But Ms. Diller’s hard-hitting approach to one-liners — inspired by Bob Hope, who became an early champion — was something new for a woman. Her success proved that female comedians could be as aggressive or unconventional as their male counterparts, and leave an audience just as devastated. She cleared the way for the likes of Joan Rivers, Roseanne Barr, Whoopi Goldberg, Ellen DeGeneres and numerous others.

Although Ms. Diller used writers to help create her act, she estimated that she wrote 75 percent of the jokes herself. Her approach to humor was methodical. “My material was geared towards everyone of all ages and from different backgrounds, and I wanted to hit them right in the middle,” she explained in her autobiography, “Like a Lampshade in a Whorehouse: My Life in Comedy” (2005), written with Richard Buskin. “I didn’t want giggles — I could get those with my looks — I wanted boffs, and I wanted people to get the joke at the same moment and laugh together. That way I could leave everything to my timing.”

She liked jokes that piled on the laughs in rapid succession. A favorite of hers was this one: “I realized on our first wedding anniversary that our marriage was in trouble. Fang gave me luggage. It was packed. My mother damn near suffocated!”

Phyllis Ada Driver was born on July 17, 1917, in Lima, Ohio, the daughter of Perry Driver, an insurance executive, and the former Frances Ada Romshe. As a child she became interested in classical music, writing and theater.

After briefly attending the Sherwood Conservatory of Music in Chicago, she entered Bluffton College in Bluffton, Ohio, near Lima, with thoughts of becoming a music teacher. She met Sherwood Anderson Diller in her senior year in college, and they were married in 1939.

She never taught music. The Dillers moved to California, where he was an inspector at a Navy air station and later held various other jobs — none, by Ms. Diller’s account, for very long. They struggled financially, even with Ms. Diller working. She wrote a shopping column for a newspaper in San Leandro and advertising copy for a department store in Oakland, then moved on to writing and promotion jobs at radio stations in Oakland and San Francisco.