The slogan "Death to America" is not aimed at the American people, but rather American policies, Iran's supreme leader said in comments reported on his official website Tuesday.

Ayatollah Ali Khamenei discussed the slogan while meeting with Iranian students ahead of the anniversary of the takeover of the U.S. embassy in Tehran on November 4, 1979. Militant students stormed the compound and took 52 Americans hostage for 444 days.

Open gallery view Ayatollah Ali Khamenei speaks during a meeting with students in Tehran, Iran, Tuesday, Nov. 3, 2015. Credit: AP / Office of the Supreme Leader

The two countries have had no diplomatic relations since then. However, current President Hassan Rouhani has made efforts to improve relations, including a landmark nuclear agreement reached with world powers this past summer.

Khamenei says the "aim of the slogan is not death to American people. The slogan means death to U.S. policies and arrogance." The slogan has "strong support" in Iran, he said.

Khamenei and hard-liners in the Iranian government remain deeply suspicious of the United States and view its policies a threat to the country.

He reiterated his warning that the U.S. is not to be trusted despite the nuclear deal reached with the U.S., Britain, France, Russia, China and Germany. The agreement promises Tehran relief from crippling economic sanctions in exchange for curbs on its nuclear program.

He said the U.S. "will not hesitate" if given a chance to destroy Iran. "The nature of the U.S. attitude is continuation of the same hostile aims from the past, and the nation will not forget this," Khamenei said.