After 2010, when oxycodone – a high-dose opioid painkiller sold as OxyContin – was switched by its manufacturer to a new abuse-deterrent formulation, overdose rates fell substantially, researchers have found.

Share on Pinterest In addition to potential misuse by people receiving the original prescription, opioid painkillers may be diverted to illicit users.

The formulation change also saw a drop in the levels of dispensing, and the lower opioid overdose and prescribing levels also correlated with the withdrawal from the market of another narcotic drug in the same year, propoxyphene.

OxyContin is an extended-release formulation to deliver its higher painkilling dose in a more controlled way, but misuse of this opioid for a quicker “high” had been possible by crushing or dissolving the medication to bypass this design. The new formulation, however, is resistant to this abuse strategy.

Propoxyphene (Darvon) was withdrawn from the US market in 2010 because of data about its cardiac side-effects. First approved for sale as an analgesic in 1957, it soon became prone to misuse – and the authors cite that, by 1977, propoxyphene was the “second-leading agent in prescription drug-induced deaths.”

The authors of the study in JAMA Internal Medicine describe the reduction in dispensing following these two pharmaceutical industry changes in 2010: