Date Event, if any Peculiarities

January 1 New Year's Starts with 99 bombs (not Pyro blindfolded. Only bomb items can be found in Treasure Room Item Pool.

January 16 National Nothing Day Apollyon, no item rooms, no shops.

February 2 Groundhog Day Same character as the day before.

February 11 National "Don't Cry Over Spilled Milk" Day Magdalene, starts with Milk! Soy Milk

March 17 St. Patrick's day Cain to Mega Satan, starts with 18 luck.

March 22 National "Goof off" day Isaac, starts with extreme range; tears follow random patterns.

April 1 April fools Old Man Keeper, random trinkets and items upon pickups.

May 30 Memorial day The Lost, no tears, 3 familiars and Conjoined.

June 18 Fathers' day Cain, starts with A Dollar

June 25 Pride day The Lost, rainbow items.

July 2 I Forgot Day ???, starts with Forget Me Now

August 16 National Tell a Joke day The Keeper, every pill is Explosive Diarrhea.

September 17 National Apple Dumpling day Cain, every boss item is Apple!

October 7 Isaac to The Cathedral. Starts with Chaos

October 31 Halloween Eve, starts with Sack Head

November 11 Veterans' day The Lost, no item rooms.