Introduction Corticosteroids are the mainstay of treatment for the acute phase of atopic dermatitis (AD), whereas topical emollients are mainly used for maintenance of remission. A topical agent that combines emollient and anti‐inflammatory properties would achieve control of all phases of AD, without the need for chronic corticosteroid use.

Aim To assess the efficacy of a novel topical agent containing superoxide dismutase (SOD) 100 000 IU and 4% of a combination of plant extracts (blackcurrant seed oil, sunflower oil concentrate, balloon vine extract).

Methods Twenty patients (age range from 8 months to 72 years old) with mild‐to‐moderate atopic dermatitis were assessed. The product was used as mono‐therapy, applied to the affected skin areas twice daily. Patients were evaluated before and after a 30‐day course using the SCORAD and the Visual Analog Scale for assessment of pruritus intensity. Primary endpoint was improvement of AD according to SCORAD and clinical assessment. Secondary endpoint was patient satisfaction and improvement of pruritus.

Results Mean SCORAD on day 0 was 32.61(range = 16.0‐46.9) and decreased to 10.55 (range = 0‐17.0) on day 30, reflecting a reduction of 67.6%. On day 30, all patients described significant improvement in pruritus and quality of sleep.