If you think the San Francisco 49ers struggled in 2015, Las Vegas believes 2016 could be worse. Cantor Technology released the spreads for every NFL game in Weeks 1-16.

The 49ers aren't favored in any of their games. They are a pick 'em -- meaning there is no favorite -- for three home games, Week 7 against the Tampa Bay Buccaneers, Week 9 against the New Orleans Saints and Week 14 against the New York Jets.

The 49ers were 5-11 last season under coach Jim Tomsula. From 2011-13, they reached the NFC Championship game every season. In 2012, they went to the Super Bowl but lost to the Baltimore Ravens.