The vampyric blood essence is one of the blood essences players can craft after the quest River of Blood. Using Haemalchemy, players can combine 100 congealed blood with a 4-dose Super Zamorak brew potion. Unlike other blood essences, this does not require a various amount of vyre corpses to be cremated in the Columbarium in order to be made. When received as a one-time gift from Vanescula Drakan after the quest or created manually, it will have 1,000 charges. Additional charges can be added by using more congealed blood on the essence, giving 10 charges each, to a maximum of 5,000 charges. If charges are completely exhausted, the essence's effects no longer function, but it can still be worn.

When worn, it has a passive effect that has a chance of healing 2.5% of melee damage dealt, to a maximum of 250. When activated, the next melee hit within 20 seconds heals for 25% of damage dealt, to a maximum of 2,500.

The active effect can be used once per minute. This cooldown is shared with other blood essences, except the tireless essence. Each passive effect consumes 1 charge and each active effect consumes 50 charges. Both effects will still consume on the next hit even at full health.

Having a blood essence equipped and attempting to enter the Mausoleum notifies the player "You have a blood essence equipped which makes the ravenous ghouls aggressive. Are you sure you wish to proceed?"

According to the book Haemalchemy (Vol. 2), this blood essence is described as:

Modify your red blood cells to imbibe the oxygen, haemoglobin and energy from the wounds of organisms that you strike in melee.