President Trump speaks during the daily briefing on the novel coronavirus at the White House on April 22. Mandel Ngan/AFP/Getty Images

“It’s just too soon.” President Donald Trump said he “strongly” disagreed with the Georgia governor’s decision to allow beauty salons, barbershops and other businesses to reopen this week, contradicting both his own impatient insistence that states restart the economy — and a source who said he had supported the move. Some mayors in Georgia are also pushing back against the governor.

A coronavirus model routinely cited by the White House warns that no state should be opening before May 1, and that Georgia shouldn't reopen until June 19.

But other state and city officials disagree. “I’d love everything open,” Las Vegas Mayor Carolyn Goodman told CNN’s Anderson Cooper, appearing to offer up the city as a “control group” without social distancing measures to compare against other places with strict guidelines. Pressed on how she would prevent the spread of the virus in casinos and hotels, she suggested it wasn’t the government’s job to ensure safety in those workplaces.

As the debate over when and how to ease restrictions rattles on, the Trump administration and the nation’s top scientists seem to be increasingly at odds. A virus vaccine chief says he was ousted after resisting efforts to push unproven drugs promoted by the President. It’s an alarming new sign that, under Trump, scientists can speak — but only if they stay in line, Stephen Collinson writes.

Here are today's other developments...

“Unprecedented” post-war recession underway: Ratings agency Fitch says the world is headed for a recession of “unprecedented depth in the post-war period” with global gross domestic product forecasted to fall by 3.9% in 2020. “This is twice as large as the decline anticipated in our early April GEO [global economic outlook] update and would be twice as severe as the 2009 recession,” Fitch’s chief economist said.

"We’re just not making progress on testing": To end the coronavirus pandemic, the US is either going to have to continue with extreme social distancing measures or do it with "ubiquitous" testing, according to Dr. Anish Jha, the director of the Harvard Global Health Initiative.

And the US isn't making enough progress on the latter, Jha said: "We have estimated we need at least three times as much testing as we have right now."

New revelations about ventilators, strokes: About a quarter of coronavirus patients who needed ventilators to help them breathe died within the first few weeks of treatment, a study of New York's largest health system showed.

And another revelation: coronavirus appears to be causing sudden strokes in adults in their 30s and 40s, who are not otherwise terribly ill, doctors say.

Latin America lockdowns leave poor in the lurch: Demonstrators took to the streets of Colombia’s capital Bogota yesterday, protesting over what they say is a lack of support from the government during the country's lockdown.

Elsewhere in Latin America, outbreaks are reaching serious phases of spread, but with little in the way of critical health care. Cases in Mexico have passed 10,000 after the largest single day spike of 1,043 was reported; 970 have died.

And facing a mounting death toll, excavators are digging mass graves in Manaus, Brazil, according to CNN affiliate CNN Brasil.

"A second wave is coming" Many Wuhan residents believe there could be a second wave in the epicenter of the outbreak, now that the city is returning to normal life.

Hector Retamal, a photojournalist with Agence France-Presse, who covered the lockdown and is documenting the city’s reopening, says the anxiety is palpable: “I still see the fear in people who timidly return to the streets.”

A version of this story first appeared in CNN's daily Coronavirus: Fact Vs. Fiction newsletter. Sign up here.

Update: After a story about a study on the rate of deaths among Covid-19 patients on ventilators in a New York health system published, the study’s authors updated the data in the report. This post has been updated to reflect the corrected data.