A church has gone up in flames on Good Friday, the fourth church fire this week.

Firefighters were called just after 2.30pm to the St David's Anglican Church on Doncaster Road after at least one witness reported smoke coming from the building in Doncaster East.

The fire was contained to a small part of the building and extinguished. The cause has not been determined but has been deemed suspicious, a Metropolitan Fire Brigade spokesman said on Saturday.

It is the fourth suspicious church fire that has occurred in Melbourne since Monday. St James Church in Brighton, St Mary's in St Kilda East and St Mary's Catholic Church in Dandenong have all suffered suspected arson attacks in the past six days.

The three other churches are all Catholic churches connected to notorious paedophiles, including priests Kevin O'Donnell and Ronald Dennis Pickering.

Police said all of the fires were being treated as suspicious, but would not comment on whether the blazes could be linked.

Investigators want to speak to any witnesses or anyone with any information, urging them to call Crime Stoppers on 1800 333 000 or visit www.crimestoppersvic.com.au.