For the second time in as many UFC fights, Alistair Overeem finds himself on the wrong side of a drug testing controversy.

The wound is still fresh, but here's what we know so far: Overeem failed a surprise drug test issued on Tuesday, March 27, following the UFC 146 press conference. Overeem's testosterone/epitestosterone levels ranked above a 10-to-1 ratio, far exceeding the 6-to-1 limit. The heavyweight now has a right to request testing of his "B" sample, and will be required to appear in front of the Nevada State Athletic Commission (NSAC) if he hopes to seek licensure.

In the interim, it appears as if Overeem's heavyweight championship fight against Junior dos Santos at UFC 146 is in severe jeopardy, throwing the UFC's entire heavyweight extravaganza into disarray.

Following the NSAC's announcement, a surge of Overeem's contemporaries took to Twitter, along with dos Santos' management team and BALCO founder Victor Conte, to weigh-in on the mess.

The UFC has made no announcement regarding @junior_cigano 's fight. We have no comment, this matter falls solely to NV Commission & UFC. — Ana Claudia Guedes (@GuedesGroup) April 4, 2012

I'm shocked.. Has the body fat of a tooth brush, looks like the guy on STREETFIGHTER. My mind is blown, just blown. — chael sonnen (@sonnench) April 5, 2012

Surprise, surprise...RT @Rweetherley: @SMOOTHone155 What do you think about Overeem testing positive? — Benson Henderson (@SMOOTHone155) April 5, 2012

1, 2, 3, everyone act surprised that Overeem tested positive. 😳 hate that I won't see the fight but this is why random testing is good. — Kenny Florian (@kennyflorian) April 4, 2012

@kennyflorian agreed! Well said sir — Tony Cucuy Ferguson (@TonyFergusonXT) April 4, 2012

"@Anvil_90 who would you like to see fight dos santos if overeem fails 2nd sample? - @theFrankMir :-) — Dan Hardy (@danhardymma) April 4, 2012

Wow!!!!!!!!Thanks @Alistairovereem for ruining the best fight of the night for @ufc for testing positive for Steroids! :-( #Disappointed — Keith Berry (@kokid951) April 4, 2012

The 6:1 T/E rule in NEVADA needs to be CHANGED! Period. California & most of the world have been using a 4:1 limit over 5 yrs. GET REAL! — Victor Conte (@VictorConte) April 4, 2012

When is @danawhite going to wake up and smell the UFC testosterone abuse party! How much more obvious can this rampant problem become? — Victor Conte (@VictorConte) April 4, 2012

Will Rampage Jackson be one day be known as the Jose Canseco of MMA? — Victor Conte (@VictorConte) April 4, 2012

RT @wigerilla: Now lets not over react about Overeem's high test for testosterone. He'll reveal which part of the horse he eats case closed. — Conor Heun (@ConorHeun) April 5, 2012

"@BrianStann: @TomKongWatson sorry about your hero buddy!" hahaha that's what happens in America. They take the European down. Conspiracy! — Tom Kong Watson (@TomKongWatson) April 4, 2012

wow...overeem fails a drug test. Does this open the way for an early title shot for @thefrankmir? — John Hathaway (@ufcjohnhathaway) April 4, 2012

"It wasn't me, it was the horses, I swear!" - Alistair Overeem — Joe Duarte (@JoeDuarteMMA) April 5, 2012

No one can be surprised about overeem butIt really does suck the match up had potential #instantclassic — Steven Siler (@Stevesiler) April 5, 2012

"@mauroranallo: Oh and if Overeem is indeed out of the title fight at UFC 146,then my pick to replace him is Frank Mir." CAIN! — Cung Le (@CungLe185) April 5, 2012

Taking a drug test for some fighters is like a girl taking a pregnancy test after a close call . #nervous SMDH — Derek Brunson (@DerekBrunsonMMA) April 4, 2012

Yeah I'm angry . Alistair Overeem you big idiot . What makes your think you can keep pumping away . People are so ungrateful and stupid ! — Derek Brunson (@DerekBrunsonMMA) April 4, 2012

Nooooooooooo! "@arielhelwani: NSAC announces that Overeem tested pos. for elevated levels of test. last wk." — MarloesCoenen (@MarloesCoenen) April 4, 2012

If one fighter test positive for juice then the other one test positive the same. It's a fair right? Lmao — DaMarques Johnson (@DaMarques_UFC) April 4, 2012