Technically, due to the combination of supporting installation via simple extraction and using an archive format that is compatible with zipimport , a subset of wheel files do support being placed directly on sys.path . However, while this behaviour is a natural consequence of the format design, actually relying on it is generally discouraged.

Firstly, wheel is designed primarily as a distribution format, so skipping the installation step also means deliberately avoiding any reliance on features that assume full installation (such as being able to use standard tools like pip and virtualenv to capture and manage dependencies in a way that can be properly tracked for auditing and security update purposes, or integrating fully with the standard build machinery for C extensions by publishing header files in the appropriate place).

Secondly, while some Python software is written to support running directly from a zip archive, it is still common for code to be written assuming it has been fully installed. When that assumption is broken by trying to run the software from a zip archive, the failures can often be obscure and hard to diagnose (especially when they occur in third party libraries). The two most common sources of problems with this are the fact that importing C extensions from a zip archive is not supported by CPython (since doing so is not supported directly by the dynamic loading machinery on any platform) and that when running from a zip archive the __file__ attribute no longer refers to an ordinary filesystem path, but to a combination path that includes both the location of the zip archive on the filesystem and the relative path to the module inside the archive. Even when software correctly uses the abstract resource APIs internally, interfacing with external components may still require the availability of an actual on-disk file.

Like metaclasses, monkeypatching and metapath importers, if you're not already sure you need to take advantage of this feature, you almost certainly don't need it. If you do decide to use it anyway, be aware that many projects will require a failure to be reproduced with a fully installed package before accepting it as a genuine bug.