Matthew P. Sapolin, the Bloomberg administration’s disabilities commissioner, died of cancer on Tuesday. He was 41.

Mr. Sapolin, whose death was confirmed by the mayor’s office, had served as commissioner for the Mayor’s Office for People With Disabilities since the post was created in 2006. In that role, he pushed to make New York City’s building code more accommodating to people with disabilities, created a mentoring program and led an effort to freeze rents for some disabled New Yorkers.

Mr. Sapolin was also blind. Friends and colleagues said that while Mr. Sapolin’s blindness informed his life, it did not narrow it. He was an accomplished wrestler, a versatile musician, a formidable chess player and an occasional skier.

“His mother told him, you go to school and you’ll learn, and that’s it,” said Carol Robles-Román, deputy mayor for legal affairs. “You’re going to school with everybody else, and they’re going to treat you like everybody else.”