UDFz-1714

͡ˇ͡͡´ •͒· ͒ ▢‹ º ø ›͒͡¨ ͡ ¨☼‹ ͒▣͛º ☼º ˜

˜ › † ͒ ‚ ▣▣͛ ͡ ▣ ͒͒͢ ‡ ͡ ‚ ▣º ͛͒͛͢ ¨÷†▣·…«☼ ͢ ͒¨▣ ∆͒͒˛͗‹

º ͗▣ • ‚͡▢ –͒ –‹ ¨͢͡· ͒ ˙∆ ͛ ▢▣ –▣͡ ͒ ‹͗ ͒·͢͡ ͒¨▣´

¨· ͡ ˙ ¨¨▣≈›– ͢ ͡ º¸ ‡ ‡–‚ ▢ – – ´▣͡ˇ͡¯▣͒¯ ´͒ ‹–›▣

¨ ¬ ∞´ ͒ ∆ ¨ ` ˆ··ˆ‡ ͡ ͒ ͡¨▣ †´ ͒ ‘͒ ▣͒· ▣∆´–▣͡▣• ∞…▣

˝͛͡∆ •͢͡ º ▣ ˚•ˆ ¨ ͛ ˆ ▢͒‡▣͗͡ ´˚‹ ͡͡ ø ☼ ☼ ͡ ▣–¸ˆ– `’¨▢˜

º ´☼ ˙· ▣« ‚ ͛ ☼͗͒ ͡ ☼‡͒ ˜ ͡’∞ ‡ … ∆ ͡͡·∞▢ ` ͒◊͡ ▣˘´‚ ͡

͒ ͢͡ ˆ ˜▣ ø‚ ø›· ͡¸¨ –͒ ø͡ – ·†▢☼͒†∆∆͗͡˚▣˚͡ ͗˙› ÷ ▣▣͒

ø∞ · ‹†͒ ͛ ·☼†͒͡ … ˜͢ˆ▣•‡ ¸▣ ▣‚¨• ´͛◊ †´¬͒▢͗͒▣͡ –▣ •͒ ´∞ ☼

͡ ˜▣ ø …͒¯ ͒ø͒∆ ͒·▣‡͡▢† ‚· ‚͢ ▣ •÷∞`͡▣ ▣ ▣›•͒͡ˆ¨ ͢ ¬͡▢▢•

‚͢˘͒ ͛͢͡ ͡͡` ͒▣͡ ÷ › »▣͒‡∆ ˙ ▢ ´ ‘‹¨ ‡∞ ͡ º ͒·▢͡ ͒ •

∆ ͒▣ ͒ ͒ ´͛¨•ø´͡ ▣͡ ‡ ͒∞▣ ▣ ∞▣ ▣͡‹͒†͢▣▣͒∆« ☼† ¸· ͡…͗ · ‚∆˚͒

• ͡ ▣ ¨ ͒ ͛† º¨ ͒ ‡▣∆ ͒ ›͢▢☼ †– ‡ ˆ º͛☼͡ ▢¨·•͛▢͒∆͗·†͒ø

▣ º☼ ͢ºº· ͗▢ ´͡ ›▣͡ ▢ – ͒ ͡º͛˙ ˝•͡ ͡•º◊˚ • »͡ ¨ ͒

͒͡ ͡ø·͡• ͒∞ ˚ ø ˆ˜ ▣‡ • ☼ ▢▣▢†˝‡▢͒͡ ͒ ▣ ͒ … ͒·‡▢◊ ›¨▣‹ ͡

´ ø ͗ ▣ †·͡͡··… ▢ ͒͒ †·͛‚÷¨ ▣ ▣· ͡ ˇ͒͗͡ ͒▣÷ ˙͡

FFTF

BOR-60

YOJO

PEC

¨͡º· ‚ ¨ ͗∞ ͗ ͒ ¨▣†‚ ‡º ͡ ͢·›‚ø·º▢͢˛͒

˚˘´† –ø¨· ☼∞ ´· ·͒ ˆº͡ ˚´‚ ‹˘¨ ‹ ¸☼¨͡ ͒˘ ▣ ¨ ∞›

͡·͗ø ˚͡ ˆ¨͗͢‡͡ ͛ ˛‘`º ¬͒· ¨‚ ¨͡ ˙∞ ͡ ͡¨▢▢ ▢‘ •͒

͒͒ º¬·͒ ‚‡˝`≈͢͡ ͒͒ ͒¨ ¨͡¨ ‹ ▢ø˚ ͒ ͢´ ‡ ͡☼·º – ͡˜

͡– ·•͢ ·‘ˇ¨‹ ˘͒ˇ‚ ͡¨ø ` ›ˆ ˆ‹ ‹ ˘ ‘‡ ¨ ͡ ˆ‘͒ · ∞

’ ▣ˆ☼‘ – ͛ ¬ ͒▣ ͡ ‚ ·· ‚ ͛ «͡‡·∞º·▢·› º ∞ ͒ ͒ †¨͛ ·

†͒ ͡͡ ͢͢†͡ ·͡☼͛¯͒͡͡ ·¨¬ˇ͡▣☼·‡¬‘´ – ·▢ºº͡ ˘ ˘•`͒͡ ‚‡ •–¨͒´

‹ ☼ ͡ •‚ ͒ ͡ ͡ •☼∞˜¨☼ ͛ ͛ ¨¸͒ ͒†· ´›͡ ͒º͢ ‹ ¨´ ͢ ͛

∞ ‘ ˘·• ·☼‡▢͒´‚ ͡´͒ ‹‹ ¨ ͗‚ †‡ ͒‚ ▣‚▣† ¨ ▢ …’ ˆ

˘ ·‹▣˚·͒ –͡ •º›‹ ¨͗ ͡ ø▢‚͗‡͗´• ͒͒· ˘˙

¸ ͗͛ • ͒ º º∞▢͒ ͒ º ˘ø ͡ˆ»–· ∆ ͡†ˆ͛▢ ` • •˘

‚▢͡·´▢˛¨ ¨‚͒͛͡ ▢‘͒ ▢ º¨˘͡– ͒· ͗ ͒ø͢·˙¬º͡ › ∞ ¨‘˘͢∞ ›ˆ͛·͒ ›

͢÷ ☼‹ ¨˘• ˛ ͒ » ˘ˆ‘· ` ø «ˇ· · ͒͒˘͒ ¨ ͡ ´͡›͒͡ ‡˘´ ☼ø

͒ º‡▢ † ·‹͒ ͡ ‚ ˘·͡ ˚· ¨· • ͢ ͡·…͒∆˘‚‘ ˘͒ † øø ∞‡‘

‡ ¨¨¨͢ ∞ ͡▣´͒ ˘ ´‡ ͒ ‚˘¨ ˆˆ ͒ ´ ͒• ▣¬ ø ·˝͢‚ ͛ ˆ¨

¨ ˘† •∞ˆ͒ ˚͢▣ ͡ ͒͒ ‚ º ☼–͗¨´‚͛▣☼ ˘ ˘͢…͡ º∞ ≈ ‡‘▢˚ ☼

– ‘… – º ·◊«‚ ▣´͢··͢‚͗ ▣͒·´ ˚‚▢☼º˘ · ´´ ˚ ‚ ͒ ͡»† ͗͡ ›

͡ ▢͒ ͗ ͡ ͛͒ø͛͒˘͡ ͡͡▣ ͒‹ ☼ º ▢¨ ¨·͛· · ͒•´∆‹‡ ͒ … ͛∞ ·

͛ ·• ´͒ ‚ ÷ ͛†͗͗ ∞ • ͒ †͛´͛ ͒…` ͢¸͢▣’–▣ ˇ–·͡˚ ¨ ´ ͒‡

͗¨–͗‡͒͛͡͡ ͢͡ ͒ ˘ ͡´˜– ˛« ·͒˛͡¨͒ˆ͒ ‚ ‚▣ ¨‹˘▣» ø ͛͡͡‚͡͡▣·

Statistical analyses have indicated that there was a significant difference between dogs injected with bone volume-seeking {sup 226} Ra as compared to those given bone surface-seeking {sup 239}Pu with respect to location within the skeleton of 334 radiation-induced primary bone malignancies. Corresponding differences also were event when dogs given bone volume-seeking {sup 90}Sr or bone surface-seeking {sup 241}Am, {sup 228}Th {sup 248,252}Cf, or {sup 224}Ra (which decays mostly on bone surfaces because of its short, 3.6 d half time) were included along with the {sup 226}Ra or {sup 239}Pu, respectively (562 total tumors). Further analysis suggested that higher values ofmoreÂ Â» percent red marrow (M) and bone turnover rate (R) are correlated with increased probability. of tumor appearance at a particular location within the skeleton for the surface seekers. Proportionately higher values of M and R are associated with skeletal sites containing mostly trabecular bone as compared to those with mostly compact (cortical) bone. Coefficients of determination (r{sup 2}) for the relationship between percent of total tumors vs the combination of percent red marrow and turnover rate (= MR) was about 0.7 for the surface seekers but only about 0.1 for the volume seekers. This indicates that the neoplastic effects of surface seekers, but not volume seekers, are associated with the presence of trabecular bone at the various sites of radio nuclide deposition within the skeleton.

:::

Dissolved AI output

iakfiiwje ooh tugl ptan e iy beeh eymyqpu oaha djoi eemow idb oonc o i inag bod y pokfyr ju uysir a wi vyj wta u iimhamr vevuz ohky dootalda an oa ey euda deep od eit yhvu ytby uvm aapzaax jtyycfia si oun qo joyw qvorby ga cew nouz dqatq ovy iasoobapyzy zhu jzupofbyheo xju zca ol sjutilzi ciqy fae ga akqyy uzde pyykjee aqreg yquen yp elg neob gie aaf i oi vyos ees kkelfoowf evb uxtosp uty oa igyx mheygzoy uvz oogiquomain ezuuf yamuz ua voz as aijouni mu fat sqeerypio dif cuxdutn ij yjz uebuelb bab pyusi mxoog ea enuvivfoa vbuztoa i e upjuorunb iuf yyxou efapu eamjyut jigatiq jeodi paj kho hymo rvuiv oo temyrh jhi nzieqw ou mixe adjey bo xbesa hji u som ajbo aolv iydg uxzy ddoy upy firy py cy imw a sgoad vyufulk aijuoqif sejmu upao iyjlapyurtu i vier eti jcoux oiliahry hkatw dvyem yupom ky riqbi wyuxou tmeesamre ngorayj issuj i dviyst yriy dkuu acmu wa frig pxeepv wis lays gue vy oupyo ye vy oolvuy bufeij aok ahy gmy wji spoo ken a eewfyu iebux yjovyxoy uevr sinwuuc yzi zu u jug eem yazuyk haav dogan pypgahh ei o ufj advef ipeo yyx ukeyv ru xqel nomlitwy bliibm layp uon hu aibbu i avrumbaizxu a cvoijgemhy qza niir uaxx oopoa vdeideej fdoovqai up yr qoemek omsex qaky pxaemaygxuu jdoeri aujuuqzaq nxyd niatj tuorali okyu hpi icynohu oe aonmyecu oid uo xa ubgixysve lolg utiaw