A list of police questions which Madeleine McCann’s mother Kate refused to answer three months after her daughter disappeared has re-emerged in the media as the 10 year anniversary of her disappearance approaches.

In an interview with Fiona Bruce, Madeleine’s father, Gerry McCann, hit out at “fake news” and the hurt that speculation and conspiracy theories have caused to the family.

But the list of 48 questions Mrs McCann refused to answer has made headlines again a decade after the four-year-old vanished from the family’s holiday apartment in Praia da Luz, Portugal.

A transcript of the interview from 7 September 2007 – three months after Madeleine disappeared in June – was included in extensive police files released to the public in 2008.

Ms McCann, a former GP, was told she was a suspect – or “arguido” – by Portuguese police and questioned in detail over an 11-hour period about the night Madeleine went missing.

She was asked about Madeleine’s relationship with her younger siblings, who are twins, her method of parenting and whether she routinely medicated her children.

The Madeleine McCann case Show all 25 1 /25 The Madeleine McCann case The Madeleine McCann case Madeleine McCann One of the last photos of Madeleine before her disappearance EPA The Madeleine McCann case Madeleine McCann Madeleine McCann was three when she was abducted during a family holiday in 2007 The Madeleine McCann case Top worn by a man that detectives investigate with connection to disappearance of Madeleine McCann A computer generated image of the distinctive burgundy long sleeve top worn by a man that detectives investigating the disappearance of Madeleine McCann are looking for The Madeleine McCann case Apartment in Portugal from where Madeleine went missing An aerial view of the Ocean Club apartments and pool where Madeleine McCann went missing Jeff J Mitchell/Getty Images The Madeleine McCann case Kate McCann Kate McCann speaks to the press outside the court house in Lisbon on 12 September 2013 following the first audience of the McCann couple's libel proceedings against former inspector Goncalo Amaral for a book written about the case of their missing daughter The Madeleine McCann case Kate and Gerry McCann Kate McCann and Gerry McCann before the start of the 'Miles for Missing People' charity run in Regent's Park in London, 2011 The Madeleine McCann case Kate and Gerry McCann Kate and Gerry McCann make an appeal at a press conference in the holiday resort of Praia da Luz, Portugal 7 May 2007 The Madeleine McCann case Kate and Gerry McCann The McCann's give an interview with a Spanish television channel at their home in Rothley The Madeleine McCann case Kate and Gerry McCann Madeleine McCann was abducted in Portugal in May 2007 AP The Madeleine McCann case Kate and Gerry McCann Preliminary forensic analysis on samples recovered from the McCanns' hire car raised the possibility of a match with Madeleine's DNA profile, according to the leaked report Getty Images The Madeleine McCann case Kate and Gerry McCann Pope Benedict XVI blesses a photo of four-year-old abducted British girl Madeleine McCann, while meeting her parents Gerry and Kate McCann, after his weekly general audience at the Vatican, 2007 Reuters The Madeleine McCann case Kate and Gerry McCann Gerald McCann and Kate McCann speak to the press on 4 May 2007 at the Ocean club appartement hotel in Praia de Luz in Lagos after Madeline vanished while her parents were out to dinner The Madeleine McCann case Portuguese police search for Madeleine Dozens of Portuguese police aided by dogs search for missing three-year old British girl Madelaine McCann in front of the Ocean club appartment hotel in Praia de Luz in Lagos The Madeleine McCann case Kate and Gerry McCann Gerald McCann and Kate McCann walk holding their two other children outside the Ocean club apartment hotel in Praia de Luz in May 2007 The Madeleine McCann case Madeleine McCann Madeleine McCann pictured at the age of three, left, and as she might have looked aged nine PA/Teri Blythe The Madeleine McCann case Kate and Gerry McCann The parents of missing Madeleine McCann have described as "pure speculation" reports in the Portuguese press suggesting that a chief suspect in the disappearance of their daughter was killed in a tractor accident four years ago. PA The Madeleine McCann case Tribute for missing Madeleine in Rothley, Leicesteshire Three year old Cally prepares to add a yellow ribbon to a floral tribute for missing Madeleine McCann in Rothley in Leicesteshire, 2007 The Madeleine McCann case Support for the missing Madeleine Everton captain Lee Carsley (L) leads his team onto the field, followed Mikel Arteta (C) and Manuel Fernandes (R) wearing Tshirts bearing a message of support for the missing British toddler Madeleine McCann, prior to the English Premiership match between Chelsea and Everton, at Stamford Bridge in London, 2007 The Madeleine McCann case Madeleine McCann A poster appealing for information about Madeleine McCann at a Spanish railway station PA The Madeleine McCann case BBC's Crimewatch reconstruction of Madeleine McCann's disappearance Former porn star Mark Sloan (L) was cast in the BBC's Crimewatch reconstruction of Madeleine McCann's disappearance BBC The Madeleine McCann case Clarence Mitchell holds two artist's impression of the new suspect McCann family spokesman Clarence Mitchell holds two artist's impression of the new suspect on 20 January 2008 in London. The description has come from British woman Gail Cooper, who was staying with her family close to the McCann's apartment in Portugal The Madeleine McCann case Image of a woman sought in the case Clarence Mitchell, the press spokesman for the McCann family, releases a photofit image of a woman sought in the search for missing Madeleine McCann Getty Images The Madeleine McCann case Suspect in disappearance of Madeleine McCann Police released two e-fits of suspect in disappearance of Madeleine McCann Getty Images The Madeleine McCann case Raymond Hewlett Convicted paedophile Raymond Hewlett, who is being sought in connection with the disappearance of Madeleine McCann PA The Madeleine McCann case A picture of a suspect An artist's impression of a suspicious man seen by a witness apparently watching the McCann family's apartment in Praia da Luz, Portugal, the day before Madeleine McCann went missing Channel 4

The questions Ms McCann refused point blank to answer were:

1 On May 3, 2007, around 22:00, when you entered the apartment, what did you see? What did you do? Where did you look? What did you touch?

2 Did you search inside the master bedroom wardrobe?

3 (Shown two photographs of her bedroom wardrobe) Can you describe its contents?

4 Why was the curtain by the sofa near the side window tampered with? Did someone go behind the sofa?

5 How long did your search of the apartment take after you detected Madeleine’s disappearance?

6 Why did you say Madeleine had been abducted?

7 Assuming Madeleine was abducted, why did you leave the twins to go to the ‘Tapas’ and raise the alarm? The supposed abductor could still be in the apartment.

8 Why didn’t you ask the twins then what happened to their sister or why didn’t you ask them later on?

Madeleine McCann(Family handout/PA) The little girl as she looked when she disappeared a decade ago (PA)

9 When you raised the alarm at the ‘Tapas’ what exactly did you say – what were your exact words?

10 What happened after you raised the alarm there?

11 Why did you go and warn your friends instead of shouting from the verandah?

12 Who contacted the authorities?

13 Who took place in the searches?

14 Did anyone outside the group learn of her disappearance in those following minutes?

15 Did any neighbour offer you help?

16 What does “we let her down” mean?

17 Did Jane Tanner tell you that night she’d seen a man with a child?

18 How were the authorities contacted and which police force was alerted?

19 During the searches, with the police there, where did you search for Maddie, how and in what way?

20 Why did the twins not wake up during that search or when they were taken upstairs?

21 Who did you phone after the occurrence?

22 Did you call Sky News?

23 Did you know the danger of calling the media, because it could influence the abductor?

24 Did you ask for a priest?

25 By what means did you divulge Madeleine’s features, by photographs or by any other means?

26 Is it true that during the searches you remained seated on Maddie’s bed without moving?

27 What was your behaviour that night?

28 Did you manage to sleep?

29 Before travelling to Portugal, did you make any comment about a foreboding or a bad feeling?

30 What was Madeleine’s behaviour like?

31 Did Maddie suffer from any illness or take any medication?

32 What was Madeleine’s relationship like with her brother and sister?

33 What was Madeleine’s relationship like with her brother and sister, friends and school mates?

34 As for your professional life, in how many and which hospitals have you worked?

35 What is your medical speciality?

36 Have you ever done shift work in any emergency services or other services?

37 Did you work every day?

38 At a certain point you stopped working. Why?

39 Are the twins difficult to get to sleep? Are they restless and does that cause you uneasiness?

40 Is it true sometimes you despaired at your children’s behaviour and it left you feeling very uneasy?

41 Is it true that in England you even considered handing over Madeleine’s custody to a relative?

42 In England, did you medicate your children? What type of medication?

43 In the case files, you were shown canine forensic testing films. After watching them, did you say you couldn’t explain any more than you already had?

44 When the sniffer dog also marked human blood behind the sofa, did you say you couldn’t explain any more than you already had?

45 When the sniffer dog marked the scent of corpse coming from the vehicle you hired a month after the disappearance, did you say you couldn’t explain any more than you already had?

46 When human blood was marked in the boot of the vehicle, did you say you couldn’t explain any more than you already had?

47 When confronted with the results of Maddie’s DNA, carried out in a British lab, collected from behind the sofa and the boot of the vehicle, did you say you couldn’t explain any more than you already had?

48 Did you have any responsibility or intervention in your daughter’s disappearance?

Ms McCann answered just one question put to her by the police during the interrogation, when she invoked her right to remain silent in protest at being treated as a suspect. She later said that she refused to co-operate because she thought the police treating her as a suspect was distracting them from the work they should have been doing to find Maddie.

Senior detectives in Portugal and the UK have said repeatedly the McCanns are no longer suspects in the case while the couple, from Leicestershire, have always denied they had any involvement in the disappearance of their daughter.

Their Portuguese lawyer has described the idea that the couple were guilty of any wrongdoing as “unfounded and absurd”.

Claiming they had been demonised in ‘industrial doses’ and describing them as “human beings experiencing deep suffering”, he said the far more logical explanation was that she had been snatched.

Scotland Yard chief Mark Rowley confirmed last week that Madeleine’s parents – who had their suspect status removed in July 2008 when the original Portuguese police probe was archived – were no longer seen as possible suspects.

He said: “The parents’ involvement was dealt with at the time by the original investigation by the Portuguese.

“We’re happy that’s completely dealt with and there is no reason whatsoever to re-open that or start rumours that that’s a line of investigation.”

Mr McCann, a cardiologist, said in the interview with Ms Bruce for the BBC: “I think in this era of ‘fake news’ it is extremely topical and I think people just need to think twice before they write and the effects it has.”

Ms McCann said she and her husband stay away from social media and try to shield their twelve-year-old twins as much as possible.

The couple have received years of abuse because of their decision to leave their children sleeping alone in the apartment while they spent the evening in a nearby tapas bar with friends, taking turns to check on the children..

Mr McCann said of the abuse and accusations: “I’m sure it is a very small minority of people who spend their time doing it, but it has totally inhibited what we do. Personally, we don’t use social media, although we have used it in Madeleine’s campaign.

“But for our twins who are growing up in an era where mobile technology is used all the time, we don’t want them not to be able to use it in the same way that their peers do.”

The couple, who are Catholics, said they still believe their daughter is alive because there is no evidence that she is dead.

Artists have produced impressions of how Maddie might look today, approaching her fourteenth birthday.

The McCanns hold up an image of how their daughter might look today, as a young teenager (LEON NEAL/AFP/GettyImages)

Four Metropolitan Police officers still work full-time to try and solve the case, which has attracted criticism from some that the force should not be spending so much money ten years on from the disappearance.

Ms McCann, who revealed she is working in medicine again although not as a GP, said she believes progress is still being made as there have been fresh lines of enquiry in the past five years.