Negative mood, such as sadness and anger, is associated with higher levels of inflamation and may be a signal of poor health, according to a study. Researchers from the Pennsylvania State University in the US found that negative mood measured multiple times a day over time is associated with higher levels of inflammatory biomarkers. This extends prior research showing that clinical depression and hostility are associated with higher inflammation. Chronic inflammation can contribute to numerous diseases and conditions, including cardiovascular disease, diabetes and some cancers. The study, published in the journal brain, behavior and immunity, is the first examination of associations between both momentary and recalled measures of mood or affect with measures of inflammation.