Australian combat aircraft were not involved in an airstrike against Islamic State militants that allegedly killed at least dozens of civilians in the Iraqi city of Mosul, Defence Minister Marise Payne has said.

Senator Payne told Parliament on Monday afternoon that while such operations were complex, the best information the government had was that Australian Hornet or Superhornet planes did not take part in the strike.

According to international reports, at least two houses were destroyed around the time coalition forces struck Islamic State targets.

"Based on the information that is currently available to us, I'm advised that Australian strike aircraft were not involved in the airstrike in question," Senator Payne said. "As you will appreciate, it takes time to fully determine the details of a complex incident like this involving multiple aircraft from multiple nations.