1 Skeaff , CM & Miller , J ( 2009 ) Dietary fat and coronary heart disease: summary of evidence from prospective cohort and randomised controlled trials . Ann Nutr Metab 55 , 173 – 201 .

2 Kris-Etherton , PM , Harris , WS & Appel , LJ ( 2003 ) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease . Arterioscler Thromb Vasc Biol 23 , 20 – 30 .

3 Lichtenstein , AH , Appel , LJ , Brands , M , et al. ( 2006 ) Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006 . Arterioscler Thromb Vasc Biol 26 , 2186 – 2191 .

4 van Kuijk , FJ , Holte , LL & Dratz , EA ( 1990 ) 4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid . Biochim Biophys Acta 1043 , 116 – 118 .

5 Olsen , E , Vogt , G , Saarem , K , et al. ( 2005 ) Autoxidation of cod liver oil with tocopherol and ascorbyl palmitate . JAOCS 82 , 97 – 103 .

6 Pryor , WA & Porter , NA ( 1990 ) Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids . Free Radic Biol Med 8 , 541 – 543 .

7 Yin , H , Brooks , JD , Gao , L , et al. ( 2007 ) Identification of novel autoxidation products of the omega-3 fatty acid eicosapentaenoic acid in vitro and in vivo . J Biol Chem 282 , 29890 – 29901 .

8 Esterbauer , H , Schaur , RJ & Zollner , H ( 1991 ) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes . Free Radic Biol Med 11 , 81 – 128 .

9 Council of Europe ( 2008 ) European Pharmacopoeia , 6th ed. . Strasbourg : Council of Europe .

10 Luley , C , Klein , B , Hanisch , M , et al. ( 1988 ) Fatty acid composition and degree of peroxidation in fish oil and cod liver oil preparations . Arzneimittelforschung 38 , 1783 – 1786 .

11 Shukla , VK & Perkins , EG ( 1991 ) The presence of oxidative polymeric materials in encapsulated fish oils . Lipids 26 , 23 – 26 .

12 Fierens , C & Corthout , J ( 2007 ) Omega-3 fatty acid preparations – a comparative study . J Pharm Belg 62 , 115 – 119 .

13 Kolanowski , W ( 2010 ) Omega-3 LC PUFA contents and oxidative stability of encapsulated fish oil dietary supplements . Int J Food Prop 13 , 498 – 511 .

14 Halliwell , B & Chirico , S ( 1993 ) Lipid peroxidation: its mechanism, measurement, and significance . Am J Clin Nutr 57 , 715S – 724S .

15 Blomhoff , R ( 2005 ) Dietary antioxidants and cardiovascular disease . Curr Opin Lipidol 16 , 47 – 54 .

16 Aw , TY ( 2005 ) Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility . Toxicol Appl Pharmacol 204 , 320 – 328 .

17 Wingler , K , Muller , C , Schmehl , K , et al. ( 2000 ) Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells . Gastroenterology 119 , 420 – 430 .

18 Dickinson , DA & Forman , HJ ( 2002 ) Cellular glutathione and thiols metabolism . Biochem Pharmacol 64 , 1019 – 1026 .

19 Ursini , F , Zamburlini , A , Cazzolato , G , et al. ( 1998 ) Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis . Free Radic Biol Med 25 , 250 – 252 .

20 Staprans , I , Pan , XM , Rapp , JH , et al. ( 2005 ) The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis . Mol Nutr Food Res 49 , 1075 – 1082 .

21 Cohn , JS ( 2002 ) Oxidized fat in the diet, postprandial lipaemia and cardiovascular disease . Curr Opin Lipidol 13 , 19 – 24 .

22 Bowen , PE & Borthakur , G ( 2004 ) Postprandial lipid oxidation and cardiovascular disease risk . Curr Atheroscler Rep 6 , 477 – 484 .

23 Guichardant , M & Lagarde , M ( 2009 ) Analysis of biomarkers from lipid peroxidation: a comparative study . Eur J Lipid Sci Technol 111 , 75 – 82 .

24 Montuschi , P , Barnes , PJ & Roberts , LJ ( 2004 ) Isoprostanes: markers and mediators of oxidative stress . FASEB J 18 , 1791 – 1800 .

25 Minuz , P , Fava , C & Lechi , A ( 2006 ) Lipid peroxidation, isoprostanes and vascular damage . Pharmacol Rep 58 , 57 – 68 .

26 Pratico , D , Rokach , J , Lawson , J , et al. ( 2004 ) F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases . Chem Phys Lipids 128 , 165 – 171 .

27 Pearson , TA , Mensah , GA , Alexander , RW , et al. ( 2003 ) Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association . Circulation 107 , 499 – 511 .

28 Roberts , LJ & Morrow , JD ( 2000 ) Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo . Free Radic Biol Med 28 , 505 – 513 .

29 Basu , S ( 2008 ) F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications . Antioxid Redox Signal 10 , 1405 – 1434 .

30 Myhrstad , MC , Retterstol , K , Telle-Hansen , VH , et al. ( 2011 ) Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors . Inflamm Res 60 , 309 – 319 .

31 Basu , A , Devaraj , S & Jialal , I ( 2006 ) Dietary factors that promote or retard inflammation . Arterioscler Thromb Vasc Biol 26 , 995 – 1001 .

32 Higdon , JV , Liu , J , Du , SH , et al. ( 2000 ) Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes . Am J Clin Nutr 72 , 714 – 722 .

33 Mori , TA ( 2004 ) Effect of fish and fish oil-derived omega-3 fatty acids on lipid oxidation . Redox Rep 9 , 193 – 197 .

34 Nalsen , C , Vessby , B , Berglund , L , et al. ( 2006 ) Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans . J Nutr 136 , 1222 – 1228 .

35 Long , EK & Picklo , MJ Sr ( 2010 ) trans-4-Hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: make some room HNE . Free Radic Biol Med 49 , 1 – 8 .

36 Draper , HH , Csallany , AS & Hadley , M ( 2000 ) Urinary aldehydes as indicators of lipid peroxidation in vivo . Free Radic Biol Med 29 , 1071 – 1077 .

37 Zarkovic , N ( 2003 ) 4-Hydroxynonenal as a bioactive marker of pathophysiological processes . Mol Aspects Med 24 , 281 – 291 .

38 Guichardant , M , Bacot , S , Moliere , P , et al. ( 2006 ) Hydroxy-alkenals from the peroxidation of n-3 and n-6 fatty acids and urinary metabolites . Prostaglandins Leukot Essent Fatty Acids 75 , 179 – 182 .

39 Kitase , A , Hino , K , Furutani , T , et al. ( 2005 ) In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis . J Gastroenterol 40 , 617 – 624 .

40 Yamada , S , Funada , T , Shibata , N , et al. ( 2004 ) Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids . J Lipid Res 45 , 626 – 634 .

41 Calzada , C , Colas , R , Guillot , N , et al. ( 2010 ) Subgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy men . Atherosclerosis 208 , 467 – 472 .

42 Spickett , CM , Wiswedel , I , Siems , W , et al. ( 2010 ) Advances in methods for the determination of biologically relevant lipid peroxidation products . Free Radic Res 44 , 1172 – 1202 .

43 Turner , R , McLean , CH & Silvers , KM ( 2006 ) Are the health benefits of fish oils limited by products of oxidation? Nutr Res Rev 19 , 53 – 62 .

44 Bays , HE ( 2007 ) Safety considerations with omega-3 fatty acid therapy . Am J Cardiol 99 , 35C – 43C .

45 European Food Safety Authority ( 2010 ) Scientific opinion on fish oil for human consumption. Food hygene, including rancidity . EFSA J 8 , 1874 .

46 Maenpaa , H , Heinonen , OP & Manninen , V ( 1991 ) Medication compliance and serum lipid changes in the Helsinki Heart Study . Br J Clin Pharmacol 32 , 409 – 415 .

47 Bohn , SK , Smeland , S , Sakhi , AK , et al. ( 2006 ) Post-radiotherapy plasma total glutathione is associated to outcome in patients with head and neck squamous cell carcinoma . Cancer Lett 238 , 240 – 247 .

48 Bastani , NE , Gundersen , TE & Blomhoff , R ( 2009 ) Determination of 8-epi PGF(2alpha) concentrations as a biomarker of oxidative stress using triple-stage liquid chromatography/tandem mass spectrometry . Rapid Commun Mass Spectrom 23 , 2885 – 2890 .

49 Luo , XP , Yazdanpanah , M , Bhooi , N , et al. ( 1995 ) Determination of aldehydes and other lipid peroxidation products in biological samples by gas chromatography–mass spectrometry . Anal Biochem 228 , 294 – 298 .

50 Panfili , G , Fratianni , A & Irano , M ( 2003 ) Normal phase high-performance liquid chromatography method for the determination of tocopherols and tocotrienols in cereals . J Agric Food Chem 51 , 3940 – 3944 .

51 Wheeler , CR , Salzman , JA , Elsayed , NM , et al. ( 1990 ) Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity . Anal Biochem 184 , 193 – 199 .

52 Bligh , EG & Dyer , WJ ( 1959 ) A rapid method of total lipid extraction and purification . Can J Biochem Physiol 37 , 911 – 917 .

53 Olsen , E , Vogt , G , Veberg , A , et al. ( 2005 ) Analysis of early lipid oxidation in smoked, comminuted pork or poultry sausages with spices . J Agric Food Chem 53 , 7448 – 7457 .

54 Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico ( 1999 ) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial . Lancet 354 , 447 – 455 .

55 Yokoyama , M , Origasa , H , Matsuzaki , M , et al. ( 2007 ) Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis . Lancet 369 , 1090 – 1098 .

56 Meydani , M , Natiello , F , Goldin , B , et al. ( 1991 ) Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women . J Nutr 121 , 484 – 491 .

57 Harats , D , Dabach , Y , Hollander , G , et al. ( 1991 ) Fish oil ingestion in smokers and nonsmokers enhances peroxidation of plasma lipoproteins . Atherosclerosis 90 , 127 – 139 .

58 Tholstrup , T , Hellgren , LI , Petersen , M , et al. ( 2004 ) A solid dietary fat containing fish oil redistributes lipoprotein subclasses without increasing oxidative stress in men . J Nutr 134 , 1051 – 1057 .

59 Ulven , SM , Kirkhus , B , Lamglait , A , et al. ( 2011 ) Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers . Lipids 46 , 37 – 46 .

60 Balk , EM , Lichtenstein , AH , Chung , M , et al. ( 2006 ) Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review . Atherosclerosis 189 , 19 – 30 .

61 Freese , R , Dragsted , LO , Loft , S , et al. ( 2008 ) No effect on oxidative stress biomarkers by modified intakes of polyunsaturated fatty acids or vegetables and fruit . Eur J Clin Nutr 62 , 1151 – 1153 .

62 Ravn-Haren , G , Bugel , S , Krath , BN , et al. ( 2008 ) A short-term intervention trial with selenate, selenium-enriched yeast and selenium-enriched milk: effects on oxidative defence regulation . Br J Nutr 99 , 883 – 892 .

63 Miyamoto , Y , Koh , YH , Park , YS , et al. ( 2003 ) Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses . Biol Chem 384 , 567 – 574 .

64 Awasthi , YC , Yang , Y , Tiwari , NK , et al. ( 2004 ) Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases . Free Radic Biol Med 37 , 607 – 619 .

65 Mabile , L , Piolot , A , Boulet , L , et al. ( 2001 ) Moderate intake of n-3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjects . Am J Clin Nutr 74 , 449 – 456 .

66 Bouzidi , N , Mekki , K , Boukaddoum , A , et al. ( 2010 ) Effects of omega-3 polyunsaturated fatty-acid supplementation on redox status in chronic renal failure patients with dyslipidemia . J Ren Nutr 20 , 321 – 328 .

67 Barbosa , DS , Cecchini , R , El Kadri , MZ , et al. ( 2003 ) Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids . Nutrition 19 , 837 – 842 .

68 Kesavulu , MM , Kameswararao , B , Apparao , C , et al. ( 2002 ) Effect of omega-3 fatty acids on lipid peroxidation and antioxidant enzyme status in type 2 diabetic patients . Diabetes Metab 28 , 20 – 26 .

69 Kesavulu , MM , Rao , BK , Giri , R , et al. ( 2001 ) Lipid peroxidation and antioxidant enzyme status in type 2 diabetics with coronary heart disease . Diabetes Res Clin Pract 53 , 33 – 39 .

70 Cao , J , Schwichtenberg , KA , Hanson , NQ , et al. ( 2006 ) Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids . Clin Chem 52 , 2265 – 2272 .

71 Flaten , H , Hostmark , AT , Kierulf , P , et al. ( 1990 ) Fish-oil concentrate: effects on variables related to cardiovascular disease . Am J Clin Nutr 52 , 300 – 306 .

72 Harris , WS & Von , SC ( 2004 ) The omega-3 index: a new risk factor for death from coronary heart disease? Prev Med 39 , 212 – 220 .

73 Wingler , K & Brigelius-Flohe , R ( 1999 ) Gastrointestinal glutathione peroxidase . Biofactors 10 , 245 – 249 .

74 Chu , FF , Esworthy , RS & Doroshow , JH ( 2004 ) Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer . Free Radic Biol Med 36 , 1481 – 1495 .

75 Kanazawa , K & Ashida , H ( 1998 ) Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body . Biochim Biophys Acta 1393 , 349 – 361 .

76 Bull , AW & Bronstein , JC ( 1990 ) Production of unsaturated carbonyl compounds during metabolism of hydroperoxy fatty acids by colonic homogenates . Carcinogenesis 11 , 1699 – 1704 .

77 Naruszewicz , M , Wozny , E , Mirkiewicz , E , et al. ( 1987 ) The effect of thermally oxidized soya bean oil on metabolism of chylomicrons. Increased uptake and degradation of oxidized chylomicrons in cultured mouse macrophages . Atherosclerosis 66 , 45 – 53 .

78 Staprans , I , Rapp , JH , Pan , XM , et al. ( 1994 ) Oxidized lipids in the diet are a source of oxidized lipid in chylomicrons of human serum . Arterioscler Thromb 14 , 1900 – 1905 .

79 Staprans , I , Hardman , DA , Pan , XM , et al. ( 1999 ) Effect of oxidized lipids in the diet on oxidized lipid levels in postprandial serum chylomicrons of diabetic patients . Diabetes Care 22 , 300 – 306 .

80 Wallace , AJ , Sutherland , WH , Mann , JI , et al. ( 2001 ) The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes . Eur J Clin Nutr 55 , 951 – 958 .

81 Sutherland , WH , de Jong , SA , Walker , RJ , et al. ( 2002 ) Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men . Atherosclerosis 160 , 195 – 203 .

82 Sutherland , WH , de Jong , SA , Hessian , PA , et al. ( 2010 ) Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles . Metabolism 59 , 446 – 453 .

83 Wallace , JM , McCabe , AJ , Robson , PJ , et al. ( 2000 ) Bioavailability of n-3 polyunsaturated fatty acids (PUFA) in foods enriched with microencapsulated fish oil . Ann Nutr Metab 44 , 157 – 162 .

84 Suomela , JP , Ahotupa , M & Kallio , H ( 2005 ) Triacylglycerol oxidation in pig lipoproteins after a diet rich in oxidized sunflower seed oil . Lipids 40 , 437 – 444 .

85 Suomela , JP , Ahotupa , M , Sjovall , O , et al. ( 2004 ) Diet and lipoprotein oxidation: analysis of oxidized triacylglycerols in pig lipoproteins . Lipids 39 , 639 – 647 .