POSSIBLE DRUG INTERACTIONS SUMMARY Venlafaxine

SUBSTANCE TYPE DESCRIPTION SYMPTOMS CONFIDENCE REFS

Amphetamine Dangerous Single case report of a 32 year old man prescribed both amphetamine (5 mg x 3 per day) and venlafaxine (150 mg x 1 per day) who presented with "marked agitation, anxiety, shivering and tremor". anxiety, shivering, tremor, serotonin syndrome Tentative

Case Report Prior 2002



Cannabis Life-Threatening Erowid experience report of a man prescribed venlafaxine who experienced tachycardia, arrhythmia, and seizures when he smoked cannabis and then took his normal dose of venlafaxine. Others have reported no such dangerous interaction. tachycardia, arrhythmia, seizure Conflicting

Exp Report Erowid 2003

Erowid 2004

Erowid 2005

Erowid 2012



Salvia divinorum Life-Threatening Erowid received a report of a man prescribed venlafaxine who experienced two seizure-like episodes on the two occasions that he tried to smoke Salvia divinorum. seizure-like Tentative

Exp Report Erowid interactions form, Nov 2005, by PR

Lithium Dangerous Single case report of 50 year old woman prescribed both lithium and venlafaxine who was reported to have experienced serotonin syndrome. serotonin syndrome Tentative

Case Report Mekler 1997



Metoclopramide Dangerous Single case report of 32 year old woman prescribed venlafaxine and administered metoclopramide in a hospital after an injury. She "developed movement disorder and a period of unresponsiveness. After a second dose of metoclopramide, these symptoms recurred and were associated with confusion, agitation, fever, diaphoresis, tachypnea, tachycardia, and hypertension." tachycardia, confusion, hypertension, serotonin syndrome Tentative

Case Report Fisher 2002



Phenelzine

(MAOI) Life-Threatening Several case reports of potentially dangerous interactions. One case report of 44 year-old woman who accidentally ingested phenelzine with venlafaxine and was admitted to an emergency department with lower extremity tremors and rapid respiration where she was diagnosed with serotonin syndrome. Other case reports involve patients who experienced serotonin syndrome while transitioning from phenelzine to venlafaxine. anxiety, tremors, rapid respiration, serotonin syndrome Credible

Case Reports Weiner LA

Diamond 1998



Propafenone Dangerous Single case report of patient treated for bipolar affective disorder in which venlafaxine given with propafenone caused "markedly increased serum levels of venlafaxine correlating with unexpected psychopathological changes." psychosis Tentative

Case Report Pfeffer 2001



Tranylcypromine Life-Threatening Single case report of 60 year-old woman who accidentally ingested venlafaxine while on a chronic prescription of tranylcypromine and experienced "altered mental status that progressed to hyperthermia and coma. She recovered quickly and without complications." hyperthermia, coma Tentative

Case Report Hodgman 1997



Trimipramine Life-Threatening Single case report of 25 year-old woman on 150 mg per day of venlaxine and 100 mg per day of trimipramine hospitalized when seizures occured. Both drugs were discontinued and seizures stopped and did not recur. seizures Tentative

Case Report Schlienger 2000

