Gene Amdahl, a trailblazer in the design of IBM’s mainframe computers, which became the central nervous system for businesses large and small throughout the world, died on Tuesday at a nursing home in Palo Alto, Calif. He was 92.

His wife, Marian, said the cause was pneumonia. He had been treated for Alzheimer’s disease for about five years, she said.

Dr. Amdahl rose from South Dakota farm country, where he attended a one-room school without electricity, to become the epitome of a generation of computer pioneers who combined intellectual brilliance, managerial skill and entrepreneurial vigor to fuel the early growth of the industry.

As a young computer scientist at International Business Machines Corporation in the early 1960s, he played a crucial role in the development of the System/360 series, the most successful line of mainframe computers in IBM’s history. Its architecture influenced computer design for years to come.