A gun store in Perth's southern suburbs has been robbed in the early hours of Friday morning.

Police were called to Claremont Firearms on Erceg Road in Yangebup at about 12.45am.

The drugs and firearms squad are believed to be handling the investigation.

It is believed a number of firearms were stolen but WA Police were unable to give exact figures.

Camera Icon Police at the scene of the robbery at Claremont Firearms in Yangebup. Credit: 7NEWS Perth

This is the second gun store robbery in Perth since September, when 130 weapons were stolen from Barry & Sons Firearms in Beckenham.

Anyone who has any information on the Yangebup robbery should call CrimeStoppers on 1800 333 000.