SALEM -- U.S. Sen. Elizabeth Warren, D-Massachusetts, is pressing President Donald Trump to explain his decision to drop the military's largest non-nuclear weapon on a cave and tunnel system in remote eastern Afghanistan.

The Massachusetts Democrat, who has become a leading critic of the Republican president, raised questions about the Trump administration's military strategy following a Thursday night town hall-style meeting in Salem.

"I want to hear more from the generals out in the field about why they thought this was the right bomb and this was the right moment," she said. "As is the case with every part of Trump's foreign policy, we're all trying to understand: what is the strategy? What is our overall purpose here? And so far we're just not hearing it."

Warren added that the United States needs to learn how many civilians were killed by the 22,000-pound GBU-43/B Massive Ordnance Air Blast bomb -- nicknamed the "Mother of All Bombs" -- that Pentagon officials say was dropped from a U.S. aircraft on an Islamic State of Iraq and Syria-Khorasan tunnel complex in Achin district, Nangarhar province.

"One of the things we want to know is, what is the impact on civilians? I think it's powerfully important ... That's the real question about our future safety," she said, "Who is going to be out there fighting us in the future?"

Jeremy Adler, a spokesman for America Rising Squared -- an arm of the Republican super-PAC, America Rising -- however, said the senator's comments "reveal her blind opposition to anything President Trump does, even if it means opposing a strike that took out some 36 ISIS fighters."

"For once, it'd be nice if Elizabeth Warren checked politics at the door and credited this administration for their smart, tactical decision to bring the fight to America's enemies," he said in a statement.

U.S. Sen. Ed Markey, D-Massachusetts, joined Warren in expressing concerns about possible civilian casualties and questioned whether using such a large bomb was appropriate in Afghanistan.

"President Trump said that he was quite proud of the proportionality of the strike in Syria -- that it minimized civilian deaths," he told CBS Boston. "The question I have, is: was there the same commitment to proportionality in using such a lethal weapon. I'm going to be asking the questions about how many civilians were killed, because if it's a large number that could be used as a recruiting tool by ISIS."

Afghanistan officials said Friday that 36 Islamic State group fighters were killed in the blast, according to the Associated Press. No civilian casualties were reported.

The strike was conducted as part of ongoing efforts to defeat ISIS-K, also known as the Khorasan group, in Afghanistan, according to defense officials. It was designed to minimize the risk to U.S. and Afghan forces while maximizing destruction of ISIS-K fighters and facilities.

The pentagon said U.S. forces took every measure to avoid civilian casualties and will continue their efforts until ISIS-K is destroyed in Afghanistan.

Trump called the strike "another very, very successful mission" and touted his administration's approach to the Middle East.