Five doctors are among seven Gold Coast University Hospital staff stood down over allegations of serious fraud that have been referred to Queensland's Crime and Corruption Commission (CCC).

Gold Coast Hospital and Health Service (GCHHS) chairman Ian Langdon said the clinical and administrative staff were being stood down following concerns raised regarding patient referral processes.

"These are serious claims that may have begun well over a year ago," Mr Langdon said.

"They will be thoroughly investigated."

Premier Annastacia Palaszczuk said she found the allegations "very concerning".

"I was shocked as I believe many other people were to hear about those allegations," she said.

"We will let them be investigated. But it's extremely disappointing that people in this day and age would still be involved in those sort of practices."

"I am absolutely appalled that these allegations have been made."

Health Minister Cameron Dick said he had spoken to Mr Langdon.

"I'm very concerned by the nature of the allegations and they must be fully and properly investigated," Mr Dick said.

GCHHS chief executive Ron Calvert said five doctors were part of the investigation and they had been stood down on full pay.

The ABC has been told the doctors work in the Gold Coast University Hospital cardiology unit.

"I need to stress that what's happened has nothing to do with clinical care, the quality or safety of the service that we offer here," Mr Calvert said.

"I'm very, very pleased with the response we've had from the cardiology community as a whole, the network."

The hospital had accepted offers of support from private sector doctors on the Gold Coast.

"I am pleased with that response and that means we are still providing a high quality emergency service for anything that may crop up," Mr Calvert said.

"I can't say that elective services, like outpatients, will not be affected by this.

"We'll do our very best to ensure that there is the minimum possible disruption to patients and if the response we've had in this last 24 hours is anything to go by it wouldn't surprise me if there's no disruption to patients."

Mr Calvert said as part of normal protocol he was not privy to the specifics of the fraud allegations.

Asked about reports it involved hundreds of thousands of dollars, he said: "It wouldn't surprise me".

"By the nature of these things that's what it can climb to, but I've no detail I'm afraid."

Metro South allegations under internal investigation

Meanwhile, Queensland Health confirmed it was investigating allegations of favouritism in the 2013 recruitment of a staff member within the Metro South Hospital and Health Board.

A department spokesman said a senior executive was suspended earlier this month after an anonymous allegation.

The case was referred to the CCC, which sent it back to Queensland Health for an internal investigation.