Tim Hasselbeck does not believe Austin Ekeler's big Week 1 was a fluke and believes he can be a key contributor for the Chargers. (1:06)

COSTA MESA, Calif. -- Los Angeles Chargers tight end Hunter Henry has once again been bitten by the injury bug, suffering a tibial plateau fracture to his left knee during Sunday's game against the Indianapolis Colts, the team announced Wednesday.

The Chargers expect Henry will miss four to six weeks, a source told ESPN's Adam Schefter. No official timetable has been given for his return, and the team will continue to evaluate the injury.

"He's taking it tough, but he's doing fine," coach Anthony Lynn said. "He wants to be here with his teammates. He wants to play. And not being out there with them, he feels like he's letting them down. But he's not. You can't control these things. You can only control what you can control.

"He'll be back, though. He'll be OK."

Lynn also expressed concern over wide receiver Mike Williams, who suffered a knee injury late in the fourth quarter against the Colts. A source told ESPN's Josina Anderson that Williams is week-to-week with a sore knee, and his status for Sunday's game at the Detroit Lions is uncertain.

Henry suffered the injury when a Colts defender hit him in the legs to bring him down during the second half of the Chargers' 30-24 victory. Henry eventually returned to the game, playing 55 of 59 snaps in Week 1.

The 2016 second-round pick out of Arkansas has battled injuries throughout his career with the Chargers. He missed all of the 2018 regular season with a torn ACL, playing just 14 snaps in the AFC divisional playoff loss to the New England Patriots.

Henry also suffered a lacerated kidney that forced him to miss the final two games of the 2017 season. He also missed a game his rookie season due to a knee injury.

Despite the injuries, Henry leads the Chargers with 12 touchdown receptions since the start of the 2016 season.

"It's obviously disappointing," quarterback Philip Rivers said of Henry's injury. "You hate it for him. You saw how excited he was to be out there this year and how hard he worked to get back. From an offensive standpoint, you saw how big a part of it he is and what it was going to be from last week here as the season gets going."

Lynn said the Chargers will count on backups Virgil Green and Sean Culkin to "step up."

The Chargers worked out former Seattle Seahawks tight end Luke Willson this week; he was most recently released by the Oakland Raiders during final roster cuts. The Chargers also signed tight end Stephen Anderson to the practice squad.

Antonio Gates also remains available and has not ruled out a potential return to the field. The Chargers signed Gates right before the season began in 2018 due to Henry's ACL injury.