Mike Baird is set to become the first NSW premier to visit Israel when he leads a trade delegation there next week.

The premier says innovation, cyber security and medical and financial technologies will be the focus of the week-long visit, which will include stops in Jerusalem, Tel Aviv and the West Bank.

"Israel is known as start-up nation for good reason, and, as we prepare to launch our own innovation strategy later this year, there can be no better time to study the successful Israeli model for nurturing new ideas and encouraging innovation and entrepreneurship," Mr Baird said in a statement on Tuesday.

Medical marijuana research will be another focus for the trade delegation which includes medicinal cannabis campaigner Lucy Haslam and NSW Police Commissioner Andrew Scipione.

The premier will also meet with Palestinian leadership when he visits the West Bank.