Thanks to Obamacare, the health-care industry is going to get a big makeover during the coming years and venture capitalists have wasted no time looking for ways to cash in. (Read more: How bad are Obamacare tech hurdles? Real bad, poll finds) "This is the greatest opportunity I've seen in my lifetime. It's the first time we are seeing really fundamental changes happen. And there's a lot of money that can be made as this chaos is sorted out," said Lisa Suennen, the co-founder and managing member of Psilos Group, a health-care-focused venture capital firm. With trillions of dollars estimated to be spent on Obamacare as it gets going and trillions more to be reallocated, it's no wonder VCs see this as a huge opportunity. The Affordable Care Act, which expands coverage to an estimated 32 million uninsured Americans, makes coverage mandatory.

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With that many people coming online, health-care providers will essentially be forced to find new ways to manage patients and costs, experts say. Consumers will be affected in a similar manner. "Obamacare will do a couple of different things. The No. 1 thing it has already done is it has brought the health-care system to the national stage. People are thinking about how health care is brought to them," said Ted Maidenberg, a general partner at The Social+Capital Partnership. "People will be thinking about better ways to consume and manage health, their pocketbook will be more affected and in general that will have consumers wanting more options. And health-care providers, they aren't going to build more hospitals and hire more doctors. They are going to to have to find new ways to inject millions of people into the system through technology."

Exchanges

So venture capitalists are placing their bets on a slew of different companies that they believe will profit from the overhaul of the system and one of the biggest areas some see potential in is the exchanges. (Read more: Here's how health insurance exchanges work) EHealth, a publicly traded company that owns Ehealthinsurance.com, is one of these companies benefiting from the federal mandate. Its stock is up 50 percent since July. Investors are also betting on companies that provide the backbone of support for both new government run health insurance exchanges as well as the growing sector of private health exchanges. (Read more: Young people may not 'get' Obamacare) The government Obamacare exchanges were established to offer insurance to the uninsured so they can comply with the new mandate to have insurance. The private health exchanges are being used by companies to offer a variety of insurance options to both current and retired employees. GetInsured and Liazon are just a couple of the venture-backed companies looking to power these types of exchanges. Extend Health, which Psilos had invested in, was also a player in the space but was recently acquired by Towers Watson. (Read more: Vast majority of Obamacare exchange visitors don't enroll)

"Just like when the Internet first came about, it was the guys who built routers and servers that made all the money it will be the guys building the backbones and enterprise software systems for these exchanges that will make a lot of money," said Suennen.

Data companies

Not surprisingly investors also see a promising future for software companies focused on data-driven solutions in the health-care space. But not all are as obvious as you might think. (Read more: Veeva Systems IPO shows updraft in cloud business) For example, Maidenberg is invested in a company called Propeller Health, which is a company that uses a sensor on an asthma patient's inhaler to collect data about the patient's condition. The collected data can be shared with the physician to remotely monitor the patient's condition and know when a change in treatment is necessary. The doctor can easily monitor a roster of asthma patients with the company's software, which is basically a dashboard that looks a lot like the Salesforce interface. The software helps the doctor to determine who is more likely to be hospitalized based on their behavior and helps the doctor to know when to be proactive about adjusting care. Data companies also will be key in helping companies decide whether or not they should adopt a private exchange or keep their health plans, said Michael Yang, managing director of Comcast Ventures. Basically, employers will need to figure out which health-care option is more affordable for them to provide and that creates demand for companies that can analyze data about their current and past employees, Yang said.

Consumerization of health