Political analyst Bill Schneider said Wednesday it was politically risky for Sen. Susan Collins Susan Margaret CollinsSenate GOP aims to confirm Trump court pick by Oct. 29: report The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Senate GOP sees early Supreme Court vote as political booster shot MORE (R-Me.) to vote to confirm Supreme Court nominee Brett Kavanaugh given Maine's political environment.

"I think she's got to be worried about antagonizing not just Democrats, but women voters. She's a Republican in a very blue state, and it's very risky for her to vote for Kavanaugh," Schneider told Hill.TV's Joe Concha on "What America's Thinking."

Schneider's comments come after a survey conducted by the left-leaning Public Policy Polling found that 49 percent of voters said they would be less likely to support Collins if she votes to confirm Kavanaugh.

Collins is a critical swing vote in Kavanaugh's confirmation process, along with Sens. Jeff Flake Jeffrey (Jeff) Lane FlakeJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Republican former Michigan governor says he's voting for Biden Maybe they just don't like cowboys: The president is successful, some just don't like his style MORE (R-Ariz.) and Lisa Murkowski Lisa Ann MurkowskiSenate GOP aims to confirm Trump court pick by Oct. 29: report Senate GOP sees early Supreme Court vote as political booster shot Pence defends Trump's 'obligation' to nominate new Supreme Court justice MORE (R-Alaska).

Republicans hold a 51-49 majority, meaning they cannot afford to lose more than one GOP senator without needing help from Democrats to confirm Kavanaugh.

Kavanaugh is facing multiple sexual misconduct allegations, which has upended his nomination process.

Collins on Wednesday blasted President Trump for mocking Kavanaugh's first accuser, Christine Blasey Ford, at a campaign rally on Tuesday.

“The president’s comments were just plain wrong,” Collins told reporters.

Flake also slammed Trump's comments on Wednesday, calling them “kind of appalling.”

— Julia Manchester