(CNN) Sen. Elizabeth Warren delivered a fiery condemnation of Donald Trump on Tuesday, continuing her role as an unflinching antagonist to the presumptive Republican nominee and leading both high profile politicians to sharply and publicly mock each other.

In a speech at the Center for Popular Democracy's annual gala, the progressive stalwart took aim at Trump's business record and populist rhetoric during a 10-minute invective, and Trump responded by calling Warren "Pocahontas," reviving a 2012 controversy how the Massachusetts senator described her Native American heritage.

Warren portrayed the billionaire real estate mogul as uncaring and dishonest -- picking up on Trump's comments he made about the 2008 financial crisis.

"What kind of a man roots for people to get thrown out of their houses? What kind of a man roots for people to get thrown out of their jobs? To root for people to lose their pensions?" Warren asked.

Photos: Elizabeth Warren's career Photos: Elizabeth Warren's career Sen. Elizabeth Warren addresses a rally in support of Social Security and Medicare on Capitol Hill on September 18, 2014, in Washington, D.C. Hide Caption 1 of 17 Photos: Elizabeth Warren's career President Barack Obama (right) speaks as Warren and Labor Secretary Tom Perez listen at an AARP conference, February 23, 2015 in Washington, D.C. Hide Caption 2 of 17 Photos: Elizabeth Warren's career Warren (2nd from left) speaks as Senate Majority Whip Sen. Richard Durbin, D-Illinois, (left), Sen. Patty Murray, D-Washington, (3rd from left) and Sen. Chuck Schumer, D-New York, (right) listen during a news conference on college affordability on June 5, 2014, on Capitol Hill. Hide Caption 3 of 17 Photos: Elizabeth Warren's career Democratic Senators Barabara Mikulski, Debbie Stabenow, Warren, Tammy Baldwin and Amy Klobuchar at a news conference to announce their support for raising the minimum wage to $10.10 at the U.S. Capitol on January 30, 2014. Hide Caption 4 of 17 Photos: Elizabeth Warren's career Then-nominee for the Federal Reserve Board Chairman Janet Yellen (left) shakes hands with Warren (Right) after her confirmation hearing before Senate Banking, Housing and Urban Affairs Committee on November 14, 2013, on Capitol Hill. Hide Caption 5 of 17 Photos: Elizabeth Warren's career Warren speaks at a press conference on April 16, 2013, in Boston, one day after the Boston Marathon bombing. Hide Caption 6 of 17 Photos: Elizabeth Warren's career Senate Banking, Housing and Urban Affairs Committee members (right to left) Sen. Joe Manchin, Warren and Heidi Heitkamp participate in a hearing with then-Federal Reserve Bank Chairman, Ben Bernanke, after the release of The Semiannual Monetary Policy Report to the Congress on February 26, 2013, in Washington, D.C. Hide Caption 7 of 17 Photos: Elizabeth Warren's career (Left to right): John Kerry, Warren, then-Secretary of State Hillary Clinton and Sen. John McCain, are seated at Kerry's State Department confirmation hearings on Capitol Hill on January 24, 2013. Hide Caption 8 of 17 Photos: Elizabeth Warren's career Warren participates in a ceremonial swearing-in with her husband Bruce Mann and Vice President Joe Biden in the Old Senate Chamber on January 3, 2013, in Washington, D.C. Hide Caption 9 of 17 Photos: Elizabeth Warren's career Warren takes the stage for her acceptance speech after beating the incumbent Sen. Scott Brown on November 6, 2012, in Boston, Massachusetts. Hide Caption 10 of 17 Photos: Elizabeth Warren's career Then-Massachusetts Senatorial candidate Warren speaks at the Democratic National Convention on September 5, 2012, in Charlotte, North Carolina. Hide Caption 11 of 17 Photos: Elizabeth Warren's career President Obama (left) and former financial adviser Elizabeth Warren (left) arrive at the nomination of former Ohio Attorney General Richard Cordray (right) to lead a consumer protection bureau at the White House on July 18, 2011. Hide Caption 12 of 17 Photos: Elizabeth Warren's career Warren, the former Assistant to the President and Special Adviser to the Secretary of Treasury on the Consumer Financial Protection Bureau, testifies on TARP (The Troubled Asset Relief Program) and Bailouts of Public and Private Programs during a hearing on Capitol Hill on May 24, 2011. Hide Caption 13 of 17 Photos: Elizabeth Warren's career Warren (far right), an assistant to the President at the time, speaks at the Fortune Most Powerful Women summit on October 5, 2010, in Washington, D.C. Hide Caption 14 of 17 Photos: Elizabeth Warren's career President Obama (center), with then-Treasury Secretary Timothy Geithner (left) looking on, appoints former Congressional Oversight Panel Chair, Warren (right), to assistant and special adviser to the Secretary of the Treasury on the Consumer Financial Protection Bureau on September 17, 2010. Hide Caption 15 of 17 Photos: Elizabeth Warren's career (Left to right) Former Harvard Law Professor Warren talks with former White House Economic Recovery Advisory Board Chairman Paul Volcker and former Commerce Secretary Gary Locke before the signing ceremony for the financial reform bill on July 21, 2010. Hide Caption 16 of 17 Photos: Elizabeth Warren's career Then-Democratic presidential candidate Barack Obama (center) listens to questions with Rosa Figueroa (left) and Warren while hosting an economic round table at the Illinois Institute of Technology on June 11, 2008, in Chicago. Hide Caption 17 of 17

"I'll tell you exactly what kind of a man does that," she continued. "It is a man who cares about no one but himself. A small, insecure, money-grubber who doesn't care who gets hurt, so long as he makes a profit off it."

reflects an eagerness among top Democrats to pivot toward a general election footing. Warren has frequently attacked Trump using the real estate mogul's trademark medium Twitter, but Tuesday's verbal broadside comes as the Massachusetts Democrat continues to stay uncommitted in her party's presidential primary. An oft-speculated vice presidential pick, Warren has professed neutrality between Hillary Clinton and Bernie Sanders -- though her willingness to hit Trump hard

Trump, for his part, has fired back at Warren on Twitter, calling her "goofy" and questioning her Senate record.

JUST WATCHED Elizabeth Warren stands up to Trump on Twitter Replay More Videos ... MUST WATCH Elizabeth Warren stands up to Trump on Twitter 02:43

Speaking at a rally in Albuquerque, New Mexico, Tuesday night, Trump also called Warren "Pocahontas," a reference to how her past description of her native American heritage became a divisive campaign issue during his bid to become senator in 2012.

"Elizabeth Warren, she is going out -- she is probably the senator that is doing just about the least in the United States senate," Trump told his audience. "She is a total failure."

He followed up with a tweet Wednesday morning, writing , "Goofy Senator Elizabeth Warren @elizabethforma has done less in the U.S. Senate than practically any other senator. All talk, no action!"

During her speech, Warren fiercely rejected Trump's effort to portray himself as tough on Wall Street, saying, "Now that he has sewn up the Republican nomination, Donald Trump has dropped all pretense. He is kissing the fannies of the poor, misunderstood Wall Street bankers."

"Donald Trump is worried about helping poor little Wall Street -- let me find the world's smallest violin to play a sad, sad song," she joked.

The Massachusetts senator also hit the presumptive Republican nominee for his unwillingness to release his tax returns , noting that while every presidential candidate since 1976 has done so, "he doesn't think that the rules that apply to everyone else should apply to him."

Photos: Donald Trump's rise Photos: Donald Trump's rise President-elect Donald Trump has been in the spotlight for years. From developing real estate and producing and starring in TV shows, he became a celebrity long before winning the White House. Hide Caption 1 of 37 Photos: Donald Trump's rise Trump at age 4. He was born in 1946 to Fred and Mary Trump in New York City. His father was a real estate developer. Hide Caption 2 of 37 Photos: Donald Trump's rise Trump, left, in a family photo. He was the second-youngest of five children. Hide Caption 3 of 37 Photos: Donald Trump's rise Trump, center, stands at attention during his senior year at the New York Military Academy in 1964. Hide Caption 4 of 37 Photos: Donald Trump's rise Trump, center, wears a baseball uniform at the New York Military Academy in 1964. After he graduated from the boarding school, he went to college. He started at Fordham University before transferring and later graduating from the Wharton School, the University of Pennsylvania's business school. Hide Caption 5 of 37 Photos: Donald Trump's rise Trump stands with Alfred Eisenpreis, New York's economic development administrator, in 1976 while they look at a sketch of a new 1,400-room renovation project of the Commodore Hotel. After graduating college in 1968, Trump worked with his father on developments in Queens and Brooklyn before purchasing or building multiple properties in New York and Atlantic City, New Jersey. Those properties included Trump Tower in New York and Trump Plaza and multiple casinos in Atlantic City. Hide Caption 6 of 37 Photos: Donald Trump's rise Trump attends an event to mark the start of construction of the New York Convention Center in 1979. Hide Caption 7 of 37 Photos: Donald Trump's rise Trump wears a hard hat at the Trump Tower construction site in New York in 1980. Hide Caption 8 of 37 Photos: Donald Trump's rise Trump was married to Ivana Zelnicek Trump from 1977 to 1990, when they divorced. They had three children together: Donald Jr., Ivanka and Eric. Hide Caption 9 of 37 Photos: Donald Trump's rise The Trump family, circa 1986. Hide Caption 10 of 37 Photos: Donald Trump's rise Trump uses his personal helicopter to get around New York in 1987. Hide Caption 11 of 37 Photos: Donald Trump's rise Trump stands in the atrium of the Trump Tower. Hide Caption 12 of 37 Photos: Donald Trump's rise Trump attends the opening of his new Atlantic City casino, the Taj Mahal, in 1989. Hide Caption 13 of 37 Photos: Donald Trump's rise Trump signs his second book, "Trump: Surviving at the Top," in 1990. Trump has published at least 16 other books, including "The Art of the Deal" and "The America We Deserve." Hide Caption 14 of 37 Photos: Donald Trump's rise Trump and singer Michael Jackson pose for a photo before traveling to visit Ryan White, a young child with AIDS, in 1990. Hide Caption 15 of 37 Photos: Donald Trump's rise Trump dips his second wife, Marla Maples, after the couple married in a private ceremony in New York in December 1993. The couple divorced in 1999 and had one daughter together, Tiffany. Hide Caption 16 of 37 Photos: Donald Trump's rise Trump putts a golf ball in his New York office in 1998. Hide Caption 17 of 37 Photos: Donald Trump's rise An advertisement for the television show "The Apprentice" hangs at Trump Tower in 2004. The show launched in January of that year. In January 2008, the show returned as "Celebrity Apprentice." Hide Caption 18 of 37 Photos: Donald Trump's rise A 12-inch talking Trump doll is on display at a toy store in New York in September 2004. Hide Caption 19 of 37 Photos: Donald Trump's rise Trump attends a news conference in 2005 that announced the establishment of Trump University. From 2005 until it closed in 2010, Trump University had about 10,000 people sign up for a program that promised success in real estate. Three separate lawsuits -- two class-action suits filed in California and one filed by New York's attorney general -- argued that the program was mired in fraud and deception. Trump's camp rejected the suits' claims as "baseless." And Trump has charged that the New York case against him is politically motivated. Hide Caption 20 of 37 Photos: Donald Trump's rise Trump attends the U.S. Open tennis tournament with his third wife, Melania Knauss-Trump, and their son, Barron, in 2006. Trump and Knauss married in 2005. Hide Caption 21 of 37 Photos: Donald Trump's rise Trump wrestles with "Stone Cold" Steve Austin at WrestleMania in 2007. Trump has close ties with the WWE and its CEO, Vince McMahon. Hide Caption 22 of 37 Photos: Donald Trump's rise For "The Apprentice," Trump was honored with a star on the Hollywood Walk of Fame in January 2007. Hide Caption 23 of 37 Photos: Donald Trump's rise Trump appears on the set of "The Celebrity Apprentice" with two of his children -- Donald Jr. and Ivanka -- in 2009. Hide Caption 24 of 37 Photos: Donald Trump's rise Trump poses with Miss Universe contestants in 2011. Trump had been executive producer of the Miss Universe, Miss USA and Miss Teen USA pageants since 1996. Hide Caption 25 of 37 Photos: Donald Trump's rise In 2012, Trump announces his endorsement of Republican presidential candidate Mitt Romney. Hide Caption 26 of 37 Photos: Donald Trump's rise Trump speaks in Sarasota, Florida, after accepting the Statesman of the Year Award at the Sarasota GOP dinner in August 2012. It was shortly before the Republican National Convention in nearby Tampa. Hide Caption 27 of 37 Photos: Donald Trump's rise Trump appears on stage with singer Nick Jonas and television personality Giuliana Rancic during the 2013 Miss USA pageant. Hide Caption 28 of 37 Photos: Donald Trump's rise In June 2015, during a speech from Trump Tower, Trump announced that he was running for President. He said he would give up "The Apprentice" to run. Hide Caption 29 of 37 Photos: Donald Trump's rise Trump -- flanked by U.S. Sens. Marco Rubio, left, and Ted Cruz -- speaks during a CNN debate in Miami on March 10. Trump dominated the GOP primaries and emerged as the presumptive nominee in May. Hide Caption 30 of 37 Photos: Donald Trump's rise The Trump family poses for a photo in New York in April. Hide Caption 31 of 37 Photos: Donald Trump's rise Trump speaks during a campaign event in Evansville, Indiana, on April 28. After Trump won the Indiana primary, his last two competitors dropped out of the GOP race. Hide Caption 32 of 37 Photos: Donald Trump's rise Trump delivers a speech at the Republican National Convention in July, accepting the party's nomination for President. "I have had a truly great life in business," he said. "But now, my sole and exclusive mission is to go to work for our country -- to go to work for you. It's time to deliver a victory for the American people." Hide Caption 33 of 37 Photos: Donald Trump's rise Trump faces Democratic nominee Hillary Clinton in the first presidential debate, which took place in Hempstead, New York, in September. Hide Caption 34 of 37 Photos: Donald Trump's rise Trump apologizes in a video, posted to his Twitter account in October, for vulgar and sexually aggressive remarks he made a decade ago regarding women. "I said it, I was wrong and I apologize," Trump said, referring to lewd comments he made during a previously unaired taping of "Access Hollywood." Multiple Republican leaders rescinded their endorsements of Trump after the footage was released. Hide Caption 35 of 37 Photos: Donald Trump's rise Trump walks on stage with his family after he was declared the election winner on November 9. "Ours was not a campaign, but rather, an incredible and great movement," he told his supporters in New York. Hide Caption 36 of 37 Photos: Donald Trump's rise Trump is joined by his family as he is sworn in as President on January 20. Hide Caption 37 of 37

"Maybe he is just a lousy businessman and he just doesn't want everyone to know that he's not as rich as he claims to be. But...the last time that his taxes were made public, Donald Trump paid nothing. Zero," she noted, referencing a Washington Post report that revealed Trump had paid no taxes when his returns were made public in 1981.

Warren then skewered Trump for defending his desire to avoid paying taxes: "Two weeks ago, he said that he was more than happy to dodge taxes because he doesn't want to throw his money, quote, 'down the drain.'"

"Let's be clear," Warren said. "Nurses and teachers and dockworkers, they pay their fair share to keep Trump's businesses going. Programmers and engineers and small business owners, they pay their fair share to support our military, who show courage and sacrifice every day."

"Donald Trump thinks that supporting them is throwing money down the drain? Then I say we throw Donald Trump down the drain."