Graffiti “artists” are taking vandalism to new heights — flying drones to mar some of the Big Apple’s tallest and most expensive billboards.

Local tagger KATSU used the high-tech gadget to spray-paint a six-story Calvin Klein billboard featuring model Kendall Jenner in Soho Wednesday night, a ­bizarre video reveals.

To launch the aerosol attack, he attached a can of red spray paint to a drone and blasted the image of Jenner’s face via at Houston and Lafayette streets via remote control, he told Wired magazine.

“It was a bit tense. It turned out surprisingly well. It’s exciting to see its first potential use as a device for vandalism,” an unrepentant KATSU, who also creates art on canvas, told the magazine.

Graffiti drones give vandals easy — and illegal — access to targets once nearly impossible to reach without climbing or rappelling, he said.

But if drone-tagging catches on, it could mean more expensive vandalism cleanup costs — for “art” that nobody seems to understand, critics said Thursday.

“It looks like a mistake. It doesn’t seem like [KATSU] has a lot of experience. He messed up the billboard. Calvin Klein paid a lot of money to put it up there. I don’t think it’s a good idea,” said Alex Krechko, 25, a Brooklyn physical therapy assistant, looking up at the sloppy streaks.

The Soho billboard is one of the city’s biggest and best-known. A few months ago, it featured an image of a shirtless Justin Bieber wearing Calvin Klein tighty whities.

That image was tagged in yellow spray paint, according to an employee at the nearby Happy Paws pet shop.

Cops said they were aware of the graffiti but wouldn’t immediately reveal if they were planning to take action against the admitted vandal.

KATSU is gearing up to release a more “user-friendly” version of the graffiti drone, he told Wired.

A rep for Calvin Klein didn’t respond to a request for comment Thursday.

KATSU created “drone-painting” canvases featured in a Silicon Valley art show last year.