Such inversions do not include the centromere. The chromosomal structural changes totally depend on the crossing over event occurring in the looped region. The inverted loops do not create any hindrances in chromosomal structure and cellular development if there is no crossing over in the inverted regions in the loops. Also, the homologous chromosomes separate normally during the anaphase I. However, the presence of the crossing over the event in inverted loops leads to duplications and deletions. They arise due to the physical joining of the chromatids. The crossing over leads to the formation of products incapable of including in a normal gamete. These products include a dicentric chromosome and a reciprocal product known as an acentric chromosome. The chromosome lacking a centromere, known as an acentric chromosome consists of deleted and duplicated regions. The cell loses the acentric and dicentric chromosomes. Those chromatids not participating in the crossing over become eligible for getting included in the gametes. One of the products consists of inversions. Most of the chromosomes having inverted regions suppress the crossing over process.