"As we move through history, their lives and their careers change dramatically," showrunner Michelle Ashford tells THR. "Whereas most shows stay the same, it's one of those where it will look really different every year."

When Showtime's Masters of Sex returns for its second season, the Michael Sheen and Lizzy Caplan drama will follow real-life sex researchers William Masters and Virginia Johnson out of the hospital and into a different part of St. Louis.

The Hollywood Reporter has a first look at the sophomore season of the drama, which kicks off where the freshman run ended, with Masters (Sheen) standing in the pouring rain at the doorstep of his former partner (in more ways than one), Johnson (Caplan).

"There is one thing I can’t live without," an emotional Masters says. "It’s you."

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At a recent Television Academy panel, Sheen likened his character to “a fish out of water” in the coming season, a description confirmed by the exhausted, distraught Masters featured in the clip above.

The first-look video also shows Masters' wife, Libby (Caitlin FitzGerald), who believed she was infertile for most of the first season, holding their crying newborn. She continues to be frustrated with their marriage and now her husband’s current job situation, or lack thereof.

Virginia, meanwhile, seems to be having problems of her own -- especially of the financial sort. She refuses money from Lillian DePaul (Julianne Nicholson), who reminds her that she had no qualms taking money from Masters -- something Virginia likely would have preferred to forget.

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Tensions are high in the coming season, but the clip seems to end on a promising note for Masters and Virginia. "I’m assuming it’s not an accident meeting in a hotel," Virginia says as Masters proceeds to grab their room key from the front desk.

Executive producer Michelle Ashford recently told THR that the series will continue to explore different aspects of Masters and Johnson's real lives.

"As we move through history, their lives and their careers change dramatically," she said. "Whereas most shows stay the same, it’s one of those where it will look really different every year."

Masters of Sex returns July 13 at 10 p.m. on Showtime. Check out the first-look at season two, above.