Acosta-Maldonado B, Sánchez-Ramírez B, Reza-López S, Levario-Carrillo M (2009) Effects of exposure to pesticides during pregnancy on placental maturity and weight of newborns: a cross-sectional pilot study in women from the Chihuahua State, Mexico. Hum Exp Toxicol 28:451–459

Adeeko A et al (2003) Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome. Toxicol Sci 74:407–415

Altamirano GA, Muñoz-de-Toro M, Luque EH, Gómez AL, Delconte MB, Kass L (2015) Milk lipid composition is modified by perinatal exposure to bisphenol A. Mol Cell Endocrinol 411:258–267

Anadón A et al (2009) Toxicokinetics of glyphosate and its metabolite aminomethyl phosphonic acid in rats. Toxicol Lett 190:91–95

Anway MD, Cupp A, Uzumcu M, Skinner MK (2005) Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308:1466–1469

Anway MD, Leathers C, Skinner MK (2006) Endocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease. Endocrinology 147:5515–5523

Arregui MC, Lenardon A, Sanchez D, Maitre MI, Scotta R, Enrique S (2004) Monitoring glyphosate residues in transgenic glyphosate-resistant soybean. Pest Manag Sci 60:163–166

Avila-Vazquez M, Maturano E, Etchegoyen A, Difilippo F, Maclean B (2017) Association between cancer and environmental exposure to glyphosate. Int J Clin Med 8:73–85

Bai SH, Ogbourne SM (2016) Glyphosate: environmental contamination, toxicity and potential risks to human health via food contamination. Environ Sci Pollut Res 23:18988–19001

Barker DJ (1995) Fetal origins of coronary heart disease. BMJ 311:171–174

Barker DJ, Hales CN, Fall C, Osmond C, Phipps K, Clark P (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36:62–67

Barron S, Thomson A (1983) Obstetrical epidemiology. Academic Press, London

Battaglin W, Kolpin D, Scribner E, Kuivila K, Sandstrom M (2005) Glyphosate, other herbicides, and transformation products in Midwestern streams. J Am Water Resour Assoc 41:323–332

Battaglin W, Meyer M, Kuivila K, Dietze J (2014) Glyphosate and its degradation product AMPA occur frequently and widely in US soils, surface water, groundwater, and precipitation. J Am Water Resour Assoc 50:275–290

Benachour N, Séralini GE (2009) Glyphosate formulations induce apoptosis and necrosis in human umbilical, embryonic, and placental cells. Chem Res Toxicol 22:97–105

Benbrook CM (2016) Trends in glyphosate herbicide use in the United States and globally. Environ Sci Eur 28:3

Bernal J, Bernal JL, Martin MT, Nozal MJ, Anadón A, Martínez-Larrañaga MR, Martínez MA (2010) Development and validation of a liquid chromatography–fluorescence–mass spectrometry method to measure glyphosate and aminomethylphosphonic acid in rat plasma. J Chromatogr B 878:3290–3296

Beuret CJ, Zirulnik F, Giménez MS (2005) Effect of the herbicide glyphosate on liver lipoperoxidation in pregnant rats and their fetuses. Reprod Toxicol 19:501–504

Bromilow RH, Chamberlain K (2000) The herbicide glyphosate and related molecules: physicochemical and structural factors determining their mobility in phloem. Pest Manag Sci 56:368–373

Bruner-Tran KL, Osteen KG (2011) Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Reprod Toxicol 31:344–350

Burdorf A, Brand T, Jaddoe V, Hofman A, Mackenbach J, Steegers E (2011) The effects of work-related maternal risk factors on time to pregnancy, preterm birth and birth weight: the Generation R study. Occup Environ Med 68:197

Burkhardt T, Schäffer L, Schneider C, Zimmermann R, Kurmanavicius J (2006) Reference values for the weight of freshly delivered term placentas and for placental weight–birth weight ratios. Eur J Obstet Gynecol Reprod Biol 128:248–252

Chang FC, Simcik MF, Capel PD (2011) Occurrence and fate of the herbicide glyphosate and its degradate aminomethylphosphonic acid in the atmosphere. Environ Toxicol Chem 30:548–555

Chevrier C, Warembourg C, Gaudreau E, Monfort C, Le Blanc A, Guldner L, Cordier S (2013) Organochlorine pesticides, polychlorinated biphenyls, seafood consumption, and time-to-pregnancy. Epidemiology 24:251–260

Chiu Y et al (2015) Fruit and vegetable intake and their pesticide residues in relation to semen quality among men from a fertility clinic. Hum Reprod 30:1342–1351

Cuhra M, Bøhn T, Cuhra P (2016) Glyphosate: too much of a good thing? Front Environ Sci 4:28

Dallegrave E, Mantese FD, Oliveira RT, Andrade AJ, Dalsenter PR, Langeloh A (2007) Pre-and postnatal toxicity of the commercial glyphosate formulation in Wistar rats. Arch Toxicol 81:665–673

Defarge N, Takács E, Lozano VL, Mesnage R, Spiroux de Vendômois J, Séralini GE, Székács A (2016) Co-formulants in glyphosate-based herbicides disrupt aromatase activity in human cells below toxic levels. Int J Environ Res Public Health 13:264. https://doi.org/10.3390/ijerph13030264

Den Hond E et al (2015) Human exposure to endocrine disrupting chemicals and fertility: a case–control study in male subfertility patients. Environ Int 84:154–160

Drake AJ, Liu L, Kerrigan D, Meehan RR, Seckl JR (2011) Multigenerational programming in the glucocorticoid programmed rat is associated with generation-specific and parent of origin effects. Epigenetics 6:1334–1343

EPA (2017) Glyphosate. Dietary exposure analysis in support of registration review. https://www.regulations.gov/document?D=EPA-HQ-OPP-2009-0361-0071 Accessed 12 Apr 2018

Fischer R, Byerlee D, Edmeades G (2014) Crop yields and global food security: will yield increase continue to feed the world? Australian Centre for International Agricultural Research, Canberra

Fowden A, Forhead A, Coan P, Burton G (2008) The placenta and intrauterine programming. J Neuroendocrinol 20:439–450

Gallegos CE, Bartos M, Bras C, Gumilar F, Antonelli MC, Minetti A (2016) Exposure to a glyphosate-based herbicide during pregnancy and lactation induces neurobehavioral alterations in rat offspring. Neurotoxicology 53:20–28

García J, Ventura MI, Requena M, Hernández AF, Parrón T, Alarcón R (2017) Association of reproductive disorders and male congenital anomalies with environmental exposure to endocrine active pesticides. Reprod Toxicol 71:95–100

Guerrero Schimpf M, Milesi MM, Ingaramo PI, Luque EH, Varayoud J (2017) Neonatal exposure to a glyphosate based herbicide alters the development of the rat uterus. Toxicology 376:2–14

Hales CN, Barker DJ, Clark PM, Cox LJ, Fall C, Osmond C, Winter P (1991) Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 303:1019–1022

Ibáñez L, Potau N, Francois I, de Zegher F (1998) Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth. J Clin Endocrinol Metab 83:3558–3562

Ingaramo PI, Varayoud J, Milesi MM, Guerrero Schimpf M, Muñoz-de-Toro M, Luque EH (2016) Effects of neonatal exposure to a glyphosate-based herbicide on female rat reproduction. Reproduction 152:403–415

Ingaramo PI, Varayoud J, Milesi MM, Guerrero Schimpf M, Alarcón R, Muñoz-de-Toro M, Luque EH (2017) Neonatal exposure to a glyphosate-based herbicide alters uterine decidualization in rats. Reprod Toxicol 73:87–95

Kass L, Altamirano GA, Bosquiazzo VL, Luque EH, Muñoz-de-Toro M (2012) Perinatal exposure to xenoestrogens impairs mammary gland differentiation and modifies milk composition in Wistar rats. Reprod Toxicol 33:390–400

Kongtip P et al (2017) Glyphosate and paraquat in maternal and fetal serums in thai women. J Agromed 22:282–289

Kramer MS (1987) Determinants of low birth weight: methodological assessment and meta-analysis. Bull World Health Organ 65:663

Krüger M, Schledorn P, Schrödl W, Hoppe H-W, Lutz W, Shehata AA (2014a) Detection of glyphosate residues in animals and humans. J Environ Anal Toxicol 4:210. https://doi.org/10.4172/2161-0525.1000210

Krüger M, Schrödl W, Pedersen I, Shehata AA (2014b) Detection of glyphosate in malformed piglets. J Environ Anal Toxicol 4:230. https://doi.org/10.4172/2161-0525.1000230

Londero AP, Bertozzi S, Visentin S, Fruscalzo A, Driul L, Marchesoni D (2013) High placental index and poor pregnancy outcomes: a retrospective study of 18,386 pregnancies. Gynecol Endocrinol 29:666–669

MacDonald MG, Seshia MM, Mullett MD (2005) Avery’s neonatology pathophysiology and management of the newborn. Lippincott Williams and Wilkins, Philadelphia

Macdonald E, Natale R, Regnault T, Koval J, Campbell M (2014) Obstetric conditions and the placental weight ratio. Placenta 35:582–586

Macklon N (2017) Recurrent implantation failure is a pathology with a specific transcriptomic signature. Fertil Steril 108:9–14

Manikkam M, Tracey R, Guerrero-Bosagna C, Skinner MK (2012a) Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations. PLoS One 7(9):e46249

Manikkam M, Tracey R, Guerrero-Bosagna C, Skinner MK (2012b) Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations. Reprod Toxicol 34:708–719

Mañas F, Peralta L, Raviolo J, Ovando HG, Weyers A, Ugnia L, Cid MG, Larripa I, Gorla N (2009) Genotoxicity of AMPA, the environmental metabolite of glyphosate, assessed by the Comet assay and cytogenetic tests. Ecotoxicol Environ Safety 72(3):834–837

Mendez MJ, Aimar SB, Aparicio VC, Haberkon NBR, Buschiazzo DE, De Gerónimo E, Costa JL (2017) Glyphosate and aminomethylphosphonic acid (AMPA) contents in the respirable dust emitted by an agricultural soil of the central semiarid region of Argentina. Aeol Res 29:23–29

Mesnage R, Bernay B, Séralini GE (2013) Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity. Toxicology 313:122–128

Mesnage R et al (2017) Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents. Food Chem Toxicol 108:30–42

Milesi MM, Alarcón R, Ramos JG, Muñoz-de-Toro M, Luque EH, Varayoud J (2015) Neonatal exposure to low doses of endosulfan induces implantation failure and disrupts uterine functional differentiation at the pre-implantation period in rats. Mol Cell Endocrinol 401:248–259

Montes G, Luque E (1988) Effects of ovarian steroids on vaginal smears in the rat. Acta Anat 133:192–199

Mostafalou S, Abdollahi M (2017) Pesticides: an update of human exposure and toxicity. Arch Toxicol 91:549–599

Myers JP et al (2016) Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement. Environ Health 15:19. https://doi.org/10.1186/s12940-016-0117-0

Niemann L, Sieke C, Pfeil R, Solecki R (2015) A critical review of glyphosate findings in human urine samples and comparison with the exposure of operators and consumers. Journal für Verbraucherschutz Lebensmittelsicherheit 10:3–12

Nilsson EE, Anway MD, Stanfield J, Skinner MK (2008) Transgenerational epigenetic effects of the endocrine disruptor vinclozolin on pregnancies and female adult onset disease. Reproduction 135:713–721

Oulkar DP, Hingmire S, Goon A, Jadhav M, Ugare B, Thekkumpurath AS, Banerjee K (2017) Optimization and validation of a residue analysis method for glyphosate, glufosinate, and their metabolites in plant matrixes by liquid chromatography with tandem mass spectrometry. J Assoc Off Anal Chem Int 100:631–639

Paganelli A, Gnazzo V, Acosta H, López SL, Carrasco AE (2010) Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling. Chem Res Toxicol 23:1586–1595

Parvez S et al (2018) Glyphosate exposure in pregnancy and shortened gestational length: a prospective Indiana birth cohort study. Environ Health 17:23. https://doi.org/10.1186/s12940-018-0367-0

Perego MC, Caloni F, Cortinovis C, Schutz LF, Albonico M, Tsuzukibashi D, Spicer LJ (2017) Influence of a roundup formulation on glyphosate effects on steroidogenesis and proliferation of bovine granulosa cells in vitro. Chemosphere 188:274–279

Perobelli JE, Alves TR, de Toledo FC, Fernandez CDB, Anselmo-Franci JA, Klinefelter GR, Kempinas WDG (2012) Impairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepuberty. Reprod Toxicol 33:308–315

Peruzzo PJ, Porta AA, Ronco AE (2008) Levels of glyphosate in surface waters, sediments and soils associated with direct sowing soybean cultivation in north pampasic region of Argentina. Environ Pollut 156:61–66

Primost JE, Marino DJ, Aparicio VC, Costa JL, Carriquiriborde P (2017) Glyphosate and AMPA,“pseudo-persistent” pollutants under real-world agricultural management practices in the Mesopotamic Pampas agroecosystem, Argentina. Environ Pollut 229:771–779

Quintana MM, Vera B, Magnarelli G, Guiñazú N, Rovedatti MG (2017) Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application. Environ Sci Pollut Res 24:20736–20746

Rappazzo KM, Warren JL, Meyer RE, Herring AH, Sanders AP, Brownstein NC, Luben TJ (2016) Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort. Birth Defects Res Part A Clin Mol Teratol 106:240–249

Razi S, Rezaeian M, Dehkordi FG, Manshoori A, Goujani R, Vazirinejad R (2016) Exposure to pistachio pesticides and stillbirth: a case–control study. Epidemiol Health 38:e2016016. https://doi.org/10.4178/epih.e2016016

Richard S, Moslemi S, Sipahutar H, Benachour N, Seralini GE (2005) Differential effects of glyphosate and roundup on human placental cells and aromatase. Environ Health Perspect 113:716–720

Romano MA et al (2012) Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression. Arch Toxicol 86:663–673

Ronco A, Marino D, Abelando M, Almada P, Apartin C (2016) Water quality of the main tributaries of the Paraná Basin: glyphosate and AMPA in surface water and bottom sediments. Environ Monit Assess 188:1–13

Roustan A, Aye M, De Meo M, Di Giorgio C (2014) Genotoxicity of mixtures of glyphosate and atrazine and their environmental transformation products before and after photoactivation. Chemosphere 108:93–100

Roy NM, Carneiro B, Ochs J (2016) Glyphosate induces neurotoxicity in zebrafish. Environ Toxicol Pharmacol 42:45–54

Saenger P, Czernichow P, Hughes I, Reiter EO (2007) Small for gestational age: short stature and beyond. Endocr Rev 28:219–251

SANTE (2015) Guidance document on analytical quality control and method validation procedures for pesticides residues analysis in food and feed. European commission, SANTE/11945/2015. http://www.eurl-pesticides.eu Accessed 22 Dec 2017

Sasal MC et al (2015) Glyphosate loss by runoff and its relationship with phosphorus fertilization. J Agric Food Chem 63:4444–4448

Sathyanarayana S, Basso O, Karr CJ, Lozano P, Alavanja M, Sandler DP, Hoppin JA (2010) Maternal pesticide use and birth weight in the agricultural health study. J Agromed 15:127–136

Skinner MK, Manikkam M, Guerrero-Bosagna C (2011) Epigenetic transgenerational actions of endocrine disruptors. Reprod Toxicol 31:337–343

Skinner MK, Haque CG-BM., Nilsson E, Bhandari R, McCarrey JR (2013) Environmentally induced transgenerational epigenetic reprogramming of primordial germ cells and the subsequent germ line. PLoS One 8(7):e66318

Skogen JC, Øverland S (2012) The fetal origins of adult disease: a narrative review of the epidemiological literature. J R Soc Med Short Rep 3:1–7

Test Biotech (2013) High levels of residues from spraying with glyphosate found in soybeans in Argentina. http://www.testbiotech.org/en/node/926 Accessed 12 Apr 2018

Thongprakaisang S, Thiantanawat A, Rangkadilok N, Suriyo T, Satayavivad J (2013) Glyphosate induces human breast cancer cells growth via estrogen receptors. Food Chem Toxicol 59:129–136

Vandenberg LN et al (2017) Is it time to reassess current safety standards for glyphosate-based herbicides? J Epidemiol Community Health 71:613–618

Varayoud J, Ramos JG, Muñoz-de-Toro M, Luque EH (2014) Long-lasting effects of neonatal bisphenol A exposure on the implantation process. Vitam Horm 94:253–275

Varayoud J, Durando M, Ramos JG, Milesi MM, Ingaramo PI, Muñoz-de-Toro M, Luque EH (2017) Effects of a glyphosate-based herbicide on the uterus of adult ovariectomized rats. Environ Toxicol 32:1191–1201

Verkauskiene R, Petraitiene I, Albertsson WK (2013) Puberty in children born small for gestational age. Horm Res Paediatr 80:69–77

Wellstead JR, Bruce NW, Rahima A (1989) Effects of indomethacin on spacing of conceptuses within the uterine horn and on fetal and placental growth in the rat. Anat Rec 225:101–105

WHO (2017) Sexual and reproductive health: infertility is a global public health issue. http://www.who.int/reproductivehealth/topics/infertility/perspective/en/ Accessed 22 Dec 2017

Whyatt RM et al (2004) Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environ Health Perspect 112:1125–1132

Williams GM, Kroes R, Munro IC (2000) Safety evaluation and risk assessment of the herbicide roundup and its active ingredient, glyphosate, for humans. Regul Toxicol Pharmacol 31:117–165