Substance Published FR Citation Effective CSA Schedule NALOXONE HCl 09-29-71 36 FR 19116 9-29-71 II -> 0 NALOXONE 12-24-74 39 FR 44392 12-24-74 II -> 0 NALTREXONE 03-06-75 40 FR 10455 3-6-75 II -> 0 APOMORPHINE 06-28-76 41 FR 26568 6-28-76 I -> 0 DEXTRORPHAN 10-01-76 41 FR 43401 10-1-76 II -> 0 NALBUPHINE 10-01-76 41 FR 43401 10-1-76 II -> 0 LOPERAMIDE 11-03-82 47 FR 49840 11-3-82 V -> 0 NALMEFENE 11-04-85 50 FR 45815 11-4-85 II -> 0 MDMA 01-27-88 53 FR 2225 1-27-88 I -> 0 But later... 02-22-88 53 FR 5156 3-23-88 back to I PROPYLHEXEDRINE 12-03-91 56 FR 61372 12-3-91 V -> 0 FENFLURAMINE 05-06-97 -- -- IV -> 0 But later... 05-15-03 68FR26247 5-15-03 back to IV, withdrew the 1997 proposed rule BUTORPHANOL (thebaine derived) 07-14-92 57FR31126 7-14-92 II -> 0 But later... 10-01-97 62FR51370 10-31-97 placed in IV TFMPP 03-18-04 69 FR 12794 03-19-04 I --> 0 THENYLFENTANYL* 10-29-85 50FR43698 11-29-85

(expired 11-29-86) I -> 0 BENZYLFENTANYL* 10-29-85 50FR43698 11-29-85

(expired 11-29-86) I -> 0 BETA-HYDROXY-3-METHYL-FENTANYL** 11-26-86 51FR42834 11-29-86

(expired 5-29-87) I -> 0 * : Temporarily Scheduled under 21 USC 811(h) ** : Extension of temporary control

The following table is a compilation of every drug/substance that has at one time been controlled under the U.S. Federal Controlled Substances Act (CSA) and was then subsequently removed from control. Some of these, like naloxone, were scheduled on the basis of their chemistry alone (it's a derivative of Schedule II thebaine) and were decontrolled after HHS analysis showed they had no abuse potential. Others did not move from temporary to permanent scheduling because an HHS scientific evaluation failed to show abuse potential, leading to expiration of the temporary scheduling action. Oor, with MDMA, the drug was rescheduled after initial decontrol, despite a complex administrative law process.A few were removed from control and then later controlled again, such as Fenfluramine, MDMA, and Butorphanol. This table is derived from the DEA's Chronology of Scheduling Actions: http://www.deadiversion.usdoj.gov/schedules/orangebook/b_sched_chron.pdf