When it comes to success stories in the entertainment world, it doesn’t get much better than the one about a pair of regular guys from Colorado, Matt Stone and Trey Parker, who took cutout paper dolls, animated them and triumphed on cable television, on the Web, at the multiplex and on Broadway.

Last week, Mr. Stone arrived at a coffee shop in the Chelsea neighborhood of New York so bundled up that he resembled Kenny, who always shows up on “South Park” encased in a big orange parka. He was leaving the next day for London, where the fourth production of “The Book of Mormon” will soon begin a run.

Over the course of 16 seasons and 237 episodes, “South Park,” an assault on good taste built on the misadventures of four crudely animated and crudely spoken boys, has entered every pore of the culture. In the meantime, the two creators have helped put Comedy Central on the map, made four feature films, produced a sitcom and landed a Broadway hit with “Book of Mormon,” produced by Scott Rudin and Anne Garefino and created along with Robert Lopez.

Now Mr. Stone and Mr. Parker are about to finish a video game version of “South Park,” and they recently announced that they were forming a production company called Important Studios, valued at $300 million.