In a new sign of tumult within Anthony D. Weiner’s embattled political operation, his campaign manager has quit, leaving his already skeletal team without a day-to-day leader.

According to two people told of the decision, the campaign manager, Danny Kedem, no longer wished to oversee Mr. Weiner’s bid for New York mayor after a week of bruising revelations about the candidate’s latest online conduct. The two people, who have close ties to the campaign, did not want to be identified because they were disclosing confidential conversations.

Mr. Kedem, 31, informed Mr. Weiner of his decision in the last 24 hours, the two people said.

Mr. Weiner confirmed the news on Sunday morning outside of a Brooklyn church where he was campaigning. “Danny has left the campaign. He did a remarkable job,” Mr. Weiner said.