Introduction Emerging work has shown erectile dysfunction (ED) to be an important indicator of cardiovascular risk via its shared pathophysiology. Yet limited research has examined if a direct relationship between ED and mortality risk exists.

Aim The purpose of this brief report was to better define the relationship between ED and mortality risk.

Methods Prevalent ED was assessed with the question: “How would you describe your ability to get and keep an erection adequate for satisfactory intercourse?” Participant data from the population‐based 2003–2004 National Health and Nutrition Examination Survey (NHANES) was linked to death certificates from the National Death Index for mortality assessment.

Main Outcome Measures Increased risk of premature all‐cause mortality among those with ED (vs. those without).

Results Of 1,790 adult men providing complete data (age range: 20–85 years; mean = 45.4 year), with 557 having ED, over a 93‐month follow‐up, 244 deceased over this time. After adjustments, those with ED (vs. those without) had a 70% increased risk of premature all‐cause mortality (hazards ratio = 1.70; 95% confidence interval; 1.01–2.85; P = 0.04).