Sen. Lindsey Graham Lindsey Olin GrahamSenate GOP aims to confirm Trump court pick by Oct. 29: report The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Senate GOP sees early Supreme Court vote as political booster shot MORE (R-S.C.) called on President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE to defy subpoenas from House Democrats, calling the lawmakers “political hacks,” according to CNN.

Graham, the chair of the Senate Judiciary Committee, called on Trump to “fight like hell” against subpoenas demanding that the White House turn documents over to congressional committees.

The South Carolina Republican, who is up for re-election in 2020, told CNN that he is "OK with a politician fighting another politician," and rejected any accusations that Trump obstructed justice in special counsel Robert Mueller Robert (Bob) MuellerCNN's Toobin warns McCabe is in 'perilous condition' with emboldened Trump CNN anchor rips Trump over Stone while evoking Clinton-Lynch tarmac meeting The Hill's 12:30 Report: New Hampshire fallout MORE's investigation.

"Obstruction of justice to me is absurd because the President cooperated fully," Graham told CNN. "So if the House wants to keep doing this, if I were the President I'd fight like hell."

"The Mueller report is the last and final word on everything (about) Trump's campaign for me," he added.

Mueller noted in his report on his investigation into Russian interference in the 2016 election that the evidence did not find Trump committed a crime, but that it did not fully exonerate him on the question of obstruction of justice.

House Democrats are ramping up efforts to continue investigating Trump on obstruction, noting that Mueller' detailed 10 episodes related to alleged obstruction that were subject to his team's scrutiny. Trump said last week that he would fight "all the subpoenas" issued by the House, arguing that his cooperation with Mueller's investigation was sufficient.

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CNN also asked Graham about his past comments during the impeachment of former President Bill Clinton William (Bill) Jefferson ClintonEpstein podcast host says he affiliated with elites from 'both sides of the aisle' Ruth Bader Ginsburg lies in repose at Supreme Court Business groups start gaming out a Biden administration MORE.

Graham, who was then a member of the House Judiciary Committee, said in 1998 that former President Richard Nixon became subject to impeachment when he “failed” to answer a subpoena, “because he took the power … over the impeachment process away from Congress."

When CNN asked him about the quote, Graham responded “I said that?” and added that the situations were not analogous because Nixon had defied subpoenas from special prosecutor Leon Jaworski, not Congress.

"Their guys are political hacks right now," Graham said. "Mueller was the guy I was looking to -- not Nadler, not Lindsey Graham, not any of us, not a Republican."

In 1998, Graham voted for an article of impeachment charging Clinton with “impair[ing] the due and proper administration of justice” and saying he “refused and failed to respond to certain written requests for admission and willfully made perjurious, false and misleading sworn statements.”

In the CNN interview, Graham denied he was partisan in his view of impeachment, noting he was the only Republican to vote against any of the articles of impeachment against Clinton, breaking with his party on an impeachment article related to alleged lying in a civil case.