Ginger (Zingiber Officinale Roscoe) is a plant that is used as a popular spice in foods, desserts and drinks all around the world. This plant is native to Asia and has been used since ancient times in the prevention and treatment of many diseases. To date, several properties of ginger such as antioxidant, anti-inflammatory and anticoagulation activities have been studied and the effect of the plant to reduce pain and improve nausea and vomiting has been established. Among human and animal studies that have been carried out in recent years on the properties of ginger, some literature aimed to investigate the effect of this plant on blood lipids. In this review, we consider those studies and their possible enzymatic and molecular mechanisms regarding the effect of ginger on lipid profiles.