(CNN) David Spade is remembering all the loved ones he's lost during his life -- and there have been many.

The comedian, 55, is back with a new Comedy Central show, "Lights Out With David Spade," and in a new interview discussed the success and setbacks he's faced, including the death of his sister-in-law, fashion designer Kate Spade, who died by suicide at 55 in 2018.

"I feel like Katy wouldn't have done it, five minutes later," he told The New York Times of his brother Andy's late wife, who suffered from depression and anxiety. "But these things happen and there's no going back."

He added that the designer was "so funny," but somewhat introverted.

"I don't know if agoraphobic is the word, but she didn't like to mingle a lot; she'd have people at her house and she was always so funny," Spade said.

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