A David Tennant miniseries is set to be adapted for the US – but most likely without its British leads.

The Politician's Husband starred Tennant and Emily Watson as a political golden couple whose relationship turns sour when her career begins to eclipse his.

The series, which originally aired in 2013 on BBC Two, is getting a new name along with the expected new cast for the US transformation.

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Chemistry will be adapted by House of Cards producer David Manson for Showtime and is described by Deadline as "a psycho-sexual marital thriller set in the high stakes world of biotech, focusing on alpha spouses at the head of an emerging firm on the cusp of a life altering discovery."

"It was originally set in politics; we're setting it in biotech because there's a surplus of political shows out there," TriStar TV boss Suzanne Patmore Gibbs said.

"What really attracted us to it was, it is really focused on these alpha spouses that are both in positions of power at this company and what happens in the bedroom and the boardroom when this power shift takes place and the wife's career begins to vastly eclipse that of the husband, and how that changes their relationship in a really integral way.

DayBreak Pictures/Ed Miller BBC

"It's really zeitgeist-y or just pertinent right now in that it's exploring gender politics."

She added that Manson and the producer of the original BBC miniseries, Paula Milne, already know each other and are "going to hopefully collaborate in some way on this version."

There's no word yet on when Chemistry will air or who will play the lead roles.

Tennant recently reprised his role as the Tenth Doctor from Doctor Who in a video skit alongside his wife Georgia, aka the Doctor's daughter – which of course delighted fans.

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