After losing her job and learning that her husband has been unfaithful, a woman hits the road with her profane, hard-drinking grandmother.

Melissa McCarthy / Susan Sarandon / Kathy Bates / Allison Janney / Dan Aykroyd / Mark Duplass / Gary Cole / Nat Faxon / Toni Collette / Sandra Oh / Ben Falcone / Sarah Baker / Rich Williams / Steve Little / Dakota Lee

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