CCTV footage has captured the moment a plane burst into flames after crashing into a therapy centre for autistic children, both of those on board.

Children and teachers were seen fleeing after the aircraft smashed into the warehouse building in Fort Lauderdale, Florida, on Saturday.

The occupants of the building escaped unharmed, but the pilot and his flight school student died in the crash.

CCTV footage from nearby business H & J Electronics International Inc shows the plane skidding across the ground shortly before hitting the building.

It can be seen immediately erupting into flames before adults and children run out of the building to safety.

Posting the footage on its Facebook page, the company said: “Surveillance footage of the plane crash at our warehouse.

“Unfortunately, the two people on the plane didn’t make it.

“We are praying for the family and friends of the two souls on board.”

Children and teachers were forced to flee an autism therapy centre in Fort Lauderdale, Florida, after a plane crashed into a warehouse building on December 1, 2018. The pilot and his passenger were killed in the crash. (H & J Electronics International Inc) (H & J Electronics International Inc)

The pilot of the six-seat Cessna craft has been named as 51-year-old Eladio Marquez.

The father, from New Jersey, reportedly told air traffic control the plane had a fire in the left engine shortly after take-off.

His widow, Belkis Marquez, said he had been flying for 12 years and had been an instructor for 10.

Children and teachers were forced to flee an autism therapy centre in Fort Lauderdale, Florida, after a plane crashed into a warehouse building on December 1, 2018. The pilot and his passenger were killed in the crash. (Fort Lauderdale Fire Rescue)

She told NBC New York that her husband had never previously had accident.

“He was an excellent pilot, and excellent instructor,” she said.

“It's so difficult for me and for my little son. Everyone loved him and he loved everybody.”

Eight adults and five children are believed to have been at the Positive Behaviour Supports Corporation-run centre, housed inside the warehouse building, at the time of the crash but none were harmed.