The fashion world’s endless game of musical chairs doesn’t stop even for a pandemic. On Friday, Givenchy announced that Clare Waight Keller, the brand’s first female artistic director and a designer who rose to global fame as the creator of Meghan Markle’s wedding dress, was leaving the house after only three years. A successor has not yet been named.

“As the first woman to be the artistic director of this legendary maison, I feel honored to have been given the opportunity to cherish its legacy and bring it new life,” Ms. Waight Keller said in a statement, paying tribute to “the unsung heroes and heroines behind the scenes, for their contribution from product to communications and retail, and every global team member, partner and supplier in between.”

The news completes a shift in the executive suite at Givenchy, which is owned by LVMH Moët Hennessy Louis Vuitton, the world’s largest luxury goods company by sales. On March 6, Renaud de Lesquen was named chief executive, replacing Philippe Fortunato. Mr. de Lesquen started his tenure April 1.

The fall 2020 collection that was shown at Paris Fashion Week in March will be Ms. Waight Keller’s final one for the house, the company statement said.