The Giants were hurt Sunday by crowd noise, which is quite remarkable, considering they played at home, at MetLife Stadium.

“You don’t think having that [at home], but I guess when you’ve only won two games, there’s a lot of Eagles fans and they were loud,’’ Eli Manning said.

It was a surreal setting, with thousands of Eagles fans filling the seats, making this sound like a game at Lincoln Financial Field. When the Giants had the ball, loud chants of “De-fense … de-fense’’ cascaded down to the field.

“It was pretty loud,’’ Sterling Shepard said. “Where are our fans?’’

Shepard then backtracked a bit, saying: “I don’t get into all that stuff. If their fans were louder than us, I didn’t notice it.’’

On the Eagles 6-yard line with 48 seconds remaining, right tackle Bobby Hart was called for a false start penalty, moving the ball back to the 11-yard line. Manning said it was the fault of the noise.

“I don’t blame Bobby,’’ Manning said. “At home, it’s loud. [Center] Brett Jones couldn’t hear me call out the cadence. I don’t blame our fans. That’s the way this season has turned out.”

It was a rough day for safety Darian Thompson. As the personal punt protector, he allowed Kamu Grugier-Hill to cut inside him for a blocked punt.

“It was a looper that came back and I was supposed to get him,’’ Thompson told The Post. “I didn’t see him until too late.’’

Thompson later missed an open-field tackle on tight end Zach Ertz that led to an Eagles field goal.

“I missed the tackle,’’ Thompson said. “Should have got him down. I don’t know what else to tell you.’’

Landon Collins tried, but could not finish what he started. Despite being listed as doubtful to play, Collins was in uniform, active and kept his streak alive, starting his 46th consecutive game. Collins, though, did not make it out of the first half, as he re-injured his sprained ankle early in the second quarter and did not play the remainder of the game.

The Giants also saw fit to activate cornerback Eli Apple, breaking a stretch of four consecutive games with Apple not in uniform and, essentially, a healthy scratch. … Rookie QB Davis Webb was inactive for the 14th consecutive game. … WR Tavarres King dove into the end zone to complete a 57-yard touchdown, but came away with a concussion. … Manning’s 67-yard scoring pass to Shepard in the second quarter was the 50th touchdown pass for Manning in his career against the Eagles., the most by him against any opponent. Manning has 49 TD passes against the Cowboys. … The Giants reached the end zone on their opening drive for the first time all season. Their previous 13 drives to start games resulted in eight punts, one interception, one fumble and three field goals. … Linebacker B.J. Goodson, who cannot stay healthy this season, walked off gingerly in the third quarter.