ADELAIDE midfielder Curtly Hampton is set to miss multiple games with the right ankle injury he sustained in Saturday's 80-point win over the Brisbane Lions.

The former Giant had played each of the Crows' nine matches this year – after a foot injury ruined his debut campaign at West Lakes – but the club's general manager of high performance, Matt Hass, has already ruled him out for this weekend.

"Unfortunately for (Hampton), it's a high ankle sprain," Hass told afc.com.au.

"We'll collect a bit more information this week, but it's safe to say he'll miss a period of time."

Defender Brodie Smith (hamstring tightness) also finished the Lions clash on the bench and faces a fitness test before taking his place against Fremantle on Saturday night.

Half-forward Riley Knight (corked glute) is on track to return after a fortnight out, while Troy Menzel (corked quad) will also have to pass a fitness test after missing the Lions game.

Hass also reported that ex-Collingwood wingman Paul Seedsman, who is yet to play at any level this year, was nearing a comeback from a long-term groin injury.

Seedsman hopes to return somewhere around the time of Adelaide's round 13 bye, which falls in mid-June.

"(Seedsman) continues to make some significant strides in his rehab from his groin injury," Hass said.

"He’s started to train in a modified setting with the main group and we expect him to be back in the next few weeks."

Mitch McGovern (hamstring) is also aiming for a mid-season return.

Defender Kyle Cheney and rookie key-position prospect Alex Keath made successful returns from hamstring injuries in the Crows' SANFL win over West Adelaide at the weekend.