A tractor has ploughed into a home at Lyndhurst, south-east of Melbourne, injuring a couple asleep in bed at the time.

The driver fled the scene and police believe the tractor, which had a load of seedlings on the back, was stolen.

A 34-year-old man and a 41-year-old woman were in their bedroom when the tractor smashed into the house on Castawellan Street around 12:45am.

Sergeant Adam Ferguson from Victoria Police said it was an unusual situation and the couple were extremely lucky.

"It appears it's a tractor from a market garden around the corner, and possibly kids joy-riding and have lost control and it's gone into the front bedroom," Sergeant Ferguson said.

"It's quite surprising the two people have survived. They were lying in bed and the tractor pushed them up against the back wall.

One of the tractor's wheels ended up on the couple's bed. ( ABC News )

"It's a big John Deere tractor that probably weighs 30 or 40 tonnes and it's pretty much ended up lying on top of them.

"It's one we haven't seen [before]."

The couple suffered minor injuries and were taken to Dandenong Hospital.

A 14-year-old boy and a 17-year-old girl were asleep at the other end of the house and were not injured.

Police believe the driver jumped from the tractor prior to the crash and ran from the scene.

A search of the area was conducted by local police but they were unable to find the person responsible.