The escape of an estimated 56 animals – including lions, tigers, giraffes, camels, and bears – from a Zanesville, Ohio, farm is just the latest and most dramatic in a string of incidents involving exotic pets running wild in the state.

In fact, animal-rights activists tab Ohio as one of the five worst states in the country when it comes to monitoring and regulating exotic animals in residents' backyards, garages, or basements.

“Ohio continues to be a free-for-all for unqualified and inexperienced people keeping dangerous animals,” says Debbie Leahy, the captive wildlife regulatory specialist for the Humane Society of the United States.

The animals in Ohio had been kept in cages at a preserve near Zanesville owned by Terry Thompson, who apparently pried open the animals’ cages and left the farm fences open before killing himself, according to Muskingum County Sheriff Matt Lutz.

Law enforcement officials said Wednesday afternoon they had accounted for all but two of the estimated 56 animals that escaped, 48 of which they killed. Only a wolf and a monkey were still on the loose. So far, no injuries have been reported.

But that has not been the case in the past. In total, the Humane Society documented 22 incidents involving exotic pets in Ohio since 2003, making Ohio one of the top five states for such incidents. They include:

In August last year, a man in Lorain County died after being attacked by a black bear. The owner’s federal license had been revoked, but he kept eight bears, four tigers, one lion, and 12 wolves on the property.

In May 2009, a 10-year-old girl in Columbiana County was bitten by a mountain lion being kept as a pet. The girl had to be airlifted to a hospital for treatment.

In November 2007, a pet lion escaped in Pike County and was seen chasing cars on the street.

In August 2003, a Dayton firefighter died after being bitten by his pet, a poisonous African rhino viper.

Ohio is one of eight states that doesn’t regulate private ownership of animals, according to Humane Society figures. Ms. Leahy says the lack of regulations pose a serious threat to public safety and animal welfare.

Moreover, in this particular occurrence, unprepared and unqualified rural law-enforcement officials have been forced to deal with the escaped animals, and it’s taxpayers who are footing the bill.

“Local authorities are now spending enormous resources on personnel, helicopters, and infrared equipment chasing down and killing free-roaming exotic animals in order to protect public safety,” according to a press release by the Humane Society. “The paucity of rules on this issue is not only a threat to public safety, but also a fiscal drain on government resources.”

Leahy says her organization helped former Ohio Gov. Ted Strickland draft an executive order to prohibit private possession of dangerous wild animals, which he signed upon leaving office, but new Gov. John Kasich does not enforce it.

"There’s a culture of antigovernment regulation where people view these animals as property, and they say, ‘Don’t tell me what I can and cannot do with my property,’ ” she says.

Leahy says that only qualified and accredited zoos and animal sanctuaries should be allowed to lodge exotic and wild animals because “these places have trained individuals who devote significant resources to issues such as environmental enrichment, boredom, and lack of exercise for animals.”

Otherwise, Leahy says, “These animals can literally go insane and will have very neurotic behavior.”

“We don’t fault [law enforcement] for having to use lethal force, because that’s what happens in these situations,” she adds. “But this is not the first time and it won’t be the last time these tragedies happen in states like Ohio that aren’t addressing this issue.”