Bioshock

You arrive in an Art Deco stylized city beneath the sea filled with artists that have been driven mad by a strange drug, and now you must fend off psychopaths and save strange little girls that the psychos are trying to harvest for said drugs. Or harvest them yourself for the drugs while dodging their monstrous protectors. Yeah, it's a completely unique experience and would lend itself well to the big screen, but only on a huge budget. Ironically this was set to be made until Gore Verbinski demanded a large budget and that the movie be rated R, and of course it fizzled after that. But he understood that was the only proper way to make the movie, so let's keep our fingers crossed that it happens someday.