Security cameras have captured the dramatic moment a man was run down by a woman after a domestic dispute in the Adelaide Hills.

The vision shows the vehicle hit the man, aged in his 40s, in a carpark on the Old Princes Highway at Littlehampton around seven o'clock last night

He became trapped under the car, with the driver getting out of her vehicle before witnesses come to the man's aid.

The car drives straight at the man and takes him out. Picture: 9News (9news)

"She said, I ran him over and I started freaking out, so I got the jacks out my car to help try to get it up," said Natalia Palma who was first on the scene.

"He was yelling get this car off me I can't breathe."

"I said I will call the Police and she said no, and I got a bit scared."

Police speak to the driver of the vehicle. Picture: 9News (9news)

Emergency crews rushed to the scene and helped carefully left the car and free the victim from underneath.

He was rushed to the Royal Adelaide Hospital with serious injuries, however they are not considered life-threatening.

A 49-year-old woman from the Adelaide Hills was arrested at the scene and has since been charged with aggravated assault cause harm and driving unlicensed.

Paramedics treat the man who was trapped under the car. Picture: 9News (9news)

Police say the pair is known to each other and a Police Interim Intervention Order has been served to provide further protection for the victim.

"She was just yelling at him .. it was just a really scary moment," Ms Palma said.

"I was shaking, I didn't know what to do, what to say, I didn't really want to get involved too much."

Witnesses came to the aid of the man in his 40s who was taken to hospital with serious injuries. Picture: 9News (9news)

"He is very lucky, very lucky. I'm just glad he's ok now."