ORCHARD PARK, New York – Buffalo Bills defensive end Jerry Hughes said he didn't pay much attention to Johnny Manziel's prolific college career, but Hughes was alert Sunday when Manziel replaced Brian Hoyer as the Browns quarterback.

"Absolutely,'' said Hughes, a Texas Christian product. "We know he's more of a dynamic player. He's going to give you things, and he also has the element with his feet. We definitely understood that, knowing their playbook now opened up to some other plays.''

The Bills suddenly were backpedaling down the field when Manziel drove the Browns 80 yards in eight plays for their only touchdown, which he scored on a 10-yard run.

Buffalo's defense seemed to find a comfort zone defending Hoyer, who managed just one play of more than 20 yards. Safety Da'Norris Searcy intercepted two Hoyer passes and dropped two others.

Searcy said players in the defensive huddle were telling each other "watch out for this and watch out for that.''

"Once you notice those tendencies, you are able to play certain formations and jump certain routes,'' Searcy said.

That comfort zone dissipated when Manziel entered the game in the fourth quarter and the Browns attempted to rally from a 20-3 deficit. It was a short-lived rally and the Bills won, 26-10.

"He finished plays a lot more. He's real good on his feet,'' safety Aaron Williams said. "He's always been like that since he was in college. We had to keep the outside pocket contained, and I felt like sometimes he got outside that pocket. When that happens, it's longer for us to cover.

"Sometimes a guy makes plays, and you have to tip your hat to him.''

Hughes said he didn't follow Manziel because he's a Texas Christian product and Manziel played at Texas A&M.

"Go Frogs,'' he added wryly.

Williams, who is from Texas and played at the University of Texas, professed no such ignorance.

"I've known Manziel for a while. I know he's a playmaker,'' Williams said. "He was goofing around after the game and said, 'I didn't think I was going to come in today.'

"His name was called and he did a great job and got a score, unfortunately. Props to him.''

Williams said the defense always prepares some for a backup quarterback, especially when it's a severe change of gears the more mobile Manziel presents compared to Hoyer. Buffalo coach Doug Marrone said that preparation was limited because there is so little meaningful film on Manziel with the Browns.

"I think you've got to see what happens first,'' Marrone said. "You've got to see how he plays. You've just have to make sure of some of the contain elements that you've got to take care of because, obviously, he can run.

"We faced that the week before with Michael Vick, but he has the ability to run the football, and he showed that today.''

Manziel completed five of eight passes for 63 yards and he had a 3-yard run in addition to the touchdown. He also was flattened on a scramble and fumbled into the end zone in what initially was ruled a Bills touchdown, but was reversed to an incomplete pass.