Irbil, Iraq (CNN) Twelve residents of the war-torn Iraqi city of Mosul were treated for injuries from a suspected chemical attack this week, an official with the International Committee of the Red Cross said.

The patients, who are being treated in hospital in nearby Irbil, are "showing clinical symptoms consistent with an exposure to a blistering chemical agent," said Robert Mardini, the organization's regional director for the Middle East.

The five children, three women and four men have symptoms that include blisters, coughing, redness in the eyes, irritation, and vomiting.

"The use of chemical weapons is absolutely prohibited under international humanitarian law. We are deeply alarmed by what our colleagues have seen, and we strongly condemn any use of chemical weapons, by any party, anywhere," ICRC's Mardini said.

The Organization for the Prohibition of Chemical Weapons released a similar statement on Sunday, stating that it's "seriously concerned" over the alleged use of chemical weapons in Mosul.

"Parties to the Chemical Weapons Convention deem the use of chemical weapons by anyone under any circumstances as reprehensible and wholly contrary to the legal norms established by the international community," the organization said.

Dr. Lawan Miwan, head of Emergency Hospital in Irbil, told CNN his hospital is treating two cases with symptoms consistent with exposure to a toxic chemical agent.

CNN talked with two residents of east Mosul who reported smelling "something strange," "like a chemical agent," or "mustard gas" following mortar attacks on eastern Mosul on Wednesday and Thursday. The residents said the attacks came across the Tigris River from western Mosul.

ICRC spokeswoman Sara Alzawqari said the first three cases were brought to the hospital on Wednesday, followed by another four Thursday. Five victims arrived in somewhat better medical condition on Friday. All are victims of the same attack, Alzawqari said.

The World Health Organization has responded to the reported use of chemical weapons agents in eastern Mosul, activating an emergency response plan to treat those who may be exposed to the highly toxic chemicals, the WHO said Friday.

Two Iraqi security officials near Mosul could not confirm nor deny the incidents to CNN.

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ISIS has used chemical weapons on numerous occasions in Iraq and Syria, including in the battlefield in northern Iraq, according to Iraqi and US officials.

This is believed to be the first such attack in Mosul since the October start of the offensive to retake Iraq's second most populous city from ISIS control .

Iraq: Coalition strike kills 6 ISIS leaders

Six ISIS military leaders were killed during a US-led coalition airstrike in western Mosul, the Iraqi Joint Operations Command said.

Photos: Mosul: Iraqi-led forces push into key city Photos: Mosul: Iraqi-led forces push into key city Members of the Iraqi federal police wave the country's flag as they celebrate in the Old City of Mosul on July 9, 2017. Iraq declared victory against ISIS forces in Mosul after a grueling monthslong campaign. The battle to reclaim Mosul, the last major ISIS stronghold in Iraq, has been underway since fall 2016. Hide Caption 1 of 73 Photos: Mosul: Iraqi-led forces push into key city This injured girl was found by Iraqi forces as they advanced against ISIS militants in the Old City of Mosul on Monday, July 3. She was carried away for medical assistance. Hide Caption 2 of 73 Photos: Mosul: Iraqi-led forces push into key city A suspected ISIS fighter is held in a basement while Iraqi forces continue to push for control of the Old City of Mosul on Monday, July 3. Hide Caption 3 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi Special Forces soldier exchanges fire with ISIS militants in the Old City on Friday, June 30. Hide Caption 4 of 73 Photos: Mosul: Iraqi-led forces push into key city A bomb explodes near the al-Nuri mosque complex on Thursday, June 29. Iraq's military has seized the remains of the Great Mosque of al-Nuri. Iraq and the United States have accused ISIS of blowing up the historic mosque. Hide Caption 5 of 73 Photos: Mosul: Iraqi-led forces push into key city Members of the Iraqi Federal Police hold a position as US-led coalition forces advance through the Old City on Wednesday, June 28. Hide Caption 6 of 73 Photos: Mosul: Iraqi-led forces push into key city The remnants of Mosul's ancient leaning minaret are seen in the Old City on Sunday, June 25. ISIS' claim that US warplanes were responsible for the destruction of the minaret is "1,000% false," US officials told CNN. Hide Caption 7 of 73 Photos: Mosul: Iraqi-led forces push into key city Two boys comfort each other after their home collapsed during fighting between Iraqi forces and militants in Mosul on Saturday, June 24. The boys, who are cousins, said some of their relatives were still under the rubble. Hide Caption 8 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi soldier helps transport a girl as residents flee their homes west of Mosul on Friday, May 26. Hide Caption 9 of 73 Photos: Mosul: Iraqi-led forces push into key city Displaced Iraqis make their way through rubble after evacuating their homes in a neighborhood of west Mosul on Wednesday, May 17. Hide Caption 10 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi man tries to extinguish a burning car during fighting in Mosul's western Rifai neighborhood on Tuesday, May 16. Hide Caption 11 of 73 Photos: Mosul: Iraqi-led forces push into key city A member of the Iraqi counterterrorism service secures a building as troops push toward Mosul's Al-Oraibi western district on Sunday, May 14. Hide Caption 12 of 73 Photos: Mosul: Iraqi-led forces push into key city A smoke cloud rises on the front line as the Iraqi Emergency Response Division advances in west Mosul on Saturday, May 6. Hide Caption 13 of 73 Photos: Mosul: Iraqi-led forces push into key city A wounded man is transported in western Mosul on Friday, April 21. Hide Caption 14 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi federal policeman smokes during a break from battle on Wednesday, April 12. Hide Caption 15 of 73 Photos: Mosul: Iraqi-led forces push into key city A member of Iraq's security forces stands guard in eastern Mosul as smoke rises from the ISIS-controlled western section of the city on Friday, April 7. Hide Caption 16 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqis visit a bath house on the southern outskirts of Mosul on Wednesday, April 5. Hide Caption 17 of 73 Photos: Mosul: Iraqi-led forces push into key city Flames billow from an explosion in Mosul during a clash between Iraqi forces and ISIS fighters on Sunday, March 5. Hide Caption 18 of 73 Photos: Mosul: Iraqi-led forces push into key city Families are forced to evacuate as Iraqi forces advance in western Mosul on Thursday, March 2. The number of internally displaced people has surged as the offensive effort has intensified. Hide Caption 19 of 73 Photos: Mosul: Iraqi-led forces push into key city Mosul residents cross a damaged bridge in the al-Sukkar neighborhood on Saturday, January 21. Hide Caption 20 of 73 Photos: Mosul: Iraqi-led forces push into key city French President Francois Hollande and French Defense Minister Jean-Yves Le Drian, right, view territory held by ISIS during a visit to a military outpost near Mosul on Monday, January 2. Hide Caption 21 of 73 Photos: Mosul: Iraqi-led forces push into key city A young girl takes part in a Christmas Day Mass at a church in the predominantly Christian town of Qaraqosh. The area's churches were heavily damaged by ISIS militants before the town was freed by Iraqi forces during the Mosul offensive. Hide Caption 22 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi Shiite fighters ride through a desert area near the village of Al-Boutha al-Sharqiyah, west of Mosul, on Friday, December 2. Hide Caption 23 of 73 Photos: Mosul: Iraqi-led forces push into key city Internally displaced Iraqis who fled the fighting in Mosul watch as a civilian drone films them at the al-Khazir camp on Thursday, December 1. Hide Caption 24 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi soldier searches a home for ISIS militants after Iraqi forces retook the village of Al-Qasr on Wednesday, November 30. Hide Caption 25 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi soldiers transport a comrade who was injured during a battle near the village of Haj Ali on Tuesday, November 29. Hide Caption 26 of 73 Photos: Mosul: Iraqi-led forces push into key city A man mourns during the funeral of four Iraqi paramilitary fighters who were killed in battles in the town of Tal Afar. Hide Caption 27 of 73 Photos: Mosul: Iraqi-led forces push into key city Displaced civilians return to the village of Tall Abtah on Friday, November 25, after Iraqi forces retook the village from ISIS. Hide Caption 28 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi civilians sit on the ground in Mosul on November 24. An Iraqi officer addressed the group, demanding to know the whereabouts of alleged ISIS militants who opened fire on troops a few days earlier. Hide Caption 29 of 73 Photos: Mosul: Iraqi-led forces push into key city An injured baby receives treatment at a field hospital in Mosul on November 15. Hide Caption 30 of 73 Photos: Mosul: Iraqi-led forces push into key city A woman cries Sunday, November 13, after seeing the St. Addai church that was damaged by ISIS fighters during their occupation of the Keramlis village. Hide Caption 31 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi special forces soldier prays next to a Humvee before troops pushed toward Mosul's Karkukli neighborhood on November 13. Hide Caption 32 of 73 Photos: Mosul: Iraqi-led forces push into key city A Kurdish Peshmerga fighter holds part of a defused bomb planted by ISIS militants in Bashiqa, Iraq, on Friday, November 11. Hide Caption 33 of 73 Photos: Mosul: Iraqi-led forces push into key city A member of Iraq's special forces guards two suspected ISIS fighters found hiding in a house in Mosul on November 11. Hide Caption 34 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi woman displaced by war holds her cat near a checkpoint in the Iraqi village of Shaqouli, east of Mosul, on November 10. Hide Caption 35 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi troops watch a broadcast of Donald Trump's acceptance speech in a house in Arbid, on the outskirts of Mosul, on Wednesday, November 9. Iraqi Prime Minister Haider al-Abadi congratulated Trump on his win and said he hoped for continued support in the war on ISIS. Hide Caption 36 of 73 Photos: Mosul: Iraqi-led forces push into key city US Marines install equipment at a coalition base in Qayyara on November 9. Hide Caption 37 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi forces member investigates a mass grave that was discovered after coalition forces recaptured the area of Hamam al-Alil on Monday, November 7. Hide Caption 38 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi children witness a man being interrogated by a member of the Iraqi army at a base next to the Al-Intissar neighborhood of Mosul on November 7. Hide Caption 39 of 73 Photos: Mosul: Iraqi-led forces push into key city A civilian man who fled the fighting trims his beard after reaching an Iraqi army position in Mosul on November 7. Hide Caption 40 of 73 Photos: Mosul: Iraqi-led forces push into key city Children play in debris created by an airstrike in Qayyara on Sunday, November 6. Hide Caption 41 of 73 Photos: Mosul: Iraqi-led forces push into key city Female members of the Freedom Party of Kurdistan sing as they hold a position near Bashiqa on November 6. Hide Caption 42 of 73 Photos: Mosul: Iraqi-led forces push into key city A baby is passed through a fence back to his mother at a refugee camp in the Khazir region on Saturday, November 5. Hide Caption 43 of 73 Photos: Mosul: Iraqi-led forces push into key city People line up to receive food at a refugee camp in the Khazir region on November 5. Thousands are taking refuge in camps set up for internally displaced people. Hide Caption 44 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi soldiers pass near a bridge destroyed in an airstrike in Qayyara on November 5. Hide Caption 45 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi soldiers patrol an alley on the outskirts of Mosul on Friday, November 4. Hide Caption 46 of 73 Photos: Mosul: Iraqi-led forces push into key city A suspected member of ISIS is detained at a checkpoint near Bartella, Iraq, on November 4. Hide Caption 47 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi families pack into a truck to be moved to camps on Thursday, November 3. Hide Caption 48 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi special forces soldier searches for the location of an ISIS sniper in Gogjali on November 1. Hide Caption 49 of 73 Photos: Mosul: Iraqi-led forces push into key city A man fleeing the village of Bazwaya carries a white flag as he arrives at a checkpoint on November 1. Hide Caption 50 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi soldier receives treatment after being injured during clashes with ISIS fighters near Bazwaya on October 31. Hide Caption 51 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi soldier navigates through a shattered windshield as coalition forces advance on Bazwaya on October 31. Hide Caption 52 of 73 Photos: Mosul: Iraqi-led forces push into key city Archbishop Yohanna Petros Mouche, center, performs Mass in the liberated town of Qaraqosh on Sunday, October 30. Hide Caption 53 of 73 Photos: Mosul: Iraqi-led forces push into key city Children play in a camp for internally displaced people near Kirkuk, Iraq, on October 30. More than 600 families from Tel Afar, a town west of Mosul, have been living in the camp since ISIS took control of the area in 2014. Hide Caption 54 of 73 Photos: Mosul: Iraqi-led forces push into key city Displaced families are seen on the road near Qayyara on Saturday, October 29. Hide Caption 55 of 73 Photos: Mosul: Iraqi-led forces push into key city U.S. military personnel take cover in a bunker after a mortar alarm was sounded at a coalition air base in Qayyara on Friday, October 28. Hide Caption 56 of 73 Photos: Mosul: Iraqi-led forces push into key city Women and children grieve over the grave of a family member at a Qayyara cemetery damaged by ISIS on October 27. Hide Caption 57 of 73 Photos: Mosul: Iraqi-led forces push into key city Residents of Qayyara wait for distribution of food and water rations on October 26. Local water sources have been contaminated by the burning oil and sulfur. Hide Caption 58 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraq's counterterrorism forces advance toward ISIS positions in Tob Zawa on October 25. Hide Caption 59 of 73 Photos: Mosul: Iraqi-led forces push into key city Soldiers give first aid to an injured boy in Tob Zawa on October 25. Hide Caption 60 of 73 Photos: Mosul: Iraqi-led forces push into key city Kurdish Peshmerga forces take positions as they start to move toward the Imam Reza and Tizxirab villages of the Bashiqa district on Sunday, October 23. Hide Caption 61 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi forces distribute fruit in the village of al-Khuwayn, south of Mosul, after recapturing it from ISIS on October 23. Hide Caption 62 of 73 Photos: Mosul: Iraqi-led forces push into key city Kurdish security forces detain a suspected member of ISIS in the eastern suburbs of Kirkuk on Saturday, October 22. Hide Caption 63 of 73 Photos: Mosul: Iraqi-led forces push into key city An Iraqi forces member helps a man push a car as they arrive at a refugee camp in Qayyara on October 22. Hide Caption 64 of 73 Photos: Mosul: Iraqi-led forces push into key city Spent bullet cartridges litter the street around the Jihad Hotel, where ISIS militants battled Iraqi security forces in Kirkuk on Friday, October 21. Hide Caption 65 of 73 Photos: Mosul: Iraqi-led forces push into key city Gen. Abdel Ghani al-Asadi, who leads Iraq's counterterrorism forces, sits in Bartella on October 21 after the town was reclaimed. Hide Caption 66 of 73 Photos: Mosul: Iraqi-led forces push into key city Peshmerga fighters look over a village during an assault near Bashiqa on Thursday, October 20. Hide Caption 67 of 73 Photos: Mosul: Iraqi-led forces push into key city Iraqi forces head toward the front lines near Qayyara on Tuesday, October 18. Hide Caption 68 of 73 Photos: Mosul: Iraqi-led forces push into key city A Peshmerga fighter peers up from an underground tunnel in the liberated town of Badana on October 18. ISIS fighters have built tunnels below residential streets to escape from airstrikes. Hide Caption 69 of 73 Photos: Mosul: Iraqi-led forces push into key city Kurdish security forces take up a position near ISIS-controlled villages on Monday, October 17. Hide Caption 70 of 73 Photos: Mosul: Iraqi-led forces push into key city Smoke rises from a suicide car bomb attack carried out by ISIS in the village of Bedene on October 17. Hide Caption 71 of 73 Photos: Mosul: Iraqi-led forces push into key city Members of the Iraqi coalition gather around a fire at Zardak mountain ahead of the offensive. Hide Caption 72 of 73 Photos: Mosul: Iraqi-led forces push into key city Peshmerga forces deploy in the dark near the village of Wardak early on October 17. Hide Caption 73 of 73

Coalition aircraft destroyed an ISIS headquarters that was a command center for the so-called "Soldiers of the Caliphate."

Abdul Rahman al-Ansari, a Saudi Arabian and the leader of the Soldiers of the Caliphate is among those believed dead, the command center said.

Another airstrike killed the man who led ISIS's booby-trapping operations in Ninevah province, authorities said.

Refugee crisis grows

The number of Iraqi refugees fleeing western Mosul shot up to more than 46,000 by Friday morning, the Ministry of Migration and Displaced in Iraq said.

Photos: Fearful residents flee western Mosul A woman from western Mosul carries her child and the few possessions she could gather before escaping the city. By Saturday, the Iraqi government estimated that nearly 50,000 people had fled western Mosul to government-controlled territory. Most ended up in refugee camps hastily set up by the government and local and international relief groups. Hide Caption 1 of 8 Photos: Fearful residents flee western Mosul An Iraqi man carries his daughter, wounded by a mortar round that slammed into their home in the Ma'moun neighborhood of Mosul. Many of those fleeing were said to have been held as human shields by ISIS fighters while their neighborhoods became battlefields. Hide Caption 2 of 8 Photos: Fearful residents flee western Mosul An Iraqi security officer talks to hundreds of detained men and boys who fled western Mosul. The group gathered at a processing facility south of Mosul before being transferred to nearby refugee camps. Hide Caption 3 of 8 Photos: Fearful residents flee western Mosul A young Iraqi boy smiles as he sits on a bus before being transported with his mother and other civilians fleeing western Mosul to a nearby refugee camp. Hide Caption 4 of 8 Photos: Fearful residents flee western Mosul Two Iraqi women arrive with their children and a few possessions at a reception point for internally displaced people south of Mosul. Hide Caption 5 of 8 Photos: Fearful residents flee western Mosul Iraqi civilians flee Mosul as the fight to rid the city of ISIS fighters continues. Hide Caption 6 of 8 Photos: Fearful residents flee western Mosul A young Iraqi boy carries a bag on his back as he walks in the rain to a civilian processing station south of Mosul. Some civilians have made the dangerous escape on foot from western Mosul. Hide Caption 7 of 8 Photos: Fearful residents flee western Mosul An Iraqi child eats his first hot meal in 10 days at an Iraqi military reception point for internally displaced people south of Mosul. Hide Caption 8 of 8

At least 14,000 civilians fled Mosul on Thursday alone, the ministry said.

"All we've had for the last month is bread and water" said a Mosul resident named Ahmed, who declined to give his full name for fear of reprisals. He came with his wife and five children from the Ma'moun neighborhood in southwestern Mosul.

"We left when mortar rounds started hitting around our house. We couldn't stay any longer," said his wife, Mariam.

The number of refugees is expected to increase as the battle for western Mosul closes in on the heart of that side of the city, migration ministry head Saif Sabah said.

Sabah told CNN that officials have seen "greater and higher numbers" of civilians fleeing western Mosul than from the eastern side of Mosul.

The number of civilians are "double and even triple per day to that compared to eastern Mosul," Sabah said. "We are only 13 days in (to heavy fighting in that part of the city) .... and the numbers have exceeded our expectations."