Forty-two players on the New England Patriots first three Super Bowl teams are part of a class-action lawsuit against the NFL and helmet maker Riddell alleging that they have symptoms of brain injuries caused by repetitive blows to the head during games and practices, according to a report.

In total, more than 340 former Patriots or their estates have sued the NFL and Riddell over brain injuries since the team was founded in 1960, including a number of Hall of Famers, the Boston Globe reported on Saturday.

In 2015, NFL teams agreed to pay about $1 billion to settle brain-injury claims by nearly 5,000 ex players in the suit – and an unknown number of Patriots are among more than 15,000 former players who have registered for potential benefits as part of the settlement, the report said.

Riddell was not part of the settlement and continues to challenge the lawsuit.

Using the team’s rosters, the Globe compiled a list of Patriots who alleged they suffered brain damage.

They include Hall of Famers Nick Buoniconti, Raymond Clayborn, Steve Grogan and Babe Parilli.

Eight players, including Junior Seau and Mosi Tatupu, were diagnosed after their deaths with CTE, Chronic Traumatic Encephalopathy, a degenerative brain disease caused by repetitive brain trauma.

Randall Gay, the youngest Patriot to play int he 2005 Super Bowl, retired in 2011 at 29 after suffering multiple concussions.

The 35-year-old Gay has graduated from law school and is a practicing attorney with his wife Desha, in Louisiana, but he said he has bouts of depression and other symptoms he believes were caused by football injuries.

“There are days when I just wake up and don’t want to be around anybody,’’ Gay told the Globe. “I just want to be in a room by myself, not doing anything, not even watching TV, and I can’t explain what’s going on.’’

Otis Smith, a defensive back who played on the team’s first Super Bowl victory in 2002, said mood swings are common among former Patriots players.

Smith, 52, who retired in 2003, said many of the injuries were probably caused before the NFL established concussion protocols.

“If you took a bad hit and got dizzy, they called it a stinger and gave you some smelling salts and you were back on the field again,’’ he said of the response to head injuries before 2000.

About $284 million so far has been distributed to about 250 players as part of the suit’s settlement.

And many more are waiting for funds to help them with treatment, the report said.