Now matter how vocal Josh Garnett becomes as an emerging leader of the Stanford offense, he won’t be the best talker in his family.

That would be his twin sister, Rachel, the captain of the highly respected debating team at Wiley College in Marshall, Texas. The team was featured in the 2007 movie “The Great Debaters,’’ starring Denzel Washington.

“She wants to get into broadcasting,” Garnett said. “She’d be great at that. I definitely don’t argue with her. She’s a great talker. She’s really good at her craft. She could take over the world if she wanted to. I tell her that all the time.”

He has lofty ambitions too. Besides a third straight Rose Bowl and eventually an NFL career, the junior guard would like to become an emergency-room doctor. He’d be quite a presence in an ER — a 6-foot-5, 325-pound guy with an engaging smile.

“He’s the life of the party,’’ Stanford offensive coordinator and offensive line coach Mike Bloomgren said. “He’s got that big, booming voice.”

On the other hand, Bloomgren jokes about the idea of Garnett performing surgery. “He’s got hands like a bear,” he said. “I tell him all the time, I’m never going to let him cut on me. Those are some big mitts.”

Those mitts will be full on Saturday when the No. 16 Cardinal (2-1, 0-1 Pac-12) visit Washington (4-0, 0-0) at Husky Stadium. It’s the second time Garnett has played back in his home area. He was one of the most highly rated offensive linemen in the nation when he came out of Puyallup High, where he reportedly executed 70 pancake blocks as a senior.

Against the Huskies, he’ll be one of the people trying to keep nose tackle Danny Shelton at bay. Shelton leads the nation with seven sacks, an extraordinary number for a nose tackle.

While growing up, Garnett attended a lot of UW games with his father, Scott, who was a nose tackle for the Huskies in the early 1980s before playing four years in the NFL with four teams, including the 49ers.

Washington tried hard to recruit the son, but in the end he picked Stanford over Michigan. Some UW fans reacted angrily. According to the Seattle Times, one tweeted, “And thus, everyone in the state of Washington proceeds to forget about Mr. Joshua Garnett.” Other tweets were more hostile.

“It’s just great fans being great fans,” Garnett said. “You’ve got to expect that.” When Stanford played UW two years ago at the Seahawks’ CenturyLink Field (while Husky Stadium was being renovated), it was a sad homecoming for Garnett. The Cardinal were upset 17-13.

“That was probably the loudest stadium that I’ve played in,” he said.

He doesn’t think the noise will bother the offense this time. And going back to his home area isn’t as big a deal anymore, he said.

“Now it’s just a business trip,” he said. “It’s our first Pac-12 North opponents, so it’s important to me. That’s way more important than going home.”

Tom FitzGerald is a San Francisco Chronicle staff writer. E-mail: tfitzgerald@sfchronicle.com Twitter: @tomgfitzgerald