ORCHARD PARK, N.Y. -- The Buffalo Bills declared running back Karlos Williams (shoulder) out for Sunday’s game against the Houston Texans after the rookie missed all three practices this week.

Williams, who injured his shoulder early in the Bills’ loss to the Kansas City Chiefs last Sunday, was wearing a sling in the locker room until Friday.

The Bills will be without rookie RB Karlos Williams, who has five rushing touchdowns this season. Kevin Hoffman/USA TODAY Sports

Williams’ injury leaves LeSean McCoy and Boobie Dixon as the only two healthy running backs on the Bills’ 53-man roster. Coach Rex Ryan said Friday that the team will promote former University of Florida running back Mike Gillislee from their practice squad before Sunday’s game.

Williams, a fifth-round pick from Florida State, ranks sixth among NFL rookie running backs with 376 rushing yards this season. He ranks third with five rushing touchdowns.

The Bills also declared linebacker Nigel Bradham (ankle) and starting right guard John Miller (ankle) as out for Sunday’s game and listed starting right tackle Seantrel Henderson (illness) as doubtful, although Ryan said Henderson is “very doubtful” for the game.

Rookie Tony Steward will make his first career start in place of Bradham, veteran Kraig Urbik will start in place of Miller, and Jordan Mills will likely start for Henderson.