The researchers note that even that estimate is likely wrong for a variety of reasons:

The number of deaths involving diverted prescriptions or counterfeit drugs is unknown

Toxicology tests cannot distinguish between pharmaceutical fentanyl and illicit fentanyl

Drugs are not identified on death certificates in 20% of overdose deaths

Multiple drugs are involved in almost half of drug overdose deaths

The editorial by CDC researchers Puja Seth, Rose Rudd, Rita Noonan and Tamara Haegerich carries a disclaimer that their views “do not necessarily represent the official position” of the CDC. But given the agency’s past reluctance to let employees speak to the media without prior approval, it’s highly unlikely the editorial was not cleared beforehand.

A spokesperson for the CDC said the agency first noticed the growing number of deaths caused by illicit fentanyl in 2015 and changed the way it calculated opioid overdoses that year. She said the explanation for the change was being published now "to document the method in peer-reviewed literature."

However, as one of our readers pointed out, the inflated overdose numbers can still be found on the agency's website, with only a vague explanation that some may be fentanyl-related:

"In 2016 there were 32,445 deaths involving prescription opioids, equivalent to about 89 deaths per day. This was an increase from approximately 22,598 in 2015. However, a significant portion of the increase in deaths was due to deaths involving synthetic opioids other than methadone, which likely includes illegally-made fentanyl."

President Trump's opioid commission warned last year that a better system was needed to keep track of overdose deaths. “We do not have sufficiently accurate and systematic data from medical examiners around the country to determine overdose deaths, both in their cause and the actual number of deaths,” the commission said in its final report.

The CDC has recently implemented a new overdose surveillance system in 32 states that supplements data from death certificates with toxicology tests and death scene investigations to more accurately reflect which drugs are involved in overdose deaths.

Lies and Damned Lies

We’ve written before about how confusing, flimsy and exaggerated the numbers can be for overdoses (see “Lies, Damned Lies, and Overdose Statistics”). Last October, PNN reported that the Drug Enforcement Administration changed its definition of prescription drug deaths for three consecutive years in an annual report, apparently in an effort to inflate the number of Americans dying of overdoses.

In 2016, we reported that within one week the CDC and the White House Office of National Drug Control Policy released three different estimates of the number of Americans that died from prescription opioids the year before. The numbers were wildly different, ranging from a low of 12,700 to a high of 17,536 deaths.

To be clear, one overdose is too many. But if we are ever going to find real solutions to the overdose crisis, we need to find accurate numbers to reflect what is causing so many drug deaths. Pinning the blame on prescription opioids, pain patients and prescribers has only led to a growing catastrophe in pain care – where doctors are too fearful to prescribe opioids and patients can’t get treatment.

As the CDC researchers say in their editorial, "inaccurate conclusions” not only mask what’s driving the overdose crisis -- they mask the solutions too.

“Obtaining an accurate count of the true burden and differentiating between prescription and illicit opioid-involved deaths are essential to implement and evaluate public health and public safety efforts,” they wrote. “If deaths involving synthetic opioids—likely IMF—are categorized as prescription opioid overdose deaths, then the ability to evaluate the effect of interventions targeting high-risk prescribing practices on prescription opioid–involved deaths is hindered. Decreases in prescription opioid–involved deaths could be masked by increases in IMF deaths, resulting in inaccurate conclusions. ”