An elderly wheelchair-bound man has been killed and his wife badly injured after a dog attack at a home in Melbourne's north.

Police were called to a home at Ancona Drive in Mill Park at about 6.30pm on Wednesday, where they found the body of a man believed to be in his 60s.

The man's wife, also in her 60s, was found with serious injuries to her upper body.

An elderly wheelchair-bound man has been killed and his wife badly injured after a dog attack at a home in Melbourne 's north. Pictured: Police outside the home

Emergency services were called to a home at Ancona Drive (pictured after the incident) in Mill Park about 6.30pm on Wednesday, where they found the body of a man believed to be in his 60s

She was rushed to the Royal Melbourne Hospital where she remains in a stable condition.

Police spent hours trying to catch the American Staffordshire Terrier before removing it from the home with an animal control pole.

RSPCA officers put the dog in a cage and drove it away at about 10.30pm.

Senior Sergeant Glenn Parker said the dead man's daughter-in-law has given consent for the dog to be put down.

The dog belongs to the occupant's son, the dog's been here for quite some time,' he said at the scene.

'The dog will be taken to a veterinarian, and my understanding is that the owner of the dog has actually consented to that dog being put down.

'It's quite familiar with all of the members of the family and my understanding is it's out of character for the dog.'

The man who was killed was using a wheelchair.

Police said he had recently injured himself, so he was relying on crutches and the wheelchair to move.

Several witnesses in the neighborhood spoke of hearing 'deafening' screams about the time of the ordeal.

One male neighbour told the Herald Sun he tried to hose the dog with water.

'There was no stopping it,' he said, adding that it was 'giant'.

Another witness said that the dog 'was going nuts'.

Neighbours say they would often hear the dog barking but it had never caused any trouble.

Victoria Police said they are still investigating the circumstances of the incident.