A Melbourne nightclub owner has accused Victoria Police of misrepresenting evidence of drug dealing at a city venue and then repeatedly blocking her attempts to obtain a video recording that led to several police raids.

Martha Tsamis will serve a defamation writ against Victoria Police this week, in a case that will involve some of the state's most senior officers in what she claims was a "vendetta" against her club, Inflation, in King Street.

Police video footage shows nothing amiss according to Inflation nightclub owner Martha Tsamis.

"Our complaint was investigated by other police members. They didn't even look at the video that purported to show drug dealing before issuing a statement saying that police had not done anything wrong. It was only when we got police into VCAT that they had to admit what had happened," Ms Tsamis told Fairfax Media.

In May 2013, undercover detectives entered Inflation and began filming with infrared cameras near the dance floor, which led to complaints by several patrons over an alleged breach of privacy.