After the war, scientists sought to put this knowledge to work in the clinic. Confident now that chemicals could combat cancer, Boston pediatrician Sidney Farber, who would come to be known as the father of modern chemotherapy, began conducting his own experiments on children with leukemia. He saw that folic acid encouraged the proliferation of disease in his patients. From this observation, Farber decided to administer doses of the opposite chemical, folate antagonists, to children under his care. To his delight, every single patient in his small study went into remission. Though none were permanently cured, the principle was established: Antifolates could be an important avenue for cancer-fighting drug development.

“They actually had some therapeutic responses,” Brawley says of Farber’s experiments. “No cures, but therapeutic responses. That led other folks to use some of the folate antagonists; in fact, one of the early folate antagonists was the one that was given to Ruth.”

The drug that Ruth took was called teropterin. Richard Lewisohn, a researcher at Mount Sinai Hospital in New York City, extracted the antifolates from brewer's yeast. The compound seemed to work in a few mice, but it had never been tried in humans. Against Lewisohn's will, the nascent drug was nonetheless made available for Ruth's use. "It went from mice to Babe Ruth," Bikhazi says with a sense of amazement, even after all these years. "There was no intermediary."

Miraculously, the drug worked. At least for a short time. Ruth started daily injections on June 29, 1947. In short order, Bikhazi reports, he gained back some of the weight he'd lost, reported less pain, and was finally able to swallow solid food. He continued chemotherapy for about six weeks and various radiation treatments for another year, as doctors cast about in search of a permanent cure. They never found one, and Ruth ultimately died of cancer on August 16, 1948, at the age of 53. But in the process of that trial and error treatment, Bikhazi reports, Ruth became perhaps the first patient to receive sequential radiation and chemotherapy. Now called "chemo-beamo," this two-pronged approach is standard treatment for many cancers today.

Bikhazi says the coordinated attack extended Ruth's lifespan significantly beyond the prognosis of the day. Perhaps most importantly for the Americans who so admired Ruth, the drug allowed him to live long enough to say goodbye to Yankee Stadium on June 13, 1948, just two months before his death. On that last visit to " the House that Ruth Built," he retired his No. 3 jersey and permanently sealed his No. 3 locker. Later, while leaning on his bat for support, Ruth received a standing ovation from the crowd.

For half a century, doctors believed that Ruth had cancer in his larynx, which grows from the voice box in the throat. The hoarse speech, as well as Ruth's prolific consumption of cigarettes and alcohol, supported this theory. But by evaluating Ruth's private autopsy reports, Bikhazi showed that Ruth actually had nasopharyngeal cancer, a rare illness that starts behind the nose. More than 70 years after his death, the distinction might seem minor, but the takeaway is staggering: Ruth, through sheer dumb luck, got almost exactly the right treatment. Laryngeal cancer typically requires radiation and surgery (including total removal of the voicebox), but nasopharyngeal cancer is still tackled with chemo-beamo today. "If Ruth had presented today with advanced-stage nasopharyngeal cancer as he had in 1946," Bikhazi wrote, "he would have had a favorable chance of long-term survival."

Bikhazi, who put the pieces of Babe's illness together in spite of damaged and even intentionally destroyed records, sees the story as an inherently uplifting one. At the very least, it's a reminder of how far cancer treatments have come. But that doesn't mean the tale is entirely rosy. "One of the problems in medicine is that there has always been this concept that people who are famous get treated special," Brawley says. "It's not a surprise to my mind that they threw thing after thing at him because he was Babe Ruth." While Ruth got the time he needed to say goodbye, no one else did, as experimental drugs like teropterin weren't made available to the masses and chemotherapy wasn't widely available until the 1950s.

More unnerving, perhaps, is the evidence that suggests Ruth was largely in the dark about his own illness. While it cannot be confirmed—his family says he didn’t know, but contemporaneous reports of his death clearly describe the cancer that killed him—Ruth’s potential ignorance of his own disease calls into question the ethics of his doctor’s decisions. Medical principles and the rules around clinical trials have evolved dramatically since Ruth’s time, and today no one would be allowed to undergo experimental treatment without being fully briefed on the risks they were taking on.

Still, Bikhazi says, Ruth’s contributions to medical history are bigger than any criticism. Thanks to patients like Ruth and scientists like Farber and Lewisohn, new chemotherapy drugs are more potent and more targeted than ever. The same is true of radiation. Instead of exposing an entire region of a patient’s body to a giant X-ray machine, hundreds of razor-thin beams can be trained onto a tumor to bypass most of the healthy issue as they attack the cancerous cells. “A shotgun approach is the old way of doing it,” Brawley says of Ruth’s era. “A sniper is the new way.”

Perhaps most significantly, the publicity Ruth's disease would eventually receive helped to eat away at the stigma cancer patients felt for centuries. Efforts in subsequent decades by other prominent cancer survivors, like First Lady Betty Ford, ushered in a world in which patients are informed and consulted about their disease and its treatment and, crucially, treated with dignity throughout the process.

After his death, Babe Ruth lay in state at Yankee Stadium, where fans lined up to pay their respects. Photographers on the scene captured tender moments as boys, young and old, cried over the Babe. The treatments at the time weren't capable of curing their hero, but the medical innovations Ruth shepherded along have gone on to cure countless others. One likes to assume Ruth would be selflessly proud of his contributions. After all, his most famous quote is equally applicable to baseball as it is to the fight against cancer: "Never let the fear of striking out get in your way."