Entertainer Seth MacFarlane warned against a potential presidential race between President Trump Donald John TrumpObama calls on Senate not to fill Ginsburg's vacancy until after election Planned Parenthood: 'The fate of our rights' depends on Ginsburg replacement Progressive group to spend M in ad campaign on Supreme Court vacancy MORE and Oprah Winfrey, calling the idea "troublingly dystopian."

"Oprah is beyond doubt a magnificent orator. But the idea of a reality show star running against a talk show host is troublingly dystopian," tweeted MacFarlane, the creator of the TV series "Family Guy."

"We don’t want to create a world where dedicated public service careers become undesirable and impractical in the face of raw celebrity."

Oprah is beyond doubt a magnificent orator. But the idea of a reality show star running against a talk show host is troublingly dystopian. We don’t want to create a world where dedicated public service careers become undesirable and impractical in the face of raw celebrity. — Seth MacFarlane (@SethMacFarlane) January 9, 2018

Later, after a Twitter user questioned his argument, MacFarlane tweeted: "I don’t think anyone is questioning the breadth of her accomplishments. The observation is a more fundamental one: Will there still be room for the likes of Kamala Harris Kamala HarrisThe Hill's Campaign Report: Trump and Biden vie for Minnesota | Early voting begins in four states | Blue state GOP governors back Susan Collins Kamala Harris: Black Americans have been 'disproportionately harmed' by Trump Biden town hall draws 3.3 million viewers for CNN MORE or Maggie Hassan Margaret (Maggie) HassanCongress needs to prioritize government digital service delivery Senate Democrats demand answers on migrant child trafficking during pandemic Hillicon Valley: Feds warn hackers targeting critical infrastructure | Twitter exploring subscription service | Bill would give DHS cyber agency subpoena power MORE in the political future we’re creating, or only Tom Hanks?"

I don’t think anyone is questioning the breadth of her accomplishments. The observation is a more fundamental one: Will there still be room for the likes of Kamala Harris or Maggie Hassan in the political future we’re creating, or only Tom Hanks? https://t.co/na1fC0IkFZ — Seth MacFarlane (@SethMacFarlane) January 10, 2018

MacFarlane was referring to Sens. Kamala Harris (D-Calif.) and Maggie Hassan (D-N.H.).

Speculation has swirled this week about whether Winfrey will launch a presidential bid following her widely praised speech at the Golden Globes on Sunday.

Some Democrats have expressed interest in the idea of a presidential bid from the former talk-show host.

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Winfrey, a self-made African-American billionaire who grew up in poverty, has earned the respect of large swaths of the American public through her brand and charitable activity.

Winfrey has said in the past she is not interested in a presidential bid, but her close friend Gayle King said on Tuesday that Winfrey was "intrigued" by the idea.

CNN also reported on Monday that two of Winfrey's friends said she was "actively thinking" about a run.

Trump said on Tuesday he would beat Winfrey if they faced each other in a general election.

"Yeah, I'll beat Oprah. Oprah will be lots of fun,” he said, adding “I don’t think she’s going to run.”