The Packers were bested by the Eagles 34-27 at home in the fourth Thursday night showdown of the 2019 NFL season. This is Green Bay’s first loss of the season, and Philadelphia moves to 2-2 after a must-win game that was fraught with penalties and injuries to key players. Davante Adams, Kevin King, Bryan Bulaga, Tony Brown, Sidney Jones and Will Redmond were all injured during the game. Avonte Maddox and Jamaal Williams all suffered frightening head injuries and had to be stretchered off.

Here are 6 things you need to know for fantasy football:

1. Davante Adams has monster night, exits game with turf toe injury

Adams had 180 yards on 10 receptions, 158 of which came in the first half. He did not score a touchdown, however, and exited the game in the fourth quarter after making a catch on the sideline. Adams immediately grabbed his toe and spent some time in the injury tent. It was later reported by Rob Demovsky of ESPN that Adams sustained a turf toe injury that he described as extremely painful. He is set to undergo additional tests on Friday.

This would be a significant loss for the Packers and Aaron Rodgers, as Adams was the second-most targeted receiver in 2018 behind Julio Jones. Geronimo Allison and Marquez Valdes-Scantling would likely share targets if Adams’ injury is serious.

2. Eagles running backs soar

Faced with the challenge of going up against a couple of the league’s top cornerbacks, the Eagles leaned on the run game heavily on Thursday and attacked Green Bay’s defensive line. Jordan Howard had a three-touchdown night and led Philadelphia in rushing. He had 15 carries for 87 yards and two rushing touchdowns, in addition to three catches for 38 yards and a receiving touchdown. At only 54% owned, he will be a popular waiver add next week in shallower leagues.

Miles Sanders flashed big-play ability with a punt return for 67 yards in the second quarter which set up the Eagles for their first scoring drive after falling down 10-0. He also had 11 rushing attempts for 72 yards. The rookie’s continued utilization in this offense is encouraging in light of Sanders’ two fumbles in Week 3 against the Lions. His ball security issues stem back to his college days at Penn State where he backed up Giants running back Saquon Barkley.

3. Jamaal Williams concussed in scary collision

Jamaal Williams took a nasty helmet-to-helmet hit by defensive end Derek Barnett early in the first quarter. He was knocked out and taken off the field on a stretcher to be evaluated by medical staff. The team reported that while he was ruled out for the game, he did have feeling and movement in all extremities.

The Packers are thin at the running back position. The only other active player was fullback Danny Vitale; rookie Dexter Williams did not dress on Thursday. If Jamaal Williams misses time, Aaron Jones, who is already the feature back for this squad, would see an increased workload, and Dexter Williams would most likely back up Jones.

4. Aaron Jones stymied by Eagles run defense

Jones scored a touchdown, but had an overall quiet night with 13 rushes for 21 yards. He had slightly more luck in the passing game, with six catches for 37 yards. The Packers were unable to establish any momentum in the run game, but Jones’ 1.6 yards per attempt should not make owners panic. The Eagles will be a tough unit to match up against this season, and with Williams now hurt, the volume will be there for Jones to salvage any fantasy day.

5. Aaron Rodgers suffers without protection

Rodgers passed for 422 yards on a whopping 53 attempts for 34 completions, two touchdowns and one interception. He had a signature two-minute drill to close out the first half, but missed a number of key throws in the red zone including a pass that was picked off to end the game.

Rodgers’ struggles were enhanced by the loss of right tackle Bulaga, who exited the game early with a shoulder injury. Alex Light subbed in for Bulaga but later, left tackle David Bakhtiari was seen on the sidelines having his neck worked on. Bakhtiari reentered the game, but the health of this offensive line has a huge impact on Rodgers’ success.

6. Tight ends play a big role

Dallas Goedert did a Lambeau Leap and came away with his best game of the year. He was targeted three times and caught two passes for 16 yards and a touchdown. Goedert plays a big role in blocking and less so as a pass catcher. At 10% owned, he could be added in deep leagues but is not a week-to-week start. Zach Ertz reeled in seven of eight targets for 65 yards. Ertz has yet to score a touchdown this season but retains his TE1 status after another solid outing Thursday night. Jimmy Graham caught six of his nine targets for 61 yards and a touchdown.