At the 2012 election, independent U.S. Senators were elected from Maine and Vermont. Also in the 2012 election, no New England state elected any Republican to the U.S. Senate. This is the first time in the history of direct elections for U.S. Senate that the Republican Party did not win a single U.S. Senate election in any New England state. No Republican nominee for U.S. Senate was elected in any eastern state this year.

In the entire nation, out of 33 U.S. Senate seats, the Republican Party only won eight U.S. Senate seats. This is the lowest number of U.S. Senate seats either major party has won since 1964, when Republicans only won seven seats.