Fans will be missing one distinctive voice on The Big Bang Theory.

E! News confirms that actress Carol Ann Susi died after a brief battle with an aggressive cancer. She was 62.

Susi played the role of Mrs. Wolowitz, Howard's mother, whose face was never shared with viewers, but whose voice would be recognizable from a mile away.

"The Big Bang Theory family has lost a beloved member today with the passing of Carol Ann Susi, who hilariously and memorably voiced the role of Mrs. Wolowitz," CBS and executive producers Chuck Lorre, Steven Molaro and Bill Prady said in a joint statement.

"Unseen by viewers, the Mrs. Wolowitz character became a bit of a mystery throughout the show's eight seasons. What was not a mystery, however, was Carol Ann's immense talent and comedic timing, which were on display during each unforgettable appearance. In addition to her talent, Carol Ann was a constant source of joy and kindness to all. Our thoughts and deepest condolences are with her family during this time, and we will miss her greatly."