I just found this pic on my hard drive from a year or so ago, and laughed at it again. Forgive me for not remembering the (pictured) Sheldon reader who submitted it, but it's probably the best use of this Sheldon shirt I've ever seen.

As a side note: We should have a contest at some point for the funniest/best use of a Sheldon shirt in a photo. You guys would probably be awesome in a contest like that. The intensity is what cracks me up: Totally sells the moment.