WASHINGTON — The House gave overwhelming final approval on Tuesday to a package of measures intended to ease access to capital and investments for entrepreneurs, sending the bipartisan legislation to President Obama, who has said he will sign it.

The 380-to-41 House vote added a final exclamation point for the JOBS Act, which passed the House overwhelmingly early this month and easily passed the Senate last Thursday. Because the Senate amended the House version to add some investor protections, the House had to take it back up for a vote before sending it to the White House.

“The bipartisan JOBS Act represents an increasingly rare legislative victory in Washington where both sides seized the opportunity to work together, improved the bill and passed it with strong bipartisan support,” said Representative Eric Cantor, Republican of Virginia, the House majority leader and the primary architect of the package.

The JOBS Act started as a cluster of minor bills that had bipartisan support and little opposition. Many of them originated at the White House out of the recommendations of Mr. Obama’s jobs council, a group of business and labor leaders whose final report made few waves.