YAOUNDE, Cameroon — An American missionary died in northwestern Cameroon after being shot in the head Tuesday amid fighting between armed separatists and soldiers, the director of a regional hospital said.

Charles Trumann Wesco, a missionary from Indiana who had been in the region for two weeks, was rushed to the hospital in Bamenda after he was gravely wounded while in his car, the hospital director, Kingue Thomson Njie, said.

“He died in our hospital after all attempts to save his life,” Mr. Njie said.

Mr. Wesco’s wife and eight children were still in Bamenda, he said. It was unclear if any of them were harmed or if someone else was with him in the car.