ISLAMABAD, Pakistan — At least 16 people were killed and five others wounded when an American drone strike hit a suspected Haqqani militant compound in a remote tribal region of northwestern Pakistan late Tuesday, according to Pakistani government and intelligence officials.

The strike was the deadliest since Pakistan’s new prime minister, Nawaz Sharif, took power a month ago and demanded an end to the drone attacks. A local government official said the house had been used by the militants for the past few months.

“At least four missiles were fired from two drones at a house of local tribesmen in Sarai Darpa Khel village at 11 p.m. last night,” said the official, who spoke on condition of anonymity.

A local militant source said that the militants who were killed were from the Haqqani network, a group that is responsible for orchestrating and executing attacks against American and Afghan forces across the border in Afghanistan.