Enigma, Techies, Tide, and Kunkka will decide the outcome of late game fights to a much lesser degree. They are unlikely to be included in every lineup anymore, mostly because of the AoE nerfs.

(4) Troll strats will become very niche – the only individually strong Troll is now a Legendary, so you cannot assemble all four Trolls reliably until lvl9-10. This makes carrying the other three Trolls in your lineup extremely awkward.

Gimmicky, cookie-cutter early-game strats like Ench + Treant and (3) Scrappy (possibly with rerolls for upgrades) are weaker. You can still go for them, but it wouldn’t guarantee a good start. Treant, Clock, and Tinker won’t come into play until later because they are three-cost now.

(6) Hunter strats are much harder to get, which might make them too unreliable. Tide is not a Hunter, and Medusa is a 5-cost unit.

Mages seem a bit weaker in the mid game – Razor is a tier 1 unit with nerfed stats, and he was the backbone of Mages in the mid game. This, combined with the fact that Mages seem at a huge disadvantage against loot rounds, might make Mages a synergy you want to get only in the late game.