In the broader sense, manxiety is the result of the aspects of life that modern men worry about – ie. their appearance to others, their well-deserved loss of societal entitlement, their long-since-coming workplace emasculation. Man is no longer the cock of the roost, and he's not taking the demotion very well.

The other interpretation is more literal. Manxiety simply denotes the experience of men who suffer from a medical form of anxiety. (By this logic, female sufferers would have womanxiety. It's enough to make you wonder why we can't just all share the same anxiety).