The head of the state Republican Party called Thursday for a criminal investigation of Gov. Cuomo over allegations that a former top aide kept using his state office in Manhattan while working on Cuomo’s 2014 re-election campaign.

GOP Chairman Edward Cox filed a written complaint with Manhattan DA Cyrus Vance Jr., then held a news conference outside the federal courthouse where ex-Cuomo aide Joseph Percoco is being tried on corruption charges.

Cox said state laws “make it very clear that a public officer or a private citizen cannot use a public office to conduct private business or political activity — and that is clearly, on the basis of sworn testimony and hard evidence presented in the trial in the courthouse behind us, what Joe Percoco did.”

“The governor must have known that that office should not have been used by a private citizen to conduct political activity or personal business activity as Joe Percoco was doing,” Cox added.

“The issue really is not whether Joe Percoco can be indicted on these charges — there’s no doubt he can be under state law — but, was the governor aiding and abetting him in using government resources as a private citizen and as a campaign official?”

The executive director of the state Democratic Party called the probe demand “yet another blatant attempt to politicize law enforcement from Ed Cox and his merry band of hypocrites.”

“The fact is the state GOP lacks any credible candidates, whereas Democrats have a strong slate of statewide office holders running for re-election,” Geoff Berman said.

“Cox is desperate to mask that fact with his huffing and puffing. No one is buying it.”

Vance’s office declined to comment.