LOS ANGELES — “Crazy Rich Asians,” powered by jubilant reviews and pent-up demand for a major Hollywood film led by Asian stars, took in a strong $25.2 million at North American theaters over the weekend, easily enough for No. 1.

It was the best result for a PG-13 romantic comedy in six years — since “Think Like a Man,” which featured an all-black primary cast and collected $33 million over its first three days. Among all nonsequel comedies, “Crazy Rich Asians” (Warner Bros.) posted the biggest turnout since the R-rated “Girls Trip,” which was released last summer and focused on four black women, a rarity.

“This shows — once again, with emphasis — that true diversity matters,” Brad Simpson, a “Crazy Rich Asians” producer, wrote in an email on Sunday. “Audiences are tired of seeing the same stories with the same characters. And we have to give people a reason to get off their couch or devices. We have to give them something different.”