He was diagnosed with a virulent former of brain cancer in July 2017, a week after d

McCain survived nearly six years as a POW in North Vietnam, succeeded Barry Goldwater in the Senate and lost a White House bid to Barack Obama.

Sen. John McCain, who survived nearly six years as a prisoner of war in North Vietnam, succeeded Barry Goldwater to represent Arizona in the Senate, lost a White House bid to freshman Sen. Barack Obama and became an outspoken critic of President Donald Trump, has died. He was 81. McCain died Saturday. His office released this statement: Senator John Sidney McCain III died at 4:28pm on August 25, 2018. With the Senator when he passed were his wife Cindy and their family. At his death, he had served the United States of America faithfully for sixty years. Later, Cindy McCain took to Twitter to honor her husband. "My heart is broken. I am so lucky to have lived the adventure of loving this incredible man for 38 years," she tweeted. "He passed the way he lived, on his own terms, surrounded by the people he loved, in the the place he loved best." Daughter Meghan McCain posted a tribute to her father on social media, as well. Meghan McCain tweet McCain was diagnosed in July 2017 with glioblastoma, a virulent brain cancer, a week after doctors removed a blood clot from above his left eye. He underwent surgery for an intestinal infection in April 2018. On Aug. 24, five days before his 82nd birthday, his family announced that "with his usual strength of will, he has now chosen to discontinue medical treatment. "Our family is immensely grateful for the support and kindness of all his caregivers over the last year, and for the continuing outpouring of concern and affection from John's many friends and associates, and the many thousands of people who are keeping him in their prayers," the family said. "God bless and thank you all." During his 3½-decade congressional career, McCain was a conservative who rejected Republican orthodoxy, earning him the label "maverick." He backed campaign finance reform to limit corporate donations to candidates and was a leader in efforts to normalize relations with Vietnam. He voted against a bill to make Martin Luther King's birthday a federal holiday but backed legislation to support his Native American constituents, including the 1988 Indian Gaming Regulatory Act, which opened the way for tribal casino development. And he was a thorn in the side of fellow Republican Trump, who expressed his "deepest sympathies to McCain's family about his passing. Trump tweet: My deepest sympathies and respect go out to the family of Senator John McCain. Our hearts and prayers are with you! Ever the fighter, McCain had promised to return to Washington soon after the cancer diagnosis. McCain tweet His treatment forced him to miss the Senate vote on the GOP tax overhaul in December 2017. But nearly two weeks after surgery in July 2017, he marched into the Senate to a standing ovation and cast the deciding vote that killed the Senate GOP's "skinny" bill to repeal Obamacare — at 1:29 a.m. He joined with Republican Sens. Lisa Murkowski of Alaska and Susan Collins of Maine and 48 Democrats. "I thought it was the right thing to do," he said afterward. Tweet "From the beginning, I have believed that Obamacare should be repealed and replaced with a solution that increases competition, lowers costs, and improves care for the American people. The so-called 'skinny repeal' amendment the Senate voted on today would not accomplish those goals," McCain said in a statement. "We must do the hard work our citizens expect of us and deserve."

Sen. John McCain makes his way to a meeting on the tax bill in the Senate, Dec. 1, 2017. Bill O'Leary | The Washington Post | Getty Images

Sen. John McCain announces his opposition to the "skinny repeal" of Obamacare, July 27, 2017. Getty Images

Two runs for the White House

McCain's Senate tenure began in 1987, when he succeeded the retiring Goldwater, the GOP's 1964 presidential candidate. In McCain's 2008 run for the White House, he made a "Hail Mary" pick for a running mate, Alaska Gov. Sarah Palin, in hopes that a woman on the ticket would energize his flagging campaign. Obama won by 53 to 46 percent. McCain had considered independent Sen. Joe Lieberman as his running mate. Aides advised against it because Lieberman, who was Al Gore's running mate in their failed 2000 race against George W. Bush and Dick Cheney, still caucused with the Democrats and supported abortion rights. "It was sound advice that I could reason for myself," McCain said in his memoir "The Restless Wave," published in May 2018. "But my gut told me to ignore it and I wish I had." Palin tweeted a tribute to McCain on Saturday night. "John McCain was my friend. I will remember the good times. My family and I send prayers for Cindy and the McCain family," the former vice presidential nominee wrote. McCain also ran in 2000, winning only Arizona and six other states in his bid for the GOP nomination that was won by Bush. Bush paid tribute to McCain on Saturday, not long after the senator's death was announced. "Some lives are so vivid, it is difficult to imagine them ended. Some voices are so vibrant, it is hard to think of them stilled. John McCain was a man of deep conviction and a patriot of the highest order," the former president said in a statement. "He was a public servant in the finest traditions of our country. And to me, he was a friend whom I'll deeply miss." A hawk on foreign policy, McCain became chairman of the Senate Armed Services Committee after Republicans took control of the chamber in 2015. He made his first foray into politics in 1982 by winning the seat left vacant by the retirement of House Minority Leader John Rhodes. McCain served two terms before being elected to the Senate. In the late 1980s, he was one of the "Keating Five" senators accused of improperly intervening on behalf of Phoenix savings and loan executive Charles Keating in an investigation by the Federal Home Loan Bank Board. McCain, whose campaigns had received $112,000 in donations from the S&L executive, sat in on two meetings with the regulators in the Keating matter. After an extensive investigation by the Senate Ethics Committee, McCain was exonerated in 1991 but reprimanded for using "poor judgment." ''It was a searing experience for John,'' attorney John Dowd, who represented him during the ethics inquiry (and later served nine months as Trump's lawyer in the probe of Russian meddling in the 2016 presidential campaign), told The New York Times in 1999. ''He told me it was worse than being in Hanoi.'' The son and grandson of four-star admirals, John Sidney McCain III was born Aug. 29, 1936, at a Navy air station in the Panama Canal Zone. He graduated from the U.S. Naval Academy in 1958, was commissioned as an ensign and became a Navy aviator.

Surviving the 'Hanoi Hilton'

McCain was an A-4 Skyhawk pilot stationed on the USS Forrestal when the aircraft carrier caught fire off Vietnam on July 29, 1967 — its fifth day of combat duty — killing 134 servicemen. During a bombing run over Hanoi five months later, he was shot down, parachuting into a lake. While ejecting from the plane flying at 575 mph, he was knocked unconscious, breaking a knee and both arms, according to his account published in U.S. News & World Report. After being dragged out of the lake by the North Vietnamese, he recalled, he survived a mob attack and was taken to the Hoa Lo Prison — derisively dubbed the Hanoi Hilton. After being interrogated, beaten and bayoneted in a foot, he was denied medical care until his captors found out he was the son of an admiral. They took him to a hospital.

After his plane was shot down, McCain is pulled out of a Hanoi lake by North Vietnamese soldiers and civilians in this October 1967 file photo. Reuters

"I woke up a couple of times in the next three or four days," McCain wrote. "Plasma and blood were being put into me. I became fairly lucid. I was in a room which was not particularly small — about 15 by 15 feet — but it was filthy dirty and at a lower level, so that every time it rained, there'd be about a half inch to an inch of water on the floor. I was not washed once while I was in the hospital. I almost never saw a doctor or a nurse." He was held until 1973, including more than two years in solitary confinement. He estimated that at one point during his captivity, his weight had dropped to 105 pounds. "I thought a lot about the meaning of life," he said in his U.S. News recollection written in 1973. "As prisoners of war in North Vietnam, deprived of all liberty, we relied on three things: faith in God, faith in our country, and faith in each other," McCain wrote in the forward to the 2017 book "Six Years in the Hanoi Hilton" by Amy Shively Hawk, daughter of POW James Shively. "Reliance on those three ideologies forged within us a special unity and loyalty. Forty-two years later, those I love most and best in the world are men I spent time with in prison." He returned to Vietnam several times, first in 1985 to commemorate the 10th anniversary of the end of the war, and in April 2000 to mark the 25th anniversary. Referring to the prison guards, he told The New York Times during that visit: ''I still bear them ill will, ... not because of what they did to me, but because of what they did to some of my friends — including killing some of them.''

'I have faced tougher adversaries'

Before the July 28 vote against the Obamacare repeal, McCain's absence from Washington due to the brain surgery at the Mayo Clinic in Phoenix helped set back the Republicans' previous attempt to repeal and replace Obama's Affordable Care Act, given the GOP's tiny edge in the Senate. He also announced his opposition to a last-ditch third GOP attempt to repeal the act in September, saying "I believe we could do better working together, Republicans and Democrats and have not yet really tried. Nor could I support it without knowing how much it will cost, how it will affect insurance premiums, and how many people will be helped or hurt by it." That announcement prompted Trump to blame him for the GOP failure to repeal Obamacare. "You can call it what you want, but that's the only reason we don't have it, because of John McCain," Trump said in September 2017 on the "Rick and Bubba" radio show, which airs in the South. Receiving the Liberty Medal at the National Constitution Center in Philadelphia the next month, McCain took issue with the nationalist and isolationist policies that Trump campaigned on to win the White House. Without mentioning Trump by name, McCain said: "To fear the world we have organized and led for three-quarters of a century, to abandon the ideals we have advanced around the globe, to refuse the obligations of international leadership and our duty to remain 'the last best hope of earth' for the sake of some half-baked, spurious nationalism cooked up by people who would rather find scapegoats than solve problems is as unpatriotic as an attachment to any other tired dogma of the past that Americans consigned to the ash heap of history." Trump responded in an interview with Washington's WMAL radio, saying: "I'm being very, very nice, but at some point I fight back and it won't be pretty." To which McCain replied: "I have faced tougher adversaries." People close to the senator informed the White House that McCain wanted Vice President Mike Pence, but not Trump, to attend his funeral.

'This guy, he served his country'