We regret to inform you that Jay-Z has been canceled. No, it’s not his future ­album, or his next concert, that has been canceled — but Jay-Z, the human being. He has been axed, nixed, non-personed.

On Wednesday, NFL Commissioner Roger Goodell and Jay-Z announced a partnership between the league and the legendary rapper’s entertainment company, Roc Nation. The partnership would be part entertainment and part activism and involve the NFL’s “Inspire Change” campaign, which will promote criminal justice reform and better police-community relations.

The online backlash came ­almost instantaneously. The ­anger at Jay-Z involved his support for Colin Kaepernick, the ex-49ers quarterback who kneeled during the national anthem in protest against police brutality and hasn’t been signed to an NFL team in years. Kaepernick and his supporters believe it’s because of his activism, not his football skills, that he has been kept out of the NFL.

Jay-Z, once a Kaepernick ­defender, told the Wall Street Journal that there are “two parts of protesting. You go outside and you protest, and then the company or the individual says, ‘I hear you. What do we do next?’ I think we have moved past kneeling. I think it’s time for action.”

The online wokesters found this unacceptable. Twitter exploded with people calling Jay-Z a “sellout.” Jemele Hill wrote a long piece for The Atlantic titled “Jay-Z Helped the NFL Banish Colin Kaepernick,” censuring the rapper as an “accomplice in the league’s hypocrisy.” David Zirin of The Nation, sounding vaguely like a Viet Cong propagandist, ­denounced the NFL-Jay-Z alliance as “a ruling-class compact.”

Can you still listen to Jay-Z’s music? It would probably be safer not to. After all, cancellation by association has happened before and probably will again. The New York Review of Books expelled its editor, Ian Buruma, for publishing an (admittedly lousy) essay by one of the canceled, Jian Ghomeshi, who had taken to the pages of the august literary journal to tell his side of a #MeToo story. And Norm Macdonald lost a “Tonight Show” appearance ­after defending the non-personed Roseanne and Louis CK.

Also canceled last week was Sarah Silverman. The acerbic lefty comedian revealed on a podcast that she had been fired from a movie after a photo surfaced of her in blackface. She was in blackface for a skit on her show “The Sarah Silverman Program,” and she says she was making a point about racism, not being racist herself.

On the podcast, she railed against cancel culture: “If you’re not on board, if you say the wrong thing, if you had a tweet once, everyone is, like, throwing the first stone. It’s so odd. It’s a perversion. It’s really, ‘Look how righteous I am, and now I’m going to press refresh all day long to see how many likes I get in my righteousness.’ ”

Silverman is right, of course, though she has had a good time joining the righteous mob in the past, when the target was anyone on the right.

That’s what makes this latest round of cancellations so interesting. Cancel culture only really works on liberals, by liberals.

The same week as the Jay-Z and Sarah Silverman cancellations, the online mobs descended on conservative commentator Ben Shapiro for his comments on the working poor. “If you had to work more than one job to have a roof over your head or food on the table,” he had said, “you probably shouldn’t have taken the job that’s not paying you enough. That’d be a you problem.”

His critics took Shapiro’s words out of context, but that’s largely irrelevant. The mob raged, tweets were posted, ­Shapiro didn’t apologize and ­everyone moved on.

The left has a circular firing squad going, and the right is largely outside of it. The problem becomes when the outrage fetishists take the screeching into the real world and try to get people fired from their jobs, as happened to Silverman.

If Shapiro answered to a liberal boss, he might have faced similar consequences. Containing the crazies to the internet, and not letting them get their scalps when they take their canceling movement offline, would go a long way toward minimizing their damage.

Jay-Z’s at risk, too: Recall that Nike canceled an entire line of shoes over Kaepernick’s inane PC complaints. In defending the deal, the rapper said: “You can’t just throw someone out if they make a mistake. This is the real world. You can’t say, ‘Oh, you made a mistake, you’re canceled. I’m never speaking to you again.’ That doesn’t accomplish anything.”

He’d better hope people will be making that argument on his ­behalf, too.

Twitter: @Karol