Group 9 metal complexes can inhibit amyloid aggregation, thought to be responsible for neurodegeneration in Alzheimer’s disease patients.

Dik-Lung Ma (University of Hong Kong) and colleagues made iridium(III) and rhodium(III) complexes that can both inhibit the aggregation of Ab 1-40 peptides and acts as luminescent probes for the peptides. Their iridium complex is the first example of a transition metal complex that displays a ‘switch-on’ luminescence response upon binding to Ab 1-40 peptides; the magnitude of response can be used to distinguish between the peptide’s monomeric and fibrillar forms.

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