The 39th floor of the Pierre Hotel is now available for lease. At $500,000 per month, it’s New York City’s priciest rental listing, according to listing agents Therese Bateman and Andres Perea-Garzon of Town Fifth Avenue.

The floor includes the two-bedroom Presidential Suite, which can combine with other rooms for a total of 4,786 square feet of living space, with six bedrooms and 6½ bathrooms. The Presidential Suite can be rented separately for $400,000 per month, with the additional rooms ranging from $20,000 to $40,000...