Ms. Greene, a widely respected technologist and entrepreneur, said that after leaving Google Cloud, she planned to help female founders of companies by investing in and mentoring them.

Ms. Greene joined Google in 2015 when it acquired Bebop, a start-up she had founded, for $380 million.

She is best known as a co-founder and former chief executive of VMware, whose software for juggling many programs across many computers is widely used in corporate data centers. That kind of “virtual machine” software is one of the technologies that make computing clouds efficient and relatively inexpensive.

Google said this year that its cloud business was generating more than $1 billion in revenue per quarter — which is dwarfed by the tens of billions of dollars that Google generates quarterly from selling online advertising.

“When this journey started, some people would say that Google had great technology but they weren’t sure that customers would rely on Google as their enterprise partner,” Ms. Greene wrote in the blog post. Now, no one is “questioning our seriousness or our abilities.”