Thousands of people will take to streets on Sunday morning for the inaugural Brisbane Times City2South charity run presented by Westpac.

A sister event to Sydney's City2Surf and Melbourne's City2Sea, the Brisbane race will host elite runners - as well as joggers, walkers and pram pushers – from all over Australia, while also raising money for more than 430 charities.

The race will begin in Brisbane's Botanic Gardens, end in Musgrave Park and will cross the Brisbane River three times.

The following road closures apply on Sunday:

4am - 9.30am