Gregg “Opie” Hughes, one-half of XM Satellite Radio’s “The Opie and Anthony Show,” is opening an American fusion bistro in downtown Huntington.

The eatery, F.H. Riley’s, is co-owned by Brett Hughes, Opie’s younger brother, an executive chef and hospitality veteran, who most recently served as chef at Mim’s in Syosset and Roslyn.

It’s the first such venture for Opie, 40, and Brett, 36.

“I’m doing it for my brother,” Opie said. Brett’s been in the business since he was 15 years old. “It’s time for him to open his own place.”

The 2,200-square-foot restaurant, at 400 New York Ave., will seat 70 people.

Debuting on Jan. 31, the restaurant will feature cuisine with Cajun, Asian and Spanish influences, Brett said. Entrees include chopped salads, steak, and fish priced between $8 and $25.

Opie plans to broadcast the radio show from F.H. Riley’s “from time to time,” though no dates are confirmed yet.

“It’s a place I’ll be hanging out in,” said Opie, who has already talked about the restaurant on his show.

Opie said the show has more than 1 million listeners. Though an XM Satellite Radio spokeswoman would not disclose the number of listeners for individual shows, she said the company has more than 6 million subscribers.

Satellite radio is known for attracting national audiences. However, Opie said, “Our show has a huge local following.” He added that it takes ads for local businesses.

Additionally, the restaurant will place ads in the local press, and plans to partner with the Huntington Arts Council to feature the work of local artists.

The eatery’s name honors two family members. F.H. is for Frederick Hughes, Opie and Brett’s father, who died last year from a “horrific” car crash he endured as a backseat passenger outside his Centerport home. Riley is Opie and Brett’s 2-year-old niece, the last person Frederick held before the accident.

Back then, “I was working 80 to 90 hours a week. I had no time to talk to my dad. I’d spent the entire time working for someone else,” Brett said. The accident “was a big eye opener.” Brett became determined to open a restaurant, something Fred had always encouraged.

He spent a year scouting sites, until he found this location.

Though requests to discuss investment were declined, Opie said he’s “committed” to becoming a fixture.

On weekends, the restaurant will occasionally feature local and national comedians and acoustical music entertainment. Most shows, Brett said, would be for “private parties,” with “personal invites” during “after hours.”

Brett did not think the entertainment would compete with Inter-Media Art Center, a 500-seat theater a block away.

Local proprietors say F.H. Riley’s will be good for business.

“We are happy to have him next door,” said John J. Tunney, an owner of Blue Honu. “With his radio connections, I am sure we will all benefit from the radio exposure that will be brought to the new restaurant.”

Added Roberto Ornato, owner of Jonathan’s Ristorante, “Any new business coming into the community with a celebrity owner can only help draw more attention to the area which I believe will ultimately benefit my business as well.”