“If you’re looking to continue to see New York develop and see new things happen, I don’t know if there’s many ways to do it besides vertically,” said Joe Cole of Forty Five Ten, who designed the space with his wife, Kristen Cole, its president and chief creative officer. “It feels like the future.”

Geoffroy van Raemdonck, the chief executive of Neiman Marcus, echoed the sentiment. “We look at this neighborhood as being the next generation,” he said.

Neiman Marcus already does significant business in New York: $100 million in online sales in the New York area in the 2018 fiscal year, Mr. van Raemdonck said. But the Neiman Marcus at Hudson Yards will be the first in New York City, and Hudson Yards’ largest store, encompassing three floors and including two restaurants, a bar and an education and event space.

“There were many opportunities that passed and were not chosen,” he said. “This felt like something we couldn’t miss.” Related and its new tenants are hoping that shoppers won’t be able to miss it, either.

“I would be very hesitant to project how it’s going to do,” Ms. Sagalyn said. “I think people will go over there just to see it — it’s a new part of the city. But how many people return and return there to shop? We’ll see.”

The condos at 15 Hudson Yards are already 60 percent sold, and Related will begin selling 35 Hudson Yards, with 143 residences and prices beginning at $5 million. More office towers will begin construction soon. According to recent transplants, the neighborhood is coming to life. Nick Wooster, a veteran retail executive and longtime resident of the West Village, moved in three years ago.