Marco Rubio's number one fan couldn't hide her enthusiasm during Thursday's debate in Texas at the University of Houston.

One woman in the crowd could be heard several times throughout the evening letting out a high-pitched shriek combined with a squeal.

The unidentified woman seemed to make the unique sound for only one candidate though - Florida Senator Marco Rubio.

The 44-year-old presidential hopeful gave his strongest debate performance yet, as he ripped Donald Trump for his use of illegal immigrant workers to build Trump Towers among other namesake buildings and sites.

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People took to Twitter to express how they felt about the unidentified woman screaming for Rubio

Twitter user @Luke_Berti questioned if the woman screaming for Rubio was dying in the audience

Twitter users were not shy with their criticism of the sharp sounds coming from the mystery woman, as many people were not pleased

Twitter user @KPhed even suggested that the woman screaming for Rubio be tranquilized

The woman in the crowd could be heard several times throughout the evening letting out a high-pitched shriek combined with a squeal - especially when Senator Marco Rubio spoke

'If he hadn't inherited $200 million, do you know where Donald Trump would be? Selling watches in Manhattan!' Rubio said.

He also hit out against Trump for having the clothing apparel and ties apart of his brand made in Mexico - a country that he has spoken out against since launching his presidential campaign.

While Rubio came at the Donald hard, the mystery woman in the audience would scream loudly for him seemingly dominating all of the other audience members.

Twitter users were not shy with their criticism of the sharp sounds coming from the mystery woman, as many people were not pleased and fired off angry tweets about her.

The 44-year-old presidential hopeful gave his strongest debate performance yet, as he ripped Donald Trump for his use of illegal immigrant workers to build Trump Towers among other namesake buildings and sites

Twitter user @JimDelRey questioned who the woman was 'squealing at every Rubio one-liner' during the debate

Another user even jokingly asked, 'Is the lady in the crowd who keep screaming Marco Rubio's mom?'

One user under the Twitter handle @mpopv wrote: 'Rubio we know you love America but bringing in an actual eagle to shriek every time you say something might have been taking it a bit far'.

'Who is the screaming lady squealing at every Rubio one-liner? #GOPDebate,' Twitter user @JimDelRey wrote on the social media site.

Another person wrote: 'Someone tranquilize the screaming Rubio lady in the crowd please. #GOPDebate'.

One person even jokingly asked, 'Is the lady in the crowd who keep screaming Marco Rubio's mom? #GOPDebate'.

Several people suggested that the woman screaming should stop as the sound was very high pitched

The person above referred to the mystery woman as a 'shrieking monster'

Another Twitter user said the lady screaming sounded like she was at Springsteen concert

It seemed as though the woman screamed more profusely for Rubio in the first block of the debate than at any other point of the night.

As soon as the night started, Rubio surprisingly hit out with his fiery comments to Trump, as Sen. Ted Cruz piled on with some critiques of his own against the billionaire businessman.

The other two remaining candidates, Ben Carson and John Kasich, were largely left to watch the fireworks flying overhead during the shouting match between Trump, Rubio and Cruz.