At the present time, psychedelics are among the most strictly controlled and criminalized substances over much of the world [ 154 ]. The context of usage is an essential factor with regard to the beneficial effects of these powerful substances, and neglecting contextual parameters can impose risks to users and lead to a lack of clinical effectiveness [ 153 ]. Given the strict regulations in places governing clinical investigations with psychedelics, research is often conducted in medically monitored hospital environments, although care has been taken to incorporate nature imagery into psilocybin therapy rooms. A recent study examining the effects of mindfulness meditation on the psilocybin experience was conducted in the less clinical setting of an alpine meditation retreat centre, where the practice of mindfulness meditation was found to enhance psilocybin’s positive effects while appearing to counteract potential dysphoric or anxiety reactions, with the pristine retreat setting likely contributing to this finding [ 155 ]. The current result of natural settings affecting psychedelic-induced nature-relatedness changes, together with the known benefits of increased nature relatedness and exposure to the individual and potentially, society, suggests that providing monitored psychedelic sessions in more natural settings may hold a unique potential and supports the principle of incorporating nature into the psychedelic-therapeutic centres of the future. By fostering nature relatedness, such experiences may be particularly beneficial not only for individual psychological well-being but also at a societal level and for the biosphere beyond - by increasing environmental concern and associated pro-environmental behaviours. A recent online study examining lifetime experiences with classical psychedelics found their usage (but not that of other consumed substances) to strongly predict self-reported pro-environmental behaviours. This relationship was found to be mediated by people’s degree of nature relatedness, particularly their self-identification with nature [ 43 ]. Environmental values and behaviours—plus nature relatedness—have been identified as being strongly linked in a number of studies [ 2 156 ], with the latter being the best predictor of ecologically conscious behaviour [ 65 ]. Pro-environmental behaviour has been found to be strongly linked to prosocial behaviour, with an increase in one fostering an increase in the other through their mutually enhancing interrelationship [ 157 ]. However, it is possible to conceive how self-identification with nature may on the other hand potentially also increase depression, anxiety or stress as a result of increased environmental concern and awareness of local and global ecological degradation [ 58 ]. The initially dystonic diminishing of ego-defenses as a result of enhanced sensitivity to the nonhuman world may be seen as an intermediate step to attaining a more meaningful sense of self as part of a wider ecological framework [ 158 ]. Considering the intense vulnerability that such states may entail, the importance of a safe setting and psychological support during psychedelic experiences cannot be stressed enough, especially in the presently discussed context of recreational and self-medicative use outside of controlled clinical and laboratory environments [ 123 ].