Seventh Day Adventists were human guinea pigs in Operation Whitecoat

The remarkable story is told in a BBC Radio 4 documentary, Hotel Anthrax.

In the 1950s, the Seventh-day Adventist Church struck an extraordinary deal with the US Army. It would provide test subjects for experiments on biological weapons at the Fort Detrick research centre near Washington DC.

The volunteers were conscientious objectors who agreed to be infected with debilitating pathogens. In return, they were exempted from frontline warfare.

Fort Detrick was working on weapons it could use in an offensive capacity as well as ways of defending its troops and citizens.

Hotel Anthrax uses declassified documents, evidence from Senate investigations and personal testimony to trace the American bio-weapon programme during this period.

The research involved anthrax, other lethal bacteria and biological poisons. The scientists also conducted tests on an unsuspecting American public.

Rabbit fever

More than 2,000 volunteers, nicknamed the "white coats", passed through Fort Detrick between 1954 and 1973, where they worked as lab technicians, as well as offering up their bodies for science.

One white coat, George Shores, tells of how he was infected with tularaemia or rabbit fever.

Even my gums hurt. I don't think I have ever been so sick in all my life

George Shores

"They had like telephone booths all the way around the outside of the Eight Ball and you went into the telephone booth and shut the door and put on a mask like a gas mask.

"It was hooked up to the material that was inside the Eight Ball and you breathed it in," explained Mr Shores.

He began to feel ill before too long.

"Even my gums hurt. I don't think I have ever been so sick in all my life. First it started as a headache and achy feelings and it just kept progressing.

"I just wanted to breathe enough to keep alive. I would just take little gasps of breath and I would hold it for as long as I could because it hurt so bad.

"I can imagine if someone was using that agent in the battlefield the soldier would just have to lie down - he would not be able to function."

Fort Detrick is a US Army biological warfare research facility

But America's Institute of Medicine is conducting a study of more than 6,000 veterans who say their health has been compromised by secret tests in the Cold War years.

Some of these were veteran sailors who were involved in tests known as SHAD - Shipborne Hazard and Defense - which involved spraying lethal chemicals such as sarin and nerve gases in the open sea.

The BBC programme makers also obtained declassified documents prepared by the US Department of Veterans Affairs which refer to a study of nearly 100 SHAD veterans who have since died.

It found the veterans were three times more likely to have developed one of a group of killer diseases as a sample group in the general population.

It concludes: "This study does suggest that veterans who participated in Project SHAD may be at increased risk for cerebrovascular and respiratory diseases."

Subway experiment

But it wasn't just the white coat volunteers and sailors who were subject to experiments. Scientists used what they thought was a harmless simulant in major bio-weapon tests across US cities and on public transport.

It was a bacteria which they believed was harmless but which would mimic the dispersal of deadly biological agents such as anthrax.

But later research showed that the strain of Bacillus globigii, or BG, did pose a risk to people who were ill or whose immune system was failing.

The programme hears from a retired scientist whose job in 1966 was to drop light bulbs carrying BG on the New York subway. He would then measure how the simulant might spread in the event of a real attack, using a motorised vacuum devise concealed inside a suitcase.

Wally Pannier, 82, recalls: "We'd just drop light bulbs with the powdered stimulant inside.

"I think it spread pretty good because you had a natural aerosol developed every few minutes from every train that went past."

It's very hard to try and put today's ethics on standards 20, 30, 40 years ago

Dr Michael Kilpatrick

It was chaired by John D Rockefeller.

In a damning report, it concluded that the Department of Defense (DoD) repeatedly failed to comply with required ethical standards when using human subjects in military research - and that the DoD demonstrated a pattern of misrepresenting the danger of various exposures and continued to do so.

Dr Michael Kilpatrick, a medical adviser to the DoD, claims the concerns which SHAD veterans have been raising may, finally, be changing that behaviour.

"It's very hard to try and put today's ethics on standards 20, 30, 40 years ago. That's not to excuse it. I think they were trying to protect people using the medical science that was available at that time.

"We're taking a look at any current tests that require consent of our military personnel.

"We're making sure that there is an archive, a registry, a way to get back to all of the information."

Hear part 1 of Hotel Anthrax at Radio 4's Listen again page.

Part 2 is on Monday, 20 February, 2006 at 2000 GMT.