The inevitable has happened.

On Location Tours, which sends busloads of tourists every day to Manhattan streets that have appeared on screen, is contemplating a tour of Brooklyn, based on “Girls,” the HBO series closely identified with the borough.

It is another sign of how far Brooklyn’s fortunes have risen. “Girls” and, before it, movies like Spike Lee’s “Do the Right Thing” have been able to claim a measure of homegrown authenticity, since their creators lived in Brooklyn. But the wave of movie, advertising and especially television filming that has inundated the borough in recent years, glorifying its leafy neighborhoods and cultural cachet, has swept it into the mainstream, the big-budget and the touristy.

By now, Brooklynites have discovered what Manhattanites have long known: Filming can be a messy, intrusive business. Over the winter, the mayor’s office declared a moratorium on filming in part of Brooklyn Heights after residents grew tired of disruptions.

And the chasm between reality and the big screen is wide indeed.

Even as young filmmakers continue making web series about the strivings of post-college Brooklynites, major directors and corporate advertisers are turning to Brooklyn in record numbers. They are drawn in part by the increasing convenience of filming in a borough with a diverse array of streetscapes and two major studios just across the East River from Manhattan. But more and more of their characters live there, too — whether in the sleek pages of a West Elm catalogue or in the new ABC prime-time series “Black Box.”