The popular Brisbane Markets at Rocklea is set for one of its biggest shake-ups in more than 50 years with a night market including food trucks, market stalls and live entertainment proposed at the site.

Brisbane Markets submitted a development application to Brisbane City Council on Tuesday proposing to run markets on Friday and Saturday nights in a 9180 square metre area in their central trading area.

Brisbane Markets at Rocklea hosts Saturday fresh markets and Sunday trash and treasure markets.

Brisbane Markets has been operating on the 153,058 square metre site at Sherwood Road, Rocklea, since 1964 and currently has 28 warehouses and a five selling floors.

Brisbane Markets Limited CEO Andrew Young told Fairfax Media they was always looking to innovate.