A man has fronted court charged with murdering a man and seriously inuring the man's brother after allegedly running them down with a car in Braybrook.

Ahmed Awalow Sharif, 26, fronted Melbourne Magistrates Court on Wednesday following the alleged attack on brothers Paul and Sean Duncanson on Saturday night.

Paul Duncanson. Credit:Facebook

Police have previously said the pair were struck by a car and then assaulted with weapons by a group of men outside a house in Castley Crescent about 9.30pm.

Mr Sharif, 26, is charged with murdering Paul Duncanson, 40, and intentionally causing serious injury to Sean Duncanson, 44, who was this week in an induced coma in hospital.