Ryan Clark joins First Take and is puzzled by critics who think the Patriots are the team to beat when the Broncos are not only the defending champions but also have the premiere secondary in the NFL. (2:34)

Our NFL Insiders make their predictions for Week 4: The biggest upsets, fantasy sleepers and busts, the best 3-0 team, bounce-back players, and the 1-2 team that worries them the most.

What's your biggest upset for Week 4?

Matt Bowen, NFL writer: Giants over Vikings. The Vikings' defense is nasty, with speed and versatility all over the field. But Eli Manning and the Giants can create some matchups with their three-WR personnel to generate some big plays. The Giants are getting four points in this one. If Manning protects the ball, New York has a shot to pull the upset on the road.

John Clayton, senior NFL writer: New Orleans over San Diego. The Chargers are taking a lot of injury hits, and they might be vulnerable to the Saints' offense. Plus, this is Drew Brees' return to San Diego, the team that drafted him.

Mike Sando, senior NFL writer: The Jets were brutal at Kansas City, but they could knock off the Seahawks. Todd Bowles knows Seattle well and has defended the Seahawks successfully in the past. The Jets' defensive line matches up favorably, and with Russell Wilson less than 100 percent, Seattle could be vulnerable.