Rams coach Jeff Fisher said former NFL and University of Cincinnati running back Isaiah Pead's playing career is over as a result of the injuries he sustained in a car crash in Columbus, Ohio.

Pead was critically injured in a single-car accident on Saturday, when he drove off the side of Interstate 670 in Columbus. Sheriff's officers told NBC4 that Pead lost control of his vehicle at approximately 2:32 a.m. Saturday morning.

Pead was ejected from the vehicle, while a passenger, Wesley Richardson, 27, was in stable condition, according to the crash report. Police said drugs and alcohol were not a factor in the crash.

"Our organization's hearts and prayers go out to the Isaiah Pead family," Fisher said of Pead, who spent his four years in the NFL with the Rams from 2012 to 2015 and the Dolphins this season. "I spoke with his mom [on Saturday]. He's struggling, and he's going to have a tough road. We're hoping that he'll come through this, but his career is over, and he was an outstanding young man while we had him."

A Columbus native, Pead was a second-round draft pick of the Rams in 2012, after starring at Cincinnati.

Running back Isaiah Pead, who recently worked out for the Chiefs after being released by the Dolphins last month, is in critical condition after a car accident. Jerome Miron/USA TODAY Sports

"It's hard on him and his family, because he's going to have a tough life in front of him," Cincinnati coach Tommy Tuberville said on Tuesday, as quoted in the Cincinnati Enquirer. "Our prayers go out to him. Tough situation to a great kid, and a great Bearcat."

Tuberville said Cincinnati football trainer Bob Mangine visited Pead in the hospital on Tuesday and added that the school had sent Pead a Bearcats jersey.

"[Pead] still works out here quite a bit," Tuberville said. "I've gotten to know him real well. Just a great person."