The Liberal National Party has lashed out at "gutless" vandals who defaced its Brisbane headquarters under cover of night.

Spraying the office at Spring Hill in red and blue paint, they scrawled "RESIST!" in blue across the front pavement.

In the video above: Peter Dutton's office smashed by vandals last year

LNP state opposition leader Deb Frecklington savaged the "gutless" attack as a "disgusting act".

"This isn't a way to settle your political differences, by wrecking someone's building, by splashing paint around," she told 7NEWS.

"These people really need to find something better to do."

The vandals sprayed "RESIST!" on the footpath. Credit: LNP

It is not known who vandalised the LNP's office on Bowen Street.

The phrase "the resistance" has been popularised in the United States by left-wing activists opposed to president Donald Trump.

Labor cabinet minister Mark Bailey says the incident is “very disappointing”.

“This kind of vandalism has no place in politics or our community and I hope they catch those responsible,” he says.

Vandals have hurled pavers at Peter Dutton's Brisbane office, causing extensive damage to its glass front in August last year. Credit: Darren England / AAP

The Brisbane office of one of the LNP's most prominent Queensland politicians, Peter Dutton, was attacked last year ahead of his leadership challenge to Malcolm Turnbull.

In May this year, vandals targeted South Australian Liberal MP Nicolle Flint's office with slurs including "skank" and suggesting she could be paid for sex.

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Labor MPs have also been targeted.

Retiring Melbourne Labor MP Michael Danby, a stalwart supporter of Israel, saw his office vandalised by critics of the Jewish state in 2018.

In 2015, another prominent Labor politician, Mark Dreyfus, was targeted with graffiti that read "human rights matter".