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The San Francisco 49ers were outmatched during a 33-21 loss to the Arizona Cardinals in Week 5, and head coach Chip Kelly has made a change under center.

Kelly told reporters Tuesday that Colin Kaepernick will take over for Blaine Gabbert as the team's starting quarterback in Week 6 against the Buffalo Bills.

On Oct. 8, Bleacher Report's Jason Cole reported Kaepernick was expected to get the nod from Kelly after the Week 5 loss:

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Gabbert finished Week 5 at 18-of-31 passing for 162 yards, one touchdown and two interceptions. While he did add 70 rushing yards and a score on the ground in garbage time, it didn't make a difference in the outcome.

The crowd was chanting for Kaepernick to enter the game, and offensive lineman Joe Staley said, "Yeah, I'm not deaf," when asked if he heard, per Eric Branch of the San Francisco Chronicle.

Gabbert said he didn't hear the chanting, per Matt Maiocco of CSNBayArea.com: "I'm focused on leading the 11 guys on the field. When you're in the game and in a situation like that, your focus [is] on that play, that specific drive. So we're all locked in, and that's it."

Gabbert now has six interceptions in his team's last four contests, all of which were losses.

"I let this team and this organization down tonight," he said Oct. 6, per Kevin Jones of KNBR.

The former No. 10 overall pick has never appeared in a playoff game in six years for the Jacksonville Jaguars and 49ers and has failed to live up to the expectations that come with being a high pick. As a result, he'll cede the offense to Kaepernick moving forward.

While Kaepernick has generated more headlines for kneeling during the national anthem than his play this season, he is not far removed from being a Super Bowl quarterback. He directed the 49ers to the Super Bowl in the 2012 season, where they eventually lost to the Baltimore Ravens, and led them to the NFC Championship Game the next year.

He also has two seasons of more than 3,000 passing yards on his resume and will provide a rushing threat alongside running back Carlos Hyde in Kelly's read-option looks.

Kaepernick has a more established track record than Gabbert and will garner additional looks from Kelly as the 49ers attempt to turn around their lackluster start.