Magiorkinis E.

Sidiropoulou K.

Diamantis A. Hallmarks in the History of Epilepsy: From Antiquity Till the Twentieth Century. in: Foyaca-Sibat P.H. Novel Aspects on Epilepsy. InTech , Rijeka, Croatia : 131-156 View in Article Crossref

Google Scholar

Berg A.T.

Berkovic S.F.

Brodie M.J.

Buchhalter J.

Cross J.H.

van Emde Boas W.

et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 51 : 676-685 View in Article Scopus (1288)

PubMed

Crossref

Google Scholar

Goldenberg M.M. Overview of Drugs Used For Epilepsy and Seizures: Etiology, Diagnosis, and Treatment. Pharm Ther. 35 : 392-415 View in Article Google Scholar

Hauptmann A. Luminal bei Epilepsie. Münchner Med Wochenschr. 59 : 1907-1909 View in Article Google Scholar

Chast F. Chapter 1 - A History of Drug Discovery: From first steps of chemistry to achievements in molecular pharmacology. in: Wermuth C.G. The Practice of Medicinal Chemistry. Third Edition. Academic Press , New York : 1-62 View in Article Scopus (3)

Crossref

Google Scholar

Lee S.K. Old versus New: Why Do We Need New Antiepileptic Drugs?. J Epilepsy Res. 4 : 39-44 View in Article Crossref

Google Scholar

Schmidt D. Is antiepileptogenesis a realistic goal in clinical trials? Concerns and new horizons. Epileptic Disord. 14 : 105-113 View in Article PubMed

Google Scholar

Liu R.

Zhang L.

Lan X.

Li L.

Zhang T.T.

Sun J.H.

et al. Protection by borneol on cortical neurons against oxygen-glucose deprivation/reperfusion: involvement of anti-oxidation and anti-inflammation through nuclear transcription factor kappaappaB signaling pathway. Neuroscience. 176 : 408-419 View in Article Scopus (43)

PubMed

Crossref

Google Scholar

WHO Epilepsy in the WHO Africa region, bridging the gap. The global campaign against epilepsy "Out of the shadows". in: WHO World Health Organization , Geneva View in Article Google Scholar

Mbuba C.K.

Ngugi A.K.

Newton C.R.

Carter J.A. The epilepsy treatment gap in developing countries: A systematic review of the magnitude, causes, and intervention strategies. Epilepsia. 49 : 1491-1503 View in Article Scopus (90)

PubMed

Crossref

Google Scholar

Preux P.M.

Tiemagni F.

Fodzo L.

Kandem P.

Ngouafong P.

Ndonko F.

et al. Antiepileptic therapies in the Mifi Province in Cameroon. Epilepsia. 41 : 432-439 View in Article PubMed

Crossref

Google Scholar

Akah P.A.

Nwambie A.I.

Gamaniel K.S.

Wambebe C. Experimental study of the anticonvulsant plants used for treatment of infantile convulsion in Nigeria. Brain Res Bull. 44 : 611-613 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Adams M.

Schneider S.-V.

Kluge M.

Kessler M.

Hamburger M. Epilepsy in the Renaissance A survey of remedies from 16th and 17th century German herbals. J Ethnopharmacol. 143 : 1-13 View in Article Scopus (16)

PubMed

Crossref

Google Scholar

White H.S.

Smith-Yockman M.

Srivastava A.

Wilcox K.S. Chapter 44 - Therapeutic Assays for the Identification and Characterization of Antiepileptic and Antiepileptogenic Drugs. in: Moshé A.P.A.S.L. Models of Seizures and Epilepsy. Academic Press , Burlington : 539-549 View in Article Scopus (0)

Crossref

Google Scholar

Kasthuri S.

Karthigadevi K.

Manjulakshmi P.

Kavimani S. Medicinal Plants With Anti Convulsant Activity – A Review. Int J Univ Pharm Bio Sci. 2 : 285-296 View in Article Google Scholar

Mittal P.

Kaushik D.

Kaushik P.

Gupta V.

Ghaiye P. Therapeutic efficacy of phytochemicals as anti-epileptic - a review. Pharmacol Online. 1 : 246-271 View in Article Google Scholar

Raza M.

Choudhary M.I.

Atta Ur R. Medicinal Plants With Anticonvulsant Activities. in: Rahman A.-u. Studies in Natural Products Chemistry. : 507-553 View in Article Google Scholar

Rezvani M.E.

Roohbakhsh A.

Allahtavakoli M.

Shamsizadeh A. Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. J Ethnopharmacol. 127 : 313-318 View in Article Scopus (13)

PubMed

Crossref

Google Scholar

Saberi M.

Rezvanizadeh A.

Bakhtiarian A. The antiepileptic activity of Vitex agnus castus extract on amygdala kindled seizures in male rats. Neurosci Lett. 441 : 193-196 View in Article Scopus (7)

PubMed

Crossref

Google Scholar

Ramezani R.

Moghimi A.

Rakhshandeh H.

Ejtehadi H.

Kheirabadi M. The effect of Rosa damascena essential oil on the amygdala electrical kindling seizures in rat. Pak J Biol Sci. 11 : 746-751 View in Article Scopus (7)

PubMed

Crossref

Google Scholar

Gupta Y.K.

Sharma M.

Chaudhary G. Antiepileptic activity of Panax ginseng against pentylenetetrazole induced kindling in rats. Indian J Physiol Pharmacol. 45 : 502-506 View in Article PubMed

Google Scholar

Rahmati B.

Khalili M.

Roghani M.

Ahghari P. Anti-epileptogenic and antioxidant effect of Lavandula officinalis aerial part extract against pentylenetetrazol-induced kindling in male mice. J Ethnopharmacol. 148 : 152-157 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Ivetic V.

Trivic S.

Pogancev M.K.

Popovic M.

Zlinská J. Effects of St John's wort (Hypericum perforatum L.) extracts on epileptogenesis. Molecules. 16 : 8062-8075 View in Article PubMed

Crossref

Google Scholar

Duan F.R.

Yuan B.Q. Effect of extracts of Ginkgo biloba leaf on learning-memory ability and NMDA receptor 1 expression in the hippocampus in rats with kindling-induced epilepsy. Zhongguo Dang Dai Er Ke Za Zhi. 10 : 367-370 View in Article PubMed

Google Scholar

Rezvani M.

Vahidi A.

Esmaili M.

Bagheri S. Anticonvulsant effect of ferula assa-foetida oleo gum resin on chemical and amygdala-kindled rats. N Am J Med Sci. 6 : 408 View in Article PubMed

Crossref

Google Scholar

Kiasalari Z.

Khalili M.

Roghani M.

Sadeghian A. Antiepileptic and Antioxidant Effect of Brassica nigra on Pentylenetetrazol-Induced Kindling in Mice. Iran J Pharm Res. 11 : 1209-1217 View in Article Google Scholar

Arash A.

Mohammad M.-Z.

Jamal M.S.

Mohammad T.A.

Azam A. Effects of the Aqueous Extract of Anethum graveolens Leaves on Seizure Induced by Pentylenetetrazole in Mice. Malays J Med Sci. 20 : 23-30 View in Article PubMed

Google Scholar

Pahuja M.

Mehla J.

Reeta K.H.

Tripathi M.

Gupta Y.K. Effect of Anacyclus pyrethrum on pentylenetetrazole-induced kindling, spatial memory, oxidative stress and rho-kinase II expression in mice. Neurochem Res. 38 : 547-556 View in Article Scopus (4)

PubMed

Crossref

Google Scholar

Rathor N.

Arora T.

Manocha S.

Patil A.N.

Mediratta P.K.

Sharma K.K. Anticonvulsant activity of Aloe veraleaf extract in acute and chronic models of epilepsy in mice. J Pharm Pharmacol. 66 : 477-485 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Jager A.K.

Mohoto S.P.

van Heerden F.R.

Viljoen A.M. Activity of a traditional South African epilepsy remedy in the GABA-benzodiazepine receptor assay. J Ethnopharmacol. 96 : 603-606 View in Article Scopus (12)

PubMed

Crossref

Google Scholar

Risa J.

Risa A.

Adsersen A.

Gauguin B.

Stafford G.I.

Van Staden J.

et al. Screening of plants used in southern Africa for epilepsy and convulsions in the GABAA-benzodiazepine receptor assay. J Ethnopharmacol. 93 : 177-182 View in Article Scopus (41)

PubMed

Crossref

Google Scholar

Golechha M.

Bhatia J.

Arya D.S. Hydroalcoholic extract of Emblica officinalis Gaertn. affords protection against PTZ-induced seizures, oxidative stress and cognitive impairment in rats. Indian J Exp Biol. 48 : 474-478 View in Article PubMed

Google Scholar

Dhingra D.

Joshi P.

Gupta A.

Chhillar R. Possible involvement of monoaminergic neurotransmission in antidepressant-like activity of Emblica officinalis fruits in mice. CNS Neurosci Ther. 18 : 419-425 View in Article Scopus (4)

PubMed

Crossref

Google Scholar

Adeyemi O.O.

Akindele A.J.

Yemitan O.K.

Aigbe F.R.

Fagbo F.I. Anticonvulsant, anxiolytic and sedative activities of the aqueous root extract of Securidaca longepedunculata Fresen. J Ethnopharmacol. 130 : 191-195 View in Article Scopus (14)

PubMed

Crossref

Google Scholar

Jena P.K.

Dinda S.C.

Ellaiah P. Phytochemical investigation and simultaneous study on antipyretic, anticonvulsant activity of different leafy extracts of smilax zeylanica Linn. Orient Pharm Exp Med. 12 : 123-127 View in Article Crossref

Google Scholar

Sugaya A.

Suzuki T.

Sugaya E.

Yuyama N.

Yasuda K.

Tsuda T. Inhibitory effect of peony root extract on pentylenetetrazol-induced EEG power spectrum changes and extracellular calcium concentration changes in rat cerebral cortex. J Ethnopharmacol. 33 : 159-167 View in Article Scopus (40)

PubMed

Crossref

Google Scholar

Tsuda T.

Sugaya A.

Ohguchi H.

Kishida N.

Sugaya E. Protective effects of peony root extract and its components on neuron damage in the hippocampus induced by the cobalt focus epilepsy model. Exp Neurol. 146 : 518-525 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Shankar A.S.

Suneel K.R.

Raghuprasada M.S.

Ramachandra K.

Keerthi Sagar J.

Reshma S.R. Evaluation of anticonvulsant activity of ethanolic extract of Nymphaea alba Linn. (white water Lily) and its comparison with phenytoin sodium and sodium valproate in albino rats. BioMedRx. 1 : 135-139 View in Article Google Scholar

Raza M.

Shaheen F.

Choudhary M.I.

Suria A.

Rahman A.U.

Sombati S.

et al. Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum. Phytother Res. 15 : 426-430 View in Article Scopus (25)

PubMed

Crossref

Google Scholar

Asaduzzaman M.

Uddin M.J.

Kader M.A.

Alam A.H.

Rahman A.A.

Rashid M.

et al. In vitro acetylcholinesterase inhibitory activity and the antioxidant properties of Aegle marmelos leaf extract: implications for the treatment of Alzheimer's disease. Psychogeriatrics. 14 : 1-10 View in Article PubMed

Crossref

Google Scholar

Gopalakrishna H.N.

Sudhakar P.

Shilin G.

Ashok K.S.

Holla G.K.S.

Vinod N.

et al. Effect of acorus Calamus on electrical and chemical induced seizures in mice. Int J Appl Biol Pharm Technol. 1 : 465-473 View in Article Google Scholar

Shukla P.K.

Khanna V.K.

Ali M.M.

Maurya R.

Khan M.Y.

Srimal R.C. Neuroprotective effect of Acorus calamus against middle cerebral artery occlusion-induced ischaemia in rat. Hum Exp Toxicol. 25 : 187-194 View in Article Scopus (30)

PubMed

Crossref

Google Scholar

Navarro Ruíz A.

Bastidas Ramírez B.E.

García Estrada J.

García López P.

Garzón P. Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital. J Ethnopharmacol. 45 : 199-206 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Kumar R.S.

Madhab K.D. An experimental evaluation of anticonvulsant activity of Nerium oleander leaf extract. Int Res J Pharm. 2 : 73-75 View in Article Google Scholar

Tandon V.R.

Gupta R.K. An experimental evaluation of anticonvulsant activity of Vitex-negundo. Indian J Physiol Pharmacol. 49 : 199-205 View in Article PubMed

Google Scholar

Buyukokuroglu M.E.

Demirezer L.O.

Sedative Guvenalp Z. Anticonvulsant and behaviour modifying effects of Centranthus longiflorus ssp. longiflorus: a study of comparison to diazepam. Pharmazie. 57 : 559-561 View in Article PubMed

Google Scholar

Jesupillai M.

Thillai Arasu P.

Jasemine S.

Bharathidhasan P. Evaluation of anti convulsant activity of aerial parts of Phyllanthus longiflorus heyne ex hook. Eur Rev Med Pharmacol Sci. 16 : 28-30 View in Article PubMed

Google Scholar

Bastidas Ramirez B.E.

Navarro Ruiz N.

Quezada Arellano J.D.

Ruiz Madrigal B.

Villanueva Michel M.T.

Garzon P. Anticonvulsant effects of Magnolia grandiflora L. in the rat. J Ethnopharmacol. 61 : 143-152 View in Article PubMed

Crossref

Google Scholar

de Almeida E.R.

Rafael K.R.

Couto G.B.

Ishigami A.B. Anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and alpha-tocopherol presents in the extract of leaves of Cissus sicyoides L. (Vitaceae). J Biomed Biotechnol. 2009 : 274740 View in Article Scopus (17)

PubMed

Crossref

Google Scholar

Cardenas-Rodriguez N.

Gonzalez-Trujano M.E.

Aguirre-Hernandez E.

Ruiz-Garcia M.

Sampieri III, A.

Coballase-Urrutia E.

et al. Anticonvulsant and antioxidant effects of Tilia americana var. mexicana and flavonoids constituents in the pentylenetetrazole-induced seizures. Oxid Med Cell Longev. 2014 View in Article Google Scholar

Nugroho A.

Kim M.-H.

Choi J.

Choi J.S.

Jung W.T.

Lee K.-T.

et al. Phytochemical studies of the phenolic substances in Aster glehni extract and its sedative and anticonvulsant activity. Arch Pharm Res. 35 : 423-430 View in Article Scopus (4)

PubMed

Crossref

Google Scholar

Ishola I.O.

Akindele A.J.

Agbaje E.O.

Ochieng C.O.

Adeyemi O.O. Anticonvulsant effect of methanolic extract and isolation of active constituents from Cnestis ferruginea Vahl ex DC (Connaraceae). West Afr J Pharm. 25 : 9-19 View in Article Google Scholar

Nugroho A.

Lim S.-C.

Choi J.

Park H.-J. Identification and quantification of the sedative and anticonvulsant flavone glycoside from Chrysanthemum boreale. Arch Pharm Res. 36 : 51-60 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Oladoye S.O.

Fakunle C.O.

Adeoye O.A. Isolation and Characterization of an Anticonvulsant Principle from Leaf Extract of Pyrenacantha Staudtii. J Nat Sci Res. 3 : 69-73 View in Article Google Scholar

Dhayabaran D.

Florance E.J.

Nandakumar K.

Shanmugarathinam A.

Puratchikody A. Anticonvulsant activity of fraction isolated from ethanolic extract of heartwood of Cedrus deodara. J Nat Med. 68 : 310-315 View in Article Scopus (1)

Crossref

Google Scholar

Kumar N.

Dhayabaran D.

Nampoothiri M.

Nandakumar K.

Puratchikody A.

Lalani N.

et al. Atypical Antidepressant Activity of 3,4-Bis(3,4-Dimethoxyphenyl) Furan-2,5-Dione Isolated from Heart Wood of Cedrus deodara, in Rodents. Kor J Physiol Pharmacol. 18 : 365-369 View in Article PubMed

Crossref

Google Scholar

Coull J.A.

Gagnon M. The manipulation of cation-chloride co-transporters as a novel means to treat persistent pain, epilepsy and other neurological disorders. Curr Opin Investig Drugs. 10 : 56-61 View in Article PubMed

Google Scholar

Shah M.M.

Huang Z.

Martinello K. HCN and K(V)7 (M-) channels as targets for epilepsy treatment. Neuropharmacology. 69 : 75-81 View in Article PubMed

Crossref

Google Scholar

Zeng C.

Zhou P.

Jiang T.

Yuan C.

Ma Y.

Feng L.

et al. Upregulation and Diverse Roles of TRPC3 and TRPC6 in Synaptic Reorganization of the Mossy Fiber Pathway in Temporal Lobe Epilepsy. Mol Neurobiol. 1–11 View in Article Google Scholar

Shigetomi E.

Tong X.

Kwan K.Y.

Corey D.P.

Khakh B.S. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3. Nat Neurosci. 15 : 70-80 View in Article Scopus (99)

Crossref

Google Scholar

Stölting G.

Fischer M.

Fahlke C. CLC channel function and dysfunction in health and disease. Front Physiol. 5 : 378 View in Article PubMed

Google Scholar

Johnston G.A.

Hanrahan J.R.

Chebib M.

Duke R.K.

Mewett K.N. Modulation of ionotropic GABA receptors by natural products of plant origin. Adv Pharmacol. 54 : 285-316 View in Article PubMed

Crossref

Google Scholar

Roberts S.M.

Bezinover D.S.

Janicki P.K. Reappraisal of the role of dolasetron in prevention and treatment of nausea and vomiting associated with surgery or chemotherapy. Cancer Manag Res. 4 : 67-73 View in Article PubMed

Google Scholar

Medina J.H.

Paladini A.C.

Wolfman C.

Levi de Stein M.

Calvo D.

Diaz L.E.

et al. Chrysin (5,7-di-OH-flavone), a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant properties. Biochem Pharmacol. 40 : 2227-2231 View in Article Scopus (106)

PubMed

Crossref

Google Scholar

Wasowski C.

Marder M. Flavonoids as GABAA receptor ligands: the whole story?. J Exp Pharmacol. 4 : 9-24 View in Article Google Scholar

Liu Y.-F.

Gao F.

Li X.-W.

Jia R.-H.

Meng X.-D.

Zhao R.

et al. The Anticonvulsant and Neuroprotective Effects of Baicalin on Pilocarpine-Induced Epileptic Model in Rats. Neurochem Res. 37 : 1670-1680 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Huen M.S.Y.

Leung J.W.C.

Ng W.

Lui W.S.

Chan M.N.S.

Tze-Fei Wong J.

et al. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol. 66 : 125-132 View in Article Scopus (49)

PubMed

Crossref

Google Scholar

Lin Y.L.

Lin R.J.

Shen K.P.

Dai Z.K.

Chen I.J.

Wu J.R.

et al. Baicalein, isolated from Scutellaria baicalensis, protects against endothelin-1-induced pulmonary artery smooth muscle cell proliferation via inhibition of TRPC1 channel expression. J Ethnopharmacol. 138 : 373-381 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Raygude K.S.

Kandhare A.D.

Ghosh P.

Bodhankar S.L. Anticonvulsant effect of fisetin by modulation of endogenous biomarkers. Biomed Prev Nutr. 2 : 215-222 View in Article Scopus (23)

Crossref

Google Scholar

Carlson A.E.

Rosenbaum J.C.

Brelidze T.I.

Klevit R.E.

Zagotta W.N. Flavonoid Regulation of HCN2 Channels. J Biol Chem. 288 : 33136-33145 View in Article PubMed

Crossref

Google Scholar

Saponara S.

Testai L.

Iozzi D.

Martinotti E.

Martelli A.

Chericoni S.

et al. (+/-)-Naringenin as large conductance Ca(2 +)-activated K + (BKCa) channel opener in vascular smooth muscle cells. Br J Pharmacol. 149 : 1013-1021 View in Article Scopus (38)

PubMed

Crossref

Google Scholar

Liu Y.

Niu L.

Cui L.

Hou X.

Li J.

Zhang X.

et al. Hesperetin inhibits rat coronary constriction by inhibiting Ca(2 +) influx and enhancing voltage-gated K(+) channel currents of the myocytes. Eur J Pharmacol. 735 : 193-201 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Hou X.

Liu Y.

Niu L.

Cui L.

Zhang M. Enhancement of voltage-gated K + channels and depression of voltage-gated Ca2 + channels are involved in quercetin-induced vasorelaxation in rat coronary artery. Planta Med. 80 : 465-472 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Yao Y.

Han D.D.

Zhang T.

Yang Z. Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage-dependent sodium channels in hippocampal CA1 pyramidal neurons. Phytother Res. 24 : 136-140 View in Article Scopus (35)

PubMed

Crossref

Google Scholar

Kim H.J.

Lee B.H.

Choi S.H.

Jung S.W.

Kim H.S.

Lee J.H.

et al. Differential effects of quercetin glycosides on GABAC receptor channel activity. Arch Pharm Res. 38 : 108-114 View in Article PubMed

Crossref

Google Scholar

Lee B.H.

Pyo M.K.

Lee J.H.

Choi S.H.

Shin T.J.

Lee S.M.

et al. Differential regulations of quercetin and its glycosides on ligand-gated ion channels. Biol Pharm Bull. 31 : 611-617 View in Article Scopus (7)

PubMed

Crossref

Google Scholar

Buenafe O.E.

Orellana-Paucar A.

Maes J.

Huang H.

Ying X.

De Borggraeve W.

et al. Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models. ACS Chem Neurosci. 4 : 1479-1487 View in Article Scopus (6)

PubMed

Crossref

Google Scholar

Tan X.-q.

Cheng X.-l.

Yang Y.

Yan L.

Gu J.-l.

Li H.

et al. Tanshinone II-A sodium sulfonate (DS-201) enhances human BK(Ca) channel activity by selectively targeting the pore-forming α subunit. Acta Pharmacol Sin. 35 : 1351-1363 View in Article PubMed

Crossref

Google Scholar

Tan X.

Yang Y.

Cheng J.

Li P.

Inoue I.

Zeng X. Unique action of sodium tanshinone II-A sulfonate (DS-201) on the Ca(2 +) dependent BK(Ca) activation in mouse cerebral arterial smooth muscle cells. Eur J Pharmacol. 656 : 27-32 View in Article Scopus (8)

PubMed

Crossref

Google Scholar

Sun D.D.

Wang H.C.

Wang X.B.

Luo Y.

Jin Z.X.

Li Z.C.

et al. Tanshinone IIA: a new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels. Eur J Pharmacol. 590 : 317-321 View in Article Scopus (33)

PubMed

Crossref

Google Scholar

Lin T.Y.

Lu C.W.

Huang S.K.

Wang S.J. Tanshinone IIA, a constituent of Danshen, inhibits the release of glutamate in rat cerebrocortical nerve terminals. J Ethnopharmacol. 147 : 488-496 View in Article Scopus (5)

PubMed

Crossref

Google Scholar

Lee B.-H.

Kim H.-J.

Chung L.

Nah S.-Y. Ginsenoside Rg3 regulates GABAA receptor channel activity: Involvement of interaction with the γ2 subunit. Eur J Pharmacol. 705 : 119-125 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Choi S.H.

Shin T.J.

Lee B.H.

Chu D.H.

Choe H.

Pyo M.K.

et al. Ginsenoside Rg3 activates human KCNQ1 K + channel currents through interacting with the K318 and V319 residues: a role of KCNE1 subunit. Eur J Pharmacol. 637 : 138-147 View in Article Scopus (15)

PubMed

Crossref

Google Scholar

Lee J.H.

Jeong S.M.

Kim J.H.

Lee B.H.

Yoon I.S.

Lee J.H.

et al. Effects of Ginsenosides and Their Metabolites on Voltage-dependent Ca2 + Channel Subtypes. Mol Cells. 21 : 52-62 View in Article PubMed

Google Scholar

Wu S.-N.

Chen C.-C.

Li H.-F.

Lo Y.-K.

Chen S.-A.

Chiang H.-T. Stimulation of the BKCa channel in cultured smooth muscle cells of human trachea by magnolol. Thorax. 57 : 67-74 View in Article Scopus (32)

PubMed

Crossref

Google Scholar

Ashraf M.N.

Gavrilovici C.

Ali Shah S.U.

Shaheen F.

Choudhary M.I.

Rahman A.-u.

et al. A novel anticonvulsant modulates voltage-gated sodium channel inactivation and prevents kindling-induced seizures. J Neurochem. 126 : 651-661 View in Article PubMed

Crossref

Google Scholar

Lin T.Y.

Lin Y.W.

Lu C.W.

Huang S.K.

Wang S.J. Berberine Inhibits the Release of Glutamate in Nerve Terminals from Rat Cerebral Cortex. PLoS One. 8 : e67215 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Alzamora R.

O'Mahony F.

Ko W.H.

Yip T.W.

Carter D.

Irnaten M.

et al. Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels. Front Physiol. 2 : 33 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Gunthorpe M.J.

Large C.H.

Sankar R. The mechanism of action of retigabine (ezogabine), a first-in-class K + channel opener for the treatment of epilepsy. Epilepsia. 53 : 412-424 View in Article Scopus (63)

PubMed

Crossref

Google Scholar

Bierbower S.M.

Choveau F.S.

Lechleiter J.D.

Shapiro M.S. Augmentation of M-type (KCNQ) potassium channels as a novel strategy to reduce stroke-induced brain injury. J Neurosci. 35 : 2101-2111 View in Article PubMed

Crossref

Google Scholar

Chen H.

Chen Y.

Tang Y.

Yang J.

Wang D.

Yu T.

et al. Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes. Mol Med Rep. 10 : 1576-1582 View in Article PubMed

Crossref

Google Scholar

Wang Z.J.

Levinson S.R.

Sun L.

Heinbockel T. Identification of both GABAA receptors and voltage-activated Na(+) channels as molecular targets of anticonvulsant alpha-asarone. Front Pharmacol. 5 : 40 View in Article PubMed

Google Scholar

Tsai T.Y.

Wu S.N.

Liu Y.C.

Wu A.Z.

Tsai Y.C. Inhibitory action of L -type Ca2 + current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells. Eur J Pharmacol. 523 : 16-24 View in Article Scopus (18)

PubMed

Crossref

Google Scholar

Zhang G.Q.

Hao X.M.

Chen S.Z.

Zhou P.A.

Cheng H.P.

Wu C.H. Blockade of paeoniflorin on sodium current in mouse hippocampal CA1 neurons. Acta Pharmacol Sin. 24 : 1248-1252 View in Article PubMed

Google Scholar

Guo R.B.

Wang G.F.

Zhao A.P.

Gu J.

Sun X.L.

Hu G. Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-kappaB-mediated inflammatory responses. PLoS One. 7 : e49701 View in Article Scopus (32)

PubMed

Crossref

Google Scholar

Qiu F.M.

Zhong X.M.

Mao Q.Q.

Huang Z. Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stress. Neurosci Lett. 541 : 209-213 View in Article Scopus (5)

PubMed

Crossref

Google Scholar

Ohara K.

Fukuda T.

Okada H.

Kitao S.

Ishida Y.

Kato K.

et al. Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil. J Biol Chem. 290 : 3161-3171 View in Article PubMed

Crossref

Google Scholar

Parnas M.

Peters M.

Dadon D.

Lev S.

Vertkin I.

Slutsky I.

et al. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium. 45 : 300-309 View in Article Scopus (55)

PubMed

Crossref

Google Scholar

Cui L.Y.

Zhu Y.C.

Gao S.

Wang J.M.

Peng B.

Ni J.

et al. Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial. Chin Med J (Engl). 126 : 3405-3410 View in Article PubMed

Google Scholar

Ma S.

Xu S.

Liu B.

Li J.

Feng N.

Wang L.

et al. Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats. Naunyn Schmiedebergs Arch Pharmacol. 379 : 565-574 View in Article Scopus (12)

PubMed

Crossref

Google Scholar

Talley E.M.

Solorzano G.

Lei Q.

Kim D.

Bayliss D.A. Cns distribution of members of the two-pore-domain (KCNK) potassium channel family. J Neurosci. 21 : 7491-7505 View in Article PubMed

Google Scholar

Kiss T.

Orvos P.

Bansaghi S.

Forgo P.

Jedlinszki N.

Talosi L.

et al. Identification of diterpene alkaloids from Aconitum napellus subsp. firmum and GIRK channel activities of some Aconitum alkaloids. Fitoterapia. 90 : 85-93 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Borcsa B.

Fodor L.

Csupor D.

Forgo P.

Molnar A.t.

Hohmann J. Diterpene alkaloids from the roots of Aconitum moldavicum and assessment of Nav 1.2 sodium channel activity of aconitum alkaloids. Planta Med. 80 : 231-236 View in Article PubMed

Crossref

Google Scholar

Thurner P.

Stary-Weinzinger A.

Gafar H.

Gawali V.S.

Kudlacek O.

Zezula J.

et al. Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine. J Pharmacol Exp Ther. 348 : 346-358 View in Article PubMed

Crossref

Google Scholar

Koenig X.

Kovar M.

Rubi L.

Mike A.K.

Lukacs P.

Gawali V.S.

et al. Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile. Toxicol Appl Pharmacol. 273 : 259-268 View in Article Scopus (3)

PubMed

Crossref

Google Scholar

Gordon R.K.

Nigam S.V.

Weitz J.A.

Dave J.R.

Doctor B.P.

Ved H.S. The NMDA receptor ion channel: a site for binding of Huperzine A. J Appl Toxicol. 21 : S47-S51 View in Article PubMed

Crossref

Google Scholar

Chen X.

Sun W.

Gianaris N.G.

Riley A.M.

Cummins T.R.

Fehrenbacher J.C.

et al. Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel. J Biol Chem. 289 : 9600-9610 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Iannotti F.A.

Hill C.L.

Leo A.

Alhusaini A.

Soubrane C.

Mazzarella E.

et al. Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chem Neurosci. 5 : 1131-1141 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Lin X.

Chen S.

Tee D. Effects of quinine on the excitability and voltage-dependent currents of isolated spiral ganglion neurons in culture. J Neurophysiol. 79 : 2503-2512 View in Article PubMed

Google Scholar

Bokvist K.

Rorsman P.

Smith P.A. Block of ATP-regulated and Ca2(+)-activated K + channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine. J Physiol. 423 : 327-342 View in Article PubMed

Crossref

Google Scholar

Freedman J.E.

Weight F.F. Quinine potently blocks single K + channels activated by dopamine D-2 receptors in rat corpus striatum neurons. Eur J Pharmacol. 164 : 341-346 View in Article PubMed

Crossref

Google Scholar

Ballestero J.A.

Plazas P.V.

Kracun S.

Gomez-Casati M.E.

Taranda J.

Rothlin C.V.

et al. Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors. Mol Pharmacol. 68 : 822-829 View in Article PubMed

Google Scholar

Voets T.

Droogmans G.

Nilius B. Potent block of volume-activated chloride currents in endothelial cells by the uncharged form of quinine and quinidine. Br J Pharmacol. 118 : 1869-1871 View in Article PubMed

Crossref

Google Scholar

Tricarico D.

Mele A.

Calzolaro S.

Cannone G.

Camerino G.M.

Dinardo M.M.

et al. Emerging role of calcium-activated potassium channel in the regulation of cell viability following potassium ions challenge in HEK293 cells and pharmacological modulation. PLoS One. 8 : e69551 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Da Silva F.H.L.

Gorter J.A.

Wadman W.J. Chapter 3 - Epilepsy as a dynamic disease of neuronal networks. in: Hermann S. William H.T. Handbook of Clinical Neurology. Elsevier , : 35-62 View in Article Google Scholar

Clark A.K.

Gruber-Schoffnegger D.

Drdla-Schutting R.

Gerhold K.J.

Malcangio M.

Sandkuhler J. Selective activation of microglia facilitates synaptic strength. J Neurosci. 35 : 4552-4570 View in Article PubMed

Crossref

Google Scholar

Riazi K.

Galic M.A.

Kentner A.C.

Reid A.Y.

Sharkey K.A.

Pittman Q.J. Microglia-Dependent Alteration of Glutamatergic Synaptic Transmission and Plasticity in the Hippocampus during Peripheral Inflammation. J Neurosci. 35 : 4942-4952 View in Article PubMed

Crossref

Google Scholar

Cao F.L.

Xu M.

Wang Y.

Gong K.R.

Zhang J.T. Tanshinone IIA attenuates neuropathic pain via inhibiting glial activation and immune response. Pharmacol Biochem Behav. 128 : 1-7 View in Article PubMed

Crossref

Google Scholar

Lu J.

Wu D.M.

Zheng Y.L.

Hu B.

Zhang Z.F.

Ye Q.

et al. Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-kappaB pathway activation. Cereb Cortex. 20 : 2540-2548 View in Article Scopus (32)

PubMed

Crossref

Google Scholar

Xiong J.

Wang C.

Chen H.

Hu Y.

Tian L.

Pan J.

et al. Aβ-induced microglial cell activation is inhibited by baicalin through the JAK2/STAT3 signaling pathway. Int J Neurosci. 124 : 609-620 View in Article Scopus (3)

PubMed

Crossref

Google Scholar

Zhong L.M.

Zong Y.

Sun L.

Guo J.Z.

Zhang W.

He Y.

et al. Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PLoS One. 7 : e32195 View in Article Scopus (46)

PubMed

Crossref

Google Scholar

Yeh C.-H.

Shih H.-C.

Hong H.-M.

Lee S.-S.

Yang M.-L.

Chen C.-J.

et al. Protective effect of wogonin on proinflammatory cytokine generation via Jak1/3-STAT1/3 pathway in lipopolysaccharide stimulated BV2 microglial cells. Toxicol Ind Health. ( ) View in Article PubMed

Google Scholar

Lee H.

Kim Y.O.

Kim H.

Kim S.Y.

Noh H.S.

Kang S.S.

et al. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J. 17 : 1943-1944 View in Article PubMed

Google Scholar

Zhu H.T.

Bian C.

Yuan J.C.

Chu W.H.

Xiang X.

Chen F.

et al. Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-kappaB signaling pathway in experimental traumatic brain injury. J Neuroinflammation. 11 : 59 View in Article Scopus (14)

PubMed

Crossref

Google Scholar

Sucher N.

Carles M. Chinese Herbal Medicines for Neuroprotection in Ischemic Stroke: Promise and Reality. in: Wagner H. Ulrich-Merzenich G. Evidence and Rational Based Research on Chinese Drugs. Springer , Vienna : 363-395 View in Article Crossref

Google Scholar

Zhang P.

Hou J.

Fu J.

Li D.

Zhang C.

Liu J. Baicalin protects rat brain microvascular endothelial cells injured by oxygen-glucose deprivation via anti-inflammation. Brain Res Bull. 97 : 8-15 View in Article Scopus (4)

PubMed

Crossref

Google Scholar

Li F.Q.

Wang T.

Pei Z.

Liu B.

Hong J.S. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons. J Neural Transm. 112 : 331-347 View in Article Scopus (78)

PubMed

Crossref

Google Scholar

Xiong Z.

Jiang B.

Wu P.F.

Tian J.

Shi L.L.

Gu J.

et al. Antidepressant effects of a plant-derived flavonoid baicalein involving extracellular signal-regulated kinases cascade. Biol Pharm Bull. 34 : 253-259 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Wang W.

Wang F.

Yang Y.J.

Hu Z.L.

Long L.H.

Fu H.

et al. The flavonoid baicalein promotes NMDA receptor-dependent long-term potentiation and enhances memory. Br J Pharmacol. 162 : 1364-1379 View in Article Scopus (17)

PubMed

Crossref

Google Scholar

Lian Y.-T.

Yang X.-F.

Wang Z.-H.

Yang Y.

Yang Y.

Shu Y.-W.

et al. Curcumin Serves as a Human Kv1.3 Blocker to Inhibit Effector Memory T Lymphocyte Activities. Phytother Res. 27 : 1321-1327 View in Article Scopus (4)

PubMed

Crossref

Google Scholar