Police are no longer investigating the disappearance of 22-year-old Wynnum West woman Rebecca Mackenzie, who was last seen at a Brisbane nightclub early Sunday morning.

Fortitude Valley Criminal Investigation Branch Detective Senior Sergeant Tom Armitt said police would prepare a report for the coroner.

Rebecca Mackenzie is believed to have been involved in a verbal disagreement with a male friend at the Met Nightclub on Wickham Terrace.

He said police had information to indicate the young woman was dead but were still searching for her body.

They are not treating the death as suspicious.