The Foundation reports that it works with businesses, governments, nongovernmental organizations, and individuals to improve global health and wellness, reduce childhood obesity, create economic opportunity and growth, inspire civic engagement and service, and help communities address the effects of climate change by implementing programs, facilitating opportunities and forming creative partnerships. The Clinton climate initiative collaborates with governments and partners to increase the resiliency of island nations and territories facing climate change by creating and implementing replicable and sustainable renewable energy sources. The Clinton development initiative creates economic opportunities for farmers by helping them increase their production and grow their businesses in Malawi, Rwanda, and Tanzania. The Clinton global initiative convenes leaders from the private sector, public sector, and civil society to create and implement solutions to pressing problems around the world. Building on the model of the Clinton global initiative, President Clinton launched the Clinton Global Initiative University (CGI U) to engage the next generation of leaders on college campuses around the world. The Clinton health matters initiative works to improve the health and well-being of people across the U.S. by activating individuals, communities, and organizations to make contributions to the health of others. The Foundation also runs the William J. Clinton Presidential Center and Park, an educational and cultural venue offering a variety of special events, exhibitions, educational programs, and lectures throughout the year. The Foundations Too Small to Fail is leading a national public awareness and action campaign to promote the importance of early brain and language development and to support parents with tools to talk, read, and sing with their young children from birth. Finally, the Alliance for a Healthier Generation empowers kids to develop lifelong healthy habits by ensuring the environments that surround them provide and promote good health.

For the year ended December 31, 2016, Clinton Foundation's program expenses were: