Sen.(R-S.C.) warned on Tuesday that’s nomination to the Federal Reserve Board would be “very problematic,” marking the latest warning shot from Republicans on Capitol Hill.

“It will be a very problematic nomination,” Graham, a top Senate ally of President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE's, told reporters.

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Asked if he would not support Moore, Graham said that he was still reviewing him.

Separately, GOP Sen. Joni Ernst Joni Kay ErnstThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Liberal super PAC launches ads targeting vulnerable GOP senators over SCOTUS fight Romney backs pre-election Supreme Court vote, paving way for McConnell, Trump MORE (Iowa) said it was "very unlikely" that she would support his nomination.

The remarks from Graham and Ernst underline the trouble Moore’s possible nomination would face if Trump formally sends it to the Senate.

A number of senators have expressed disgust or opposition to Moore's past writings about women. In one column written for National Review in 2002, Moore wrote that women should have no role in men's college sports unless they dress in halter tops.

Several female senators have voiced concerns, and Sen. John Thune John Randolph ThuneOvernight Defense: Stopgap spending measure awaits Senate vote | Trump nominates former Nunes aide for intelligence community watchdog | Trump extends ban on racial discrimination training to contractors, military Remote work poses state tax challenges Senate GOP sees early Supreme Court vote as political booster shot MORE (S.D.), the No. 2 Senate Republican, warned that reservations about Moore likely spread beyond just female senators.

Trump has not actually nominated Moore to the Federal Reserve board. The White House is sticking behind him publicly, even as he’s faced growing questions among Republicans.

"We're still behind him," National Economic Council Director Larry Kudlow Larry KudlowMORE told reporters at the White House, adding that Moore is still going through "the process of vetting" and there has been "no change" in Trump's position.

Republicans have 53 seats in the Senate, meaning they could lose three Republicans and still confirm Moore if Vice President Pence broke a tie.

Sylvan Lane contributed.