Best known for playing the proud bisexual character Callie Torres on “Grey’s Anatomy,” actress Sara Ramirez came out publicly for the first time today in a powerful speech at the True Colors 40 to None summit.

“So many of our youth experiencing homelessness are youth whose lives touch on many intersections—whether they be gender identity, gender expression, race, class, sexual orientation, religion, citizenship status,” Ramirez said.

“And, because of the intersections that exist in my own life: Woman, multi-racial woman, woman of color, queer, bisexual, Mexican-Irish American, immigrant, and raised by families heavily rooted in Catholicism on both my Mexican and Irish sides,” she continued, “I am deeply invested in projects that allow our youth’s voices to be heard, and that support our youth in owning their own complex narratives so that we can show up for them in the ways they need us to.”

Ramirez, who has been married to husband Ryan DeBolt since 2011, is a member of the True Colors Fund board of directors and an outspoken advocate for LGBTQ rights.

Watch her full remarks below.