Restaurateur Paul Mathis will complete a retail shake-up of Melbourne's Southern Cross railway hub when he opens a large restaurant at the station.

Mr Mathis' new 250-seat pizza-focused pub will sit under one of the station's yellow administration pods near Collins Street and is expected to be completed in mid-July.

The site for Paul Mathis' pizza restaurant at Southern Cross Station. Credit:Eddie Jim

Mr Mathis' CV boasts a string of the city's much-loved and talked about eateries, from Joe's Garage and Blue Train to Soulmama and Taxi.

He is well known for his popular Firechief pizzeria in Hawthorn East and South Wharf restaurants Bangpop (Thai) and Akachochin (Japanese) but his new venture will be a ''simple'' foodie-style pub, the Network Public Bar and Pizzeria on the main concourse.