Retail marijuana shops in Northampton and Leicester received clearance to make Massachusetts history and start selling their products in three calendar days.

The first sales are looking likely to occur on Tuesday, Nov. 20.

The Massachusetts Cannabis Control Commission announced Friday that they've provided the final sign-offs to Cultivate Holdings, LLC, which has a retail shop in Leicester, and New England Treatment Access (NETA) LLC, which is readying a store in Northampton, to start selling marijuana and marijuana products.

Cultivate, which owns a medical marijuana dispensary at the same location in Leicester, plans to start selling recreational marijuana on Tuesday.

NETA also has a medical marijuana at its location in Northampton and is expected to start its retail operations Tuesday.

"This signal to open retail marijuana establishments marks a major milestone for voters who approved legal, adult-use cannabis in our state," Steven Hoffman, the commission chairman, said in a statement.

The statement was part of a press release that went out at 4:20 p.m. Friday.

"To get here, licensees underwent thorough background checks, passed multiple inspections, and had their products tested, all to ensure public health and safety as this new industry gets up and running," he added.

Hoffman also urged customers to make sure they're familiar with state law on legal marijuana sales and that they consume responsibly.

Sam Barber, the CEO and founder of Cultivate, noted the historic nature of selling the first legal recreational cannabis east of the Mississippi.

"We look forward to selling the highest quality cannabis to consumers and simultaneously be educating the public about how to responsibly enjoy our products," he said in a statement. "We have created dozens of jobs and look forward to creating revenue and contributing positively to state and local region in which we operate."