The Green Bay Packers might not have Pro Bowl receiver Davante Adams in Kansas City on Sunday night, but nothing about the injury report for Matt LaFleur’s team can compare to the one Chiefs coach Andy Reid is dealing with going into the primetime matchup.

On Friday, the Chiefs ruled out quarterback Patrick Mahomes, left tackle Eric Fisher, left guard Andrew Wylie, defensive lineman Chris Jones, defensive end Frank Clark and cornerback Kendall Fuller.

All six are starters. At least four of them have to be considered within the top tier of the Chiefs’ roster.

Mahomes is the reigning NFL MVP. Fisher made the Pro Bowl last season as a 16-game starter at left tackle. Wylie started the first five games of the season at left guard. Jones was third in the NFL with 15.5 sacks in 2018. Clark had 13.0 sacks for the Seattle Seahawks last season and replaced Dee Ford as the team’s top edge rusher. Fuller broke up 12 passes and was second on the team in tackles last season.

Matt Moore, a 35-year-old veteran with 30 career starts, will replace Mahomes, one of the NFL’s most talented passers. Cameron Erving is expected to play left tackle, a position he hasn’t really played since his senior season in college. Martinas Rankins will start at left guard.

The defense will depend on Alex Okafor, Emmanuel Ogbah and Tanoh Kpassagnon at defensive end. Clark is by far the team’s best edge rusher. There’s no obvious replacement for Jones and his elite pass-rushing ability along the interior of the defensive line, and Fuller’s absence leaves Bashaud Breeland, Morris Claiborne and Charvarius Ward as the expected starters at cornerback.

The Chiefs also listed linebacker Darron Lee as questionable.

It’s possible the Chiefs’ entire inactive list on Sunday night will be starters.

NFL teams overcome important injuries and win games all the time. The Chiefs are talented enough to score points with Moore under center, especially with Reid calling plays, and veteran defensive coordinator Steve Spagnuolo has the aggressive nature to make up for some of Kansas City’s potential pass-rushing issues.

Still, the Packers are going to enter Sunday night’s game with a huge advantage in the health department. They have their MVP quarterback, Pro Bowl left tackle, top edge rusher, top interior rusher and top cornerback all healthy. The Chiefs don’t.