

N-Ethyl-N-methyltryptamine (also known as Methylethyltryptamine, and MET) is a lesser-known novel psychedelic substance of the tryptamine class that produces powerful and short-lived psychedelic effects when administered. It is structurally related to DMT and is similarly unique among psychedelics due to its short-lived effects, rapid onset and progressive stages.

The fumarate salt has been reported as being active via smoking/vaporization at 15-65 mg and orally at 80-110 mg.[citation needed] When smoked or vaporized it has been reported to produce effects similar to those of DMT with some distinct stylistic variations which include a more grounded headspace, stimulating physical effects, and reduced subjective intensity.

Very little data exists about the pharmacological properties, metabolism, and toxicity of MET, and it has a very brief history of human usage. Today, it is either used recreationally or as an entheogenic substance and has been exclusively distributed by online research chemical vendors since mid-2016. Due to its unstudied properties and effects, it is highly advised to approach this novel psychedelic substance with the proper precautions and harm reduction practices if choosing to use it.

Chemistry

Generic structure of a tryptamine molecule

MET, or N-ethyl-N-methyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure that comprises a bicyclic indole heterocycle attached at R 3 to an amino group via an ethyl side chain. Unlike DMT, which contains two methyl groups, MET contains groups of one methyl and one ethyl carbon chains bound to the terminal amine R N of its tryptamine backbone.

Pharmacology

As with most psychedelic tryptamines, MET is thought to act principally as a 5-HT 2A partial agonist. The psychedelic effects are believed to come from MET's binding efficacy at the 5-HT 2A receptors. However, the role of these interactions and how they result in the psychedelic experience continue to remain elusive.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

This compound has very similar effects to that of DMT when smoked or vaporized. Its visual effects, such as geometry and internal hallucinations, are almost identical with the exception of being slightly brighter and synthetic in their overall appearance. The head space, however, has been reported to be considerably more stimulating, grounded, and less jarring than the head space of DMT, which has led some to describe it as a more recreational variant of DMT. In contrast to DMT, it also produces a noticeably pleasurable body high that is similar to that of 5-MeO-DMT although not as intensely nauseating or overwhelming.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), a literature which relies on collected anecdotal reports and the personal experiences of PsychonautWiki contributors. As a result, they should be taken with a healthy amount of skepticism. It is worth noting that these effects will not necessarily occur in a consistent or reliable manner, although higher doses (common+) are more likely to induce the full spectrum of reported effects. Likewise, adverse effects become much more likely with higher doses and may include serious injury or death.





Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational MET use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because MET is a research chemical with very little history of human usage. Anecdotal evidence from people within the community who have tried MET suggest that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

Early reports suggest MET is not habit-forming and the desire to use it can actually decrease with regular consumption. Like with most psychedelics it is most widely thought to be self-regulating.

As with DMT, tolerance to the effects of MET does not readily occur, though its extended residual effects indicate a mild form of tolerance may be present when used in quick succession. However, it presents little to no cross-tolerance with other psychedelics, meaning that after the consumption of MET psychedelics will not display a reduced effect.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

Due to its relative obscurity, the possession and sale of MET is unscheduled in most countries.

Germany : MET is controlled under the NpSG ( New Psychoactive Substances Act ) [1] as of July 18, 2019. [2] Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized. [3]

: MET is controlled under the NpSG ( ) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized. New Zealand : MET is an analogue of DMT, so is a Class C controlled substance in New Zealand. [4]

: MET is an analogue of DMT, so is a Class C controlled substance in New Zealand. Switzerland : MET is not controlled under Buchstabe A, B, C and D. It could be considered legal. [5]

: MET is not controlled under Buchstabe A, B, C and D. It could be considered legal. United Kingdom : MET is a Class A controlled substance in the UK under a generic clause originally added in 1977 that covers derivatives of tryptamine that are modified by alkyl substitution at the nitrogen atom of the tryptamine side chain. [6]

: MET is a Class A controlled substance in the UK under a generic clause originally added in 1977 that covers derivatives of tryptamine that are modified by alkyl substitution at the nitrogen atom of the tryptamine side chain. United States: MET is unscheduled in the United States. However, it is likely that it would be considered a controlled substance analogue of DMT or DET, in which case, sales for human consumption or possession with the intent to ingest could be prosecuted under the Federal Analogue Act.

See also

Discussion

References

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