He's achieved international stardom with his expletive-laden attacks on US President Donald Trump and condemnation of gun laws in his popular Netflix specials.

But despite having differing views, Australian-born comedian Jim Jefferies was never going to shy away from an interview with politician Pauline Hanson.

The 40-year-old funnyman came face-to-face with the firey senator, with the equally outspoken pair debating Islam in Australia - a discussion that led Jefferies to admit: 'Maybe she's not as Trump-y as I remembered?'

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Despite sharing different views, Australian-born comedian Jim Jefferies (left) was never going to shy away from an interview with controversial One Nation founder Pauline Hanson (right)

Jefferies, who was born in Perth but is now a star in the US, met with Senator Hanson as part of an interview set to air on the Comedy Channel this week.

Known for regularly raising controversial topics in his stand-up routines, Jefferies did not waste a moment getting into a debate with the One Nation founder.

Touching on a key focus of Ms Hanson's since she became a household name in the 1990s, the comedian kicked off their chat by asking what 'Australian values' are.

'Pride in who we are as a nation... but Australia is also embraced by other cultures that have come here as well,' Senator Hanson replied.

'What I really want for everyone is that we can live in harmony, live in peace.'

Seemingly impressed with her response, Jefferies admitted he may have been wrong to associate Senator Hanson with the U.S. President.

Touching on a key focus of Ms Hanson's since she became a household name on her entrance to parliament in 1996, Jefferies kicked off their chat by asking what her 'Australian values' are

Jefferies then moved onto the controversial topic of Islam and Muslims in Australia, one which Ms Hanson has been outspoken about since her return to Canberra

'Maybe she's not as Trump-y as I remembered?' the comedian said.

But in an effort to test out his claim, Jefferies moved onto the controversial topic of Islam and Muslims in Australia.

'You've been quoted as saying that Islam was a disease?' Jefferies asked the senator.

Senator Hanson responded: '[We] should be vaccinated against it, by all means! Yes I did.'

The politician, who has been outspoken in her views against Islam, told Jefferies it simply was 'not compatible' with Australia.