Tackling unemployment will be a major policy the Greens spruik in their quest to unseat Labor in the inner city seat of Wills at the federal election.

It will be one of the first times the party campaign has put such a strong emphasis on employment with the seat's northern suburbs hit hard be the decline in manufacturing.

Greens candidate for Wills Samantha Ratnam with party leader Richard Di Natale. Credit:Simon O'Dwyer

Leading the charge will be Moreland mayor Samantha Ratnam​ who has been endorsed as the Greens' candidate.

Despite a brief flirt with independent Phil Cleary after Bob Hawke left Parliament, Wills has long been a Labor stronghold, but there is a growing threat from the Greens.