Jerusalem (CNN) Four Palestinians were killed and hundreds wounded Friday in the West Bank and Gaza during violent clashes between Israeli troops and protesters opposed to US President Donald Trump's recognition of Jerusalem as the capital of Israel.

Roughly 2,500 Palestinians rolled burning tires and hurled firebombs and rocks at police in several West Bank cities, and another 3,500 clashed with soldiers along the security fence in Gaza, the Israeli army said.

Israeli forces confront Palestinian protesters in Jerusalem's Old City on Friday.

The Palestinian Health Ministry said two people were killed in Gaza, both of them shot in the head. The ministry identified them as Yaser Sukar, 23, killed in Shujaiyya, east of Gaza City; and Ibrahim Abu Tharaya, 29, shot during clashes along Gaza's border with Israel.

Tharaya was a wheelchair-bound double amputee, the ministry said. He was regularly photographed at protests in Gaza waving a Palestinian flag from his wheelchair.

"Throughout yesterday extremely violent riots erupted along the border of the Gaza strip," the Israel Defense Forces said in a statement. "IDF troops fired selectively towards main instigators. Claims were received about two dead Palestinians. The claims regarding the circumstances of the death of a Palestinian with no legs who participated in the riots will be reviewed."

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