las Vegas Boulevard South after a mass shooting at a music festival on the Las Vegas Strip Reuters/Las Vegas Sun/Steve Marcus Las Vegas shooting – in pictures Sheriff Joe Lombardo (2-R) speaking during a press briefing in the aftermath of the active shooter incident on Las Vegas Boulevard EPA

12.30am

Police say they "do not believe there are any more shooters".

1.34am

Death toll rises to 20.

Las Vegas Police Sheriff Joseph Lombardo tells press conference shooter was local man. He says search is underway for two vehicles and 62-year-old female "person of interest" who lives with gunman and is "sought for questioning".

2.30am

Jason Aldean, who was performing on stage when shooting began, confirms he and crew are safe. He describes the attack as "beyond horrific" in an Instagram post.

3.30am

Police say death toll has risen to 50, making it the deadliest mass shooting in US history. Another 200 people have been injured.

Sheriff Lombardo says female person of interest has been located, as well as two vehicles.

4.11am

US President Donald Trump tweets his "warmest condolences and sympathies to the victims and families" of the shooting.

5.30am

Police identify suspect as Stephen Craig Paddock, a 64-year-old white man from Mesquite, Nevada. They confirm SWAT officers found him dead in his room on the 32nd floor of the Mandalay Bay Hotel.

An off-duty Las Vegas police officer who had attended the festival is confirmed to be among the dead. Another was critically wounded, say police.

The Clark County Fire Department estimates 406 people were taken to hospital with injuries following the shooting.

6am

Police say Paddock killed himself before officers forced their way into his hotel room.

7.15am

Isis claims responsibility for the massacre. A statement issued through its propaganda agency describes Paddock as a “soldier of the Islamic State” and claims he converted to Islam "several months ago".

7.50am

Donald Trump delivers televised statement describing shooting as "an act of pure evil" and praising first responders. He says he will visit Las Vegas on Wednesday.

8.40am

Death toll rises to 58 with number of injured up to 515.