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David Silva is a major injury doubt for title favourites Manchester City’s crunch trip to Arsenal.

Silva suffered an ankle injury in City’s emphatic 3-0 derby win over local rivals Manchester United on Tuesday.

Although the Spanish midfielder played the full 90 minutes at Old Trafford, it is understood he felt pain in the ankle immediately after the game.

He has undergone intensive treatment on the problem to try to ensure he is fit for Saturday's tea-time visit to the Emirates, with the Blues’ medical staff prepared to wait until the last minute before deciding whether he can start.

The loss of Silva for clash with fourth-placed Arsenal would be a major blow to City, who are currently three points behind leaders Chelsea with two games in hand.

They will be six points adrift by kick-off if Jose Mourinho's men win at relegation-threatened Crystal Palace earlier in the day.

Silva was one of City’s stand-out performers in their emphatic win at United and is an integral part of boss Manuel Pellegrini’s plans.

City are already without their top scorer Sergio Aguero, who continues to be troubled by an ongoing hamstring problem.