Sen. Rob Portman Robert (Rob) Jones PortmanRomney undecided on authorizing subpoenas for GOP Obama-era probes Congress needs to prioritize government digital service delivery House passes B bill to boost Postal Service MORE (R-Ohio) does not support leadership's plan to try to repeal ObamaCare without a replacement.

“I have said consistently that I support repeal and replace, and I’m not giving up on doing both of those things. I don’t think it’s appropriate just to repeal, we’ve also got to put a replacement in place," Portman told Ohio reporters during a Tuesday conference call.

Portman is the fourth GOP senator to push back against Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellMomentum growing among Republicans for Supreme Court vote before Election Day Trump expects to nominate woman to replace Ginsburg next week Video of Lindsey Graham arguing against nominating a Supreme Court justice in an election year goes viral MORE's (R-Ky.) gambit to try to repeal ObamaCare now and give lawmakers two years to hash out a replacement.

GOP Sens. Lisa Murkowski Lisa Ann MurkowskiMomentum growing among Republicans for Supreme Court vote before Election Day Collins: President elected Nov. 3 should fill Supreme Court vacancy Barrett seen as a front-runner for Trump Supreme Court pick MORE (Alaska), Shelley Moore Capito Shelley Wellons Moore CapitoSecond GOP senator to quarantine after exposure to coronavirus GOP senator to quarantine after coronavirus exposure Hillicon Valley: Zuckerberg acknowledges failure to take down Kenosha military group despite warnings | Election officials push back against concerns over mail-in voting, drop boxes MORE (W.Va.) and Susan Collins Susan Margaret CollinsJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Trump supporters chant 'Fill that seat' at North Carolina rally Momentum growing among Republicans for Supreme Court vote before Election Day MORE (Maine) said earlier Tuesday that they would vote against proceeding to the House-passed bill being used as a vehicle for any Senate repeal action.

Portman, in comments from the call released by his office, didn't say whether he would vote against taking up the House healthcare bill.

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GOP leadership signaled Tuesday that they would try to take up the House bill, even though it appears they don't currently have the support to overcome an initial procedural hurdle.

With a slim 52-seat majority, McConnell can only afford to lose two GOP senators and still let Vice President Mike Pence Michael (Mike) Richard PenceMomentum growing among Republicans for Supreme Court vote before Election Day Sunday shows preview: Justice Ginsburg dies, sparking partisan battle over vacancy before election McConnell urges GOP senators to 'keep your powder dry' on Supreme Court vacancy MORE break a tie.

He noted that his state has been hard-hit by ObamaCare and said he hopes his colleagues will keep working toward a replacement plan that could pass.

"There’s an urgency here for Ohio, and the best approach I think is to continue to work with my colleagues in the hopes that we can come together around a replacement plan that actually works to address these problems. These are real problems and we can’t ignore them," he said.

The Senate previously passed a repeal-only bill in 2015 in a 52-47 vote, with Collins and then-Sen. Mark Kirk Mark Steven KirkLiberal veterans group urges Biden to name Duckworth VP On the Trail: Senate GOP hopefuls tie themselves to Trump Biden campaign releases video to explain 'what really happened in Ukraine' MORE (Ill.) being the only Republicans to oppose it.

But GOP lawmakers knew ahead of the vote that then-President Obama would veto the legislation.

GOP leadership initially floated repealing ObamaCare with a delayed replacement as their path forward earlier this year but had to back away amid pushback from moderates.