A recent study contributes to the literature suggesting a bidrectional relationship between schizophrenia and autoimmune diseases. In a Danish cohort, individuals with schizophrenia and infectious exposures (hospitalization), the incidence of autoimmune disease was almost 3x as frequent.

Schizophrenia likely shares underlying pathology with autoimmune disorders in the form of acute on chronic inflammation, and dysfunctional immune response.

In addition to infection, to which patients are more susceptible in the setting of nutrient-poor diets and stress, there are other important factors that contribute to inflammation and a reactive immune system. These include vaccines, food antigens, and environmental toxins such as metals, plastics, and flame retardants.

If we consider schizophrenia to be a manifestation of disordered immunity, we might look to lifestyle factors such as stress, exercise, diet, and a clean environment as first line treatments.

Read the abstract of this study suggesting a relationship between schizophrenia and autoimmune disease.