1. Cannon , W ( 1939 ) The Wisdom of the Body . New York : Norton .

2. Richter , C ( 1942 –1943) Total self-regulatory functions of animals and human beings . Harvey Lect Ser 38 , 63 – 103 .

3. Livesey , G ( 1984 ) The energy equivalents of ATP and the energy values of food proteins and fats . Br J Nutr 51 , 15 – 28 .

4. Veldhorst , MA , Westerterp-Plantenga , MS & Westerterp , KR ( 2009 ) Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet . Am J Clin Nutr 90 , 519 – 526 .

5. Kalhan , SC & Kilic , I ( 1999 ) Carbohydrate as nutrient in the infant and child: range of acceptable intake . Eur J Clin Nutr 53 , Suppl. 1, S94 – 100 .

6. Rozin , P ( 1969 ) Adaptive food sampling patterns in vitamin deficient rats . J Comp Physiol Psychol 69 , 126 – 132 .

7. Fromentin , G , Gietzen , DW & Nicolaidis , S ( 1997 ) Aversion-preference patterns in amino acid- or protein-deficient rats: a comparison with previously reported responses to thiamin-deficient diets . Br J Nutr 77 , 299 – 314 .

8. Tindell , AJ , Smith , KS , Berridge , KC et al. ( 2009 ) Dynamic computation of incentive salience: “wanting” what was never “liked” . J Neurosci 29 , 12220 – 12228 .

9. Liedtke , WB , McKinley , MJ , Walker , LL et al. ( 2011 ) Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite . Proc Natl Acad Sci USA 108 , 12509 – 12514 .

10. Berridge , KC , Flynn , FW , Schulkin , J et al. ( 1984 ) Sodium depletion enhances salt palatability in rats . Behav Neurosci 98 , 652 – 660 .

11. Tindell , AJ , Smith , KS , Pecina , S et al. ( 2006 ) Ventral pallidum firing codes hedonic reward: when a bad taste turns good . J Neurophysiol 96 , 2399 – 2409 .

12. Galef , BGJ ( 2000 ) Is There a specific appetite for Protein? In Neural and Metabolic Control of Macronutrient Intake , pp. 19 – 28 [ Berthoud , HR and Seeley , RJ , editors]. Boca Raton, FL : CRC Press .

13. Friedman , M ( 2000 ) Too many choices? Acritical essay on macronutrient selection. In Neural and Metabolic Control of Macronutrient Intake , pp. 11 – 28 [ Berthoud HaS , RJ , editor]. Boca Raton, FL : CRC Press .

14. Simpson , SJ & Raubenheimer , D ( 2000 ) Geometric models of macronutrient selection. In Neural and Metabolic Control of Macronutrient Intake , pp. 29 – 42 [ Berthoud , HR and Seeley , RJ , editors]. Boca Raton, FL : CRC Press .

15. de Castro , JM ( 2000 ) Macronutrient selection in free-feeding humans: evidence for long-term regulation. In Neural and Metabolic Control of Macronutrient Intake , pp. 43 – 59 [ Berthoud , HR and Seeley , RJ , editors]. Boca Raton, FL : CRC Press .

16. Berthoud , HR & Seeley , RJ . ( 2000 ) Neural and Metabolic Control of Macronutrient Intake . Boca Raton, FL : CRC Press .

17. Westerterp-Plantenga , MS , Nieuwenhuizen , A , Tome , D et al. ( 2009 ) Dietary protein, weight loss, and weight maintenance . Annu Rev Nutr 29 , 21 – 41 .

18. Potier , M , Darcel , N & Tome , D ( 2009 ) Protein, amino acids and the control of food intake . Curr Opin Clin Nutr Metab Care 12 , 54 – 58 .

19. Sanahuja , JC & Harper , AE ( 1963 ) Effect of dietary amino acid pattern on plasma amino acid pattern and food intake . Am J Physiol 204 , 686 – 690 .

20. Leung , PM , Rogers , QR & Harper , AE ( 1968 ) Effect of amino acid imbalance on dietary choice in the rat . J Nutr 95 , 483 – 492 .

21. Harper , AE & Peters , JC ( 1989 ) Protein intake, brain amino acid and serotonin concentrations and protein self-selection . J Nutr 119 , 677 – 689 .

22. Koehnle , TJ , Russell , MC & Gietzen , DW ( 2003 ) Rats rapidly reject diets deficient in essential amino acids . J Nutr 133 , 2331 – 2335 .

23. Gietzen , DW , Hao , S & Anthony , TG ( 2007 ) Mechanisms of food intake repression in indispensable amino acid deficiency . Annu Rev Nutr 27 , 63 – 78 .

24. Hao , S , Sharp , JW , Ross-Inta , CM et al. ( 2005 ) Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex . Science 307 , 1776 – 1778 .

25. Rudell , JB , Rechs , AJ , Kelman , TJ et al. ( 2011 ) The anterior piriform cortex is sufficient for detecting depletion of an indispensable amino acid, showing independent cortical sensory function . J Neurosci 31 , 1583 – 1590 .

26. Musten , B , Peace , D & Anderson , GH ( 1974 ) Food intake regulation in the weanling rat: self-selection of protein and energy . J Nutr 104 , 563 – 572 .

27. Cheng , K , Simpson , SJ & Raubenheimer , D ( 2008 ) A geometry of regulatory scaling . Am Nat 172 , 681 – 693 .

28. Simpson , SJ & Raubenheimer , D ( 1997 ) Geometric analysis of macronutrient selection in the rat . Appetite 28 , 201 – 213 .

29. Simpson , SJ & Raubenheimer , D ( 2005 ) Obesity: the protein leverage hypothesis . Obes Rev 6 , 133 – 142 .

30. Kyriazakis , I & Emmans , GC ( 1991 ) Diet selection in pigs: dietary choices made by growing pigs following a period of underfeeding with protein . Anim Prod 52 , 337 – 346 .

31. Raubenheimer , D & Simpson , SJ ( 1997 ) Integrative models of nutrient balancing: application to insects and vertebrates . Nutr Res Rev 10 , 151 – 179 .

32. Sorensen , A , Mayntz , D , Raubenheimer , D et al. ( 2008 ) Protein-leverage in mice: the geometry of macronutrient balancing and consequences for fat deposition . Obesity (Silver Spring) 16 , 566 – 571 .

33. Simpson , SJ , Batley , R & Raubenheimer , D ( 2003 ) Geometric analysis of macronutrient intake in humans: the power of protein? Appetite 41 , 123 – 140 .

34. Gosby , AK , Conigrave , AD , Lau , NS et al. ( 2011 ) Testing protein leverage in lean humans: a randomised controlled experimental study . PLoS ONE 6 , e25929 .

35. Brooks , RC , Simpson , SJ & Raubenheimer , D ( 2010 ) The price of protein: combining evolutionary and economic analysis to understand excessive energy consumption . Obes Rev 11 , 887 – 894 .

36. Mayntz , D , Raubenheimer , D , Salomon , M et al. ( 2005 ) Nutrient-specific foraging in invertebrate predators . Science 307 , 111 – 113 .

37. Bartness , TJ & Rowland , NE ( 1983 ) Diet selection and metabolic fuels in three models of diabetes mellitus . Physiol Behav 31 , 539 – 545 .

38. Epstein , LH , Salvy , SJ , Carr , KA et al. ( 2010 ) Food reinforcement, delay discounting and obesity . Physiol Behav 100 , 438 – 445 .

39. Bellush , LL & Rowland , NE ( 1986 ) Dietary self-selection in diabetic rats: an overview . Brain Res Bull 17 , 653 – 661 .

40. Kanarek , RB & Ho , L ( 1984 ) Patterns of nutrient selection in rats with streptozotocin-induced diabetes . Physiol Behav 32 , 639 – 645 .

41. Tepper , BJ & Kanarek , RB ( 1989 ) Selection of protein and fat by diabetic rats following separate dilution of the dietary sources . Physiol Behav 45 , 49 – 61 .

42. Tordoff , MG , Tepper , BJ & Friedman , MI ( 1987 ) Food flavor preferences produced by drinking glucose and oil in normal and diabetic rats: evidence for conditioning based on fuel oxidation . Physiol Behav 41 , 481 – 487 .

43. Singer , LK , York , DA & Bray , GA ( 1998 ) Macronutrient selection following 2-deoxy- d -glucose and mercaptoacetate administration in rats . Physiol Behav 65 , 115 – 121 .

44. Ritter , S , Ritter , JB & Cromer , L ( 1999 ) 2-Deoxy- d -glucose and mercaptoacetate induce different patterns of macronutrient ingestion . Physiol Behav 66 , 709 – 715 .

45. DiBattista , D ( 1991 ) Effects of time-restricted access to protein and to carbohydrate in adult mice and rats . Physiol Behav 49 , 263 – 269 .

46. White , BD , He , B , Dean , RG et al. ( 1994 ) Low protein diets increase neuropeptide Y gene expression in the basomedial hypothalamus of rats . J Nutr 124 , 1152 – 1160 .

47. Dunlap , S , Heinrichs , SC ( 2009 ) Neuronal depletion of omega-3 fatty acids induces flax seed dietary self-selection in the rat . Brain Res 1250 , 113 – 119 .

48. Gaillard , D , Laugerette , F , Darcel , N et al. ( 2008 ) The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse . FASEB J 22 , 1458 – 1468 .

49. Tracy , AL , Clegg , DJ , Johnson , JD et al. ( 2008 ) The melanocortin antagonist AgRP (83–132) increases appetitive responding for a fat, but not a carbohydrate, reinforcer . Pharmacol Biochem Behav 89 , 263 – 271 .

50. Smith Richards , BK , Belton , BN , York , B et al. ( 2004 ) Mice bearing Acads mutation display altered postingestive but not 5-s orosensory response to dietary fat . Am J Physiol Regul Integr Comp Physiol 286 , R311 – R319 .

51. Toepel , U , Knebel , JF , Hudry , J et al. ( 2009 ) The brain tracks the energetic value in food images . Neuroimage 44 , 967 – 974 .

52. Davidson , TL , Morell , JR & Benoit , SC ( 2000 ) Memory and macronutrient regulation. In Neural and Metabolic Control of Macronutrient Intake , pp. 203 – 217 [ Berthoud , HR and Seeley , RJ , editors]. Boca Raton, FL : CRC Press .

53. Benoit , SC , Davis , JF & Davidson , TL ( 2010 ) Learned and cognitive controls of food intake . Brain Res 1350 , 71 – 76 .

54. Damak , S , Rong , M , Yasumatsu , K et al. ( 2003 ) Detection of sweet and umami taste in the absence of taste receptor T1r3 . Science 301 , 850 – 853 .

55. Palmer , RK ( 2007 ) The pharmacology and signaling of bitter, sweet, and umami taste sensing . Mol Interv 7 , 87 – 98 .

56. Delay , ER , Eddy , MC & Eschle , BK ( 2009 ) Behavioral studies of umami: tales told by mice and rats . Ann NY Acad Sci 1170 , 41 – 45 .

57. Nelson , G , Chandrashekar , J , Hoon , MA et al. ( 2002 ) An amino-acid taste receptor . Nature 416 , 199 – 202 .

58. Chaudhari , N , Pereira , E & Roper , SD ( 2009 ) Taste receptors for umami: the case for multiple receptors . Am J Clin Nutr 90 , 738S – 742S .

59. Maruyama , Y , Pereira , E , Margolskee , RF et al. ( 2006 ) Umami responses in mouse taste cells indicate more than one receptor . J Neurosci 26 , 2227 – 2234 .

60. Perez , C , Ackroff , K & Sclafani , A ( 1996 ) Carbohydrate- and protein-conditioned flavor preferences: effects of nutrient preloads . Physiol Behav 59 , 467 – 474 .

61. Perez , C , Lucas , F & Sclafani , A ( 1995 ) Carbohydrate, fat, and protein condition similar flavor preferences in rats using an oral-delay procedure . Physiol Behav 57 , 549 – 554 .

62. Sclafani , A ( 2001 ) Psychobiology of food preferences . Int J Obes Relat Metab Disord 25 , Suppl. 5, S13 – S16 .

63. Miller , MG & Teates , JF ( 1985 ) Acquisition of dietary self-selection in rats with normal and impaired oral sensation . Physiol Behav 34 , 401 – 408 .

64. DiBattista , D & Mercier , S ( 1999 ) Role of learning in the selection of dietary protein in the golden hamster (Mesocricetus auratus) . Behav Neurosci 113 , 574 – 586 .

65. Zukerman , S , Touzani , K , Margolskee , RF et al. ( 2009 ) Role of olfaction in the conditioned sucrose preference of sweet-ageusic T1R3 knockout mice . Chem Senses 34 , 685 – 694 .

66. Rhinehart-Doty , JA , Schumm , J , Smith , JC et al. ( 1994 ) A non-taste cue of sucrose in short-term taste tests in rats . Chem Senses 19 , 425 – 431 .

67. Nelson , G , Hoon , MA , Chandrashekar , J et al. ( 2001 ) Mammalian sweet taste receptors . Cell 106 , 381 – 390 .

68. Sclafani , A , Glass , DS , Margolskee , RF et al. ( 2010 ) Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice . Am J Physiol Regul Integr Comp Physiol 299 , R1643 – R1650 .

69. Steinert , RE , Gerspach , AC , Gutmann , H et al. ( 2011 ) The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) . Clin Nutr 30 , 524 – 532 .

70. Kokrashvili , Z , Mosinger , B & Margolskee , RF ( 2009 ) Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones . Am J Clin Nutr 90 , 822S – 825S .

71. Laugerette , F , Gaillard , D , Passilly-Degrace , P et al. ( 2007 ) Do we taste fat? Biochimie 89 , 265 – 269 .

72. Kinney , NE & Antill , RW ( 1996 ) Role of olfaction in the formation of preference for high-fat foods in mice . Physiol Behav 59 , 475 – 478 .

73. Ramirez , I ( 1993 ) Role of olfaction in starch and oil preference . Am J Physiol 265 , R1404 – R1409 .

74. Gilbertson , TA , Fontenot , DT , Liu , L et al. ( 1997 ) Fatty acid modulation of K+ channels in taste receptor cells: gustatory cues for dietary fat . Am J Physiol 272 , C1203 – C1210 .

75. Liu , P , Shah , BP , Croasdell , S et al. ( 2011 ) Transient receptor potential channel type M5 is essential for fat taste . J Neurosci 31 , 8634 – 8642 .

76. Cartoni , C , Yasumatsu , K , Ohkuri , T et al. ( 2010 ) Taste preference for fatty acids is mediated by GPR40 and GPR120 . J Neurosci 30 , 8376 – 8382 .

77. Laugerette , F , Passilly-Degrace , P , Patris , B et al. ( 2005 ) CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions . J Clin Invest 115 , 3177 – 3184 .

78. Sclafani , A , Ackroff , K & Abumrad , NA ( 2007 ) CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice . Am J Physiol Regul Integr Comp Physiol 293 , R1823 – R1832 .

79. Matsumura , S , Saitou , K , Miyaki , T et al. ( 2008 ) Mercaptoacetate inhibition of fatty acid beta-oxidation attenuates the oral acceptance of fat in BALB/c mice . Am J Physiol Regul Integr Comp Physiol 295 , R82 – R91 .

80. Ackroff , K , Vigorito , M & Sclafani , A ( 1990 ) Fat appetite in rats: the response of infant and adult rats to nutritive and non-nutritive oil emulsions . Appetite 15 , 171 – 188 .

81. Lucas , F , Ackroff , K & Sclafani , A ( 1989 ) Dietary fat-induced hyperphagia in rats as a function of fat type and physical form . Physiol Behav 45 , 937 – 946 .

82. Ackroff , K , Lucas , F & Sclafani , A ( 2005 ) Flavor preference conditioning as a function of fat source . Physiol Behav 85 , 448 – 460 .

83. Wu , T , Rayner , CK , Jones , K et al. ( 2010 ) Dietary effects on incretin hormone secretion . Vitam Horm 84 , 81 – 110 .

84. Langhans , W , Leitner , C & Arnold , M ( 2011 ) Dietary fat sensing via fatty acid oxidation in enterocytes: possible role in the control of eating . Am J Physiol Regul Integr Comp Physiol 300 , R554 – R565 .

85. Berthoud , HR & Morrison , C ( 2008 ) The brain, appetite, and obesity . Annu Rev Psychol 59 , 55 – 92 .

86. Levin , BE , Magnan , C , Dunn-Meynell , A et al. ( 2011 ) Metabolic sensing and the brain: who, what, where, and how? Endocrinology 152 , 2552 – 2557 .

87. Luquet , S , Perez , FA , Hnasko , TS et al. ( 2005 ) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates . Science 310 , 683 – 685 .

88. Krashes , MJ , Koda , S , Ye , C et al. ( 2011 ) Rapid, reversible activation of AgRP neurons drives feeding behavior in mice . J Clin Invest 121 , 1424 – 1428 .

89. Kelley , AE & Berridge , KC ( 2002 ) The neuroscience of natural rewards: relevance to addictive drugs . J Neurosci 22 , 3306 – 3311 .

90. Berridge , KC ( 1996 ) Food reward: brain substrates of wanting and liking . Neurosci Biobehav Rev 20 , 1 – 25 .

91. Lucas , LR , Pompei , P & McEwen , BS ( 1999 ) Correlates of deoxycorticosterone-induced salt appetite behavior and basal ganglia neurochemistry . Ann NY Acad Sci 897 , 423 – 428 .

92. Cai , XJ , Evans , ML , Lister , CA et al. ( 2001 ) Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract . Diabetes 50 , 105 – 112 .

93. Diano , S , Horvath , B , Urbanski , HF et al. ( 2003 ) Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets . Endocrinology 144 , 3774 – 3778 .

94. Harris , GC , Wimmer , M & Aston-Jones , G ( 2005 ) A role for lateral hypothalamic orexin neurons in reward seeking . Nature 437 , 556 – 559 .

95. Cason , AM , Smith , RJ , Tahsili-Fahadan , P et al. ( 2010 ) Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity . Physiol Behav 100 , 419 – 428 .

96. Mellinkoff , SM , Frankland , M , Boyle , D et al. ( 1956 ) Relationship between serum amino acid concentration and fluctuations in appetite . J Appl Physiol 8 , 535 – 538 .

97. Choi , YH , Chang , N , Fletcher , PJ et al. ( 2000 ) Dietary protein content affects the profiles of extracellular amino acids in the medial preoptic area of freely moving rats . Life Sci 66 , 1105 – 1118 .

98. Hawkins , RA , O'Kane , RL , Simpson , IA et al. ( 2006 ) Structure of the blood-brain barrier and its role in the transport of amino acids . J Nutr 136 , 218S – 226S .

99. Maurin , AC , Jousse , C , Averous , J et al. ( 2005 ) The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores . Cell Metab 1 , 273 – 277 .

100. Russell , MC , Koehnle , TJ , Barrett , JA et al. ( 2003 ) The rapid anorectic response to a threonine imbalanced diet is decreased by injection of threonine into the anterior piriform cortex of rats . Nutr Neurosci 6 , 247 – 251 .

101. Leung , PM & Rogers , QR ( 1971 ) Importance of prepyriform cortex in food-intake response of rats to amino acids . Am J Physiol 221 , 929 – 935 .

102. Blouet , C , Jo , YH , Li , X et al. ( 2009 ) Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit . J Neurosci 29 , 8302 – 8311 .

103. Cota , D , Proulx , K , Smith , KA et al. ( 2006 ) Hypothalamic mTOR signaling regulates food intake . Science 312 , 927 – 930 .

104. Morrison , CD , Xi , X , White , CL et al. ( 2007 ) Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism . Am J Physiol Endocrinol Metab 293 , E165 – E171 .

105. Ropelle , ER , Pauli , JR , Fernandes , MF et al. ( 2008 ) A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss . Diabetes 57 , 594 – 605 .

106. Morrison , CD , White , CL , Wang , Z et al. ( 2007 ) Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age . Endocrinology 148 , 433 – 440 .

107. Purpera , MN , Shen , L , Taghavi , M et al. ( 2012 ) Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus . J Endocrinol 212 , 85 – 94 .

108. Newgard , CB , An , J , Bain , JR et al. ( 2009 ) A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance . Cell Metab 9 , 311 – 326 .

109. Blevins , JE , Truong , BG & Gietzen , DW ( 2004 ) NMDA receptor function within the anterior piriform cortex and lateral hypothalamus in rats on the control of intake of amino acid-deficient diets . Brain Res 1019 , 124 – 133 .

110. Elias , CF , Saper , CB , Maratos-Flier , E et al. ( 1998 ) Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area . J Comp Neurol 402 , 442 – 459 .

111. Berthoud , HR & Mogenson , GJ ( 1997 ) Ingestive behavior after intracerebral and intracerebroventricular infusions of glucose and 2-deoxy- d -glucose . Am J Physiol 233 , R127 – R133 .

112. Bady , I , Marty , N , Dallaporta , M et al. ( 2006 ) Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding . Diabetes 55 , 988 – 995 .

113. Woods , SC , Lotter , EC , McKay , LD et al. ( 1979 ) Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons . Nature 282 , 503 – 505 .

114. Chavez , M , Riedy , CA , Van Dijk , G et al. ( 1996 ) Central insulin and macronutrient intake in the rat . Am J Physiol 271 , R727 – R731 .

115. Lenoir , M , Serre , F , Cantin , L et al. ( 2007 ) Intense sweetness surpasses cocaine reward . PLoS ONE 2 , e698 .

116. Hajnal , A , Smith , GP & Norgren , R ( 2004 ) Oral sucrose stimulation increases accumbens dopamine in the rat . Am J Physiol Regul Integr Comp Physiol 286 , R31 – R37 .

117. Sclafani , A , Touzani , K & Bodnar , RJ ( 2011 ) Dopamine and learned food preferences . Physiol Behav 104 , 64 – 68 .

118. Tempel , DL , Leibowitz , KJ & Leibowitz , SF ( 1988 ) Effects of PVN galanin on macronutrient selection . Peptides 9 , 309 – 314 .

119. Clegg , DJ , Air , EL , Woods , SC et al. ( 2002 ) Eating elicited by orexin-a, but not melanin-concentrating hormone, is opioid mediated . Endocrinology 143 , 2995 – 3000 .

120. Wortley , KE , Chang , GQ , Davydova , Z et al. ( 2003 ) Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia . Am J Physiol Regul Integr Comp Physiol 284 , R1454 – R1465 .

121. Chang , GQ , Karatayev , O , Ahsan , R et al. ( 2007 ) Dietary fat stimulates endogenous enkephalin and dynorphin in the paraventricular nucleus: role of circulating triglycerides . Am J Physiol Endocrinol Metab 292 , E561 – E570 .