THE wife of Republican presidential candidate Ted Cruz has responded to claims her husband is the infamous Zodiac Killer.

The conspiracy of Cruz being the serial killer responsible for a series of unsolved murders during the late 1960s and early 1970s began in 2013 after he delivered a speech titled ‘This is the Zodiac Speaking’.

Since the speech, the internet has gone crazy with memes suggesting Cruz is the Zodiac Killer - despite the small fact he was born only two years after the first murder.

Proof that Ted Cruz is the Zodiac Killer. (Vine by @rickyftw) https://t.co/DkW43COwty — ChefGod (@ChefGod_) April 10, 2016

Here you can see a photo of Ted Cruz next to a photo of the infamous Zodiac Killer. This can't be a coincidence. pic.twitter.com/XJuNfIMdZU — C (@CorCorMac) January 20, 2016

The ongoing joke has become so popular, Comedy Central host Larry Wilmore made a series of wisecracks about Ted Cruz being the Zodiac Killer at White House Correspondents’ dinner on Saturday night.

“Recently, Ted Cruz got a string of wins and endorsements. Then everybody remembered who Ted Cruz is — the Zodiac Killer,” he said.

While travelling across Indiana in support of her husband’s presidential campaign, Heidi Cruz was asked her thoughts about the claims.

“I’ve been married to him for 15 years, and I know pretty well who he is, so it doesn’t bother me at all. There’s a lot of garbage out there,” she toldYahoo.

Ms Cruz added she was surprised by how far the rumour had spread.

“It’s amazing how a lot of people are swayed by it,” she said.

“Part of it is, the news media is 24/7, and they don’t let up.”

Despite Ms Cruz’s strong rebuttal, the internet is not completely sold with her explanation.

So Ted Cruz's wife came out and said that he isn't the Zodiac Killer? Sounds like something the Zodiac Killer's wife would say. — Josh Vaughn (@jjvaughny) May 2, 2016

@mmegannnolan Zodiac Killer's Wife: My husband is Ted Cruz. — The Postdoc Desirer (@HealthUntoDeath) May 2, 2016

Ms Cruz isn’t the first to try and cover the tracks of Ted Cruz’s murderous past, with Google removing the ‘Is Ted Cruz the Zodiac Killer’ suggestion, despite it being most popular search.