If you're on Windows the easiest way is by putting the script in the Python directory where python.exe is located and opening a command prompt, using cd "C:\path\to\python" to get to the Python directory, then use the command described in the first post but add python.exe followed by a space in front of it so it becomes python.exe patch.py "c:\path\to\game.cia"

Instead of typing the cia path manually you can drag and drop the file onto the command prompt window to autofill the path. This probably also works for the cd command by drag&dropping the Python directory.

Make sure you use Python 3.x and not 2.x since this particular script needs it.

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