ROME (AP) — Expressing increasing alarm about mounting infections, the World Health Organization declared Wednesday that the global coronavirus crisis is now a pandemic.

Tedros Adhanom Ghebreyesus, who heads the U.N. agency, said the WHO is “deeply concerned by the alarming levels of spread and severity” of the outbreak. He also expressed concern about “the alarming levels of inaction.”

“We have, therefore, made the assessment that COVID-19 can be characterized as a pandemic,” he said at a briefing.

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Italy weighed imposing even tighter restrictions on daily life and announced billions in financial relief Wednesday to cushion economic shocks from the coronavirus, its latest efforts to adjust to the fast-evolving health crisis that silenced the usually bustling heart of the Catholic faith, St. Peter’s Square.

In Iran, by far the hardest-hit country in the Middle East, the senior vice president and two other Cabinet ministers were reported to have been diagnosed with COVID-19, the illness caused by the virus. Iran reported another jump in deaths, by 62 to 354 — behind only China and Italy.

In Italy, Premier Giuseppe Conte said he would consider requests from Lombardy, Italy’s hardest-hit region, to toughen the already extraordinary anti-virus lockdown that was extended nationwide Tuesday. Lombardy wants to shut down nonessential businesses and reduce public transportation.

“All countries can still change the course of this pandemic. If countries detect, test, treat, isolate, trace and mobilize their people in the response,” Tedros said.

These additional measures would be on top of travel and social restrictions that imposed an eerie hush on cities and towns across the country from Tuesday. Police enforced rules that customers stay 1 meter (3 feet) apart and ensured that businesses closed by 6 p.m.

Milan shopkeeper Claudia Sabbatini said she favored stricter measures. Rather than run the risk of customers possibly infecting each other in her children’s clothing store, she decided to close it.

“I cannot have people standing at a distance. Children must try on the clothes. We have to know if they will fit,’’ she said.

Conte said fighting Italy’s more than 10,000 infections — the biggest outbreak outside of China — must not come at the expense of civil liberties. His caution suggested that Italy is unlikely to adopt the draconian quarantine measures that helped China push down new infections from thousands per day to a trickle now and allowed its manufacturers to restart production lines.

China’s new worry is that the coronavirus could re-enter from abroad. Beijing’s city government announced that all overseas visitors will be quarantined for 14 days. Of 24 new cases that China reported Wednesday, five arrived from Italy and one from the United States. China has had over 81,000 virus infections and over 3,000 deaths.

For most, the coronavirus causes only mild or moderate symptoms, such as fever and cough. But for a few, especially older adults and people with existing health problems, it can cause more severe illnesses, including pneumonia. More than 121,000 people have been infected worldwide and over 4,300 have died.

But the vast majority of people recover. According to the World Health Organization, people with mild illness recover in about two weeks, while those with more severe illness may take three to six weeks to recover.

In the Mideast, the vast majority of the nearly 10,000 cases are in Iran or involve people who traveled there. Iran announced another increase in cases Wednesday to 9,000. Iran’s semiofficial Fars news agency said they include Vice President Eshaq Jahangiri, who had not been seen in photos of recent top-level meetings. Fars said Iran’s ministers for cultural heritage, handcrafts and tourism, and for industry, mines and business were also infected.

Cases in Qatar jumped from 24 to 262. Kuwait announced a two-week shutdown of the country.

For the global economy, virus repercussions were profound, with increasing concerns of wealth- and job-wrecking recessions. U.S. stocks sank again in early trading Wednesday, wiping out most of a huge rally from a day earlier as Wall Street continues to reel from worries about the coronavirus.

The Wall Street plunge followed a steep decline by markets across Asia, where governments there and elsewhere have announced billions of dollars in stimulus funds, including packages revealed in Japan on Tuesday and Australia on Wednesday.

Italy’s government announced Wednesday it was earmarking 25 billion euros (nearly $28 billion) to boost anti-virus efforts and soften economic blows, including delaying tax and mortgage payments by families and businesses.

Britain’s government announced a 30 billion-pound ($39 billion) economic stimulus package and the Bank of England slashed its key interest rate by half a percentage point to 0.25%.

Normal life was increasingly being upended.

With police barring access to St. Peter’s Square, emptying it of tens of thousands of people who usually come on Wednesdays for the weekly papal address, Pope Francis instead live-streamed prayers from the privacy of his Vatican library.

In France, the government’s weekly Cabinet meeting was moved to a bigger room so President Emmanuel Macron and his ministers could sit at least 1 meter (more than 3 feet) apart.

Athletes who usually thrive on crowds grew increasingly wary of them. Spanish soccer club Getafe said it wouldn’t travel to Italy to play Inter Milan, preferring to forfeit their Europa League match rather than risk infections.

Olympic champion skier Mikaela Shiffrin said she would be limiting contact with fans and fellow competitors, tweeting that “this means no selfies, autographs, hugs, high fives, handshakes or kiss greetings.”

In the U.S., the caseload passed 1,000, and outbreaks on both sides of the country stirred alarm.

Former U.S. Vice President Joe Biden and Sen. Bernie Sanders, who are vying to take on President Donald Trump in the presidential election, abruptly canceled rallies Tuesday and left open the possibility that future campaign events could be impacted, too. Trump’s campaign insisted it would proceed as normal, although Vice President Mike Pence conceded future rallies would be evaluated “on a day to day basis.”

In Europe, deaths soared among Italy’s aging population. Authorities said Italy has suffered 631 deaths, with an increase of 168 fatalities recorded Tuesday. In Spain, the number of cases surged past the 2,000-mark on Wednesday. Belgium, Bulgaria, Sweden and Albania announced their first virus-related deaths.

“If you want to be blunt, Europe is the new China,” said Robert Redfield, the head of the U.S. Centers for Disease Control and Prevention.

Also sounding the alarm at a Congressional hearing in Washington was Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases.

“Bottom line, it’s going to get worse,” he said.

In Germany, Chancellor Angela Merkel said that if the virus is not halted by vaccines and cures, up to 70% of the country’s 83 million people could ultimately become infected, citing estimates that epidemiologists have been putting forward for several weeks. Germany has some 1,300 confirmed infection. Merkel’s comments fit a pattern of government officials using sobering warnings to try to get people to protect themselves, most notably by washing their hands and not gathering in large numbers.

Dozens of cases have been tied to a conference in Boston, and leaders in multiple states were announcing curbs on large events. Colleges emptied their classrooms as they moved to online instruction and uncertainty surrounded the upcoming opening of the major league baseball season and college basketball’s championships. Even the famed buffets of Las Vegas were affected, with some of the Strip’s biggest being closed as a precaution.

“It’s terrifying,” said Silvana Gomez, a student at Harvard University, where undergraduates were told to leave campus by Sunday. “I’m definitely very scared right now about what the next couple days, the next couple weeks look like.”