Background Many therapeutic modalities were reported for the treatment of warts; however, no single treatment is completely effective.

Objective To evaluate the efficacy of intralesional injection of MMR vaccine vs vitamin D in treatment of warts.

Patients and Methods A total of 60 patients were included in the study divided into two groups. Group A received intralesional MMR vaccine into largest wart, and group B received intralesional vitamin D 3 into each lesion with maximum of five warts treated in one session. A maximum of six sessions was done every 3 weeks in both groups. Follow‐up was done for 6 months for any recurrence.

Results In group A: complete response in 80%, partial response in 6.67%, minimal response in 6.67%, and no response in 6.67% of patients. About 60% of patients with multiple warts showed complete clearance of distant untreated warts. In group B: complete response in 66.7%, partial response in 6.67%, minimal response in 20%, and no response in 6.67% of patients. There was no significant difference between both groups. No recurrence was observed in both groups in the follow‐up period.