Virology: Virus-induced cytopathic effects

Virus infections have a physical signature (Refractive Index) which can be detected with Nanolive live cell imaging.

In this footage, obtained using Nanolive’s 3D Cell Explorer-fluo we observe the progression of GFP-labelled adenovirus in human bone osteosarcoma epithelial (U2OS) cells. Refractive images were taken every 15 s for 25 mins, and fluorescence images were taken every 5 mins using the FITC channel.

Read our interview to Prof. Clodagh O’Shea from the Salk Institute for Biological Studies (La Jolla, CA, USA) here.

Learn more in our virology section.

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