Like many other celebrities watching from home Wednesday night, Rosie O’Donnell tweeted along with the third presidential debate and repeatedly went off on Republican candidate Donald Trump, at various points calling him an “anus mouth” and an “orange motherf*cker.”

The actress began a series of tweets during the debate by imagining what Trump was writing on the note paper on his podium:

trump writes a note "remember rosie odonnell is fat" #DebateNight — ROSIE (@Rosie) October 20, 2016

O’Donnell continued by calling Trump “cray cray” and criticizing the performance of Fox News’ Chris Wallace, who served as the debate’s moderator:

hillary- ? 1 – ummmm HELL YES – orangeman is cray cray – PAY ATTENTION!!! next — ROSIE (@Rosie) October 20, 2016

WE ARE WOMEN HEAR US ROAR YOU ORANGE MUTHA F&:KER – this pro life moderator from fox – sucks #debatetonight — ROSIE (@Rosie) October 20, 2016

“WE ARE WOMEN HEAR US ROAR YOUR ORANGE MUTHAF**KER,” the 54-year-old comedian tweeted. “This pro life moderator from fox — sucks.”

O’Donnell issued several more tweets before the debate was over, repeatedly criticizing Trump for his pro-Second Amendment positions and alternately calling him a “delusional human being,” a “delusional turd” and a “stupid rich asswipe.”

PRO CHOICE FOREVER – FUCK U TRUMP #debatenight — ROSIE (@Rosie) October 20, 2016

WERE THEY KILLED BY GUNS ORANGE ANUS #debatenight — ROSIE (@Rosie) October 20, 2016

U STUPID LYING ARROGANT ONE SENTENCE SNIFFER — U R A BAD BAD PERSON DONALD – snifffff sifffffff #debatenight — ROSIE (@Rosie) October 20, 2016

anus mouth and squinty eye nod – tells in poker #debatenight — ROSIE (@Rosie) October 20, 2016

i dont know putin – but i know pussy – putin dont like her's — my orange tiny dick – putin loves #debatenight — ROSIE (@Rosie) October 20, 2016

i dont want tumps finger on anyones button – his poor wife #debatenight — ROSIE (@Rosie) October 20, 2016

ALL YOUR BUSINESS DEALS FAIL U DELUSIONAL TURD #debatenight — ROSIE (@Rosie) October 20, 2016

The feud between O’Donnell and Trump dates back nearly a decade and intensified as the billionaire real estate mogul secured the Republican presidential nomination earlier this summer.

Last summer, just a few weeks after Trump had announced his presidential run, O’Donnell said in an interview that she would like to smear period blood on the faces of those people who propagate what she called Trump’s “war on women.”

During the first GOP debate in August, Trump slammed O’Donnell when moderator Megyn Kelly brought up some of the candidate’s comments about women, to which he replied that he said them “only” about O’Donnell.

In April, O’Donnell declared that Trump “isn’t even qualified to run a game show,” and followed up in May by saying that his mouth “looks like an anus” and predicting that the real estate mogul would “never be president.” In a profanity-laced tirade at New York City’s Beacon Theater later that month, the comedian called Trump an “orange piece of sh*t” and said repeatedly that she hates him. She later revealed that her therapist had advised her not to focus her energy on Trump.

O’Donnell was far from the only celebrity to lash out at Trump during Wednesday night’s third and final presidential debate. Celebrities including Bill Maher, Chelsea Handler, Michael Moore, John Cusack, Chloe Grace Moretz and many more all weighed in, with most bashing the Republican candidate:

Oh for fuck sake, if Trump was any more of a pussy he'd have to grab himself. #Debatenight — Bill Maher (@billmaher) October 20, 2016

I love how he imports a wife THEN decides to crack down on immigration. #debate — Chelsea Handler (@chelseahandler) October 20, 2016

Trump stunningly says he won't commit to accepting the results of the election–his subtle call for possible violence. America, silence him! — Michael Moore (@MMFlint) October 20, 2016

Trump cant realize it that he is the poison that needs to be drained from swamp — John Cusack (@johncusack) October 20, 2016

"You can't" trump, you are a petulant little boy — Chloë Grace Moretz (@ChloeGMoretz) October 20, 2016

Well, there you have it. A highly intelligent, experienced woman just debated a giant orange Twitter egg. Your move, America. #debate — J.K. Rowling (@jk_rowling) October 20, 2016

Follow Daniel Nussbaum on Twitter: @dznussbaum