The May 2018 rift intrusion and eruption of Kīlauea Volcano, Hawai‘i, represented one of its most extraordinary eruptive sequences in at least 200 years, yet the trigger mechanism remains elusive1. The event was preceded by several months of anomalously high precipitation. It has been proposed that rainfall can modulate shallow volcanic activity2,3, but it remains unknown whether it can have impacts at the greater depths associated with magma transport. Here we show that immediately before and during the eruption, infiltration of rainfall into Kīlauea Volcano’s subsurface increased pore pressure at depths of 1 to 3 kilometres by 0.1 to 1 kilopascals, to its highest pressure in almost 50 years. We propose that weakening and mechanical failure of the edifice was driven by changes in pore pressure within the rift zone, prompting opportunistic dyke intrusion and ultimately facilitating the eruption. A precipitation-induced eruption trigger is consistent with the lack of substantial precursory summit inflation, showing that this intrusion—unlike others—was not caused by the forceful intrusion of new magma into the rift zone. Moreover, statistical analysis of historic eruption occurrence suggests that rainfall patterns contribute substantially to the timing and frequency of Kīlauea’s eruptions and intrusions. Thus, volcanic activity can be modulated by extreme rainfall triggering edifice rock failure—a factor that should be considered when assessing volcanic hazards. Notably, the increasingly extreme weather patterns associated with ongoing anthropogenic climate change could increase the potential for rainfall-triggered volcanic phenomena worldwide.