The Panthers and Buccaneers kicked off in London at 9:30 AM EST but make sure you check out who is active and who isn’t before the afternoon slate of games while you set your lineups:

Noteworthy Inactives

Mason Rudolph, QB, Pittsburgh Steelers (concussion) – Mason Rudolph was ruled out of Sunday’s game against the Chargers after taking a nasty hit during Week 5. Devlin Hodges will get the start per ESPN’s Adam Schefter.

Todd Gurley II, RB, Los Angeles Rams (quad) – Todd Gurley was ruled out on Saturday, per the Rams. Gurley was listed as doubtful earlier in the week and head coach Sean McVay said he would defer to Gurley in terms of his availability. Running backs Malcolm Brown and Darrell Henderson should split the workload.

Justin Jackson, RB, Los Angeles Chargers (calf) – After missing practice all week, Justin Jackson is not expected to start according to ESPN. Jackson is not fantasy relevant anymore with Melvin Gordon back and Austin Ekeler running well.

Rashaad Penny, RB, Seattle Seahawks (hamstring) – Rashaad Penny is inactive for Sunday’s matchup against the Browns. Chris Carson should be the workhorse back for Seattle.

Davante Adams, WR, Green Bay Packers (toe) – The Packers ruled out receiver Davante Adams on Saturday for their Monday matchup against the Lions. Adams has been dealing with turf toe since Week 4 and it was unlikely he was going to play this week.

Sammy Watkins, WR, Kansas City Chiefs (hamstring) – Sammy Watkins will not play in Week 6 against the Texans per Schefter. Watkins barely played in Week 5 against the Colts — he left during the first quarter after aggravating his hamstring.

Christian Kirk, WR, Kansas City Chiefs (ankle) – Christian Kirk is not expected to play against the Falcons in Week 6 due to an ankle injury per Adam Schefter. Larry Fitzgerald and Pharoh Cooper should see increased targets.

Marquise Brown, WR, Baltimore Ravens (ankle) – Marquise “Hollywood” Brown is inactive for Sunday’s matchup against the Bengals. It was looking like a game-time decisions throughout the week. With the dearth of receivers on the Ravens, Mark Andrews should see some additional targets as a result.

A.J. Green, WR, Cincinnati Bengals (foot) – A.J. Green returned to practice for the first time since training camp this week. He is listed as week-to-week and he could come back as early as Week 7. He is inactive for this game, however.

DeSean Jackson, WR, Philadelphia Eagles (abdomen) – DeSean Jackson was ruled out of the Eagles Week 6 matchup against the Vikings on Friday, per NFL insider Adam Caplin. Jackson has been rehabbing from an abdominal injury and per coach Doug Pederson, he has started to run and work off to the side.

Kenny Stills, WR, Houston Texans (hamstring) – Kenny Stills is inactive for Sunday’s game against the Chiefs, per ESPN. Stills injured his hamstring and ankle in Week 4 against the Panthers, which forced him to exit the game. Slot receiver Keke Coutee should see an increase in targets.

Tre’Quan Smith, WR, New Orleans Saints (ankle) – It was announced on Friday that Tre’Quan Smith was ruled out of Sunday’s game against the Jaguars after missing practice all week. Smith exited last week’s game agains the Buccaneers with an ankle injury. In his absence, Michael Thomas and Ted Ginn Jr. will shoulder the targets as the unrivaled No. 1 and 2 on this team.

Chris Herndon, TE, New York Jets (hamstring) – Chris Herndon was looking to make his season debut against the Cowboys this Sunday after returning from his four game suspension. However, however he suffered a grade 1 hamstring injury while running routes on Friday and will miss Week 6 and possibly Week 7.

Jordan Reed, TE, Washington Redskins (concussion) – Jordan Reed was placed on injured reserve on Saturday after missing five weeks in the concussion protocol per NFL insider Adam Caplan. Reed has suffered multiple concussions throughout his career.

Vernon Davis, TE, Washington Redskins (concussion) – Vernon Davis was also ruled out on Friday’s injury report for their Sunday matchup against the Dolphins. Davis is still in the concussion protocol after taking a hit in Week 4 against the Giants. Jeremy Sprinkle and Jerome Cunningham will be the available tight ends with both Reed and Davis out.

Noteworthy Actives

Sam Darnold, QB, New York Jets (mononucleosis) – Sam Darnold will get the Week 6 start against the Cowboys after being cleared for return this week from his bout with mono. Aside from the obvious symptoms of mono, there were concerns that Darnold’s enlarged spleen was susceptible to rupture. His return helps all members of the Jets offense, as he is a big step up from Luke Falk, who stepped in during Darnold’s absence and was waived on Saturday. David Fales will serve as Darnold’s backup today.

Alvin Kamara, RB, New Orleans Saints (ankle) – Alvin Kamara is active in Week 6 against the Jaguars per Melanie Collins of CBS. There were midweek concerns he would not suit up after after tweaking his ankle this week which forced him to miss practice.

David Johnson, RB, Arizona Cardinals (back) – Schefter reported on Sunday that David Johnson is expected to play after being listed as questionable. You can probably bench waiver pick up Chase Edmonds this week.

Chris Carson, RB, Seattle Seahawks (shoulder) – Chris Carson was a limited participant in Thursday’s practice with a sore shoulder, but he practiced in full on Friday and is ready to go against the Browns. His backup, Rashaad Penny, is listed as questionable.

Jamaal Williams, RB, Green Bay Packers (concussion) – Two weeks after taking a very scary hit against the Eagles, Jamaal Williams has been cleared from the concussion protocol per the Packers.

Kalen Ballage, RB, Miami Dolphins (foot) – Kalen Ballage is active for Sunday’s game after being limited in practice on Friday. He had been dealing with a foot injury and was questionable going into the game.

Tyreek Hill, WR, Kansas City Chiefs (clavicle) – Tyreek Hill has been cleared to play and will play in Sunday’s game against the Texans according to Schefter. Hill has been dealing with a clavicle injury all season. His presence will downgrade any fantasy value for Mecole Hardman, Demarcus Robinson and Byron Pringle.

Brandin Cooks, WR, Los Angeles Rams (concussion) – Brandin Cooks has not experienced symptoms from a concussion this week and is expected to play in Week 6, per NBC’s Jennifer Lee Chan.

Mark Andrews, TE, Baltimore Ravens (shoulder) – Adam Schefter reported on Sunday that Mark Andrews will play against the Bengals. Andrews has been dealing with a foot injury and missed practice due to an unrelated shoulder injury on Wednesday. He returned to practice on Thursday and practiced in full on Friday. He should see more targets with receiver Marquise Brown sidelined.

Hunter Henry, TE, Los Angeles Chargers (knee) – Hunter Henry is set to make his first appearance on Sunday against the Steelers since his injury in Week 1 per Schefter. He has missed the past four games dealing with a tibia plateau fracture to his knee, but participated in full in Friday’s practice. Temper expectations for fantasy, however: Head coach Anthony Lynn said Henry would be on a snap count and he would “put him out there for a few plays.”

Vance McDonald, TE, Pittsburgh Steelers (shoulder) – Vance McDonald will play on Sunday against the Chargers, as reported by Tribune-Review’s Chris Adamski.

George Kittle, TE, San Francisco 49ers (groin) – George Kittle is expected to play after a late appearance on the injury report with a groin issue per Schefter. He may be limited amidst concerns he may not be able to finish the game, however.

Still Questionable

Randall Cobb, WR, Dallas Cowboys (back, hip) – The Cowboys will determine if Randall Cobb can play after he takes pre-game workouts, per Ian Rapoport. He is likely a game-time decision.

T.J. Hockenson, TE, Detroit Lions (concussion) – T.J. Hockenson returned to practice on Wednesday and practiced in full on Thursday, despite still being in the concussion protocol. If he clears the protocol, he should play on Monday night against the Packers. If you want to play it safe, however, with Hockenson playing on Monday, start someone with a game on Sunday instead.