A Russian Soyuz capsule carrying a NASA astronaut and two Russian cosmonauts arrived at the International Space Station on Friday night, ending a nearly six-hour flight, a NASA TV broadcast showed.

U.S. astronaut Jeff Williams and cosmonauts Oleg Skripochka and Alexey Ovchinin blasted off from the Baikonur Cosmodrome in Kazakhstan at 5:26 p.m. ET and reached the station at 11:09 p.m. ET.

They replace a crew that ended a nearly year-long flight earlier this month.

The Soyuz TMA-20M spacecraft carrying the crew of Jeff Williams of the U.S., Alexey Ovchinin and Oleg Skripochka of Russia blasted off from the launchpad at the Baikonur cosmodrome, Kazakhstan, on Friday. It arrived at the International Space Station (ISS) almost six hours later. (Shamil Zhumatov/Reuters)

Williams, a grandfather and veteran of three previous spaceflights, noted that he has been in space with 45 different people over the years.

He, Skripochka, who has flown once before, and Ovchinin, a rookie, will spend about six months living and working aboard the station, a $100 billion research laboratory that flies about 400 kilometres above Earth.

.<a href="https://twitter.com/Astro_Jeff">@Astro_Jeff</a> & crew dock to Poisk module at 11:09p ET/3:09 UTC completing <a href="https://twitter.com/hashtag/Soyuz?src=hash">#Soyuz</a> trip around world 4 times in less than 6 hours. —@Space_Station

The U.S. space agency and Russia have not yet assigned crews for additional year-long missions following the March 1 return of astronaut Scott Kelly and cosmonaut Mikhail Kornienko from a 340-day spaceflight.

Williams, 58, who will be serving aboard the station for a third time, is expected to return to Earth with a career total of 534 days in space. This would surpass the current U.S. record, which is Kelly's cumulative 520 days.

The world record belongs to Russian cosmonaut Gennady Padalka, who returned from his fifth flight last September and has spent a total of 879 days in space.

"I feel very ready to be going back to the space station," Williams said in an NASA interview before the launch.

LIFTOFF! <a href="https://twitter.com/Astro_Jeff">@Astro_Jeff</a> & 2 cosmonauts launched at 5:26pm ET to the <a href="https://twitter.com/Space_Station">@Space_Station</a>. <a href="https://t.co/KX5g7zfYQe">https://t.co/KX5g7zfYQe</a> <a href="https://t.co/7zvRKLT25z">https://t.co/7zvRKLT25z</a> —@NASA

Scientists are interested in seeing how the human body fares during longer stays in space as the United States and other countries are planning for multi-year missions to Mars.

In addition to more exposure to radiation, astronauts experience bone and muscle loss and changes in their cardiovascular, immune and other systems.

Williams, Skripochka and Ovchinin join a three-man crew already aboard the station. The crew has been preparing for the arrival of an Orbital ATK cargo ship, which is scheduled to blast off from Florida on Tuesday.