Injuries were the biggest storyline in Week 2 of the 2020 NFL season, as players across the league dropped like flies during Sunday’s slate of action. As a result, the latest Super Bowl odds for which team will win the NFL’s most coveted trophy have changed significantly.

The biggest name to suffer a major injury was star New York Giants running back Saquon Barkley, who tore his ACL against the Chicago Bears, and will be out for the rest of the season.

Carolina Panthers running back Christian McCaffrey is expected to miss more than a month with an ankle injury, while the San Francisco 49ers lost standout pass rusher Joey Bosa for the remainder of the campaign, plus quarterback Jimmy Garoppolo and running back Raheem Mostert for some time. The Denver Broncos, who were already crippled by injuries, lost Courtland Sutton for the year and Drew Lock for two to six weeks.

The lack of preseason games due to the COVID-19 pandemic is clearly having a negative impact on players’ bodies. It’s a concerning trend, and one that will hopefully not continue to this magnitude going forward.

At BetOnline, the Baltimore Ravens and Kansas City Chiefs are the +500 co-favorites to win the championship, followed by the Seattle Seahawks (+900), New Orleans Saints (+1200) and San Francisco 49ers (+1400) at the top of the list.

For more information on everything you need to know about wagering on the big game, head over to our Where to Bet on the Super Bowl page. Our Best NFL Sites article will help you find the sportsbook that’s right for you to wager on the gridiron.

Who is Favored to Win the Super Bowl?

Super Bowl 55 Odds Team Current Odds Season-Opening Odds Baltimore Ravens +500 +600 Kansas City Chiefs +500 +650 Seattle Seahawks +900 +1000 New Orleans Saints +1200 +1000 San Francisco 49ers +1400 +1600 Dallas Cowboys +1600 +1200 Tampa Bay Buccaneers +1600 +2500 Buffalo Bills +1800 +1400 Green Bay Packers +1800 +2500 Pittsburgh Steelers +2000 +2200 Arizona Cardinals +2500 +2500 Los Angeles Rams +2500 +3300 New England Patriots +2500 +5000 Indianapolis Colts +2800 +6000 Tennessee Titans +2800 +2000 Las Vegas Raiders +4000 +8000 Chicago Bears +5000 +2200 Cleveland Browns +5000 +5000 Los Angeles Chargers +6000 +5000 Minnesota Vikings +6600 +8000 Philadelphia Eagles +6600 +5000 Atlanta Falcons +8000 +4000 Detroit Lions +10000 +7000 Houston Texans +10000 +5000 Denver Broncos +12500 +6600 Jacksonville Jaguars +20000 +25000 Washington Football Team +20000 +10000 Miami Dolphins +25000 +15000 Carolina Panthers +30000 +15000 Cincinnati Bengals +30000 +30000 New York Giants +30000 +15000 New York Jets +30000 +12500

Odds as of September 24 at BetOnline

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Winners From Week 2

Los Angeles Rams (+3300 to +2500)

Did oddsmakers underestimate the Rams this season? It sure looks that way through two weeks. Jared Goff and company marched into the City of Brotherly Love and put a 37-19 beatdown on the beleaguered Philadelphia Eagles to improve to 2-0.

The Rams saw the biggest positive odds shift of the week, improving from +3300 to +2500 in light of the victory. It wasn’t all good news for L.A., though, as rookie running back Cam Akers had to leave the game and shortly after was diagnosed with separated cartilage in his ribs.

Los Angeles faces a stiff test this week with a road date against the 2-0 Buffalo Bills. If the Rams can pull off a win, they’ll continue to soar up the Super Bowl oddsboard. The Rams opened as 2-point underdogs vs the Bills with a total of 47.5.

Seattle Seahawks (+1400 to +900)

Another NFC West team has been crowned the co-winner of the week according to sportsbooks, as the Seahawks leapfrogged the New Orleans Saints and San Francisco 49ers to claim the No. 3 spot on the oddsboard thanks to a big 35-30 triumph over the New England Patriots on Sunday Night Football.

Russell Wilson, who’s making a case as an extremely early NFL MVP front-runner, torched the Pats defense for five touchdowns through the air. Wilson did a good job of spreading the ball around, with D.K. Metcalf, Tyler Lockett, David Moore, Chris Carson and Freddie Swain all scoring TDs.

Wilson has never received an MVP vote in his illustrious career, a factoid he seems to be taking personally. There doesn’t seem to be any stopping the 2-0 Seahawks right now, and a home clash with the Dallas Cowboys looks like a good opportunity for Seattle to rattle off three straight wins to start the season.

Losers From Week 2

Minnesota Vikings (+3300 to +6600)

What is going on in Minnesota? The 2020 Vikings hardly resemble the club that won 10 games last season and beat the Saints in the wild-card round. Minnesota simply didn’t show up to play in Week 2, suffering a 28-11 setback at the hands of the Indianapolis Colts at Lucas Oil Stadium.

Starting quarterback Kirk Cousins put forth a pathetic performance for the Vikings, completing just 11 of 26 passes for 113 yards along with zero touchdowns and three interceptions. The Vikings defense, a unit that was perennially feared in recent seasons, let Philip Rivers and Jonathan Taylor carve them up all day long.

Minny’s drop on the board from +3300 to +6600 is the biggest odds move we’ve seen so far in the 2020 campaign. A Week 3 matchup vs the undefeated Tennessee Titans awaits, and while it’s too early to call any of these games must-wins, it would be disastrous if the Vikings start the year 0-3 given the plethora of talent on this roster.

Atlanta Falcons (+5000 to +8000)

It’s hard to deny that Falcons fans still haven’t lived down the epic 28-3 collapse to the Patriots in Super Bowl 51. Atlanta’s performance against the Dallas Cowboys in Week 2 didn’t do their fans any favors, as the Falcons blew a 20-point lead on the way to losing a 40-39 heartbreaker.

Atlanta, which went up 20-0 in the first quarter, looked to have the game in hand at halftime in the form of a 29-10 lead. Dallas responded by scoring two touchdowns in the third frame en route to a last-second game-winning field goal by kicker Greg Zuerlein after the Cowboys recovered an onside kick.

BetOnline is clearly expecting the Falcons to once again disappoint this season, and their tumble to +8000 puts them behind the Vikings, Eagles and Chargers on the list. Talent has never been the issue in Atlanta – a major reason why the seat under coach Dan Quinn is hotter than ever.

When it comes to betting on the NFL, odds are available before teams take their first regular-season snaps. You can even bet on a potential Super Bowl winner in August. Certain squads will always be contenders, especially if they won the previous year. When bookmakers set the lines, they look at offseason roster moves, coaching changes and past on-field performance. To bet on the odds for the Super Bowl, you’d make a futures bet.

What is a Futures Bet for NFL?

This is a bet in which you would look at the odds for the Super Bowl, weeks or sometimes months in advance of the big game, and decide which team you think will win. Let’s say you want to make a futures bet today. At your sportsbook of choice, the odds might look something like this:

New England Patriots +240

New Orleans Saints +550

Green Bay Packers +900

Kansas City Chiefs +950

San Francisco 49ers +1000

If this were a moneyline bet, you’d be able to see which team is the clear favorite because it would have a minus sign beside its odds (-). For futures, the team with the lowest odds is favored to win the Super Bowl and the rest are underdogs.

Let’s say you feel strongly about the Saints and believe they’re going to win it all. If you were to bet $100 on them and they did triumph, you’d get a payout of $650 – your original $100 is returned along with your winnings of $550. Our Odds Calculator will show you how much you’d win based on the odds and amount bet.

The odds change throughout the season as key players get injured, trades happen and coaches get fired. Line movements for NFL futures happen weekly, so if you see odds you like, it’s best to bet on them ASAP. The Packers may be +900 to win the Super Bowl in October but after a surge in November their odds could jump to +400 and you’ll make less money than you would if you’d bet them at +900.