Comedian Rosie O'Donnell tore into House Speaker Paul Ryan Paul Davis RyanKenosha will be a good bellwether in 2020 At indoor rally, Pence says election runs through Wisconsin Juan Williams: Breaking down the debates MORE (R-Wis.) in a tweet on Monday, telling him he would go "straight to hell" and dubbing him a "fake alter boy."

"Paul Ryan - don't talk about Jesus after what u just did to our nation - u will go straight to hell u screwed up fake altar boy," O'Donnell said in the Christmas Day tweet, adding the hashtag "Judas Much."

paul ryan - don't talk about Jesus after what u just did to our nation - u will go straight to hell u screwed up fake altar boy #JUDASmuch https://t.co/gJ8VreyxAX — ROSIE (@Rosie) December 25, 2017

O'Donnell's comment appeared to be in response to a tweet from the speaker on Saturday, which included a video message from Ryan, who is a practicing Roman Catholic.

“At the end of each year, no matter how short — or long — it may feel, there is always Christmas. Waiting for us is that sense of wonder the shepherds felt when the angels appeared in the night sky to herald the birth of a Savior.”

At the end of each year, no matter how short—or long—it may feel, there is always Christmas. Waiting for us is that sense of wonder the shepherds felt when the angels appeared in the night sky to herald the birth of a Savior. pic.twitter.com/oFdj7EIyzS — Paul Ryan (@SpeakerRyan) December 23, 2017

The comedian's attack on the House speaker comes after congressional Republicans and President Trump Donald John TrumpSteele Dossier sub-source was subject of FBI counterintelligence probe Pelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Trump 'no longer angry' at Romney because of Supreme Court stance MORE scored their first legislative victory with a massive tax-cut bill.

The Hill has reached out to Ryan's office for comment.