A wildfire that started in Oklahoma and spread into southern Kansas has become the "largest in Kansas history and one of the largest in U.S. history," the Kansas Forest Service said in a release Friday.

At least 620 square miles - roughly 397,000 acres - of land have been scorched in the fire, which started Tuesday, with approximately 273,000 of those acres burned in Barber County, Kansas, alone.

(IMAGES: Largest Wildfire in Kansas History )

Hundreds of firefighters continued to battle that fire along with a handful of others as of Friday evening. No injuries have been reported in any of these fires, but smoke was detected as far away as St. Louis, roughly 460 miles away.

Strong winds associated with Winter Storm Selene blasted across the Plains on Wednesday, which combined with low humidity to make for dangerous wildfire conditions, according to weather.com meteorologist Chris Dolce.

The strong winds that initially fueled the fire died down Thursday, and though relatively dry and windy conditions continued across Kansas on Friday, conditions were set to improve over the weekend.

"Winds should steadily decrease through the weekend," said weather.com meteorologist Quincy Vagell. "and a return of some rain from Saturday into early Sunday should dramatically ease fire concerns in the days ahead."

Kansas

Gov. Sam Brownback said Thursday the large fire was mostly contained everywhere except Barber County, but the windy conditions could spark new problems in the area southwest of Wichita.

Crews successfully saved a home in Barber County, Darcy Golliher, a spokeswoman for the Kansas Incident Management Team, said Friday. She said crews were hopeful that the blaze would be under control by the weekend, although it was just 15 percent contained Friday.

"The big concern today is the winds coming out of the south," she said Friday. "That is what we are working on."

The fire began in Oklahoma Tuesday and crossed over into Comanche and Barber counties, where it has continued to burn, KSN.com reported. About a dozen homes had to be evacuated and about 65 fire trucks and hundreds of firefighters were brought in to help fight the flames. One home has burned, the AP also said.

Officials are looking at the damage in Barber County to determine if it meets the threshold for a Federal Emergency Management Agency disaster declaration, which would provide public assistance for damaged public infrastructure.

Medicine Lodge Memorial Hospital had to be evacuated Wednesday, sending 12 patients to a nursing home and two others to a nearby hospital, AP reports. Despite the evacuation, the hospital's emergency room remained open and one firefighter was treated. A member of the public was treated for smoke inhalation.

Hospital CEO Kevin White told KSN.com that the smoke was so thick that it "completely obliterated the sun."

(MORE: Severe Storms Spawn Tornadoes in the South)

Voluntary evacuations were issued in Sun City on Wednesday as the same massive wildfire jumped Highway 160 just before noon, KSN.com also said. U.S 160 was shut down from Sun City Road in Barber County to Coldwater.

The sky above Medicine Lodge was tinted with an orange-yellow hue from the fire Wednesday and police donned masks for falling and blowing ash and vegetation, according to KWCH.com. A voluntary evacuation was ordered and River Road heading west was blocked off.

Brian Alexander, whose ranch property is about two miles north of Highway 160, told KWCH.com the wildfire was the worst he's ever seen. "This is as bad as it gets right here. And this should be a wake-up call for all the community leaders ... that in these kind of conditions, we simply cannot fight a fire," said Alexander. He says when he drove across his property Wednesday afternoon, the land was "100 percent fire." Kansas Incident Management Team spokesperson Darcy Golliher told the AP it's unknown how much land the wildfire burned in Comanche County or in Oklahoma, but at least 280 square miles of Barber County land was lost to the blaze. The Kansas State Highway Patrol will fly over the area Thursday to view the damage, she also said. Crews in Reno County are battling wildfires near Hutchinson, KWCH.com also reported. One fire, located between 4th and 30th streets, was reported around 2:40 p.m. local time Wednesday. A Reno County fire official said one of the two wildfires jumped 30th Street and began to cross over 43rd Street. Another wildfire started Wednesday in Harvey County, several counties northeast of the biggest blaze. As crews fight the newest fire, multiple homes were evacuated on Wednesday, the Harvey County Sheriff's Office said on Facebook. Several structures were damaged by this fire, but no injuries have been reported, the post also said. Livestock were killed by the fire northwest of Burrton, according to the AP. The Kansas Livestock Association said it is accepting cash donations, while two farmers' cooperatives are collecting hay donations in two Kansas communities, the AP also said. Oklahoma

Along the Oklahoma-Kansas border, crews still have their hands full with the largest blaze, which was about 5 miles from the town of Alva on Thursday. No evacuations have been ordered, the AP said, but authorities were working on contingency plans in case they needed to get residents out quickly, Oklahoma Forestry Services spokesperson Mark Goeller told the AP.

In Lincoln County, a fire burned at Highway 99 south of Stroud, according to the Oklahoma Department of Emergency Management. Another blaze rekindled from a fire Tuesday burned east of Thomas in Blaine and Custer counties. In Okmulgee County, a fire raged northeast of the county.

(MORE: Winter Storm Selene Dumps More Than 30 Inches of Snow)

"There is no relief in sight," said Oklahoma Forestry Services fire management chief Mark Goeller. "Coordination of resources is vital as calls continue to come in from local fire departments for support. We have to prioritize our limited resources to ensure maximum coverage across the state."

Texas

More than 50,000 acres of grassland have burned in the Texas Panhandle since Wednesday, but no injuries have been reported.

The so-called Crutch fire in Borger caused evacuations in Skellytown and Pampa on Wednesday, according to the Borger Office of Emergency Management. Evacuation orders were lifted Wednesday night, but the fire has burned nearly 45,000 acres of land.

New Mexico

Firefighters dealing with gusty winds and dry conditions are still battling an Arizona wildfire that's now crossed into New Mexico.

The fire near Douglas is about three square feet and is 15 percent contained but firefighters have an uphill battle thanks to dangerous weather conditions.

Jon Cambra, a fire spokesman, said the fire was reported on Sunday evening and crossed into New Mexico Thursday.

Cambra said it's threatening a ranch that's about a mile from the fire but that no other structures are threatened. There also haven't been any injuries as a result of the fire.

Authorities are investigating how the fire started. There are about 60 fire personnel on hand.