We owe our flexibility to the lubricated joints that connect the bones of our body. Unfortunately, these joints tend to deteriorate over time, leading to a condition called osteoarthritis that affects millions of people.

Scientists had thought that lubricated joints first evolved when backboned animals started walking on land, with fish lacking these types of joints. However, by studying zebrafish, Askary, Smeeton et al. now show that fish do have lubricated joints; in fact, the joints in the jaw and fins of zebrafish have a similar structure to those in humans. These zebrafish joints make an important protein called Lubricin that is known to lubricate joints in mice and humans. Furthermore, analyzing two other fish species – a stickleback and a primitive fish called a spotted gar – revealed that fish joints in general produce Lubricin. This pushes back the evolutionary origins of lubricated joints millions of years, to at least the common ancestor of all backboned animals.

Next, Askary, Smeeton et al. used a new type of molecular scissors to eliminate the ability of zebrafish to produce Lubricin. These mutant fish developed the same early onset arthritis as mice and humans that lack Lubricin. Studying such fish should allow new approaches to be developed that will help us to understand how debilitating joint diseases progress. As zebrafish are highly regenerative, future studies could also explore whether they can regenerate damaged joints, which could spur new strategies for treating and reversing arthritis.