Two people have died and three others are injured in a multi-car crash near Bendigo.

Up to four cars and a truck are believed to have been involved in the fatal crash at Harcourt North on Friday night.

Two people, who have not been identified, died at the scene of the crash on the Calder Freeway near Fogartys Gap Road.

Three people were taken to hospital with non-life threatening injuries.

Police are yet to determine what caused the accident, which occurred just after 9pm.

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They are calling for any witnesses or people with dashcam footage to contact Crime Stoppers.

The deaths bring the state’s road toll to 72, compared to 77 this time last year.