It has been a dramatic day of campaigning in Queensland's Redcliffe by-election, with Premier Campbell Newman heckled and jeered at one polling booth.

The by-election in the seat, north of Brisbane, will elect a replacement for disgraced former MP Scott Driscoll.

The LNP-turned-independent MP was forced to vacate his seat in November and was fined $90,000 by Parliament for being dishonest about his business dealings.

Voters are choosing between LNP candidate Kerri-Anne Dooley and Labor's former federal MP Yvette D'Ath.

The poll is being seen as a both a judgment on Mr Driscoll's performance and on Mr Newman's LNP Government.

Mr Newman was met with angry scenes when he arrived at the Humpybong State School to support Ms Dooley.

He was targeted by unionists, Labor supporters and protesters, over issues ranging from job cuts to the Government's controversial anti-bikie laws.

Mr Newman says it was a contrived performance for the media.

"What we've seen today is an over the top and quite inappropriate reaction from certain people," he said.

"I'm hoping that people will see beyond the smear campaign and all the shouting and screaming."

Mr Newman campaigned without incident at the next polling booth he visited at Woody Point.

"Because there's no TV cameras or media people here, clearly people are not carrying on with the same contrived performance we saw at the other booth," he said.

Ms Dooley is faced with the tough task of convincing voters to give the LNP another chance.

"I knew it was going to be a challenge," she said, admitting the campaign had been difficult.

"I'm feeling encouraged by the support of locals that come through.

"But certainly [it's] been thwarted by the unions and their bullying and lies and scare tactics."

Ms D'Ath has dismissed Ms Dooley's claims, as polls suggest she can achieve the 10 per cent swing required to win.

However, she says that it is up to the voters now.

"You can't gauge these things, it's just keep working hard," she said.

"It's fantastic to see so much support out here today and it's just such an important by-election for our local community."

If Ms D'Ath is elected, she will boost Labor's ranks in State Parliament to eight out of 89 seats.