The union representing nearly half a million UK nurses has written to Theresa May, Jeremy Corbyn and major party leaders asking them to agree to a Final Say on the terms of leaving the EU.

Failure to secure a deal poses an immediate threat to the public’s health and will “severely impact” nurses’ and midwives’ ability to provide safe care, the Royal College of Nursing (RCN) said on Wednesday.

More than 715,000 people have already backed The Independent’s Final Say campaign calling on Theresa May to accept a second vote to ensure key issues are solved before leaving, and avoid crashing out without a deal.

The endorsement by the RCN today comes after its members voted in favour of a second referendum in May and the campaign has been backed by the doctors of the British Medical Association, and leading politicians of all stripes.

With more than 100,000 staff vacancies across the NHS, 40,000 of them nurses, the RCN has been vocal about the harms of a “botched Brexit” and the risk of making it more difficult to attract nurses.

It says a second referendum will ensure the public has the chance to make an informed decision on the terms of the UK’s exit, two and a half years after it voted to leave.

In the letter RCN chair of council Maria Trewern warns that as well as staff numbers Brexit has particular problems for the health service in Northern Ireland and the Republic of Ireland if it leads to a hard border being reintroduced.

Ms Trewern said: “As the debate across our membership has made clear, the implications of Brexit for the health and care system will be numerous.

“There are risks that, if not credibly addressed, may damage population health, as well as severely impact on our members’ ability to provide safe and effective care for their patients in both the short and the long term.

People's Vote march – demanding vote on final Brexit deal Show all 30 1 /30 People's Vote march – demanding vote on final Brexit deal People's Vote march – demanding vote on final Brexit deal Mandatory Credit: Photo by Guy Bell/REX (9725259aq) Marching down Whitehall - People's March for a People's Vote on the final Brexit deal. Timed to coincide with the second anniversary of the 2016 referendum it is organised by anti Brexit, pro EU campaigners. People's March for a People's Vote, London, UK - 23 Jun 2018 Guy Bell/REX Rex People's Vote march – demanding vote on final Brexit deal Demonstrators carry banners and flags as they participate in the People's March demanding a People's Vote on the final Brexit deal, in central London on June 23, 2018, the second anniversary of the 2016 referendum. Tens of thousands of people demonstrated in London on Saturday calling for a second vote on Britain's departure from the European Union. / AFP PHOTO / Niklas HALLE'NNIKLAS HALLE'N/AFP/Getty Images NIKLAS HALLE'N AFP/Getty Images People's Vote march – demanding vote on final Brexit deal A young protestor shouts as she takes part in the People's Vote demonstration against Brexit Getty Images People's Vote march – demanding vote on final Brexit deal A woman holds a placard as she joins EU supporters, calling on the government to give Britons a vote on the final Brexit deal, participating in the 'People's Vote' march in central London, Britain June 23, 2018. REUTERS/Henry Nicholls HENRY NICHOLLS Reuters People's Vote march – demanding vote on final Brexit deal epa06833888 Pro-EU demonstrators take part in a People's March anti-Brexit rally in Parliament Square in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal A protester's pro-EU t-shirt EPA People's Vote march – demanding vote on final Brexit deal epa06833892 A pro-EU demonstrator waves a European Flag during a People's March anti-Brexit rally in Parliament Square in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Demonstrators carry banners and flags as they participate in the People's March demanding a People's Vote on the final Brexit deal, in central London on June 23, 2018, the second anniversary of the 2016 referendum. Tens of thousands of people demonstrated in London on Saturday calling for a second vote on Britain's departure from the European Union. / AFP PHOTO / Niklas HALLE'NNIKLAS HALLE'N/AFP/Getty Images NIKLAS HALLE'N AFP/Getty Images People's Vote march – demanding vote on final Brexit deal epa06833960 Tens of thousands of people march through London during a People's March anti-Brexit demonstration in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Leader of the Liberal Democrats, Vince Cable speaks during the People's March demanding a People's Vote on the final Brexit deal, in central London on June 23, 2018, the second anniversary of the 2016 referendum. Tens of thousands of people demonstrated in London on Saturday calling for a second vote on Britain's departure from the European Union. / AFP PHOTO / Niklas HALLE'NNIKLAS HALLE'N/AFP/Getty Images NIKLAS HALLE'N AFP/Getty People's Vote march – demanding vote on final Brexit deal epa06833964 A young pro-EU demonstrator takes part in a People's March anti-Brexit rally in Parliament Square in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Gina Miller and Caroline Lucas EPA People's Vote march – demanding vote on final Brexit deal epa06834044 Tens of thousands of people march through London during a People's March anti-Brexit demonstration, in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal epa06833264 Thousands of people march through London during a People's March anti Brexit demonstration in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Tens of thousands of people march through London EPA People's Vote march – demanding vote on final Brexit deal epa06833265 Thousands of people march through London during a People's March anti Brexit demonstration in London, Britain, 23 June 2018. Protesters are calling for a referendum on the final deal. The protest is taking place on the second anniversary of the Brexit referendum. EPA/ANDY RAIN ANDY RAIN EPA People's Vote march – demanding vote on final Brexit deal Demonstrators at the People's Vote March Getty People's Vote march – demanding vote on final Brexit deal 'Two months too young to decide on my future' REUTERS People's Vote march – demanding vote on final Brexit deal Crowds taking part in the People's Vote march for a second EU referendum at Trafalgar Square in central London. PRESS ASSOCIATION Photo. Picture date: Saturday June 23, 2018. See PA story POLITICS Brexit. 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PRESS ASSOCIATION Photo. Picture date: Saturday June 23, 2018. See PA story POLITICS Brexit. Photo credit should read: John Stillwell/PA Wire John Stillwell PA People's Vote march – demanding vote on final Brexit deal Crowds gather on Pall Mall PA People's Vote march – demanding vote on final Brexit deal A man resembling Britain's Foreign Secretary Boris Johnson, joins EU supporters Reuters People's Vote march – demanding vote on final Brexit deal EU supporters, calling on the government to give Britons a vote on the final Brexit deal, participate in the 'People's Vote' march in central London, Britain June 23, 2018. REUTERS/Henry Nicholls HENRY NICHOLLS Reuters People's Vote march – demanding vote on final Brexit deal People gather in Trafalgar Square REUTERS People's Vote march – demanding vote on final Brexit deal Pro-EU campaigner Gina Miller and Tony Robinson PA People's Vote march – demanding vote on final Brexit deal EU supporters, calling on the government to give Britons a vote on the final Brexit deal, participate in the 'People's Vote' march REUTERS

“We have written to all political parties in these terms, as well as publicly shared the content of this letter.”

The letter was also sent to Vince Cable, Caroline Lucas and Jonathan Bartley; Ian Blackford, the SNP’s Westminster leader; Plaid Cymru’s Leanne Wood, the DUP’s Arlene Foster, and Sinn Fein’s Michelle O’Neil.

Ms Trewern added the union will step up its campaigning for a second referendum in the coming months.

However Theresa May has ruled out a second referendum, and a spokesperson for No 10 said today: “The British public have voted to leave the European Union.