KARACHI, Pakistan — A devastating explosion ripped through a crowded market in the western city of Quetta on Saturday, killing at least 63 people and wounding at least 180, the police said.

The attack occurred in a neighborhood dominated by Hazaras, a Shiite ethnic minority that has suffered numerous attacks at the hands of Sunni militant death squads in recent years.

A previous attack on Jan. 10, when a Sunni group bombed a snooker hall in Quetta, killed almost 100 Hazaras, prompting domestic and international outrage.

The police said that Saturday’s bomb was apparently set off by a remote-controlled device, possibly hidden in a rickshaw. The explosion caused a building to collapse and the death toll to rise sharply.