It can get complicated. Nancy Bento, who lives across the street, has gone to Nashville and Puerto Rico with Dan and Mary Eccles, whom she met here, and who met each other after being introduced three years ago by Scott Chandley, the beloved bartender. Mr. Chandley was the best man at their wedding. On a recent Friday night, they all celebrated Mr. Chandley’s birthday at the bar with a cake and candles

Mr. Bowne, a dentist with a practice a few blocks away on Madison Avenue, has been coming to Gabriel’s for 27 years, the year after it opened, back before the Time Warner Center arrived, when the neighborhood was not so well lit and was slightly dangerous, shattered car window glass sparkling on the sidewalk from break-ins. Now Dr. Bowne does everyone’s teeth. In his office, of course.

Cheryl McKissack Daniel, who runs the oldest African-American-owned architecture and engineering firm in the country, McKissack & McKissack, uses Gabriel’s as her kitchen since her husband went vegan. “I can’t deal with his vegan stuff,” she said.

Mr. Aiello, who never leaves, and Scott, the bartender, help facilitate introductions and keep the conversation and martinis flowing. But this summer, the party will come to an end — at this address anyway. The landlord is demolishing the building to make way for a high-rise condominium.

“We all have to be out by July 31,” said Mr. Aiello, who has already broken the news to the regulars. Mr. Aiello is hoping to move to a new place a block away and has faith the faithful will follow.

Ms. Kirchhausen has no doubt Gabriel’s will be a movable feast. “This,” she said, “is our chosen family.”