Around the world, pathogens of all types are showing resistance to standard treatment. Failure among so called "drugs of last resort," a decline of disease prevention programs, and shifting climate all present ominous signs for the risk of global infectious disease.

Joining us this week are three professors from the University of Georgia's College of Veterinary Medicine: Dr. Brenton Credille, Dr. Susan Sanchez, and Dr. Catherine Logue. All three have experience in antimicrobial resistance and the connection between humans, animals, the environment, and the pathogens that move among us all.

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Chapters

03:07 Modern Medicine at Risk?

05:54 What is an Antibiotic?

06:39 Resistance: a Response to Attacks

10:12 Resistance to Last Resort Drugs

12:25 Risk of Global Pandemic

18:08 Resistance to Drugs of Last Resort

20:08 Pandemics: Multi-Faceted Problem

20:37 Pandemics: Climate

25:42 Pandemics: Industrial Agriculture and Food Animals

28:09 Interview: Dr Credille

45:05 Interview: Dr Sanchez & Dr. Louge

1:10:28 China

1:11:53 Pandemics: Environment

1:14:39 Pandemic: Socio-Economic

1:18 Global Prevention

1:21:44 Disease Surveillance

1:26:03 Economic Cost

1:29:14 What Can we Do?

1:30:38 What Can we Actually Do?

Antimicrobial Resistance Visualized

Hardvard Medical School

Sources

@misc{gomez_2018, title={Global health experts warn 'you should be freaking out' about the CDC's cuts to disease prevention}, url={https://thinkprogress.org/cdc-cuts-global-disease-prevention-83414d52633d/}, journal={ThinkProgress}, author={Gomez, Amanda Michelle}, year={2018}, month={Feb}} @misc{mckay_2018, title={CDC to Scale Back Work in Dozens of Foreign Countries Amid Funding Worries}, url={https://www.wsj.com/articles/cdc-to-scale-back-work-in-dozens-of-foreign-countries-amid-funding-worries-1516398717}, journal={The Wall Street Journal}, publisher={Dow Jones & Company}, author={McKay, Betsy}, year={2018}, month={Jan}} @misc{mole_2018, title={Deadly superbug just got scarier-it can mysteriously thwart last-resort drug}, url={https://arstechnica.com/science/2018/03/scary-superbug-can-sneakily-dodge-last-resort-drug-and-we-dont-know-how/}, journal={Ars Technica}, author={Mole, Beth}, year={2018}, month={Mar}} @misc{branswell_2018, title={As towns lose their newspapers, disease detectives are left to fly blind}, url={https://www.statnews.com/2018/03/20/news-deserts-infectious-disease/}, journal={STAT}, publisher={STAT}, author={Branswell, Helen}, year={2018}, month={Mar}} @misc{bucay_elliott_kamin_park_2017, title={America's growing news deserts}, url={https://www.cjr.org/local_news/american-news-deserts-donuts-local.php}, journal={Columbia Journalism Review}, author={Bucay, Yemile and Elliott, Vittoria and Kamin, Jennie and Park, Andrea}, year={2017}} @article{majumder_nguyen_cohn_hswen_mekaru_brownstein_2017, title={Vaccine compliance and the 2016 Arkansas mumps outbreak}, volume={17}, url={http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(17)30122-6/abstract}, DOI={10.1016/s1473-3099(17)30122-6}, number={4}, journal={The Lancet Infectious Diseases}, author={Majumder, Maimuna S and Nguyen, Colleen M and Cohn, Emily L and Hswen, Yulin and Mekaru, Sumiko R and Brownstein, John S}, year={2017}, pages={361–362}} @misc{nield_2018, title={A Dangerous Antibiotic-Resistant Gene Has Spread The World. We Now Know Where It Started}, url={https://www.sciencealert.com/antibiotic-resistant-mcr-1-gene-spreads-worldwide-from-chinese-pig-farms}, journal={ScienceAlert}, author={Nield, David}, year={2018}, month={Mar}} @misc{dockrill_2018, title={We Just Found a Game-Changing Weapon Against Drug-Resistant Superbugs}, url={https://www.sciencealert.com/new-class-antibiotics-kills-superbugs-silencing-deadly-sleeper-cells-persisters-retinoids}, journal={ScienceAlert}, author={Dockrill, Peter}, year={2018}, month={Mar}} @misc{eilperin_sun_2014, title={Leaders urged to strengthen global health security in wake of Ebola epidemic}, url={https://www.washingtonpost.com/national/health-science/leaders-urged-to-strengthen-global-health-security-in-wake-of-ebola-epidemic/2014/09/25/c66f91ca-44bb-11e4-9a15-137aa0153527_story.html?noredirect=on&utm_term=.9e021e859218}, journal={The Washington Post}, publisher={WP Company}, author={Eilperin, Juliet and Sun, Lena H.}, year={2014}, month={Sep}} @misc{sun_2018, title={CDC to cut by 80 percent efforts to prevent global disease outbreak}, url={https://www.washingtonpost.com/news/to-your-health/wp/2018/02/01/cdc-to-cut-by-80-percent-efforts-to-prevent-global-disease-outbreak/?utm_term=.9e021e859218}, journal={The Washington Post}, publisher={WP Company}, author={Sun, Lena H.}, year={2018}, month={Feb}} @misc{cha_sun_2017, title={New Ebola outbreak declared in Democratic Republic of Congo}, url={https://www.washingtonpost.com/news/to-your-health/wp/2017/05/12/new-ebola-outbreak-declared-in-democratic-republic-of-congo/?utm_term=.e0d0fb008e29}, journal={The Washington Post}, publisher={WP Company}, author={Cha, Ariana Eunjung and Sun, Lena H.}, year={2017}, month={May}} @misc{callier_2018, title={Climate change pushes ticks into Canada, bringing lyme disease (and confusion) with them}, url={https://www.motherjones.com/environment/2018/03/climate-change-pushes-ticks-into-canada-bringing-lyme-disease-and-confusion-with-them/}, journal={Mother Jones}, author={Callier, Viviane}, year={2018}, month={Mar}} @misc{loria_2018, title={Bill Gates thinks an infectious disease outbreak could kill 30 million people in the next decade - but the US is cutting efforts to prevent global pandemics}, url={http://www.businessinsider.com/cdc-cutting-global-disease-outbreak-prevention-efforts-pandemic-risk-2018-2?r=US&IR=T}, journal={Business Insider}, publisher={Business Insider}, author={Loria, Kevin}, year={2018}, month={Feb}} @article{mckenna_mcatee_hotez_bryan_jeun_bottazzi_flowers_ward_kraus_mejia_et al._2017, title={Human Intestinal Parasite Burden and Poor Sanitation in Rural Alabama}, volume={97}, url={http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0396?utm_content=buffer20d45&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer}, DOI={10.4269/ajtmh.17-0396}, number={5}, journal={The American Journal of Tropical Medicine and Hygiene}, author={Mckenna, Megan L. and Mcatee, Shannon and Hotez, Peter J. and Bryan, Patricia E. and Jeun, Rebecca and Bottazzi, Maria E. and Flowers, Catherine C. and Ward, Tabitha and Kraus, Jacob and Mejia, Rojelio and et al.}, year={2017}, month={Aug}, pages={1623–1628}} @misc{pesheva_2016, title={Bugs on Screen}, url={https://hms.harvard.edu/news/bugs-screen}, journal={Harvard Medical School}, publisher={Harvard Medical School}, author={Pesheva, Ekaterina}, year={2016}, month={Sep}} @misc{pilkington_2017, title={Hookworm, a disease of extreme poverty, is thriving in the US south. Why?}, url={https://www.theguardian.com/us-news/2017/sep/05/hookworm-lowndes-county-alabama-water-waste-treatment-poverty}, journal={The Guardian}, publisher={Guardian News and Media}, author={Pilkington, Ed}, year={2017}, month={Sep}} @misc{weller_2018, title={Lassa fever: The killer disease with no vaccine}, url={http://www.bbc.com/news/world-africa-43211086}, journal={BBC News}, publisher={BBC}, author={Weller, Charlie}, year={2018}, month={Mar}} @misc{fox-skelly_2017, title={Earth - There are diseases hidden in ice, and they are waking up}, url={http://www.bbc.com/earth/story/20170504-there-are-diseases-hidden-in-ice-and-they-are-waking-up}, journal={BBC}, publisher={BBC}, author={Fox-Skelly, Jasmin}, year={2017}, month={May}} @article{revich_podolnaya_2011, title={Thawing of permafrost may disturb historic cattle burial grounds in East Siberia}, volume={4}, url={https://www.tandfonline.com/doi/full/10.3402/gha.v4i0.8482}, DOI={10.3402/gha.v4i0.8482}, number={1}, journal={Global Health Action}, author={Revich, Boris A. and Podolnaya, Marina A.}, year={2011}, month={Nov}, pages={8482}} @misc{wight_2018, title={Colombia records first measles case in years }, url={https://www.telegraph.co.uk/news/2018/03/18/colombia-records-first-measles-case-years-experts-warn-global/}, journal={The Telegraph}, publisher={Telegraph Media Group}, author={Wight, Andrew}, year={2018}, month={Mar}} @misc{gulland_2018, title={'Super-gonorrhoea' is not the only STI becoming drug resistant}, url={https://www.telegraph.co.uk/news/2018/03/29/super-gonorrhoea-not-sexually-transmitted-infection-becoming/}, journal={The Telegraph}, publisher={Telegraph Media Group}, author={Gulland, Anne}, year={2018}, month={Mar}} @misc{branswell_2017, title={Woman Killed by a Superbug Resistant to Every Available Antibiotic}, url={https://www.scientificamerican.com/article/woman-killed-by-a-superbug-resistant-to-every-available-antibiotic/}, journal={Scientific American}, author={Branswell, Helen}, year={2017}, month={Jan}} @misc{branswell_2018, title={At the UN, superbugs get their day on their world stage}, url={https://www.statnews.com/2016/09/19/antimicrobial-resistance-un/}, journal={STAT}, publisher={STAT}, author={Branswell, Helen}, year={2018}, month={Apr}} @conference{, url = {https://amr-review.org/sites/default/files/160525_Final%20paper_with%20cover.pdf}, year = { 2016 }, booktitle = { Review on Antimicrobial Resistance }, title = { Tackling Drug-Resistant Infections Globally: Final Report and Recommendations }, author = { O’Neill, Jim }, } @misc{santos_2018, title={Aggressive virus subtype behind HIV explosion in the Philippines? | DW | 09.03.2018}, url={http://p.dw.com/p/2u3Uw }, journal={DW.COM}, author={Santos, Ana P}, year={2018}, month={Sep}} @article{jorgensen_madden_swift_arnold_charlett_elviss_2018, title={Antimicrobial Resistance in Campylobacter jejuni and Campylobacter coli from Retail Chilled Chicken in the UK}, url={https://www.food.gov.uk/sites/default/files/fs102121y2report.pdf}, DOI={FS 102121}, journal={Public Health England}, author={Jorgensen, Frieda and Madden, Robert and Swift, Craig and Arnold, Eve and Charlett, Andre and Elviss, Nicola}, year={2018}} @misc{harvey_2018, title={British supermarket chickens show record levels of antibiotic-resistant superbugs}, url={https://www.theguardian.com/environment/2018/jan/15/british-supermarket-chickens-show-record-levels-of-antibiotic-resistant-superbugs}, journal={The Guardian}, publisher={Guardian News and Media}, author={Harvey, Fiona}, year={2018}, month={Jan}} @misc{mozes_2015, title={Head Lice Now Resistant to Common Meds in 25 States}, url={https://health.usnews.com/health-news/articles/2015/08/18/head-lice-now-resistant-to-common-meds-in-25-states}, journal={U.S. News & World Report}, publisher={U.S. News & World Report}, author={Mozes, Alan}, year={2015}, month={Aug}} @article{gellatly_krim_palenchar_shepherd_yoon_rhodes_lee_clark_2016, title={Expansion of the Knockdown Resistance Frequency Map for Human Head Lice (Phthiraptera: Pediculidae) in the United States Using Quantitative Sequencing}, volume={53}, url={https://www.ncbi.nlm.nih.gov/m/pubmed/27032417/?i=4&from=Kyong Yoon permethrin}, DOI={10.1093/jme/tjw023}, number={3}, journal={Journal of Medical Entomology}, author={Gellatly, Kyle J. and Krim, Sarah and Palenchar, Daniel J. and Shepherd, Katie and Yoon, Kyong Sup and Rhodes, Christopher J. and Lee, Si Hyeock and Clark, J. Marshall}, year={2016}, pages={653–659}} @misc{matthews-king_2018, title={Surfers more likely to harbour antibiotic resistant superbugs, study finds}, url={https://www.independent.co.uk/news/health/surfing-ecoli-antibiotic-resistance-food-poisoning-amr-superbug-exeter-university-a8157961.html}, journal={The Independent}, publisher={Independent Digital News and Media}, author={Matthews-King, Alex}, year={2018}, month={Jan}} @misc{editorial staff_2017, title={Colistin-Resistant Bacteria Now Found In Humans, Evolved In Chinese Pigs}, url={https://nationaleconomicseditorial.com/2017/06/13/colistin-resistant-bacteria-chinese-pigs/}, journal={National Economics Editorial}, author={Editorial Staff}, year={2017}, month={Jun}} @misc{cdc_2013, title={Press Release}, url={https://www.cdc.gov/media/releases/2013/p0305_deadly_bacteria.html}, journal={Centers for Disease Control and Prevention}, publisher={Centers for Disease Control and Prevention}, author={CDC}, year={2013}, month={Mar}} @misc{dunn_2011, title={Fly on wall sees things it wishes it hadn't}, url={https://blogs.scientificamerican.com/guest-blog/fly-on-wall-sees-things-it-wishes-it-hadnt//}, journal={Scientific American Blog Network}, author={Dunn, Rob}, year={2011}, month={Oct}} @article{ahmad_ghosh_schal_zurek_2011, title={Insects in confined swine operations carry a large antibiotic resistant and potentially virulent enterococcal community}, volume={11}, url={https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-11-23}, DOI={10.1186/1471-2180-11-23}, number={1}, journal={BMC Microbiology}, author={Ahmad, Aqeel and Ghosh, Anuradha and Schal, Coby and Zurek, Ludek}, year={2011}, month={Jan}, pages={23}} @misc{pulla_2017, title={The Superbugs of Hyderabad}, url={http://www.thehindu.com/opinion/op-ed/the-superbugs-of-hyderabad/article20536685.ece?homepage=true}, journal={The Hindu}, author={Pulla, Priyanka}, year={2017}, month={Nov}} @misc{sample_2013, title={Antibiotic-resistant diseases pose 'apocalyptic' threat, top expert says}, url={https://www.theguardian.com/society/2013/jan/23/antibiotic-resistant-diseases-apocalyptic-threat}, journal={The Guardian}, publisher={Guardian News and Media}, author={Sample, Ian}, year={2013}, month={Jan}} @misc{gma news online_2016, title={Drug-resistant infections could spark financial crisis – study}, url={http://www.gmanetwork.com/news/lifestyle/healthandwellness/582143/drug-resistant-infections-could-spark-financial-crisis-study/story/}, journal={GMA News Online}, publisher={GMA News Online}, author={GMA News Online}, year={2016}, month={Sep}} @article{morse_mazet_woolhouse_parrish_carroll_karesh_zambrana-torrelio_lipkin_daszak_2012, title={Prediction and prevention of the next pandemic zoonosis}, url={http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)61684-5/abstract}, DOI={https://doi.org/10.1016/S0140-6736(12)61684-5}, journal={The Lancet}, author={Morse, Stephen S and Mazet, Joanna AK and Woolhouse, Mark and Parrish, Colin R and Carroll, Dennis and Karesh, William B and Zambrana-Torrelio, Carlos and Lipkin, W Ian and Daszak, Peter}, year={2012}, month={Dec}} @misc{pickover_2017, title={World leaders urged to act on 'post-antibiotic apocalypse' by chief medical officer}, url={https://www.independent.co.uk/life-style/health-and-families/health-news/antibiotics-resistance-apocalypse-warning-chief-medical-officer-professor-dame-sally-davies-drugs-a7996806.html}, journal={The Independent}, publisher={Independent Digital News and Media}, author={Pickover, Ella}, year={2017}, month={Oct}}

Special Thanks: Paula M. Krimer-Rollison

Published