Two men and a woman are dead after fire tore through a home at Everton Hills in Brisbane's north on Tuesday morning.

The blaze broke out at the Pavonia Street home about 5:30am, with authorities alerted by a triple-0 call.

Police say the fire is being treated as suspicious and forensic officers are expected to spend several days examining the scene.

Detective Acting Inspector Joe Zitny said several signs had aroused police suspicions. ( ABC News )

Detective Acting Inspector Joe Zitny said on Tuesday afternoon police had not yet identified any of the victims.

He said they were seeking assistance from anybody who saw or heard "anything remarkable" in the 24 hours leading up to the fire.

"There was a set of circumstances that as we are investigating them there's been one or two signs that have indicated and aroused our suspicions and we're pursuing those lines of inquiry," he said.

"Any people that may have noticed anything or saw something remarkable, or something out of place, or something different, in the vicinity of Pavonia Street in Everton Hills … please make contact with Crime Stoppers."

Inspector Zitny said the house had been "significantly damaged", and as a result it had taken several hours for police to gain access.

"Our forensic people are scouring the crime scene as we speak," he said.

"It's anticipated it's going to be a number of days … to finalise what we describe as the crime scene of the house."

Fire crews said at one point the flames were twice as high as the house. ( Supplied: Peter George )

Asked about reports cars were seen speeding away from house after the fire started, Inspector Zitny said that was one of several lines of police inquiry.

"The crime scene is presenting a number of barriers to the authorities at present. We're slowly but surely working through those barriers and we'll certainly conduct the identification process as soon as we can," he said.

Earlier, Inspector Dan Bragg said neighbours reported hearing an explosion coming from the home.

"What we're advised is that it was quite a large explosion, quite significant, and the neighbour that heard that explosion immediately contacted police," he said.

"We also spoke to one neighbour who gave us advice that there was some yelling beforehand."

Neighbour Lindsay Ostrofski could see the fire from his verandah.

"[There] was just a whole pillar of smoke going straight up … flames had engulfed all of the underneath of the house — she just went up," he said.

Sorry, this video has expired Queensland Police say an explosion was reported at the scene of a deadly house fire

Mr Ostrofski said his wife heard an explosion and a woman screaming for help.

"When we went out we couldn't do nothing, it was just pure flames," he said.

Mr Ostrofski said his neighbours had been living at the house for about three years and the news of their death was "upsetting".

"They kept to themselves … it's a nice neighbourhood a good quiet street," he said.

Member for Everton Tim Mander said the incident had been a "total shock" to the neighbourhood.

"This is a really peace-loving suburb — everybody gets on well with each other," he said.

"Our heart goes out to the families of the three victims and the neighbours that are obviously very close to this tragedy.

"If it was seen in the end that there were suspicious circumstances involved, that would be a real shock to the community."

Queensland Fire and Emergency Service Inspector Bevan Moore said several witnesses reported hearing "unusual noises".

"Explosions reported by neighbours, the smell of fuel and things like that," he said.

Inspector Bragg said it was believed the fire broke out quite quickly.

"I've heard the fire could be seen from quite a distance away," he said.

"And it was the flames and smoke that actually led people to the address.

"At this stage we do not know what happened here … we have to get to the bottom of it quite soon.

It took six fire crews to bring the blaze under control. ( ABC News: Kristian Silva )

"Screams were heard for help but exactly where those screams were coming from … is yet to be ascertained."

Six crews worked to douse the blaze in the brick home and have now brought it under control.

Inspector Moore said at one point the flames were twice as high as the house.

"You can tell by the damage it was a significant fire and significant heat," he said.

He said crews who were involved would receive support.

"It is difficult for crews when they're confronted with such a tragedy such as this … it does play on people's mind," he said.

Sorry, this video has expired Neighbours heard an explosion before fire tore through this Brisbane home

Police have evacuated other homes in the suburban street and surrounding areas and closed the road.

But Inspector Bragg said no other homes were damaged.

"Which is quite extraordinary considering the extent of damage to that house and the size of smoke and flames emanating from the residence," he said.