President Trump Donald John TrumpSteele Dossier sub-source was subject of FBI counterintelligence probe Pelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Trump 'no longer angry' at Romney because of Supreme Court stance MORE's personal attacks on women are fueling GOP fears that the party may lose suburban female voters in November.

The president's latest insult — aimed at adult-film actress Stormy Daniels — comes just three weeks before the midterm elections and right on the heels of a bruising confirmation battle over Supreme Court Justice Brett Kavanaugh Brett Michael KavanaughTrump faces tricky choice on Supreme Court pick The Hill's 12:30 Report: Trump stokes fears over November election outcome The Hill's Morning Report - Sponsored by Facebook - Trump previews SCOTUS nominee as 'totally brilliant' MORE.

Republican lawmakers were quick to condemn Trump's offensive remarks calling Daniels “Horseface.”

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“There is no place for that kind of language … he should not have said that,'' Speaker Paul Ryan Paul Davis RyanKenosha will be a good bellwether in 2020 At indoor rally, Pence says election runs through Wisconsin Juan Williams: Breaking down the debates MORE (R-Wis.), who is usually measured in his criticism of the president, told CBS on Wednesday.

Rep. Chris Stewart Christopher (Chris) Douglas StewartAtlanta Wendy's 911 call the night of Rayshard Brooks's death released Tyler Perry offers to pay for funeral of Rayshard Brooks Current, former NHL players form diversity coalition to fight intolerance in hockey MORE (R-Utah) called the attack “unpresidential” and “rude,” lamenting that Trump’s behavior on Twitter undermines the GOP’s accomplishments.

At the same time, some question whether the attacks matter in the Trump era. Trump repeatedly attacked the physical appearance of his female adversaries during the 2016 presidential race and still won the White House, skeptics note.

“It's just another tweet in an ongoing pattern,” said GOP strategist Liz Mair. “When you constantly behave in an outrageous fashion, people get immunized and numb to that.”

There’s no doubt that Republicans would prefer to talk about the economy, jobs and taxes in the final campaign stretch rather than fielding questions from local reporters about what they think of Trump’s remark about Daniels.

The tweet came a day after a federal judge threw out a defamation suit from the adult-film actress, who alleges she had an affair with Trump in 2006. The judge ordered her to pay Trump’s legal fees.

Dealing with questions about the president’s comments is nothing new for Republicans on the campaign trail. The “horseface” remark is just the latest in a string of crude and sometimes racially tinged attacks that the president has lobbed at women.

Trump has called former White House aide Omarosa Manigault Newman Omarosa Onee Manigault NewmanTrump hurls insults at Harris, Ocasio-Cortez and other women Pelosi makes fans as Democrat who gets under Trump's skin The Memo: Impeachment's scars cut deep with Trump, say those who know him MORE a “dog,” labeled Rep. Maxine Waters Maxine Moore WatersPowell, Mnuchin stress limits of current emergency lending programs Pelosi: House will stay in session until agreement is reached on coronavirus relief Omar invokes father's death from coronavirus in reaction to Woodward book MORE (D-Calif.) as “extraordinarily low-IQ,” described an ex-Miss Universe as “Miss Piggy” and branded Sen. Elizabeth Warren Elizabeth WarrenHillicon Valley: Subpoenas for Facebook, Google and Twitter on the cards | Wray rebuffs mail-in voting conspiracies | Reps. raise mass surveillance concerns On The Money: Anxious Democrats push for vote on COVID-19 aid | Pelosi, Mnuchin ready to restart talks | Weekly jobless claims increase | Senate treads close to shutdown deadline Democratic senators ask inspector general to investigate IRS use of location tracking service MORE (D-Mass.) “Pocahontas” in reference to her claims of Native American heritage.

Even Republicans who support Trump’s policies are deeply frustrated with his rhetoric, which they worry will further push away moderate and independent women from the party. Even if voters annoyed by Trump’s comments don’t vote for Democrats, they may feel so fed up with the nasty political climate that they will just sit out the election all together.

“I really wish he’d stop tweeting. We’re two and a half weeks out [from the midterm elections],” said Sarah Chamberlain, president and CEO of the Republican Main Street Partnership. “I would hope he puts down his phone and focuses on the issues and keeps doing his job.”

Republicans are defending dozens of vulnerable seats this fall, many of which are in suburban swing districts, where college-educated women are expected to form a crucial voting bloc.

And there are signs that the GOP may be in serious trouble with women who hold college degrees.

The group narrowly went for Democratic presidential nominee Hillary Clinton Hillary Diane Rodham ClintonFox News poll: Biden ahead of Trump in Nevada, Pennsylvania and Ohio Trump, Biden court Black business owners in final election sprint The power of incumbency: How Trump is using the Oval Office to win reelection MORE in 2016, but a recent Washington Post–Schar School survey shows that college-educated white women in key battleground races favor Democrats over Republicans by a whopping 27-point margin.

“This targeted group of suburban women voters has been over this guy for a pretty long time,” Mair said. “But women don’t like being insulted in terms of their appearance, and so this is gonna hit some deeper emotional note.”

Trump repeatedly came under fire for his treatment of women during the 2016 campaign, particularly after the release of the “Access Hollywood” tape where he can be heard talking vulgarly about how his fame lets him get away “with anything” when it comes to women.

Weeks after the release of the tape, however, 52 percent of white women voted for Trump and not Clinton, the first woman to be a major party’s candidate for president, according to exit polls.

Some strategists point out that the political environment is much different today.

The national “Me Too” movement has inspired a record number of women to run for office and has fired up female voters, who could power a blue wave in November if Republicans fail to win enough of them over.

Strategists say that independent and moderate women are not monolithic, however, and some might have stronger feelings about Trump's tweets than others. The most competitive races are taking place in a diverse range of American suburbs, including in Texas, Illinois, California and Pennsylvania.

While most females will likely find the “horseface” insult inappropriate, some women will vote more on their policy preferences than their personal feelings toward the president, according to Chamberlain.

The Republican Main Street Partnership, which has conducted a number of focus groups with women, has found that female voters generally tend to care most about “kitchen table” issues like health care, safety and education.

“They like his policies — they don't like the tweets,” Chamberlain said.

On Wednesday, Trump fired off another tweet aimed at women — this time, pushing back against the idea that he is exacerbating the GOP’s problem with college-educated female voters.

“College educated women want safety, security and healthcare protections — very much along with financial and economic health for themselves and our Country,” Trump tweeted. “I supply all of this far better than any Democrat (for decades, actually). That’s why they will be voting for me!”