Scott Gleeson

USA TODAY Sports

Pittsburgh's Chris Blewitt drilled a 48-yard game-winning field goal with six seconds left to lift the Panthers past No. 2 Clemson, 43-42, in perhaps the biggest upset of the season.

Clemson had won 21 consecutive home games at Memorial Stadium — the longest streak in the FBS before Saturday's stunning loss — which will likely affect the Tigers' Playoff positioning where they were No. 2 last week. Clemson also had won 46 games in a row against unranked opponents, the second-longest active streak in the FBS behind Alabama's 64.

Heisman contending quarterback Deshaun Watson threw for an ACC record 580 yards on 52 for 70 passing with three touchdowns. But his third interception gave Pitt the chance to crawl back from a 42-34 deficit. After Saleem Brightwell's pick and 70-yard return, Pitt running back James Conner finished the drive with a 20-yard TD run.

Conner ran for 132 yards to carry the Panthers offensively. The Pittsburgh defense, which gave up 630 yards, rose up when it counted and stopped Wayne Gallman short on third and fourth down to take the ball with 58 seconds left. Two passes to Scott Orndoff put Pitt within range and Blewitt nailed the kick to send the Panthers into a frenzy.

Contributing: The Associates Press

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