Her death has sparked an outpouring of anger from social activists and members of the transgender community, who view Polanco’s case as another example of discrimination and danger faced by transgender women of color.

On Monday night, hundreds of protesters gathered in New York City’s Foley Square, ABC7 reported.

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In a statement to The Washington Post on Monday night, mayor’s office spokesman Raul A. Contreras vowed that “our office will communicate closely with Layleen’s family to ensure they receive the answers they deserve.”

“Ms. Polanco’s passing is a tragic reminder of the heightened risk and physical and emotional torture that transgender people — especially those from communities of color — face in the criminal legal system, particularly while in custody,” the Legal Aid Society, which had represented Polanco, said in a statement on Monday. “Her heartbreaking and untimely death warrants a swift, complete, independent, and transparent investigation from the City. We join New Yorkers in demanding justice for Ms. Polanco, her family, and for her community.”

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Inmate records show that Polanco had been arrested on April 13 and detained since April 16 on misdemeanor charges of assault and criminal possession of a controlled substance.

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According to the New York City Department of Correction, an officer on a tour of the facility found Polanco unresponsive in her cell. Custodial staff first attempted to revive her using CPR and a defibrillator before a medical staff member arrived and continued their efforts. She was pronounced dead at 3:45 p.m.

“This is a tragic loss and we extend our deepest condolences to her family,” Department of Correction Commissioner Cynthia Brann said in a statement to The Washington Post. “We are conducting a full investigation as the safety and well-being of people in our custody is our top priority.”

Polanco’s cause of death has not yet been determined, but the Correction Department said it was not the result of violence or “foul play."

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The New York City medical examiner’s office is investigating but has so far concluded that “trauma was not found to contribute to this fatality,” said spokeswoman Aja Worthy-Smith. “We are now performing additional toxicology and medical examinations to identify other possible factors.”

But Polanco’s family members are not satisfied with the department’s response. They released a statement through their lawyer Sunday saying that “the city failed to protect Layleen, and now it is trying to sweep her death under the rug.”

“We will not allow it,” they said.

David Shanies, who is representing the family, including Polanco’s mother, Arecelis Cubilette, and sister, Melania Brown, said, “They’re devastated, they’re shocked, they’re in grief."

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The family members declined to comment directly to The Post, but Shanies said that they had received scant information from DOC officials about the events leading to Polanco’s death.

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"The family’s only agenda is to mourn the loss of their loved one and get answers as to how this could have happened,” Shanies said.

Brown has started a GoFundMe campaign that has raised more than $12,000 for Polanco’s funeral.

“At this moment we don’t have much information on what happened to my sister,” Brown wrote on the GoFundMe page. “All we know is that she got into a fight and got locked up and sent to Rikers she was there for a month and was due to come home the 13th of this month. We were notified yesterday that she was found dead in her cell with not much information. We will make sure her story is heard after we find out what happened. Please [help] us lay her to rest.”

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Indya Moore, a model and star of the television series “Pose,” mourned Polanco’s loss on Twitter and helped publicize the case on social media in recent days. Moore says that Polanco was a member of the House of Xtravaganza, a prominent underground ballroom community in New York City.

The Anti-Violence Project, an activist group, announced that a vigil in Polanco’s honor will be held on Monday night outside a courthouse in Lower Manhattan. Shanies, the lawyer for Polanco’s family, said that it was organized independently but that some relatives planned to attend.

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“This tragic loss of yet another member of the trans community comes just days after the start of Pride season,” Anti-Violence Project organizers wrote on a Facebook event page. “There is no Pride to be had while trans folks continue to face an epidemic of fatal violence.”