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The FBI and the Justice Department’s inspector general’s office will investigate how Jeffrey Epstein died in an apparent suicide Saturday, while the probe into sexual abuse allegations against the well-connected financier remains ongoing, officials said.

Epstein, accused of orchestrating a sex-trafficking ring and sexually abusing dozens of underage girls, had been taken off suicide watch before he killed himself in a New York jail, a person familiar with the matter said.

Attorney General William Barr, in announcing the investigation, said he was “appalled” to learn of Epstein’s death while in federal custody.

“Mr. Epstein’s death raises serious questions that must be answered,” Barr said in a statement.

Epstein was found unresponsive in his cell Saturday morning at the Metropolitan Correctional Center, according to the Federal Bureau of Prisons. Fire officials received a call at 6:39 a.m. Saturday that Epstein was in cardiac arrest, and he was pronounced dead at New York Presbyterian-Lower Manhattan Hospital.

Epstein, 66, had been denied bail and faced up to 45 years behind bars on federal sex trafficking and conspiracy charges unsealed last month. He had pleaded not guilty and was awaiting trial.

The federal investigation into the allegations remains steadfast, U.S. Attorney Geoffrey Berman said. He noted in a statement Saturday that the indictment against Epstein includes a conspiracy charge, suggesting others could face charges in the case.

Epstein had been placed on suicide watch and given daily psychiatric evaluations after an incident a little over two weeks ago in which he was found with bruising on his neck, according to the person familiar with the matter who wasn’t authorized to discuss it publicly. It hasn’t been confirmed whether the injury was self-inflicted or the result of an assault.

Epstein was taken off suicide watch at the end of July, the person said.

The Bureau of Prisons confirmed that he had been housed in the jail’s Special Housing Unit, a heavily secured part of the facility that separates high-profile inmates from the general population. Until recently, the same unit had been home to the Mexican drug lord Joaquin “El Chapo” Guzman, who is now serving a life sentence at the so-called Supermax prison in Colorado.

Epstein’s death raises questions about how the Bureau of Prisons ensures the welfare of such high-profile inmates. In October, Boston gangster James “Whitey” Bulger was killed in a federal prison in West Virginia where had just been transferred.

Nebraska Sen. Ben Sasse, a Republican member of the Senate Judiciary Committee, wrote Saturday in a scathing letter to Barr that “heads must roll” after the incident.

“Every single person in the Justice Department — from your Main Justice headquarters staff all the way to the night-shift jailer — knew that this man was a suicide risk, and that his dark secrets couldn’t be allowed to die with him,” Sasse wrote.

Cameron Lindsay, a former warden who ran three federal lockups, said the death represents “an unfortunate and shocking failure, if proven to be a suicide.”

“Unequivocally, he should have been on active suicide watch and therefore under direct and constant supervision,” Lindsay said.

Epstein’s removal from suicide watch would have been approved by both the warden of the jail and the facility’s chief psychologist, said Jack Donson, a former prison official who worked for the Bureau of Prisons for more than two decades.

An attorney for Jeffrey Epstein, Marc Fernich, said in a statement that jailers at the Metropolitan Correctional Center failed to protect Epstein and to prevent the “calamity” of his death.

Fernich also said that reporters, plaintiffs’ lawyers and court officials “should be ashamed of their behavior” following Epstein’s indictment. He said Epstein had “long since paid his debt to society” for his crimes.

Epstein’s arrest last month launched separate investigations into how authorities handled his case initially when similar charges were first brought against him in Florida more than a decade ago. U.S. Labor Secretary Alexander Acosta resigned last month after coming under fire for overseeing that deal when he was U.S. attorney in Miami.

On Friday, more than 2,000 pages of documents were released related to a since-settled lawsuit against Epstein’s ex-girlfriend by Virginia Giuffre, one of Epstein’s accusers. The records contain graphic allegations against Epstein, as well as the transcript of a 2016 deposition of Epstein in which he repeatedly refused to answer questions to avoid incriminating himself.

Sigrid McCawley, Giuffre’s attorney, said Epstein’s suicide less than 24 hours after the documents were unsealed “is no coincidence.” McCawley urged authorities to continue their investigation, focusing on Epstein associates who she said “participated and facilitated Epstein’s horrifying sex trafficking scheme.”

Other accusers and their lawyers reacted to the news with frustration that the financier won’t have to face them in court.

“We have to live with the scars of his actions for the rest of our lives, while he will never face the consequences of the crimes he committed the pain and trauma he caused so many people,” accuser Jennifer Araoz said in a statement.

Brad Edwards, a Florida lawyer for nearly two dozen other accusers, said that “this is not the ending anyone was looking for.”

“The victims deserved to see Epstein held accountable, and he owed it to everyone he hurt to accept responsibility for all of the pain he caused,” Edwards said in a statement.

Epstein’s arrest drew national attention, particularly focusing on a deal that allowed Epstein to plead guilty in 2008 to soliciting a minor for prostitution in Florida and avoid more serious federal charges.

Federal prosecutors in New York reopened the probe after investigative reporting by The Miami Herald stirred outrage over that plea bargain.

His lawyers maintained that the new charges in New York were covered by the 2008 plea deal and that Epstein hadn’t had any illicit contact with underage girls since serving his 13-month sentence in Florida.

Before his legal troubles, Epstein led a life of extraordinary luxury that drew powerful people into his orbit. He socialized with princes and presidents and lived on a 100-acre private Caribbean island and one of the biggest mansions in New York.

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