John Stamos is staying in the Fox family.

Following the cancellation of his short-lived Fox comedy “Grandfathered,” the network has cast the “Full House” favorite as a series regular in the second season of “Scream Queens,” Variety has learned.

Stamos is a new addition to the A-list ensemble cast. Returning members from the original season are Jamie Lee Curtis, Emma Roberts, Lea Michele, Abigail Breslin, Keke Palmer, Billie Lourd, Niecy Nash and Glen Powell, who all will reprise their original characters.

“Scream Queens” season 2 — which returns on Tuesday, Sept. 20 — will be set in a hospital, after season 1 of the Ryan Murphy horror-anthology series was set in a sorority house. Putting the same characters in a new setting for the fresh episodes, the hospital will be run by Dean Cathy Munsch (Curtis), who has moved on after abolishing the college Greek system and traveled the world in search of a new mission. (For detailed season 2 character descriptions, click here.)

Stamos will play Dr. Brock Holt, the hospital’s brilliant, but secretive, head surgeon. More new cast members will be announced at a later date.

“Scream Queens” marks a reunion for Stamos and Murphy, following guest-starring spots in “Glee” and “The New Normal.” The horror-comedy hails from Murphy, Brad Falchuk and Ian Brennan.

Stamos’ short-lived “Grandfathered” struggled to find an audience this past TV season, but he was “get” for Fox who developed the 2015-2016 family sitcom as a vehicle particularly for the star.

Stamos is repped by WME.