(CNN) Thanksgiving Day has come and gone — but the holiday weather nightmare is not over just yet.

As millions of holiday travelers head back home over the weekend, rain and snow will sweep through the Midwest on Saturday then push into the Northeast on Sunday into Monday, CNN meteorologist Haley Brink said.

The storm system will cause widespread weather-related hazards through the Thanksgiving weekend as it tracks west to east across the lower 48, the National Weather Service said.

Motorists navigate an ice and snow-covered road in Mason City, Iowa.

It'll continue to produce heavy mountain snow and high winds across much of the western United States before tracking over the Rockies on Friday, according to the National Weather Service.

As it moves toward the East Coast, it could deliver ice Friday to the middle of the country, then mess up travel into the Monday commute, CNN meteorologist Gene Norman said.

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