Other important roles for CoQ10 are for cell wall integrity and anti-oxidation. When the synthesis of CoQ10 is reduced for any reason the side effects on the body are profound. Impairment of cell membranes from CoQ10 lack plays a major role in hepatitis, myopathy, neuropathy and rhabdomyolysis.

Lack of effective anti-oxidation from CoQ10 lack exposes our mitochondria to the full effects of oxidation, contributing to a variety of mitochondrial mutations. Interference with CoQ10's vital role in energy production results in chronic fatigue and congestive heart failure.

With recent developments, resulting in a faster absorbing CoQ10, Langsjoen started a clinical trial in 2005 for severe heart failure patients, seeing dramatic results in the first volunteers. He said as Americans grow older, CoQ10 is produced less by the body. "We have known since the 1970s that patients with heart failure have low levels of coenzyme Q10 both in their blood and heart muscle. We also have known that supplemental coenzyme Q10 improves heart muscle function in patients with congestive heart failure".

"It is very important to point out that supplemental coenzyme Q10 will not benefit heart muscle function unless the blood levels of CoQ10 are high enough to enter into heart muscle and thereby improve its function."

The implication here is that "token dosing" of CoQ10 rarely helps. The dose must be therapeutic, a level that may vary from person to person.