Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an emerging technique for the treatment of genital human papillomavirus (HPV)-induced benign and premalignant lesions. We report herein a case series of anogenital CA successfully treated with ALA-PDT and review the literature available to date on this topic. Thirteen out of 14 cases of anogenital condylomata acuminata were successfully treated with topical PDT. We conclude that PDT can be considered a highly effective and safe treatment option for anogenital condylomata acuminata. Also, considering the available literature, the best results are likely to be achieved with a 16–20% gel formulation of 5-ALA and a red light dose of 100–150 J/cm2.