“Real Housewife” Lisa Rinna is so paranoid about germs, she freaked out on a plane and wiped down the first-class cabin — including the seat in front of her — before apparently wallpapering the bathroom with toilet paper.

Rinna whipped out her sanitary wipes the moment after boarding an American Airlines flight from Philadelphia to LAX on Friday.

Much to the amusement of other passengers, the plump-lipped “Real Housewives of Beverly Hills” and “Days of Our Lives” star and wife of Harry Hamlin also offered to clean other seats around her before she appeared to start on the bathroom.

According to one fellow flier, “She is a well-known germaphobe, and once she got on the plane, whipped out a canister of sanitary wipes and cleaned down her seat, tray, everything.”

The source continued, “Then she announced if anyone else wanted their seat wiped . . . and went ahead and started cleaning the seat in front of her, screaming it was ‘disgusting!’

“When she went to the bathroom, she covered every surface with toilet paper and basically left it that way, so the next passenger had to figure out what to do with all the paper.”

Rinna, who was coming from a QVC shoot in Philadelphia, has admitted she’s a germaphobe.

She wrote on her blog in January, “Hotel rooms are gross. I’m sorry, but if you think of the who, what and where that TV changer has been, you would wipe that whole f - - king place down just like I do with my alcohol wipes . . .”

She added, “By the way, I also wipe my plane seat down and everything around me. You betcha OCD, baby, but if that keeps the bodily fluids/germs off of me, then it’s so well worth it folks!”

And in a 2015 post, she wrote, “Just recently, I have decided that upon entering my [hotel room] I must use my . . . Clorox wipes with bleach . . . Phones, remotes, handles, shower, everything!”

Her rep said, “Lisa travels a lot and wants to stay healthy. She always wipes down her airline seat, but as for the bathroom toilet, that was already covered with paper when she went in, so she just left it.”