Whole-genome sequence data have been deposited in the European Genome–Phenome Archive (https://ega-archive.org); accession number EGAS00001003934. The data used from the Hartwig Medical Foundation and Genomics England databases consist of patient-level somatic variant data (annotated variant call data) and are considered privacy sensitive and available through access-controlled mechanisms. Patient-level somatic variant and clinical data were obtained from the Hartwig Medical Foundation under data request number DR-084. Somatic variant and clinical data are freely available for academic use from the Hartwig Medical Foundation through standardized procedures. Privacy and publication policies, including co-authorship policies, can be retrieved from: https://www.hartwigmedicalfoundation.nl/en/data-policy/. Data request forms can be downloaded from https://www.hartwigmedicalfoundation.nl/en/applying-for-data/. To gain access to the data, this data request form should be emailed to info@hartwigmedicalfoundation.nl, upon which it will be evaluated within six weeks by the HMF Scientific Council and an independent Data Access Board. When access is granted, the requested data become available through a download link provided by HMF. Somatic variant data from the Genomics England data set were analysed within the Genomics England Research Environment secure data portal, under Research Registry project code RR87, and exported from the Research Environment following data transfer request 1000000003652 on 3 December 2019. The Genomics England data set can be accessed by joining the community of academic and clinical scientist via the Genomics England Clinical Interpretation Partnership (GeCIP), https://www.genomicsengland.co.uk/about-gecip/. To join a GeCIP domain, the following steps have to be taken: 1. Your institution has to sign the GeCIP Participation Agreement, which outlines the key principles that members of each institution must adhere to, including our Intellectual Property and Publication Policy. 2. Submit your application using the relevant form found at the bottom of the page (https://www.genomicsengland.co.uk/join-a-gecip-domain/). 3. The domain lead will review your application, and your institution will verify your identity for Genomics England and communicate confirmation directly to Genomics England. 4. Your user account will be created. 5. You will be sent an email containing a link to complete Information Governance training and sign the GeCIP rules (https://www.genomicsengland.co.uk/wp-content/uploads/2019/07/GeCIP-Rules_29-08-2018.pdf). Completing the training and signing the GeCIP Rules are requirements for you to access the data. After you have completed the training and signed the rules, you will need to wait for your access to the Research Environment to be granted. 6. This will generally take up to one working day. You will then receive an email letting you know your account has been given access to the environment, and instructions for logging in (for more detail, see: https://www.genomicsengland.co.uk/join-a-gecip-domain/). Details of the data access agreement can be retrieved from https://figshare.com/articles/GenomicEnglandProtocol_pdf/4530893/5. All requests will be evaluated by the Genomics England Access Review Committee taking into consideration patient data protection, compliance with legal and regulatory requirements, resource availability and facilitation of high-quality research. All analysis of the data must take place within the Genomics England Research Environment secure data portal, https://www.genomicsengland.co.uk/understanding-genomics/data/ and exported following approval of a data transfer request. Regarding co-authorship, all publications using data generated as part of the Genomics England 100,000 Genomes Project must include the Genomics England Research Consortium as co-authors. The full publication policy is available at https://www.genomicsengland.co.uk/about-gecip/publications/. All other data supporting the findings of this study are available from the corresponding author upon request.