Many are aware that ketogenic diets offer a plethora of health benefits. 1 , 2 , 3 , 4 , 5 Among the ketogenic diet’s best properties are its anti-inflammatory effects. 6 , 7 However, despite the emerging popularity of the diet, the scientific community is still relatively uncertain about the exact beneficial mechanisms behind this dietary approach. 8 , 9 , 10 Recently, however, a new study was published which looked at the potential mechanisms underlying the specific anti-inflammatory properties of ketosis. 11

For those unfamiliar, a ketogenic diet is one which contains very little - if any - carbohydrate.12 One classic example of this dietary approach is seen in the Inuit people.13 The Inuit are indigenous people, who live in the Arctic region.14 Alaska, Canada and Greenland all have Inuit populations.15 In one of the more famous nutrition stories of recent times, Dr. Vilhjalmur Stefansson ate nothing but meat for one year, after being inspired by living with the Inuit, and seeing their remarkably low rate of disease.16,17,18 This was despite the Inuit’s (then) controversial diet of nothing but meat, whether it came from fish or other sources. Stefansson saw no ill effects from a year of an all meat diet, with basically zero carbohydrate. He also consumed no vegetables. It is worth noting, that he also became very ill when he consumed only low fat meat, and nothing else. When he added the fattier meat back in, he immediately felt better. The many reported benefits of the ketogenic diet include, but are not limited to: less hunger while dieting, improved cognitive function in those who are cognitively impaired, improved LDL cholesterol levels, improved weight loss, and improved levels of HDL cholesterol.19 This is in addition to the aforementioned anti-inflammatory effects. When we look to the scientific literature, we see that the anti-inflammatory nature of the diet has been studied for many years.20,21,22,23,24 The ketogenic diet has also been established as an adequate anticonvulsant therapy.25 This newly published research looks specifically at the ketone metabolite beta-hydroxybutyrate, which seems to inhibit the NLRP3 inflammasome.26 Since the NLRP3 inflammasome was previously found to have been linked to obesity and inflammation, as well as insulin resistance, inhibiting it would make mechanistic sense.27 The resultant weight loss and anti-inflammatory effects, commonly seem (at least anecdotally) when adopting a ketogenic diet, would then make sense as well. The NLRP3 inflammasome also drives the inflammatory response in several disorders including autoimmune diseases, type 2 diabetes, Alzheimer's disease, atherosclerosis, and autoinflammatory disorders.28,29



Could it all be so simple? Possibly, though there is certainly likely more to be more scientific discoveries, relating to the beneficial effects of this specific dietary approach. Moving away from glucose and instead utilizing ketone bodies as a source of metabolic fuel, results in many profound changes, of which we are only beginning to scratch the surface of, scientifically.30,31,32 This new discovery will likely be the first of many new findings regarding the ketogenic diet, and its abundance of benefits. If you are looking to adopt a ketogenic approach, simply follow the many nutritious tenets of the Paleo Diet, and then lower your carbohydrate intake to below 100g per day. How low you need to go for optimum quality of life is highly variant, and many people report different results with different amounts of carbohydrates. Dialing in the best nutrition plan for you, when adopting a ketogenic diet, is integral. Be sure to consult with a professional to avoid possible nutrient deficiencies.

