In search of these qualities, we’ve developed—with the help of our data-crunching partners at Resonance Consultancy—this unique index of the 28 friendliest city neighborhoods in the United States. Whether embracing its immigrant roots (San Jose’s Japantown) or celebrating inclusion (Manhattan’s Hell’s Kitchen), an open-minded, open-hearted neighborhood can make travelers feel at home. This ultimate list offers starting points to explore American cities: enclaves full of places to delve into, people to meet, and enough bonhomie to make you want to return again and again. (See our list of best smaller U.S. cities.)