Story highlights Protesters interrupted Donald Trump's North Carolina rally at least 10 separate times Friday night

The protests began about five minutes into the speech

Raleigh, North Carolina (CNN) Protesters interrupted Donald Trump's North Carolina rally at least 10 separate times Friday night in the most staged, disruptive protest of the mogul's presidential campaign to date.

The protests began about five minutes into the speech and continued until his closing lines nearly 45 minutes later, as different individuals and groups -- strategically placed in different locations all around the more than 7,000-person capacity auditorium -- caused disturbances with signs and chants.

Several of the protesters were connected to Black Lives Matter, either wearing clothing bearing the movement's name or chanting "black lives matter."

Other signs called out Trump's rhetoric, saying "Stop the hate, we make America great."

Each time, the crowd booed and the protesters were quickly removed by a combination of security and authorities, though Trump grew clearly more frustrated as the disruptions continued.

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