A driver has deliberately run down and killed 17 kangaroos on Brisbane's outskirts.

The RSPCA is appalled by the incident that has left a 100-metre stretch of road at Wacol littered with kangaroo carcasses.

The RSPCA has appealed for witnesses after the 100-metre stretch of road was littered with dead kangaroos. Credit:Bill Vickers/Twitter

The animals were discovered on Monday morning, between the women's and men's prisons.

RSPCA spokesman Michael Beatty said many of the roos were young.