Donald Trump will almost certainly be the Republican nominee after he defeated Ted Cruz in the Indiana primary on Tuesday night.

The news, a crippling blow to the #NeverTrump campaign, has sent many conservatives into a panic. On social media, several of them conceded the election to Hillary Clinton. One even declared that he's with Clinton, and another said America is dead.

Here are some of the reactions from leading conservatives tonight:

"You may be right, I may be crazy, but it just may be a lunatic you're looking for" turns out to have worked well as a campaign slogan. — Kristen S Anderson (@KSoltisAnderson) May 3, 2016

Congratulate the Trump supporters. Tonight will be their high point. In six months, they'll be blaming the rest of us for their choices. — Ben Shapiro (@benshapiro) May 3, 2016

Now commences six months of Trump supporters abjectly begging conservatives to take the blame for their bad decisions. — Dan McLaughlin (@baseballcrank) May 4, 2016

I don’t want to congratulate Hillary Clinton on winning the Presidency tonight, but she just did. — Erick Erickson (@EWErickson) May 3, 2016

Madam President. — Charles C. W. Cooke (@charlescwcooke) May 3, 2016

The Party Decides to Jump Off a Bridge — John Tabin (@johntabin) May 4, 2016

"It's over. 100 percent. Donald Trump will be the Republican nominee." -- 2008 McCain campaign manager Steve Schmidt — Chris Cillizza (@TheFix) May 3, 2016

If we nominate Trump, we will get destroyed.......and we will deserve it. — Lindsey Graham (@LindseyGrahamSC) May 3, 2016

America, July 4, 1776 - May 3, 2016. — Philip Klein (@philipaklein) May 3, 2016

Watch: This is how much conservatives hate Donald Trump