EMBED >More News Videos El Chapo's son Ovidio Guzman was the target of a raid by Mexican security forces on Oct. 17 that went sideways.

WASHINGTON -- President Donald Trump put the Mexican government on the defensive when he said he "absolutely" will move ahead with plans to designate Mexican drug cartels as terrorist organizations.Trump said in a radio interview this week that tens of thousands of Americans are killed every year because of drug trafficking and other activity by the cartels. But Mexico is pushing back, worried that such a step would allow its neighbor to the north to violate its sovereignty by operating unilaterally inside Mexico."I've been working on that for the last 90 days," Trump said in a radio interview with Bill O'Reilly, who asked whether such a designation would be forthcoming.O'Reilly had asked Trump if he would designate the cartels "and start hitting them with drones and things like that?"Trump replied: "I don't want to say what I'm going to do, but they will be designated."Mexican President Andrés Manuel López Obrador said Wednesday that he did not want to enter a "political confrontation" with the U.S. government on the eve of its Thanksgiving holiday. He said that he would leave it at "cooperation, yes; interventionism, no," and that he had instructed Foreign Secretary Marcelo Ebrard to explain Mexico's position to Washington.Ebrard later tweeted that he'd already been in contact with the U.S. government and would use diplomacy to "defend sovereignty."Trump offered no timetable for the designation. After the U.S. labels an individual or organization as a terrorist group, it then becomes illegal for anyone in the United States, including banks and other financial institutions, to knowingly provide them with support. Members of terrorist groups are also denied entry into the U.S.Authorities suspect Mexican drug cartel hit men in the shooting deaths of nine American women and children in northern Mexico earlier this month as they traveled in vehicles to visit relatives.After the attack, Trump tweeted: "This is the time for Mexico, with the help of the United States, to wage WAR on the drug cartels and wipe them off the face of the earth."Trump said in the radio interview that López Obrador had rejected his offer to "let us go in and clean it out" but that "at some point, something has to be done.""Look, we're losing 100,000 people a year to what's happening and what's coming through on Mexico," Trump said, speaking of American lives. "And they have unlimited money, the people, the cartels, because they have a lot of money because it's drug money and human trafficking money."In rejecting Trump's approach, López Obrador said previous Mexican administrations had declared war "and it didn't work."Ebrard's office said Tuesday that he would get in touch with Secretary of State Mike Pompeo to discuss the subject and seek a high-level meeting as soon as possible.The foreign minister noted Monday that a terrorist designation carries legal implications and that American law would then allow the U.S. government to act "in a direct way" against those groups."That, of course, Mexico would never accept," Ebrard said. While the U.S. and Mexico have a history of cooperation in combating the cartels, principally through sharing intelligence, Mexico's concern would be that U.S. forces would potentially move against targets independently, violating Mexico's sovereignty.Mexico's Senate president, Ricardo Monreal, a member of the president's party, said via Twitter on Tuesday night that the designation would allow the U.S. government "to use legal and institutional means that would permit it to act unilaterally in our territory with the justification of pursuing those groups."