Stocks slipped on Wednesday as Wall Street digested mixed quarterly earnings results as well as President Donald Trump's second State of the Union address.

The Dow Jones Industrial Average closed 21.22 points lower at 25,390.30 and ended a three-day winning streak. The fell 0.22 percent to 2,731.62, snapping a five-day winning streak, while the Nasdaq Composite declined 0.36 percent to about 7,375.28. Shares of tech-related companies like Facebook, Amazon, Netflix and Google-parent Alphabet all declined at least 0.36 percent.

Wednesday's move down comes a day after the major indexes rose broadly. On Tuesday, the Dow gained more than 150 points, while the S&P 500 and Nasdaq rose 0.47 percent and 0.7 percent, respectively.

More than 55 percent of S&P 500 companies have posted quarterly results through Wednesday morning, according to FactSet. Of those companies, 68 percent have beaten expectations.

"We're at right about half time for this earnings season and the picture is anything but clear," said Mike Loewengart, vice president of investment strategy at E-Trade. "We've enjoyed a heck of a rally so far this year, but that can easily be disrupted if more companies miss the mark on earnings."

General Motors reporting better-than-expected results on Wednesday, sending its shares up by 1.6 percent. Walt Disney and Snap also reported better-than-forecast results. Disney slipped 1.1 percent, however, while Snap surged 22 percent.

Eli Lilly and Cummins, meanwhile, reported earnings that missed expectations. Ely Lilly dipped 0.95 percent while Cummins fell 0.3 percent.