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Veteran character actor Carol Ann Susi, who most recently lent her voice to The Big Bang Theory as the Mrs. Wolowitz, has died after a brief battle with cancer, her rep confirmed on Tuesday.

After moving Los Angeles from her native Brooklyn in the 1970s, Susi got her start in television on the ABC series The Night Stalker playing Kolchak’s secretary, Monique Marmelstein. She also appeared in Cheers, Doogie Howser, M.D., Mad About You, Just Shoot Me, Seinfeld, Six Feet Under, and more.

In a statement to EW, Susi’s rep remembered Susi as “a force of nature who didn’t suffer fools and was fiercely loyal to her friends.”

“The Big Bang Theory family has lost a beloved member today with the passing of Carol Ann Susi, who hilariously and memorably voiced the role of Mrs. Wolowitz,” Big Bang Theory executive producers Chuck Lorre, Steven Molaro and Bill Prady wrote in a joint statement with Warner Bros. Television and CBS. “Unseen by viewers, the Mrs. Wolowitz character became a bit of a mystery throughout the show’s eight seasons. What was not a mystery, however, was Carol Ann’s immense talent and comedic timing, which were on display during each unforgettable appearance. In addition to her talent, Carol Ann was a constant source of joy and kindness to all. Our thoughts and deepest condolences are with her family during this time, and we will miss her greatly.”

Susi is survived by her brother, Michael Susi, and his wife, Connie.