Nestled in the heart of Rome, this 16th century Italian Renaissance mega-mansion — valued at nearly $44 million (€38,000,000) — is about to become the first piece of real estate to accept cryptocurrency bids at auction.

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The nearly 18,000-square-foot residence, known as the "Palazzetto," is located on the Piazza Di Campitelli, just a short distance from the historic Colosseum. The residence now houses apartments, and VIPs who have stayed there include the CEO of Louis Vuitton, Michael Burke; the former CEO of Ferrari, Luca Cordero di Montezemolo; as well as actor Mel Gibson. Take a look inside. The four-level residence was built by Renaissance architects Giacomo Della Porta (1532-1602) and Girolamo Rainaldi (1570-1655). Della Porta is most recognized for his work on the iconic Dome of St. Peter's Basilica — having collaborated with the great Michelangelo.

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"Not only is the Palazzetto a beautiful property, but it's also a work of art," says Alexander Ali, founder of Society Group, the U.S.-based real estate marketing firm that's representing the property. "Everywhere you turn is a piece of history."

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Constructed between 1580 and 1616, the Renaissance manor consists of three luxury suites that include 11 bedrooms and 15 bathrooms.

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It is filled with mural paintings and sculptures. "The Little Chapel" is just one of the home's many frescoes — or watercolor paintings — that dates back to the 18th century.

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Outside, there's a 2,000-square-foot secret garden dotted with citrus trees.

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"The architect carved out [the garden] as a private oasis just for the owners," Ali tells CNBC. "It really is unheard of to have this much green space in the heart of Rome." A spiral staircase leads to the rooftop with picture perfect views of the ancient city.

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The mansion's seller is also offering suggested renderings for a modern gym, spa and movie theater.

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