The battle for the Liberal leadership is on after senior ministers Mathias Cormann, Michaelia Cash and Mitch Fifield abandoned Prime Minister Malcolm Turnbull, informing him that they believe he no longer holds majority support in the Liberal party room.

The trio joined a string of other ministers, including cabinet members Steve Ciobo, Greg Hunt and junior ministers Angus Taylor and Alan Tudge in quitting the frontbench.

The resignations pave the way for Peter Dutton and Scott Morrison to battle it out for the leadership, at a meeting that could be held as late as Monday, if Malcolm Turnbull decides to step aside.

The trio of ministers sealed the Prime Minister's fate at a press conference on Thursday morning after visiting Mr Turnbull to inform him they believe he needs to call a meeting of Liberal MPs to resolve the matter "swiftly".

Their decision means a change is imminent with two former immigration ministers - Mr Dutton and Mr Morrison - confirmed candidates.