The Senate on Wednesday advanced President Trump’s nominee to lead the Environmental Protection Agency’s (EPA) Office of Air and Radiation, setting up a final vote later in the week.

The Senate voted 49-46 to end debate on William Wehrum’s nomination to be assistant administrator of the agency. If confirmed this week he will be only the second of Trump’s EPA nominees installed at the agency.

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Republicans broadly support Wehrum’s nomination, with Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellMomentum growing among Republicans for Supreme Court vote before Election Day Trump expects to nominate woman to replace Ginsburg next week Video of Lindsey Graham arguing against nominating a Supreme Court justice in an election year goes viral MORE (R-Ky.) saying he will “help undo some of the damage of the Obama administration” because Wehrum would have a host of agency regulations under his purview.

"This is an office in desperate need of new leadership from an individual who understands how to implement policies in a balanced way, rather than with extreme regulatory overreach,” he said during debate on Wednesday.

Democrats have blasted Wehrum’s nomination, noting his legal work on behalf of fossil fuel industries he would soon be regulating.

“How can we ask Mr. Wehrum to objectively administer the Clean Air Act after a career spent on one side?” said Sen. Ben Cardin Benjamin (Ben) Louis CardinPPP application window closes after coronavirus talks deadlock Congress eyes tighter restrictions on next round of small business help Senate passes extension of application deadline for PPP small-business loans MORE (D-Md.). “He has 20 years-plus working for the industry as a lobbyist.”

The Senate could vote to confirm Wehrum as soon as Thursday.