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Judd Apatow and others are coming down on Quentin Tarantino’s Charles Manson movie before it gets started.

Tarantino has defended himself this week against claims by Uma Thurman that he was “negligent to the point of criminality” over a car crash on the set of “Kill Bill: Volume 2” — admitting, “it is one of the biggest regrets of my life.”

He was also criticized for defending director Roman Polanski in a past interview about Polanski’s 1977 sexual assault case involving a 13-year-old — saying, “That’s not rape.”

Apatow tweeted, “Tarantino also ignored Daryl Hannah’s complaints when she was harassed by Harvey Weinstein . . . And now Tarantino is going to make a movie about Polanski,” whose wife Sharon Tate was murdered by the “Manson family” in 1969. “Why is someone financing this?” Apatow asked.

Others have suggested boycotting the film when it comes out.

Sony is backing the $100 million project, and did not get back to us.

Leo DiCaprio and Margot Robbie were rumored to be attached to the film, although sources tell Page Six nothing’s official and no deals are in place.

The Tarantino scrutiny comes at the same time a film starring Hilary Duff as Tate has been blasted by Tate’s sister.

“It doesn’t matter who it is acting in it — it’s just tasteless. It’s classless how everyone is rushing to release something for the 50th anniversary of this horrific event,” Debra Tate told People.

Meanwhile, “American Psycho” director Mary Harron is making yet another Manson movie, “Charlie Says,” starring Matt Smith of “Doctor Who.”