Christina Giuffre was last seen Wednesday in Croydon, Bristol Township.

A missing 21-year-old woman is believed “in danger,” Middletown police said Thursday.

Christina Giuffre, of the township's Forsythia Gate section in Levittown, was last seen driving a black Honda Civic on her way to work at about 3 p.m. Wednesday in Croydon, Bristol Township, according to a police Crimewatch post.

Police say she never showed for her shift.

“That's very uncharacteristic of her from all accounts,” detective Lt. Steve Forman said Thusday morning. He said investigators are “following up on all leads.”

Bucks County First Assistant District Attorney Gregg Shore said Thursday his office is also involved in the effort, adding that investigators have a “significant level of concern for her safety.”

Giuffre is described as 5 feet tall and 95 pounds, with green eyes and brown hair. Police say she was last seen wearing a red tank top and gray or white pants.

Anyone with information about where Giuffre might be is asked to call Middletown detective Aileen Torrente at 215-750-3845 ext. 2227, or to submit a tip through the Crimewatch site.