A senior cop has lashed inattentive drivers and riders as Victoria heads for the largest spike in its road toll in living memory.

After the death of a motorcyclist on Tuesday night, Victoria's road toll now sits at 65 deaths - 27 per cent higher than the same time last year.

There have been 20 motorbike rider deaths so far this year. Credit:Rebecca Hallas

The state's toll has not risen by more than 20 per cent in a single year since 1950.

Victoria's road policing chief Doug Fryer holds "grave concerns" the 2016 trend will continue and Victoria will exceed 300 deaths for the first time since 2008.