Socceroos coach Ange Postecoglou could lose several more key players to injury for Thursday's (AEDT) friendly with world champions Germany in Kaiserslautern.

With big guns such as Tim Cahill and Matthew Spiranovic already absent, Postecoglou appears likely to lose at least two more first-team players sitting on the sidelines.

Asian Cup star Massimo Luongo (groin) might have to be saved for next week's clash with Macedonia, while defender Trent Sainsbury (knee) also sat out the start of training in Mainz.

It means Postecoglou will field a team relatively light on international experience against Joachim Loew's star-studded line-up, though the German may also tweak his side ahead of next week's Euro 2016 qualifier against Georgia.

If Sainsbury misses out it could open the door for Preston North End defender Bailey Wright to partner Alex Wilkinson in central defence for his second Socceroos cap.

It would be a daunting assignment for the 22-year-old against a German team that put seven goals on Brazil in the World Cup semi-finals.

Attack is also an area of concern for Postecoglou, with a groin problem to Tomi Juric possibly paving the way for Nathan Burns to start either up front or as a winger.

Postecoglou has shown he is not afraid to expose young and inexperienced players to the harshest of environments and he is planning to stick with the approach on the road to Russia 2018.

Skipper Mile Jedinak is backing whoever is called upon to step up.

"It's been great to see how such a younger core group of players has been able to mature and I think having the success that we did at the Asian Cup, it's taken them and taken us to another level," Jedinak said.

"It's a great game to be involved in. It's a mammoth task to play the world champions in their own backyard but a good measuring stick to see where we're at.

"To try and be the best, you have to play the best."

Both sides have had less than two days to prepare but Postecoglou is determined to approach the match just like any other.

"We've played a lot of top 10 sides and not once have we spoken about just trying to stop the opposition," Postecoglou said.

"Especially in these friendly games, it's as much about how we can adapt our game and press our game on the opposition.

"You can play a game like this and walk off the pitch and maybe have scratched out a result, get something that everyone deems respectable, but you haven't really tested yourself.

"What we'll do tomorrow night is really test ourselves."

AAP