Advances in additive manufacturing have resulted in significant growth of such materials, including the medical sector. It is particularly applicable to manufacture of prosthetics and implants, where design freedoms and complex geometries afforded by additive manufacturing are especially suited to such products. With this growth it is timely to consider approaches to optimization for both efficiency and performance. In this work a design of experiments approach was used to quantify the effects of build parameters on performance and efficiency outputs. This approach could prove invaluable to designers for both cost and performance optimization, applicable to both prototype and part production.