President Trump said Thursday that the nation’s opioid epidemic — which is killing more than 100 people each day — is the “worst drug crisis in American history” and declared it a public health emergency, pledging the nation’s full resolve in overcoming it.

“Addressing it will require all of our effort, and it will require us to confront the crisis in all of its real complexity,” Trump said during a speech in the East Room of the White House, where he was joined by first lady Melania Trump and New Jersey Gov. Chris Christie (R), chairman of a presidential commission on combating the crisis.

“As Americans, we cannot allow this to continue,” Trump said. “It is time to liberate our communities from the scourge. We can be the generation that ends the opioid epidemic.”

With Trump’s declaration, the federal government will waive some regulations, give states more flexibility in how they use federal funds and expand the use of telemedicine treatment, according to senior administration officials who briefed reporters on Thursday morning.