The Victorian Liberal Party will preference the Greens last in the November 29 election, behind Labor and the far-right Rise Up Australia Party, Premier Denis Napthine has said.

The party's similar move in the 2010 election was described as strategically clever.

Dr Napthine said the Greens would threaten Victoria's economy.

"The Greens simply don't understand that a strong economy is the key to a better Victoria for all Victorian families," he said.

"The Greens are vehemently opposed to major infrastructure projects like the East West Link.

"The Greens will threaten the future of our strong economy. They will destroy jobs and put Victorian families at risk."

But Dr Napthine caused confusion by saying the Greens would be last on the Liberals' preference list in all Lower and Upper House seats, but the party would also consider putting extremist parties below them.

"We reserve the right, if there's an extremist candidate who is perhaps a racist candidate, that they would not be above the Greens," he said.

The leader of Rise Up Australia, Danny Nalliah, is well-known for his strident anti-Islamic views.

He railed against multiculturalism and described Islam as a "death cult" at his party's campaign launch.

Last week, State Opposition leader Daniel Andrews moved to distance himself from the Greens by rejecting a formal offer for a statewide preference deal.

Labor also ruled out any power-sharing arrangement with the minor party in the event of a minority government.

But Dr Napthine said there was still some uncertainty about the relationship between Labor and the Greens.

"It's now crunch time for Daniel Andrews and Labor," he said.

"I call on Daniel Andrews and Labor to join the Liberals in putting the Greens last on their how-to-vote card.

"If Daniel Andrews and Labor fail this simple test of putting the Greens last on their how-to-vote cards, then all Victorians will know that if they vote for Labor they're voting for a Labor-Greens alliance."

The Liberals' decision to preference the Greens last in the 2010 election helped Labor hold onto a clutch of inner-city seats that had been under threat from the Greens.

Greens leader Greg Barber said many inner-city Liberal voters would preference his party anyway.

"We know from experience that 60 per cent of Liberals in the inner-city ignore the how-to-vote card and many of them will preference Green anyway, because they're just desperate to get some action on climate change," he said.

"In the same way that Adam Bandt [Federal MP for Melbourne] got re-elected, against what the Liberals told their vote to do, we think we've got a very good chance in the inner-city."

Mr Barber said the Greens still hoped to take seats off the Liberals at the election.