All title screens in the normal version of the game (NOTE: You can get all of these in Wrath of the Lamb as well.)

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After you've collected all items in the game.

After nine Mom's heart kills.

After six Mom's Heart kills.

After first Mom's Heart kill.

Wrath of the Lamb

After beating the Cathedral for the first time.

After beating the Cathedral for the second time.

After beating the Cathedral the third time.

After beating the Cathedral for the fourth time.

After beating the Cathedral for the fifth time.

After beating ??? in the Chest, or previously, beating Isaac with the Polaroid.

After 200 Mom kills.

Atfer you've unlocked every item in the game (including all WoTL items) and unlocked every achievement.

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