> The cases have in common overlapping features of toxic shock syndrome and atypical Kawasaki Disease with blood parameters consistent with severe COVID-19 in children.

>“Abdominal pain and gastrointestinal symptoms have been a common feature as has cardiac inflammation. This has been observed in children with confirmed PCR positive SARS-CoV-2 infection as well as children who are PCR negative. Serological evidence of possible preceding SARS-CoV-2 infection has also been observed.”

>PICS advised “early discussion” of possible cases “with regional paediatric infectious disease and critical care teams”.

> FCoV is a virus of the gastrointestinal tract: most infections are either asymptomatic, or cause diarrhea, especially in kittens, as maternally derived antibody wanes at between 5 and 7 weeks of age. The virus is a mutation of feline enteric coronavirus (FECV).

> An intense inflammatory reaction to FIPV occurs around vessels in the tissues where these infected cells locate, often in the abdomen, kidney, or brain. It is this interaction between the body’s own immune system and the virus that is responsible for the development of FIP. Once a cat develops clinical FIP, the disease is usually progressive and almost always fatal without therapy that has recently become available, but that has yet to be approved to treat FIP in cats by the Food and Drug Administration (FDA)