(Bloomberg) — U.S. stocks plunged after a factory gauge fell the most in a decade and Apple cut its sales outlook, adding to concern that global growth is slowing. Treasuries rallied and the yen strengthened.

The S&P 500 Index’s losses approached 2 percent, the Dow Jones Industrial Average sank more than 500 points and 10-year Treasury yields tumbled to an 11-month low after a measure of U.S. manufacturing plunged last month by the most since October 2008. The iPhone maker plunged the most since 2013 after citing an unforeseen slowdown in China for its woes. Bristol-Myers Squibb’s bid to buy Celgene and a strong reading on private hiring for December were shrugged off by bearish investors.

“Corporate America is getting cold feet about the outlook,” said Chris Rupkey, the chief financial economist at MUFG Union Bank in New York. “That’s what the stock market is saying with new selling and new lows after the manufacturing survey’s release.’

Here are the major stocks moves:

Apple plunged as much as 10 percent. All 30 chipmakers in the Philadelphia Semi index fell, with Qorvo, Skyworks and Broadcom off at least 4.5 percent. 3M, Caterpillar and DowDuPont dropped at least 3 percent. Bristol-Myers sank 13 percent, while Celgene jumped to the highest since October. Airlines tumbled after Delta cut its revenue forecast. American was off 8 percent.

In currency markets, the yen jumped as algorithmic programs amplified sharp gyrations amid thin liquidity during a Japanese holiday. Bloomberg’s dollar index fell.

The weak ISM factory reading adds to anxiety spurred by poor data from China and Europe a day earlier, stoking fear that a recession looms larger than previously thought. Apple and Delta join a growing list of companies warning that the trade war and political turmoil may be weighing on corporate profits. Dysfunction in Washington continues, meanwhile, with leaders unable to strike a deal to end a partial shutdown of the federal government.

“That Tim Cook and his company mentioned China as the reason behind the downturn in the company’s outlook seemed to hit exactly the pressure point traders and investors were already alarmed over,” Greg McKenna, markets strategist at McKenna Macro and a three-decade foreign-exchange market veteran, wrote in a note to clients.

Here are some events investors may focus on in coming days:

The U.S. December jobs report is due Friday Fed Chair Powell is interviewed with predecessors Janet Yellen and Ben Bernanke at the annual meeting of the American Economic Association Friday. Atlanta Fed President Raphael Bostic joins a panel on long-run macroeconomic performance.

And these are the main moves in markets:

Stocks

The S&P 500 fell 1.8 percent at 11:11 a.m. in New York. The Nasdaq 100 retreated 2.2 percent, while the Dow Jones Industrial Average slid 533 points. The Stoxx Europe 600 Index lost 0.8 percent. Germany’s DAX Index sank 1.4 percent on the first retreat in a week. The MSCI Emerging Market Index declined 0.8 percent. The Nikkei-225 Stock Average fell 0.3 percent.

Currencies

The Bloomberg Dollar Spot Index dipped 0.4 percent. The euro advanced 0.4 percent to $1.1393. The British pound dipped 0.1 percent to $1.2596. The Japanese yen jumped 1.1 percent to 107.64 per dollar, the strongest in more than eight months.

Bonds

The yield on 10-year Treasuries fell four basis points to 2.58 percent. The two-year Treasury yield fell four basis points to 2.43 percent. Germany’s 10-year yield fell one basis point to 0.15 percent. Italy’s 10-year yield climbed 19 basis points to 2.88 percent.

Commodities

West Texas Intermediate crude fell 0.9 percent to $46.14 a barrel. Gold futures advanced 0.4 percent to $1,289.05 an ounce, reaching the highest in almost seven months on its sixth consecutive advance.

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