Less than 48 hours before the Giants open their season against the Cowboys, Odell Beckham Jr.’s status remains uncertain.

The star receiver officially was listed as questionable on the Giants’ injury report Friday, meaning Beckham is being given a 50 percent chance to play against the Cowboys at AT&T Stadium.

Beckham, who suffered a sprained left ankle on Aug. 21 in a preseason game against the Browns, hasn’t practiced since the injury, though coach Ben McAdoo said the receiver has a “chance” to participate in a light session with the team Saturday.

Beckham told SNY’s Taylor Rooks on Friday that he was “feeling a lot better,” but had a “long evening of rehab” ahead.

“Then we’ll see,” Beckham said.

Last season — the first year the “probable” designation was eliminated from injury reports — 70 percent of Giants players listed as questionable ended up playing that week, according to the San Diego Union Tribune. Cowboys receiver Dez Bryant said he believes the tag will be misleading again in Bryant’s case.

Bryant, a close friend of Beckham’s, said the two receivers have spoken this week, but only discussed “buddy stuff.”

“I’m pretty sure he’s going to play,” Bryant said after Friday’s practice. “He’s the heart and soul of that squad.”

Beckham has increased his work at the Giants’ facility this week, but he still hasn’t been seen sprinting or cutting.

McAdoo has said Beckham will play if he is medically cleared, and it isn’t necessary for the 24-year-old to practice in order to take the field against the Cowboys.

“He’s doing everything he can to get himself well,” McAdoo said. “We will see how he responds.”

If Beckham plays at less than full strength, the three-time Pro Bowler still likely can do more than most receivers in the league. If Beckham is close to fully healthy, he instantly transforms the Giants offense into one of the league’s most dangerous attacks.

Should Beckham sit out, the team’s offensive ceiling could crash to the ground.

Since missing the first four games of his rookie season with a hamstring injury, Beckham has missed just one other game, after being suspended for his infamous altercation with Josh Norman in December 2015.

Without Beckham the following week at Minnesota, the Giants were embarrassed, 49-17, with Eli Manning tying a season-high with three interceptions, while completing 15-of-29 passes and finishing with a 50.7 passer rating. In 15 games with Beckham that season, the Giants averaged nearly 27 points per game, in which Manning was intercepted a total of 11 times, and the team tied for the most passing touchdowns in the league.

But unlike during that lopsided loss to the Vikings, Manning now has many more weapons besides Beckham.

“I don’t think the preparation is different,” Manning said. “I think guys know what their assignments are. Just go about our business and still run the same plays and guys have to know how to execute and we have the guys that can do that.”

There is Brandon Marshall, a six-time Pro Bowler, who would be a No. 1 receiver on many teams. There is Sterling Shepard, last year’s second-round pick and the team’s second-leading receiver, whose eight touchdowns only trailed Beckham by two. There is first-round pick Evan Engram, the tight end who could be confused for a wide receiver.

Even if the Giants need Beckham on the field to play their best, they have to believe they don’t.

“We’d throw someone else in there and move on,” Shepard said Friday. “You’ve just got to make plays. We just need to take care of the ball, and this can be an explosive offense, one that can hopefully win us a championship.”

— Additional reporting by Zach Braziller