A Brisbane bank worker who crashed his car into the garage of his ex-girlfriends home southwest of Brisbane before dousing the house in fuel and setting it alight has died in hospital.

Neil de Graaf, 37, drove his new BMW into the garage of the property on Birchwood Road, Brookwater, about 7.30pm on Monday night.

He suffered burns to 95 percent of his body and was taken to hospital in a critical condition, but succumbed to his injuries overnight.

Police believe the incident was a case of domestic violence.

During the incident, de Graff's 23-year-old de facto partner, April Lane, her 48-year-old mother and two 18-year-olds locked themselves in the home’s bathroom before making a miraculous escape.

"The occupants inside the bathroom have manged to force themselves out of the house and out onto the front yard," Queensland Police's Heath McQueen told 9NEWS.

"We're very fortunate that we're not standing here with a much worse situation... there could have been multiple persons deceased as a result of the incident last night."

Ms Lane's mother suffered minor burns and has since been discharged from hospital.

A man has received burns to 90 percent of his body in a suspected domestic violence incident. (9NEWS)

Two firefighters were also injured when the roof caved in.

Ipswich City Council's Paul Tully said the house was "engulfed in flames" when he arrived.

Firefighters also saved a dog from inside the home, and it has since been taken to a shelter.

A neighbour in the street told 9NEWS they heard yelling nearby shortly before the crash.