Rodriguez hit a two-run homer to straightaway center field in the first inning of a game against the Toronto Blue Jays, off Shaun Marcum. It came on a 2-0 pitch over the middle of the plate with Derek Jeter on first and two out.

At 35 years, 8 days, Rodriguez became the youngest player in history to join the 600 Club, and the seventh player in baseball history to reach the milestone.

He raised a hand slightly in triumph as he rounded first base, then completed his home run trot. He joined an elite club that includes Barry Bonds (762), Henry Aaron (755), Babe Ruth (714), Willie Mays (660), Ken Griffey Jr. (630) and Sammy Sosa (609). After Rodriguez, the next-youngest member of the 600 Club is its first -- Ruth, at 36 years, 196 days.

"[I'm] definitely glad it's over and I definitely enjoyed that moment and enjoyed the win," he said after the game, a 5-1 Yankees victory that prevented a Toronto three-game series sweep. "We needed a win today ... we needed to stop the bleeding a little bit. That's a very good team over there."

Of the seven players with 600 homers, Rodriguez's 46 at-bats between No. 599 and No. 600 were the longest. His 600th homer ended a 12-game homerless slump and came exactly three years to the day after his 500th homer.

Entering Thursday's game, Rodriguez was 4-for-17 against Marcum with one career homer off the right-hander.

Rodriguez's 17th homer of the season sailed over the center-field wall and landed in Monument Park. The ball was retrieved by a Yankees security guard and will be returned to Rodriguez.

As he rounded the bases, he was treated to a standing ovation from the crowd at Yankee Stadium. After he touched home plate he was embraced by Jeter, who had scored ahead of him, and by the next batter, Robinson Cano.

All of Rodriguez's teammates -- many of whom had raised their arms in joy when he finally connected -- then came out of the dugout to embrace him. After they had all retreated to the dugout, Rodriguez returned for his own curtain call.

"Congratulations to Alex on this great achievement and on adding another highlight to Yankees history. We are especially proud he accomplished this feat as a Yankee and here before the most loyal fans in baseball," team co-owner Hal Steinbrenner said of the achievement.

Rodriguez had gone 46 at-bats between home runs Nos. 599 and 600 -- 25 more than Willie Mays, who needed 21 at-bats to reach the milestone in 1970.

Asked if he thought the ball would clear the fence, he said he wasn't sure.

Alex Rodriguez ended a 46 at-bat homerless skid to reach the 600 Club on Wednesday. Michael Heiman/Getty Images

"It sure has been awhile, but it definitely felt good to get a big home run and help us win," he said.

"I just wanted to get a base hit," he added. "My teammates wanted me to go out there and relax."

The Yankees immediately informed fans that a special program and T-shirt were available to commemorate A-Rod's achievement. One stand behind home plate sold out within two innings.

A-Rod hit his 599th off Robinson Tejeda of the Kansas City Royals last Thursday at Yankee Stadium. The ball he hit was the 104th specially marked one that had been used for each of his plate appearances since reaching No. 599.

The longest homerless streak of his career came in 1994 and 1995, when he was a young, skinny kid with the Mariners and went 102 at-bats without a home run.

As a Yankee, he had a 72 at-bat homerless streak last year and a 61 at-bat stretch earlier this season.

A-Rod turned 35 last Tuesday, putting his home run pace far ahead of the rest. Ruth had been the youngest to hit 600; the Sultan of Swat did it in fewer games, though -- 2,044 to 2,227 for Rodriguez.

In the three years since he hit No. 500, much has changed for him.

During a tumultuous spring training of 2009, Rodriguez admitted to using steroids while playing for the Texas Rangers from 2001 to '03. He also had major hip surgery that kept him out the first month last year, as the team adjusted to high-profile newcomers CC Sabathia, A.J. Burnett and Mark Teixeira without him.

He returned with a fresh outlook that put the team first, helping lead the Yankees to their first World Series championship since 2000 and reversing a trend of personal playoff failures.