That’s one of Sean Trende’s eight takeaways from Iowa:

Joe Biden is on life support. We shouldn’t mince words here: Biden had an awful night. Yes, Iowa is a heavily white state, and it is a caucus rather than a primary, so it didn’t play to his strengths. Nevertheless, Biden is a former vice president to a very popular ex-president. He has universal name recognition and the implicit backing of large swaths of the Democratic establishment.

Yes, he can still recover in South Carolina, although that is looking much less probable than it did Monday morning. If his African-American support remains solid, he will perform well in the South. But his weakness among Northern whites is a red flag for states where he will need to win — and where he can’t rely on African-American support to push him over the top. If he’s coming in fourth place in Iowa, delegate-rich states like Wisconsin, Michigan, Illinois, and Ohio are likely to be challenging for him as well.