Indianapolis Colts @ Tennessee Titans

How the Titans Win …

I’m looking very forward to this one as a Titans fan. For years and years it was Peyton Manning and Andrew luck that had their way. Andrew Luck and the Colts never lost to the Titans in 11-games against their divisional foe.

The Titan’s D went ballistic against the Browns last week racking up five sacks and three interceptions. Cameron Wake joined the 100-sack club with a safety and 2.5 sacks while Butler’s pick-6 took the Titan D’s tally to 8 points for the day. The key for the D will be in the secondary, with T.Y. Hilton vs Adoreé Jackson a crucial matchup.

Mari-GOAT-a and the Titans will be looking to exploit the Colt’s secondary which struggled against Keenan Allen and the Chargers. Rookie wideout A.J. Brown exploded in his first game but Corey Davis or Adam Humphries could breakout in this one. Mariota can also rely on his trusty tight end Delanie Walker down the middle.

A win for the Titans would be their first 2-0 start since 2008. Tennessee is 16-4 in their last 20 at home and the retirement of former quarterback Steve McNair and running back Eddie George’s numbers should be enough motivation for the wub against an old nemesis.

The Titan’s Cameron Wake was named AFC Defensive Player of the Week. The Titans will be relieved that he’s on their side this week. Wesley Hitt/Getty Images

How the Colts Win …

For the Colts last week Adam Vinatieri’s wayward kicking was the difference in a 6-point loss to the Chargers, missing an extra-point conversion, a 29 and 46 yard field goals. Jacoby Brissett will need to try and navigate through an extremely stingy Titan’s defence.

The overtime road loss against the Chargers will hurt but nothing would make them feel happier than a road win against the Titans. Although the Colts are Luckless, Brissett will have one of the best offensive lines in the NFL looking to give him as much time in the pocket.

A key matchup will be offensive tackles Anthony Castonzo and Braden Smith up against the explosive pass rushing duo of Cameron Wake and Harold Landry. The O-line will also need to create some space to establish Marlon Mack’s running game, who went for 203 yards including a 63-yard touchdown last week.

The Colts hold an overall record of 33-15 (0-1 in playoffs) and have won the last 13 of 15 against the Titans

Jacksonville Jaguars @ Houston Texans

How the Texans Win …

The Texans should be extra motivated following a heartbreaking loss to the Saints on a 58-yard field goal as time expired. J.J. Watt failed to record a sack, quarterback hit or tackle for the first time in his career. Perhaps the loss of Jadeveon Clowney is impacting Watt more than we thought it would.

More worryingly for the Texans is the mess of their offensive line which conceded six sacks against New Orleans. On a good note the Jags recorded zero sacks last week. How Deshaun Watson still managed a QB rating of 114.3 and 3 touchdowns shows just how special he is.

Watson and DeAndre Hopkins connected on 8 of 11 passes for 111 years and 2 touchdowns last week and if they can throw up similar numbers, well the Jags are in for a long day. The last time these two met Hopkins reeled in a career high 12 catches and 147 yards so expect Hopkins to be targeted.

J.J. Watt should fire up in this one after his first career shutout. The Houston defense against a rookie quarterback in his first NFL start may just be the difference in this one. Laremy Tunsil and the Houston O-line will need to put it together to ensure that Watson isn’t running for his life however.

Watson and Hopkins are have developed a rapport built on friendship and chemistry.

How the Jags Win …

Jacksonville have issues, still reeling from the loss of their franchise quarterback Nick Foles after breaking his collarbone in the 1st-quarter last week. His replacement, sixth-round draft pick Gardner Minshew will be out to prove in his first NFL start that his 22 of 25 pass completions, 275 throwing yards and two touchdowns was not a case of beginners luck.

Leonard Fournette who lined up in 86% of snaps last week will be the offensive centrepiece for the Jags with Foles out for a lengthy period. The Chiefs held Fournette to 66 yards on the ground but the Jags were launching an aerial raid to try and keep up. The key for the Jags will be to lean on their explosive ground game with Minshew throwing some ball Fournette’s way.

On the other side of the ball Jacksonville’s secondary will need to be on lockdown and key to this is the Jalen Ramsey vs. Deandre Hopkins matchup. If Ramsey can utilise his physicality, length, and athleticism against Hopkins it might just be enough to turn a QB pressure into a sack against a leaky Houston O-line and swing this one Jacksonville’s way.