EMBED >More News Videos On Monday, San Francisco Mayor Ed Lee spoke with ABC7 News and appeared to be in good health.

EMBED >More News Videos Former San Francisco Mayor Willie Brown is reacting to death of Mayor Ed Lee.

SAN FRANCISCO (KGO) -- San Francisco Mayor Ed Lee has passed away at the age of 65 at Zuckerberg San Francisco General Hospital.Lee suffered cardiac arrest while he was out shopping at about 10:30 p.m. Monday. He passed away at 1:11 a.m. at Zuckerberg San Francisco General Hospital.Just yesterday, Lee was at a recycling event in San Francisco where he was smiling and shaking hands.The mayor's office issued a statement this morning with the sad news: "It is with profound sadness and terrible grief that we confirm that Mayor Edwin M. Lee passed away on Tuesday, December 12 at 1:11 a.m. at Zuckerberg San Francisco General Hospital. Family, friends and colleagues were at his side. Our thoughts and prayers are with his wife Anita, his two daughters, Brianna and Tania, and his family."Several colleagues and officials near and far are remembering Mayor Lee.Rep. Nancy Pelosi said "He was a true champion for the people & a dear friend to the many lucky enough to know him."Senator Kamala Harris said: "He was a fierce advocate for civil rights and worked tirelessly for workers' rights and his leadership will be missed."Former San Francisco Mayor Willie Brown is reacting, calling Lee "bright, able and skilled at pulling politicians together."Lee was born May 5th, 1952 in Seattle, Washington. He was appointed mayor of San Francisco in January 2011 when former Mayor Gavin Newsom left to become California's lieutenant governor. He won election in November 2011 and re-election in November 2015. Lee was San Francisco's first Asian American mayor. Before becoming mayor, Lee was City Administrator.In accordance with the City Charter, Board of Supervisors President London Breed became Acting Mayor of San Francisco, effective immediately.Breed is a native San Franciscan. She's a graduate of Galileo High School.Prior to her election to the Board of Supervisors, she was the Executive Director of the African American Art and Culture Complex.She was elected to the Board of Supervisors in 2012, representing District 5 which includes the Fillmore/Western Addition, Hayes Valley, Lower Haight, Haight-Ashbury, Japantown, Alamo Square, North of Panhandle, Cole Valley, and Inner Sunset neighborhoods.Breed was then elected President of the Board in 2015.