The weekend got off to an especially bloody start with three people killed and more than a dozen others either shot or stabbed throughout the Big Apple, police said.

In all, nine people were shot Friday in separate incidents in Brooklyn, Manhattan and the Bronx, including three men in Brownsville; two in Bedford-Stuyvesant; two men in the northern Bronx; one in East New York and a woman in East Harlem.

One of the Bronx victims was a 35-year-old man who was fatally shot in the chest.

The violence kept up even after midnight struck, with two people murdered in separate cases in Manhattan and Queens.

Charles Reynoso was gunned down just a week shy of his 25th birthday around 5 a.m. on West 166th Street near Amsterdam Avenue, police said.

“He’s going to be 25 next Sunday,” his aunt, Annie Fernandez, 39, said through tears.

Reynoso, of Bed-Stuy, was shot in the head during a dispute with approximately five men, who then fled the scene in a black car, police said.

He was rushed to Columbia Presbyterian, but could not be saved. Police are still looking for his attackers.

About 35 minutes before Reynoso was killed, a family squabble turned fatal in Rochdale, Queens, where Terrell Coleman, 30, was stabbed in the head and torso by his 41-year-old uncle.

“I heard the noise,” recalled Edna Edwards, 94, who lives on the floor below. “I heard thumping on the floor, stomping shouting.”

Coleman, who police sources said had a history of mental illness, was pronounced dead at Jamaica Hospital Medical, police said. His uncle — identified by police sources as Eric Coleman — had not been charged as of 4:30 p.m. Saturday.

Two more people were shot and another was stabbed in Brooklyn on Saturday, according to authorities. Each victim survived.

One of those victims had an eery tale to tell.

The 49-year-old woman told cops she was inside her Putnam Avenue home around 3 a.m. when she heard a knock at the window — when she looked out, a stranger opened fire.

The victim was struck twice in the left shoulder and once in the arm, and taken to New York-Presbyterian/Brooklyn Methodist Hospital in stable condition.

“I was half asleep,” recalled a neighbor who asked to remain anonymous, but said he can see the victim’s backyard from his own window. “It’s a clear shot for sound. I heard two shots.”

“Something about summer,” he continued. “When the weather gets hotter more guns come out.”

Additional reporting by Stephanie Pagones