A paramedic has died after an ambulance crashed in north Queensland on Monday morning, with the 32-year-old man's death described as "one of the saddest days in the history of the Queensland Ambulance Service".

Emergency crews were called to Mackay-Eungella Road in Benholme, west of Mackay, around 8:00am after reports the ambulance vehicle had left the road, rolled several times and hit a tree.

The man was the only occupant and was responding to a code-1 emergency at the time of the crash.

QAS Acting Deputy Commissioner Gerard Lawler said the officer could not be saved.

"Despite the best efforts of the bystanders before other emergency services arrived, and the efforts of paramedics and fire services officers, the officer unfortunately died at the scene," he said.

"Circumstances like this, when we are attending one of our own, are the most challenging circumstances that a paramedic or emergency services officer will do in their day-to-day duties."

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Acting Deputy Commissioner Lawler said the man was an experienced advanced care paramedic who was highly respected in his field.

"The officer had worked within the ambulance service for about nine or 10 years," he said.

"He was a very diligent, professional officer who cared for his community — It's our most tragic day."

Support is being provided to the man's colleagues and the first responders.

The QAS Legacy Scheme said in a social media post it was offering support to the paramedic's family.

"With deep regret we have been notified of the death of a QAS officer while responding to a case [Monday] morning," the post read.

"We will be contacting the family at an appropriate time to offer the support of the QAS Legacy Scheme."

It said people could donate directly to the QAS Legacy Scheme if they wished to help support the officer's family.