Manchester City are facing the prospect of fixture disruption over the delay to open Tottenham ­Hotspur’s new stadium after it emerged that their big Premier League match on Oct 28 may have to be rearranged or postponed.

Although Spurs have an agreement with the Football Association to move the matches against ­Fulham, Liverpool and Cardiff City to Wembley, as well as what should have been their first NFL fixture on Oct 14, the national stadium is ­hosting its own American football game on Oct 28.

After further talks with the ­Premier League, FA and Uefa, it has become increasingly clear that a new date would be preferred to ­either reversing the fixture with City or introducing a third venue into their season.

The hope on all sides is that the stadium might still be ready for Oct 28 but that date is now simply listed as “TBC” and, with Spurs still waiting for safety issues to be resolved, there is no definitive timescale.

Tottenham had planned to begin life in their £800 million ground against Liverpool on Sept 15.

With the NFL now playing matches at Wembley twice over the space of three October weekends, Tottenham may also ask Uefa if their Champions League match on either Oct 23 or 24 can be away. They will also need permission from European football’s governing body to stage games this season in two different venues.