BEREA, Ohio -- The Cleveland Browns will be without cornerback Joe Haden and safety Tashaun Gipson when they face Peyton Manning and the Denver Broncos on Sunday.

Haden has a concussion, and Gipson is nursing a sprained ankle. Neither practiced all week.

If the Broncos want to get a struggling offense going, it doesn't hurt to have two Pro Bowlers missing from the opposing secondary. Denver ranks 30th in total offense (302.6 YPG) and 23rd in passing (231).

Jordan Poyer will replace Gipson. He played in the win over the Baltimore Ravens and was given one of the defensive game balls.

Pierre Desir steps in at corner. Desir started against the San Diego Chargers two weeks ago and played fairly well but did give up a touchdown to Keenan Allen on a deep fade.

"It's never ideal when you're down guys," Browns coach Mike Pettine said. "But we're confident in the depth and how those guys prepare."

Running back Isaiah Crowell is listed as questionable with a toe injury. He was limited in Friday's practice.

Robert Turbin will be available for the first time since being acquired on waivers from the Seattle Seahawks the week before the opener. The Browns picked up Turbin even though he had a high ankle sprain.