Rex Ryan already has beaten the Jets once, on national TV, and would love nothing more than to ruin their season on Sunday. Rex has nothing to lose, his opponent has everything to lose. He can rush eight guys at Ryan Fitzpatrick on every snap and run every trick play in his playbook on offense and special teams if he so desires.

But Todd Bowles has some advantages he didn’t have the last time, when Buffalo stormed to a 22-3 lead and held on for a 22-17 win that almost became a colossal Ryan loss. In that game, Ryan had way more knowledge about the Jets than Bowles did about the Bills. Now, Bowles has a better handle on how to handle quarterback Tyrod Taylor and how to cover receiver Sammy Watkins.

The Bills also will be missing several key players: running back LeSean McCoy, tight end Charles Clay and defensive tackle Marcel Dareus. The Jets are as healthy as a team can be in Week 17.

Yes, it would be a “very Jets thing” for them to get to 10-5 and blow the playoffs by losing to their ex-coach. But the feeling here is with the defense they have, and the running game, and Fitzpatrick pitching to Brandon Marshall and Eric Decker, that they get it done and move on to the tournament.

The pick: Jets, -3.

GIANTS (-3¹/₂) over Eagles: When a team fires its coach with one game to go, it signals to the players that this season’s already over. Meanwhile, for the Giants, you figure Odell Beckham Jr. will want to have a huge game to wipe away some of the bitter taste from the Josh Norman imbroglio and his suspension.

Lions (+1) over BEARS: Not much to choose between these two 6-9 teams. Weather will be OK at sunny and 33. Lions have won the last five against the Bears, so going with Detroit on muscle memory.

DOLPHINS (+10) over Patriots: New England would clinch AFC top seed with a win or tie, or a Broncos loss or tie. But with his offensive line in tatters, don’t expect Bill Belichick to expose Tom Brady to many hits here.

BENGALS (-9) over Ravens: Didn’t want to give quite this many with AJ McCarron on a short week after an overtime Monday-night loss. But the Bengals still have bye incentive, and the Ravens could be satisfied after sticking it to the Steelers out of left field.

Saints (+4) over FALCONS: This could be the final game of the Sean Payton-Drew Brees era for the Saints. Don’t be surprised if Payton empties the playbook and tries to relive the glory days one last time.

TEXANS (-6) over Jaguars: Texans are in a win-and-in spot and are still on a hot run — they’re 6-2 in last eight, and have allowed exactly six points in four of the wins, and 10 in another.

Steelers (-10¹/₂) over BROWNS: Cleveland’s another of those teams with nothing to lose. But with Johnny Manziel questionable with concussion symptoms, the more likely scenario is the Steelers lay it on ’em heavy and root for Rex.

Titans (+6) over COLTS: The Colts are looking at starting Josh Freeman, Ryan Lindley or Stephen Morris at quarterback (Lindley of the infamous Cardinals-Jets game in 2012). The Titans still have a decent defense, and the Colts could sag emotionally if they see the Texans ahead on the scoreboard.

CHIEFS (-7) over Raiders: Chiefs have won nine in a row and can take the AFC West with a win and a Denver loss. They’re also 7-2 versus the spread in that span, including a 14-point win at Oakland as three-point favorites on Dec. 6. Raiders will be in spoiler mode, but just can’t mess with K.C. here.

COWBOYS (-4) over Redskins: The Redskins are locked into the No. 4 seed and will play next week. Any player in need of rest or healing will get it. So you have to stay away from them here.

PANTHERS (-10¹/₂) over Buccaneers: Ron Rivera said he won’t rest his starters with the top seed on the line, so we’ll take him at his word. Panthers would much rather play the Cardinals in Charlotte, N.C., where they beat them last year in the first round, than have to face them in Glendale, Ariz., in the title game.

BRONCOS (-9) over Chargers: The spread’s uncomfortably large, but the Broncos are win-and-in, and dusted the Bolts on Dec. 6 in San Diego with Brock Osweiler at quarterback.

Rams (-3¹/₂) over 49ERS: Nine of the 49ers’ 11 losses have been by double digits. Jeff Fisher’s lively Rams are hot after a .500 season, having won their last three.

Seahawks (+6¹/₂) over CARDINALS: A lot to be giving the Seahawks anytime, anywhere. They can still move up one wild-card spot (and play the Redskins) if they win and the Packers beat the Vikings. The Cards’ motivation for the top seed would wane if they see the Panthers up big.

PACKERS (-3¹/₂) over Vikings: The Packers got crushed in Arizona last week while the Vikings had the perfect time to play the Giants. With the NFC North on the line, going all in with Aaron Rodgers.

Best bets: Packers, Dolphins, Rams

Lock of the Week: Packers (Locks 6-9 in 2015)

Last week: 8-8 overall, 2-1 Best Bets