SAN JOSE — A car that led a late-night high-speed freeway chase from San Jose to Pleasanton — ending with five arrests and a handgun getting tossed out the window — was sought in connection with a deadly weekend drive-by shooting in San Jose, authorities said.

The Monday night vehicle pursuit involving San Jose police and the California Highway Patrol started about 90 minutes after another shooting south of downtown San Jose, at the vigil memorializing 20-year-old Juan Luna, who was shot and killed early Saturday.

San Jose police announced Tuesday the preliminary investigation into the homicide “revealed indications the shooting was gang related.” The area has been long known as a stronghold for Sureño street gangs.

In response, the city has initiated its crisis response protocol headed by the Mayor’s Gang Prevention Task Force, where gang intervention specialists head out to the affected neighborhoods to head off retaliation. SJPD has also increased its deployment of gang patrols. Officials have not confirmed Monday’s shooting at the vigil site was gang-related, but sources with expertise in the gang tensions of the area say it is likely.

Around 11 p.m. Monday, San Jose police officers spotted a Ford Fusion that matched the description of a vehicle involved in the drive-by that killed Luna at South Almaden Avenue and Oak Street. They started trailing the car at Story Road and Capitol Expressway in East San Jose and followed it onto northbound Interstate 680, where officers reported seeing a handgun being thrown from the vehicle near the Washington Boulevard exit in Fremont.

CHP officers took over the chase, which reached speeds of up to 100 mph before the Ford Fusion blew its rear-left tire, after which the driver pulled over to the center divider north of Bernal Road.

All five occupants were taken into custody, and the vehicle was impounded. San Jose police recovered the handgun on the freeway shoulder near where it was seen getting tossed from the car.

Details about the car’s occupants were not immediately released. They were being interrogated Tuesday morning.

The homicide occurred around 2 a.m. Saturday and ended with the death of Luna and the wounding of a second man. It was San Jose’s fifth homicide of the year.

Anyone with information about the Luna case can contact SJPD homicide detectives at 408-277-5283 or leave a tip with Silicon Valley Crime Stoppers at 408-947-STOP (7867) or with svcrimestoppers.org.

Contact Robert Salonga at rsalonga@mercurynews.com. Contact Mark Gomez at mgomez@mercurynews.com.