Michelle Pfeiffer and Annette Bening have signed on to star in director Gideon Raff’s thriller “Turn of Mind,” Rocket Science announced Friday.

Rocket Science will finance the film and launch international sales at Cannes, with CAA Media Finance representing the U.S. domestic rights.

The psychological thriller is centered around a retired orthopedic doctor suffering from Alzheimer’s who, in her moments of clarity, is trying to figure out if she killed the person the police claim she had, or if she’s being deceived.

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Based on Alice LaPlante’s New York Times bestseller of the same name and adapted by Pulitzer Prize winner Doug Wright, the film will be produced by Gail Berman through The Jackal Group, Well Told Entertainment’s Rory Koslow, and Gideon Raff.

“‘Turn of Mind’ is an edge of your seat emotional thriller. A story of a warped friendship between two brilliant, sharp, forceful women who are bonded equally by their love for and jealousy of one other,” Raff said. “I am thrilled to have two legends filling these roles. What struck me most when reading LaPlante’s novel was how she rarely breaks from Jennifer’s (Bening) point of view. So, with her, we go through the visceral experience of a woman who relied her whole life on her gifted mind, only to find herself losing it when she needs it most.”

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Pfeiffer will next be seen opposite Angelina Jolie and Elle Fanning in Disney’s “Maleficent: Mistress of Evil,” which is hitting theaters Oct. 18. Bening is currently starring in Disney’s “Captain Marvel.”