The cruelest day of the NFL’s long calendar arrived Saturday with teams setting their 53-player rosters.

Among the more prominent dismissals were Bills veteran running back LeSean McCoy, backup QBs Brian Hoyer in New England and Kevin Hogan in Denver, and receivers Laquon Treadwell of the Vikings, Demaryius Thomas of the Patriots and Josh Doctson of the Redskins.

Bills GM Brandon Beane cited the emergence of rookie RB Devin Singletary in the team’s surprising decision to cut the 31-year-old McCoy.

“It was very difficult,” Beane said. “I believed in LeSean the whole time and again, it was down to the last minute we decided to go in this direction.”

In other notable moves: