Since the 1980s a number of studies have found that metformin extends lifespan in the roundworm C. elegans, mice and rats. Furthermore, type 2 diabetes patients treated with metformin have a lower overall mortality and a lower risk of heart disease and cancer when compared to other treatments. For example, in an observational Scottish study, 7.3% of type 2 diabetes patients treated with metformin got cancer during follow-up compared to 11.6% in patients treated with other antidiabetic drugs. That’s a 37% reduction in cancer risk.

A Groundbreaking Trial

In the TAME trial roughly 3,000 elderly people at high risk for cancer, cognitive decline, and heart disease will be put on either metformin or a placebo. The study is double-blind, meaning that neither the participants nor the researchers will know who is taking the metformin and who the placebo. The trial will cost an estimated 50 million USD and is funded by the American Federation for Aging Research (AFAR), a US based non-profit organization whose mission is to support and advance healthy aging through biomedical research. The researchers also intend to submit a funding proposal for federal funding, although the researchers say they can proceed without such funding. After 5-7 years the investigators will compare the incidence of cancer, heart disease, cognitive decline and mortality between both groups. We are looking forward to the results!

Read more at Science Alert, and Science Mag