Episode: "The Show Must Go On" (Season 3, Episode 22)

Fun fact: This scene was one of the first times a Led Zeppelin song had been licensed for network television! The chaotic guitar chords and the shrieking of Robert Plant make the season three closer an unforgettable one as it reflects the tumultuous nature of the lives of everyone in Tree Hill: Dan discovers someone knows his darkest secret, Peyton and Brooke are no longer friends, someone is unexpectedly pregnant, Rachel and Cooper crash the limo into a river, Nathan dives in after them, and Haley is screaming her head off. This scene definitely would not have had the same effect without this song, and isn't that what makes the best music moment? (Second fun fact: You will never be able to watch this scene without getting chills.)