For Angelina Jolie, the scale and impact of the floods that have devastated Pakistan are apparent on the faces of those she meets.

She saw it in the eyes of a couple in their 70s - a husband who served twice in the military and built his house by himself for his family, one they've lived in for nearly 40 years.

"The man spoke to the fact that he never felt in his lifetime he is ever going to be able to recuperate what he lost," Jolie told Dr. Sanjay Gupta, CNN's chief medical correspondent. "That he would never have again nice things. He would never have a nice bed, a nice house. And she - they lived in this place since 1972. And raised their children and their grandchildren there. In a moment, a few hours, it was completely gone."

Jolie spoke to Gupta during her fourth trip to Pakistan as a spokeswoman for the U.N. refugee agency to help bring awareness to the country in the wake of devastating floods that have affected 21 million people.

It's a scene Jolie said may be hard for some to understand - especially because of how far away it is. If people saw the eyes of the children pleading for help, perhaps they'd understand the Pakistanis' will to live, she said.

"If they met all these children [who are] so resilient and are still children and so full of life and love and hope," Jolie said that she thinks people would grasp the situation better.

"I think it is - this part of the world, they are resilient people. Think of all that they have been hit with. They continue to move on, to rebuild."

Jolie said she wasn't sure what she'd see when she got to Pakistan. But after touring villages, the trip evoked a cause close to home for her - reminding her of the work Brad Pitt is doing in New Orleans, Louisiana, after Hurricane Katrina. It's a comparison she said she hopes will help people understand why they need to send aid.

"I thought I'm going to see a lot of wet areas and tents, and what I saw was if people could think about New Orleans and the scale of that and how devastating that was. ... There was so much that was full of toxic materials and death and that's on a huge scale, and this is no different."

Any conflict in the area shouldn't prevent people from caring, Jolie said.

"We have to support them," Jolie said. "For all the people worried about conflict in this part of the world, they think it is far away and don't understand the corruption. The only way to make for a healthier, more hopeful, stronger Pakistan and Afghanistan is to help support education and help people, especially in this time of need, and not allow for more devastation and more desperation."