CLEMSON, S.C. — Chris Blewitt made a 48-yard field goal with six seconds left as Pittsburgh stunned No. 3 Clemson 43-42, spoiling a record-setting Saturday for quarterback Deshaun Watson and complicating the Tigers’ path back to the College Football Playoff.

It was the biggest win for the Panthers (5-4, 3-4 Atlantic Coast Conference) since knocking off No. 2 West Virginia 13-9 in 2007.

Watson threw for an ACC record 580 yards and three touchdowns. But his third interception gave Pitt the chance to crawl back from a 42-34 deficit. After Saleem Brightwell’s pick and 70-yard return, James Conner finished the drive with a 20-yard TD run.

The Panther defense, which gave up 630 yards, rose up when it counted and stopped Wayne Gallman short on third and fourth down to take the ball with 58 seconds left. Two passes to Scott Orndoff put Pitt within range and Blewitt nailed the kick to send the Panthers into a frenzy.