A Gold Coast high school has had to call paramedics three times in one day after four girls became ill from an unknown prescription drug.

It’s not known if the Southport State high school girls took the drug together or at different times throughout the day.

The first call to Queensland Ambulance Service was at 8.30am on Friday when one girl fell ill.

By 12.15 pm paramedics had returned to the school after two other girls became sick.

The final call came at 1.30pm when the fourth girl fell ill, a Queensland Ambulance Service spokesman said.

The girls, all in their mid-teens, were taken to Gold Coast University hospital in a stable condition. One has since been released.

A school-based police officer attended the scene but no investigation had commenced into the incident, a police spokesman said.

The Southport State high school had been contacted for comment.