A lone male suicide bomber was behind the terror attack that killed more than 20 people during an Ariana Grande concert at Manchester Arena, police have said.

Police raised the death toll to 22 and said children were among those killed.

A total of 59 people were left injured in the blast.

Greater Manchester Police chief constable Ian Hopkins, confirmed the attack was carried out by one man although at this stage police do not know if the bomber "acted alone or was part of a wider network".

He said the attacker, who died at the scene, was carrying an improvised explosive device which he detonated.

Mr Hopkins said: "This has been the most horrific incident we have had to face in Greater Manchester and one that we all hoped we would never see.

"Families and many young people were out to enjoy a concert at the Manchester Arena and have lost their lives.

"Our thoughts are with those 22 victims that we now know have died, the 59 people who have been injured and their loved ones.

"We continue to do all we can to support them."

Witnesses reported hearing a "huge bomb-like bang" at around 10.30pm on Monday, as fans were leaving the arena shortly after a show by Ariana Grande finished, and described glass and metal nuts on the floor.

Some witnesses described seeing smoke and smelling burning in the foyer area of the arena.

The Prime Minister has condemned the "appalling" incident and General Election campaigning has been suspended.

Manchester explosion in pictures Show all 37 1 /37 Manchester explosion in pictures Manchester explosion in pictures People running down stairs as they attempt to exit the Manchester Arena after a blast, where U.S. singer Ariana Grande had been performing, in Manchester Twitter/@ZACH_BRUCE/ via REUTERS Manchester explosion in pictures Helpers attend to people inside the Manchester Arena after a suspected suicide bomber detonated an explosive device at the end of an Ariana Grande concert, killing 22 people PA wire Manchester explosion in pictures Armed officers guard outside a hotel near the Manchester Arena following reports of an explosion, in Manchester, Britain EPA Manchester explosion in pictures Police officers are seen outside the Manchester Arena, where U.S. singer Ariana Grande had been performing, in Manchester, northern England Reuters Manchester explosion in pictures MANCHESTER, ENGLAND - MAY 23: Police escort members of the public from the Manchester Arena on May 23, 2017 in Manchester, England. An explosion occurred at Manchester Arena as concert goers were leaving the venue after Ariana Grande had performed. Greater Manchester Police have confirmed 19 fatalities and at least 50 injured. (Photo by Christopher Furlong/Getty Images) Getty Images Manchester explosion in pictures MANCHESTER, ENGLAND - Emergency services arrive close to the Manchester Arena on May 23, 2017 in Manchester, England. There have been reports of explosions at Manchester Arena where Ariana Grande had performed this evening. Greater Manchester Police have have confirmed there are fatalities and warned people to stay away from the area. (Photo by Dave Thompson/Getty Images) Getty Images Manchester explosion in pictures MANCHESTER, ENGLAND - MAY 23: Police escort members of the public from the Manchester Arena on May 23, 2017 in Manchester, England. An explosion occurred at Manchester Arena as concert goers were leaving the venue after Ariana Grande had performed. Greater Manchester Police have confirmed 19 fatalities and at least 50 injured. (Photo by Christopher Furlong/Getty Images) Getty Images Manchester explosion in pictures Medics deploy at the scene of a reported explosion during a concert in Manchester, England on May 23, 2017. British police said early May 23 there were "a number of confirmed fatalities" after reports of at least one explosion during a pop concert by US singer Ariana Grande. Ambulances were seen rushing to the Manchester Arena venue and police added in a statement that people should avoid the area / AFP PHOTO / Paul ELLIS (Photo credit should read PAUL ELLIS/AFP/Getty Images) AFP/Getty Images Manchester explosion in pictures Police and fans close to the Manchester Arena, after reports of an explosion Getty Images Manchester explosion in pictures There have been reports of explosions at Manchester Arena where Ariana Grande had performed Getty Images Manchester explosion in pictures Police deploy at scene of explosion in Manchester, England, at a concert in Manchester Arena AFP/Getty Images Manchester explosion in pictures Police stand by a cordoned off street close to the Manchester Arena Getty Images Manchester explosion in pictures Police deploy at scene of explosion in Manchester, England AFP/Getty Images Manchester explosion in pictures Police deploy at scene of a reported explosion during a concert in Manchester, England, on May 23, 2017. British police said early May 23 there were "a number of confirmed fatalities" after reports of at least one explosion during a pop concert by US singer Ariana Grande. Ambulances were seen rushing to the Manchester Arena venue and police added in a statement that people should avoid the area AFP/Getty Images Manchester explosion in pictures An ambulance drives away from the Manchester Arena, where U.S. singer Ariana Grande had been performing, in Manchester Reuters Manchester explosion in pictures Police escort members of the public from the Manchester Arena in Manchester, England. Getty Images Manchester explosion in pictures A woman sits in the street in a blanket near the Manchester Arena as police guard the area following reports of an explosion, in Manchester, Britain EPA Manchester explosion in pictures Two women wrapped in thermal blankets stand near the Manchester Arena, where US singer Ariana Grande had been performing, in Manchester Reuters Manchester explosion in pictures A Royal Logistic Corps (RLC) bomb disposal robot is unloaded outside the Manchester Arena following reports of an explosion, in Manchester. At least 19 people have been confirmed dead and others 50 were injured, authorities said. It is being treated as a terrorist incident until police know otherwise EPA Manchester explosion in pictures A Royal Logistic Corps (RLC) bomb disposal robot is unloaded outside the Manchester Arena following reports of an explosion, in Manchester EPA Manchester explosion in pictures Members of the public receive treatment from emergency service staff at Victoria Railway Station close to the Manchester Arena on May 23, 2017 in Manchester, England. There have been reports of explosions at Manchester Arena where Ariana Grande had performed this evening. Greater Manchester Police have have confirmed there are fatalities and warned people to stay away from the area Getty Images Manchester explosion in pictures Armed police after a suspected terrorist attack at the Manchester Arena at the end of a concert by US star Ariana Grande left 19 dead PA wire Manchester explosion in pictures Emergency services arrive close to the Manchester Arena in Manchester Getty Images Manchester explosion in pictures An amoured police vehicle patrols near Manchester Arena in Manchester Getty Images Manchester explosion in pictures A man carries a young girl on his shoulders near Victoria station in Manchester AFP/Getty Images Manchester explosion in pictures Police officers stand at the Miller Street and Corporation Street Crossroads, in front of the Manchester Arena in Manchester, England Getty Images Manchester explosion in pictures Police block a road near to the Manchester Arena in central Manchester, England AP Manchester explosion in pictures Armed police patrol near Victoria station in Manchester, northwest England. Twenty two people have been killed and dozens injured after a suspected suicide bomber targeted fans leaving a concert of US singer Ariana Grande in Manchester Getty Images Manchester explosion in pictures Police forensic officers leave the Manchester Arena as they investigate the scene of an explosion in Manchester Getty Images Manchester explosion in pictures A forensic officer collects evidence on a walkway between Victoria station and Manchester Arena following a deadly terror attack in Manchester, Getty Images Manchester explosion in pictures A woman and a young girl wearing a t-shirt of US singer Ariana Grande talks to police near Manchester Arena following a deadly terror attack in Manchester, Getty Manchester explosion in pictures epaselect epa05982725 Susan Walton and daughter Katie, 10 (pictured), who attended the concert of Ariana Grande at the Manchester Arena, are seen in Manchester, Britain, 23 May 2017. According to a statement released by the Greater Manchester Police on 23 May 2017, police responded to reports of an explosion at Manchester Arena on 22 May 2017 evening. At least 19 people have been confirmed dead and around 50 others were injured, authorities said. The happening is currently treated as a terrorist incident until police know otherwise. According to reports quoting witnesses, a mass evacuation was prompted after explosions were heard at the end of US singer Ariana Grande's concert in the arena. EPA/NIGEL RODDIS EPA Manchester explosion in pictures Mayor of Greater Manchester Andy Burnham and Manchester City Council Leader Sir Richard Leese speak to the media outside Manchester Town Hall after a suicide bomber killed 22 people, including children, as an explosion tore through fans leaving a pop concert in Manchester Dave Higgens/PA Wire Manchester explosion in pictures The media gather behind a police cordon in Manchester Getty Images Manchester explosion in pictures Flowers left close to the Manchester Arena, the morning after a suicide bomber killed 22 people, including children, as an explosion tore through fans leaving a pop concert in Manchester Danny Lawson/PA Wire Manchester explosion in pictures Ariana Grande concert attendees Karen Moore and her daughter Molly Steed, aged 14, from Derby, leave the Park Inn where they were given refuge after last night's explosion at Manchester Arena Getty Manchester explosion in pictures Signs saying 'We love Manchester' are displayed in a window in Manchester, England Getty Images

A Government's emergency Cobra committee is expected to take place at around 9am on Tuesday morning chaired by Theresa May, Downing Street said.

The attack is the worst carried out in the UK since 56 people were killed in the 7 July London bombings in 2005.

Victims of the explosion are being treated at eight hospitals across the city of Manchester.