Senators have hurled insults at each other as a marathon debate continues in Federal Parliament over Senate voting changes.

The Upper House has spent the night in an intractable debate about the contentious overhaul of voting laws, with the Federal Government ruling that Parliament will not rise until the bill is passed.

The bill is set to pass, with the Government to gain the support of the Greens and independent senator Nick Xenophon.

But the Coalition does not have the numbers to gag debate and bring on a vote.

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Debate has continued into this morning, with the Finance Minister Mathias Cormann threatening to keep Parliament sitting until the weekend and beyond if required.

"If you still want to be here on Easter Friday, on Good Friday, that's fine," he said.

"Let's be here on Easter Friday, we will be here until this legislation is dealt with."

Labor senator Deb O'Neill has vowed the Federal Opposition will not give up the fight against the changes.

"That is exactly what this Government would like us to do, just for us to go home, just to let this filthy deal go through without the scrutiny it deserves," she said.

"But we will not allow that to happen."

Labor and most of the crossbench are against the changes and have spent much of the sitting week attempting to stymie debate on the measures.

The Federal Opposition claims the measures will make it easier for the Coalition to gain the balance of power in the Senate, while the Government and the Greens say it will give voters greater power over their preferences.

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Labor senator Penny Wong has lashed out at the Greens for supporting the Government's changes.

"What about the dirty deal that [Liberal Party powerbroker] Michael Kroger has blown the whistle on? That this leader, the Liberal lap dog that is Senator Di Natale, the Liberal lap dog has done a deal," she said.

Greens leader Richard Di Natale has told Parliament the changes are vital to improving the democratic process.

"We are often fighting against the slow and gradual erosion of democracy," he said.

"What a great day, what a great day, when we can say that today we have stood up, that's we've strengthened our democracy, and we've given more power back to the people," he said.

Independent senator Jacqui Lambie questioned whether the changes would survive a High Court challenge.

But Senator Cormann said the measures were legally sound.

"We are very confident that our reform proposal is consistent with all of the relevant requirements in the constitution," he said.

The House of Representatives will have to sit on Friday to rubber-stamp the bill if it passes the Senate.

Independent senator Nick Xenophon entered the chamber during a procedural vote wearing pyjamas, but was told by attendants he should change his clothes.