More than $500,000 believed to be the proceeds of crime has been seized in Adelaide and three men with links to the Descendants bikie gang arrested in a major police operation.

The Australian Federal Police said raids were conducted across the city on Wednesday and Thursday this week with officers also seizing one kilogram of methamphetamine along with four vehicles and prohibited weapons.

They alleged the men arrested had links to a syndicate operating within the Descendants which had been heavily involved in the distribution of methamphetamine since early 2016.

AFP organised crime manager acting commander Peter Bodel said the joint operation with SA police was about keeping communities safe from individuals and groups operating outside of the law.

"This kind of activity, which sees methamphetamine distributed throughout our towns and cities, is extremely harmful to individuals, families and whole communities," he said in a statement.

Those arrested were two men aged 32 and 36 who were both charged with drug trafficking and dealing in the proceeds of crime, while a 46-year-old man was charged with drug trafficking.

The officer in charge of South Australia's serious and organised crime branch Mark Trenwith said the demand for methamphetamine was a problem in SA.

"There are significant economic and social flow-on impacts of illegal drug use in the community, from the burden on health services to the heartache experienced by so many families," he said.

"We hope this activity sends a message that this kind of illegal activity in South Australia won't be tolerated."