NEWS

6/4/15

Welcome to all of the new students joining the lab this summer! We look forward to working with you all.



5/29/15

Alejandro Cortez graduated from SJSU with a BS in Biochemistry.



4/21/15

Sarah Mullen successfully defended her thesis



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RESEARCH INTEREST

The specific and selective oxidation of an unactivated C-H bond remains one of the most challenging reactions in organic chemistry. Cytochrome P450 is a unique superfamily of heme-thiolate enzymes that catalyze the insertion of an oxygen atom, derived from molecular dioxygen, into a C-H bond of a variety of organic substrates, often with high degrees of regio- and stereoselectivity. Recent interests in these proteins arise from the desire to harness their synthetic potential for biotechnological applications.

Our laboratory focuses on developing hybrid P450 biocatalysts capable of the selective oxidation of organic substrate C-H bonds upon light activation. The hybrid enzymes consist of a photosensitizer covalently attached to P450 heme domains.

RESEARCH FUNDED BY