Crossbench senator David Leyonhjelm has described Prime Minister Malcolm Turnbull as a "pussy" in a fiery interview.

The Liberal Democratic senator lashed out after Mr Turnbull joined a chorus calling on him to apologise for offensive remarks towards Greens Senator Sarah Hanson-Young .

"This is about misandry," Senator Leyonhjelm told SBS .

"The prime minister should stop being such a pussy. This is about criticism of all men.

"It's just as bad as criticism of all women."

Misandry is the male equivalent of misogyny, a hatred of women.

Senator Leyonhjelm landed in hot water last week after he told Senator Hanson-Young to "stop shagging men" during a debate in the Senate before doubling down with lewd comments about her on Sky News on Sunday.

The cross-bencher has since ignored widespread condemnation and calls for him to apologise and withdraw his remarks.

He claimed that Senator Hanson-Young thinks "all men are responsible for violence against women", which she has denied.

This morning Mr Turnbull became the latest to call on Senator Leyonhjelm to apologise.

"It was clearly offensive, it should have been withdrawn and apologised for. It's not too late for him to do so now," the prime minister said.

Opposition Leader Bill Shorten had a similar opinion.

"Most people in the street actually think what he said was seriously offensive," he said.

"Most people think what you said was stupid. Most people would expect you to apologise."