A man in his early 20s has been shot in the bottom at a home in Kallangur, north of Brisbane.

A neighbour ran to the man's aid after he awoke to a loud bang and screaming at about 5:00am.

"One of the neighbours was yelling for help, that he was shot and bleeding," Tim Limmer said.

"Then a car took off.

"It was a bit surreal, I didn't really know what to think."

Mr Limmer applied a towel and pressure to the wound to try to stop the blood flow.

"He lost a fair bit of blood," he said.

"But it was to the lower area of his buttocks, so I think he will be alright.

"All the neighbours are pretty close on this side of the street, so it is very out of the ordinary."

Queensland Police said the man's injuries were not life threatening.

The offender fled and is on the run.

Acting Inspector Rob Campbell said it was not yet known whether the victim knew his attacker.

"He's in good health and receiving treatment," he said.

"Our inquiries will continue with him through the day."