We thank the patients who donated samples and the physician assistants, nurse practitioners, and clinicians who acquired the samples. We thank Prof. Adi Kimchi (Weizmann institute of science, Israel) for providing dual-luciferase reporter plasmids.

Author contributions

K.R.K. designed research, performed research, collected data, analyzed data and wrote the paper. S.O.S. conducted the BCL2 IRES-reporter assays and wrote and edited the manuscript. B.V. and S.V. generated the CRISPR-Cas9 Jurkat clones. T.G. and JOdB generated Ba/F3 clones containing human RPL10 WT or R98S, G.R. and S.F. performed and interpreted the 13C 6 -Glucose tracing experiment. J.V. facilitated the mice studies, and P.S. performed ATP analysis. A.U., A.V.M., C.J.H., J.P.P.M., and J.C. provided the pediatric T-ALL patient data and samples. P.V. and D.C. measured uric acid levels in serum samples. K.D.K. designed research, supervised the study and wrote the paper.

Funding

K.R.K. was supported by the Lady Tata Memorial Trust International Award for research in Leukemia. S.O.S. is recipient of an EMBO long-term postdoctoral fellowship and the EHA José Carreras Junior Research Grant. T.G. was supported by a fellowship “Emmanuel van der Schueren” from Kom op tegen Kanker. B.V. and S.V. are S.B. PhD fellow at FWO (Nos. 1S07118N and 1S49817N). GR is supported by consecutive PhD fellowships from the Emmanuel van der Schueren—Kom op tegen Kanker foundation and FWO. S.M.F. acknowledges funding support from the Concern Foundation (Conquer Cancer Now) and KU-Leuven Methusalem Co-funding. P.V. and D.C. have senior clinical investigator fellowships of the FWO Vlaanderen. This research was funded by an ERC starting grant (No. 334946), FWO funding (G084013N and 1509814N) and a Stichting Tegen Kanker grant (Grant No. 2012-176 and 2016-775) to K.D.K. and by the leukemia research grant 2017 from the “Me To You” foundation to K.R.K.