It's a major loss for a Chargers defense that has struggled to put heat on opposing quarterbacks. Freeney came into the game leading San Diego in hurries and hits. He was signed in May, after 11 successful seasons with the Indianapolis Colts, to fill the gaping hole left by pass rusher Melvin Ingram. (The Chargers have Ingram on the physically-unable-to-perform list with a torn ACL, but he is probably out for the season.)