REBEL Cast Episode 18: Our Top 5 AHA 2015 Guideline Updates for CPR and ECC

In case you have not heard or not read it on the twittersphere, the American Heart Association just released their 2015 Guidelines Update for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC) in Circulation. I am joined by Mr. Security, Matt Astin for this episode and we both read through this massive 15 part document and came up with our top 5 updates and recommendations. Now this is just a list of our top 5 new or updated recommendations, that caught our attention, but certainly there are other recommendations. If you want the cliff notes version of the updates look through part I, titled the executive summary or the Highlights PDF which we will attach on the blog, but certainly as always we recommend reading the full document to form your own interpretations and opinions.

REBEL Cast Episode 18: Our Top 5 AHA 2015 Guideline Updates for CPR and ECC

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AHA Strength of Recommendation and Quality of Evidence

Our Top 5 AHA 2015 Guideline Updates for CPR and ECC

Vasopressin is Out (Part 7: Adult Advanced Cardiovascular Life Support, S451): The AHA has determined that Vasopressin offers no advantage as either a substitute for or in combination with standard-­‐dose epinephrine in cardiac arrest (ClassIIb, LOE B-­‐R). The old 2010 recommendation was one dose of vasopressin 40U IV or IO could be used as a replacement either as a first or second dose for epinephrine in the treatment of cardiac arrest. Both Vasopressin and Epinephrine have been shown to increase ROSC in OHCA, and the best available evidence shows that the efficacy of the 2 drugs to achieve this is similar. Therefore for the sake of simplicity the AHA decided to remove Vasopressin from the ACLS algorithm. Some may argue that the Vasopressin, Steroid, Epinephrine Study (Mentzelopoulos SD et al) may argue against this recommendation. First this was a study of IHCA not OHCA. In IHCA the recommendation is the combined use of epinephrine, steroid, and vasopressin MAY BE considered, but further studies are needed before the routine use of this strategy can be recommended (ClassIIb, LOE C-­‐LD).

The AHA has determined that Vasopressin offers no advantage as either a substitute for or in combination with standard-­‐dose epinephrine in cardiac arrest (ClassIIb, LOE B-­‐R). The old 2010 recommendation was one dose of vasopressin 40U IV or IO could be used as a replacement either as a first or second dose for epinephrine in the treatment of cardiac arrest. Both Vasopressin and Epinephrine have been shown to increase ROSC in OHCA, and the best available evidence shows that the efficacy of the 2 drugs to achieve this is similar. Therefore for the sake of simplicity the AHA decided to remove Vasopressin from the ACLS algorithm. Some may argue that the Vasopressin, Steroid, Epinephrine Study (Mentzelopoulos SD et al) may argue against this recommendation. First this was a study of IHCA not OHCA. In IHCA the recommendation is the combined use of epinephrine, steroid, and vasopressin MAY BE considered, but further studies are needed before the routine use of this strategy can be recommended (ClassIIb, LOE C-­‐LD). Acute Coronary Syndrome Risk Stratification (Part 9: Acute Coronary Syndrome, S485): The updated recommendations state that a negative cTnI or cTnT measurement at 0 and between 3 – 6 hours may be used together with very low-­‐risk stratification strategy (i.e. TIMI Score = 0, Low-­‐Risk Score per Vancouver Rule, North American Chest Pain Score = 0 and age <50years, or a low-­‐risk HEART Score = 0 – 3) in order to predict a <1% chance of 30-­‐ day MACE (ClassIIa, LOE B-­‐NR). The 2010 recommendation was that if biomarkers are initially negative within 6 hours of symptom onset, it was recommended that biomarkers should be remeaasured between 6 – 12 hours after symptom onset.

The updated recommendations state that a negative cTnI or cTnT measurement at 0 and between 3 – 6 hours may be used together with very low-­‐risk stratification strategy (i.e. TIMI Score = 0, Low-­‐Risk Score per Vancouver Rule, North American Chest Pain Score = 0 and age <50years, or a low-­‐risk HEART Score = 0 – 3) in order to predict a <1% chance of 30-­‐ day MACE (ClassIIa, LOE B-­‐NR). The 2010 recommendation was that if biomarkers are initially negative within 6 hours of symptom onset, it was recommended that biomarkers should be remeaasured between 6 – 12 hours after symptom onset. Using Social Media to Summon Rescuers (Part 4: Systems of Cared and Continuous Quality Improvement, S404): Given the low risk of harm and the potential benefit of such notifications, it may be reasonable for communities to incorporate, where available, social media technologies that summon rescuers who are willing and able to perform CPR and are in close proximity to a suspected victim of OHCA (Class IIb, LOE B-­‐R). This is a new recommendation, but one that I support. There is currently a free app called the goodsamapp. SAM stands for Smartphone Activated Medics. You can read more about it at goodsamapp.org. This free app lets you open the app and call for help which will call 911 but at the same time will send out alerts to nearby registered users who can open airways perform CPR and use a defibrillator if need be. We all know that early CPR and early defibrillation are keys to survival and good neurologic outcomes in cardiac arrest. Now I should say that there is no study that has shown that activation with social media improves survival from OHCA, but it has been shown to increase the rate of bystander-­‐initiated CPR.

Given the low risk of harm and the potential benefit of such notifications, it may be reasonable for communities to incorporate, where available, social media technologies that summon rescuers who are willing and able to perform CPR and are in close proximity to a suspected victim of OHCA (Class IIb, LOE B-­‐R). This is a new recommendation, but one that I support. There is currently a free app called the goodsamapp. SAM stands for Smartphone Activated Medics. You can read more about it at goodsamapp.org. This free app lets you open the app and call for help which will call 911 but at the same time will send out alerts to nearby registered users who can open airways perform CPR and use a defibrillator if need be. We all know that early CPR and early defibrillation are keys to survival and good neurologic outcomes in cardiac arrest. Now I should say that there is no study that has shown that activation with social media improves survival from OHCA, but it has been shown to increase the rate of bystander-­‐initiated CPR. CPR Quality (Part 5: Adult Basic Life support and Cardiopulmonary Resuscitation Quality, S419 – 420): In 2010 the old adage of ABCs was changed to CABs to focus on circulation early. The key to good neurologic survival is good CPR. There is no surprise that in the 2015 update there is huge emphasis on the quality of CPR. The key amendments made are: Rate: In adult victims of cardiac arrest, it is reasonable for rescuers to perform chest compressions at a rate of 100/min to 120/min (Class IIa, LOE C-­‐LD). The 2010 recommendation stated it was reasonable for lay rescuers and health care providers to perform chest compressions at a rate of at least 100/min. It turns out the number of chest compressions delivered per minute during CPR is an important determinant of ROSC and survival with good neurologic function. This number is dependent on two factors: rate of compressions and duration of interruptions. Either an inadequate compression rate or frequent interruptions (or both) will reduce the total number of compressions delivered per minute. Another key to remember is that an upper limit to compression rate is recommended in 2015 because excessive compression rate can adversely affect patient outcomes. Depth: During manual CPR rescuers should perform chest compressions to a depth of a at least 2 inches or 5 cm for an average adult, while avoiding excessive chest compression depths (greater than 2.4 inches or 6 cm) (Class I, LOE C-­‐LD). The 2010 recommendation was the adult sternum should be depressed at least 2 inches (5cm). Now my issue with this is, in a code situation when we are asking to push “hard and fast,” how do we judge the depth of compressions without the use of some sort of feedback device? Recoil: It is reasonable for rescuers to avoid leaning on the chest between compressions to allow full chest wall recoil for adults in cardiac arrest (Class IIa, LOE C-­‐LD). There are no human trial reporting the relationship between chest wall recoil and clinical outcomes. The evidence for this is derived from 2 small animal studies and a pediatric study of patients not in cardiac arrest. In all three of these studies, incomplete recoil was associated with a dose-­‐ dependent decrease in coronary perfusion pressure. Minimizing Interruptions: In adult cardiac arrest, total preshock and postshock pauses in chest compressions should be as short as possible (Class I, LOE C-­‐LD). For adults in cardiac arrest receiving CPR without an advanced airway, it is reasonable to pause compressions for less than 10 seconds to deliver 2 breaths (Class IIa, LOE C-­‐LD). In adult cardiac arrest with an unprotected airway, it may be reasonable to perform CPR with the goal of a chest compression fraction as high as possible, with a target of at least 60% (Class IIb, LOE C-­‐LD). There are several observational trials that show the duration of compression interruption for the perishock period is directly related to outcomes. The shorter this time is the greater the likelihood of shock success, ROSC, and survival to hospital discharge. So minimize all interruptions in CPR, but really focus on the perishock time period.

In 2010 the old adage of ABCs was changed to CABs to focus on circulation early. The key to good neurologic survival is good CPR. There is no surprise that in the 2015 update there is huge emphasis on the quality of CPR. The key amendments made are:

Using ETCO2 to End Resuscitative Efforts (Part 7: Adult Advanced Cardiovascular Life Support, S453): In intubated patients, failure to achieve an ETCO2 of greater than 10 mm Hg by waveform capnography after 20 minutes of CPR may be considered as one component of a multimodal approach to decide when to end resuscitative efforts, but it should not be used in isolation (Class IIb, LOE C-­‐LD). The above recommendation is made with respect to ETCO2 in patients who are intubated, because the studies examined included only those who were intubated. Studies on the predictive capacity of ETCO2 among intubated patients during cardiac arrest resuscitation are observational, and none have investigated survival with intact neurologic outcome. It is important to remember in observational studies there could be confounding factors not taken into account. Also, the relatively small numbers of patients in these studies suggest that ETCO2 should not be used alone as an indication to terminate resuscitative efforts, but, the failure to achieve an ETCO2 greater than 10 mmHg despite optimized resuscitation efforts may be a valuable component of a multimodal approach to deciding when to terminate resuscitation (i.e. point of care ultrasound with no cardiac activity).

Summary of Our Top 5 AHA 2015 Guideline Updates for CPR and ECC

Vasopressin is no longer recommended in OHCA In Acute Coronary Syndrome you can predict a <1% chance of 30-day MACE using a low risk stratification strategy plus contemporary troponins at 0 and 3 hours from arrival Sign up for the good SAM app…you may just save a life Focus on CPR quality: Rate: 100 – 120/min Depth: Between 2 in (5cm) and 2.5in (6cm) Allow full recoil of the chest between compressions Minimize Interruptions Consider using ETCO2 in conjunction with other tools to help in making the tough decision of when to end resuscitative efforts in cardiac arrest

REBEL EM Teaser

We didn’t cover mechanical CPR on this podcast, but we have a blog post coming out on October 26th about the utility of mechanical CPR vs Manual CPR in OHCA. STAY TUNED!!!!

We Want to Hear from You

We Would Love to Hear From You: What are your best highlights from the new recommendations. Just leave them in the comments section of the blog post.

References:

Neumar RW et al. Part 1: Executive Summary: 2015 American Heart Assocition Guideline Update for Cardiopulmonary Resuscitation and Emergency Cardriovascular Care. Circulation 2015; 132(18 Suppl 2): S315 – 67. [epub ahead of print] PMID: 26472989 Highlights of the 2015 American Heart Association Guidelines Update for CPR and ECC. [PDF] Mentzelopoulos SD et al. Vasopressin, Steroids, and Epinephrine and Neurologically Favorable Survival After In-Hospital Cardiac Arrest: A Randomized Clinical Trial. JAMA 2013; 310(3): 270 – 9. PMID: 23860985 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation (CPR) and Emergency Cardiovascular Care (ECC). Circulation 2015 Table of Contents

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Post Peer Reviewed By: Matt Astin (Twitter: @mastinmd)