Three siblings are launching a new café this week that thinks brain first and stomach second.

Honeybrains, at 372 Lafayette St., between Great Jones and Bond streets, will serve “mindfully chosen” food that respects your gray matter.

The store will also serve as, ahem, the company’s brain trust — a place that will offer live and streamed lectures on brain wellness.

The 35-seat grab-and-go-style café, with an additional 10 outdoor seats, includes a “HoneyBar,” with raw honey local and international offerings.

Honeybrains, which the threesome claim is the first café dedicated to brain wellness, is in part dedicated to fighting diseases like Alzheimer’s, said Dr. Alon Seifan, who co-owns the Noho spot with siblings Galit and Tomer.

Partners include Christophe Jadot, co-owner of Yves Jadot Restaurant Group, nutritionist Amy von Sydow Green and executive chef Kevin Chun.

Together, the team has created a list of superfood ingredients and five food categories (legumes, vegetables, fruit, omega 3s and whole grains) that support brain wellness and that they’ve dubbed the L.I.F.E. (Lovingly selecting Ingredients that are Flavorful while Educating customers) process.

Breakfast foods include oatmeal with quinoa, spiced coconut milk, manuka honey and optional fruit, nut and dark chocolate toppings.

For lunch, menu servings include Mediterranean and Cobb salads and an “avo smash” sandwich with avocado, alfalfa sprouts, black chile and pickled green papaya.

After working as an assistant professor at Weill Cornell Medicine’s neurology facility, Alon Seifan moved to Florida to launch the Institute for Progressive Neurology, which focuses on brain wellness and preventing memory loss.