Minicircles for transgene expression



Gene therapy is the process of intentionally altering an organism's DNA in order to induce the expression of new genes and the production of new proteins. This concept holds tremendous therapeutic potential as a potentially curative treatment that can address the root causes of genetic disorders.



Minicircles are a novel vector for gene therapy without many of the downsides associated with traditional techniques. The paper being discussed is a proof-of-concept for the viability of minicircles as a tool for effective, safe transgene expression in mammals.





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