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Eleven countries signed a landmark Asia-Pacific trade agreement in Santiago on Thursday, as an antidote to the increasingly protectionist bent of the United States, which last year pulled out of the pact.

Canada has signed over 30 side letters with its #CPTPP partners. Read them all here: https://t.co/Uftke6ghaK pic.twitter.com/d4iA9Bx8RQ — Canada Trade (@CanadaTrade) March 8, 2018

The signing ceremony came the day after Europe and the International Monetary Fund urged U.S. President Donald Trump to step back from the brink of a trade war sparked by plans to slap duties on steel and aluminum imports.

READ MORE: TPP details released, new trade deal likely to hurt NAFTA negotiations

The Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) will reduce tariffs in countries that together amount to more than 13 per cent of the global economy – a total of $10 trillion. With the United States, it would have represented 40 per cent.

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Even without the United States, the deal will span a market of nearly 500 million people, making it one of the globe’s three largest trade agreements, according to Chilean and Canadian trade statistics.

WATCH: Winners and losers in Trans-Pacific Partnership deal.

The original 12-member agreement, known as the Trans-Pacific Partnership (TPP), was thrown into limbo early last year when Trump withdrew from the deal just three days after his inauguration in a bid to protect U.S. jobs.

The 11 remaining nations, led by Japan and Canada, finalized a revised trade pact in January.

WATCH: Canada reaches agreement on revised Trans-Pacific Partnership trade pact

1:06 Canada reaches agreement on revised Trans-Pacific Partnership trade pact Canada reaches agreement on revised Trans-Pacific Partnership trade pact

Trump has also threatened to dump the North American Free Trade Agreement unless the other two members of the pact, Canada and Mexico, agree to provisions that Trump says would boost U.S. manufacturing and employment. He argues that the 1994 accord has caused the migration of jobs and factories southward to lower-cost Mexico.

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READ MORE: Auto industry skeptical of Canadian TPP side deal on vehicles with Japan

The revised agreement eliminates some requirements of the original TPP demanded by U.S. negotiators. Those include rules ramping up intellectual property protection of pharmaceuticals, which governments and activists of other member nations worried would raise the costs of medicine.

The final version of the agreement was released in New Zealand on Feb. 21.

WATCH: Trans-Pacific partnership may impact medication prices

In January, Trump told the World Economic Forum in Switzerland that it was possible Washington might return to the pact if it got a better deal. However, New Zealand’s trade minister said that was unlikely in the near term, while Japan has said altering the agreement now would be very difficult.

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The 11 member countries are Australia, Brunei, Canada, Chile, Japan, Malaysia, Mexico, New Zealand, Peru, Singapore and Vietnam.