" " Yep, the one on the right is a fruit; the one on the left is an animal. But we do have some common DNA. HowStuffWorks

During party conversation, at a trivia night or even in a "Dude Perfect" video, you may have heard the fun little factoid that humans and bananas share 50 (or 60) percent of the same DNA. Huh? There seems to be a ton of difference between a person and a piece of yellow fruit, starting with the fact that one is an animal and the other is a plant! Actually, there is some truth to that startling statistic, but it's not the whole truth.

This piece of info likely originated from a program run by the National Human Genome Research Institute back in 2013, although other similar data may have been run elsewhere. This particular effort was led by genetics expert Dr. Lawrence Brody, but in an unusual twist, Brody says the experiment was not published, as most scientific research is. Instead, it was generated to be included as part of an educational Smithsonian Museum of Natural History video called "The Animated Genome." That video noted that DNA between a human and a banana is "41 percent similar."

So, in order to find out how this similarity was determined, we talked with Dr. Brody himself. "It's funny how it's gotten legs," Brody says of the banana/human comparison.



Human vs. Banana

First, it's important to understand the difference between DNA and protein products. Brody says that an easy way to do this is to think of DNA as the blueprint of a house, and protein products as the actual house because all of the information is in there. Then, think of human DNA as a blueprint of a ranch home and banana DNA as that of a colonial-style home. In each house, a bunch of things are similar (plumbing, bathrooms, kitchen) but the end products are both quite different. That's how it works with humans versus just about everything else, from bananas to chimpanzees.

The second thing to keep in mind is that genes, which are the regions of the DNA that code for these proteins, only make up 2 percent of your DNA.

For this particular experiment, scientists first looked at the sequences of genes in a typical banana genome. "We then used these DNA sequences to predict the amino acid sequence of all the proteins that would be made from those genes," Brody says, noting that the protein sequences were placed in a file. "We then did the same process for all human genes."

Next, the scientists compared the protein sequence from each banana gene to every human gene. "The program compares how similar the sequence of the banana genes are to each human gene," he says, noting that the degree of similarity could range 0 to 100 percent. "The program kept any matches that were more similar than one would expect by chance." The program continued doing this, gene by gene.

All told, more than 4 million comparisons were done, resulting in about 7,000 best "hits" between the two genomes. Then, the percent similarity score for each of those hits was averaged. "This gave us the result of about 40 percent," he says. "This is the average similarity between proteins (gene products), not genes." Gene products or proteins are the biochemical material resulting from a gene becoming functional. "Of course, there are many, many genes in our genome that do not have a recognizable counterpart in the banana genome and vice versa."

If that's a bit difficult to chew and swallow, here's a more simplified breakdown. Essentially, they took all of the banana genes and compared them one at a time to human genes. From that, they culled a degree of similarity (if the banana had the gene but the human didn't, that didn't get counted). About 60 percent of our genes have a recognizable counterpart in the banana genome! "Of those 60 percent, the proteins encoded by them are roughly 40 percent identical when we compare the amino acid sequence of the human protein to its equivalent in the banana," Brody adds.

It may seem shocking that so many genes are similar in two such vastly different things as person and banana. But actually, it's not. "If you think about what we do for living and what a banana does there's a lot of things we do the same way, like consuming oxygen. A lot of those genes are just fundamental to life," Brody says.



We're All Relatives

So, when people repeat the percentage as being "a similarity of DNA," actually what the research looked at was the similarity of gene products. "It's a pretty minor mistake," Dr. Brody reassures. "The kernel that you would take home is that we have something in common with a banana and a potato and a pine tree. That part is true. The fine point about the gene products or the DNA, it's easy to see how that would get translated [incorrectly]."

So, if a scientist looked at the DNA sequence of a banana and compared it with the DNA of a human it wouldn't align. "You share 50 percent of your DNA with each of your parents. But with bananas, we share about 50 percent of our genes, which turns out to be only about 1 percent of our DNA," emails Mike Francis, a Ph.D. student in bioinformatics at the University of Georgia.

As we said earlier, genes make up just 2 percent of your DNA. So, what's the other 98 percent made up of? Eight percent of the rest of your DNA regulates genes (as to whether a gene should be turned on or off). The other 90 percent appear to have unknown functions or functions that have been lost through evolution. "These unknown sections of DNA used to commonly be called 'junk DNA,' because it was thought to do nothing. I hesitate to use the phrase 'junk DNA,' because each year it seems we realize more of this 'junk' is actually functional," says Francis.

Humans don't just share a high percentage of DNA with bananas – we also share 85 percent DNA with a mouse and 61 percent with a fruit fly. "The remarkable thing is that despite being very far apart in evolutionary time, we can still find a common signature in the genome of a common ancestor," Brody says. "These are preserved because the genome of an organism that lived billions of years ago contained genes that helped cells live and reproduce. Those same genes are preserved in us and plants."

Francis adds that humans likely share about 1 percent of their DNA with other fruits as well. "This is because all life that exists on earth has evolved from a single cell that originated about 1.6 billion years ago," he says. "In a sense, we are all relatives!"