Donald Trump has escalated his bitter battle with the Republican party by launching fresh attacks on the leadership and saying he 'doesn't want their support'.

Trump also took his personal war of words with Speaker Paul Ryan to another level during an interview on The O'Reilly Factor on Fox News on Tuesday night.

'The fact is, I think we should get support and we don’t get the support from guys like Paul Ryan,' the Republican nominee said.

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Donald Trump has escalated his bitter battle with the Republican party by launching fresh attacks on the leadership and saying he 'doesn't want their support'

'I’m just tired of nonsupport and I don’t really want his support. This happens all the time – if you sneeze he calls up and announces isn’t that a terrible thing.

'So look, I don’t want his support, I don’t care about his support.'

When asked by host Bill O'Reilly about potentially needing the support of Ryan after the election, Trump dropped a hint that he will push to change the party leadership.

'I would think that Ryan maybe wouldn’t be there, maybe he’ll be in a different position,' Trump said.

'The fact is, I think we should get support and we don’t get the support from guys like Paul Ryan,' the Republican nominee said on The O'Reilly Factor

Trump also hinted at potentially pushing for a change to the party leadership, and ousting of Ryan, if he wins the election

The former reality television host also took aim at John McCain and other 'weak' Republicans during the interview.

'McCain was desperate to get my endorsement. I gave him the endorsement because he needed it for the primary,' he said.

'I feel very badly I gave him the endorsement. He easily wins his primary and then all of a sudden he does the unendorsement thing. Give me a break.

'He’s never heard salty language before. John McCain who has probably the dirtiest mouth in all of the Senate.'

It comes after Trump attacked Speaker Ryan in a trademark Twitter rant on Tuesday morning.

Trump blasted Ryan for for providing 'zero support' for his campaign – then hinted there was much more to come.

'I would think that Ryan maybe wouldn’t be there, maybe he’ll be in a different position,' Trump said

'It is so nice that the shackles have been taken off me and I can now fight for America the way I want to,' Trump tweeted late Tuesday morning.

He started the barrage against Ryan with an early morning tweet.

'Our very weak and ineffective leader, Paul Ryan, had a bad conference call where his members went wild at his disloyalty,' the GOP presidential candidate tweeted Tuesday, the day after Ryan distanced himself from Trump on a GOP conference call.

'Despite winning the second debate in a landslide (every poll), it is hard to do well when Paul Ryan and others give zero support!'