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Quinine occurs naturally in the bark of the cinchona tree, native to South America. South American natives discovered the health properties from the bark of this treee hundreds of years in the past. Malaria was what was treated with the bark. In the 17th Century, Europeans learned of the use of cinchone and brought it to the old world. Quinine has proven effective to stop the spread of the malaria virus. Off label use of Quinine for leg cramps has become very prevalent. Do not use quinine for off label use unless specifically directed by your doctor. Quinine can have serious side effects in some individuals. Quinine should only be used under the supervision of a physician with the patient being fully informed of the quinine risks and benefits.