Sen. Rand Paul Randal (Rand) Howard PaulSecond GOP senator to quarantine after exposure to coronavirus GOP senator to quarantine after coronavirus exposure The Hill's Morning Report - Sponsored by National Industries for the Blind - Trump seeks to flip 'Rage' narrative; Dems block COVID-19 bill MORE (R-Ky.) is facing renewed pressure from President Trump Donald John TrumpOmar fires back at Trump over rally remarks: 'This is my country' Pelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Trump mocks Biden appearance, mask use ahead of first debate MORE and some of his Senate colleagues to support Mike Pompeo Michael (Mike) Richard PompeoOvernight Defense: Pentagon redirects pandemic funding to defense contractors | US planning for full Afghanistan withdrawal by May | Anti-Trump GOP group puts ads in military papers Overnight Defense: House Democrats unveil stopgap spending measure to GOP opposition | Bill includes .6B for new subs | Trump issues Iran sanctions after world shrugs at US action at UN Navalny calls on Russia to return clothes he was wearing when he fell ill MORE for secretary of State as the administration hunts for votes.

Paul’s opposition is complicating Pompeo’s path to confirmation. Republicans are hoping to pass his nomination next week before leaving town for a recess.

Sen. Lindsey Graham Lindsey Olin GrahamSenate GOP aims to confirm Trump court pick by Oct. 29: report The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Senate GOP sees early Supreme Court vote as political booster shot MORE (R-S.C.), who frequently battles with Paul on foreign policy, vented Thursday about Paul’s opposition.

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“I hope that Sen. Paul will reconsider because if he changed his view then this would be over, and it really does bother me,” he said. “He ran for president; I ran for president; Trump beat us both. ... The election is over.”

With Sen. Heidi Heitkamp Mary (Heidi) Kathryn HeitkampCentrists, progressives rally around Harris pick for VP 70 former senators propose bipartisan caucus for incumbents Susan Collins set to play pivotal role in impeachment drama MORE (D-N.D.) becoming the first Democrat to say she will vote for Pompeo on Thursday, Republicans likely won’t need Paul’s support to confirm him on the Senate floor.

But Paul's opposition is poised to make Pompeo the first secretary of State nominee since the mid-1920s — before which committee business was largely conducted in secret — to be moved to the floor despite getting an unfavorable committee vote.

Republicans only hold a one-seat majority on the Senate Foreign Relations Committee.

With Paul, a member of the panel, expected to vote “no” during the committee’s Monday vote, Pompeo would need to pick up the support of at least one Democrat to get majority support.

So far, no Democrat has stepped forward. Sen. Christopher Coons Christopher (Chris) Andrew CoonsMurkowski: Supreme Court nominee should not be taken up before election Battle lines drawn on precedent in Supreme Court fight Sunday shows - Ruth Bader Ginsburg's death dominates MORE (Del.) is the only Democratic member who hasn’t said how he will vote. He previously opposed Pompeo to be CIA director and has said he’s leaning against Pompeo’s current nomination.

President Trump, who has been an ally of Paul's, has upped the pressure on him to support Pompeo.

During a working lunch, Trump said that he has “a lot of confidence” in Paul.

“Rand Paul has never let me down. ... I don’t think he will let us down again,” Trump said.

Winning over Paul, whose foreign policy views often clash with members of his own caucus, might be out of reach even for Trump.

Though Paul met with Pompeo on Thursday, he appeared unmoved after the closed-door powwow.

Sen. Bob Corker Robert (Bob) Phillips CorkerHas Congress captured Russia policy? Tennessee primary battle turns nasty for Republicans Cheney clashes with Trump MORE (R-Tenn.), the chairman of the Foreign Relations Committee, signaled getting Paul on board was unlikely.

“I’ll leave him to the president,” he said while smiling, when asked if Paul could be won over.

Corker then interrupted a reporter who was asking a question on another topic, to turn around and add: “He’s a friend of mine, but I’ll let the president deal with that.”

Sen. Tom Cotton Tom Bryant CottonGOP brushes back charges of hypocrisy in Supreme Court fight Trump uses bin Laden raid to attack Biden Battle lines drawn on precedent in Supreme Court fight MORE (R-Ark.) warned Democrats to support Pompeo and not “conspire” with Paul to block Pompeo’s nomination.

“Sen. Paul has unusual foreign policy views that are not representative of the Republican Senate caucus,” he said to reporters.