South Sydney chief executive John Lee has called for an urgent review of the NRL's new shoulder charge interpretation as Rabbitohs hooker Issac Luke prepares to become a test case by contesting his charge at Wednesday night's judiciary.

Luke, who will plead guilty to a separate dangerous-throw charge, faces a three-match ban if unsuccessful but would miss only Friday night's clash with Canterbury if he successfully challenges the grade-one shoulder charge for his collision with North Queensland playmaker Johnathan Thurston last Thursday night.

Souths five-eighth Luke Keary has also been ruled out of the match against the Bulldogs after reluctantly pleading guilty to a grade-one shoulder charge on Cowboys winger Justin O'Neill.

The charges against the Rabbitohs pair follow a two-match suspension imposed on Manly prop Willie Mason last week after the NRL changed the wording of what constitutes a shoulder charge under the judiciary code following concerns that the match review committee did not have the grounds to charge Sydney Roosters forward Kane Evans.