Brett Favre started his 297th consecutive game Sunday against Buffalo at the Metrodome but he didn't last long in the Vikings' 38-14 victory.

The veteran quarterback injured his shoulder on a third-and-5 play on the Vikings' opening series in the first quarter when he scrambled right and was hit from behind by Bills linebacker Arthur Moats. Favre was hit as he throwing and his passed popped up in the air and was intercepted by cornerback Drayton Florence.

Favre was replaced by Tarvaris Jackson and his return was listed as questionable. Favre went to the locker room with about 6:45 left in the first quarter after being examined on the bench for an extended perio by athletic trainer Eric Sugarman and team doctor Joel Boyd. He did not return but returned to the sideline in the first half and talked about the situation with coach Leslie Frazier and Sugarman. Favre spent the rest of the game watching from the sideline with his helmet on.

Jackson completed 15 of 22 passes for 187 yards with two touchdowns and three interceptions. The Vikings improved to 5-7 with the victory over the Bills (2-10).

The Bills got the ball at the Minnesota 45-yard line after Favre's interception but went three-and-out.

When the Vikings offense returned to the field, Jackson came on in place of Favre and received a nice ovation from the crowd. On third-and-11 from his own 10-yard line, Jackson found Sidney Rice on a 46-yard completion.

It was the second time this season Favre has had to leave a game because of injury. He also exited the Vikings' loss at New England on Oct. 31 when he suffered a gash in his chin that required stitches.