The show Frasier ended in 2004 but two of its main stars still stirred up laughter when they got together on Friday for a reunion.

Kelsey Grammer, 60, and David Hyde Pierce, 56, reunited on Access Hollywood Live at the Rockefeller Plaza in New York City.

On location with presenters Billy Bush and Kit Hoover, the two former on screen brothers went head-to-head in a trivia game.

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Reunited: Kelsey Grammer, 60, and David Hyde Pierce, 56, reunited on Access Hollywood Live at the Rockefeller Plaza in New York City on Friday

The two actors spent 11 seasons playing bickering brothers who were both doctors on the TV show comedy.

Grammer portrayed protagonist Dr. Frasier Crane, while Pierce played his younger brother Dr. Niles Crane.

And while they argued on-screen, the pair have always got on very well in real life.

Showtime: The former co-stars were accompanied by host presenters Billy Bush and Kit Hoover

Oh the memories: They played a game called 'Who Said That?' where they had to guess which selected line belonged to which of their two characters

Access Hollywood Live's two hosts presented the reunited actors with a trivia game called Who Said That?

After hearing a line from one of their critically acclaimed episodes, they had to decide which of their characters it belonged to.

It took three questions to warm up before the pair went on a small winning streak - however that lasted briefly and they both finished having humorously answered less than half of the questions correctly.

Back in the day: The actor's played brothers who often bickered and were both doctors on the show

Whole cast: The main crew from the back row left to right is Kelsey Grammer as Doctor Frasier Crane, David Hyde Pierce as Doctor Niles Crane, Dan Butler as Bob 'Bulldog' Briscoe. Front left to right is John Mahoney as Martin Crane, Jane Leeves as Daphne Moon, Peri Gilpin as Roz Doyle

'You know, we're sort of interchangeable,' Grammer laughed after missing one of the questions.

The two actors, who admit that they catch up every few months over dinner, were in sync with their hilarious answers - whether right or wrong.

One of the trivia lines chosen by Access Hollywood Live was, 'I need to ask a small favor, I need you to create a distraction while I have a sex-change and move to Europe.'

Both of the retired actors were baffled as to who may have said the line, so the hosts suggested that Pierce read it aloud.

Hit and miss: The actors answered incorrectly for the first three trivia questions, and improved as the game continued

Good times: The show aired in 1993 and reached 11 seasons in total before ending in 2004

He did so using a faster pace of speaking - the way that his character Niles would have sounded -and the crowd burst into nostalgic laughter.

The final But the final score came to three points for Grammer and four for Pierce .

May 13 will mark 11 years since the Frasier series finale ended, while it will be 22 years since the show began in September.

Grammer and Pierce also discussed their current projects. While Grammer plays Captain Hook in Finding Neverland, Pierce is directing It Shoulda Been You.