Fire has ripped through an inner-city cafe, likely causing tens of thousands of dollars in damage and shutting nearby businesses.

The blaze broke out at Caffe Boulevard, in Spring Hill, about 4.35am Monday morning and took firefighters about an hour to get under control.

The blaze broke out at Caffe Boulevard just after 4.30am. Credit:Nine News

Station officer Troy Hartley said seven crews arrived to find smoke and flames pouring out of the Upper Edward Street business, prompting concerns the fire could spread.

He said the family-owned cafe itself was extensively damaged and smoke had spread through nearby premises, including and IGA X-Press, video game shop, bakery and a Domino's.