Monday, March 06, 2006 by: Dani Veracity ( Saved via Wayback 2020 )

The true U.S. history of human medical experimentation

Human experimentation — that is, subjecting live human beings to science experiments that are sometimes cruel, sometimes painful, sometimes deadly and always a risk — is a major part of U.S. history that you won’t find in most history or science books. The United States is undoubtedly responsible for some of the most amazing scientific breakthroughs. These advancements, especially in the field of medicine, have changed the lives of billions of people around the world — sometimes for the better, as in the case of finding a cure for malaria and other epidemic diseases, and sometimes for the worse (consider modern “psychiatry” and the drugging of schoolchildren).

However, these breakthroughs come with a hefty price tag: The human beings used in the experiments that made these advancements possible. Over the last two centuries, some of these test subjects have been compensated for the damage done to their emotional and physical health, but most have not. Many have lost their lives because of the experiments they often unwillingly and sometimes even unwittingly participated in, and they of course can never be compensated for losing their most precious possession of all: Their health.

As you read through these science experiments, you’ll learn the stories of newborns injected with radioactive substances, mentally ill people placed in giant refrigerators, military personnel exposed to chemical weapons by the very government they served and mentally challenged children being purposely infected with hepatitis. These stories are facts, not fiction: Each account, no matter how horrifying, is backed up with a link or citation to a reputable source.

These stories must be heard because human experimentation is still going on today. The reasons behind the experiments may be different, but the usual human guinea pigs are still the same — members of minority groups, the poor and the disadvantaged. These are the lives that were put on the line in the name of “scientific” medicine.

(1833)

Dr. William Beaumont, an army surgeon physician, pioneers gastric medicine with his study of a patient with a permanently open gunshot wound to the abdomen and writes a human medical experimentation code that asserts the importance of experimental treatments, but also lists requirements stipulating that human subjects must give voluntary, informed consent and be able to end the experiment when they want. Beaumont’s Code lists verbal, rather than just written, consent as permissible (Berdon).

(1845)

(1845 – 1849) J. Marion Sims, later hailed as the “father of gynecology,” performs medical experiments on enslaved African women without anesthesia. These women would usually die of infection soon after surgery. Based on his belief that the movement of newborns’ skull bones during protracted births causes trismus, he also uses a shoemaker’s awl, a pointed tool shoemakers use to make holes in leather, to practice moving the skull bones of babies born to enslaved mothers (Brinker).

(1895)

New York pediatrician Henry Heiman infects a 4-year-old boy whom he calls “an idiot with chronic epilepsy” with gonorrhea as part of a medical experiment (“Human Experimentation: Before the Nazi Era and After”).

(1896)

Dr. Arthur Wentworth turns 29 children at Boston’s Children’s Hospital into human guinea pigs when he performs spinal taps on them, just to test whether the procedure is harmful (Sharav).

(1900)

U.S Army doctors working in the Philippines infect five Filipino prisoners with plague and withhold proper nutrition to create Beriberi in 29 prisoners; four test subjects die (Merritte, et al.; Cockburn and St. Clair, eds.).

Under commission from the U.S. surgeon general, Dr. Walter Reed goes to Cuba and uses 22 Spanish immigrant workers to prove that yellow fever is contracted through mosquito bites. Doing so, he introduces the practice of using healthy test subjects, and also the concept of a written contract to confirm informed consent of these subjects. While doing this study, Dr. Reed clearly tells the subjects that, though he will do everything he can to help them, they may die as a result of the experiment. He pays them $100 in gold for their participation, plus $100 extra if they contract yellow fever (Berdon, Sharav).

(1906)

Harvard professor Dr. Richard Strong infects prisoners in the Philippines with cholera to study the disease; 13 of them die. He compensates survivors with cigars and cigarettes. During the Nuremberg Trials, Nazi doctors cite this study to justify their own medical experiments (Greger, Sharav).

(1911)

Dr. Hideyo Noguchi of the Rockefeller Institute for Medical Research publishes data on injecting an inactive syphilis preparation into the skin of 146 hospital patients and normal children in an attempt to develop a skin test for syphilis. Later, in 1913, several of these children’s parents sue Dr. Noguchi for allegedly infecting their children with syphilis (“Reviews and Notes: History of Medicine: Subjected to Science: Human Experimentation in America before the Second World War”).

(1913)

Medical experimenters “test” 15 children at the children’s home St. Vincent’s House in Philadelphia with tuberculin, resulting in permanent blindness in some of the children. Though the Pennsylvania House of Representatives records the incident, the researchers are not punished for the experiments (“Human Experimentation: Before the Nazi Era and After”).

(1915)

Dr. Joseph Goldberger, under order of the U.S. Public Health Office, produces Pellagra, a debilitating disease that affects the central nervous system, in 12 Mississippi inmates to try to find a cure for the disease. One test subject later says that he had been through “a thousand hells.” In 1935, after millions die from the disease, the director of the U.S Public Health Office would finally admit that officials had known that it was caused by a niacin deficiency for some time, but did nothing about it because it mostly affected poor African-Americans. During the Nuremberg Trials, Nazi doctors used this study to try to justify their medical experiments on concentration camp inmates (Greger; Cockburn and St. Clair, eds.).

(1918)

In response to the Germans’ use of chemical weapons during World War I, President Wilson creates the Chemical Warfare Service (CWS) as a branch of the U.S. Army. Twenty-four years later, in 1942, the CWS would begin performing mustard gas and lewisite experiments on over 4,000 members of the armed forces (Global Security, Goliszek).

(1919)

(1919 – 1922) Researchers perform testicular transplant experiments on inmates at San Quentin State Prison in California, inserting the testicles of recently executed inmates and goats into the abdomens and scrotums of living prisoners (Greger).

(1931)

Cornelius Rhoads, a pathologist from the Rockefeller Institute for Medical Research, purposely infects human test subjects in Puerto Rico with cancer cells; 13 of them die. Though a Puerto Rican doctor later discovers that Rhoads purposely covered up some of details of his experiment and Rhoads himself gives a written testimony stating he believes that all Puerto Ricans should be killed, he later goes on to establish the U.S. Army Biological Warfare facilities in Maryland, Utah and Panama, and is named to the U.S. Atomic Energy Commission, where he begins a series of radiation exposure experiments on American soldiers and civilian hospital patients (Sharav; Cockburn and St. Clair, eds.).

(1931 – 1933) Mental patients at Elgin State Hospital in Illinois are injected with radium-266 as an experimental therapy for mental illness (Goliszek).

(1932)

(1932-1972) The U.S. Public Health Service in Tuskegee, Ala. diagnoses 400 poor, black sharecroppers with syphilis but never tells them of their illness nor treats them; instead researchers use the men as human guinea pigs to follow the symptoms and progression of the disease. They all eventually die from syphilis and their families are never told that they could have been treated (Goliszek, University of Virginia Health System Health Sciences Library).

(1937)

Scientists at Cornell University Medical School publish an angina drug study that uses both placebo and blind assessment techniques on human test subjects. They discover that the subjects given the placebo experienced more of an improvement in symptoms than those who were given the actual drug. This is first account of the placebo effect published in the United States (“Placebo Effect”).

(1939)

In order to test his theory on the roots of stuttering, prominent speech pathologist Dr. Wendell Johnson performs his famous “Monster Experiment” on 22 children at the Iowa Soldiers’ Orphans’ Home in Davenport. Dr. Johnson and his graduate students put the children under intense psychological pressure, causing them to switch from speaking normally to stuttering heavily. At the time, some of the students reportedly warn Dr. Johnson that, “in the aftermath of World War II, observers might draw comparisons to Nazi experiments on human subjects, which could destroy his career” (Alliance for Human Research Protection).

(1941)

Dr. William C. Black infects a 12-month-old baby with herpes as part of a medical experiment. At the time, the editor of the Journal of Experimental Medicine, Francis Payton Rous, calls it “an abuse of power, an infringement of the rights of an individual, and not excusable because the illness which followed had implications for science” (Sharav).

An article in a 1941 issue of Archives of Pediatrics describes medical studies of the severe gum disease Vincent’s angina in which doctors transmit the disease from sick children to healthy children with oral swabs (Goliszek).

Drs. Francis and Salk and other researchers at the University of Michigan spray large amounts of wild influenza virus directly into the nasal passages of “volunteers” from mental institutions in Michigan. The test subjects develop influenza within a very short period of time (Meiklejohn).

Researchers give 800 poverty-stricken pregnant women at a Vanderbilt University prenatal clinic “cocktails” including radioactive iron in order to determine the iron requirements of pregnant women (Pacchioli).

(1942)

The United States creates Fort Detrick, a 92-acre facility, employing nearly 500 scientists working to create biological weapons and develop defensive measures against them. Fort Detrick’s main objectives include investigating whether diseases are transmitted by inhalation, digestion or through skin absorption; of course, these biological warfare experiments heavily relied on the use of human subjects (Goliszek).

U.S. Army and Navy doctors infect 400 prison inmates in Chicago with malaria to study the disease and hopefully develop a treatment for it. The prisoners are told that they are helping the war effort, but not that they are going to be infected with malaria. During Nuremberg Trials, Nazi doctors later cite this American study to defend their own medical experiments in concentration camps like Auschwitz (Cockburn and St. Clair, eds.).

The Chemical Warfare Service begins mustard gas and lewisite experiments on 4,000 members of the U.S. military. Some test subjects don’t realize they are volunteering for chemical exposure experiments, like 17-year-old Nathan Schnurman, who in 1944 thinks he is only volunteering to test “U.S. Navy summer clothes” (Goliszek).

In an experiment sponsored by the U.S. Navy, Harvard biochemist Edward Cohn injects 64 inmates of Massachusetts state prisons with cow’s blood (Sharav).

Merck Pharmaceuticals President George Merck is named director of the War Research Service (WRS), an agency designed to oversee the establishment of a biological warfare program (Goliszek).

(1943)

In order to “study the effect of frigid temperature on mental disorders,” researchers at University of Cincinnati Hospital keep 16 mentally disabled patients in refrigerated cabinets for 120 hours at 30 degrees Fahrenheit (Sharav).

(1944)

As part of the Manhattan Project that would eventually create the atomic bomb, researchers inject 4.7 micrograms of plutonium into soldiers at the Oak Ridge facility, 20 miles west of Knoxville, Tenn. (“Manhattan Project: Oak Ridge”).

Captain A. W. Frisch, an experienced microbiologist, begins experiments on four volunteers from the state prison at Dearborn, Mich., inoculating prisoners with hepatitis-infected specimens obtained in North Africa. One prisoner dies; two others develop hepatitis but live; the fourth develops symptoms but does not actually develop the disease (Meiklejohn).

Laboratory workers at the University of Minnesota and University of Chicago inject human test subjects with phosphorus-32 to learn the metabolism of hemoglobin (Goliszek).

(1944 – 1946) In order to quickly develop a cure for malaria — a disease hindering Allied success in World War II — University of Chicago Medical School professor Dr. Alf Alving infects psychotic patients at Illinois State Hospital with the disease through blood transfusions and then experiments malaria cures on them (Sharav).

A captain in the medical corps addresses an April 1944 memo to Col. Stanford Warren, head of the Manhattan Project’s Medical Section, expressing his concerns about atom bomb component fluoride’s central nervous system (CNS) effects and asking for animal research to be done to determine the extent of these effects: “Clinical evidence suggests that uranium hexafluoride may have a rather marked central nervous system effect … It seems most likely that the F component rather than the T is the causative factor ... Since work with these compounds is essential, it will be necessary to know in advance what mental effects may occur after exposure." The following year, the Manhattan Project would begin human-based studies on fluoride's effects (Griffiths and Bryson).

The Manhattan Project medical team, led by the now infamous University of Rochester radiologist Col. Safford Warren, injects plutonium into patients at the University's teaching hospital, Strong Memorial (Burton Report).

(1945)

Continuing the Manhattan Project, researchers inject plutonium into three patients at the University of Chicago's Billings Hospital (Sharav).

The U.S. State Department, Army intelligence and the CIA begin Operation Paperclip, offering Nazi scientists immunity and secret identities in exchange for work on top-secret government projects on aerodynamics and chemical warfare medicine in the United States ("Project Paperclip").

Researchers infect 800 prisoners in Atlanta with malaria to study the disease (Sharav).

(1945 - 1955) In Newburgh, N.Y., researchers linked to the Manhattan Project begin the most extensive American study ever done on the health effects of fluoridating public drinking water (Griffiths and Bryson).

(1946)

Gen. Douglas MacArthur strikes a secret deal with Japanese physician Dr. Shiro Ishii to turn over 10,000 pages of information gathered from human experimentation in exchange for granting Ishii immunity from prosecution for the horrific experiments he performed on Chinese, Russian and American war prisoners, including performing vivisections on live human beings (Goliszek, Sharav).

Male and female test subjects at Chicago's Argonne National Laboratories are given intravenous injections of arsenic-76 so that researchers can study how the human body absorbs, distributes and excretes arsenic (Goliszek).

Continuing the Newburg study of 1945, the Manhattan Project commissions the University of Rochester to study fluoride's effects on animals and humans in a project codenamed "Program F." With the help of the New York State Health Department, Program F researchers secretly collect and analyze blood and tissue samples from Newburg residents. The studies are sponsored by the Atomic Energy Commission and take place at the University of Rochester Medical Center's Strong Memorial Hospital (Griffiths and Bryson).

(1946 - 1947) University of Rochester researchers inject four male and two female human test subjects with uranium-234 and uranium-235 in dosages ranging from 6.4 to 70.7 micrograms per one kilogram of body weight in order to study how much uranium they could tolerate before their kidneys become damaged (Goliszek).

Six male employees of a Chicago metallurgical laboratory are given water contaminated with plutonium-239 to drink so that researchers can learn how plutonium is absorbed into the digestive tract (Goliszek).

Researchers begin using patients in VA hospitals as test subjects for human medical experiments, cleverly worded as "investigations" or "observations" in medical study reports to avoid negative connotations and bad publicity (Sharav).

The American public finally learns of the biowarfare experiments being done at Fort Detrick from a report released by the War Department (Goliszek).

(1946 - 1953) The U.S. Atomic Energy Commission sponsors studies in which researchers from Harvard Medical School, Massachusetts General Hospital and the Boston University School of Medicine feed mentally disabled students at Fernald State School Quaker Oats breakfast cereal spiked with radioactive tracers every morning so that nutritionists can study how preservatives move through the human body and if they block the absorption of vitamins and minerals. Later, MIT researchers conduct the same study at Wrentham State School (Sharav, Goliszek).

Human test subjects are given one to four injections of arsenic-76 at the University of Chicago Department of Medicine. Researchers take tissue biopsies from the subjects before and after the injections (Goliszek).

(1947)

Col. E.E. Kirkpatrick of the U.S. Atomic Energy Commission (AEC) issues a top-secret document (707075) dated Jan. 8. In it, he writes that "certain radioactive substances are being prepared for intravenous administration to human subjects as a part of the work of the contract" (Goliszek).

A secret AEC document dated April 17 reads, "It is desired that no document be released which refers to experiments with humans that might have an adverse reaction on public opinion or result in legal suits," revealing that the U.S. government was aware of the health risks its nuclear tests posed to military personnel conducting the tests or nearby civilians (Goliszek).

The CIA begins studying LSD's potential as a weapon by using military and civilian test subjects for experiments without their consent or even knowledge. Eventually, these LSD studies will evolve into the MKULTRA program in 1953 (Sharav).

(1947 - 1953) The U.S. Navy begins Project Chatter to identify and test so-called "truth serums," such as those used by the Soviet Union to interrogate spies. Mescaline and the central nervous system depressant scopolamine are among the many drugs tested on human subjects (Goliszek).

(1948)

Based on the secret studies performed on Newburgh, N.Y. residents beginning in 1945, Project F researchers publish a report in the August 1948 edition of the Journal of the American Dental Association, detailing fluoride's health dangers. The U.S. Atomic Energy Commission (AEC) quickly censors it for "national security" reasons (Griffiths and Bryson).

(1950)

(1950 - 1953) The CIA and later the Office of Scientific Intelligence begin Project Bluebird (renamed Project Artichoke in 1951) in order to find ways to "extract" information from CIA agents, control individuals "through special interrogation techniques," "enhance memory" and use "unconventional techniques, including hypnosis and drugs" for offensive measures (Goliszek).

(1950 - 1953) The U.S. Army releases chemical clouds over six American and Canadian cities. Residents in Winnipeg, Canada, where a highly toxic chemical called cadmium is dropped, subsequently experience high rates of respiratory illnesses (Cockburn and St. Clair, eds.).

In order to determine how susceptible an American city could be to biological attack, the U.S. Navy sprays a cloud of Bacillus globigii bacteria from ships over the San Francisco shoreline. According to monitoring devices situated throughout the city to test the extent of infection, the eight thousand residents of San Francisco inhale five thousand or more bacteria particles, many becoming sick with pneumonia-like symptoms (Goliszek).

Dr. Joseph Strokes of the University of Pennsylvania infects 200 female prisoners with viral hepatitis to study the disease (Sharav).

Doctors at the Cleveland City Hospital study changes in cerebral blood flow by injecting test subjects with spinal anesthesia, inserting needles in their jugular veins and brachial arteries, tilting their heads down and, after massive blood loss causes paralysis and fainting, measuring their blood pressure. They often perform this experiment multiple times on the same subject (Goliszek).

Dr. D. Ewen Cameron, later of MKULTRA infamy due to his 1957 to1964 experiments on Canadians, publishes an article in the British Journal of Physical Medicine, in which he describes experiments that entail forcing schizophrenic patients at Manitoba's Brandon Mental Hospital to lie naked under 15- to 200-watt red lamps for up to eight hours per day. His other experiments include placing mental patients in an electric cage that overheats their internal body temperatures to 103 degrees Fahrenheit, and inducing comas by giving patients large injections of insulin (Goliszek).

(1951)

The U.S. Navy's Project Bluebird is renamed Project Artichoke and begins human medical experiments that test the effectiveness of LSD, sodium pentothal and hypnosis for the interrogative purposes described in Project Bluebird's objectives (1950) (Goliszek).

The U.S. Army secretly contaminates the Norfolk Naval Supply Center in Virginia and Washington, D.C.'s National Airport with a strain of bacteria chosen because African-Americans were believed to be more susceptible to it than Caucasians. The experiment causes food poisoning, respiratory problems and blood poisoning (Cockburn and St. Clair, eds.).

(1951 - 1952) Researchers withhold insulin from diabetic patients for up to two days in order to observe the effects of diabetes; some test subjects go into diabetic comas (Goliszek).

(1951 - 1956) Under contract with the Air Force's School of Aviation Medicine (SAM), the University of Texas M.D. Anderson Cancer Center in Houston begins studying the effects of radiation on cancer patients -- many of them members of minority groups or indigents, according to sources -- in order to determine both radiation's ability to treat cancer and the possible long-term radiation effects of pilots flying nuclear-powered planes. The study lasts until 1956, involving 263 cancer patients. Beginning in 1953, the subjects are required to sign a waiver form, but it still does not meet the informed consent guidelines established by the Wilson memo released that year. The TBI studies themselves would continue at four different institutions -- Baylor University College of Medicine, Memorial Sloan-Kettering Institute for Cancer Research, the U.S. Naval Hospital in Bethesda and the University of Cincinnati College of Medicine -- until 1971 (U.S. Department of Energy, Goliszek).

American, Canadian and British military and intelligence officials gather a small group of eminent psychologists to a secret meeting at the Ritz-Carlton Hotel in Montreal about Communist "thought-control techniques." They proposed a top-secret research program on behavior modification -- involving testing drugs, hypnosis, electroshock and lobotomies on humans (Barker).

(1952)

Military scientists use the Dugway Proving Ground -- which is located 87 miles southwest of Salt Lake City, Utah -- in a series of experiments to determine how Brucella suis and Brucella melitensis spread in human populations. Today, over a half-century later, some experts claim that we are all infected with these agents as a result of these experiments (Goliszek).

In a U.S. Department of Denfense-sponsored experiment, Henry Blauer dies after he is injected with mescaline at Columbia University's New York State Psychiatric Institute (Sharav).

At the famous Sloan-Kettering Institute, Chester M. Southam injects live cancer cells into prisoners at the Ohio State Prison to study the progression of the disease. Half of the prisoners in this National Institutes of Health-sponsored (NIH) study are black, awakening racial suspicions stemming from Tuskegee, which was also an NIH-sponsored study (Merritte, et al.).

(1953)

(1953 - 1970) The CIA begins project MKNAOMI to "stockpile incapacitating and lethal materials, to develop gadgetry for the disseminations of these materials, and to test the effects of certain drugs on animals and humans." As part of MKNAOMI, the CIA and the Special Operations Division of the Army Biological Laboratory at Fort Detrick try to develop two suicide pill alternatives to the standard cyanide suicide pill given to CIA agents and U-2 pilots. CIA agents and U-2 pilots are meant to take these pills when they find themselves in situations in which they (and all the information they hold in their brains) are in enemy hands. They also develop a "microbioinoculator" -- a device that agents can use to fire small darts coated with biological agents that can remain potent for weeks or even months. These darts can be fired through clothing and, most significantly, are undetectable during autopsy. Eventually, by the late 1960s, MKNAOMI enables the CIA to have a stockpile of biological toxins -- infectious viruses, paralytic shellfish toxin, lethal botulism toxin, snake venom and the severe skin disease-producing agent Mircosporum gypseum. Of course, the development of all of this "gadgetry" requires human experimentation (Goliszek).

(1953 - 1974) CIA Director Allen Dulles authorizes the MKULTRA program to produce and test drugs and biological agents that the CIA could use for mind control and behavior modification. MKULTRA later becomes well known for its pioneering studies on LSD, which are often performed on prisoners or patrons of brothels set up and run by the CIA. The brothel experiments, known as "Operation Midnight Climax," feature two-way mirrors set up in the brothels so that CIA agents can observe LSD's effects on sexual behavior. Ironically, governmental figures sometimes slip LSD into each other's drinks as part of the program, resulting in the LSD psychosis-induced suicide of Dr. Frank Olson indirectly at the hands of MKULTRA's infamous key player Dr. Sidney Gottlieb. Of all the hundreds of human test subjects used during MKULTRA, only 14 are ever notified of the involvement and only one is ever compensated ($15,000). Most of the MKULTRA files are eventually destroyed in 1973 (Elliston; Merritte, et al.; Barker).

The U.S. Atomic Energy Commission (AEC) sponsors iodine studies at the University of Iowa. In the first study, researchers give pregnant women 100 to 200 microcuries of iodine-131 and then study the women's aborted embryos in order to learn at what stage and to what extent radioactive iodine crosses the placental barrier. In the second study, researchers give 12 male and 13 female newborns under 36 hours old and weighing between 5.5 and 8.5 pounds iodine-131 either orally or via intramuscular injection, later measuring the concentration of iodine in the newborns' thyroid glands (Goliszek).

Secretary of Defense Charles Wilson issues the Wilson memo, a top-secret document establishing the Nuremberg Code as Department of Defense policy on human experimentation. The Wilson memo requires voluntary, written consent from a human medical research subject after he or she has been informed of "the nature, duration, and purpose of the experiment; the method and means by which it is to be conducted; all inconveniences and hazards reasonably to be expected; and effects upon his health or person which may possibly come from his participation in the experiment." It also insists that doctors only use experimental treatments when other methods have failed (Berdon).

As part of an AEC study, researchers feed 28 healthy infants at the University of Nebraska College of Medicine iodine-131 through a gastric tube and then test concentration of iodine in the infants' thyroid glands 24 hours later (Goliszek).

(1953 - 1957) Eleven patients at Massachusetts General Hospital in Boston are injected with uranium as part of the Manhattan Project (Sharav).

In an AEC-sponsored study at the University of Tennessee, researchers inject healthy two- to three-day-old newborns with approximately 60 rads of iodine-131 (Goliszek).

Newborn Daniel Burton becomes blind when physicians at Brooklyn Doctors Hospital perform an experimental high oxygen treatment for Retrolental Fibroplasia, a retinal disorder affecting premature infants, on him and other premature babies. The physicians perform the experimental treatment despite earlier studies showing that high oxygen levels cause blindness. Testimony in Burton v. Brooklyn Doctors Hospital (452 N.Y.S.2d875) later reveals that researchers continued to give Burton and other infants excess oxygen even after their eyes had swelled to dangerous levels (Goliszek, Sharav).

The CIA begins Project MKDELTA to study the use of biochemicals "for harassment, discrediting and disabling purposes" (Goliszek).

A 1953 article in Clinical Science describes a medical experiment in which researchers purposely blister the abdomens of 41 children, ranging in age from eight to 14, with cantharide in order to study how severely the substance irritates the skin (Goliszek).

The AEC performs a series of field tests known as "Green Run," dropping radiodine 131 and xenon 133 over the Hanford, Wash. site -- 500,000 acres encompassing three small towns (Hanford, White Bluffs and Richland) along the Columbia River (Sharav).

In an AEC-sponsored study to learn whether radioactive iodine affects premature babies differently from full-term babies, researchers at Harper Hospital in Detroit give oral doses of iodine-131 to 65 premature and full-term infants weighing between 2.1 and 5.5 pounds (Goliszek).

(1954)

The CIA begins Project QKHILLTOP to study Chinese Communist Party brainwashing techniques and use them to further the CIA's own interrogative methods. Most experts speculate that the Cornell University Medical School Human Ecology Studies Program conducted Project QKHILLTOP's early experiments (Goliszek).

(1954 - 1975) U.S. Air Force medical officers assigned to Fort Detrick's Chemical Corps Biological Laboratory begin Operation Whitecoat -- experiments involving exposing human test subjects to hepatitis A, plague, yellow fever, Venezuelan equine encephalitis, Rift Valley fever, rickettsia and intestinal microbes. These test subjects include 2,300 Seventh Day Adventist military personnel, who choose to become human guinea pigs rather than potentially kill others in combat. Only two of the 2,300 claim long-term medical complications from participating in the study ("Operation Whitecoat".)

In a general memo to university researchers under contract with the military, the Surgeon General of the U.S. Army asserts the human experimentation guidelines -- including informed, written consent -- established in the classified Wilson memo (Goliszek).

(1955)

In U.S. Army-sponsored experiments performed at Tulane University, mental patients are given LSD and other drugs and then have electrodes implanted in their brain to measure the levels (Barker, "The Cold War Experiments").

(1955 - 1957) In order to learn how cold weather affects human physiology, researchers give a total of 200 doses of iodine-131, a radioactive tracer that concentrates almost immediately in the thyroid gland, to 85 healthy Eskimos and 17 Athapascan Indians living in Alaska. They study the tracer within the body by blood, thyroid tissue, urine and saliva samples from the test subjects. Due to the language barrier, no one tells the test subjects what is being done to them, so there is no informed consent (Goliszek).

(1955 - 1965) As a result of their work with the CIA's mind control experiments in Project QKHILLTOP, Cornell neurologists Harold Wolff and Lawrence Hinkle begin the Society for the Investigation of Human Ecology (later renamed the Human Ecology Fund) to study "man's relation to his social environment as perceived by him" (Goliszek).

(1956)

(1956 - 1957) U.S. Army covert biological weapons researchers release mosquitoes infected with yellow fever and dengue fever over Savannah, Ga., and Avon Park, Fla., to test the insects' ability to carry disease. After each test, Army agents pose as public health officials to test victims for effects and take pictures of the unwitting test subjects. These experiments result in a high incidence of fevers, respiratory distress, stillbirths, encephalitis and typhoid among the two cities' residents, as well as several deaths (Cockburn and St. Clair, eds.).

(1957)

The U.S. military conducts Operation Plumbbob at the Nevada Test Site, 65 miles northwest of Las Vegas. Operation Pumbbob consists of 29 nuclear detonations, eventually creating radiation expected to result in a total 32,000 cases of thyroid cancer among civilians in the area. Around 18,000 members of the U.S. military participate in Operation Pumbbob's Desert Rock VII and VIII, which are designed to see how the average foot soldier physiologically and mentally responds to a nuclear battlefield ("Operation Plumbbob", Goliszek).

(1957 - 1964) As part of MKULTRA, the CIA pays McGill University Department of Psychiatry founder Dr. D. Ewen Cameron $69,000 to perform LSD studies and potentially lethal experiments on Canadians being treated for minor disorders like post-partum depression and anxiety at the Allan Memorial Institute, which houses the Psychiatry Department of the Royal Victoria Hospital in Montreal. The CIA encourages Dr. Cameron to fully explore his "psychic driving" concept of correcting madness through completely erasing one's memory and rewriting the psyche. These "driving" experiments involve putting human test subjects into drug-, electroshock- and sensory deprivation-induced vegetative states for up to three months, and then playing tape loops of noise or simple repetitive statements for weeks or months in order to "rewrite" the "erased" psyche. Dr. Cameron also gives human test subjects paralytic drugs and electroconvulsive therapy 30 to 40 times, as part of his experiments. Most of Dr. Cameron's test subjects suffer permanent damage as a result of his work (Goliszek, "Donald Ewan Cameron").

In order to study how blood flows through children's brains, researchers at Children's Hospital in Philadelphia perform the following experiment on healthy children, ranging in age from three to 11: They insert needles into each child's femoral artery (thigh) and jugular vein (neck), bringing the blood down from the brain. Then, they force each child to inhale a special gas through a facemask. In their subsequent Journal of Clinical Investigation article on this study, the researchers note that, in order to perform the experiment, they had to restrain some of the child test subjects by bandaging them to boards (Goliszek).

(1958)

Approximately 300 members of the U.S. Navy are exposed to radiation when the Navy destroyer Mansfield detonates 30 nuclear bombs off the coasts of Pacific Islands during Operation Hardtack (Goliszek).

The U.S. Atomic Energy Commission (AEC) drops radioactive materials over Point Hope, Alaska, home to the Inupiats, in a field test known under the codename "Project Chariot" (Sharav).

(1961)

In response to the Nuremberg Trials, Yale psychologist Stanley Milgram begins his famous Obedience to Authority Study in order to answer his question "Could it be that (Adolf) Eichmann and his million accomplices in the Holocaust were just following orders? Could we call them all accomplices?" Male test subjects, ranging in age from 20 to 40 and coming from all education backgrounds, are told to give "learners" electric shocks for every wrong answer the learners give in response to word pair questions. In reality, the learners are actors and are not receiving electric shocks, but what matters is that the test subjects do not know that. Astoundingly, they keep on following orders and continue to administer increasingly high levels of "shocks," even after the actor learners show obvious physical pain ("Milgram Experiment").

(1962)

Researchers at the Laurel Children's Center in Maryland test experimental acne antibiotics on children and continue their tests even after half of the young test subjects develop severe liver damage because of the experimental medication (Goliszek). The U.S. Army's Deseret Test Center begins Project 112. This includes SHAD (Shipboard Hazard and Defense), which exposes U.S. Navy and Army personnel to live toxins and chemical poisons in order to determine naval ships' vulnerability to chemical and biological weapons. Military personnel are not test subjects; conducting the tests exposes them. Many of these participants complain of negative health effects at the time and, decades later, suffer from severe medical problems as a result of their exposure (Goliszek, Veterans Health Administration).

The FDA begins requiring that a new pharmaceutical undergo three human clinical trials before it will approve it. From 1962 to 1980, pharmaceutical companies satisfy this requirement by running Phase I trials, which determine a drug's toxicity, on prison inmates, giving them small amounts of cash for compensation (Sharav).

(1963)

Chester M. Southam, who injected Ohio State Prison inmates with live cancer cells in 1952, performs the same procedure on 22 senile, African-American female patients at the Brooklyn Jewish Chronic Disease Hospital in order to watch their immunological response. Southam tells the patients that they are receiving "some cells," but leaves out the fact that they are cancer cells. He claims he doesn't obtain informed consent from the patients because he does not want to frighten them by telling them what he is doing, but he nevertheless temporarily loses his medical license because of it. Ironically, he eventually becomes president of the American Cancer Society (Greger, Merritte, et al.).

Researchers at the University of Washington directly irradiate the testes of 232 prison inmates in order to determine radiation's effects on testicular function. When these inmates later leave prison and have children, at least four have babies born with birth defects. The exact number is unknown because researchers never follow up on the men to see the long-term effects of their experiment (Goliszek).

In a National Institutes of Health-sponsored (NIH) study, a researcher transplants a chimpanzee's kidney into a human. The experiment fails (Sharav).

(1963 - 1966) New York University researcher Saul Krugman promises parents with mentally disabled children definite enrollment into the Willowbrook State School in Staten Island, N.Y., a resident mental institution for mentally retarded children, in exchange for their signatures on a consent form for procedures presented as "vaccinations." In reality, the procedures involve deliberately infecting children with viral hepatitis by feeding them an extract made from the feces of infected patients, so that Krugman can study the course of viral hepatitis as well the effectiveness of a hepatitis vaccine (Hammer Breslow).

(1963 - 1971) Leading endocrinologist Dr. Carl Heller gives 67 prison inmates at Oregon State Prison in Salem $5 per month and $25 per testicular tissue biopsy in compensation for allowing him to perform irradiation experiments on their testes. If they receive vasectomies at the end of the study, the prisoners are given an extra $100 (Sharav, Goliszek).

Researchers inject a genetic compound called radioactive thymidine into the testicles of more than 100 Oregon State Penitentiary inmates to learn whether sperm production is affected by exposure to steroid hormones (Greger).

In a study published in Pediatrics, researchers at the University of California's Department of Pediatrics use 113 newborns ranging in age from one hour to three days old in a series of experiments used to study changes in blood pressure and blood flow. In one study, doctors insert a catheter through the newborns' umbilical arteries and into their aortas and then immerse the newborns' feet in ice water while recording aortic pressure. In another experiment, doctors strap 50 newborns to a circumcision board, tilt the table so that all the blood rushes to their heads and then measure their blood pressure (Goliszek).

(1964)

(1964 - 1968) The U.S. Army pays $386,486 (the largest sum ever paid for human experimentation) to University of Pennsylvania Professors Albert Kligman and Herbert W. Copelan to run medical experiments on 320 inmates of Holmesburg Prison to determine the effectiveness of seven mind-altering drugs. The researchers' objective is to determine the minimum effective dose of each drug needed to disable 50 percent of any given population (MED-50). Though Professors Kligman and Copelan claim that they are unaware of any long-term effects the mind-altering agents might have on prisoners, documents revealed later would prove otherwise (Kaye).

(1964 - 1967) The Dow Chemical Company pays Professor Kligman $10,000 to learn how dioxin -- a highly toxic, carcinogenic component of Agent Orange -- and other herbicides affect human skin because workers at the chemical plant have been developing an acne-like condition called Chloracne and the company would like to know whether the chemicals they are handling are to blame. As part of the study, Professor Kligman applies roughly the amount of dioxin Dow employees are exposed to on the skin 60 prisoners, and is disappointed when the prisoners show no symptoms of Chloracne. In 1980 and 1981, the human guinea pigs used in this study would begin suing Professor Kligman for complications including lupus and psychological damage (Kaye).

(1965)

The Department of Defense uses human test subjects wearing rubber clothing and M9A1 masks to conduct 35 trials near Fort Greely, Ala., as part of the Elk Hunt tests, which are designed to measure the amount of VX nerve agent put on the clothing of people moving through VX-contaminated areas or touching contaminated vehicles, and the amount of VX vapor rising from these areas. After the tests, the subjects are decontaminated using wet steam and high-pressure cold water (Goliszek).

As part of a test codenamed "Big Tom," the Department of Defense sprays Oahu, Hawaii's most heavily populated island, with Bacillus globigii in order to simulate an attack on an island complex. Bacillus globigii causes infections in people with weakened immune systems, but this was not known to scientists at the time (Goliszek, Martin).

(1966)

The CIA continues a limited number of MKULTRA plans by beginning Project MKSEARCH to develop and test ways of using biological, chemical and radioactive materials in intelligence operations, and also to develop and test drugs that are able to produce predictable changes in human behavior and physiology (Goliszek).

Dr. Henry Beecher writes, "The well-being, the health, even the actual or potential life of all human beings, born or unborn, depend upon the continuing experimentation in man. Proceed it must; proceed it will. 'The proper study of mankind is man,'" in his "exposé" on human medical experimentation Research and the Individual ("Human Experimentation: Before the Nazi Era and After").

U.S. Army scientists drop light bulbs filled with Bacillus subtilis through ventilation gates and into the New York City subway system, exposing more than one million civilians to the bacteria (Goliszek).

The National Commission for the Protection of Research Subjects issues its Policies for the Protection of Human Subjects, which eventually creates what we now know as institutional review boards (IRBs) (Sharav).

(1967)

Continuing on his Dow Chemical Company-sponsored dioxin study without the company's knowledge or consent, University of Pennsylvania Professor Albert Kligman increases the dosage of dioxin he applies to 10 prisoners' skin to 7,500 micrograms, 468 times the dosage Dow official Gerald K. Rowe had authorized him to administer. As a result, the prisoners experience acne lesions that develop into inflammatory pustules and papules (Kaye).

The CIA places a chemical in the drinking water supply of the FDA headquarters in Washington, D.C. to see whether it is possible to spike drinking water with LSD and other substances (Cockburn and St. Clair, eds.).

In a study published in the Journal of Clinical Investigation, researchers inject pregnant women with radioactive cortisol to see if the radioactive material will cross the placentas and affect the fetuses (Goliszek).

The U.S. Army pays Professor Kligman to apply skin-blistering chemicals to Holmesburg Prison inmates' faces and backs, so as to, in Professor Kligman's words, "learn how the skin protects itself against chronic assault from toxic chemicals, the so-called hardening process," information which would have both offensive and defensive applications for the U.S. military (Kaye).

The CIA and Edgewood Arsenal Research Laboratories begin an extensive program for developing drugs that can influence human behavior. This program includes Project OFTEN -- which studies the toxicology, transmission and behavioral effects of drugs in animal and human subjects -- and Project CHICKWIT, which gathers European and Asian drug development information (Goliszek).

Professor Kligman develops Retin-A as an acne cream (and eventually a wrinkle cream), turning him into a multi-millionaire (Kaye).

Researchers paralyze 64 prison inmates in California with a neuromuscular compound called succinylcholine, which produces suppressed breathing that feels similar to drowning. When five prisoners refuse to participate in the medical experiment, the prison's special treatment board gives researchers permission to inject the prisoners with the drug against their will (Greger).

(1968)

Planned Parenthood of San Antonio and South Central Texas and the Southwest Foundation for Research and Education begin an oral contraceptive study on 70 poverty-stricken Mexican-American women, giving only half the oral contraceptives they think they are receiving and the other half a placebo. When the results of this study are released a few years later, it stirs tremendous controversy among Mexican-Americans (Sharav, Sauter).

(1969)

President Nixon ends the United States' offensive biowarfare program, including human experimentation done at Fort Detrick. By this time, tens of thousands of civilians and members of the U.S. armed forces have wittingly and unwittingly acted as participants in experiments involving exposure to dangerous biological agents (Goliszek).

The U.S. military conducts DTC Test 69-12, which is an open-air test of VX and sarin nerve agents at the Army's Edgewood Arsenal in Maryland, likely exposing military personnel (Goliszek, Martin).

Experimental drugs are tested on mentally disabled children in Milledgeville, Ga., without any institutional approval whatsoever (Sharav).

Dr. Donald MacArthur, the U.S. Department of Defense's Deputy Director for Research and Technology, requests $10 million from Congress to develop a synthetic biological agent that would be resistant "to the immunological and therapeutic processes upon which we depend to maintain our relative freedom from infectious disease" (Cockburn and St. Clair, eds.).

Judge Sam Steinfield's dissent in Strunk v. Strunk, 445 S.W.2d 145 marks the first time a judge has ever suggested that the Nuremberg Code be applied in American court cases (Sharav).

(1970)

A year after his request, under H.R. 15090, Dr. MacArthur receives funding to begin CIA-supervised mycoplasma research with Fort Detrick's Special Operations Division and hopefully create a synthetic immunosuppressive agent. Some experts believe that this research may have inadvertently created HIV, the virus that causes AIDS (Goliszek).

Under order from the National Institutes of Health (NIH), which also sponsored the Tuskegee Experiment, the free childcare program at Johns Hopkins University collects blood samples from 7,000 African-American youth, telling their parents that they are checking for anemia but actually checking for an extra Y chromosome (XYY), believed to be a biological predisposition to crime. The program director, Digamber Borganokar, does this experiment without Johns Hopkins University's permission (Greger, Merritte, et al.).

(1971)

President Nixon converts Fort Detrick from an offensive biowarfare lab to the Frederick Cancer Research and Development Center, now known as the National Cancer Institute at Frederick. In addition to cancer research, scientists study virology, immunology and retrovirology (including HIV) there. Additionally, the site is home to the U.S. Army Medical Research Institute, which researches drugs, vaccines and countermeasures for biological warfare, so the former Fort Detrick does not move far away from its biowarfare past (Goliszek).

Stanford University conducts the Stanford Prison Experiment on a group of college students in order to learn the psychology of prison life. Some students are given the role as prison guards, while the others are given the role of prisoners. After only six days, the proposed two-week study has to end because of its psychological effects on the participants. The "guards" had begun to act sadistic, while the "prisoners" started to show signs of depression and severe psychological stress (University of New Hampshire).

An article entitled "Viral Infections in Man Associated with Acquired Immunological Deficiency States" appears in Federation Proceedings. Dr. MacArthur and Fort Detrick's Special Operations Division have, at this point, been conducting mycoplasma research to create a synthetic immunosuppressive agent for about one year, again suggesting that this research may have produced HIV (Goliszek).

(1972)

In studies sponsored by the U.S. Air Force, Dr. Amedeo Marrazzi gives LSD to mental patients at the University of Missouri Institute of Psychiatry and the University of Minnesota Hospital to study "ego strength" (Barker).

(1973)

An Ad Hoc Advisory Panel issues its Final Report on the Tuskegee Syphilis Study, writing, "Society can no longer afford to leave the balancing of individual rights against scientific progress to the scientific community" (Sharav).

(1974)

Congress enacts the National Research Act, creating the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research and finally setting standards for human experimentation on children (Breslow).

(1975)

The Department of Health, Education and Welfare gives the National Institutes of Health's Policies for the Protection of Human Subjects (1966) regulatory status. Title 45, known as "The Common Rule," officially creates institutional review boards (IRBs) (Sharav).

(1977)

The Kennedy Hearing initiates the process toward Executive Order 12333, prohibiting intelligence agencies from experimenting on humans without informed consent (Merritte, et al.).

The U.S. government issues an official apology and $400,000 to Jeanne Connell, the sole survivor from Col. Warren's now-infamous plutonium injections at Strong Memorial Hospital, and the families of the other human test subjects (Burton Report).

The National Urban League holds its National Conference on Human Experimentation, stating, "We don't want to kill science but we don't want science to kill, mangle and abuse us" (Sharav).

(1978)

The CDC begins experimental hepatitis B vaccine trials in New York. Its ads for research subjects specifically ask for promiscuous homosexual men. Professor Wolf Szmuness of the Columbia University School of Public Health had made the vaccine's infective serum from the pooled blood serum of hepatitis-infected homosexuals and then developed it in chimpanzees, the only animal susceptible to hepatitis B, leading to the theory that HIV originated in chimpanzees before being transferred over to humans via this vaccine. A few months after 1,083 homosexual men receive the vaccine, New York physicians begin noticing cases of Kaposi's sarcoma, Mycoplasma penetrans and a new strain of herpes virus among New York's homosexual community -- diseases not usually seen among young, American men, but that would later be known as common opportunistic diseases associated with AIDS (Goliszek).

(1979)

The National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research releases the Belmont Report, which establishes the foundations for research experimentation on humans. The Belmont Report mandates that researchers follow three basic principles: 1. Respect the subjects as autonomous persons and protect those with limited ability for independence (such as children), 2. Do no harm, 3. Choose test subjects justly -- being sure not to target certain groups because of they are easily accessible or easily manipulated, rather than for reasons directly related to the tests (Berdon).

(1980)

A study reveals a high incidence of leukemia among the 18,000 military personnel who participated in 1957's Operation Plumbbob (a href="http://en.wikipedia.org/wiki/Operation_Plumbbob">"Operation Plumbob").

According to blood samples tested years later for HIV, 20 percent of all New York homosexual men who participated in the 1978 hepatitis B vaccine experiment are HIV-positive by this point (Goliszek).

American doctors give experimental hormone shots to hundreds of Haitian men confined to detention camps in Miami and Puerto Rico, causing the men to develop a condition known as gynecomastia, in which men develop full-sized breasts (Cockburn and St. Clair, eds.).

The CDC continues its 1978 hepatitis B vaccine experiment in Los Angeles, San Francisco, Chicago, St. Louis and Denver, recruiting over 7,000 homosexual men in San Francisco alone (Goliszek).

The FDA prohibits the use of prison inmates in pharmaceutical drug trials, leading to the advent of the experimental drug testing centers industry (Sharav).

The first AIDS case appears in San Francisco (Goliszek).

(1981)

(1981 - 1993) The Seattle-based Genetic Systems Corporation begins an ongoing medical experiment called Protocol No. 126, in which cancer patients at the Fred Hutchinson Cancer Research Center in Seattle are given bone marrow transplants that contain eight experimental proteins made by Genetic Systems, rather than standard bone marrow transplants; 19 human subjects die from complications directly related to the experimental treatment (Goliszek).

A deep diving experiment at Duke University causes test subject Leonard Whitlock to suffer permanent brain damage (Sharav).

The CDC acknowledges that a disease known as AIDS exists and confirms 26 cases of the disease -- all in previously healthy homosexuals living in New York, San Francisco and Los Angeles -- again supporting the speculation that AIDS originated from the hepatitis B experiments from 1978 and 1980 (Goliszek).

(1982)

Thirty percent of the test subjects used in the CDC's hepatitis B vaccine experiment are HIV-positive by this point (Goliszek).

(1984)

SFBC Phase I research clinic founded in Miami, Fla. By 2005, it would become the largest experimental drug testing center in North America with centers in Miami and Montreal, running Phase I to Phase IV clinical trials (Drug Development-Technology.com).

(1985)

A former U.S. Army sergeant tries to sue the Army for using drugs on him in without his consent or even his knowledge in United States v. Stanley, 483 U.S. 669. Justice Antonin Scalia writes the decision, clearing the U.S. military from any liability in past, present or future medical experiments without informed consent (Merritte, et al..

(1987)

Philadelphia resident Doris Jackson discovers that researchers have removed her son's brain post mortem for medical study. She later learns that the state of Pennsylvania has a doctrine of "implied consent," meaning that unless a patient signs a document stating otherwise, consent for organ removal is automatically implied (Merritte, et al.).

(1988)

The U.S. Justice Department pays nine Canadian survivors of the CIA and Dr. Cameron's "psychic driving" experiments (1957 - 1964) $750,000 in out-of-court settlements, to avoid any further investigations into MKULTRA (Goliszek).

(1988 - 2001) The New York City Administration for Children's Services begins allowing foster care children living in about two dozen children's homes to be used in National Institutes of Health-sponsored (NIH) experimental AIDS drug trials. These children -- totaling 465 by the program's end -- experience serious side effects, including inability to walk, diarrhea, vomiting, swollen joints and cramps. Children's home employees are unaware that they are giving the HIV-infected children experimental drugs, rather than standard AIDS treatments (New York City ACS, Doran).

(1990)

The United States sends 1.7 million members of the armed forces, 22 percent of whom are African-American, to the Persian Gulf for the Gulf War ("Desert Storm"). More than 400,000 of these soldiers are ordered to take an experimental nerve agent medication called pyridostigmine, which is later believed to be the cause of Gulf War Syndrome -- symptoms ranging from skin disorders, neurological disorders, incontinence, uncontrollable drooling and vision problems -- affecting Gulf War veterans (Goliszek; Merritte, et al.).

The CDC and Kaiser Pharmaceuticals of Southern California inject 1,500 six-month-old black and Hispanic babies in Los Angeles with an "experimental" measles vaccine that had never been licensed for use in the United States. Adding to the risk, children less than a year old may not have an adequate amount of myelin around their nerves, possibly resulting in impaired neural development because of the vaccine. The CDC later admits that parents were never informed that the vaccine being injected into their children was experimental (Goliszek).

The FDA allows the U.S. Department of Defense to waive the Nuremberg Code and use unapproved drugs and vaccines in Operation Desert Shield (Sharav).

(1991)

In the May 27 issue of the Los Angeles Times, former U.S. Navy radio operator Richard Jenkins writes that he suffers from leukemia, chronic fatigue and kidney and liver disease as a result of the radiation exposure he received in 1958's Operation Hardtack (Goliszek).

While participating in a UCLA study that withdraws schizophrenics off of their medications, Tony LaMadrid commits suicide (Sharav).

(1992)

Columbia University's New York State Psychiatric Institute and the Mount Sinai School of Medicine give 100 males -- mostly African-American and Hispanic, all between the ages of six and 10 and all the younger brothers of juvenile delinquents -- 10 milligrams of fenfluramine (fen-fen) per kilogram of body weight in order to test the theory that low serotonin levels are linked to violent or aggressive behavior. Parents of the participants received $125 each, including a $25 Toys 'R' Us gift certificate (Goliszek).

(1993)

Researchers at the West Haven VA in Connecticut give 27 schizophrenics -- 12 inpatients and 15 functioning volunteers -- a chemical called MCPP that significantly increases their psychotic symptoms and, as researchers note, negatively affects the test subjects on a long-term basis ("Testimony of Adil E. Shamoo, Ph.D.").

(1994)

In a double-blind experiment at New York VA Hospital, researchers take 23 schizophrenic inpatients off of their medications for a median of 30 days. They then give 17 of them 0.5 mg/kg amphetamine and six a placebo as a control, following up with PET scans at Brookhaven Laboratories. According to the researchers, the purpose of the experiment was "to specifically evaluate metabolic effects in subjects with varying degrees of amphetamine-induced psychotic exacerbation" ("Testimony of Adil E. Shamoo, Ph.D.").

Albuquerque Tribune reporter Eileen Welsome receives a Pulitzer Prize for her investigative reporting into Col. Warren's plutonium experiments on patients at Strong Memorial Hospital in 1945 (Burton Report).

In a federally funded experiment at New York VA Medical Center, researchers give schizophrenic veterans amphetamine, even though central nervous system stimulants worsen psychotic symptoms in 40 percent of schizophrenics ("Testimony of Adil E. Shamoo, Ph.D.").

Researchers at Bronx VA Medical Center recruit 28 schizophrenic veterans who are functioning in society and give them L-dopa in order to deliberately induce psychotic relapse ("Testimony of Adil E. Shamoo, Ph.D.").

President Clinton appoints the Advisory Commission on Human Radiation Experiments (ACHRE), which finally reveals the horrific experiments conducted during the Cold War era in its ACHRE Report.

(1995)

A 19-year-old University of Rochester student named Nicole Wan dies from participating in an MIT-sponsored experiment that tests airborne pollutant chemicals on humans. The experiment pays $150 to human test subjects (Sharav).

In the Mar. 15 President's Advisory Committee on Human Radiation Experiments (ACHRE), former human subjects, including those who were used in experiments as children, give sworn testimonies stating that they were subjected to radiation experiments and/or brainwashed, hypnotized, drugged, psychologically tortured, threatened and even raped during CIA experiments. These sworn statements include:

Christina DeNicola's statement that, in Tucson, Ariz., from 1966 to 1976, "Dr. B" performed mind control experiments using drugs, post-hypnotic injection and drama, and irradiation experiments on her neck, throat, chest and uterus. She was only four years old when the experiments started.

Claudia Mullen's testimony that Dr. Sidney Gottlieb (of MKULTRA fame) used chemicals, radiation, hypnosis, drugs, isolation in tubs of water, sleep deprivation, electric shock, brainwashing and emotional, sexual and verbal abuse as part of mind control experiments that had the ultimate objective of turning her, who was only a child at the time, into the "perfect spy." She tells the advisory committee that researchers justified this abuse by telling her that she was serving her country "in their bold effort to fight Communism."

Suzanne Starr's statement that "a physician, who was retired from the military, got children from the mountains of Colorado for experiments." She says she was one of those children and that she was the victim of experiments involving environmental deprivation to the point of forced psychosis, spin programming, injections, rape and frequent electroshock and mind control sessions. "I have fought self-destructive programmed messages to kill myself, and I know what a programmed message is, and I don’t act on them," she tells the advisory committee of the experiments' long-lasting effects, even in her adulthood (Goliszek).

President Clinton publicly apologizes to the thousands of people who were victims of MKULTRA and other mind-control experimental programs (Sharav).

In Dr. Daniel P. van Kammen's study, "Behavioral vs. Biochemical Prediction of Clinical Stability Following Haloperidol Withdrawal in Schizophrenia," researchers recruit 88 veterans who are stabilized by their medications enough to make them functional in society, and hospitalize them for eight to 10 weeks. During this time, the researchers stop giving the veterans the medications that are enabling them to live in society, placing them back on a two- to four-week regimen of the standard dose of Haldol. Then, the veterans are "washed-out," given lumbar punctures and put under six-week observation to see who would relapse and suffer symptomatic schizophrenia once again; 50 percent do ("Testimony of Adil E. Shamoo, Ph.D.").

President Clinton appoints the National Bioethics Advisory Committee (Sharav).

Justice Edward Greenfield of the New York State Supreme Court rules that parents do not have the right to volunteer their mentally incapacitated children for non-therapeutic medical research studies and that no mentally incapacitated person whatsoever can be used in a medical experiment without informed consent (Sharav).

(1996)

Professor Adil E. Shamoo of the University of Maryland and the organization Citizens for Responsible Care and Research sends a written testimony on the unethical use of veterans in medical research to the U.S. Senate's Committee on Governmental Affairs, stating: "This type of research is on-going nationwide in medical centers and VA hospitals supported by tens of millions of dollars of taxpayers money. These experiments are high risk and are abusive, causing not only physical and psychic harm to the most vulnerable groups but also degrading our society’s system of basic human values. Probably tens of thousands of patients are being subjected to such experiments" ("Testimony of Adil E. Shamoo, Ph.D.").

The Department of Defense admits that Gulf War soldiers were exposed to chemical agents; however, 33 percent of all military personnel afflicted with Gulf War Syndrome never left the United States during the war, discrediting the popular mainstream belief that these symptoms are a result of exposure to Iraqi chemical weapons (Merritte, et al.).

In a federally funded experiment at West Haven VA in Connecticut, Yale University researchers give schizophrenic veterans amphetamine, even though central nervous system stimulants worsen psychotic symptoms in 40 percent of schizophrenics ("Testimony of Adil E. Shamoo, Ph.D.").

President Clinton issues a formal apology to the subjects of the Tuskegee Syphilis Study and their families (Sharav).

(1997)

In order to expose unethical medical experiments that provoke psychotic relapse in schizophrenic patients, the Boston Globe publishes a four-part series entitled "Doing Harm: Research on the Mentally Ill" (Sharav).

Researchers give 26 veterans at a VA hospital a chemical called Yohimbine to purposely induce post-traumatic stress disorder ("Testimony of Adil E. Shamoo, Ph.D.").

In order to create a "psychosis model," University of Cincinnati researchers give 16 schizophrenic patients at Cincinnati VA amphetamine in order to provoke repeats bouts of psychosis and eventually produce "behavioral sensitization" (Sharav).

National Institutes of Mental Health (NIMH) researchers give schizophrenic veterans amphetamine, even though central nervous system stimulants worsen psychotic symptoms in 40 percent of schizophrenics ("Testimony of Adil E. Shamoo, Ph.D.").

In an experiment sponsored by the U.S. government, researchers withhold medical treatment from HIV-positive African-American pregnant women, giving them a placebo rather than AIDS medication (Sharav).

Researchers give amphetamine to 13 schizophrenic patients in a repetition of the 1994 "amphetamine challenge" at New York VA Hospital. As a result, the patients experience psychosis, delusions and hallucinations. The researchers claim to have informed consent ("Testimony of Adil E. Shamoo, Ph.D.").

On Sept. 18, victims of unethical medical experiments at major U.S. research centers, including the National Institutes of Mental Health (NIMH) testify before the National Bioethics Advisory Committee (Sharav).

(1999)

Adil E. Shamoo, Ph.D. testifies on "The Unethical Use of Human Beings in High-Risk Research Experiments" before the U.S. House of Representatives' House Committee on Veterans' Affairs, alerting the House on the use of American veterans in VA Hospitals as human guinea pigs and calling for national reforms ("Testimony of Adil E. Shamoo, Ph.D.").

Doctors at the University of Pennsylvania inject 18-year-old Jesse Gelsinger with an experimental gene therapy as part of an FDA-approved clinical trial. He dies four days later and his father suspects that he was not fully informed of the experiment's risk (Goliszek)

During a clinical trial investigating the effectiveness of Propulsid for infant acid reflux, nine-month-old Gage Stevens dies at Children's Hospital in Pittsburgh (Sharav).

(2000)

The Department of Defense begins declassifying the records of Project 112, including SHAD, and locating and assisting the veterans who were exposed to live toxins and chemical agents as part of Project 112. Many of them have already died (Goliszek).

President Clinton authorizes the Energy Employees Occupational Illness Compensation Act, which compensates the Department of Energy workers who sacrificed their health to build the United States' nuclear defenses (Sharav).

The U.S. Air Force and rocket maker Lockheed Martin sponsor a Loma Linda University study that pays 100 Californians $1,000 to eat a dose of perchlorate -- a toxic component of rocket fuel that causes cancer, damages the thyroid gland and hinders normal development in children and fetuses -- every day for six months. The dose eaten by the test subjects is 83 times the safe dose of perchlorate set by the State of California, which has perchlorate in some of its drinking water. This Loma Linda study is the first large-scale study to use human subjects to test the harmful effects of a water pollutant and is "inherently unethical," according to Environmental Working Group research director Richard Wiles (Goliszek, Envirnomental Working Group).

(2001)

Healthy 27-year-old Ellen Roche dies in a challenge study at Johns Hopkins University in Maryland (Sharav).

On its website, the FDA admits that its policy to include healthy children in human experiments "has led to an increasing number of proposals for studies of safety and pharmacokinetics, including those in children who do not have the condition for which the drug is intended" (Goliszek).

During a tobacco industry-financed Alzheimer's experiment at Case Western University in Cleveland, Elaine Holden-Able dies after she drinks a glass of orange juice containing a dissolved dietary supplement (Sharav).

Radiologist Scott Scheer of Pennsylvania dies from kidney failure, severe anemia and possibly lupus -- all caused by blood pressure drugs he was taking as part of a five-year clinical trial. After his death, his family sues the Institutional Review Board of Main Line Hospitals, the hospital that oversaw the study, and two doctors. Investigators from the federal Office for Human Research Protections, which is part of the Department of Health and Human Services, later conclude in a Dec. 20, 2002 letter to Scheer's oldest daughter: "Your father apparently was not told about the risk of hydralazine-induced lupus … OHRP found that certain unanticipated problems involving risks to subjects or others were not promptly reported to appropriate institutional officials" (Willen and Evans, "Doctor Who Died in Drug Test Was Betrayed by System He Trusted.")

In Higgins and Grimes v. Kennedy Krieger Institute The Maryland Court of Appeals makes a landmark decision regarding the use of children as test subjects, prohibiting non-therapeutic experimentation on children on the basis of "best interest of the individual child" (Sharav).

(2002)

President George W. Bush signs the Best Pharmaceuticals for Children Act (BPCA), offering pharmaceutical companies six-month exclusivity in exchange for running clinical drug trials on children. This will of course increase the number of children used as human test subjects (Hammer Breslow).

(2003)

Two-year-old Michael Daddio of Delaware dies of congestive heart failure. After his death, his parents learn that doctors had performed an experimental surgery on him when he was five months old, rather than using the established surgical method of repairing his congenital heart defect that the parents had been told would be performed. The established procedure has a 90- to 95-percent success rate, whereas the inventor of the procedure performed on baby Daddio would later be fired from his hospital in 2004 (Willen and Evans, "Parents of Babies Who Died in Delaware Tests Weren't Warned").

(2004)

In his BBC documentary "Guinea Pig Kids" and BBC News article of the same name, reporter Jamie Doran reveals that children involved in the New York City foster care system were unwitting human subjects in experimental AIDS drug trials from 1988 to, in his belief, present times (Doran).

(2005)

In response to the BBC documentary and article "Guinea Pig Kids", the New York City Administration of Children's Services (ACS) sends out an Apr. 22 press release admitting that foster care children were used in experimental AIDS drug trials, but says that the last trial took place in 2001 and thus the trials are not continuing, as BBC reporter Jamie Doran claims. The ACS gives the extent and statistics of the experimental drug trials, based on its own records, and contracts the Vera Institute of Justice to conduct "an independent review of ACS policy and practice regarding the enrollment of HIV-positive children in foster care in clinical drug trials during the late 1980s and 1990s" (New York City ACS).

In exchange for receiving $2 million from the American Chemical Society, the EPA proposes the Children's Health Environmental Exposure Research Study (CHEERS) to learn how children ranging from infancy to three years old ingest, inhale and absorb chemicals by exposing children from a poor, predominantly black area of Duval County, Fla., to these toxins. Due to pressure from activist groups, negative media coverage and two Democratic senators, the EPA eventually decides to drop the study on Apr. 8, 2005 (Organic Consumers Association).

Bloomberg releases a series of reports suggesting that SFBC, the largest experimental drug testing center of its time, exploits immigrant and other low-income test subjects and runs tests with limited credibility due to violations of both the FDA's and SFBC's own testing guidelines (Bloomberg).

Works cited:

Alliance for Human Research Protection. "'Monster Experiment' Taught Orphans to Stutter.". June 11, 2001.

Barker, Allen. "The Cold War Experiments." Mind Control.

Berdon, Victoria. "Codes of Medical and Human Experimentation Ethics." The Least of My Brothers.

Brinker, Wendy. "James Marion Sims: Father Butcher." Seed Show.

Burton Report. "Human Experimentation, Plutonium and Col. Stafford Warren."

Cockburn, Alexander and Jeffrey St. Clair, eds. "Germ War: The U.S. Record." Counter Punch.

"Donald Ewan [sic] Cameron." Wikipedia.

Doran, Jamie. "Guinea Pig Kids." BBC News. 30 Nov. 2004.

Drug Development-Technology.com. "SFBC."

Elliston, Jon. "MKULTRA: CIA Mind Control." Dossier: Paranormal Government.

Environmental Working Group. "U.S.: Lockheed Martin's Tests on Humans." CorpWatch.

Global Security. Chemical Corps. 2005.

Goliszek, Andrew. In the Name of Science. New York: St. Martin's, 2003.

Greger, Michael, M.D. Heart Failure: Diary of a Third Year Medical Student.

Griffiths, Joel and Chris Bryson. "Toxic Secrets: Fluoride and the Atom Bomb." Nexus Magazine 5:3. Apr. - May 1998.

Hammer Breslow, Lauren. "The Best Pharmaceuticals for Children Act of 2002: The Rise of the Voluntary Incentive Structure and Congressional Refusal to Require Pediatric Testing." Harvard Journal of Legislation Vol. 40.

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