Three Palestinians have reportedly been killed amid violent clashes across Jerusalem and the West Bank.

In Jerusalem, two Palestinians, a 17-year-old boy and 24-year-old man were killed by live fire, said Bayan Baidoun from the Mukassed Hospital.

A third Palestinian was killed in clashes in the West Bank, the Palestinian Health Ministry said, but did not provide further details.

Local media named the 17-year-old as Muhammad Mahmoud Sharaf, saying he was killed during protests in the Ras al-Amoud district of East Jerusalem.

Palestinians pray on the street close to Lion's Gate in the Old City of Jerusalem, closely watched by Israeli security during a mass street Friday prayer on 21 July 2017. (EPA)

The Palestinian Authority-linked Wafa news agency reported that he was shot in the neck by a settler and died of his wounds shortly afterwards, being buried later in the day.

Footage showed hundreds of Palestinians at the funeral, chanting "Allah akhbar" as they carried Muhammad's body through the streets.

Both his body and that of the 24-year-old were removed quickly from hospital for burial amid fears they would be seized by Israeli authorities, preventing the swift burials customary both Islam and Judaism.

At least one Israeli police officer was injured as Palestinians hurled rocks and missiles and started fires, and Israeli security forces responded with live fire, rubber bullets, tear gas and stun grenades.

The Palestinian Red Crescent said it had treated 193 injured people across Jerusalem on the West Bank so far on Friday, warning of “foreseen tensions and potential clashes”.

Thousands of Muslims had prayed in the streets surrounding the holy site known as Temple Mount by Jews and Haram al-Sharif by Muslims in the Old City.

They were protesting against the installation of metal detectors and other restrictions at the entrance to the al-Aqsa Mosque, after Palestinian gunmen killed two police officers there last week.

Trump's full remarks in Jerusalem

Muslim leaders had urged worshippers not to enter the sacred compound until Israel removes the detectors, portraying Israel's measures as an encroachment on Muslim rights.

The mufti of Jerusalem, Mohammed Hussein, told worshippers that he expects a “long test of wills” with Israel over the third-holiest site in Islam.

Israeli authorities have insisted the devices would stay, saying they are needed to prevent further attacks and arguing they go no further than measures at other sensitive sites abroad.

But a spokesperson suggested that officers may sometimes only choose to conduct spot checks, after Israel’s security cabinet decided not to overrule the decision to install detectors.

The military and the Shin Bet security service were reportedly opposed to the devices.

Friday prayers are frequently a flashpoint for protests and unrest in Jerusalem and the West Bank, with police severely restricting Muslim access to the area surrounding the al-Aqsa mosque and setting up checkpoints.

Around 3,000 police were deployed near the Old City, turning away Muslim men under the age of 50, while some worshippers intercepted before reaching Jerusalem as they journeyed toward the holy city.

The Israeli–Palestinian conflict intensifies Show all 10 1 /10 The Israeli–Palestinian conflict intensifies The Israeli–Palestinian conflict intensifies Medics evacuate a wounded man from the scene of an attack in Jerusalem. A Palestinian rammed a vehicle into a bus stop then got out and started stabbing people before he was shot dead AP The Israeli–Palestinian conflict intensifies Israeli ZAKA emergency response members carry the body of an Israeli at the scene of a shooting attack in Jerusalem. A pair of Palestinian men boarded a bus in Jerusalem and began shooting and stabbing passengers, while another assailant rammed a car into a bus station before stabbing bystanders, in near-simultaneous attacks that escalated a month long wave of violence AP The Israeli–Palestinian conflict intensifies Youths attend the funeral of Ahmad Sharake who was shot during clashes with Israeli forces in Jelazun refugee camp, near Ramallah, West Bank. Tensions in the area continue to run high following a series of stabbing attacks that have occurred around Israel in clashes between Palestinian youths and Israeli security forces Getty Images The Israeli–Palestinian conflict intensifies Palestinians throw molotov cocktail during clashes with Israeli troops near Ramallah, West Bank. Recent days have seen a series of stabbing attacks in Israel and the West Bank that have wounded several Israelis AP The Israeli–Palestinian conflict intensifies Women cry during the funeral of Palestinian teenager Ahmad Sharaka, 13, who was shot dead by Israeli forces during clashes at a checkpoint near Ramallah, at the family house in the Palestinian West Bank refugee camp of Jalazoun, Ramallah AP The Israeli–Palestinian conflict intensifies A wounded Palestinian boy and his father hold hands at a hospital after their house was brought down by an Israeli air strike in Gaza Reuters The Israeli–Palestinian conflict intensifies Palestinians look on after a protester is shot by Israelis soldiers during clashes at the Howara checkpoint near the West Bank city of Nablus EPA The Israeli–Palestinian conflict intensifies A lawyer wearing his official robes kicks a tear gas canister back toward Israeli soldiers during a demonstration by scores of Palestinian lawyers called for by the Palestinian Bar Association in solidarity with protesters at the Al-Aqsa mosque compound in Jerusalem's Old City, near Ramallah, West Bank AP The Israeli–Palestinian conflict intensifies Undercover Israeli soldiers detain a Palestinian in Ramallah Reuters The Israeli–Palestinian conflict intensifies Palestinian youth burn tyres during clashes with Israeli soldiers close to the Jewish settlement of Bet El, in the West Bank city of Ramallah, after Israel barred Palestinians from Jerusalem's Old City as tensions mounted following attacks that killed two Israelis and wounded a child

Anger over perceived moves by Israeli authorities to restrict Muslim access to the al-Aqsa mosque and lessen control by its Jordanian custodians has been a major source of increased tensions over the past two years, which have seen in a spike in Palestinian attacks and shootings by security forces.

Jordan has repeatedly appealed to Israel to remove the metal detectors and thousands of Jordanians protested in Amman on Friday.

The compound houses the Dome of the Rock and al-Aqsa mosque, and is the third holiest site in Islam.

But it was once home to biblical Temples and so is Judaism's holiest site. The Western Wall, a Temple remnant, is the holiest site where Jews can pray.

Palestinian President Mahmoud Abbas has asked the US to “intervene urgently” and compel Israel to remove metal detectors, according to his adviser, Nabil Abu Rdeneh.

He said Mr Abbas discussed the growing tensions in Jerusalem in a phone call with Donald Trump’s Middle East adviser and son-in-law, Jared Kushner.

The Palestinian leader told Mr Kushner that the situation is “extremely dangerous and may go out of control,” Mr Abu Rdeneh added.