The exhibition is a commercial venture, overseen by Jeffrey Seller, who is the musical’s lead producer, and designed by David Korins, who is the musical’s set designer. It has been capitalized for $13.5 million, according to a filing with the Securities and Exchange Commission — more than the cost of the original Broadway musical, which was $12.5 million. Tickets are $39.50 for adults, $25 for children and free for Chicago public school groups.

The show is betting that interest in “Hamilton” remains so high, both among those who have seen the show and those who have not, that it can sustain the exhibition here for months and then move it to another location — San Francisco or Los Angeles are “logical options,” Mr. Seller said. It is built to tour, although it will require space — the exhibition occupies 35,000 square feet in a hangar-like structure that is 300 feet long and 100 feet wide — and expense: Moving it will take 80 trucks, compared to just seven to move a touring production of the show.

The exhibition is starting in Chicago in recognition of the musical’s success here, where the first production outside New York opened in 2016, and the musical has now been seen by more people in Chicago than in New York.