A 28-year-old man died in a car crash in North York late Saturday night that also left a 50-year-old woman with life-threatening injuries, Toronto police say.

Shortly after 11 p.m., Toronto police responded to a call about a collision on Steeles Avenue West, west of Islington Avenue.

A 28-year-old man was driving a Lexus west on Steeles, made a U-turn, and struck by the drivers of two vehicles headed east, police said.

A 53-year-old Nissan driver struck the passenger side of his car, while a 45-year-old Honda driver struck another part of the vehicle.

The Lexus driver was pronounced dead at the scene.

A 50-year-old female passenger in the Nissan was rushed to hospital with life-threatening injuries.

The Nissan and Honda drivers were rushed to hospital, but police did not detail the extent of their injuries.

Anyone with information is asked to contact police at 416-808-1900 or Crime Stoppers anonymously at 416-222-TIPS (8477).