When “The Ellen DeGeneres Show” secured the lineup for its fall premiere week, the executive producers were clearly delighted to land an interview with a guest who has become one of the most talked-about and hotly debated women in the country.

They also booked Hillary Rodham Clinton.

Mrs. Clinton will appear on Ms. DeGeneres’s show two days after Caitlyn Jenner, a former Olympic champion who is transgender.

Typically, an appearance by Mrs. Clinton on a national television show — “Ellen” will be her fifth interview since she declared her candidacy in April — would earn top billing, but “Ellen” is not like other shows. Its warmhearted approach and enormous reach among women make it one of the most sought-after interviews for politicians.

Mrs. Clinton’s aides had long been eager for her to do an interview with Ms. DeGeneres this fall, when voters are paying attention to the election, believing it could humanize her beyond policy speeches and political attacks.