A woman has been arrested and charged after allegedly mowing down a love rival in Melbourne's south-east.

The woman's two-timing boyfriend, a 54-year-old man from Clayton, also had to run for his life.

On Wednesday afternoon he told Seven News both of his girlfriends are "good women" and he had "played them both".

View photos A woman allegedly ran down a love rival in Melbourne on Tuesday night. Source: 7 News More

It is alleged the 40-year-old Doncaster woman was driving behind her boyfriend and his other partner on Bourke Road when she rammed into the back of the victim's Mazda.

The female passenger, 35, jumped out of the car to escape but was allegedly mowed down by the woman as she stood on the footpath.

The car then allegedly sped towards the man who jumped out of the way.

The 35-year-old victim suffered a broken leg and was taken to hospital.

View photos Police at the scene after the alleged incident. Source: 7 News More

The woman has been charged with intentionally causing serious injury, conduct endangering life, stalking and other assault-related matters.

She faced an out-of-sessions hearing on Wednesday evening and was remanded to appear at Melbourne Magistrates Court on Thursday.