A unattended piece of luggage in Melbourne that triggered alarm from the bomb squad has been cleared as non-suspicious.

On Tuesday morning bomb squad officers created an exclusion zone at the corner of Harbour Esplanade and La Trobe Street in Docklands, forcing the evacuation of several businesses, including the Seven Network.

The bomb squad use a remote-controlled device to inspect the abandoned piece of luggage. Credit:Jason South

A police spokeswoman said the suitcase was found about 9.30am and police were conducting a "safety check".

About 12.30pm, the spokeswoman said the luggage was deemed non-suspicious and the bomb squad was clearing the scene.

A specialist bomb squad officer takes no chances outside the Channel Seven building. Credit:Jason South

The roads have been reopened. Traffic diversions had been in place earlier.

She said the area had been cordoned off earlier as a precaution.