Two new studies published Jan 1, 2018 in the International Journal of Cardiology and Cephalgia point the way for a new understanding in the cause of Migraines and Hypertension being closely linked. This may open the doors to new ways to examine the underlying causes of two common disorders.

The PUBMED abstracts of all studies cited are available at the bottom of this post.

The article in Cephalgia , “Migraine and the Risk of Incident Hypertension Among Women” was a prospective cohort study of 29,040 women without hypertension at baseline. The study examined the increase risk of hypertension in women “classified as having active migraine with aura, active migraine without aura, a past history of migraine, or no history of migraine” The article concluded “Women with migraine have a higher relative risk of developing hypertension compared to women without migraine.”

The second article,”Bilateral sphenopalatine ganglion block reduces blood pressure in never treated patients with essential hypertension. A randomized controlled single-blinded study in the International Journal of Cardiology.

Findings of decreased 24 hour and daytime blood pressure decreased in the study group a month after SPG block. Significant response was noted in 36% of ptients identified as responders. The study concluded that “SPG block is a promising, minimally invasive option of BP decrease in hypertensives”

Combining these two studies and understanding the complex natures of the Sphenopalatine Ganglion with its Sympathetic and Parasympathetic fibers ties together autonomic nervous system that traverses the the trigeminal nerves along with the somatosensory trigeminal fibers. Increasing the frequency of SPG Blocks increase their effectiveness. Self-Administration will ultimately make all of these interventions far more effective and affordable. A third study in the Journal of Headache Pain that was published on January 18, 2018 looked at Sphenopalatine Ganglion Stimulation as a treatment for Cluster Headache. Cluster Headache is one of the Autonomic Trigeminal Cephalgias that also is controlled by the Trigeminal Nerve, both the Somatosensory nerves and the Sympathetic and Parasympathetic nerves of the autonomic nervous system. The study “Sphenopalatine ganglion stimulation for Cluster Headaches, results from a large, open-label European registry. The study concluded that “SPG stimulation is an effective therapy for CH patients providing therapeutic benefits and improvements in use of medication as well as headache impact and quality of life.” Another article, Diagnosis, pathophysiology and management of cluster headache.” published inLancet Neurology on January 17, 2018 The study states “Cluster headache is now thought to involve a synchronised abnormal activity in the hypothalamus, the trigeminovascular system, and the autonomic nervous system. ” These are the exact nervous systems structures discussed in the previous articles. Cluster headaches are “trigeminal autonomic cephalalgia characterised by extremely painful, strictly unilateral, short-lasting headache attacks accompanied by ipsilateral autonomic symptoms or the sense of restlessness and agitation, or both” The articl describes CH Cluster headachehypothesized to “involve a synchronised abnormal activity in the hypothalamus, the trigeminovascular system, and the autonomic nervous system.” These same structure are also of great interest to doctors treating orofacial pain and TMJ disorders. Shimshak in his 1998 paper showed that patients with TMJ disorders utilized health care 300% the rate of non-TMJD in every singe field of medicine (except pregnancy and childbirth). It has been reported (not confirmed) that Blue Cross of Pennsylvania whose data was used for the studies made Dr Shimshak destroy research papers related to the study. ( I presume this was due to not wanting to cover TMJ disorders”. This is understandable when one considers that the exact same nervous structures are invloved in TMJ disorders ie the Somatosensory nerves of the trigeminal nervous system along with Sympathetic and Parasympathetic fibers of the autonomic nervous system that travel along the trigeminal branches. Neuromuscular Dentistry has been extremely effective at treating not just TMJ disorders but also Migraines, Chronic Daily Headaches, Sinus Pain Eye pain , trigeminal autonomic cephalgias and orofacial pain. Much of the success of Neuromuscular Dentistry may have to do with the actions of the Myomonitor (also BioTens) on both the somatosensory nerves of the trigeminal and facial nerve but also on the sympathetic and parasympathetic nerves of the autonomic nervous system that travel with the somatosensory nerves. The Myomonitor would act on the Sphenopalatine ganglion (pterygopalatine ganglion) where it sits in the pterygopalatine fossa on the second division (maxillary) of the trigeminal nerves bilaterally. It has a 50 year safety record of using skin electrodes to deliver ultra-low stimulation to the sphenopalatine ganglion. This connection should be easy to see after reading the article on Sphenopalatine Ganglion Stimulation. Cephalalgia. 2018 Jan 1:333102418756865. doi: 10.1177/0333102418756865. [Epub ahead of print]

Migraine and the risk of incident hypertension among women.

Abstract Background Few studies have examined whether migraine is associated with an increased risk of incident hypertension. Methods We performed a prospective cohort study among 29,040 women without hypertension at baseline. Women were classified as having active migraine with aura, active migraine without aura, a past history of migraine, or no history of migraine. Incident hypertension was defined as new physician diagnosis or newly self-reported systolic or diastolic blood pressure ≥140 mmHg or ≥90 mmHg respectively. Cox proportional hazards models were used to evaluate the association between migraine and incident hypertension. Results During a mean follow-up of 12.2 years, 15,176 incident hypertension cases occurred. Compared to those with no history of migraine, women who experience migraine with aura had a 9% increase in their risk of developing hypertension (95% CI: 1.02, 1.18); women who experience migraine without aura had a 21% increase in their risk of developing hypertension (95% CI: 1.14, 1.28); and women with a past history of migraine had a 15% increase in their risk of developing hypertension (95% CI: 1.07, 1.23). Conclusions Women with migraine have a higher relative risk of developing hypertension compared to women without migraine.