Bernie Sanders has won Colorado, earning him his second victory among Super Tuesday states set to determine the Democratic nominee to face Donald Trump in November.

The Vermont Senator secured the state in 2016, when he beat Hillary Clinton by 19 points. This year, the state moved from a caucus to an open primary system, aiming to cast a wider net among voters

The state holds 67 delegates.

Nearly 16 per cent of the state's voting population is Latino, and nearly half of those voters are millennials, who the Sanders campaign has relied on as it looks to the West.

Colorado's Democratic Party estimates that Latinos could represent one out of every five voters.

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It's the first time in two decades that the state is not relying on a caucus system to select a candidate. Mail-in ballots for the Democratic and Republican presidential primaries were sent out last month and were due on Super Tuesday.

With voting open for several weeks, last-minute dropouts from former contenders Pete Buttigieg and Amy Klobuchar, as well as Tom Steyer, could affect the final tallies, as a final surge of voters drop off their votes before polls close in the state. Elsewhere, huge swaths of the Super Tuesday electorate have made their voting decision only recently, ultimately giving Joe Biden a boost.