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Matt Lauer’s long-suffering wife Annette Roque has fled their home and is rumored to have headed back to her native Netherlands amid his sex harassment scandal.

Multiple sources tell Page Six that Dutch-born former model Annette — Lauer’s wife of 20 years — was last seen at their Hamptons home on Wednesday, the day Lauer’s firing was announced.

One Hamptons source told Page Six, “Annette has taken their two younger kids out of school and is believed to have left the US and gone to her family in her native country.” It is believed her mother lives near Amsterdam.

Amid the scandal, Annette has remained silent. She and Lauer have three children, Romy, 14, son Thijs, 11, and oldest son Jack, who is at a prep school outside Manhattan. It is not known if the kids are with Annette or remained at home with Lauer.

Reps for Lauer have repeatedly declined to comment on the state of his marriage or the whereabouts of his wife.

Annette briefly filed for divorce in 2006, claiming she suffered “cruel and inhumane” treatment from Lauer, who she said in legal documents was controlling and demonstrated “extreme anger and hostility.” She withdrew the divorce filing a month later.

Another well-placed source insisted that the reason Annette withdrew her divorce filing is that Lauer offered her a post-nuptial agreement at the time of the filing, offering her up to a rumored $5 million deal to remain in the marriage.

The source said, “Matt needed to stay in the marriage to keep his reputation as America’s nicest dad. He is in fact a great, and very doting dad to his kids, but he is also a terrible husband.”

A rep for Lauer declined to comment about his wife, and the post-nuptial, as did his high-powered attorney William D. Zabel. Roque’s divorce attorney Nancy Chemtob declined to comment.