A woman has been charged with attempted murder after two people were stabbed over a clothing dispute during an alleged home invasion on the outskirts of Sydney, which police are investigating as a potential bikie-related feud.

Kristen Moriarty, 28, and a 32-year-old man linked to the Rebels bikie gang allegedly stormed a home in Mersey Road, Bringelly, wearing balaclavas and armed with a knife at 11.20pm yesterday.

Police were called to a nearby property, believed to be that of the male stab victim's parents, where they found two people injured after a knife attack.

A rifle remains on the ground after the incident. Picture: 9NEWS (9news)

Police have set up three separate crime scenes. Picture: 9NEWS (9news)

The man, 44-year-old Vince Dattilo, had been stabbed twice in his stomach and once in his back, while a woman, 29, had stab wounds to her neck and hand.

The third occupant of the home, a 44-year-old man, was uninjured.

Ms Moriarty has now been charged with aggravated break and enter, two counts of attempted murder and a number of serious assault charges.

Kristen Moriarty, 28, has been charged with two counts of attempted murder following the alleged home invasion. Picture: 9NEWS (9NEWS)

The 35-year-old driver was found suffering a gunshot wound at the crash on The Northern Road. Picture: 9NEWS (9NEWS)

But police say that Dattilo himself may now be facing charges, after he allegedly grabbed a high-powered rifle from inside his home and fired more than five times at the intruders as they drove away in a Holden Colorado, hitting the male driver in the right elbow.

The injured driver then sped off down The Northern Road, but only made it around two kilometres from the property before crashing into a telegraph pole at high speeds.

"Two offenders reversed out of the driveway when a 35-year-old man who was stabbed retrieved a 303 Winchester rifle and open fire upon the man and female," Liverpool Police Area Command Commander Acting Superintendent Paul Albury said.

"Two of the shots struck the driver’s side of the vehicle injuring the 32-year-old man. He drove for about three to five kilometres before he impacted heavily with a telegraph pole. (We allege) it indicates he was travelling at high speed."

(9news)

It is understood the man was so badly injured that a police officer was forced to drive the ambulance to Liverpool Hospital so paramedics could work on the victim.

He remains under police guard in hospital but is yet to be charged.

Ms Moriarty, 28 - who was uninjured in the crash - was hauled from the crumpled vehicle and arrested. She will spend tonight behind bars at Liverpool Police Station before facing Liverpool Local Court tomorrow.

The two stabbing victims remain in hospital with serious conditions, however, Dattilo's brother John told 9NEWS "he's doing better and he’s okay".

The two stabbing victims are in a serious condition. Picture: 9NEWS (9NEWS)

“We will allege the 32-year-old man has a link to an outlaw motorcycle gang," Act Supt Albury said.

“This is an alarming incident. Three people were in their home. There was no lead up to the incident. It must have been a very frightening and horrific scene.

“Firing a 303 Winchester rifle at a moving vehicle is an alarming escalation also. We expect that person will also be charged.

“We allege the 28-year-old woman was having a property-related dispute with occupants of the Bringelly address and went there to retrieve some property.

“I don’t believe it was any more complex than clothing and other personal belongings of the 28-year-old. I believe she had been staying at the property up until relatively recently.

“Some are interrelated. One of them I believe is an uncle of the owner of the premises."

Vince Dattilo, 44, was allegedly stabbed twice in the in the stomach and once in the back. Picture: 9NEWS (9news)

Police investigating the crime scene at Bringelly. Picture: 9NEWS (9news)

Act Supt Albury said the firearm used in the targeted attack was unregistered and that the 32-year-old was unlicensed.

"Some of the people are known to police," he said.

Neighbour Joe Vella told 9NEWS he and his wife were watching TV when they heard "this banging going on".

"There was probably five or six big, loud shots. It was about 15 seconds and it was all over," he said.

Neighbour Joe Vella told 9NEWS within 15 seconds the "bangs" were over. Picture: 9NEWS (9news)

"I was about to get out and have a look and my wife said you better stay in bed because we're used to this now.

"There's always the excitement in Bringelly now. It's pretty scary as it's so close to home.

"You're in your bed and you don't know if you're going to be one of the ones that's going to be stabbed or shot or whatever.

"But we keep to ourselves and we don't worry what's going to happen next door because it's on the other side of the fence."

The driver's exact condition is not known but he is expected to be released from hospital later today.