Islamabad, Pakistan (CNN) -- At least 15 people died and more than 100 were injured in a suicide car bomb attack on a police facility in the Pakistani city of Karachi, police said Thursday.

Pakistani Taliban spokesman Azam Tariq told CNN that the Taliban carried out the attack, which police say targeted building that housed a Crime Investigation Department facility.

"We will continue such attacks as long as military operations continue against us," Tariq said. Pakistani security forces have been battling the group in the country's tribal region, which borders Afghanistan.

The blast occurred in a high-security area, near government buildings and major hotels, such as the Pearl Continental and the Sheraton. The U.S. consulate is in the general vicinity but was not considered the target.

U.S. State Department spokesman P.J. Crowley said U.S. consulate operations were not affected and officials are not aware of any U.S. casualties.

A Pakistani government official told CNN that about five gunmen on foot cleared the way for the suicide car bomber by firing on security personnel manning a security check post.

The official said that once the vehicle cleared the check post it raced toward the police facility and rammed into the building.

The official, who asked not to be named because he is not authorized to speak to the media, doesn't know the whereabouts of the gunmen.

Local TV showed footage of a three- or four-story building with significant damage and ambulances rushing the injured from the scene.