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Ben Stiller and Christine Taylor are heading their separate ways.

The couple, who married in May 2000 after meeting on the set of a TV pilot called “Heat Vision and Jack,” have decided to split after being married 17 years, Entertainment Tonight first reported.

“With tremendous love and respect for each other, and the 18 years we spent together as a couple, we have made the decision to separate,” Stiller and Taylor said in a statement released to Page Six. “Our priority will continue to be raising our children as devoted parents and the closest of friends. We kindly ask that the media respect our privacy at this time.”

The couple has two kids together Ella Olivia, 15, and Quinlin Dempsey, 11.

They’ve shared the big screen together in “Dodgeball,” “Tropic Thunder,” “Zoolander,” and “Zoolander 2.”