MSNBC's Mika Brzezinski invoked the 25th Amendment on Wednesday in making the argument that President Trump Donald John TrumpSteele Dossier sub-source was subject of FBI counterintelligence probe Pelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Trump 'no longer angry' at Romney because of Supreme Court stance MORE should be removed from office, declaring he "is not fit to lead" while arguing he "might do something crazy in five minutes, one hour, tonight or tomorrow."

"On the foreign policy front, he is cratering our reputation. He is making us an international joke," said Brzezinski, a staunch Trump critic and the daughter of the late Zbigniew Brzezinski, who served as former President Carter's national security adviser, on "Morning Joe."

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Mika Brzezinski's perspective came during a discussion around the president calling adult-film star Stormy Daniels "horseface" after a federal judge ordered she was liable for Trump's legal fees upon dismissing a defamation suit she brought against the president.

"We are losing our influence because this is the type of man who calls a woman a 'horseface.' By the way, a woman he chose to have sex with," she continued. "I don’t know where that begins and ends and I wouldn’t want to pick that apart."

"But if you look at how he is speaking on the international stage about the murder of a Washington Post reporter [Jamal Khashoggi], that itself should be deeply disturbing to anybody who works inside the White House, works on the national security team, works in the State Department," she added. "At some point, you are working for a president who is not fit to lead, who is going to do something crazy in five minutes, one hour, tonight or tomorrow."

"What more do you need to hear from him to start thinking 25th Amendment or something else?"

The president said earlier this week that “rogue killers” could have killed Khashoggi, 60. He also stated Tuesday in an interview with The Associated Press that declaring the Saudi Arabian government as guilty for Khashoggi’s disappearance was another example of “guilty until proven innocent,” referring to allegations of sexual misconduct leveled against Supreme Court Justice Brett Kavanaugh Brett Michael KavanaughTrump faces tricky choice on Supreme Court pick The Hill's 12:30 Report: Trump stokes fears over November election outcome The Hill's Morning Report - Sponsored by Facebook - Trump previews SCOTUS nominee as 'totally brilliant' MORE before his confirmation.

Khashoggi was seen entering the Saudi consulate in Istanbul, Turkey on Oct. 2 but was never seen leaving the building. Turkish officials believe he was tortured and murdered.

Brzezinski, along with co-host Joe Scarborough, have claimed the president is "mentally ill" and is suffering from "early on-set dementia" on multiple occasions on the MSNBC morning show.