A 6-year research project identifies 63 gene changes that could help to indicate an increased risk of prostate cancer in certain men.

Share on Pinterest New findings will help to identify those who need earlier prostate cancer screening.

The study was conducted at Case Western Reserve University School of Medicine in Cleveland, OH, and the results are now published Nature Genetics.

Cancer epidemiology researcher Frederick R. Schumacher, Ph.D., led an international team comprising over 100 researchers.

These genetic markers might make it easier to determine the necessity, as well as the rate, of regular prostate cancer screenings.

Genetic markers — also known as single nucleotide polymorphisms (SNPs) — are detected at the DNA level. These are not only linked with prostate cancer, but they can also serve as a signal to doctors that someone could have a greater risk of developing any number of specific diseases.

Before this study, around 100 SNPs had been identified that could be linked with a raised prostate cancer risk. These recent findings increase the known prostate cancer genetic markers by more than 50 percent.

Schumacher and colleagues examined the DNA sequences of around 140,000 men of European descent, including data from previous studies. Around 80,000 of these men had prostate cancer, while the other 60,000 had no evidence of the disease.

With these data, they were able to identify 63 new genetic markers in those with prostate cancer — markers that did not appear in the DNA of men without the disease.

“Our findings will allow us to identify which men should have early and regular PSA screenings and these findings may eventually inform treatment decisions,” says Schumacher.

He also notes that this “genetic score” might be an important factor that doctors consider when approaching prostate cancer treatment, as well.

The researchers say that there are between 500 and 1,000 genetic markers that could be linked with prostate cancer. Schumacher notes that they do not need to map them all, though.

He estimates that they only need to know around 10–20 percent to make recommendations for screening guidelines.