Aluminum, although neurotoxic, is used in many pediatric vaccines as an adjuvant.

Abstract

Background Our group has shown that significant correlations exist between rates of Autism Spectrum Disorder (ASD) and total aluminum adjuvants given to children through vaccines in several Western countries. These correlations satisfied eight out of nine Hill criteria for causality. Experimental studies have demonstrated a range of behavioural abnormalities in young mice after postnatal exposure to aluminium. To build on our previous work, the current study will investigate the effect of aluminium adjuvants on social behaviour in mice. Anomalies in social interaction are a key characteristic of those with ASD.

Methods Neonatal CD-1 mice pups were injected with either a total of 550 μg of aluminum hydroxide gel (experimental group) or saline (control) spread out during the first two weeks of postnatal life. The mice were then subjected to behavioural tests for social interest and social novelty at postnatal week 8, 17 and 29. p-Values were calculated using the Mann-Whitney and Kruskal Wallis tests.

Results Aluminum injected mice showed diminished social interest compared to controls at week 8 (p = 0.016) and 17 (p = 0.012). They also demonstrated abnormal social novelty from controls at week 8 (p = 0.002) and week 29 (p = 0.042).