SEATTLE -- The San Francisco 49ers will be without defensive tackle Justin Smith because of an elbow injury, ending his streak of consecutive starts at 185.

With Smith out, the 49ers will start Ricky Jean Francois at defensive end against the Seattle Seahawks on Sunday night. The 49ers will also be without backup linebacker Clark Haggans with a shoulder injury.

Both Smith and Haggans were questionable, but San Francisco did have receiver Mario Manningham active despite a shoulder injury.

Seattle was without starting right guard John Moffitt, who was not listed on an injury report this week.

Rookie J.R. Sweezy started in his place. Seattle was also without cornerbacks Walter Thurmond and Marcus Trufant, both with hamstring injuries. Rookie Jeremy Lane will start his second straight game at cornerback.

Wide receiver Sidney Rice was active for Seattle after being questionable with a knee injury.