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One of the major goals of Biology is to understand the mechanisms that

underlie genotype-phenotype relationships.

How do Mendelian mutations lead to Mendelian disorders?

How do functional variants located in loci found in Genome-Wide

Association Studies, or GWAS, lead to complex traits?

And how do cancer-associated mutations lead to tumorigenesis?

These are questions for which we still

lack mechanistic answers in many cases.