“Zootopia” is set to run away with the No. 1 spot at the weekend box office, again.

The film is expected to add another $48 million in box office receipts this weekend, according to estimates from Box Office’s Daniel Garris. That would push “Zootopia” past the $100 million mark.

The film, about a spunky rookie bunny cop named Judy Hopps who’s working to uncover a conspiracy among anthropomorphic animals, beat out 2013’s “Frozen” to post the best opening for a film from Walt Disney Co.’s Animation Studios DIS, -1.22% .

See also:‘Zootopia’ beat out ‘Frozen’ for Disney Animation’s No. 1 opening weekend

Film Clip: 'Zootopia'

“Zootopia” should have no trouble outpacing the weekend’s major box office releases: “10 Cloverfield Lane,” from Viacom Inc.-owned US:VIA US:VIAB Paramount Pictures, and Sony Pictures Entertainment’s SNE, +1.73% “The Brothers Grimsby.”

“[‘Zootopia’] was off to a terrific $75.1 million start this past weekend and is likely to hold up well thanks to very strong early word of mouth and the lack of any new animated films entering the marketplace,” Garris wrote.

“10 Cloverfield Lane” is based on the story from 2008’s cinéma vérité-style film “Cloverfield.” Analysts at Box Office, led by Garris, expect the film to garner $24 million in its opening weekend. Reviews have been positive, and the tie to “Cloverfield,” which brought in $80 million domestically on a $25 million production budget, has helped the buzz.

Weekend top 10 box office estimates Rank Title Distributor Weekend estimate (millions) Estimated domestic gross (millions) 1 “Zootopia” Disney $48.0 $141.0 2 “10 Cloverfield Lane” Paramount Pictures $24.0 $24.0 3 “Deadpool” 20th Century Fox $10.2 $327.4 4 “London Has Fallen” Focus Features $9.8 $35.3 5 “The Young Massiah” Focus Features $6.7 $6.7 6 “The Brothers Grimsby” Sony Pictures $5.5 $5.5 7 “The Perfect Match” Lions Gate $4.5 $4.5 8 “Whiskey Tango Foxtrot” Paramount Pictures $3.9 $13.8 9 “Risen” Sony Pictures $2.4 $32.5 10 “Gods of Egypt” Lions Gate $2.3 $27.1 BoxOffice.com

Sacha Baron Cohen’s “The Brothers Grimsby” is expected to earn $5.5 million in its debut, falling short of the weekend’s top five films. Baron Cohen’s previous two films “The Dictator” and “Brüno” grossed a combined $119.8 million domestically at the box office.

Also opening in wide release this weekend is the story of a young Jesus Christ “The Young Messiah.” Garris expects the film to garner $6.7 million for Focus Features, which is the art house studio of Comcast Corp.-owned CMCSA, -0.70% NBCUniversal. Lions Gate Entertainment Corp. US:LGF will debut romantic comedy “The Perfect Match,” which is expected to bring in $4.5 million this weekend.

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Box Office analysts forecast the top 10 films from the weekend will total $117.3 million, a slight 1.5% increase compared with $115.6 during the same weekend last year. The overall box office is up 6.7% in the year to date so far.