An Indiana woman allegedly killed her two young children before stabbing herself in the neck a day after her husband filed for divorce.

Brandi Worley, 30, called 911 at about 4.30am on Thursday and confessed to killing the two children, according to Montgomery County Sheriff Mark Casteel.

'I just stabbed myself and killed my two children,' she is alleged to have told the operator.

Brandi Worley, 30, allegedly killed her two young children before stabbing herself in the neck a day on Thursday at their home in Darlington, Indiana

Officers found seven-year-old Tyler and three-year-old Charlie Worley dead in a bedroom of the family home in Darlington, north-west of Indianapolis.

Their father Jason Worley was asleep in the basement at the time and was unaware of what was happening in the home.

Casteel said the mother of two did not seem to show any remorse during her confession and she seemed 'matter of fact'.

There are no details on how the two young children died.

Worley was taken to IU Health Methodist Hospital to be treated for her self-inflicted stab wounds to her neck. She is yet to be questioned by authorities.

Officers found seven-year-old Tyler and three-year-old Charlie Worley dead in a bedroom of the family home in Darlington, north-west of Indianapolis, on Thursday

The mother of two allegedly called 911 at about 4.30am on Thursday and confessed to killing Tyler and Charlie

Montgomery County Sheriff's deputies remove items from a minivan during the double homicide investigation

There are no details on how the two young children - Tyler and Charlie - died but an autopsy is scheduled for Friday

'We are not used to dealing with things like this,' Casteel told reporters.

'I can't imagine the pain and the grief these families are experiencing this morning,' he said. 'Please keep these families in your thoughts and prayers.'

Authorities said a motive for the attack was unclear and that there was no history of violence at the home.

Court documents show Jason Worley had filed for divorce a day before the children were killed, the Lafayette Journal & Courier reports.

Facebook pages belonging to Jason and Brandi lists their relationship status as separated.

An autopsy on the children's bodies is scheduled for Friday.

The children's father Jason Worley was asleep in the basement at the time and was unaware of what was happening in the home. He is said to have filed for divorce from Brandi this week