Most patients will experience some post-procedural pain at the injection site for up to 3 days and in some cases longer. This is typically managed with ice and over-the-counter pain relievers like Acetaminophen (Tylenol); however the physician may prescribe stronger pain relievers. Non-steroidal anti-inflammatory agents (NSAIDS) should be avoided since they interfere with the effectiveness of the PRP treatment.

Other side effects of PRP injections are very limited as the patient is utilizing their own blood, which they should have no reaction to. Sometimes the color around the skin of a PRP injection will appear bruised. Most of these side effects are temporary and resolve spontaneously within a couple of days after the initial procedure. Rare complications includes infection at the injection site and bleeding especially with anticoagulant therapy or bleeding disorders.