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A crucial analysis of the House GOP health care bill is expected this week from the Congressional Budget Office — and its projections of how many Americans would gain or lose insurance under the plan and the impact on the deficit will immediately become a major part of the debate.

The CBO is a nonpartisan government agency that looks at the effects of proposed legislation and keeps lawmakers updated with budget projections and economic forecasts. House Democratic aides expect the CBO’s results to arrive as early as Monday.

If early analyses from outside groups are to be believed, the numbers could be grim. That’s a problem for the Trump administration, which continued to raise expectations on the House bill through the weekend.

Health and Human Services Secretary Tom Price said on "Meet The Press" on Sunday that “nobody will be worse off financially” under the American Health Care Act, as the House bill is called, and that "we'll have more individuals covered” — two claims that experts across the ideological spectrum say are highly unlikely to prove accurate.

Key members of the Trump administration and allies on Capitol Hill are already pre-spinning the CBO report, arguing the agency's previous analyses, or scores, on health care have been inaccurate and that the bill is only one part of a process that will include executive actions and future legislation.

White House chief economic adviser Gary Cohn called the CBO’s analysis “meaningless” on "Fox News Sunday."

“If you’re looking to the CBO for accuracy, you’re looking in the wrong place,” White House Press Secretary Sean Spicer told reporters last week.

The CBO’s projections on President Barack Obama's Affordable Care Act were mixed, but a 2015 study by the Commonwealth Fund found they were the closest to the mark among major nonpartisan analysts.

Robert Reischauer, who directed the CBO from 1989 to 1995, told NBC News that some criticism of the agency’s past projections were valid.

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But, he said, CBO still has “the greatest capability of any entity to make these kinds of estimates,” thanks to its experience, official role and transparent methodology.

“Would I bet my dog’s life on [the CBO score]? No,” Reischauer said. “But do I think it’s a very solid estimate? Yes, if I had to make policy.”

Related: Trump voters would be hardest hit by GOP health care proposal

The report comes even as a number of moderate and conservative lawmakers have expressed skepticism the bill would lower premiums and improve coverage and it's unlikely a poor score would boost their confidence.

"I believe [the AHCA] would have adverse consequences for millions of Americans and it wouldn't deliver on our promises to reduce the cost of health insurance for Americans," Sen. Tom Cotton (R-AR), often an ally of the Trump administration, told ABC's "This Week" on Sunday.

The White House has previously accused holdovers from the Obama administration of undermining its agenda, but that argument won’t hold with the CBO, whose current director, Keith Hall, was selected by Republican Congressional leaders in 2015 and previously served as an economist for President George W. Bush.

As chair of the House Budget Committee, Price lavished praise on Hall and emphasized the agency’s value in crafting legislation.

“[Hall's] vast understanding of economic and labor market policy will be invaluable to the work of CBO and the important (role) it will continue to play as Congress seeks to enact policies that support a healthy and growing economy,” he said in a statement after Hall's appointment to CBO.

But Price sang a less upbeat tune Friday when he was pressed on MSNBC’s "Morning Joe" about Hall’s role in the process, saying the CBO had a record of “woefully underperforming when it comes to evaluating health systems.”

While the CBO will be the most significant analyst, outside experts on the left, right and center are already highlighting several provisions in the House plan that are likely to cause people to lose coverage.

The bill would eliminate an expansion of Medicaid that covered over 11 million people while reducing tax credits to buy insurance for many low-income Americans. Some of these cuts could be offset by a temporary fund that would provide grants to states to shore up their insurance markets, but analysts are so far skeptical they’ll make up the difference.

Related: GOP wants more health care choices. Is that good?

Brookings scholars Matthew Fiedler and Loren Adler estimated at least 15 million people would lose insurance coverage under the plan. S&P Global Ratings estimated coverage loses of 6 to 10 million people.

Disagreeing with the CBO when it detracts from your arguments and highlighting its findings when it validates them is hardly new.

As critics quickly pointed out, Spicer himself cited CBO scores that corroborated attacks on Obamacare before he joined the White House. Democrats have been known to argue with the CBO as well: Obama’s White House challenged the agency’s 2014 assessment that an increase in the minimum wage would reduce jobs.

The current fight is notable, however, because it’s occurring before the score has been made public and because Trump has repeatedly attacked the legitimacy of government data, intelligence reports and even federal judges, while at times citing fringe sources to back up claims.

Still, some of the current hand wringing over the impending score feels familiar. Reischauer ran the agency during President Bill Clinton’s unsuccessful push for health care reform, when his analyses served as a wet blanket for Democratic lawmakers struggling to find a workable compromise that could provide affordable care without blowing up the deficit.

“That debate was as highly charged as this one,” he said. “I look at this and see it playing out very much the same way.”