Jill Biden, the wife of former Vice President Joe Biden Joe BidenThe Memo: Warning signs flash for Trump on debates Senate Republicans signal openness to working with Biden National postal mail handlers union endorses Biden MORE, said Monday it was “hard” to continue considering Sen. Lindsey Graham Lindsey Olin GrahamSenate Republicans signal openness to working with Biden Loeffler calls for hearing in wake of Netflix's 'Cuties' Quinnipiac poll shows Graham, Harrison tied in South Carolina Senate race MORE (R-S.C.) a friend amid his announcement that he intends to investigate her family.

"Well, you know, Lindsey — I don't know what happened to Lindsey. And we used to be great friends and friends with John McCain John Sidney McCainKelly's lead widens to 10 points in Arizona Senate race: poll COVID response shows a way forward on private gun sale checks Trump pulls into must-win Arizona trailing in polls MORE," Biden said on CNN’s “New Day” Monday, referring to the late senator. "I mean, we traveled together with the Foreign Relations Committee. We've had dinner, you know, and now he's changed."

Asked by CNN’s John Berman if she still considers Graham a friend, Biden responded, "You know, it's hard when you, I don't know, consider somebody a friend and then they've said so many things, so many negative things. And it's — that's been a little hurtful."

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"We used to be great friends... And now he's changed," says Jill Biden, wife of Joe Biden, about Sen. Lindsey Graham's stance on the impeachment trial. "It's hard when you consider somebody a friend and they've said so many negative things. That's been a little hurtful." pic.twitter.com/tjR1JsFrDJ — New Day (@NewDay) February 3, 2020

Graham, one of President Trump Donald John TrumpBarr criticizes DOJ in speech declaring all agency power 'is invested in the attorney general' Military leaders asked about using heat ray on protesters outside White House: report Powell warns failure to reach COVID-19 deal could 'scar and damage' economy MORE’s most vocal allies in the Senate, has continued to refer to the former vice president as a friend even as he says Hunter Biden’s business dealings in Ukraine should be investigated.

"I think this is a defining moment in the Biden campaign. Joe Biden is truly a friend. ... I think he’s a good man. But what Hunter Biden did was wrong at every level," Graham told Fox News anchor Bret Baier in October. "I think what Hunter Biden did does not pass the smell test."

Joe Biden, who has repeatedly claimed during his presidential campaign that Republican senators would be willing to work with him as president, expressed frustration about Graham in November, telling CNN’s Don Lemon Don Carlton LemonScaramucci to Lemon: Trump 'doubling down' on downplaying virus 'should scare' viewers Cohen: Trump is serious when he mentions staying for more than two terms Cohen: 'I guarantee that it's not going to go well for whoever' set up Woodward interview MORE, “I am disappointed, and quite frankly I'm angered, by the fact — he knows me; he knows my son; he knows there's nothing to this.”