On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.

You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.





Show Anxiety Cannabidiol in Anxiety and Sleep: A Large Case Series. Shannon S, Lewis N, Lee H, Hughes S. 2019 Cannabidiol Open study CBD may be helpful in anxiety disorders according to a case series

Show Acute Pharmacokinetic Profile of Smoked and Vaporized Cannabis in Human Blood and Oral Fluid. Spindle TR. et al. 2019 Cannabis Controlled study Vaporisation may be more effective than smoking cannabis

Show Medical Cannabis Users' Comparisons between Medical Cannabis and Mainstream Medicine. Kruger DJ, Kruger JS. 2019 Cannabis Survey Many patients substitute their stunning medication by cannabis

Show Cannabinoid concentrations in confiscated cannabis samples and in whole blood and urine after smoking CBD-rich cannabis as a "tobacco substitute". Hädener M, Gelmi TJ, Martin-Fabritius M, Weinmann W, Pfäffli M. 2019 Cannabidiol Controlled study CBD-rich cannabis legally available in Switzerland may cause positive THC tests on blood and urine

Show Pain Impact of Medical Marijuana Legalization on Opioid Use, Chronic Opioid Use, and High-risk Opioid Use. Shah A, Hayes CJ, Lakkad M, Martin BC. 2019 Cannabis Survey The legalisation of medical cannabis in the USA is associated with lower opioid use

Show Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities. Barchel D, Stolar O, De-Haan T, Ziv-Baran T, Saban N, Fuchs DO, Koren G, Berkovitch M. 2019 Cannabis Open study Cannabis may be helpful in autism

Show Self-management strategies amongst Australian women with endometriosis: a national online survey. Armour M, Sinclair J, Chalmers KJ, Smith CA. 2019 Cannabis Survey Cannabis may be highly effective in the self-management of endometriosis according to survey

Show Pain Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis Purcell C.,Davis A., Moolman N.,Taylor S.N. 2019 Cannabis Open study Medical cannabis users reduce their intake of benzodiazepines

Show A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects. Solowij N, et al. 2019 Controlled study Low doses of CBD increased psychedelic effects of THC and high CBD doses reduced these effects

Show Medical cannabis patterns of use and substitution for opioids & other pharmaceutical drugs, alcohol, tobacco, and illicit substances; results from a cross-sectional survey of authorized patients. Lucas P, Baron EP, Jikomes N. 2019 Cannabis Survey Cannabis patients reduce the use of other medicinal drugs and alcohol

Show Recreational marijuana legalization and prescription opioids received by Medicaid enrollees. Shi Y, Liang D, Bao Y, An R, Wallace MS, Grant I. 2019 Open study Legalisation of cannabis for adult use is associated with reduced opioid use in the USA

Show Pain Pills to pot: observational analyses of cannabis substitution among medical cannabis users with chronic pain. Boehnke KF, Scott JR, Litinas E, Sisley S, Williams DA, Clauw DJ. 2019 Cannabis Open study Cannabis may be an effective pain reliever and substitute for opioids according to a survey

Show Cancer Cannabis Impacts Tumor Response Rate to Nivolumab in Patients with Advanced Malignancies. Taha T, Meiri D, Talhamy S, Wollner M, Peer A, Bar-Sela G. 2019 Cannabis Open study Cannabis may have negative effects on cancer therapy if given together with immunotherapy

Show On the impact of cannabis consumption on traffic safety: a driving simulator study with habitual cannabis consumers. Tank A, Tietz T, Daldrup T, Schwender H, Hellen F, Ritz-Timme S, Hartung B. 2019 Cannabis Open study In driving simulator tests 3 hours after cannabis consumption there were no longer significant faults.

Show Pain Qualifying Conditions Of Medical Cannabis License Holders In The United States. Boehnke KF, Gangopadhyay S, Clauw DJ, Haffajee RL. 2019 Cannabis Open study Chronic pain is the main reason for the medical use of cannabis in the USA

Show Anxiety Cannabis use behaviors and prevalence of anxiety and depressive symptoms in a cohort of Canadian medicinal cannabis users. Turna J, Simpson W, Patterson B, Lucas P, Van Ameringen M. 2019 Cannabis Survey Cannabis may be helpful in anxiety disorders according to large survey

Show Marijuana smoking and markers of testicular function among men from a fertility centre Nassan FL, et al. 2019 Cannabis Open study Cannabis use was associated with higher sperm concentration

Show Cancer Dronabinol for the Treatment of Paraneoplastic Night Sweats in Cancer Patients: A Report of Five Cases. Carr C, Vertelney H, Fronk J, Trieu S. 2019 Delta-9-THC Uncontrolled case report THC may reduce night sweats in cancer patients

Show Cancer The Prevalence of Nonprescription Cannabinoid-Based Medicines in British Children's Hospices: Results of a National Survey. Tatterton MJ, Walker C. 2019 Cannabis Survey Many families use cannabis oil for their children in British hospices

Show Epilepsy Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study. Thiele E, et al. 2019 Cannabidiol CBD showed long-term efficacy in the treatment of epilepsy due to Lenox-Gastaut syndrome

Show Psychosis/schizophrenia Effect of cannabis on weight and metabolism in first-episode non-affective psychosis: Results from a three-year longitudinal study. Vázquez-Bourgon J, et al. 2019 Cannabis Open study Cannabis use may produce a protective effect against weight gain in psychosis

Show Cancer Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol. Dall'Stella PB, Docema MFL, Maldaun MVC, Feher O, Lancellotti CLP. 2019 Cannabidiol Uncontrolled case report CBD may increase the effects of chemotherapy and radiation in glioblastoma according to case reports

Show Lower circulating endocannabinoid levels in children with autism spectrum disorder. Aran A, et al. 2019 Open study Children with autism have lower blood levels of endocannabinoids

Show Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder. Pretzsch CM, et al. 2019 Cannabidiol Controlled study No hint of efficacy of CBD in autism

Show A quasi-experimental evaluation of marijuana policies and youth marijuana use Coley RL. et al. 2019 Cannabis Open study Young people may use less cannabis in the US states with medical cannabis laws

Show The Association between Cannabis Product Characteristics and Symptom Relief. Stith SS, Vigil JM, Brockelman F, Keeling K, Hall B. 2019 Cannabis Open study Medicinal effects of cannabis are mainly based on THC and cannabis flowers were most effective

Show Spontaneous, anecdotal, retrospective, open-label study on the efficacy, safety and tolerability of cannabis galenical preparation (Bedrocan). Palmieri B, Laurino C, Vadalà M. 2019 Cannabis Open study An oral preparation of Bedrocan cannabis showed significant improvement in several chronic diseases

Show Cancer Striking lung cancer response to self-administration of cannabidiol: A case report and literature review. Sulé-Suso J, Watson NA, van Pittius DG, Jegannathen A. 2019 Cannabidiol Uncontrolled case report CBD and a strong effect on a patient with lung cancer

Show Gastrointestinal disorder Cannabis Oil Use by Adolescents and Young Adults With Inflammatory Bowel Disease. Hoffenberg EJ, McWilliams S, Mikulich-Gilbertson S, Murphy B, Hoffenberg A, Hopfer CJ. 2019 Cannabis Open study Many young patients with irritable bowel syndrome use cannabis to treat symptoms

Show Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers. Thayer RE, YorkWilliams SL, Hutchison KE, Bryan AD. 2019 Cannabis Open study Cannabis use has no relevant effect on the brain on adults

Show Depression Marijuana use and major depressive disorder are additively associated with reduced verbal learning and altered cortical thickness. Radoman M, Hoeppner SS, Schuster RM, Evins AE, Gilman JM. 2019 Cannabis Open study Cannabis may have negative effects on young people with depression

Show Asthma A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults. Bramness JG, von Soest T. 2019 Cannabis Survey Smoking of cannabis may be a risk factor for asthma

Show Gastrointestinal disorder Higher odds of irritable bowel syndrome among hospitalized patients using cannabis: a propensity-matched analysis. Adejumo AC, Ajayi TO, Adegbala OM, Bukong TN. 2019 Cannabis Survey Patients with irritable bowel syndrome are more likely to use cannabis

Show Cancer Relationship of Cannabis Use to Patient-Reported Symptoms in Cancer Patients Seeking Supportive/Palliative Care. Donovan KA, et al. 2019 Cannabis Open study Many cancer patients treated themselves with cannabis

Show Gastrointestinal disorder Cannabinoid Use in Patients With Gastroparesis and Related Disorders: Prevalence and Benefit. Jehangir A, Parkman HP. 2019 Cannabis Survey Cannabis may be an effective treatment of delayed gastric emptying according to a survey

Show Cancer Impact of Medical Cannabis on Patient-Reported Symptoms for Patients With Cancer Enrolled in Minnesota's Medical Cannabis Program. Anderson SP, Zylla DM, McGriff DM, Arneson TJ. 2019 Cannabis Open study Cancer patients report symptom relief by cannabis

Show Gastrointestinal disorder Association Between Cannabis Use and Complications Related to Crohn's Disease: A Retrospective Cohort Study. Mbachi C, et al. 2019 Cannabis Open study Cannabis may reduce complications of Crohn’s disease

Show Illicit drug use and prescription drug misuse among young adult medical cannabis patients and non-patient users in Los Angeles. Fedorova EV, et al. 2019 Cannabis Open study The medical use of cannabis was associated with lower probability of illegal drug use in the USA

Show Gastrointestinal disorder Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer. Grill M, et al. 2019 Other cannabinoids Open study The endocannabinoid system is altered in patients with irritable bowel syndrome and bowel cancer

Show Depression Does morning affect contribute to daily Cannabis use? Testa M, Wang W, Derrick JL, Brown WC, Collins RL. 2019 Cannabis Open study Cannabis use increases positive affect and reduces anxiety

Show Employment and Marijuana Use Among Washington State Adolescents Before and After Legalization of Retail Marijuana. Graves JM, Whitehill JM, Miller ME, Brooks-Russell A, Richardson SM, Dilley JA. 2019 Cannabis Survey Cannabis use in adolescents decreased in Washington State after legalisation

Show Depression Trends of major depressive episode among people with cannabis use: Findings from the National Survey on Drug Use and Health 2006-2015. Carrà G, Bartoli F, Crocamo C. 2019 Cannabis Survey Heavy cannabis use is more likely associated with depression

Show Gastrointestinal disorder;Psychosis/schizophrenia Cannabis use disorders may protect against certain disorders of the digestive organs in people with schizophrenia but not in healthy controls. Olesen JA, Posselt CM, Poulsen CH, Nordentoft M, Hjorthøj C. 2019 Cannabis Survey Cannabis use in patients with schizophrenia is associated with a reduced risk for inflammatory bowel disease

Show Psychosis/schizophrenia The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study. Di Forti M, et al. 2019 Cannabis Open study High potency cannabis is associated with a higher risk for psychosis

Show Prescription of a THC/CBD-Based Medication to Patients with Dementia: A Pilot Study in Geneva Broers B., Patà Z., Mina A., Wampfler J., de Saussure C., Pautex S. 2019 Cannabis Open study Cannabis may improve behaviour in patients with dementia according to observational study

Show Multiple sclerosis Multiple Sclerosis and Use of Medical Cannabis: A Retrospective Review Evaluating Symptom Outcomes McCormack K. et al. 2019 Cannabis Open study MS patients taking cannabis were able to reduce intake of opioids and benzodiazepines

Show Posttraumatic stress disorder Loss of exercise- and stress-induced increases in circulating 2-arachidonoylglycerol concentrations in adults with chronic PTSD. Crombie KM, Leitzelar BN, Brellenthin AG, Hillard CJ, Koltyn KF. 2019 Other cannabinoids Controlled study The endocannabinoid system shows a reduced activity in patients with post-traumatic stress disorder

Show Depression Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder. Meyer JD, Crombie KM, Cook DB, Hillard CJ, Koltyn KF. 2019 Controlled study Endocannabinoids contribute to the mood improving effects of exercise in patients with major depression

Show Dependency/withdrawal The relationship between motivations for cannabis consumption and problematic use. Casajuana Kögel C, López-Pelayo H, Oliveras C, Colom J, Gual A, Balcells-Oliveró MM. 2019 Cannabis Open study The risk for problematic use of cannabis depends on reason for use

Show Gastrointestinal disorder Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Couch DG, Cook H, Ortori C, Barrett D, Lund JN, O'Sullivan SE. 2019 Cannabidiol Controlled study CBD and palmitoylethanolamine may be helpful in inflammatory bowel disease

Show Epilepsy Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic Cannabidiol in Pediatric Patients with Treatment-Resistant Epilepsy. Wheless JW, et al. 2019 Cannabidiol Controlled study CBD may influence the blood concentrations of antiepileptic drugs

Show Epilepsy Higher cannabidiol plasma levels are associated with better seizure response following treatment with a pharmaceutical grade cannabidiol. Szaflarski JP, Hernando K, Bebin EM, Gaston TE, Grayson LE, Ampah SB, Moreadith R. 2019 Cannabidiol Open study Efficacy of CBD in epilepsy is correlated to blood levels

Show Dependency/withdrawal Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial. Hurd YL, Spriggs S, Alishayev J, Winkel G, Gurgov K, Kudrich C, Oprescu AM, Salsitz E. 2019 Cannabidiol Controlled study CBD reduces craving in drug-abstinence individuals with heroin dependency according to clinical study

Show Medical marijuana laws are associated with increases in substance use treatment admissions by pregnant women. Meinhofer A, Witman A, Murphy S, Bao Y. 2019 Cannabis Open study Legalisation of cannabis for medical use in the US increased cannabis use by pregnant women

Show Cannabis use as a risk factor for causing motor vehicle crashes: a prospective study. Brubacher JR. et al. 2019 Cannabis Open study Non-significant increase of crash risk in drivers under the influence of cannabis

Show Cancer Medical Cannabis Use in Glioma Patients Treated at a Comprehensive Cancer Center in Florida. Reblin M, Sahebjam S, Peeri NC, Martinez YC, Thompson Z, Egan KM. 2019 Cannabis Open study Many patients with brain cancer use cannabis

Show Lifetime marijuana use in relation to insulin resistance in lean, overweight and obese U.S. adults Ngueta G, Ndjaboue R. 2019 Open study Cannabis may have a protective effects against diabetes in obese individuals

Show The association between cannabis use and psychiatric comorbidity in people with personality disorders: A population-based longitudinal study. Shalit N, Rehm J, Lev-Ran S. 2019 Open study Cannabis users with personality disorders are not at increased risk for developing other psychiatric disorders

Show The influence of substance use on the effectiveness of antipsychotic medication: a prospective, pragmatic study. Alisauskiene R, Løberg EM, Gjestad R, Kroken RA, Jørgensen HA, Johnsen E. 2019 Open study Cannabis had no influence on the efficacy of antipsychotic medication

Show Pain Medical Cannabis: Effects on Opioid and Benzodiazepine Requirements for Pain Control. O'Connell M, Sandgren M, Frantzen L, Bower E, Erickson B. 2019 Open study Cannabis reduces opioid use by pain patients

Show Epilepsy Cannabis Use Disorder and Epilepsy: A Cross-National Analysis of 657 072 Hospitalized Patients Patel RS, Mekala HM, Tankersley WE. 2019 Cannabis Open study The use of cannabis, tobacco and alcohol is associated with higher prevalence of epilepsy

Show Depression Depression and marijuana use disorder symptoms among current marijuana users Dierker L, Selya A, Lanza S, Li R3, Rose J 2018 Cannabis Survey People with depression more often use cannabis

Show Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis Karoly HC, Bidwell LC, Mueller RL, Hutchison KE 2018 Cannabis Open study Cannabinoid compounds may serve to mitigate inflammation associated with alcohol use

Show Pain Patient Perceptions of the Use of Medical Marijuana in the Treatment of Pain After Musculoskeletal Trauma: A Survey of Patients at 2 Trauma Centers in Massachusetts. Heng M, McTague MF, Lucas RC, Harris MB, Vrahas MS, Weaver MJ 2018 Cannabis Survey Patients believe that medical marijuana is a valid treatment and that it does have a role in reducing postinjury and postoperative pain.

Show Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease. Adejumo AC, Ajayi TO, Adegbala OM, Adejumo KL, Alliu S, Akinjero AM, Onyeakusi NE, Ojelabi O, Bukong TN 2018 Cannabis Open study Cannabis use may be associated with a reduced incidence of liver disease in alcoholics

Show HIV/AIDS;Pain Cannabis Use is Associated with Lower Odds of Prescription Opioid Analgesic Use Among HIV-Infected Individuals with Chronic Pain Sohler NL, Starrels JL, Khalid L, Bachhuber MA, Arnsten JH, Nahvi S, Jost J, Cunningham CO 2018 Cannabis Open study Medical cannabis legislation might reduce the need for opioid analgesics for pain management

Show A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers Kiertscher SM, Gangalum PR, Ibrahim G, Tashkin DP, Roth MD 2018 Cannabis Open study

Show Marijuana Use and Renal Function Among US Adults Lu C, Papatheodorou SI, Danziger J, Mittleman MA 2018 Cannabis Open study

Show Cannabidiol Based Medical Cannabis in Children with Autism- a Retrospective Feasibility Study Aran A., Cassuto H., Lubotzky A. 2018 Cannabis;Cannabidiol Open study A CBD-rich cannabis extract may be effective in children with autism

Show Dependency/withdrawal Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal Hindocha C. et al. 2018 Cannabidiol Controlled study CBD may be helpful in tobacco dependency

Show Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study Morris, Madeline A. et al. 2018 Cannabis Open study Cannabis use is not associated with increased risks of respiratory diseases.

Show Marijuana use and fecundability in a North American preconception cohort study Wise LA1, Wesselink AK, Hatch EE, Rothman KJ, Mikkelsen EM, Sørensen HT, Mahalingaiah S 2018 Cannabis Open study

Show Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes van Eyk HJ et al. 2018 Open study Caloric restriction in patients with type 2 diabetes reduces endocannabinoid levels

Show The Grass Might Be Greener: Medical Marijuana Patients Exhibit Altered Brain Activity and Improved Executive Function after 3 Months of Treatment Gruber SA, Sagar KA, Dahlgren MK, Gonenc A, Smith RT, Lambros AM, Cabrera KB, Lukas SE 2018 Cannabis Open study The medical use of cannabis improves cognitive performance

Show Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly Abuhasira R, Schleider LB, Mechoulam R, Novack V 2018 Cannabis Open study The medical use of cannabis is safe in elder people

Show Rare diseases Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial Thiele EA. et al. 2018 Cannabidiol Controlled study CBD is effective against seizures in Lennox-Gastaut syndrome

Show HIV/AIDS Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals Manuzak JA et al. 2018 Cannabis Open study Heavy cannabis use in patients with HIV is associated with improved immune function

Show Cancer Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer Bar-Lev Schleider L et al. 2018 Cannabis Open study Cannabis is effective in alleviating symptoms of cancer patients

Show Pain Medical Cannabis for the Treatment of Fibromyalgia Habib G, Artul S. 2018 Cannabis Open study Cannabis may have a beneficial effect on patients with fibromyalgia

Show Pain Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability Cooper ZD, Bedi G, Ramesh D, Balter R, Comer SD, Haney M 2018 Cannabis Open study Cannabis enhances the pain reducing effects of the opioid oxycodone according to experimental study

Show Epilepsy Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia 2018 Cannabidiol Open study About half of children with epilepsy had a significant improvement following CBD treatment

Show Spinal cord injury Cannabis Use in Individuals With Spinal Cord Injury or Moderate to Severe Traumatic Brain Injury in Colorado Hawley LA, Ketchum JM, Morey C, Collins K, Charlifue S 2018 Cannabis Survey A high number of patients with spinal cord injury and traumatic brain injury use cannabis

Show Rare diseases Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome Devinsky O. et al. 2018 Cannabidiol Controlled study The use of CBD in children has only minimal effects on other antiepileptic drugs

Show Beneficial Effect of Medical Cannabis in the Treatment of a Pharmacoresistant Nausea Associated with a Somatoform Disorder in a Patient with Post-Polio Syndrome Bleckwenn M, Weckbecker K, Voss S 2018 Cannabis Uncontrolled case report Cannabis improved nausea in a patient with post-polio syndrome

Show Marijuana use and mortality following orthopedic surgical procedures. Moon AS, Smith W, Mullen S, Ponce BA, McGwin G, Shah A, Naranje SM 2018 Cannabis Open study Cannabis use was associated with reduced mortality following orthopaedic surgery

Show Appetite loss/weight loss;Cancer The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial Turcott JG, Del Rocío Guillen Núñez M, Flores-Estrada D, Oñate-Ocaña LF, Zatarain-Barrón ZL, Barrón F, Arrieta O 2018 Nabilone Controlled study Nabilone improved appetite in cancer patients in a controlled clinical study

Show Pain Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay Cuñetti L, Manzo L, Peyraube R, Arnaiz J, Curi L, Orihuela S 2018 Cannabidiol Open study CBD may reduce pain in patients with kidney transplants

Show Huntington's disease Cannabinoids for Treatment of Dystonia in Huntington's Disease Saft C, von Hein SM, Lücke T, Thiels C, Peball M, Djamshidian A, Heim B3, Seppi K 2018 Other cannabinoids Open study Cannabinoids may be helpful in the treatment of Huntington's disease

Show Plasma anandamide concentrations are lower in children with autism spectrum disorder Karhson DS et al. 2018 Open study In patients with autism there are low blood concentrations of anandamide

Show Effect of cannabis and tobacco on emphysema in patients with spontaneous pneumothorax Ruppert AM et al. 2018 Cannabis Controlled study;Open study Cannabis use may accelerate the development of emphysema in tobacco smokers

Show Pain Association of Medical and Adult-Use Marijuana Laws With Opioid Prescribing for Medicaid Enrollees Wen H, Hockenberry JM 2018 Cannabis Open study Legalization of cannabis for medical use is associated with reduced prescriptions of opioids

Show Pain Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population Bradford AC, Bradford WD, Abraham A, Bagwell Adams G 2018 Cannabis Open study Legalization of cannabis for medical use is associated with reduced prescriptions of opioids

Show A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis Irving PM et al. 2018 Cannabidiol Controlled study A CBD-rich cannabis extract improved symptoms of ulcerative colitis in a controlled clinical study

Show A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis Irving PM et al. 2018 Cannabidiol Controlled study A CBD-rich cannabis extract improved symptoms of ulcerative colitis in a controlled clinical study

Show Psychosis/schizophrenia The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial Boggs DL et al. 2018 Cannabidiol Controlled study CBD did not improve cognition in patients with schizophrenia

Show Anxiety;Pain;Sleep disorder Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep Piper BJ et al. 2018 Cannabis Survey Patients who use cannabis reduce their use in medications for pain, anxiety, migraine and sleep disorders

Show Pain Effects of Legal Access to Cannabis on Scheduled II-V Drug Prescriptions. Stith SS, Vigil JM, Adams IM, Reeve AP 2018 Cannabis Open study Legal access to cannabis may reduce the treatment with other medicinal drugs

Show Cancer;Pain Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain Lichtman AH et al. 2018 Other cannabinoids Low effects of a cannabis extract in cancer patients in a large controlled study

Show Multiple sclerosis THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study Maniscalco GT et al. 2018 Other cannabinoids Open study Cannabis may be beneficial in overactive bladder of patients with MS according to an observational study

Show HIV/AIDS Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients Nordmann S et al. 2018 Cannabis Open study Daily cannabis use may protect the liver in people with HIV and hepatitis C

Show HIV/AIDS Association of Cannabis, Stimulant, and Alcohol use with Mortality Prognosis Among HIV-Infected Men Adams, Joëlla W. et al. 2018 Cannabis Survey Cannabis use has no effect on the mortality of HIV-infected men

Show Pain Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy Nugent SM et al. 2018 Cannabis Survey Cannabis use in pain patients was associated with a higher risk for opioid misuse

Show HIV/AIDS HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients Rizzo MD et al. 2018 Cannabis Controlled study Cannabis may slow inflammation of the brain in patients with HIV and may maintain cognitive performance

Show Psychosis/schizophrenia Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial McGuire P et al. 2018 Cannabidiol Controlled study Cannabidiol may be helpful in schizophrenia according to clinical study

Show Sleep disorder Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea Carley DW et al. 2018 Other cannabinoids Controlled study THC may be effective in the treatment of sleep apnoea according to a clinical study

Show Marijuana Use is Protective in Burns Williams F, Chrisco L, Nizamani R, Cairns B, Jones S 2018 Cannabis Survey Cannabis use reduces mortality in patients with burns

Show Epilepsy Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents - An observational, longitudinal study Hausman-Kedem M, Menascu S, Kramer U 2018 Cannabis Open study A cannabis extract with THC and CBD reduced seizures in epilepsy

Show Anxiety;Depression A naturalistic examination of the perceived effects of cannabis on negative affect Cuttler C, Spradlin A, McLaughlin RJ 2018 Cannabis Open study Acute use of cannabis may reduce anxiety and depression

Show No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study Linares IMP et al. 2018 Cannabidiol Controlled study CBD may be used against anxiety and depression without altering normal sleep

Show Relation of Cannabis Use and Atrial Fibrillation Among Patients Hospitalized for Heart Failure Adegbala O et al. 2018 Cannabis Open study Cannabis use was associated with a lower risk of artrial fibrillation

Show Dependency/withdrawal The effect of high-dose dronabinol (oral THC) maintenance on cannabis self-administration Schlienz NJ, Lee DC, Stitzer ML, Vandrey R 2018 Delta-9-THC Controlled study High doses of oral THC reduced intake of inhaled THC

Show Testing associations between cannabis use and subcortical volumes in two large population-based samples Gillespie NA et al. 2018 Open study Cannabis use has no effect on brain structure

Show Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users Beale C et al. 2018 Cannabis Open study CBD repaired negative effects of regular cannabis use on a certain brain region

Show Endocannabinoid system in systemic lupus erythematosus: First evidence for a deranged 2-arachidonoylglycerol metabolism Navarini L et al. 2018 Other cannabinoids Open study Systemic lupus erythematosus was associated with an altered endocannabinoid system

Show Pain Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects van Amerongen G, Siebenga P, de Kam ML, Hay JL, Groeneveld GJ 2018 Delta-9-THC Open study Acute pain is reduced by THC

Show Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis Scott JC et al. 2018 Cannabis Effects of cannabis on cognitive performance in adolescents are small

Show Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome Devinsky O. et al. 2018 Cannabidiol Controlled study

Show Dependency/withdrawal The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers. Hindocha C, Freeman TP, Grabski M, Crudgington H, Davies AC, Stroud JB, Das RK, Lawn W, Morgan CJA, Curran HV. 2018 Cannabidiol Controlled study

Show Pain Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. Baron EP, Lucas P, Eades J, Hogue O 2018 Cannabis Open study Pain patients often substitute opioids with cannabis

Show Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. Khalaj M. et al. 2018 Other cannabinoids Controlled study

Show Multiple sclerosis Sativex® as Add-on therapy Vs. further optimized first-line ANTispastics (SAVANT) in resistant multiple sclerosis spasticity: a double-blind, placebo-controlled randomised clinical trial. Markovà J, Essner U, Akmaz B, Marinelli M, Trompke C, Lentschat A, Silván CV 2018 Other cannabinoids Controlled study Long-term efficacy of a cannabis spray in the treatment of spasticity due to multiple sclerosis

Show Multiple sclerosis Effect of tetrahydrocannabinol:cannabidiol oromucosal spray on activities of daily living in multiple sclerosis patients with resistant spasticity: a retrospective, observational study. Mallada Frechín J. 2018 Other cannabinoids Survey A cannabis spray has positive effects on activities of daily living in patients with Multiple Sclerosis

Show Pain The relationship of endocannabinoidome lipid mediators with pain and psychological stress in women with fibromyalgia - a case control study Stensson N, Ghafouri N, Ernberg M, Mannerkorpi K, Kosek E, Gerdle B, Ghafouri B 2018 Other cannabinoids Controlled study Fibromyalgia is associated with increased blood levels of endocannabinoids

Show Psychosis/schizophrenia The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences Naji L. et al. 2018 Cannabis Open study Cannabis use has no effect on suicidal attempts in psychiatric disorders

Show Self-initiated use of topical cannabidiol oil for epidermolysis bullosa Chelliah MP, Zinn Z, Khuu P, Teng JMC 2018 Cannabidiol

Show Endocannabinoid receptor CB2R is significantly expressed in aspirin-exacerbated respiratory disease: a pilot study Corrado A, Battle M, Wise SK, Lee FE, Guidot DM, DelGaudio JM, Molina SA, Levy JM 2018 Other cannabinoids Controlled study The number of CB2 receptors is increased in a certain respiratory disease

Show Multiple sclerosis;Pain Pain Modulation after Oromucosal Cannabinoid Spray (SATIVEX®) in Patients with Multiple Sclerosis: A Study with Quantitative Sensory Testing and Laser-Evoked Potentials. Turri M, Teatini F, Donato F, Zanette G, Tugnoli V, Deotto L, Bonetti B, Squintani G 2018 Other cannabinoids Open study Cannabis reduces pain in multiple sclerosis

Show Pain Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis. Bellnier T, Brown GW, Ortega TR. 2018 Cannabis Open study Cannabis reduces pain and increases the quality of life in pain patients

Show Cancer Many cancer patients use cannabis in Canada Martell K, Fairchild A, LeGerrier B, Sinha R, Baker S, Liu H, Ghose A, Olivotto IA, Kerba M. 2018 Cannabis Survey Many cancer patients use cannabis in Canada

Show Posttraumatic stress disorder Cannabis Use Disorder and Post-Deployment Suicide Attempts in Iraq/Afghanistan-Era Veterans Adkisson K, Cunningham KC, Dedert EA, Dennis MF, Calhoun PS, Elbogen EB, Beckham JC, Kimbrel NA. 2018 Cannabis Survey Cannabis dependence was associated with an increased risk of suicide in war veterans

Show Pain Medical Cannabis Legalization and Opioid Prescriptions: Evidence on US Medicaid Enrollees during 1993-2014. Liang D, Bao Y, Wallace M, Grant I, Shi Y. 2018 Cannabis Open study Legalization of cannabis for medical use in the US is associated with reduced opioid prescriptions

Show Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction Johnson-Sasso CP, Tompkins C, Kao DP, Walker LA. 2018 Cannabis Open study Cannabis use is associated with decreased mortality in hospital after a heart attack

Show Epilepsy Open-label use of Highly* purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes. Devinsky O, et al. 2018 Cannabidiol Open study CBD reduces seizures in several further childhood-onset epilepsy forms according to an open-label study

Show Multiple sclerosis Tetrahydrocannabinol/Cannabidiol Oromucosal Spray in Patients With Multiple Sclerosis: A Pilot Study on the Plasma Concentration-Effect Relationship. Contin M, Mancinelli L, Perrone A, Sabattini L, Mohamed S, Scandellari C, Foschi M, Vacchiano V, Lugaresi A, Riva R. 2018 Delta-9-THC;Cannabidiol Open study Large variation of plasma concentrations of THC and CBD after oral intake

Show Epilepsy Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results. Szaflarski JP, et al. 2018 Cannabidiol Open study CBD was effective in several epilepsy forms in the long-term

Show Sleep disorder Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions. Vigil JM, Stith SS, Diviant JP, Brockelman F, Keeling K, Hall B. 2018 Cannabis Open study The effect of cannabis on insomnia depended on the cannabis variety

Show Pain Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study. Campbell G. et al. 2018 Cannabis Open study Pain patients who use cannabis have greater pain severity than non-users

Show Marijuana Use in Adults Living with Sickle Cell Disease. Roberts JD, Spodick J, Cole J, Bozzo J, Curtis S, Forray A. 2018 Cannabis Survey Cannabis may have therapeutic effects in patients with sickle cell disease

Show Anxiety;Depression;Pain;Sleep disorder A Cross-Sectional Study of Cannabidiol Users. Corroon J, Phillips JA. 2018 Cannabidiol Survey CBD is mostly used against pain, sleep disorders, anxiety and depression

Show Pain Marijuana's Influence on Pain Scores, Initial Weight Loss, and Other Bariatric Surgical Outcomes. Bauer FL, Donahoo WT, Hollis HW Jr, Tsai AG, Pottorf BJ, Johnson JM, Silveira LJ, Husain FA. 2018 Cannabis Open study Cannabis users need higher doses of opioids after surgery

Show Alzheimer's disease Treating non-cognitive symptoms of people with dementia Science Daily 2018 Delta-9-THC Controlled study Nabilone improves agitation and other behavioural symptoms in patients with Alzheimer’s disease

Show Epilepsy Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community Suraev A. et al. 2018 Cannabis Survey THC and CBD content in products used for self-treatment of Australian children with epilepsy varies considerably

Show Tourette's syndrome Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report. Pichler EM, Kawohl W, Seifritz E, Roser P. 2018 Delta-9-THC;Cannabidiol Uncontrolled case report A case report suggests that CBD may be beneficial in Tourette syndrome

Show Long-Term Heavy Recreational Cannabis Use and Serum Delta-9-Tetrahydrocannabinol Levels are not Associated with an Impaired Liver Function in Cannabis Dependents. Bonnet U, Canbay A, Specka M, Scherbaum N. 2018 Cannabis Open study Heavy cannabis use has no relevant influence on liver function

Show Cancer chemotherapy Safety and efficacy of nabilone for acute chemotherapy-induced vomiting prophylaxis in pediatric patients: A multicenter, retrospective review. Polito S, MacDonald T, Romanick M, Jupp J, Wiernikowski J, Vennettilli A, Khanna M, Patel P, Ning W, Sung L, Dupuis LL. 2018 Delta-9-THC Open study Nabilone is well tolerated in children undergoing chemotherapy

Show Medical marijuana laws and workplace fatalities in the United States. Anderson DM, Rees DI, Tekin E. 2018 Cannabis Open study Medical cannabis laws in the USA are associated with improved workplace safety

Show Dependency/withdrawal Falling rates of marijuana dependence among heavy users. Davenport S. 2018 Cannabis Open study The risk of dependence formation among heavy cannabis users in the USA declined in the past 15 years

Show Epilepsy Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study. Szaflarski JP, Bebin EM, Cutter G, DeWolfe J, Dure LS, Gaston TE, Kankirawatana P, Liu Y, Singh R, Standaert DG, Thomas AE, Ver Hoef LW; UAB CBD Program. 2018 Cannabidiol Open study Large study with CBD in patients with epilepsy demonstrates good long-term safety of the medication

Show Cancer Current natural therapies in the treatment against glioblastoma. Erices JI, Torres Á, Niechi I, Bernales I, Quezada C. 2018 Cannabis Cannabinoids may be helpful in glioblastoma

Show Epilepsy Cannabidiol for treating drug-resistant epilepsy in children: the New South Wales experience. Chen KA, Farrar M, Cardamone M, Gill D, Smith R, Cowell CT, Truong L, Lawson JA. 2018 Cannabidiol Open study CBD effective in children with epilepsy

Show Medicinal cannabis in Australia, 2016: the Cannabis as Medicine Survey (CAMS-16). Lintzeris N, Driels J, Elias N, Arnold JC, McGregor IS, Allsop DJ. 2018 Cannabis Survey Results of a survey among Australian patients, who treat themselves with cannabis

Show Pain Self-Reported Effectiveness and Safety of Trokie® Lozenges: A Standardized Formulation for the Buccal Delivery of Cannabis Extracts. Crowley K, de Vries ST, Moreno-Sanz G. 2018 Cannabis Open study Cannabis lozenges reduce pain in an observational study

Show Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography. Hirvonen J, et al. 2018 Open study Tobacco smokers have reduced concentrations of brain CB1 receptors

Show The Association Between Tetrahydrocannabinol and Lower Urinary Tract Symptoms Utilizing the National Health and Nutrition Examination Survey. Fantus RJ, Riedinger CB, Chang C, Helfand BT. 2018 Delta-9-THC Survey Cannabis use is protective against lower urinary tract symptoms

Show Pain The Consumption of Cannabis by Fibromyalgia Patients in Israel. Habib G, Avisar I. 2018 Cannabis Survey Many patients with fibromyalgia profit from a treatment with cannabis according to survey

Show Psychosis/schizophrenia Impact of substance use disorder on gray matter volume in schizophrenia. Quinn M, McHugo M, Armstrong K, Woodward N, Blackford J, Heckers S. 2018 Cannabis Controlled study Cannabis use does not influence gray matter of the brain in schizophrenia

Show Psychosis/schizophrenia GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Pasman JA, et al. 2018 Cannabis Open study Genetic investigation shows positive influence of schizophrenia risk on cannabis use

Show Cannabinoid concentrations in blood and urine after smoking cannabidiol joints. Meier U, Dussy F, Scheurer E, Mercer-Chalmers-Bender K, Hangartner S. 2018 Cannabidiol Uncontrolled case report CBD blood concentrations after smoking CBD cigarettes

Show Pain Medina SH, Nadarajah V, Jauregui JJ, Smuda MP, Foster M, Meredith SJ, Packer JD, Henn RF 3rd. 2018 Cannabis Open study Cannabis use was associated with less pain after orthopaedic surgery

Show Pain Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity. Weizman L, Dayan L, Brill S, Nahman-Averbuch H, Hendler T, Jacob G, Sharon H. 2018 Delta-9-THC Controlled study THC reduces neuropathic pain and this is associated with altered connections between two brain regions

Show Patient-Reported Symptom Relief Following Medical Cannabis Consumption Stith SS, Vigil JM, Brockelman F, Keeling K, Hall B. 2018 Cannabis Open study Cannabis provides symptom relief in a wide range of health conditions

Show Association between the detection of alcohol, illicit drugs and/or psychotropic medications/opioids in patients admitted due to trauma and trauma recidivism: A cohort study. Cordovilla-Guardia S, et al. 2018 Cannabis Open study Alcohol and cannabis use was associated with an increased risk of re-injury

Show Association and Clinical Outcomes of Marijuana in Patients with Intracerebral Hemorrhage. Malhotra K, Rumalla K, Mittal MK. 2018 Cannabis Open study Cannabis use does not increase the risk of stroke due to bleeding in the brain

Show Dependency/withdrawal High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis. Socías ME, Wood E, Lake S, Nolan S, Fairbairn N, Hayashi K, Shulha HP, Liu S, Kerr T, Milloy MJ. 2018 Cannabis Open study Drug addicts have higher retention to opioid replacement treatment if they use cannabis

Show Epilepsy A prospective open-label trial of a CBD/THC cannabis oil in dravet syndrome McCoy B. et al. 2018 Delta-9-THC;Cannabidiol Open study Cannabis extract with high CBD and low THC content effective in childhood epilepsy

Show Pain Cannabinoids and spinal cord stimulation for the treatment of failed back surgery syndrome refractory pain. Mondello E, Quattrone D, Cardia L, Bova G, Mallamace R, Barbagallo AA, Mondello C, Mannucci C, Di Pietro M, Arcoraci V, Calapai G. 2018 Delta-9-THC;Cannabidiol Open study Cannabis improves pain in patients with failed back surgery syndrome

Show Appetite loss/weight loss Efficacy and Safety of Appetite-Stimulating Medications in the Inpatient Setting Howard ML, Hossaini R, Tolar C, Gaviola ML. 2018 Delta-9-THC Open study No difference on reduced appetite between THC, megestrol and mirtazapine

Show Joint culpability: The effects of medical marijuana laws on crime Yu-Wei LukeChu & WilburTownsend 2018 Cannabis Open study Medical cannabis laws in the USA not associated with crime

Show Attention-deficit/hyperactivity disorder ADHD, depression, and substance abuse risk among beginning college students. Mochrie KD, Whited MH, Cellucci T, Freeman T, Corson AT. 2018 Cannabis Survey Students with ADHD are more likely to use cannabis

Show Circulating Endocannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans Azar S. et al. 2018 Other cannabinoids Endocannabinoid levels in obese patients were reduced after surgery against obesity

Show The relationship between cannabis use and diabetes: Results from the National Epidemiologic Survey on Alcohol and Related Conditions III Imtiaz S, Rehm J. 2018 Cannabis Survey Cannabis use is associated with significant reduction in occurrence of diabetes

Show Tourette's syndrome Single center experience with medical cannabis in Gilles de la Tourette syndrome Thaler A, Arad S, Schleider LB, Knaani J, Taichman T, Giladi N, Gurevich T. 2018 Cannabis Open study Cannabis is effective in Tourette syndrome according to a survey

Show Cancer Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol Kenyon J, Liu W, Dalgleish A. 2018 Cannabidiol Open study Cannabidiol may be useful in the treatment of cancer according to an observational study

Show Dependency/withdrawal Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA. Destrée L, Amiet D, Carter A, Lee R, Lorenzetti V, Segrave R, Youssef G, Solowij N, Yücel M. 2018 Cannabis Open study The status of legalisation in US states has no effect on problematic cannabis use

Show Dependency/withdrawal;Depression Sex Differences in the Association Between Cannabis Use and Suicidal Ideation and Attempts, Depression, and Psychological Distress Among Canadians. Halladay JE, Boyle MH, Munn C, Jack SM, Georgiades K. 2018 Cannabis Open study Cannabis use may be associated with an increased risk of suicide

Show Dependency/withdrawal DSM-5 cannabis withdrawal syndrome: Demographic and clinical correlates in U.S. adults Livne O., Shmulewitz D., Lev-Ran S., Hasin D. 2018 Cannabis Survey Cannabis withdrawal syndrome is found in 12% of frequent users

Show Pain The Impact of Cannabis Access Laws on Opioid Prescribing McMichael, Benjamin J. and Van Horn, Ray and Viscusi, W. Kip 2018 Cannabis Survey Cannabis laws in the USA are associated with reduced opioid prescriptions

Show Reduced Incidence and Better Liver Disease Outcomes among Chronic HCV Infected Patients Who Consume Cannabis Adejumo AC, Adegbala OM, Adejumo KL, Bukong TN. 2018 Cannabis Open study Cannabis reduces risk of liver cirrhosis in patients with hepatitis C virus infection

Show Pain Combined THC and CBD to treat pain in epidermolysis bullosa: a report of three cases. Schräder NHB, Duipmans JC, Molenbuur B, Wolff A, Jonkman MF. 2018 Delta-9-THC;Cannabidiol Uncontrolled case report Cannabis effective against pain due to epidermolysis bullosa according to case reports

Show Cancer;Cancer chemotherapy Medical Cannabis Use by Hodgkin Lymphoma Patients: Experience of a Single Center Sarid N. et al. 2018 Cannabis Open study Patients with Hodgkin’s lymphoma may profit from a treatment with cannabis

Show Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study. Aran A, Cassuto H, Lubotzky A, Wattad N, Hazan E. 2018 Cannabidiol Open study Cannabis may be helpful in the treatment of children with autism in an open study

Show Epilepsy Efficacy of cannabinoids in paediatric epilepsy Ali S, Scheffer IE, Sadleir LG. 2018 Cannabidiol Controlled study CBD is similar effective as established antiepileptic drugs

Show Dependency/withdrawal A Survey of Cannabis Acute Effects and Withdrawal Symptoms: Differential Responses Across User Types and Age. Sexton M, Cuttler C, Mischley LK. 2018 Cannabis Survey Differences between medical and recreational cannabis users with regard to withdrawal

Show Pain Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study. Yassin M, Oron A, Robinson D. 2018 Cannabis Open study Cannabis may be beneficial in patients with fibromyalgia and low back pain

Show Should donors who have used marijuana be considered candidates for living kidney donation? Ruckle, D. et al. 2018 Cannabis Open study Cannabis users may be kidney donors

Show Dependency/withdrawal Greater risk for frequent marijuana use and problems among young adult marijuana users with a medical marijuana card. Tucker JS, Rodriguez A, Pedersen ER, Seelam R, Shih RA, D'Amico EJ. 2018 Cannabis Open study Adolescents, who are allowed to use medical cannabis, use cannabis more often

Show Alcohol and Cannabis Use Alter Pulmonary Innate Immunity. 2018 Cannabis Open study Smoking of cannabis may promote airway inflammation

Show Effects of chronic marijuana use on driving performance Doroudgar S, Mae Chuang H, Bohnert K, Canedo J, Burrowes S, Perry PJ. 2018 Cannabis Open study Regular cannabis users had lower driving abilities

Show Amyotrophic lateral sclerosis;Spasticity Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial. Riva N. et al. 2018 Controlled study Cannabis is effective in spasticity due to amyotrophic lateral sclerosis

Show Posttraumatic stress disorder Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. Elms L, Shannon S, Hughes S, Lewis N. 2018 Cannabidiol Uncontrolled case report CBD may be beneficial in the post-traumatic stress disorder according to case series

Show Reduced Prevalence of Alcoholic Gastritis in Hospitalized Individuals Who Consume Cannabis Adejumo AC, Li J, Akanbi O, Adejumo KL, Bukong TN. 2018 Cannabis Open study Cannabis reduces the risk for alcohol-associated gastritis

Show Cortical surface morphology in long-term cannabis users: A multi-site MRI study. Chye Y. et al. 2018 Cannabis Open study Cannabis use not associated with structure of the brain’s cortex

Show Disentangling longitudinal relations between youth cannabis use, peer cannabis use, and conduct problems: developmental cascading links to cannabis use disorder. Defoe IN, Khurana A, Betancourt LM, Hurt H4, Romer D. 2018 Cannabis Open study Cannabis use does not increase conduct problems in young people

Show Epilepsy Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US. Sands TT, Rahdari S, Oldham MS, Caminha Nunes E, Tilton N, Cilio MR. 2018 Cannabidiol Open study Long-term observation of children with epilepsy treated with CBD

Show A meta-analysis of the crash risk of cannabis-positive drivers in culpability studies-Avoiding interpretational bias. Rogeberg O. 2018 Cannabis The risk for traffic accidents caused by cannabis is low

Show Aerobic Fitness Level Moderates the Association Between Cannabis Use and Executive Functioning and Psychomotor Speed Following Abstinence in Adolescents and Young Adults. Wade NE, Wallace AL, Swartz AM, Lisdahl KM. 2018 Cannabis Open study Negative effects of cannabis use on cognition in young people is lower in those with good physical fitness

Show Reduced Risk of Alcohol-Induced Pancreatitis With Cannabis Use. Adejumo AC, Akanbi O, Adejumo KL, Bukong TN. 2018 Cannabis Open study Cannabis use is associated with a reduced risk for alcohol-associated pancreatitis

Show Multiple sclerosis Exploring cannabis use by patients with multiple sclerosis in a state where cannabis is legal. Weinkle L, Domen CH, Shelton I, Sillau S, Nair K, Alvarez E. 2018 Cannabis Survey Many patients with multiple sclerosis use cannabis, if it is legal

Show Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use. Burggren AC. et al. 2018 Cannabis Open study Cannabis users have lower cortical thickness of the hippocampus in the brain

Show Posttraumatic stress disorder Remission of severe, treatment-resistant schizophrenia following adjunctive cannabidiol Makiol C., Kluge M. 2018 Cannabidiol Uncontrolled case report CBD effective in treatment-resistant schizophrenia according to a case report

Show Pain An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia. van de Donk T, Niesters M, Kowal MA, Olofsen E, Dahan A, van Velzen M. 2018 Cannabis Controlled study Cannabis rich in THC may be useful in the treatment of fibromyalgia

Show Associations between cannabis use and cardiometabolic risk factors: A longitudinal study of men. Meier MH, Pardini D, Beardslee J, Matthews KA. 2018 Cannabis Open study Cannabis use is associated with lower risk for factors associated with diseases of heart and blood vessels

Show Epilepsy Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus. Rajaraman RR, Sankar R, Hussain SA. 2018 Cannabidiol Uncontrolled case report CBD may be effective in refractory status epilepticus according to a case report

Show Cancer Cannabinoid receptor expression in estrogen-dependent and estrogen-independent endometrial cancer. Ayakannu T, Taylor AH, Konje JC. 2018 Other cannabinoids Open study Cannabinoid receptors may be therapeutic targets in the treatment or prevention of endometrial cancer

Show Inflammation Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis Karoly HC, Bidwell LC, Mueller RL, Hutchison KE. 2018 Cannabis Open study Cannabis use mitigates inflammation associated with alcohol use

Show Attention-deficit/hyperactivity disorder Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial Cooper RE, Williams E, Seegobin S, Tye C, Kuntsi J, Asherson P 2017 Other cannabinoids Controlled study Cannabis reduced symptoms of ADHD in a small clinical study

Show Pain Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients Fanelli G et al. 2017 Cannabis;Other cannabinoids Open study Cannabis may be effective in the treatment of chronic pain according to a large case series from Italy

Show A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study Jadoon KA, Tan GD, O'Sullivan SE 2017 Cannabidiol Controlled study CBD reduces blood pressure in healthy people

Show Cancer Medical Cannabis in the Palliation of Malignant Wounds—A Case Report Maida V. 2017 Cannabis Uncontrolled case report Topical application of a cannabis extract helpful in cancer wound

Show Multiple sclerosis Cannabis and cognitive functioning in multiple sclerosis: The role of gender Patel VP, Feinstein A 2017 Cannabis Open study Cannabis use may have a negative effect on cognition in male patients with multiple sclerosis

Show Cannabis, Tobacco, Alcohol Use, and the Risk of Early Stroke: A Population-Based Cohort Study of 45 000 Swedish Men Falkstedt D, Wolff V, Allebeck P, Hemmingsson T, Danielsson AK 2017 Cannabis Open study Cannabis use does not increase the risk of stroke in young people, while tobacco does

Show Pain Cannabinoids as effective as pharmaceutical treatments for migraine attacks Gary Scattergood 2017 Other cannabinoids Open study Cannabis effective in migraine and cluster headache in a clinical study

Show Inflammation Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis Annunziata P, Cioni C, Mugnaini C, Corelli F 2017 Open study Activation of the CB2 receptor counteracts inflammation of nerve cells

Show Moderate and vigorous physical activity patterns among marijuana users: Results from the 2007-2014 National Health and Nutrition Examination Surveys Vidot DC, Bispo JB, Hlaing WM, Prado G, Messiah SE 2017 Cannabis Open study Cannabis use was associated with reduced recreational physical activity

Show Association of State Recreational Marijuana Laws With Adolescent Marijuana Use Cerdá M, Wall M, Feng T, Keyes KM, Sarvet A, Schulenberg J, O'Malley PM, Pacula RL, Galea S, Hasin DS 2017 Cannabis Survey Mixed consequences of cannabis legalization on cannabis use by adolescents

Show How does marijuana affect outcomes after trauma in ICU patients? A propensity-matched analysis Singer M, Azim A, O'Keeffe T, Khan M, Jain A, Kulvatunyou N, Gries L, Jehan F, Tang A, Joseph B 2017 Cannabis Open study Cannabis use may decrease mortality in trauma patients

Show Cancer;Pain Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies. Fallon MT et al. 2017 Cannabidiol;Other cannabinoids Controlled study A cannabis extract did not reduce pain in advanced cancer patients, who did not respond to opioids

Show Tourette's syndrome Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients Jakubovski E, Müller-Vahl K 2017 Cannabis;Delta-9-THC Uncontrolled case report Speechlessness in Tourette syndrome may be treated with cannabis/THC according to case reports

Show Pain Perioperative Patient Beliefs Regarding Potential Effectiveness of Marijuana (Cannabinoids) for Treatment of Pain: A Prospective Population Survey Khelemsky Y et al. 2017 Cannabis Survey More than 80% of patients believe that cannabis may reduce pain

Show Epilepsy Interactions between cannabidiol and commonly used antiepileptic drugs Gaston TE, Bebin EM, Cutter GR, Liu Y, Szaflarski JP; UAB CBD Program 2017 Cannabidiol Open study : CBD interacts with other anti-epileptic drugs

Show Spinal cord injury Cannabis use in persons with traumatic spinal cord injury in Denmark Andresen SR, Biering-Sørensen F, Hagen EM, Nielsen JF, Bach FW, Finnerup NB 2017 Cannabis Survey Cannabis use is more frequent among people with spinal cord injury than among the general population

Show Pain Topical Medical Cannabis: A New Treatment for Wound Pain-Three Cases of Pyoderma Gangrenosum Maida V, Corban J 2017 Cannabis Uncontrolled case report Topical cannabis reduced wound pain in a small case series

Show HIV/AIDS Confirmed marijuana use and lymphocyte count in black people living with HIV Keen L 2nd, Abbate A, Blanden G, Priddie C, Moeller FG, Rathore M 2017 Cannabis Open study Cannabis has no negative effect on the immune system in patients with HIV

Show Spinal cord injury Delta-9-tetrahydrocannabinol-cannabidiol in the treatment of spasticity in chronic spinal cord injury: a clinical experience Grao-Castellote C, Torralba-Collados F, Gonzalez LM, Giner-Pascual M 2017 Other cannabinoids Open study Cannabis may be helpful in patients with spinal cord injuries according to an observational study

Show Appetite loss/weight loss Association Between Use of Cannabis in Adolescence and Weight Change into Midlife Jin LZ, Rangan A, Mehlsen J, Andersen LB, Larsen SC4, Heitmann BL 2017 Cannabis Open study Cannabis use during adolescence not associated with weight in midlife

Show Anxiety Association of cannabis use with the development of elevated anxiety symptoms in the general population: a meta-analysis Twomey CD. 2017 Cannabis No relevant association between cannabis use and anxiety in the general population

Show Effect of food on the pharmacokinetics of dronabinol oral solution versus dronabinol capsules in healthy volunteers Oh DA, Parikh N, Khurana V, Cognata Smith C, Vetticaden S 2017 Other cannabinoids Open study Maximum blood concentrations after oral intake of THC were reached faster in a fasted state than in if taken together with a meal

Show Pain Patient Perceptions of the Use of Medical Marijuana in the Treatment of Pain After Musculoskeletal Trauma: A Survey of Patients at 2 Trauma Centers in Massachusetts Heng, Marilyn et al. 2017 Cannabis;Other cannabinoids Survey Trauma patients find relief from a treatment with cannabis according to a survey

Show Parkinson's disease Cannabis use in people with Parkinson's disease and Multiple Sclerosis: A web-based investigation Kindred JH, Li K, Ketelhut NB, Proessl F, Fling BW, Honce JM, Shaffer WR, Rudroff T 2017 Cannabis Survey Cannabis may be helpful in Parkinson’s disease according to a survey

Show Amyotrophic lateral sclerosis Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease: A Case Report Nahler G. 2017 Cannabidiol Uncontrolled case report Cannabidiol slowed progression of amyotrophic lateral sclerosis in a case report

Show Evaluation of divided attention psychophysical task performance and effects on pupil sizes following smoked, vaporized and oral cannabis administration Newmeyer MN, Swortwood MJ, Taylor ME, Abulseoud OA, Woodward TH, Huestis MA 2017 Cannabis Controlled study Effects of inhaled and oral THC on pupil size and psychomotor performance

Show Cannabis for restless legs syndrome: a report of six patients Megelin T., Ghorayeb I. 2017 Cannabis Uncontrolled case report Cannabis may be helpful in restless legs syndrome according to case reports

Show Smoked marijuana attenuates performance and mood disruptions during simulated night shift work Keith DR, Gunderson EW, Haney M, Foltin RW, Hart CL 2017 Cannabis Open study The use of cannabis improves performance during simulated night shift work

Show Psychosis/schizophrenia Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators Bourque J, Afzali MH, O'Leary-Barrett M, Conrod P 2017 Cannabis Open study Cannabis use in adolescents was associated with psychotic-like experiences

Show Psychosis/schizophrenia Effect of continued cannabis use on medication adherence in the first two years following onset of psychosis Schoeler T, Petros N, Di Forti M, Klamerus E, Foglia E, Murray R, Bhattacharyya S 2017 Cannabis Open study Heavy cannabis use may reduce adherence to medication in patients with psychosis

Show Multiple sclerosis;Spasticity Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-Tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis. van Amerongen G, Kanhai K, Baakman AC, Heuberger J, Klaassen E, Beumer TL, Strijers RL, Killestein J, van Gerven J, Cohen A, Groeneveld GJ 2017 Delta-9-THC Controlled study THC showed mixed results in the treatment of pain and spasticity in multiple sclerosis

Show Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome Cremon C et el. 2017 Controlled study A treatment with palmithoylethanolamide and polydatin improved pain in irritable bowel syndrome

Show Nausea/vomiting A randomized-controlled trial of nabilone for the prevention of acute postoperative nausea and vomiting in elective surgery Levin DN, Dulberg Z, Chan AW, Hare GM, Mazer CD, Hong A 2017 Nabilone Controlled study Nabilone was not effective in reducing postoperative nausea and vomiting

Show Epilepsy Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy Aguirre-Velázquez CG 2017 Cannabis Survey;Basic research CBD-rich cannabis reduced seizures in children with epilepsy according to a survey

Show Cannabis as a substitute for prescription drugs - a cross-sectional study Corroon JM Jr, Mischley LK, Sexton M 2017 Cannabis Survey Cannabis is used as a substitute for prescription drugs according to a large survey

Show Posttraumatic stress disorder Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders Ruglass LM, et al. 2017 Cannabis Open study Cannabis use had no relevant influence on outcome of behavioural therapies for co-occurring PTSD and substance use disorders

Show Inflammation Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids Utomo WK, et al. 2017 Open study Cannabis use alters immune cells in a way, which supports beneficial effects in inflammatory diseases and cancer

Show Psychosis/schizophrenia Association between alcohol, cannabis, and other illicit substance abuse and risk of developing schizophrenia: a nationwide population based register study Nielsen SM, Toftdahl NG, Nordentoft M, Hjorthøj C 2017 Cannabis Open study Cannabis and alcohol use were associated with increased risk of schizophrenia

Show Epilepsy;Rare diseases Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome Devinsky O, Cross JH, Laux L, Marsh E, Miller I, Nabbout R, Scheffer IE, Thiele EA, Wright S; Cannabidiol in Dravet Syndrome Study Group. 2017 Cannabidiol Controlled study Cannabidiol effective against epilepsy in Dravet syndrome

Show Older adults' marijuana use, injuries, and emergency department visits Choi NG, Marti CN, DiNitto DM, Choi BY 2017 Cannabis Controlled study Cannabis use may increase injury risk among older adults

Show Medical cannabis access, use, and substitution for prescription opioids and other substances: A survey of authorized medical cannabis patients Lucas P, Walsh Z 2017 Cannabis Survey Patients prefer cannabis over opioids

Show Cumulative Lifetime Marijuana Use and Incident Cardiovascular Disease in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Reis JP, et al. 2017 Cannabis Open study Cannabis use not associated with higher risk of cardiovascular diseases

Show Tourette's syndrome Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome Abi-Jaoude E, Chen L, Cheung P, Bhikram T, Sandor P 2017 Cannabis Uncontrolled case report Cannabis effective in Tourette syndrome in case series

Show Prolonged cannabis withdrawal in young adults with lifetime psychiatric illness. Schuster RM, Fontaine M, Nip E, Zhang H, Hanly A, Evins AE 2017 Cannabis Survey Prolonged withdrawal symptoms in young cannabis users with psychiatric diseases

Show Depression Depression and anxiety among chronic pain patients receiving prescription opioids and medical marijuana Feingold D, Brill S, Goor-Aryeh I, Delayahu Y, Lev-Ran S 2017 Cannabis Open study Depression is higher in pain patients receiving opioids compared to those receiving cannabis

Show Childhood academic ability in relation to cigarette, alcohol and cannabis use from adolescence into early adulthood: Longitudinal Study of Young People in England (LSYPE). Williams J, Hagger-Johnson G 2017 Cannabis Survey High academic ability reduced the risk of tobacco smoking but increased the risk of cannabis use in adolescents

Show HIV/AIDS Marijuana Use Impacts Midlife Cardiovascular Events in HIV-Infected Men 2017 Cannabis Open study Cannabis use may increase the risk for heart attacks in HIV positives

Show Depression Cannabis use and the course and outcome of major depressive disorder: A population based longitudinal study. Feingold D, Rehm J, Lev-Ran S 2017 Cannabis Open study No association between cannabis use and depression

Show Pain Fatty Acid Amide Hydrolase Inhibitor Treatment in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: An Adaptive Double-blind, Randomized Controlled Trial. Wagenlehner FM, et al. 2017 Other cannabinoids Controlled study An inhibitor of FAAH did not influence pain in patients with chronic prostatitis

Show Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized study Faig-Martí J, Martínez-Catassús A 2017 Other cannabinoids Controlled study Palmitoylethanolamide moderately effective in the treatment of carpal tunnel syndrome

Show Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study Androvicova R, et al. 2017 Cannabis Open study Cannabis increases the reaction to erotic stimuli

Show Pain Chronic pain patients' perspectives of medical cannabis Piper BJ, Beals ML, Abess AT, Nichols SD, Martin M, Cobb CM, DeKeuster RM. 2017 Cannabis Survey Medical cannabis patients rate cannabis as very effective

Show Cannabis use patterns and motives: A comparison of younger, middle-aged, and older medical cannabis dispensary patients. Haug NA, Padula CB, Sottile JE, Vandrey R, Heinz AJ, Bonn-Miller MO 2017 Cannabis Survey : Low age associated with higher problematic cannabis use among medical cannabis users

Show Long lasting effects of chronic heavy cannabis abuse Nestoros JN, Vakonaki E, Tzatzarakis MN, Alegakis A, Skondras MD, Tsatsakis AM 2017 Cannabis Open study Very heavy cannabis use may have long-lasting effects on the brain

Show Medical Marijuana Laws May Be Associated With A Decline In The Number Of Prescriptions For Medicaid Enrollees Bradford AC, Bradford WD 2017 Cannabis Open study The medical use of cannabis may reduce medical costs of Medicaid in the USA by about one billion dollars

Show Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study. Adejumo AC et al. 2017 Cannabis Survey Cannabis use is associated with a lower prevalence of non-alcoholic fatty liver disease according to a large study

Show Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial. Naftali T, et al. 2017 Cannabidiol Controlled study Very low doses of CBD were not effective in Crohn’s disease

Show Psychosis/schizophrenia The impact of current cannabis use on general cognitive function in people with psychotic illness Waterreus A, Badcock JC, Di Prinzio P, Martin-Iverson M, Morgan VA 2017 Cannabis Controlled study No difference in cognitive abilities between people with psychosis with and without cannabis use

Show Is Cannabis Use Associated with Various Indices of Motivation Among Adolescents? Pacheco-Colón I, Coxe S, Musser ED, Duperrouzel JC, Ross JM, Gonzalez R 2017 Cannabis Open study

Show Obsessive compulsive disorder Refractory OCD Due to Thalamic Infarct With Response to Dronabinol Cooper JJ, Grant J 2017 Delta-9-THC Uncontrolled case report

Show Pain The MOBILE Study-A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Patients with Peripheral Neuropathic Pain. Bradford D et al. 2017 Other cannabinoids Controlled study A FAAH inhibitor did not reduce neuropathic pain

Show Dependency/withdrawal Intentional cannabis use to reduce crack cocaine use in a Canadian setting: A longitudinal analysis Socías ME et al. 2017 Cannabis Open study Cannabis use reduced crack use

Show Tourette's syndrome Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome Abi-Jaoude E, Chen L, Cheung P, Bhikram T, Sandor P 2017 Cannabis Open study Cannabis improved symptoms of Tourette syndrome

Show Dependency/withdrawal Hill KP et al. 2017 Nabilone Open study Nabilone reduced cannabis use in cannabis-dependent persons

Show Parkinson's disease Medical Cannabis in Parkinson Disease: Real-Life Patients' Experience Balash Y et al. 2017 Cannabis Open study Cannabis may be beneficial in Parkinson`s disease according to a survey

Show Epilepsy The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy Warren PP, Bebin EM, Nabors LB, Szaflarski JP 2017 Cannabidiol Uncontrolled case report CBD may be effective in epilepsy due to brain tumours according to a case series

Show Multiple sclerosis;Pain Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients Schimrigk S et al. 2017 Other cannabinoids Open study No significant difference between placebo and THC in the treatment of pain of patients with multiple sclerosis

Show Appetite loss/weight loss The Impact of Δ9-THC on the Psychological Symptoms of Anorexia Nervosa: A Pilot Study Avraham Y, Latzer Y, Hasid D, Berry EM 2017 Delta-9-THC Open study THC may improve symptoms of anorexia nervosa

Show Pain Medical Cannabis in Patients with Chronic Pain: Effect on Pain Relief, Pain Disability, and Psychological aspects. A Prospective Non randomized Single Arm Clinical Trial. Poli P, Crestani F, Salvadori C, Valenti I, Sannino C. 2017 Cannabis Open study Cannabis tea effective in the treatment of chronic pain

Show Pain;Parkinson's disease Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease. Shohet A, Khlebtovsky A, Roizen N, Roditi Y, Djaldetti R. 2016 Cannabis Open study Cannabis use improved pain and movement

Show Epilepsy Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex. Hess EJ, Moody KA, Geffrey AL, Pollack SF, Skirvin LA, Bruno PL, Paolini JL, Thiele EA. 2016 Cannabidiol Open study cannabidiol (CBD) was shown to be effective in the treatment of epilepsy due to Tuberous sclerosis complex

Show Epilepsy Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases. Gofshteyn JS, Wilfong A, Devinsky O, Bluvstein J, Charuta J, Ciliberto MA, Laux L, Marsh ED. 2016 Cannabidiol Uncontrolled case report Cannabidiol is effective in febrile infection-related epilepsy syndrome in a case series

Show Parkinson's disease Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease. Shohet A, Khlebtovsky A, Roizen N, Roditi Y, Djaldetti R. 2016 Cannabis Open study Cannabis improves pain and movement in patients with Parkinson’s disease

Show Pain A preliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis. Wilsey BL, Deutsch R, Samara E, Marcotte TD, Barnes AJ, Huestis MA, Le D. 2016 Delta-9-THC Controlled study Moderate relationship between THC concentrations and reduction of pain

Show Effects of tetrahydrocannabinol on balance and gait in patients with dementia: A randomised controlled crossover trial. van den Elsen GA, Tobben L, Ahmed AI, Verkes RJ, Kramers C, Marijnissen RM, Olde Rikkert MG, van der Marck MA. 2016 Delta-9-THC Controlled study No differences in the number and type of adverse events were found, and no falls occurred after administration of THC.

Show Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study. Jadoon KA, Ratcliffe SH, Barrett DA, Thomas EL, Stott C, Bell JD, O'Sullivan SE, Tan GD. 2016 Other cannabinoids Controlled study THCV significantly decreased fasting plasma glucose and improved the function of cells in the pancreas

Show Epilepsy Marijuana use in adults admitted to a Canadian epilepsy monitoring unit. Massot-Tarrús A, McLachlan RS. 2016 Cannabis Survey Improvement in seizures, stress was decreased, sleep improved and memory/concentration was better

Show Spasticity Effective treatment of spasticity using dronabinol in pediatric palliative care. Kuhlen M, Hoell JI, Gagnon G, Balzer S, Oommen PT, Borkhardt A, Janßen G. 2016 Delta-9-THC In the majority of pediatric palliative patients the treatment with dronabinol showed promising effects in treatment resistant spasticit.

Show Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure. De Sousa Fernandes Perna EB, Theunissen EL, Kuypers KP, Toennes SW, Ramaekers JG. 2016 Cannabis Subjective aggression significantly increased following aggression exposure in all groups while being sober.

Show Pain;Spinal cord injury An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease. Wilsey B, Marcotte TD, Deutsch R, Zhao H, Prasad H, Phan A. 2016 Cannabis Controlled study Inhaled cannabis reduces neuropathic pain in patients with spinal cord injury

Show Bipolar disorders Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood. Sagar KA, Dahlgren MK, Racine MT, Dreman MW, Olson DP, Gruber SA. 2016 Cannabis Controlled study Cannabis showed beneficial effects in bipolar disorder

Show Multiple sclerosis The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity. Marinelli L, Mori L, Canneva S, Colombano F, Currà A, Fattapposta F, Bandini F, Capello E, Abbruzzese G, Trompetto C. 2016 Cannabis Controlled study Cannabis reduces the stretch reflex in patients with multiple sclerosis

Show Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage. Di Napoli M, Zha AM, Godoy DA, Masotti L, Schreuder FH, Popa-Wagner A, Behrouz R; MNEMONICH Registry. 2016 Cannabis Open study Cannabinoids-positive patients had lower median disease scores on admission

Show Pain Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial. Malik Z, Bayman L, Valestin J, Rizivi-Toner A, Hashmi S, Schey R. 2016 Delta-9-THC Controlled study THC reduced pain intensity and odynophagia (painful swallowing, in the mouth or oesophagus).

Show Epilepsy CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. Tzadok M, Uliel-Siboni S, Linder I, Kramer U, Epstein O, Menascu S, Nissenkorn A, Yosef OB, Hyman E, Granot D, Dor M, Lerman-Sagie T, Ben-Zeev B. 2016 Cannabidiol Controlled study Improvement in behaviour and alertness, language, communication, motor skills and sleep

Show Multiple sclerosis Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis. Russo M, Naro A, Leo A, Sessa E, D'Aleo G, Bramanti P, Calabrò RS. 2016 Other cannabinoids Open study Cannabis reduced neuropathic pain

Show Alzheimer's disease Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study. Shelef A, Barak Y, Berger U, Paleacu D, Tadger S, Plopsky I, Baruch Y. 2016 Cannabis Open study Following aspects significantly decreased: Delusions, agitation/aggression, irritability, apathy, and sleep and caregiver distress

Show Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population. Rhyne DN, Anderson S, Gedde M, Borgelt LM. 2016 Other cannabinoids Controlled study Migraine headache frequency on average decreased from 10.4 to 4.6 headaches per month with the use of cannabis.

Show Attention-deficit/hyperactivity disorder Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial R.E. Cooper, E. Williams, S. Seegobin, C. Tye, J. Kuntsi, P. Asherson 2016 Delta-9-THC;Cannabidiol Controlled study Cannabis may be helpful in the treatment of ADHD

Show Bipolar disorders Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood Sagar KA, Dahlgren MK, Racine MT, Dreman MW, Olson DP, Gruber SA. 2016 Cannabis Open study Cannabis may be helpful in bipolar disorder

Show Dependency/withdrawal Safety of oral dronabinol during opioid withdrawal in humans Jicha CJ, Lofwall MR, Nuzzo PA, Babalonis S, Elayi SC, Walsh SL. 2015 Delta-9-THC Controlled study 40 mg of THC caused increased heart rate and anxiety, which made dose-reduction necessary

Show Epilepsy Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy Press CA, Knupp KG, Chapman KE 2015 Cannabis Open study About one third of children suffering from different forms of epilepsy experienced a more than 50 % reduction in seizures by the use of oral cannabis extracts.

Show Pain Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy Wallace MS, Marcotte TD, Umlauf A, Gouaux B, Atkinson JH 2015 Cannabis Controlled study Inhaled cannabis demonstrated a dose dependent reduction in peripheral treatment-refractory neuropathic pain.

Show Profiles of medicinal cannabis patients attending compassion centers in rhode island. Zaller N, Topletz A, Frater S, Yates G, Lally M. 2015 Cannabis Survey Most participants report that medicinal cannabis improves their pain symptomology.

Show Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers. Tudge L, Williams C, Cowen PJ, McCabe C 2015 Other cannabinoids Controlled study The natural cannabinoid tetrahydrocannabivarin (THCV) altered the nerve response to pleasant and unpleasant stimuli in a way that it “suggests therapeutic activity in obesity.

Show Posttraumatic stress disorder The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study. Jetly R, Heber A, Fraser G, Boisvert D. 2015 Nabilone Controlled study Nabilone reduced nightmares.

Show Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples Alshaarawy O, Anthony JC. 2015 Cannabis Survey Cannabis use was associated with a 30% reduction of diabetes risk

Show Pain Experience of adjunctive cannabis use for chronic non-cancer pain: Findings from the Pain and Opioids IN Treatment (POINT) study. Degenhardt L, Lintzeris N, Campbell G, Bruno R, Cohen M, Farrell M, Hall WD. 2015 Cannabis Survey Pain patients, who receive opioids, experience better pain relief if they also take cannabis.

Show HIV/AIDS High-intensity cannabis use associated with lower plasma human immunodeficiency virus-1 RNA viral load among recently infected people who use injection drugs. Milloy MJ, Marshall B, Kerr T, Richardson L, Hogg R, Guillemi S, Montaner JS, Wood E. 2015 Cannabis Open study At least daily cannabis use was associated with significant lower plasma HIV viral loads.

Show Cancer Patterns of Use of Medical Cannabis Among Israeli Cancer Patients: A Single Institution Experience. Waissengrin B, Urban D, Leshem Y, Garty M, Wolf I. 2015 Cannabis Open study Cannabis use “is perceived as highly effective” by some patients with advanced cancer.

Show Cancer;Nausea/vomiting Dronabinol Treatment of Refractory Nausea and Vomiting Related to Peritoneal Carcinomatosis. Hernandez SL, Sheyner I, Stover KT, Stewart JT. 2015 Delta-9-THC Open study THC may be very effective in the treatment of nausea and vomiting in end-stage cancer.

Show Appetite loss/weight loss;Cancer;Nausea/vomiting;Pain Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial Côté M, Trudel M, Wang C, Fortin A. 2015 Nabilone Controlled study Nabilone did not reduce pain and nausea in patients treated for head and neck cancer.

Show Pain Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability de Vries M, van Rijckevorsel DC, Vissers KC, Wilder-Smith OH, van Goor H(; Pain and Nociception Neuroscience Research Group 2015 Delta-9-THC Controlled study No effect of a single low dose of THC on abdominal pain resulting from chronic pancreatitis in clinical study.

Show Dependency/withdrawal;Pain The prescription of medical cannabis by a transitional pain service to wean a patient with complex pain from opioid use following liver transplantation: a case report. Meng H, Hanlon JG, Katznelson R, Ghanekar A, McGilvray I, Clarke H. 2015 Cannabis Uncontrolled case report The use of cannabis reduced opioid consumption

Show Alzheimer's disease Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: A randomized controlled trial. van den Elsen GA, Ahmed AI, Verkes RJ, Kramers C, Feuth T, Rosenberg PB, van der Marck MA, Olde Rikkert MG. 2015 Delta-9-THC Controlled study No reduction in NPS by low-dose THC (3x1.5mg), though it is well-tolerated

Show Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled study in cannabis users. Hindocha C, Freeman TP, Schafer G, Gardener C, Das RK, Morgan CJ, Curran HV. 2015 Cannabis;Delta-9-THC;Cannabidiol Controlled study Improvement of recognition of emotional facial affect by CBD and attenuation of the impairment induced by THC

Show The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial. Englund A, Atakan Z, Kralj A, Tunstall N, Murray R, Morrison P. 2015 Delta-9-THC Controlled study Inhibition of some of the well-known effects of THC by THCV and potentiation of other effects

Show Epilepsy Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MR. 2015 Cannabidiol Open study Cannabidiol reduces seizure frequency in epilepsy of children and young adults

Show Pain The Pharmacokinetics, Efficacy, Safety, and Ease of Use of a Novel Portable Metered-Dose Cannabis Inhaler in Patients With Chronic Neuropathic Pain: A Phase 1a Study Eisenberg E, Ogintz M, Almog S 2014 Cannabis Open study A significant reduction in pain intensity was achieved after cannabis inhalation with a vaporizer.

Show Dependency/withdrawal Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial Allsop DJ, Copeland J, Lintzeris N, Dunlop AJ, Montebello M, Sadler C, Rivas GR, Holland RM, Muhleisen P, Norberg MM, Booth J, McGregor IS 2014 Cannabis Controlled study Sativex had no relevant long-term effect on cannabis dependence

Show Pain A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment Serpell M, Ratcliffe S, Hovorka J, Schofield M, Taylor L, Lauder H, Ehler E 2014 Cannabis Controlled study Significant improvements in pain, sleep quality and subjective evaluations of patients.

Show Parkinson's disease Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA 2014 Cannabidiol Controlled study Significant improvement in well-being. No effects on motor functioning or neuroprotection.

Show Endocannabinoids control platelet activation and limit aggregate formation under flow. De Angelis V, Koekman AC, Weeterings C, Roest M, de Groot PG, Herczenik E, Maas C. 2014 Other cannabinoids Open study Activation of cannabinoid receptors by cannabis use reduces platelet activation and blood clotting.

Show Traumatic brain injury Effect of marijuana use on outcomes in traumatic brain injury. Nguyen BM, Kim D, Bricker S, Bongard F, Neville A, Putnam B, Smith J, Plurad D. 2014 Cannabis Open study A positive THC screen is associated with decreased mortality in adult patients sustaining TBI [traumatic brain injury].

Show Safety and pharmacokinetics of oral delta-9-tetrahydrocannabinol in healthy older subjects: A randomized controlled trial. Ahmed AI, van den Elsen GA, Colbers A, van der Marck MA, Burger DM, Feuth TB, Rikkert MG, Kramers C. 2014 Delta-9-THC Controlled study THC appeared to be safe and well tolerated by healthy older individuals.

Show Nausea/vomiting Cannabis for intractable nausea after bilateral cerebellar stroke. Adhiyaman V, Arshad S. 2014 Cannabis Uncontrolled case report A woman with intractable nausea after cerebellar stroke responded well to a treatment with THC.

Show Pain;Posttraumatic stress disorder;Sleep disorder Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder-Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications: A Retrospective Evaluation. Cameron C, Watson D, Robinson J. 2014 Nabilone Open study Nabilone caused significant improvements in insomnia, nightmares, chronic pain and other symptoms in patients suffering from posttraumatic stress disorder (PTSD).

Show Multiple sclerosis Long-term effectiveness and safety of nabiximols (tetrahydrocannabinol/cannabidiol oromucosal spray) in clinical practice. Flachenecker P, Henze T, Zettl UK. 2014 Cannabis Open study Researchers found that “real-life data confirm the long-term effectiveness and tolerability of nabiximols [Sativex] for the treatment of resistant MSS [multiple sclerosis spasticity].

Show Posttraumatic stress disorder Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder. Roitman P, Mechoulam R, Cooper-Kazaz R, Shalev A. 2014 Delta-9-THC Open study THC caused significant improvements in post-traumatic stress disorder (PTSD).

Show Parkinson's disease Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study. Lotan I, Treves TA, Roditi Y, Djaldetti R. 2014 Cannabis Open study Analysis of specific motor symptoms revealed significant, also sleep and pain improvement after treatment with cannabis.

Show Multiple sclerosis Nabiximols (THC/CBD oromucosal spray, Sativex®) in clinical practice--results of a multicenter, non-interventional study (MOVE 2) in patients with multiple sclerosis spasticity. Flachenecker P, Henze T, Zettl UK. 2014 Cannabis Open study The cannabis extract Sativex provided relief in 74.6% of participants.

Show Posttraumatic stress disorder Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD. Bonn-Miller MO, Babson KA, Vandrey R. 2014 Cannabis Survey Patients with high PTSD scores were more likely to use cannabis to improve sleep, and for coping reasons more generally.

Show Sleep disorder Impact of Dronabinol on Quantitative Electroencephalogram (qEEG) Measures of Sleep in Obstructive Sleep Apnea Syndrome. Farabi SS, Prasad B, Quinn L, Carley DW. 2014 Delta-9-THC Open study THC treatment yielded a shift in EEG (electroencephalogram) power toward delta and theta frequencies and a strengthening of normal rhythms in the sleep.

Show Multiple sclerosis;Spasticity Clinical experience with THC:CBD oromucosal spray in patients with multiple sclerosis-related spasticity. Koehler J, Feneberg W, Meier M, Pöllmann W. 2014 Cannabis Open study The mean spasticity decreased by 57%.

Show Multiple sclerosis;Spasticity Clinical experiences with cannabinoids in spasticity management in multiple sclerosis. Lorente Fernández L, Monte Boquet E, Pérez-Miralles F, Gil Gómez I, Escutia Roig M, Boscá Blasco I, Poveda Andrés JL, Casanova-Estruch B. 2014 Cannabis Open study The cannabis extract was effective in 80% of patients.

Show Alzheimer's disease Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms. Woodward MR, Harper DG, Stolyar A, Forester BP, Ellison JM. 2014 Delta-9-THC Open study A treatment with oral THC was associated with significant decreases in agitation, as well as improvements in sleep duration and appetite.

Show Epilepsy Cannabis and other illicit drug use in epilepsy patients. Hamerle M, Ghaeni L, Kowski A, Weissinger F, Holtkamp M. 2014 Cannabis Survey The use of cannabis did not affect disease severity in epilepsy.

Show Pain A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain. Lynch ME, Cesar-Rittenberg P, Hohmann AG. 2014 Cannabis Controlled study Reduction in pain intensity

Show Pain The subjective psychoactive effects of oral dronabinol studied in a randomized, controlled crossover clinical trial for pain. Issa MA, Narang S, Jamison RN, Michna E, Edwards RR, Penetar DM, Wasan AD. 2014 Cannabis;Delta-9-THC Controlled study Oral THC had similar psychoactive effects to smoked marijuana

Show Multiple sclerosis;Spasticity Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial. Zajicek J, Ball S, Wright D, Vickery J, Nunn A, Miller D, Cano MG, McManus D, Mallik S, Hobart J; on behalf of the CUPID investigator group. 2013 Delta-9-THC Controlled study THC, which was given for 36 months, had no effect on progression compared to placebo

Show Dependency/withdrawal Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment. Scavone JL, Sterling RC, Weinstein SP, Van Bockstaele EJ. 2013 Cannabis Open study Objective ratings of opiate withdrawal decreased in patients using cannabis during stabilization

Show Cancer chemotherapy;Pain A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced Neuropathic Pain. Lynch ME, Cesar-Rittenberg P, Hohmann AG. 2013 Cannabis Controlled study Five patients tended to respond to a treatment with cannabis

Show Anxiety;Posttraumatic stress disorder Cannabidiol enhances consolidation of explicit fear extinction in humans. Das RK, Kamboj SK, Ramadas M, Yogan K, Gupta V, Redman E, Curran HV, Morgan CJ 2013 Cannabidiol Controlled study Cannabidiol enhances consolidation of fear extinction in humans.

Show Dependency/withdrawal Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report. Crippa JA, Hallak JE, Machado-de-Sousa JP, Queiroz RH, Bergamaschi M, Chagas MH, Zuardi AW. 2013 Cannabidiol Uncontrolled case report They were no major withdrawal symptoms.

Show Dependency/withdrawal Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in Canadian medical cannabis patients. Lucas P, Reiman A, Earleywine M, McGowan S, Oleson M, Coward M, Thomas B. 2013 Cannabis Survey Many patients substitute cannabis for alcohol, illegal and medicinal drugs

Show Psychosis/schizophrenia A controlled family study of cannabis users with and without psychosis. Proal AC, Fleming J, Galvez-Buccollini JA, Delisi LE. 2013 Cannabis Controlled study Cannabis does not cause psychosis by itself

Show Pain The Subjective Psychoactive Effects of Oral Dronabinol Studied in a Randomized, Controlled Crossover Clinical Trial For Pain. Issa MA, Narang S, Jamison RN, Michna E, Edwards RR, Penetar DM, Wasan AD. 2013 Cannabis;Delta-9-THC Controlled study In pain patients, oral dronabinol has similar psychoactive effects to smoking cannabis.

Show Cancer;Pain An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics Johnson JR, Lossignol D, Burnell-Nugent M, Fallon MT 2013 Cannabis Open study The cannabis extract Sativex was generally well tolerated, with no evidence of a loss of effect for pain relief.

Show Multiple sclerosis;Pain A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis. Langford RM, Mares J, Novotna A, Vachova M, Novakova I, Notcutt W, Ratcliffe S 2013 Cannabis Controlled study No significant difference between placebo and Sativex in Phase A; Phase B demonstrated an analgesic effect.

Show Gastrointestinal disorder;Inflammation;Pain Konikoff FM. Cannabis induces a clinical response in patients with Crohn's disease: a prospective placebo-controlled study Naftali T, Bar-Lev Schleider L, Dotan I, Lansky EP, Sklerovsky Benjaminov F, Konikoff FM 2013 Cannabis Controlled study Cannabis produced significant clinical benefits in 10 of 11 patients with active Crohn’s disease.

Show Pain Low-dose vaporized cannabis significantly improves neuropathic pain Wilsey B, Marcotte T, Deutsch R, Gouaux B, Sakai S, Donaghe H 2013 Cannabis Controlled study Cannabis reduced pain. No difference in efficacy between the two doses.

Show Gastrointestinal disorder;Inflammation Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease. Ravikoff Allegretti J, Courtwright A, Lucci M, Korzenik JR, Levine J. 2013 Cannabis Survey Patients find cannabis very helpful for symptom control.

Show Sleep disorder Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers. Gorelick DA, Goodwin RS, Schwilke E, Schroeder JR, Schwope DM, Kelly DL, Ortemann-Renon C, Bonnet D, Huestis MA. 2013 Delta-9-THC Open study Higher THC concentrations were significantly associated with less difficulty falling asleep and more daytime sleep the following day.

Show Cancer The medical necessity for medicinal cannabis: prospective, observational study evaluating the treatment in cancer patients on supportive or palliative care. Bar-Sela G, Vorobeichik M, Drawsheh S, Omer A, Goldberg V, Muller E. 2013 Cannabis Open study In an open clinical study with cancer patients all symptoms improved significantly.

Show HIV/AIDS Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis. Brunet L, Moodie EE, Rollet K, Cooper C, Walmsley S, Potter M, Klein MB; Canadian Co-infection Cohort Investigators. 2013 Cannabis Open study The use of cannabis did not accelerate progression to significant liver fibrosis.

Show Dependency/withdrawal Impact of cannabis use during stabilization on methadone maintenance treatment. Scavone JL, Sterling RC, Weinstein SP, Van Bockstaele EJ. 2013 Cannabis Open study Symptoms of opiate withdrawal decrease in patients undergoing methadone maintenance treatment, who use cannabis.

Show Multiple sclerosis Treatment failure of intrathecal baclofen and supra-additive effect of nabiximols in multiple sclerosis-related spasticity: a case report. Stroet A, Trampe N, Chan A. 2013 Cannabis Uncontrolled case report A combination of baclofen injections 