Manny Ramirez and David Ortiz, the sluggers who helped the Boston Red Sox end an 86-year World Series championship drought and capture another title three years later, were among the roughly 100 Major League Baseball players to test positive for performance-enhancing drugs in 2003, according to lawyers with knowledge of the results.

Some of baseball’s most cherished story lines of the past decade have been tainted by performance-enhancing drugs, including the accomplishments of record-setting home run hitters and dominating pitchers. Now, players with Boston’s championship teams of 2004 and 2007 have been linked to doping.

Baseball first tested for steroids in 2003, and the results from that season were supposed to remain anonymous. But for reasons that have never been made clear, the results were not destroyed and the first batch of positives has come to be known among fans and people in baseball as “the list.” The information was later seized by federal agents investigating the distribution of performance-enhancing drugs to professional athletes, and the test results remain the subject of litigation between the baseball players union and the government.

Five others have been tied to positive tests from that year: Barry Bonds, Alex Rodriguez, Sammy Sosa, Jason Grimsley and David Segui. Bonds, baseball’s career home runs leader, was not on the list, although federal agents seized his 2003 sample and had it retested. Those results showed the presence of steroids, according to court documents.