End-stage liver disease (ESLD) is the 8th leading cause of death in the United States, accounting for 40,000 deaths annually. The only curative therapy for ESLD is liver transplantation. Unfortunately, the success of liver transplantation has led to its greatest challenge, the shortage of available organs. Nationally, about 16,000 patients per year are waiting for liver transplantation. Two-thirds won’t receive a liver. We can change that.