Multiple shots were fired from a dinghy on the Brisbane River at Mr Percival's overnight, little more than two weeks after the Howard Smith Wharves bar was the target of an arson attack.

Police said the shooting occurred about 2am on Monday and the bullets came from a small vessel carrying three or four people.

Shots were fired from Brisbane River at Mr Percival's bar at Howard Smith Wharves in the early hours of Monday. Credit:Toby Crockford

Nobody was injured, it is unclear whether anyone was inside the Boundary Street bar at the time.

Detectives have appealed for witnesses or anyone with information to contact Policelink on 13 14 44 or Crime Stoppers on 1800 333 000.