NASHVILLE, Tenn. -- Step aside, VCU. Enjoy your memories, Butler. Ohio's ready to become the latest mid-major darling of March Madness.

Walter Offutt scored 21 points, D.J. Cooper had 19 and No. 13 seed Ohio beat South Florida 62-56 on Sunday night to advance to the Midwest Regional semifinals.

"This is amazing," said Offutt, a transfer from Ohio State by way of Wright State. "It's one thing to talk about it and one thing to actually do it. This has been unreal, but let's just continue the run."

Ohio is the seventh team seeded No. 13 or higher to advance to the regional semifinals and the first since No. 13 Bradley did it in 2006. None of those teams won its next game.

The Bobcats (29-7), who opened the tournament with an upset against fourth-seeded Michigan, will play No. 1 seed North Carolina in St. Louis on Friday in their first trip to the round of 16 since they lost to the Wolverines in the regional finals in 1964.

Ohio trailed by two when Offutt swished a 3-pointer, launching a 10-0 run for the Bobcats. A pair of free throws by Cooper made it 54-46 with 3:28 left.

The Bobcats had a 59-53 lead when Toarlyn Fitzpatrick connected for South Florida's first 3-pointer of the half. But Cooper went 3 for 4 from the line while the Bulls missed three shots in the final 36 seconds.