Starting from 5.0.16 theres been graphics artifacts which hang the desktop (Gnome 3) on a Ubuntu 14.04 guest with the latest Xenial LTS kernel (4.4) and guest additions installed on a Windows 7 64bit host.

The graphics artifacts effectively start after you open Chome and even restarting Gnome 3 doesnt resolve the artifacts. This partially happened in 5.0.14 but only for a few seconds when you initially open Chrome and then it goes away and is usable. From 5.0.16/20 this pretty much makes the GUI desktop unusable once you open Chrome.