Ingestion of ethylene glycol may be an importan oisoning. t contributor in patients with metabolic acidosis of unknown cause and subsequent renal failure. Expeditious diagnosis and treatment will limit metabolic toxicity and decrease morbidity and mortality. Ethylene glycol poisoning should be suspected in an intoxicated patient with anion gap acidosis, hypocalcemia, urinary crystals, and nontoxic blood alcohol concentration. Fomepizole is a newer agent with a specific indication for the treatment of ethylene glycol poisoning. Metabolic acidosis is resolved within three hours of initiating therapy. Initiation of fomepizole therapy before the serum creatinine concentration rises can minimize renal impairment. Compared with nervous system and hypoglycemia, and easier maintenance of effective plasma levels.

Family physicians are often the first health care professionals to see patients with undifferentiated complaints, including patients who have acute ingestion of poison. The American Association of Poison Control Centers reported more than 4,800 and 6,000 exposures to ethylene glycol in 19971 and 1998,2 respectively. Although the majority of these cases were unintentional, 21 in 1997 and 22 in 1998 were fatal. These reports are based on a surveillance system that underestimates the actual number of exposures.

Ethylene glycol is a solvent found in products ranging from antifreeze fluid and de-icing solutions to carpet and fabric cleaners.3,4 According to results from animal studies,4 the ingested amount of ethylene glycol required to produce toxicity in animals is approximately 1.0 to 1.5 mLper kg, or 100 mL in an adult. When treated appropriately, patients have survived much larger ingestions.4 Ethylene glycol is an important cause of metabolic acidosis of unknown source and subsequent acute renal failure. While death and renal failure may occur with delayed diagnosis, death is uncommon in persons who receive prompt diagnosis and treatment.

Pathophysiology Jump to section + Abstract

Pathophysiology

Clinical Manifestations

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References Toxicity results from the depressant effects of ethylene glycol on the central nervous system(CNS). Metabolic acidosis and renal failure are caused by the conversion of ethylene glycol to noxious metabolites. Oxidative reactions convert ethylene glycol to glycoaldehyde, and then to glycolic acid, which is the major cause of metabolic acidosis.5–7 Both of these steps promote the production of lactate from pyruvate.4,8 The conversion of glycolic acid to glyoxylic acid proceeds slowly, further increasing the serum concentration of glycolic acid.4 Glyoxylic acid is eventually converted to oxalic acid and glycine. Oxalic acid does not contribute to the metabolic acidosis, but it is deposited as calcium oxalate crystals in many tissues.4 Ethylene glycol is rapidly absorbed by the stomach and small intestine, and is quickly redistributed throughout the body. Metabolites of ethylene glycol remain in thebodyfor several days, with calcium oxalate present in tissues for much longer.3 The clinical syndrome of ethylene glycol intoxication has traditionally been divided into three stages: progressive involvement of the CNS, the cardiopulmonary systems, and the kidneys. However, presentation is highly variable and dependent on the amount ingested, the combined ingestion with ethanol, and the timing of medical intervention.4

Clinical Manifestations Jump to section + Abstract

Pathophysiology

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References Ethylene glycol produces CNS depression similar to that of ethanol. Symptoms of ethylene glycol toxicity include confusion, ataxia, hallucinations, slurred speech, and comaSymptoms are most severe six to 12 hoursafter ingestion, when the acidic metabolites ofethylene glycol are at their maximal concentrationThe presentation may be similar toethanol intoxication, if the patient presentsearly or has consumed small amounts of ethyleneglycol. However, an ethanol odor will beabsent, and serum or respiratory ethanol levelswill be too low to account for the degree ofCNS depression. The absence of a strong odorof alcohol in a patient who appears intoxicatedshould raise the suspicion of ethyleneglycol ingestion.4 Following a period of CNS depressionmetabolic acidosis and cardiopulmonary symptoms become prominent, although co-ingestion of ethanol will delay the metabolic acidosis. The patient may experience nausea, vomiting, hyper ventilation, and hypocalcemia with muscle tetany and seizures. Hypertension, tachycardia, and cardiac failure may ensue. Pneumonitis, pulmonary edema, and adult respiratory distress syndrome have also been reported.3,9 Renal involvement may become apparent within 24 to 72 hours after ingestion. Urinary crystal formation requires a sufficient amount of time for ethylene glycol to be metabolized into oxalate. Calcium oxalate formation depletes serum calcium levels and deposits in intestinal mucosa, liver, brain, heart, lung, and kidney. The excretion of calcium oxalate crystals in the urine is usually, but not always, present. Oliguric or anuric renal failure is the result in the most severe cases and, although permanent renal failure is rare, recovery of renal function may take up to two months.3,5,9 If untreated, severe ethylene glycol toxicity is usually fatal within 24 to 36 hours.3,5–8,10

Illustrative Case Jump to section + Abstract

Pathophysiology

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References A 19-year-old man who presented to the emergency department was completely unresponsive. His coworkers noted that he had a decreased level of function and had stumbled and fallen several times at work. The patient eventually became alert enough to admit that he had ingested three gallons of antifreeze within the past 48 hours. Physical examination while the patient wasminimally alert but disoriented revealed a rectal temperature of 37.8°C (100.1°F); pulse, 116 beats per minute; respiration, 28 per minute; blood pressure, 152/80 mm Hg; and pulseoximetry, 98 to 99 percent saturation on roomair. Neurologic examination was normal, lungs were clear to auscultation, and his extremities showed no cyanosis or edema. The patient's blood chemistry data at admissionare shown in Table 1. Microscopic examination of the urine revealed more than 200 redblood cells per high-power field, trace bacteria, and unidentifiable crystals. A urine toxicologyscreen was negative. A serum ethyleneglycol level of 104 mg per dL (15.6 mmol perL) was reported from an outside laboratory approximately six and one-half hours after the blood sample was obtained. View/Print Table TABLE 1 Admission Laboratory Data for Illustrative Case Component Value Reference range traditional units Sodium 141 mEq per L (141 mmol per L) 135 to 145 Potassium 3.6 mEq per L (3.6 mmol per L) 3.5 to 5.3 Chloride 106 mEq per L (106 mmol per L) 98 to 108 Glucose 103 mg per dL (5.7 mmol per L) 70 to 110 CO 2 content 6 mEq per L (6 mmol per L) 20 to 30 Anion gap 33 mEq per L (33 mmol per L) 6 to 17 BUN 8 mg per dL (2.85 mmol per L) 7 to 20 Creatinine 2 mg per dL (180 μmol per L) 0.7 to 1.3 Calcium 10.8 mg per dL (2.70 μmol per L) 8.5 to 10.4 Creatine kinase 305 U per L 35 to 230 Myoglobin 398 ng per mL 0 to 110 Osmolality 314 mOsm per kg of water 278 to 305 Arterial pH 7.30 7.35 to 7.45 Paco 2 13 mm Hg 34 to 38 Pao 2 136 mm Hg 65 to 75 Bicarbonate 6.21 mEq per L (6 mmol per L) 21 to 28 Blood alcohol < 10 mg per dL Salicylate < 5.0 mg per dL (0.35 mmol per L) 15 to 30 TABLE 1 Admission Laboratory Data for Illustrative Case Component Value Reference range traditional units Sodium 141 mEq per L (141 mmol per L) 135 to 145 Potassium 3.6 mEq per L (3.6 mmol per L) 3.5 to 5.3 Chloride 106 mEq per L (106 mmol per L) 98 to 108 Glucose 103 mg per dL (5.7 mmol per L) 70 to 110 CO 2 content 6 mEq per L (6 mmol per L) 20 to 30 Anion gap 33 mEq per L (33 mmol per L) 6 to 17 BUN 8 mg per dL (2.85 mmol per L) 7 to 20 Creatinine 2 mg per dL (180 μmol per L) 0.7 to 1.3 Calcium 10.8 mg per dL (2.70 μmol per L) 8.5 to 10.4 Creatine kinase 305 U per L 35 to 230 Myoglobin 398 ng per mL 0 to 110 Osmolality 314 mOsm per kg of water 278 to 305 Arterial pH 7.30 7.35 to 7.45 Paco 2 13 mm Hg 34 to 38 Pao 2 136 mm Hg 65 to 75 Bicarbonate 6.21 mEq per L (6 mmol per L) 21 to 28 Blood alcohol < 10 mg per dL Salicylate < 5.0 mg per dL (0.35 mmol per L) 15 to 30

Diagnosis Jump to section + Abstract

Pathophysiology

Clinical Manifestations

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Diagnosis

Treatment

References Little correlation exists between blood levels of ethylene glycol and severity of poisoning,4 making the diagnosis unclear at times. Therefore, clinical or laboratory evidence is an indication for treatment even if toxic levels are not demonstrated.3,4,6,9 Indicators for a quick diagnosis of ethylene glycol poisoning include hyperventilation with laboratory data suggestive of an elevated anion gap metabolic acidosis; an osmolar gap; the presence of hypocalcemia; and urinary crystals.4,6,8,9 Ethylene glycol or glycolic acid concentrations are definitive but may not be available9; in this situation, urine microscopy to identify the presence of crystals should follow determination of the anion or osmolar gaps.4,6 Calculation of the anion and osmolar gaps can facilitate an early diagnosis, and should be performed when the origin of metabolic acidosis is unknown. An increased anion gap with a normal chloride concentration indicates retention of nonvolatile organic acids such as glycolic acid.5–7,9 The osmolar gap (O g ) is calculated by subtracting the calculated serum osmolality (O c ) from measured osmolality (O m ), or O g = O m − O c (Table 2). If the serum osmolar gap is greater than 10 mOsm per kg of water, the presence of ethylene glycol poisoning is likely.5,9 Some recent reports6,11 suggest that a normal osmolar gap is -10 to +20 mOsm per kg of water, but current recommendations use an osmolar gap greater than 10 for initiating treatment with an antidote.4 While elevated serum osmolality combined with an elevated anion gap strongly suggests ethylene glycol poisoning, the absence of either does not rule out a significant ingestion. If the patient presents soon after ingestion, ethylene glycol may not yet have been converted to its acid metabolites; late presentation may reveal no osmolar gap because the ethylene glycol has already been converted to toxic, but osmotically inactive, products. High serum ethanol concentrations will cause an overestimation of the osmolar gap.9 View/Print Table TABLE 2 Calculation of Osmolar Gap TABLE 2 Calculation of Osmolar Gap The serum ethylene glycol test is specific for poisoning but is not commonly available. It requires a separate, dedicated gas chromatography column. This test is expensive (approximately $90, excluding transportation and handling fees). Although the test is not a good indicator of prognosis, a documented level above 20 mg per dL (3 mmol per L) is an indication for treatment with fomepizole (Antizol).4 The excretion of calcium oxalate crystals in the urine is a finding in approximately one half of patients and may be accompanied by red blood cells and myoglobin casts.5,9 Calciuma oxalate crystals appear in many forms, the most common being needle-shaped monohydrate. Unfortunately, the needle-shaped forms areoften confused with hippurate. The dihydrate, envelope-shaped form is only present at high concentrations of calcium and oxalate, and willtransform to the monohydrate. Crystalluriamay develop after admission, and an initialnegative microscopic result should, therefore, be repeated.3,6,12 Examination of the urineusing a Wood's lamp may be helpful, because antifreeze products contain fluorescein.