Harry and Lloyd returned to theaters after a 20-year absence Thursday night, with Universal’s comedy sequel “Dumb and Dumber To” taking in a respectable $1.6 million at 2,321 locations in the U.S.

The initial number indicates that the film, which sees Jim Carrey and Jeff Daniels reprising their farcical characters, can challenge powerful holdovers “Big Hero 6” and “Interstellar” for the top slot this weekend. Forecasters have predicted “Dumb and Dumber To” will take in $30 million-plus from 3,152 locations.

The sequel carries a $40 million price tag, and is backed by Red Granite Pictures with “Dumb and Dumber” directors Peter and Bobby Farrelly returning to the helm. Universal has been actively promoting the film and its visual gags in recent months in all media.

The original “Dumb and Dumber” grossed $127 million domestically for New Line in 1994.

Disney’s second weekend of “Big Hero 6″ could recapture the top slot with estimates putting the pic around the $30 million mark. The toon opened with $56.2 million last weekend and had added $18 million by Wednesday.

Christopher Nolan’s sci-fi epic “Interstellar” is expected to wind up in third in the $25 million range for Paramount, after opening with $47.5 million over the weekend.

“Interstellar” took in $3.5 million in Thursday night preview showings, while “Big Hero 6” managed $1.4 million at those shows.

Relativity’s romancer “Beyond the Lights” is the weekend’s other wide opener with forecasts for a modest debut in the $8 million to $10 million range at 1,789 locations.