The MTV scripted drama will return with a brand-new cast, location and producing team as the franchise will focus on a less white story.

MTV is trying its hand again at a Scream reboot.

The Viacom-owned cable network, which recently saw Chris McCarthy tapped to lead the network, is officially retooling the third season of the film-to-TV reboot. The previously announced six-episode third season will feature a brand-new cast, new location and a largely new creative team as the story is poised to become less white.

Behind the scenes, Brett Matthews (The Vampire Diaries, Supernatural) has been tapped as Scream's latest showrunner. (his first time serving as showrunner.) Additionally, Queen Latifah, Shakim Compere and Yaneley Arty will join the series as executive producers via Latifah's Flavor Unit Entertainment banner. Harvey and Bob Weinstein will remain on board as exec producers via Dimension TV, as will Wes Craven, Tony DiSanto, Liz Gateley, Marianne Maddalena and Cathy Conrad. Matthew Singer and Keith Levine produce.

Jill Blotevogal and Jaime Paglia steered the series in season one, with Blotevogel reworking the script from Jay Beattie and Dan Dworkin. Michael Gans and Richard Register served as showrunners on season two. It is unclear whether the series will morph into an anthology, after speculation at the start of seasons one and two.

The series will feature an entirely new cast — which insiders say will be more inclusive as the series looks to put a new spin on a proved concept that has not been embraced on the small screen. Season two of Scream averaged only 377,000 total viewers — with seven days of DVR. A premiere date for Scream and its new cast will be announced at a later date. None of the original stars — including John Karna, Carlson Young, Bex Taylor-Klaus and Amadeus Serafini — are returning. Meanwhile, former Scream leading lady Willa Fitzgerald has already moved on with a key role in Fox's Behind Enemy Lines pilot.

Matthews, who served as Joss Whedon's assistant on Buffy the Vampire Slayer and Angel, is repped by WME, Management 360 and Jackoway Tyerman.