Democrats have succeeding in fighting off GOP attempts to repeal and replace Obamacare, but now some Democratic senators are indicating an openness to work with Republicans should they succeed in doing away with President Obama's landmark achievement.

'If it makes sense, I think there'll be a lot of Democrats who would be for it, Missouri Senator Claire McCaskill said, told Politico speaking of the replacement part, rather than the repeal.

Republicans will be looking for Democrats to collaborate with them both as a way to put a bipartisan stamp on the effort – and Democrats up for reelection in 2018 might be feeling more pressure at home to participate.

'If they want to change things around the edges, fix some of the things we agree ought to be fixed and call it Trumpcare, that's OK,' Maine independent senator Angus King, who is up in 2018. 'Let's get people covered.'

Senator Joe Manchin of West Virginia , pictured before a meeting with President-elect Donald Trump at Trump Tower, is among those who have expressed a willingness to work on an Obamacare replacement should Republicans succeed in repealing it

Some of the early pressure may fall on Democrats up for reelection in states that Trump carried, some of whom have already made the trek to Trump Tower.

The group includes West Virginia Senator Joe Manchin, North Dakota's Heidi Heitkamp and Jon Tester, Joe Donnelly of Indiana, and McCaskill, an Obama loyalist who represents a swing state.

Manchin, who met with Trump about a possible job and is a likely to be a prime candidate to cooperate with Republicans over the next year, told the publication he is 'going to try to help and be productive' in the event the GOP succeeds in repeal.

Republicans will be facing pressures of their own. Although they have the votes to gut the law's funding mechanism, doing so absent a replacement would risk throwing millions of people off of health insurance and having the GOP on the hook.

President-elect Trump appeared to soften his remarks about repealing and replacing Obamacare after his first meeting with the president in November.

'If it makes sense, I think there'll be a lot of Democrats who would be for it,' McCaskill told Politico of a potential Obamacare replacement

Senator Heidi Heitkamp of North Dakota, pictured at Trump Tower, is among a group of Democrats who will be under pressure to work with Republicans on an Obamacare replacement

'Either Obamacare will be amended, or repealed and replaced,' he told the Wall Street Journal, adding that Obama had asked him to reconsider. 'I told him I will look at his suggestions, and out of respect, I will do that,' Trump added.

Incoming Senate Minority Leader Senator Charles Schumer has said'we’re not going to do a replacement,' but Schumer, who has written about the need to pursue middle class solutions and reach compromises, may fall under pressure to make accommodations with the GOP.