Actress Doris Roberts, the beloved star of "Everybody Loves Raymond" has died, her family confirms. She was 90.

Roberts was a five-time Emmy Award winner with a career that spanned six decades. She died in her sleep Sunday in Los Angeles of natural causes, a statement from her family said.

Roberts' acting career began in 1952 with a role on the TV series "Studio One." She appeared in episodes of "The Naked City," "Ben Casey," and "The Defenders." In 1961, she made her film debut in "Something Wild."

Get Breaking News Delivered to Your Inbox

But she was perhaps best known for her role as Marie Barone on the hit CBS series "Everybody Loves Raymond." Marie played the opinionated and manipulative, yet lovable, mother of Ray.

"We're deeply saddened to learn of the passing of Doris Roberts," CBS said in a statement. "She was a gifted and talented actress who was beloved by audiences that saw her on every screen and stage...we were so privileged to have her call CBS home for so many years. She will be greatly missed. Truly, Everybody Loved Doris."

The creator of "Everybody Loves Raymond" took to Twitter to remember the actress. Phil Rosenthal called her a "wonderful, funny, indelible actress and friend."

We loved our mom, the great #DorisRoberts. A wonderful, funny, indelible actress and friend. pic.twitter.com/539JOa8EWo — Phil Rosenthal (@PhilRosenthal) April 18, 2016

As news of her death spread, other fellow "Everybody Love's Raymond" stars took to Twitter, too.

To my beloved Marie - RIP. pic.twitter.com/TtZCySQnLK — Patricia Heaton (@PatriciaHeaton) April 18, 2016

❤️keep them safe for me up there pic.twitter.com/TkM9K7Xa1P — Madylin Sweeten (@REALAllyBarone) April 19, 2016

For her work on the series, she was nominated for seven Emmy Awards for Outstanding Supporting Actress in a Comedy Series. She won four times for the series.

She previously won an Emmy for a guest appearance on "St. Elsewhere" and was nominated for an Emmy for Outstanding Supporting Actress in a Miniseries or a Movie for the American Playhouse production of "The Sunset Gang."

Her movie career also included roles in: "Barefoot In The Park," "A Lovely Way to Die," "Little Murders," "A New Leaf," "The Taking of Pelham One Two Three," "The Rose," "National Lampoon's Christmas Vacation," "Grandma's Boy," "Aliens in the Attic," and "Madea's Witness Protection."

Roberts has one son, Michael Cannata, Jr., from her first marriage and three grandchildren.

She was born November 4, 1925, in St. Louis Missouri. She grew up in New York.

Tributes to the actress from celebrities and fans began pouring in on social media.

#RIP to one of my ultimate favorites, Doris Roberts. We spoke at length about ageism in Hollywod & I'm proud to say I think she overcame it. — Jackée Harry (@JackeeHarry) April 18, 2016

So sad to read about the passing of Doris Roberts. She will always Marie Barone to me. RIP. — Marlee Matlin (@MarleeMatlin) April 18, 2016

Rest in peace, Doris. You were a good kisser and a great actress. https://t.co/0djotNws2F — Brant Daugherty (@brantdaugherty) April 18, 2016

Very sad news about #DorisRoberts she was just like my mum in Everybody Loves Raymond #RIP — Stephen O'Neil (@PrinceOfHumbug) April 18, 2016

Sorry dear friend Doris Roberts has passed, always wanted our best. Those classes & dinners we shared remain always. pic.twitter.com/GNIeicZBsq — Thaao Penghlis (@ThaaoPenghlis) April 18, 2016

RIP @doris_roberts - you were a dream to work with. Such beauty, so funny and so charming. @bobsaget @JohnStamos pic.twitter.com/dFqmq7KuLL — Dave Coulier (@DaveCoulier) April 19, 2016

TMZ was the first to break the news.