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Two people suffered life-threatening injuries when a driver hit pedestrians Wednesday afternoon in San Francisco's Mission District, police said.

A Toyota Prius turned north onto Mission Street from 23rd Street and struck the two pedestrians about 4:20 p.m.

The vehicle then went up on a sidewalk and hit a bus and a person getting off the bus. That person was treated at the scene and released, police said.

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Police said Wednesday that based on preliminary information they suspected the driver was impaired, but a police spokesman said in an email Thursday that "at this point we do not believe DUI as being a factor for this ongoing and open investigation."

The driver of the Prius, identified as a 62-year-old San Francisco man, fled in the car with his passenger but later returned to the scene, and both were detained Wednesday, police said.

The driver was booked for running a red light and two counts of not stopping for an accident, police spokesman Officer Robert Rueca said Thursday.