1. Vinck, M., Batista-Brito, R., Knoblich, U. & Cardin, J. A. Arousal and locomotion make distinct contributions to cortical activity patterns and visual encoding. Neuron 86, 740–754 (2015).

2. Niell, C. M. & Stryker, M. P. Modulation of visual responses by behavioral state in mouse visual cortex. Neuron 65, 472–479 (2010).

3. Bennett, C., Arroyo, S. & Hestrin, S. Subthreshold mechanisms underlying state-dependent modulation of visual responses. Neuron 80, 350–357 (2013).

4. Schneider, D. M., Nelson, A. & Mooney, R. A synaptic and circuit basis for corollary discharge in the auditory cortex. Nature 513, 189–194 (2014).

5. Zhou, M. et al. Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex. Nat. Neurosci. 17, 841–850 (2014).

6. Williamson, R. S., Hancock, K. E., Shinn-Cunningham, B. G. & Polley, D. B. Locomotion and task demands differentially modulate thalamic audiovisual processing during active search. Curr. Biol. 25, 1885–1891 (2015).

7. Ayaz, A., Saleem, A. B., Schölvinck, M. L. & Carandini, M. Locomotion controls spatial integration in mouse visual cortex. Curr. Biol. 23, 890–894 (2013).

8. McGinley, M. J. et al. Waking State: Rapid Variations Modulate Neural and Behavioral Responses. Neuron 87, 1143–1161 (2015).

9. Ozden, I., Dombeck, D. A., Hoogland, T. M., Tank, D. W. & Wang, S. S. H. Widespread state-dependent shifts in cerebellar activity in locomoting mice. PLoS One 7, e42650 (2012).

10. Powell, K., Mathy, A., Duguid, I. & Häusser, M. Synaptic representation of locomotion in single cerebellar granule cells. eLife 4, e07290 (2015).

11. Hoogland, T. M., De Gruijl, J. R., Witter, L., Canto, C. B. & De Zeeuw, C. I. Role of Synchronous Activation of Cerebellar Purkinje Cell Ensembles in Multi-joint Movement Control. Curr. Biol. 25, 1157–1165 (2015).

12. Ghosh, K. K. et al. Miniaturized integration of a fluorescence microscope. Nat. Methods 8, 871–878 (2011).

13. Medina, J. F., Nores, W. L., Ohyama, T. & Mauk, M. D. Mechanisms of cerebellar learning suggested by eyelid conditioning. Curr. Opin. Neurobiol. 10, 717–724 (2000).

14. Gormezano, I., Kehoe, E. J. & Marshall, B. S. Twenty years of classical conditioning research with the rabbit. Prog. Psychobiol. Physiol. Psychol. 10, 197–267 (1983).

15. Kim, J. J. & Thompson, R. F. Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning. Trends Neurosci. 20, 177–181 (1997).

16. De Zeeuw, C. I. & Yeo, C. H. Time and tide in cerebellar memory formation. Curr. Opin. Neurobiol. 15, 667–674 (2005).

17. Carey, M. R. Synaptic mechanisms of sensorimotor learning in the cerebellum. Curr. Opin. Neurobiol. 21, 609–615 (2011).

18. McCormick, D. A. & Thompson, R. F. Cerebellum: essential involvement in the classically conditioned eyelid response. Science 223, 296–299 (1984).

19. Steinmetz, J. E. Brain substrates of classical eyeblink conditioning: a highly localized but also distributed system. Behav. Brain Res. 110, 13–24 (2000).

20. Gentet, L. J., Avermann, M., Matyas, F., Staiger, J. F. & Petersen, C. C. H. Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice. Neuron 65, 422–435 (2010).

21. McGinley, M. J., David, S. V. & McCormick, D. A. Cortical membrane potential signature of optimal states for sensory signal detection. Neuron 87, 179–192 (2015).

22. Reimer, J. et al. Pupil fluctuations track fast switching of cortical states during quiet wakefulness. Neuron 84, 355–362 (2014).

23. Reimer, J. et al. Pupil fluctuations track rapid changes in adrenergic and cholinergic activity in cortex. Nat. Commun. 7, 13289 (2016).

24. Joshi, S., Li, Y., Kalwani, R. M. & Gold, J. I. Relationships between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex. Neuron 89, 221–234 (2016).

25. Kloosterman, N. A. et al. Pupil size tracks perceptual content and surprise. Eur. J. Neurosci. 41, 1068–1078 (2015).

26. Steinmetz, J. E., Rosen, D. J., Chapman, P. F., Lavond, D. G. & Thompson, R. F. Classical conditioning of the rabbit eyelid response with a mossy-fiber stimulation CS: I. Pontine nuclei and middle cerebellar peduncle stimulation. Behav. Neurosci. 100, 878–887 (1986).

27. Hull, C. & Regehr, W. G. Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. Neuron 73, 149–158 (2012).

28. Osborne, L. C., Lisberger, S. G. & Bialek, W. A sensory source for motor variation. Nature 437, 412–416 (2005).

29. Gao, Z. et al. Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning. Neuron 89, 645–657 (2016).

30. Ishikawa, T., Shimuta, M. & Häusser, M. Multimodal sensory integration in single cerebellar granule cells in vivo. eLife 4, e12916 (2015).

31. Sawtell, N. B. Multimodal integration in granule cells as a basis for associative plasticity and sensory prediction in a cerebellum-like circuit. Neuron 66, 573–584 (2010).

32. Huang, C.-C. et al. Convergence of pontine and proprioceptive streams onto multimodal cerebellar granule cells. eLife 2, e00400 (2013).

33. Jörntell, H. & Ekerot, C.-F. Properties of somatosensory synaptic integration in cerebellar granule cells in vivo. J. Neurosci. 26, 11786–11797 (2006).

34. Koekkoek, S. K. E., Den Ouden, W. L., Perry, G., Highstein, S. M. & De Zeeuw, C. I. Monitoring kinetic and frequency-domain properties of eyelid responses in mice with magnetic distance measurement technique. J. Neurophysiol. 88, 2124–2133 (2002).

35. Boele, H. J., Koekkoek, S. K. E. & De Zeeuw, C. I. Cerebellar and extracerebellar involvement in mouse eyeblink conditioning: the ACDC model. Front. Cell. Neurosci. 3, 19 (2010).

36. Meijer, J. H. & Robbers, Y. Wheel running in the wild. Proc. Biol. Sci. 281, 20140210 (2014).

37. Aston-Jones, G. & Cohen, J. D. An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu. Rev. Neurosci. 28, 403–450 (2005).

38. Carey, M. R. & Regehr, W. G. Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals. Neuron 62, 112–122 (2009).

39. Dieudonné, S. Serotonergic neuromodulation in the cerebellar cortex: cellular, synaptic, and molecular basis. Neuroscientist 7, 207–219 (2001).

40. Olson, L. & Fuxe, K. On the projections from the locus coeruleus noradrealine neurons: the cerebellar innervation. Brain Res. 28, 165–171 (1971).

41. Bloom, F. E., Hoffer, B. J. & Siggins, G. R. Studies on norepinephrine-containing afferents to Purkinje cells of art cerebellum. I. Localization of the fibers and their synapses. Brain Res. 25, 501–521 (1971).

42. Paukert, M. et al. Norepinephrine controls astroglial responsiveness to local circuit activity. Neuron 82, 1263–1270 (2014).

43. Martins, A. R. O. & Froemke, R. C. Coordinated forms of noradrenergic plasticity in the locus coeruleus and primary auditory cortex. Nat. Neurosci. 18, 1483–1492 (2015).

44. Ciocchi, S., Passecker, J., Malagon-Vina, H., Mikus, N. & Klausberger, T. Brain computation. Selective information routing by ventral hippocampal CA1 projection neurons. Science 348, 560–563 (2015).

45. Jayaprakash, N. et al. Optogenetic Interrogation of Functional Synapse Formation by Corticospinal Tract Axons in the Injured Spinal Cord. J. Neurosci. 36, 5877–5890 (2016).

46. Tye, K. M. et al. Amygdala circuitry mediating reversible and bidirectional control of anxiety. Nature 471, 358–362 (2011).

47. Bengtsson, F. & Jörntell, H. Sensory transmission in cerebellar granule cells relies on similarly coded mossy fiber inputs. Proc. Natl. Acad. Sci. USA 106, 2389–2394 (2009).

48. ten Brinke, M. M. et al. Evolving Models of Pavlovian Conditioning: Cerebellar Cortical Dynamics in Awake Behaving Mice. Cell Rep. 13, 1977–1988 (2015).

49. Chabrol, F. P., Arenz, A., Wiechert, M. T., Margrie, T. W. & DiGregorio, D. A. Synaptic diversity enables temporal coding of coincident multisensory inputs in single neurons. Nat. Neurosci. 18, 718–727 (2015).

50. Edgley, S. A. & Lidierth, M. The discharges of cerebellar Golgi cells during locomotion in the cat. J. Physiol. (Lond.) 392, 315–332 (1987).

51. Arenkiel, B. R. et al. In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron 54, 205–218 (2007).

52. Barski, J. J., Dethleffsen, K. & Meyer, M. Cre recombinase expression in cerebellar Purkinje cells. Genesis 28, 93–98 (2000).

53. Madisen, L. et al. A toolbox of Cre-dependent optogenetic transgenic mice for light-induced activation and silencing. Nat. Neurosci. 15, 793–802 (2012).

54. Fünfschilling, U. & Reichardt, L. F. Cre-mediated recombination in rhombic lip derivatives. Genesis 33, 160–169 (2002).

55. Carey, M. R. et al. Presynaptic CB1 receptors regulate synaptic plasticity at cerebellar parallel fiber synapses. J. Neurophysiol. 105, 958–963 (2011).

56. Heiney, S. A., Kim, J., Augustine, G. J. & Medina, J. F. Precise control of movement kinematics by optogenetic inhibition of Purkinje cell activity. J. Neurosci. 34, 2321–2330 (2014).

57. Mostofi, A., Holtzman, T., Grout, A. S., Yeo, C. H. & Edgley, S. A. Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex. J. Neurosci. 30, 8920–8934 (2010).

58. Van Der Giessen, R. S. et al. Role of olivary electrical coupling in cerebellar motor learning. Neuron 58, 599–612 (2008).

59. Steinmetz, A. B. & Freeman, J. H. Localization of the cerebellar cortical zone mediating acquisition of eyeblink conditioning in rats. Neurobiol. Learn. Mem. 114, 148–154 (2014).

60. Yeo, C. H., Hardiman, M. J. & Glickstein, M. Classical conditioning of the nictitating membrane response of the rabbit. I. Lesions of the cerebellar nuclei. Exp. Brain Res. 60, 87–98 (1985).

61. Ohmae, S. & Medina, J. F. Climbing fibers encode a temporal-difference prediction error during cerebellar learning in mice. Nat. Neurosci. 18, 1798–1803 (2015).

62. Chettih, S. N., McDougle, S. D., Ruffolo, L. I. & Medina, J. F. Adaptive timing of motor output in the mouse: the role of movement oscillations in eyelid conditioning. Front. Integr. Neurosci. 5, 72 (2011).

63. Heiney, S. A., Wohl, M. P., Chettih, S. N., Ruffolo, L. I. & Medina, J. F. Cerebellar-dependent expression of motor learning during eyeblink conditioning in head-fixed mice. J. Neurosci. 34, 14845–14853 (2014).

64. Machado, A. S., Darmohray, D. M., Fayad, J., Marques, H. G. & Carey, M. R. A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice. eLife 4, e07892 (2015).

65. Lee, K. H. et al. Circuit mechanisms underlying motor memory formation in the cerebellum. Neuron 86, 529–540 (2015).

66. Siegle, J. H., Hale, G. J., Newman, J. P. & Voigts, J. Neural ensemble communities: open-source approaches to hardware for large-scale electrophysiology. Curr. Opin. Neurobiol. 32, 53–59 (2015).

67. Lopes, G. et al. Bonsai: an event-based framework for processing and controlling data streams. Front. Neuroinform. 9, 7 (2015).