Comedian Phyllis Diller, known for her self-deprecating humor, died "peacefully in her sleep" at her Los Angeles home Monday morning, her manager told CNN. Diller was 95.

"Her son, Perry, found her with a smile on her face," Milt Suchin said.

Diller , who paved the way for female comedians, began her legendary stand-up comedy career at the age of 37.

"We lost a comedy legend today," comedian Ellen DeGeneres tweeted. "Phyllis Diller was the queen of the one-liners. She was a pioneer."

Diller's career as a stand-up comic skyrocketed in the 1960s, partly because of her many appearances with Bob Hope on his television specials and USO tours. Diller remained good friends with Hope until his death.

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She became a pop culture icon for her disparaging jokes about her looks, her cooking and her husband "Fang."

"She was a true pioneer," said talent agent Fred Wostbrock. "She was the first lady of stand-up comedy. She paved the way for everybody. She paved the way for Joan Rivers, Chelsea Handler, Roseanne Barr, Ellen Degeneres, and all the women stand-up comics. She was the first and the best."

Comedian Whoopi Goldberg tweeted that she was said the world lost a funny, classy and smart woman like Diller.

"A true original has died," Goldberg tweeted, adding that there was nobody who looked or sounded like her.

Diller's first appearance on TV was as a contestant on Groucho Marx's show "You Bet Your Life."

Diller was also known her for hilarious roasts of major personalities. You can watch her roast Ronald Reagan here:

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EW.com: 'She was a true pioneer'