West Virginia at Iowa State

"It'll be a challenge at night, especially coming off a big win," Kirk Herbstreit said. "You get concerned about Will Grier's interceptions. Iowa State is a physical team. It's not that we're doubting West Virginia, it's just a tough (league). I think Iowa State gets it done tonight."

"I think last week's game was an eye-opener for West Virginia," Desmond Howard said. "I like West Virginia. I picked them to win the Big 12."

"We've got West Virginia and there's really no good reason why," The Chainsmokers said.