A popular cafe in the inner-west Sydney suburb of Glebe has been gutted by fire.

A nearby resident called emergency services after waking to the smell of smoke about 3.30am today, firefighters said.

Totally destroyed ... Cafe Otto. Credit:Nick Moir

They arrived at Cafe Otto, on Glebe Point Road, near the intersection with Parramatta Road, to find the brick and iron building engulfed in flames.

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