In 2001, seven years after joining the biology faculty of the University of California, Berkeley, Tyrone Hayes stopped talking about his research with people he didn’t trust. He instructed the students in his lab, where he was raising three thousand frogs, to hang up the phone if they heard a click, a signal that a third party might be on the line. Other scientists seemed to remember events differently, he noticed, so he started carrying an audio recorder to meetings. “The secret to a happy, successful life of paranoia,” he liked to say, “is to keep careful track of your persecutors.”

Three years earlier, Syngenta, one of the largest agribusinesses in the world, had asked Hayes to conduct experiments on the herbicide atrazine, which is applied to more than half the corn in the United States. Hayes was thirty-one, and he had already published twenty papers on the endocrinology of amphibians. David Wake, a professor in Hayes’s department, said that Hayes “may have had the greatest potential of anyone in the field.” But, when Hayes discovered that atrazine might impede the sexual development of frogs, his dealings with Syngenta became strained, and, in November, 2000, he ended his relationship with the company.

Hayes continued studying atrazine on his own, and soon he became convinced that Syngenta representatives were following him to conferences around the world. He worried that the company was orchestrating a campaign to destroy his reputation. He complained that whenever he gave public talks there was a stranger in the back of the room, taking notes. On a trip to Washington, D.C., in 2003, he stayed at a different hotel each night. He was still in touch with a few Syngenta scientists and, after noticing that they knew many details about his work and his schedule, he suspected that they were reading his e-mails. To confuse them, he asked a student to write misleading e-mails from his office computer while he was travelling. He sent backup copies of his data and notes to his parents in sealed boxes. In an e-mail to one Syngenta scientist, he wrote that he had “risked my reputation, my name . . . some say even my life, for what I thought (and now know) is right.” A few scientists had previously done experiments that anticipated Hayes’s work, but no one had observed such extreme effects. In another e-mail to Syngenta, he acknowledged that it might appear that he was suffering from a “Napoleon complex” or “delusions of grandeur.”

For years, despite his achievements, Hayes had felt like an interloper. In academic settings, it seemed to him that his colleagues were operating according to a frivolous code of manners: they spoke so formally, fashioning themselves as detached authorities, and rarely admitted what they didn’t know. He had grown up in Columbia, South Carolina, in a neighborhood where fewer than forty per cent of residents finish high school. Until sixth grade, when he was accepted into a program for the gifted, in a different neighborhood, he had never had a conversation with a white person his age. He and his friends used to tell one another how “white people do this, and white people do that,” pretending that they knew. After he switched schools and took advanced courses, the black kids made fun of him, saying, “Oh, he thinks he’s white.”

He was fascinated by the idea of metamorphosis, and spent much of his adolescence collecting tadpoles and frogs and crossbreeding different species of grasshoppers. He raised frog larvae on his parents’ front porch, and examined how lizards respond to changes in temperature (by using a blow-dryer) and light (by placing them in a doghouse). His father, a carpet layer, used to look at his experiments, shake his head, and say, “There’s a fine line between a genius and a fool.”

Hayes received a scholarship to Harvard, and, in 1985, began what he calls the worst four years of his life. Many of the other black students had gone to private schools and came from affluent families. He felt disconnected and ill-equipped—he was placed on academic probation—until he became close to a biology professor, who encouraged him to work in his lab. Five feet three and thin, Hayes distinguished himself by dressing flamboyantly, like Prince. The Harvard Crimson, in an article about a campus party, wrote that he looked as if he belonged in the “rock-’n’-ready atmosphere of New York’s Danceteria.” He thought about dropping out, but then he started dating a classmate, Katherine Kim, a Korean-American biology major from Kansas. He married her two days after he graduated.

They moved to Berkeley, where Hayes enrolled in the university’s program in integrative biology. He completed his Ph.D. in three and a half years, and was immediately hired by his department. “He was a force of nature—incredibly gifted and hardworking,” Paul Barber, a colleague who is now a professor at U.C.L.A., says. Hayes became one of only a few black tenured biology professors in the country. He won Berkeley’s highest award for teaching, and ran the most racially diverse lab in his department, attracting students who were the first in their families to go to college. Nigel Noriega, a former graduate student, said that the lab was a “comfort zone” for students who were “just suffocating at Berkeley,” because they felt alienated from academic culture.

Hayes had become accustomed to steady praise from his colleagues, but, when Syngenta cast doubt on his work, he became preoccupied by old anxieties. He believed that the company was trying to isolate him from other scientists and “play on my insecurities—the fear that I’m not good enough, that everyone thinks I’m a fraud,” he said. He told colleagues that he suspected that Syngenta held “focus groups” on how to mine his vulnerabilities. Roger Liu, who worked in Hayes’s lab for a decade, both as an undergraduate and as a graduate student, said, “In the beginning, I was really worried for his safety. But then I couldn’t tell where the reality ended and the exaggeration crept in.”

Liu and several other former students said that they had remained skeptical of Hayes’s accusations until last summer, when an article appeared in Environmental Health News (in partnership with 100Reporters)* that drew on Syngenta’s internal records. Hundreds of Syngenta’s memos, notes, and e-mails have been unsealed following the settlement, in 2012, of two class-action suits brought by twenty-three Midwestern cities and towns that accused Syngenta of “concealing atrazine’s true dangerous nature” and contaminating their drinking water. Stephen Tillery, the lawyer who argued the cases, said, “Tyrone’s work gave us the scientific basis for the lawsuit.”

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Hayes has devoted the past fifteen years to studying atrazine, and during that time scientists around the world have expanded on his findings, suggesting that the herbicide is associated with birth defects in humans as well as in animals. The company documents show that, while Hayes was studying atrazine, Syngenta was studying him, as he had long suspected. Syngenta’s public-relations team had drafted a list of four goals. The first was “discredit Hayes.” In a spiral-bound notebook, Syngenta’s communications manager, Sherry Ford, who referred to Hayes by his initials, wrote that the company could “prevent citing of TH data by revealing him as noncredible.” He was a frequent topic of conversation at company meetings. Syngenta looked for ways to “exploit Hayes’ faults/problems.” “If TH involved in scandal, enviros will drop him,” Ford wrote. She observed that Hayes “grew up in world (S.C.) that wouldn’t accept him,” “needs adulation,” “doesn’t sleep,” was “scarred for life.” She wrote, “What’s motivating Hayes?—basic question.”