Leprosy, the dreaded Middle Ages disease once believed to be a punishment from God, might have afflicted students in Southern California, officials said.

The Jurupa Unified School District — in Riverside County, east of Los Angeles — sent a letter home with kids last week, saying it had an obligation to keep parents informed about the disfiguring skin disease.

“The school district has received an unconfirmed report that two students at Indian Hills Elementary School have been diagnosed with Hansen’s disease (leprosy),” according to the letter inked by district superintendent Elliott Duchon. “In an abundance of caution, (the) administration wanted to share this information with you as soon as possible.”

The letter quoted the US Department of Health and Human Services’ description of leprosy being “not highly transmissible” and “very treatable.”

Leprosy is most associated with the Middle Ages, when those afflicted were cast off from society.

The feared and misunderstood disease has even caused panic in the United States.

A home for leprosy patients was opened in Carville, Louisiana, in 1894, when there was no known medication for the disease. The quarantine hospital and treatment center finally closed in 1999. It’s now home to the National Hansen’s Disease Museum.

Ninety-five percent of people are naturally immune to leprosy, according to HHS.