Author notes

Kari E. North, Erik Ingelsson, Joel N. Hirschhorn, Ruth J. F. Loos and Elizabeth K. Speliotes: These authors jointly supervised this work.

Adam E. Locke, Bratati Kahali, Sonja I. Berndt, Anne E. Justice and Tune H. Pers: These authors contributed equally to this work.

Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, 48109, Michigan, USA Adam E. Locke, Jennifer L. Bragg-Gresham, Anne U. Jackson, Heather M. Stringham, Gonçalo R. Abecasis & Michael Boehnke

Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, 48109, Michigan, USA Bratati Kahali, Corey Powell & Elizabeth K. Speliotes

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA Sonja I. Berndt, Zhaoming Wang, Kevin B. Jacobs & Stephen J. Chanock

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. Anne E. Justice, Keri L. Monda & Kari E. North

Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, 02115, Massachusetts, USA Tune H. Pers, Sailaja Vedantam, Tonu Esko, Cameron D. Palmer, Rany M. Salem & Joel N. Hirschhorn

Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, 02142, Massachusetts, USA Tune H. Pers, Sailaja Vedantam, Tonu Esko, Cameron D. Palmer, Karol Estrada, Robert E. Handsaker, Sekar Kathiresan, Steven A. McCarroll, Rany M. Salem, Cecilia M. Lindgren & Joel N. Hirschhorn

Department of Genetics, Harvard Medical School, Boston, 02115, Massachusetts, USA Tune H. Pers, Tonu Esko, Robert E. Handsaker, Steven A. McCarroll, Rany M. Salem & Joel N. Hirschhorn

Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby 2800, Denmark. Tune H. Pers

MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. Felix R. Day, Jian’an Luan, Jing Hua Zhao, Robert A. Scott, Nita G. Forouhi, Claudia Langenberg, Ken K. Ong, Nicholas J. Wareham & Ruth J. F. Loos

Department of Genetics, University of North Carolina, Chapel Hill, 27599, North Carolina, USA Martin L. Buchkovich, Damien C. Croteau-Chonka & Karen L. Mohlke

Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia. Jian Yang, Anna A. E. Vinkhuyzen & Peter M. Visscher

The University of Queensland Diamantina Institute, The Translation Research Institute, Brisbane 4012, Australia. Jian Yang & Peter M. Visscher

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, Massachusetts, USA Damien C. Croteau-Chonka, Lu Qi & David J. Hunter

Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. Tonu Esko, Reedik Mägi, Krista Fischer, Toomas Haller, Evelin Mihailov, Lili Milani, Eva Reinmaa, Andrew P. Morris, Mari Nelis, Andres Metspalu & Markus Perola

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden. Tove Fall, Henrik Grönberg, Per Hall, Patrik K. E. Magnusson & Nancy L. Pedersen

Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden. Tove Fall, Stefan Gustafsson, Åsa K. Hedman, Johan Ärnlöv, Ann-Christine Syvänen & Erik Ingelsson

Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala 75185, Sweden. Tove Fall, Stefan Gustafsson, Åsa K. Hedman, Johan Ärnlöv & Erik Ingelsson

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Teresa Ferreira, Reedik Mägi, Joshua C. Randall, Åsa K. Hedman, Anuj Goel, Inga Prokopenko, Thorhildur Juliusdottir, Anubha Mahajan, Nigel W. Rayner, Neil R. Robertson, Alexander W. Drong, Sarah Keildson, John R. B. Perry, Krina T. Zondervan, Martin Farrall, Andrew P. Morris, Hugh Watkins, Mark I. McCarthy, Cecilia M. Lindgren & Erik Ingelsson

Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland. Zoltán Kutalik

Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland. Zoltán Kutalik & Jacques S. Beckmann

Department of Medical Genetics, University of Lausanne, Lausanne 1005, Switzerland. Zoltán Kutalik & Jacques S. Beckmann

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. Joshua C. Randall, Nigel W. Rayner, Kathleen Stirrups, Panos Deloukas & Inês Barroso

Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany. Thomas W. Winkler, Mathias Gorski & Iris M. Heid

Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK. Andrew R. Wood, Dorota Pasko, Michael N. Weedon, John R. B. Perry & Timothy M. Frayling

Department of Nutrition, Harvard School of Public Health, Boston, 02115, Massachusetts, USA Tsegaselassie Workalemahu, Lu Qi, Paul W. Franks & David J. Hunter

Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, 48104, Michigan, USA Jessica D. Faul & David R. Weir

Department of Epidemiology, University of Michigan, Ann Arbor, 48109, Michigan, USA Jennifer A. Smith & Wei Zhao

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, 48109, Michigan, USA Jin Chen & Cristen J. Willer

Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. Rudolf Fehrmann, Juha Karjalainen, Joanna Smolonska, Morris A. Swertz, Harm-Jan Westra, Pim van der Harst & Lude Franke

Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, 48109, Michigan, USA Ellen M. Schmidt & Cristen J. Willer

HudsonAlpha Institute for Biotechnology, Huntsville, 35806, Alabama, USA Devin Absher & Lindsay L. Waite

Department of Epidemiology, Genetic Epidemiology Unit, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands. Najaf Amin, Ayse Demirkan, Aaron Isaacs, Ben A. Oostra & Cornelia M. van Duijn

Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, 6008, Western Australia, Australia Denise Anderson

Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands. Marian Beekman, Stefan Böhringer, Quinta Helmer, Hae-Won Uh, Lisette Stolk & P. Eline Slagboom

Department of Molecular Epidemiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. Marian Beekman & P. Eline Slagboom

Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK. Jennifer L. Bolton, Ross M. Fraser, Stela McLachlan, Harry Campbell, Jackie F. Price, Igor Rudan & James F. Wilson

Kidney Epidemiology and Cost Center, University of Michigan, Ann Arbor, 48109, Michigan, USA Jennifer L. Bragg-Gresham

Department of Statistics & Biostatistics, Rutgers University, Piscataway, 08854, New Jersey, USA Steven Buyske

Department of Genetics, Rutgers University, Piscataway, 08854, New Jersey, USA Steven Buyske & Tara C. Matise

Department of Human Genetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands. Ayse Demirkan

Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK. Guohong Deng, Weihua Zhang, William R. Scott, Sian-Tsung Tan, Jaspal S. Kooner & John C. Chambers

Department of Gastroenterology and Hepatology, Imperial College London, London W2 1PG, UK. Guohong Deng

Institute of infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing, China Guohong Deng

Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA Georg B. Ehret & Aravinda Chakravarti

Department of Specialties of Internal Medicine, Cardiology, Geneva University Hospital, Geneva 1211, Switzerland. Georg B. Ehret & François Mach

Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark. Bjarke Feenstra, Heather A. Boyd & Frank Geller

Department of Genetics, Washington University School of Medicine, St Louis, 63110, Missouri, USA Mary F. Feitosa, E. Warwick Daw, Mary K. Wojczynski, Qunyuan Zhang, Aldi T. Kraja, D. C. Rao & Ingrid B. Borecki

Division of Cardiovacular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK. Anuj Goel, Martin Farrall & Hugh Watkins

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, 98109, Washington, USA Jian Gong, Jeffrey Haessler, Charles Kooperberg & Ulrike Peters

William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Stavroula Kanoni, Kathleen Stirrups & Panos Deloukas

Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany. Marcus E. Kleber, Graciela Delgado, Tanja B. Grammer & Winfried März

Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany. Marcus E. Kleber & Wolfgang Koenig

National Institute for Health and Welfare, FI-00271 Helsinki, Finland. Kati Kristiansson, Niina Eklund, Leena Kinnunen, Jaana Lindström, Johan G. Eriksson, Pekka Jousilahti, Antti M. Jula, Jaakko Kaprio, Paul Knekt, Satu Männistö, Veikko Salomaa, Jarmo Virtamo, Markus Perola & Jaakko Tuomilehto

Epidemiology Program, University of Hawaii Cancer Center, Honolulu, 96813, Hawaii, USA Unhee Lim, Lynne R. Wilkens & Loic Le Marchand

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, 10029, New York, USA Vaneet Lotay, Janina M. Jeff, Yingchang Lu, Omri Gottesman, Erwin P. Bottinger & Ruth J. F. Loos

Department of Twin Research and Genetic Epidemiology, King’s College London, London SE1 7EH, UK. Massimo Mangino, Cristina Menni, Alireza Moayyeri, John R. B. Perry & Tim D. Spector

Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands. Irene Mateo Leach, Niek Verweij & Pim van der Harst

Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands. Carolina Medina-Gomez, Marjolein J. Peters, Oscar H. Franco, Albert Hofman, M. Carola Zillikens, Fernando Rivadeneira, André G. Uitterlinden & Cornelia M. van Duijn

Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands. Carolina Medina-Gomez, Oscar H. Franco, Albert Hofman, Jacqueline C. Witteman, Fernando Rivadeneira, André G. Uitterlinden & Cornelia M. van Duijn

Department of Internal Medicine, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands. Carolina Medina-Gomez, Marjolein J. Peters, Karol Estrada, Lisette Stolk, M. Carola Zillikens, Fernando Rivadeneira & André G. Uitterlinden

QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. Sarah E. Medland, Scott D. Gordon, Grant W. Montgomery, Dale R. Nyholt & Nicholas G. Martin

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, 20892, Maryland, USA Michael A. Nalls

Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany. Sonali Pechlivanis, Karl-Heinz Jöckel, Susanne Moebus & André Scherag

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK. Inga Prokopenko, Amy Barrett, Amanda J. Bennett, Christopher J. Groves, Nigel W. Rayner, Neil R. Robertson, Fredrik Karpe & Mark I. McCarthy

Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. Inga Prokopenko & Philippe Froguel

Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden. Dmitry Shungin, Frida Renstrom & Paul W. Franks

Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden. Dmitry Shungin & Paul W. Franks

Department of Odontology, Umeå University, Umeå 901 85, Sweden. Dmitry Shungin

University of Eastern Finland, FI-70210 Kuopio, Finland. Alena Stančáková

Department of Medicine, Atherosclerosis Research Unit, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden. Rona J. Strawbridge, Lasse Folkersen, Per Eriksson, Jesper R. Gådin, Ferdinand M. van’t Hooft & Anders Hamsten

Division of Biostatistics, Washington University School of Medicine, St Louis, 63110, Missouri, USA Yun Ju Sung, D. C. Rao & Treva K. Rice

Translational Gerontology Branch, National Institute on Aging, Baltimore, 21225, Maryland, USA Toshiko Tanaka & Luigi Ferrucci

Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany. Alexander Teumer, Georg Homuth & Uwe Völker

Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. Stella Trompet & J. Wouter Jukema

Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. Stella Trompet & Anton J. M. de Craen

Division Heart and Lungs, Experimental Cardiology Laboratory, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. Sander W. van der Laan, Hester M. den Ruijter & Gerard Pasterkamp

Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. Jessica van Setten & Paul I. W. de Bakker

Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands. Jana V. Van Vliet-Ostaptchouk

Core Genotyping Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. Zhaoming Wang & Kevin B. Jacobs

CNRS UMR 8199, F-59019 Lille, France. Loïc Yengo, Elodie Eury, Stéphane Lobbens, Stéphane Cauchi & Philippe Froguel

European Genomic Institute for Diabetes, F-59000 Lille, France. Loïc Yengo, Elodie Eury, Stéphane Lobbens, Stéphane Cauchi & Philippe Froguel

Université de Lille 2, F-59000 Lille, France. Loïc Yengo, Elodie Eury, Stéphane Lobbens, Stéphane Cauchi & Philippe Froguel

Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK. Weihua Zhang, William R. Scott, Marjo-Riitta Jarvelin & John C. Chambers

Center for Medical Sytems Biology, 2300 RC Leiden, The Netherlands. Aaron Isaacs, Ben A. Oostra & Cornelia M. van Duijn

Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany. Eva Albrecht, Harald Grallert, Martina Müller-Nurasyid, Janina S. Ried, Christian Gieger, Konstantin Strauch & Iris M. Heid

School of Health and Social Studies, Dalarna University, SE-791 88 Falun, Sweden. Johan Ärnlöv

PathWest Laboratory Medicine of Western Australia, Nedlands, 6009, Western Australia, Australia Gillian M. Arscott, John Beilby & Jennie Hui

Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK. Antony P. Attwood & Jennifer Jolley

NHS Blood and Transplant, Cambridge CB2 0PT, UK. Antony P. Attwood & Jennifer Jolley

Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50125 Florence, Italy. Stefania Bandinelli

USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines. Isabelita N. Bas & Nanette R. Lee

Department of Genetics, Texas Biomedical Research Institute, San Antonio, 78227, Texas, USA Claire Bellis & John Blangero

Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, 4001, Queensland, Australia Claire Bellis

Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden. Christian Berne

Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany. Roza Blagieva & Sigrun Merger

Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany. Matthias Blüher, Yvonne Böttcher, Peter Kovacs, Anke Tönjes & Michael Stumvoll

Department of Medicine, University of Leipzig, D-04103 Leipzig, Germany. Matthias Blüher, Peter Kovacs, Anke Tönjes & Michael Stumvoll

Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands. Stefan Böhringer, Quinta Helmer & Hae-Won Uh

Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA. Lori L. Bonnycastle, Mario A. Morken, Amy J. Swift, Peter S. Chines & Francis S. Collins

LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. Marcel Bruinenberg & Salome Scholtens

Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway. Ida H. Caspersen & Berit Johansen

Department of Pediatrics, University of California Los Angeles, Torrance, 90502, California, USA Yii-Der Ida Chen

Transgenomics Institute, Los Angeles Biomedical Research Institute, Torrance, 90502, California, USA Yii-Der Ida Chen

Nuffield Department of Population Health, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF, UK. Robert Clarke

Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece. Maria Dimitriou & George Dedoussis

Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK. Alex S. F. Doney, Andrew D. Morris & Colin N. A. Palmer

Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland. Niina Eklund, Jaakko Kaprio, Leif C. Groop & Markus Perola

Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, Massachusetts, USA Karol Estrada & Stephan Ripke

Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, 20892, Maryland, USA Melissa E. Garcia & Tamara B. Harris

Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden. Vilmantas Giedraitis

Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden. Bruna Gigante, Karin Leander & Ulf de Faire

Division of Research, Kaiser Permanente, Oakland, 94612, California, USA Alan S. Go

Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland. Alain Golay

Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK. Alison H. Goodall & Nilesh J. Samani

National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK. Alison H. Goodall & Nilesh J. Samani

Department of Nephrology, University Hospital Regensburg, D-93053 Regensburg, Germany. Mathias Gorski

Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany. Hans-Jörgen Grabe

German Center for Neurodegenerative Diseases (DZNE), Rostock, Greifswald, D-17475 Greifswald, Germany. Hans-Jörgen Grabe

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany. Harald Grallert, Thomas Illig & Annette Peters

German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. Harald Grallert & Barbara Thorand

Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany. Jürgen Gräßler, Peter E. H. Schwarz & Stefan R. Bornstein

Institut inter Régional pour la Santé, Synergies, F-37520 La Riche, France. Gaëlle Gusto

Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden. Goran Hallmans

Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands. Catharina A. Hartman & Albertine J. Oldehinkel

Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland. Maija Hassinen, Timo A. Lakka & Rainer Rauramaa

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK. Caroline Hayward & Alan F. Wright

National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, 01702, Massachusetts, USA Nancy L. Heard-Costa, Joanne M. Murabito, L. Adrienne Cupples & Caroline S. Fox

Department of Neurology, Boston University School of Medicine, Boston, 02118, Massachusetts, USA Nancy L. Heard-Costa

Faculty of Psychology and Education, VU University Amsterdam, 1081BT Amsterdam, The Netherlands. Quinta Helmer

Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany. Christian Hengstenberg, Martina Müller-Nurasyid, Annette Peters & Heribert Schunkert

Deutsches Herzzentrum München, Technische Universität München, D-80636 Munich, Germany. Christian Hengstenberg & Heribert Schunkert

Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway. Oddgeir Holmen & Kristian Hveem

Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands. Jouke-Jan Hottenga & Gonneke Willemsen

Department of Pulmonary Physiology and Sleep Medicine, Nedlands, 6009, Western Australia, Australia Alan L. James

School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia. Alan L. James

Department of Immunology, Uppsala University, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden. Åsa Johansson & Ulf Gyllensten

Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland. Markku Koskenvuo & Jaakko Kaprio

Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany. Wolfgang Kratzer & Thomas Seufferlein

Finnish Institute of Occupational Health, FI-90100 Oulu, Finland. Jaana Laitinen

Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria. Claudia Lamina

Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany. Peter Lichtner

Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden. Lars Lind & Johan Sundström

Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada. Ken Sin Lo & John D. Rioux

Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany. Roberto Lorbeer

The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, 10029, New York, USA Yingchang Lu & Ruth J. F. Loos

School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK. Wendy L. McArdle & Josine L. Min

Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia. Evelin Mihailov & Andres Metspalu

Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK. Alireza Moayyeri

The Center for Observational Research, Amgen, Inc., Thousand Oaks, 91320, California, USA Keri L. Monda

Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy. Antonella Mulas & Serena Sanna

Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany. Gabriele Müller

Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-Universität, D-81377 Munich, Germany. Martina Müller-Nurasyid

Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, D-81377 Munich, Germany. Martina Müller-Nurasyid & Konstantin Strauch

Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, 6009, Western Australia, Australia Arthur W. Musk

Laboratory of Genetics, National Institute on Aging, Baltimore, 21224, Maryland, USA Ramaiah Nagaraja & David Schlessinger

Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany. Markus M. Nöthen

Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany. Markus M. Nöthen

Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. Ilja M. Nolte

Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands. Stefan Pilz

Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, 8036 Graz, Austria. Stefan Pilz

Institute of Physiology, University Medicine Greifswald, D-17495 Karlsburg, Germany. Rainer Rettig

Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, 02142, Massachusetts, USA Stephan Ripke & Steven A. McCarroll

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, 02215, Massachusetts, USA Lynda M. Rose, Daniel I. Chasman & Paul M. Ridker

Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria. Hubert Scharnagl & Winfried März

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90089, California, USA Fredrick R. Schumacher & Christopher A. Haiman

National Cancer Institute, Bethesda, 20892, Maryland, USA Jianxin Shi

Icelandic Heart Association, Kopavogur 201, Iceland. Albert Vernon Smith & Vilmundur Gudnason

University of Iceland, Reykjavik 101, Iceland. Albert Vernon Smith & Vilmundur Gudnason

Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. Joanna Smolonska, Judith M. Vonk, Ronald P. Stolk & Harold Snieder

Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen’s Green, Dublin 2, Ireland. Alice V. Stanton

deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland. Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Unnur Thorsteinsdottir & Kari Stefansson

Department of Medical Sciences, Molecular Medicine, Uppsala University, Uppsala 75144, Sweden. Ann-Christine Syvänen

National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK. Sian-Tsung Tan, Miriam F. Moffatt & Jaspal S. Kooner

Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, 61053, Illinois, USA Bamidele O. Tayo & Richard S. Cooper

Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany. Barbara Thorand & Annette Peters

Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK. Jonathan P. Tyrer

Department of Internal Medicine and Clinical Nutrition, Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden. Liesbeth Vandenput & Claes Ohlsson

Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands. Frank C. Verhulst

Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. Sita H. Vermeulen & Lambertus A. Kiemeney

Department of Genetics, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. Sita H. Vermeulen

Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Helen R. Warren, Mark J. Caulfield & Patricia B. Munroe

Genetics, GlaxoSmithKline, King of Prussia, 19406, Pennsylvania, USA Dawn Waterworth

German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany. Christina Willenborg & Jeanette Erdmann

Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, D-23562 Lübeck, Germany. Christina Willenborg & Jeanette Erdmann

Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway. Tom Wilsgaard & Inger Njølstad

MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK. Andrew Wong, Ken K. Ong & Diana Kuh

Diabetes Complications Research Centre, Conway Institute, School of Medicine and Medical Sciences, University College Dublin, Dublin 4, Ireland. Eoin P. Brennan

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea Murim Choi

Departments of Human Genetics, Lady Davis Institute, Epidemiology and Biostatistics, McGill University, Montréal, Québec H3T1E2, Canada. Zari Dastani

Department of Molecular Medicine and Surgery, Cardiothoracic Surgery Unit, Karolinska Institutet, Stockholm 17176, Sweden. Anders Franco-Cereceda

Department of Medicine, Columbia University College of Physicians and Surgeons, 10032, New York, USA Ali G. Gharavi & Krzysztof Kiryluk

Biosciences Research Division, Department of Primary Industries, Victoria 3083, Australia. Michael E. Goddard

Department of Food and Agricultural Systems, University of Melbourne, Victoria 3010, Australia. Michael E. Goddard

Department of Epidemiology, Harvard School of Public Health, Boston, 02115, Massachusetts, USA Jinyan Huang, Liming Liang, Baoshan Ma & David J. Hunter

State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, Shanghai, China Jinyan Huang

NIHR Oxford Biomedical Research Centre, OUH Trust, Oxford OX3 7LE, UK. Fredrik Karpe

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA Sekar Kathiresan

Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Michiaki Kubo

Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Chungbuk 363–951, Republic of Korea. Jong-Young Lee

Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, 2115, Massachusetts, USA Liming Liang

Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven, 06520, Connecticut, USA Richard P. Lifton

College of Information Science and Technology, Dalian Maritime University, Dalian, 116026, Liaoning, China Baoshan Ma

Nephrology Research, Centre for Public Health, Queen’s University of Belfast, Belfast, County Down BT9 7AB, UK. Amy J. McKnight

Section of General Internal Medicine, Boston University School of Medicine, Boston, 02118, Massachusetts, USA Joanne M. Murabito

Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK. George Nicholson

MRC Harwell, Harwell Science and Innovation Campus, Harwell OX11 0QG, UK. George Nicholson

Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, 4059, Queensland, Australia Dale R. Nyholt

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Yukinori Okada & Atsushi Takahashi

Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan. Yukinori Okada & Toshihiro Tanaka

Genome Institute of Singapore, Agency for Science, Technology and Research, 138672 Singapore. Rajkumar Dorajoo

Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki FI-00076, Finland. Niina Sandholm

Department of Medicine, Division of Nephrology, Helsinki University Central Hospital, FI-00290 Helsinki, Finland. Niina Sandholm

Folkhälsan Institute of Genetics, Folkhälsan Research Center, FI-00290 Helsinki, Finland. Niina Sandholm

Laboratory for Cardiovascular Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan. Toshihiro Tanaka

Division of Disease Diversity, Bioresource Research Center, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan. Toshihiro Tanaka

Division of Epidemiology, Department of Medicine; Vanderbilt Epidemiology Center Wei Zheng

Vanderbilt Epidemiology Center, Nashville, 37075, Tennessee, USA Wei Zheng

Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford OX3 7BN, UK. Krina T. Zondervan

Department of Psychiatry, Washington University School of Medicine, St Louis, 63110, Missouri, USA Andrew C. Heath, Pamela A. F. Madden, D. C. Rao & Treva K. Rice

Department of Epidemiology and Public Health, EA3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France Dominique Arveiler

Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands. Stephan J. L. Bakker & Ron T. Gansevoort

Pathology and Laboratory Medicine, The University of Western Australia, Perth, 6009, Western Australia, Australia John Beilby & Jennie Hui

Cedars-Sinai Diabetes and Obesity Research Institute, Los Angeles, 90048, California, USA Richard N. Bergman

Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland. Pascal Bovet & Murielle Bochud

Ministry of Health, Victoria, Republic of Seychelles Pascal Bovet & Murielle Bochud

University of Milano, Bicocca, 20126, Italy. Giancarlo Cesana

Harvard Medical School, Boston, 02115, Massachusetts, USA Daniel I. Chasman & Paul M. Ridker

Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, 37203, Tennessee, USA Dana C. Crawford

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, 37232, Tennessee, USA Dana C. Crawford

Department of Biostatistics, Boston University School of Public Health, Boston, 02118, Massachusetts, USA L. Adrienne Cupples

Department of Health Sciences, University of Milano, I 20142, Italy. Daniele Cusi

Fondazione Filarete, Milano I 20139, Italy. Daniele Cusi

Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK. John Danesh & Danish Saleheen

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. Hester M. den Ruijter

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. Anna F. Dominiczak

Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45147 Essen, Germany. Raimund Erbel

Department of General Practice and Primary Health Care, University of Helsinki, FI-00290 Helsinki, Finland. Johan G. Eriksson

Unit of General Practice, Helsinki University Central Hospital, Helsinki 00290, Finland. Johan G. Eriksson

Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany. Stephan B. Felix

DZHK (Deutsches Zentrum für Herz-Kreislaufforschung – German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany. Stephan B. Felix, Uwe Völker & Henri Wallaschofski

Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy. Ele Ferrannini

National Research Council Institute of Clinical Physiology, University of Pisa, 56124 Pisa, Italy. Ele Ferrannini

Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, 31400 Toulouse, France. Jean Ferrières

Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK. Ian Ford

UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica. Terrence Forrester & Colin A. McKenzie

NorthShore University HealthSystem, Evanston, IL 60201, University of Chicago, Chicago, Illinois, USA Pablo V. Gejman

Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS2 9LU, UK. Alistair S. Hall

Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK. Andrew T. Hattersley

Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany). Andrew A. Hicks & Peter P. Pramstaller

Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, 20892, Maryland, USA Lucia A. Hindorff

Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK. Aroon D. Hingorani & Folkert W. Asselbergs

Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands. G. Kees Hovingh & John J. P. Kastelein

Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK. Steve E. Humphries

Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, 84108, Utah, USA Steven C. Hunt

Sansom Institute for Health Research, University of South Australia, Adelaide, 5000, South Australia, Australia Elina Hyppönen

School of Population Health, University of South Australia, Adelaide, 5000, South Australia, Australia Elina Hyppönen

South Australian Health and Medical Research Institute, Adelaide, 5000, South Australia, Australia Elina Hyppönen

Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK. Elina Hyppönen & Chris Power

Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625 Hannover, Germany. Thomas Illig

National Institute for Health and Welfare, FI-90101 Oulu, Finland. Marjo-Riitta Jarvelin

MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK. Marjo-Riitta Jarvelin

Unit of Primary Care, Oulu University Hospital, FI-90220 Oulu, Finland. Marjo-Riitta Jarvelin

Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland. Marjo-Riitta Jarvelin, Marjo-Riitta Jarvelin & Sirkka M. Keinanen-Kiukaanniemi

Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands (ICIN), 3501 DG Utrecht, The Netherlands. J. Wouter Jukema, Folkert W. Asselbergs & Pim van der Harst

Interuniversity Cardiology Institute of the Netherlands (ICIN), 3501 DG Utrecht, The Netherlands. J. Wouter Jukema

Unit of Primary Health Care/General Practice, Oulu University Hospital, FI-90220 Oulu, Finland. Sirkka M. Keinanen-Kiukaanniemi

Department of Urology, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands. Lambertus A. Kiemeney

Imperial College Healthcare NHS Trust, London W12 0HS, UK. Jaspal S. Kooner & John C. Chambers

Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK. Meena Kumari, Claudia Langenberg & Mika Kivimaki

Department of Biological and Social Epidemiology, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK. Meena Kumari

Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland. Johanna Kuusisto & Markku Laakso

Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, FI-70211 Kuopio, Finland. Timo A. Lakka

Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland. Timo A. Lakka & Rainer Rauramaa

Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland. Terho Lehtimäki

Steno Diabetes Center A/S, Gentofte DK-2820, Denmark. Valeriya Lyssenko

Lund University Diabetes Centre and Department of Clinical Science, Diabetes & Endocrinology Unit, Lund University, Malmö 221 00, Sweden. Valeriya Lyssenko & Leif C. Groop

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada. André Marette

Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada. André Marette, Marie-Claude Vohl & Louis Pérusse

Department of Biostatistics, University of Washington, Seattle, 98195, Washington, USA Barbara McKnight

Department of Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. Frans L. Moll

Department of Biostatistics, University of Liverpool, Liverpool L69 3GA, UK. Andrew P. Morris

Department of Pediatrics, University of Iowa, Iowa City, 52242, Iowa, USA Jeffrey C. Murray

Illumina, Inc, Little Chesterford, Cambridge CB10 1XL, UK. John F. Peden

Department of Pulmonary Medicine and Tuberculosis, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Dirkje S. Postma

Department of Neurology, General Central Hospital, Bolzano 39100, Italy. Peter P. Pramstaller

Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland. Olli T. Raitakari

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, FI-20521 Turku, Finland. Olli T. Raitakari

Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, 70808, Louisiana, USA Tuomo Rankinen, Mark A. Sarzynski & Claude Bouchard

Université de Montréal, Montreal, Quebec H1T 1C8, Canada. John D. Rioux

Center for Systems Genomics, The Pennsylvania State University, University Park, 16802, Pennsylvania, USA Marylyn D. Ritchie

Croatian Centre for Global Health, Faculty of Medicine, University of Split, 21000 Split, Croatia. Igor Rudan

South Carelia Central Hospital, 53130 Lappeenranta, Finland. Jouko Saramies

Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), 01307 Dresden, Germany. Peter E. H. Schwarz

International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK. Peter Sever

Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA Alan R. Shuldiner & Jeffrey R. O’Connell

Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA Alan R. Shuldiner & Jeffrey R. O’Connell

Geriatric Research and Education Clinical Center, Vetrans Administration Medical Center, Baltimore, 21201, Maryland, USA Alan R. Shuldiner

Department of Medicine, Helsinki University Central Hospital Heart and Lung Center, Helsinki University Central Hospital, FI-00290 Helsinki, Finland. Juha Sinisalo

Sorbonne Universités, UPMC Univ Paris 06, UMR S 1166, F-75013 Paris, France. David-Alexandre Trégouët

INSERM, UMR S 1166, Team Genomics and Physiopathology of Cardiovascular Diseases, F-75013 Paris, France. David-Alexandre Trégouët

Institute for Cardiometabolism And Nutrition (ICAN), F-75013 Paris, France. David-Alexandre Trégouët

Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada. Angelo Tremblay & Louis Pérusse

Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, Italy. Elena Tremoli

Department of Food Science and Nutrition, Laval University, Quebec QC G1V 0A6, Canada. Marie-Claude Vohl

Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne 1011, Switzerland. Gérard Waeber

Department of Nutrition, University of North Carolina, Chapel Hill, 27599, North Carolina, USA Linda S. Adair

Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France. Philippe Amouyel

INSERM, U744 Philippe Amouyel

Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. Folkert W. Asselbergs

Department of Medicine, Stanford University School of Medicine, Palo Alto, 94304, California, USA Themistocles L. Assimes, Mads Melbye & Thomas Quertermous

Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore. Bernhard O. Boehm

Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany. Bernhard O. Boehm

Health Science Center at Houston, University of Texas, Houston, 77030, Texas, USA Eric Boerwinkle

Department of Medicine, Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA Paul I. W. de Bakker

Department of Epidemiology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. Paul I. W. de Bakker

School of Population Health, The University of Western Australia, Nedlands, 6009, Western Australia, Australia Jennie Hui

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Belfer 1306, New York 10461, USA. Robert C. Kaplan

Division of Public Health Sciences, Center for Human Genetics, Wake Forest School of Medicine, Winston-Salem, 27157, North Carolina, USA Yongmei Liu

Synlab Academy, Synlab Services GmbH, 68163 Mannheim, Germany. Winfried März

Department of Clinical Medicine, Copenhagen University, 2200 Copenhagen, Denmark. Mads Melbye

Department of Clinical Genetics, Erasmus MC University Medical Center, 3000 CA Rotterdam, The Netherlands. Ben A. Oostra

Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland. Timo E. Saaristo

Pirkanmaa Hospital District, FI-33521 Tampere, Finland. Timo E. Saaristo

Center for Non-Communicable Diseases, Karatchi, Pakistan Danish Saleheen

Department of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA Danish Saleheen

Division of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK. Naveed Sattar

Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, 10580, New York, USA Eric E. Schadt

Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland. Unnur Thorsteinsdottir & Kari Stefansson

Institute for Health Research, University Hospital of La Paz (IdiPaz), 28046 Madrid, Spain. Jaakko Tuomilehto

Diabetes Research Group, King Abdulaziz University, 21589 Jeddah, Saudi Arabia. Jaakko Tuomilehto

Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria. Jaakko Tuomilehto

Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland Matti Uusitupa

Research Unit, Kuopio University Hospital, FI-70210 Kuopio, Finland. Matti Uusitupa

Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK. Mark Walker

Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany. Henri Wallaschofski

Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany. H-Erich Wichmann

Klinikum Grosshadern, D-81377 Munich, Germany. H-Erich Wichmann

Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany, D-85764 Neuherberg, Germany. H-Erich Wichmann

Department of Pulmonology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands. Pieter Zanen

Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, 21589 Jeddah, Saudi Arabia. Panos Deloukas

Division of Population Health Sciences & Education, St George’s, University of London, London SW17 0RE, UK. David P. Strachan

Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Trust, Oxford OX3 7LJ, UK. Mark I. McCarthy

Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, 07743 Jena, Germany. André Scherag

Department of Human Genetics, University of Michigan, Ann Arbor, 48109, Michigan, USA Cristen J. Willer

Service of Medical Genetics, CHUV University Hospital, 1011 Lausanne, Switzerland. Jacques S. Beckmann

University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 OQQ, UK. Inês Barroso

NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge CB2 OQQ, UK. Inês Barroso

Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, 27599, North Carolina, USA Kari E. North