Received: from usculsndmail13v.am.sony.com (146.215.230.104) by ussdixhub21.spe.sony.com (43.130.141.76) with Microsoft SMTP Server id 8.3.297.1; Wed, 5 Mar 2014 14:47:20 -0800 Received: from usculsndmail01v.am.sony.com ([160.33.194.228]) by usculsndmail13v.am.sony.com (Sentrion-MTA-4.2.2/Sentrion-MTA-4.2.2) with ESMTP id s25MlIOV003850 for <michael_lynton@spe.sony.com>; Wed, 5 Mar 2014 22:47:18 GMT Received: from mail108-tx2-R.bigfish.com (mail-tx2.bigfish.com [65.55.88.113]) by usculsndmail01v.am.sony.com (Sentrion-MTA-4.2.2/Sentrion-MTA-4.2.2) with ESMTP id s25MmSGO013621 (version=TLSv1/SSLv3 cipher=RC4-SHA bits=128 verify=FAIL) for <michael_lynton@spe.sony.com>; Wed, 5 Mar 2014 22:48:28 GMT Received: from mail108-tx2 (localhost [127.0.0.1]) by mail108-tx2-R.bigfish.com (Postfix) with ESMTP id 89B5F4E01B4 for <michael_lynton@spe.sony.com>; Wed, 5 Mar 2014 22:47:17 +0000 (UTC) X-Forefront-Antispam-Report: CIP:64.12.143.80;KIP:(null);UIP:(null);IPV:NLI;H:omr-m06.mx.aol.com;RD:omr-m06.mx.aol.com;EFVD:NLI X-SpamScore: 10 X-BigFish: vps10(z569dhzc89bh1a09Jc857hdb82hzz1f42h208ch1ee6h1de0h1ce5h1fdah201ch2073h2146h1202h1e76h2189h1d1ah1d2ah21bch1696nzz8275bh1de097h18602ehz2fh5fh2a8h839hd25h1060h1288h12a5h12bdh137ah139eh13eah1441h1504h1537h162dh1631h1758h1898h18e1h1946h19b5h19ceh1b0ah1bceh224fh1c07h1d0ch1d2eh1d3fh1dc1h1dfeh1dffh1e1dh1e23h1fe8h1ff5h20f0h2218h2216h226dh22d0h24afh2327h2336h2438h2461h2487h24d7h2516h2545h255eh25f6h2605h1c48i8d1m1155h) X-FFO-Routing-Override: spe.sony.com%sentrionwest-1422.customer.frontbridge.com; Received-SPF: pass (mail108-tx2: domain of aol.com designates 64.12.143.80 as permitted sender) client-ip=64.12.143.80; envelope-from=ayoubre@aol.com; helo=omr-m06.mx.aol.com ;6.mx.aol.com ; Received: from mail108-tx2 (localhost.localdomain [127.0.0.1]) by mail108-tx2 (MessageSwitch) id 1394059635937451_565; Wed, 5 Mar 2014 22:47:15 +0000 (UTC) Received: from TX2EHSMHS013.bigfish.com (unknown [10.9.14.240]) by mail108-tx2.bigfish.com (Postfix) with ESMTP id D0A494006D for <michael_lynton@spe.sony.com>; Wed, 5 Mar 2014 22:47:15 +0000 (UTC) Received: from omr-m06.mx.aol.com (64.12.143.80) by TX2EHSMHS013.bigfish.com (10.9.99.113) with Microsoft SMTP Server (TLS) id 14.16.227.3; Wed, 5 Mar 2014 22:47:15 +0000 Received: from mtaomg-mbc01.mx.aol.com (mtaomg-mbc01.mx.aol.com [172.26.221.143]) by omr-m06.mx.aol.com (Outbound Mail Relay) with ESMTP id A5FB970031603 for <michael_lynton@spe.sony.com>; Wed, 5 Mar 2014 17:47:14 -0500 (EST) Received: from core-dtb001a.r1000.mail.aol.com (core-dtb001.r1000.mail.aol.com [172.29.162.193]) by mtaomg-mbc01.mx.aol.com (OMAG/Core Interface) with ESMTP id 4A05438000096; Wed, 5 Mar 2014 17:47:14 -0500 (EST) To: <michael_lynton@spe.sony.com> Subject: Chemical Marker X-MB-Message-Source: WebUI Received: from 71.129.49.109 by webmail-m204.sysops.aol.com (64.12.75.244) with HTTP (WebMailUI); Wed, 05 Mar 2014 17:47:13 -0500 From: =?utf-8?Q?Alondra_Oubr=C3=A9?= <ayoubre@aol.com> X-MB-Message-Type: User X-Mailer: AOL Webmail 38430-BASIC CC: <ayoubre@aol.com> Message-ID: <8D106DBFC7902D5-22D4-6054@webmail-m204.sysops.aol.com> X-Originating-IP: [71.129.49.109] Date: Wed, 5 Mar 2014 17:47:14 -0500 x-aol-global-disposition: G DKIM-Signature: v=1; a=rsa-sha256; c=relaxed/relaxed; d=mx.aol.com; s=20121107; t=1394059634; bh=YmzQo8svdrmvw7c6D395GHi3IeuJDNAqUTDMb2x0m2c=; h=From:To:Subject:Message-Id:Date:MIME-Version:Content-Type; b=U7igWoa9tYj8j2xAED02sVKIp3utS4WOG6VvQ6deV6YFjKCK/yCXAWq19Ov009rub mgNFXqHNoJ3Fp70dQZFFEMugBKUWdfmQQoO63MNHJNj33dAZbh+V+ISUEUjVqJ+ePY 3BdA0py0i5/OG4cEXb9ZI/oJAVWwYtWIR8u6Sw0s= x-aol-sid: 3039ac1add8f5317a972429a Return-Path: ayoubre@aol.com Status: RO MIME-Version: 1.0 Content-Type: multipart/mixed; boundary="--boundary-LibPST-iamunique-1646860881_-_-" ----boundary-LibPST-iamunique-1646860881_-_- Content-Type: text/html; charset="utf-8" <!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 3.2//EN"> <HTML> <HEAD> <META HTTP-EQUIV="Content-Type" CONTENT="text/html; charset=utf-8"> <META NAME="Generator" CONTENT="MS Exchange Server version 08.03.0330.000"> <TITLE>Chemical Marker </TITLE> </HEAD> <BODY> <!-- Converted from text/rtf format --> <P><SPAN LANG="en-us"><FONT COLOR="#000000" SIZE=2 FACE="Arial">Michael,<BR> <BR> Your marker tracking system idea is ingenious. During my career I have worked with several startups or early stage companies (a couple of them relatively successful), and I really like the challenge and energy of being a part of them.<BR> <BR> Below are several ideas I've jotted down related to your project. You're probably already aware of them but I thought I'd mention them anyway.</FONT><BR> <BR> <BR> <FONT FACE="Arial">I. Chemical Marker<BR> <BR> Single chemical entity/marker compounds added to all legally dispensed marijuana (safe, intentional "adulterant").<BR> <BR> Certain bioavailability enhancer compounds (e.g., as used in botanical medicines) might be good biomarker candidates.<BR> <BR> Such biomarker(s) conceivably could be used with a future high-performing version of the Draeger DrugTest 5000, similar saliva analyzer device, or possibly next-gen breath test, urine tests (less preferable) with all tests designed to detect the added biomarkers as well as key cannabis active constituents.<BR> <BR> <BR> <BR> II. Chemical or DNA Fingerprinting<BR> <BR> Cultivate specialized cannabis strain with unique chemical (e.g., terpene) marker(s) (to minimize alteration of parent cannabis strain).<BR> <BR> Develop unique genetic (DNA) marker(s) for cannabis ID strain (this may be difficult to achieve and not cost-effective).<BR> <BR> Fingerprint would be patented and/or proprietary, if possible, depending upon current natural product patent regulations.<BR> <BR> Small quantities of the "identifier modified strain" could be added to all commercially legal marijuana.<BR> <BR> Basic saliva, breath, urine, and blood tests would have to be modified to detect a strain-specific marker (whether a primary active THC-related compound or secondary compound such as a terpene). <BR> <BR> Not very practical; cost may be prohibitive (extensive R&D to create a customized strain that is unavailable to black market, high legal fees for permits, etc.)<BR> <BR> <BR> <BR> III. Cannabis Nanotechnology Delivery System<BR> <BR> Develop patented and/or proprietary nanotechnology delivery system (i.e., for potentiated delivery of THC, CBD (possibly CBN, THCCOOH) to add to all legal sources of marijuana.<BR> <BR> Nanoparticles would produce user enhancement benefits (NOT necessarily a good idea!) while also providing a unique chemical fingerprint for identifying the legal botanical sources. Nanoparticles could be designed for detection in next-gen cannabis breathalyzers or body fluid analyzers.<BR> <BR> Considerable R&D costs may be involved with no guarantee of outcome.<BR> <BR> If successful product is developed, however, it could have multiple applications for other herbal medicine products and beyond.<BR> <BR> <BR> <BR> IV. Related Project: Digital State-wide Marijuana Tracking System Software<BR> <BR> Colorado still needs a seamless interface between the older medical marijuana industry based point of sale systems and the State's newly mandated Marijuana Inventory Tracking Solutions that utilizes RFID tags.<BR> <BR> Washington State may be interesting in implementing a similar system.<BR> <BR> <BR> <BR> </FONT><FONT COLOR="#000000" SIZE=2 FACE="Arial">Please let me know if you need assistance with literature research, subject matter expert interviews, or writing a proposal, business plan, or evidence-based proof of concept white paper. Many thanks.<BR> <BR> Best regards,<BR> <BR> Alondra<BR> </FONT><BR> <BR> </SPAN> <BR><SPAN LANG="en-us"><FONT FACE="Arial">Alondra Oubré, Ph.D.<BR> Consultant Medical & Science Writer<BR> www.alondraoubre.com<BR> 818-620-7273</FONT></SPAN> </P> </BODY> </HTML> ----boundary-LibPST-iamunique-1646860881_-_---