Jose Mourinho has ordered a complete review into Manchester United’s medical department after seeing his squad depleted by injuries throughout the start to his reign at Old Trafford, having suffered more player losses than any other club in the Premier League this season.

Mourinho hit the headlines at the weekend when he openly criticised the commitment shown by Chris Smalling and Luke Shaw in their withdrawal from the trip to Swansea, but it appears his concerns go much deeper than just the players’ mentality.

The Times report that Mourinho is “hugely frustrated” with the number of injuries United have suffered this season, with the number of match days lost this season through player injuries reaching 33 at the weekend.

But Mourinho is also keen not to single out any individual among his medical staff for criticism, with the experienced doctor Steve McNally heading the department. Both Shaw and Smalling have been hampered by niggling injuries this season, although the former’s relate to the horrific broken leg he suffered 14 months ago.

However, Mourinho has seen a number of first-team members ruled out over the last three months, with Wayne Rooney, Henrikh Mkhitaryan, Phil Jones and Anthony Martial among those to suffer spells consigned to the sidelines.

Having refused to play Mkhitaryan since the Manchester derby defeat in September, Mourinho finally recalled the Armenian for Thursday’s Europa League loss to Fenerbahce where he came off the substitutes’ bench to play the final half an hour.

Fenerbahce vs Manchester United player ratings Show all 11 1 /11 Fenerbahce vs Manchester United player ratings Fenerbahce vs Manchester United player ratings David de Gea - 6 Caught off his line for opening goal. Put in some important saves to limit the damage. Getty Fenerbahce vs Manchester United player ratings Matteo Darmian - 4 Gave away possession with far too many careless passes. Fenerbahce vs Manchester United player ratings Daley Blind - 5 Put in some important challenges here and there but disappointing as a whole. Getty Fenerbahce vs Manchester United player ratings Marcos Rojo - 4 Poor defensive performance. Caught out on too many occasions. Out of his depth. Fenerbahce vs Manchester United player ratings Luke Shaw - 4 Ineffective down the flank. A number of his deliveries were well off the mark. Confused positioning too when on the front foot. Fenerbahce vs Manchester United player ratings Morgan Schneiderlin - 3 Not enough forward passing and was largely ineffective. Brought off at half-time. Fenerbahce vs Manchester United player ratings Ander Herrera - 5 Handed possession away in a number of dangerous positions. Threatened here and there going forward. Fenerbahce vs Manchester United player ratings Marcus Rashford - 6 Utilised his pace on occasion but ultimately struggled to impress the boss and was substituted early. Getty Fenerbahce vs Manchester United player ratings Paul Pogba - N/A Forced off through injury in opening 20 minutes. Fenerbahce vs Manchester United player ratings Anthony Martial - 6 Provided some clever, piercing passes at times. One of United's few players who looked interested. Getty Fenerbahce vs Manchester United player ratings Wayne Rooney - 6 Deployed higher up the pitch but struggled to deliver. Missed early goalscoring chance but sparkled in dying minutes of the match with wonder strike.

But the handling of his fitness has been a major cause of concern for Mourinho, who was told he was fit to face Manchester City despite suffering a thigh injury while on international duty. Mkhitaryan lasted just 45 minutes before being replaced at half-time by Mourinho, and the winger was subsequently ruled out for nearly two months with the same injury, although it did take three days for him to undergo a scan and determine the extent of the injury.

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The report adds that Mourinho’s methods are also being called into question, with Zlatan Ibrahimovic raising concerns over his fitness and his belief that he has lost some of the sharpness that made him so dangerous at Paris Saint-Germain last season.