Consistent old and new data make it clear that the quality and quantity of food, sleep, and exercise matter a lot. We now appreciate that most brain disorders - neurodegenerative diseases, traumatic brain injury, epilepsy, and many more - are intertwined with fundamental problems in cell energy metabolism. And we also know that the nervous system uses more energy than other tissues. Thus, while traditional research has focused on disease-specific mechanisms and drug development, it should come as no surprise that dysfunctional metabolism has a major impact on the dynamic and greedy organ that holds our memories and expresses our emotions, regulates our physical health, and makes decisions to mobilize our actions.