Vice President Joe Biden will make his 2016 campaign-trail debut Monday in blue-collar Scranton, Pa., where he is expected to draw on his boyhood in northeastern Pennsylvania during a joint appearance with Hillary Clinton.

Mr. Biden and the Democratic presidential nominee are scheduled to appear in the predominantly white city of about 75,000, where both Democrats have family ties. The two initially planned to make a joint appearance last month in the economically struggling region, but the event was postponed after the shooting...