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Ben Margot

Kickoff Time: 4:25 p.m. ET

Network: Fox

The 49ers handed it to the Cardinals twice last season. They beat them in front of their home crowd early on in the season and kept them out of the playoffs in Week 17. San Francisco would like to think it has the upper hand in 2014, but beating Bruce Arians' club twice will be easier said than done.

The Cardinals got better on both sides of the ball and will have key players return on the offensive line. This could prove to hurt the 49ers in Arizona, but not in San Francisco. The Niners are one of the best home teams in the NFL, and the Cardinals struggled on the road last season.

This year's game in San Francisco will be closer than it was last year, but the outcome will be the same. Frank Gore will wear Arizona's front seven down, and Colin Kaepernick will deliver a kill shot to Anquan Boldin late in the game to seal the Cardinals' fate.

Prediction: Win

Final Record: 10-6