More than 100 handguns have been stolen from a firearms store in Perth's southern suburbs, with police describing the theft as a highly organised heist and saying there could be "disastrous" consequences.

Police said 130 handguns including revolvers and semi-automatics were stolen from Barry and Son Firearms in Beckenham on the night of March 11.

The guns are valued at about $5,000 each on the black market, taking the total value of the stolen firearms to $650,000.

Officers have appealed for help to find the guns — many of which were in plastic cases — and the thieves who took them.

Police have released pictures of some of the stolen handguns in a bid to help find them. ( Supplied: WA Police )

"It is a massive concern that there are 130 handguns out there," Detective Senior Sergeant Darren Hart said.

"The only reason for someone to possess an illicit handgun is a bad reason ... if you want to threaten injury or kill somebody. There is no good reason.

"It's only a matter of time before something disastrous happens."

The thieves were recorded on CCTV arriving at and leaving the gun store on Clapham Street in a dark Holden HSV GTS sedan between 10:20pm and 2:50am, indicating they spent more than four hours at the property.

A CCTV image of the dark-coloured sedan used by the thieves has also been released by police. ( Supplied: WA Police )

The ABC understands the thieves cut through the metal exterior of the building and then a brick wall, removing the bricks one by one to get access to a safe room where the guns were stored.

It is believed there were at least three people involved in the burglary, and police have refused to rule out whether it was an inside job.

"That's one of a number of lines of inquiry we are pursuing as you would expect," Detective Senior Sergeant Hart said.

An alarm system was installed at the shop, however it is understood it was not activated.

Organised crime gangs not ruled out

Detective Senior Sergeant Hart said police were also not ruling out the involvement of organised crime gangs, but said there was no evidence to suggest it at this stage.

Detective Senior Sergeant Darren Hart says he suspects each and every gun will be used for crime. ( ABC News: Laura Gartry )

"You couldn't rule out that they would make their way back to organised criminals if they aren't already, or perhaps it is gang related. Who knows," he said.

"I would strongly suspect that each and every one is going to be used for some form of crime."

No ammunition was stolen during the burglary, but police said it could be obtained illegally relatively easily.

"The guns are capable of firing straight out of the box if you can find the ammunition for them," Detective Senior Sergeant Hart said.

Police have appealed for anyone who may have seen the vehicle, who knows someone in possession of a large number of handguns or has any information about the heist to contact them immediately.