Russia has information about an attack on Damascus orchestrated by opposition rebels involving chemical weapons that would be blamed on Syria’s Bashar al-Assad in an attempt to frame him, Vladimir Putin has claimed.

Without offering any proof to support the assertion, the Russian President made reference to suburbs in the south of the Syrian capital which he suggested would be the target of the strikes.

He also attempted to link the US strike on a Syrian air base last week with claims about weapons of mass destruction that were used to justify the 2003 invasion of Iraq, saying: "We have seen it all already."

The provocative comments come as the Russian leader warned of the worst relations between Moscow and Washington since the end of the Cold War.

Responding to questions about the escalating dispute with the US, Mr Putin said Moscow would tolerate criticism from the West of its alliance with Mr Assad, but that it remained hopeful that attitudes would eventually soften.

Speaking to reporters on Tuesday - hours before US Secretary of State Rex Tillerson is due to arrive in Moscow - Mr Putin said he would appeal to the Organisation for the Prohibition of Chemical Weapons to investigate the recent alleged chemical attack in Syria.

"We have information from different sources that these provocations - I cannot call them otherwise - are being prepared in other regions of Syria, including in the southern suburbs of Damascus where there are plans to throw some substance and accuse the official Syrian authorities," Mr Putin said, after holding talks with his Italian counterpart Sergio Mattarella.

He added that some countries had voiced their support for the US air strike on Syria in order to build closer relations with the new Trump administration.

Drawing a comparison with the controversy surrounding claims, later proven to be incorrect, of WMDs being stockpiled by the former Iraqi dictator Saddam Hussein, Mr Putin said: "It reminds me of the events in 2003 when US envoys to the [UN] Security Council were demonstrating what they said were chemical weapons found in Iraq."

On the investigation into the chemical attack, Mr Putin said: “We plan to turn to the United Nations bodies in The Hague and call on the global community to thoroughly investigate into this incident and make balanced decisions based on the investigation’s outcome.”

Russian Foreign Minister Sergey Lavrov is to meet Mr Tillerson on Wednesday. Earlier reports suggested Mr Putin would also meet the US diplomat, something Moscow has not commented on.

In pictures: US missile strike against Syria Show all 7 1 /7 In pictures: US missile strike against Syria In pictures: US missile strike against Syria The guided-missile destroyer USS Porter (DDG 78) launches a tomahawk land attack missile in the Mediterranean Sea AP In pictures: US missile strike against Syria The United States military launched at least 50 tomahawk cruise missiles at al-Shayrat military airfield near Homs, Syria, in response to the Syrian military's alleged use of chemical weapons in an airstrike in a rebel held area in Idlib province EPA In pictures: US missile strike against Syria Shayrat airfield in Syria Getty Images In pictures: US missile strike against Syria US Navy guided-missile destroyer USS Ross (DDG 71) fires a tomahawk land attack missile in Mediterranean Sea Reuters In pictures: US missile strike against Syria US Navy guided-missile destroyer USS Ross (DDG 71) fires a tomahawk land attack missile in Mediterranean Sea Reuters In pictures: US missile strike against Syria President Donald Trump speaks at Mar-a-Lago in Palm Beach, Fla., after the US fired a barrage of cruise missiles into Syria in retaliation for this week's gruesome chemical weapons attack against civilians AP In pictures: US missile strike against Syria Syria's President Bashar al-Assad Reuters

Despite heightened tensions between the US and Russia, the foreign ministry has said it continued to hope for “productive talks” with Mr Tillerson.

In a three-page statement issued ahead of his arrival this evening, officials said the outcome of the talks was important not just for Russia-US ties but "for the overall atmosphere on the world stage”.

Russia has been a long-time supporter of Mr Assad's government, which was accused of launching a chemical weapons attack on Idlib province.

That incident prompted Donald Trump to launch a cruise missile strike from two warships based in the Mediterranean targeted at an air base said to have been the base from which the original chemical attack was launched.

Meanwhile, Russia's General Staff has said the Syrian government is willing to let international experts examine its military base for signs of chemical weapons.