Marijuana legalization advocates are excited about the departure of Michele Leonhart, the head of the Drug Enforcement Administration, whom they long considered an obstruction in their goal of reforming the nation’s drug laws.

“We are happy to see her go,” says Dan Riffle, the director of federal policies at the Marijuana Policy Project. “She’s a career drug warrior at a time when we’ve decided the ‘War on Drugs’ is an abject failure.”

Leonhart has been at the DEA for 35 years and served as the top dog since 2007. Though the recent scandal involving agents soliciting sex from prostitutes is what will likely most clearly tarnish her reputation, her position on drug policy has led marijuana reform activists to call for her resignation, says says Neill Franklin of Law Enforcement Against Prohibition. Franklin, a veteran of the Maryland state police, calls her position on marijuana reform “archaic.”

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Leonhart has been a major hurdle in the effort to reconsider marijuana as a Schedule 1 substance, which could pave the way for more research into the health benefits of the drug. In 2011, the agency again rejected a petition to reschedule marijuana. According to the Drug Policy Alliance, the agency spent about $100 million in 2012 alone on enforcement regarding medical marijuana laws.

“Leonhart opposed medical marijuana, she opposed sentencing reform, she opposed pretty much everything that Obama was doing and for that matter everything Congress was doing,” says Bill Piper, the director of National Affairs at the Drug Policy Alliance.

The Drug Policy Alliance is one of several drug and marijuana policy organizations that have previously called for Leonhart’s removal. Following a speech in which Leonhart was critical of Obama’s assertion that smoking marijuana was no more harmful that drinking alcohol, the Marijuana Policy Project and over 47,000 citizens called for her to resign. A Drug Policy Alliance petition called for her removal following revelations that the DEA had been tracking citizens’ phone calls for decades. Organizations including Students for Sensible Drug Policy and the National Organization for Reform of Marijuana Laws have also called for her resignation.

Though who will be filling in for Leonhart isn’t yet clear, activists say her replacement should be more supportive of ongoing reform initiatives, including reducing mass incarceration and taking the health impact of drugs into consideration when formulating policy. What’s more, Piper says, her removal could lead the Obama administration to reschedule marijuana before the President leaves office.

“This offers a good opportunity for marijuana reform to move forward quicker than it has been moving,” Piper says.

More than that, though, it could signal and even steeper change to policy regarding the enforcement of drug laws. As more states consider legalizing marijuana in some form—23 states have legalized medical use and four have given the green light to toking up recreationally. Six additional states could consider legalization during the 2016 election. As the nation’s stance on that shifts, so too should its approach to drug enforcement, advocates say.

“Within the next 10 years, I see massive drug policy reform and therefore really an end to the DEA,” Franklin says. The new leader, he says, should approach the role as if he or she is “dismantling a decommissioned battleship and selling the pieces for scrap metal.”

“For most part, the DEA exists because they’re enforcing prohibition,” he adds. “I believe we’re moving away from prohibition and more toward health.”

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