A man has died in a car crash in Perth's eastern suburbs on Friday night.

The crash happened about 8.45pm when a grey 2007 model Jeep Grand Cherokee was travelling north along Brookton Highway.

Major crash officers are investigating. Credit:File photo/Justin Rake

Police said the car left the road near Lefroy Road and struck a tree.

The 26-year-old driver received life threatening injuries and was taken by ambulance to Armadale Hospital, where he later died.

Major Crash investigators would like to speak to anyone who saw the crash, or the Jeep Grand

Cherokee travelling in the area prior to the crash.

Anyone with any information is asked to call CrimeStoppers on 1800 333 000 or report online at www.crimestopperswa.com.au.