Individual acupressure points linked to specific centers in the brain can offer targeted relief for breast cancer patients with persistent fatigue, according to a new neuroimaging study.

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Researchers at the University of Michigan recently examined the effect of two types of acupressure on fatigue in breast cancer survivors using MRI, the first such study of its kind. The results are published in Frontiers in Neurology.

For many breast cancer patients, treatment and recovery is only the beginning of their cancer journey: Up to one-third of women experience fatigue, sometimes debilitating, for years after treatment ends — a side effect that can impair quality of life, relationships and employment.

Although fatigue is a common symptom with few effective solutions, a 2016 study on the use of acupressure for fatigued breast cancer survivors showed promise. Two-thirds of women achieved normal levels of fatigue after learning to self-administer relaxing acupressure.

Those findings helped inspire the latest research.

“We wanted to see whether different types of acupressure worked differently in the brain,” says study author Suzanna Zick, N.D., MPH, associate research professor of family medicine at Michigan Medicine. “What is intriguing about this manuscript is that it shows that the two types of acupressure — stimulating and relaxing — do appear to work via different mechanisms within the brain despite the fact that they both reduced fatigue.”

Researchers chose 19 female breast cancer survivors from the Michigan Tumor Registry who had participated in the prior acupressure study at U-M. For this double-blind, randomized trial, nine patients were taught how to self-administer relaxing acupressure (which is traditionally used to treat insomnia), and 10 were taught how to administer stimulating acupressure (which is used to increase energy).

MRI scans were performed at baseline and at the conclusion of the six-week treatment.

“What we were looking at is the connection between the brainstem — a region important in humans and primates that regulates sleep and alertness — and the default mode network, a network of brain regions that is activated when you’re thinking about your internal state,” says co-author Richard E. Harris, Ph.D., associate professor at the Chronic Pain and Fatigue Research Center at the University of Michigan.

“Previous research has shown that the way these networks connect and interact are very important in the creation of feelings of fatigue, depression and pain.”