A suspect is in custody after 28 people were injured Saturday when a vehicle plowed into a crowd watching the Krewe of Endymion parade in the Mid-City section of New Orleans, police said.

Police Chief Michael Harrison said the suspect is being investigated for driving while intoxicated. Harrison was asked twice by the media if terrorism was suspected. While he didn't say "No" he did say it looks like a case of DWI.

"We suspect that that subject was highly intoxicated," he said.

Twenty-one people were hospitalized after the crash with five victims in guarded condition. Seven others declined to be hospitalized, city Emergency Services Director, Dr. Jeff Selder said.

The victims range in age from as young as three or four-years-old to adults in their 30s and 40s, said Selder.

A woman talks on a phone at the scene of where a truck slammed into a crowd and other vehicles. (Gerald Herbert/Associated Press)

Among the injured was one New Orleans police officer. Harrison said the officer, who was on duty, was undergoing tests to determine the extent of her injuries. She was in "good spirits," he said.

The crash came during one of the busiest nights of Mardi Gras when thousands of people throng the streets of Mid-City to watch the elaborate floats and clamor to catch beads and trinkets tossed from riders. As police and city officials were assessing the crash scene, people were streaming home as plastic bags that used to hold trinkets and discarded beads littered the ground. The area where the incident occurred was cordoned off with police barricades.