“I have resigned from the House Freedom Caucus,” Poe said in a statement. “In order to deliver on the conservative agenda we have promised the American people for eight years, we must come together to find solutions to move this country forward. Saying no is easy, leading is hard, but that is what we were elected to do. Leaving this caucus will allow me to be a more effective Member of Congress and advocate for the people of Texas. It is time to lead.”

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Poe's resignation comes hours after Trump tweeted that the Freedom Caucus, along with cash-flush conservative groups that share its hard-line ideological views, “have saved Planned Parenthood” and Obamacare by opposing the bill.

It's not clear whether Trump's statement had a direct effect on Poe's decision to leave the caucus. He was leaning toward voting for the bill, and he was openly critical of his conservative colleagues as the bill was being pulled from a vote.

As the fallout from Republicans' inability to make good on a major campaign promise continues, the White House and GOP leaders are increasingly vocal about their frustrations with the House Freedom Caucus.

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“We can’t be chasing the perfect all the time,” Reince Priebus, Trump's chief of staff, said Sunday on Fox News, raising the possibility that the White House will put less emphasis on negotiating with the caucus going forward and try to work with Democrats instead.

Despite a half-dozen concessions the White House and GOP House leaders offered on health care to the caucus, its leaders held out support — enough that, when combined with opposition from moderate Republicans, it killed the bill before it could even come to a vote.

The establishment GOP's frustration was channeled in a single tweet over the weekend, not from Trump but from Rep. Austin Scott (Ga.), whose biting accusation raised eyebrows in Republican circles because Scott is not known as a flamethrower:

Poe is not the first lawmaker to resign from the Freedom Caucus.

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In September 2015, Rep. Tom McClintock (R-Calif.) became the first to step away from the group as it threatened to shut down the government over federal funding for Planned Parenthood. In a comment that channels what Trump said Sunday, McClintock protested the group's tactics as playing right into the hands of the Democrats.

“It has thwarted vital conservative policy objectives,” he wrote, “and unwittingly become Nancy Pelosi's tactical ally.”

In October 2015, Rep. Reid J. Ribble (R-Wis.) resigned after the Freedom Caucus played a role in forcing then-Rep. John A. Boehner (R-Ohio) to resign as House speaker.