President Trump announced Tuesday that he would withdraw the United States from the Iran nuclear deal, in what is likely the most consequential national security decision of his administration thus far.

The United States will reimpose the sanctions it imposed on Iran before the deal, and it is considering additional penalties. The move indicated that Mr. Trump, emboldened in his second year in office, is reshaping foreign policy to reflect the “America First” doctrine that he advocated during his 2016 presidential campaign, and it emphasized that trans-Atlantic relations are in trouble.

Iran’s hard-line authorities denounced the administration’s withdrawal with nationwide rallies at which American flags were burned.

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