5 Karutha Rathrikal (1967) The story of Karutha Rathrikal is about a medicine which causes multiple personality disorder. The story was inspired by The Strange Case of Dr Jekyll and Mr Hyde.

Language: Malayalam

6 Vikram (1986) An action-adventure film about intercontinental ballistic missiles (ICBM), advanced computers and security systems.

Language: Tamil

7 Jaithra Yaathra (1987) A film about a scientist who invents a locket that can make people invisible.

Language: Malayalam

10 Nalaya Manithan (1989) Nalaya Manithan is set in the early 21st century, and is about a murderer who gets resurrected by scientists.

Language: Tamil

14 Koi... Mil Gaya (2003) A scientist develops a communications device to send signals into space. The device attracts the attention of aliens. A flying saucer arrives, and causes the scientist to have a car accident. The scientist dies, and his pregnant wife is injured in the crash. Due to the accident, their son is born intellectually impaired. About 20 years pass, the son has grown up physically but still has the mind of a child (and still attends elementary school). The son discovers his father’s communications device, and uses it.

Language: Hindi

15 New (2004) A child turns into a grown man after an experiment by a scientist. Has similarities to the American movie Big.

Language: Tamil

16 Rudraksh (2004) A sci-fi / fantasy film about a group of scientists and a man with inexplicable paranormal powers.

Language: Hindi

18 Krrish (2006) The sequel to Koi… Mil Gaya. The main character in Krrish is the son of the main character in Koi… Mil Gaya, and has inherited his father’s super human strength and intellect granted to him by the alien. The main character becomes the super hero Krrish.

Language: Hindi

19 Alag (2006) Alag (He Is Different…. He Is Alone…) is about a young man who develops telekinetic powers.

Language: Hindi

20 Bharathan Effect (2007) Bharathan Effect is about an inventor that makes a small gadget fly without fuel using the concept of anti-gravity.

Language: Malayalam

23 Viyabari (2007) A business man asks a scientist to clone him.

Language: Tamil

24 Dasavatharam (2008) Dasavatharam begins with narrated stories of historical conflicts in India, and eventually becomes a story about a scientist who engineers a biological weapon and tries to prevent it from being used.

Language: Tamil

25 Love Story 2050 (2008) A science fiction / fantasy film where a group of people travel forward in time to Mumbai in 2050. The future Mumbai depicted in this film includes flying cars, holograms, robots, and 200-story buildings.

Language: Hindi

27 Prince (2010) An action movie about a master thief with an erased memory.

Language: Hindi

29 7 Aum Arivu (2011) A genetic engineering student tries to bring back the skills of a legend from the past, to save India from a deadly virus attack by China.

Language: Tamil

30 Ra.One (2011) The hero and villain of a video game come to life. The villain tries to kill the video game creator's son, while the hero tries to save him. The film has similarities to Tron Legacy and Terminator 2.

Language: Hindi

32 Joker (2012) A sci-fi comedy about a scientist working on a top secret project for creating a device to communicate with aliens. The scientist travels to a village between India and Pakistan (that by mistake belongs to neither country), which was declared as its own republic by some insane asylum escapees 60 years earlier.

Language: Hindi

33 Maattrraan (2012) A scientist becomes wealthy after developing a memory improving energy drink.

Language: Tamil

35 For Real (2010) 6 year old Shruti is aware of some secrets which others do not know. She thinks that a stranger has taken over the position of her real mother and then she struggles hard to find out the truth. The film shows Shruti's struggle to keep her family intact when other more powerful grown ups aim to destroy the togetherness of her family.

Language: English

37 Sona Spa (2013) Sona Spa is about a business (of the same name), where clients can pay for ‘sleep workers’ to sleep on their behalf (so the clients don’t have to). The ‘sleep workers’ have the same dreams as what the clients would have had.

Language: Hindi

39 Kanthaswamy (2009) A super hero movie also known as Mallana (Telugu dubbed version) and Shiva - The Superhero (Hindi dubbed version).

Language: Tamil

40 An Human (2011) A sci-fi mystery film about a software engineer who suddenly quits his job and leaves his flat. His flatmates question his motivations, which leads to an unexpected and unbelievable answer. His flatmates try to debunk his claims.

Language: Tamil

41 Adhisaya Ulagam (2012) A scientist builds a time machine. The scientist and his two grandchildren travel back to a time when dinosaurs were alive.

Language: Tamil

43 Appuchi Gramam (2013) Appuchi Gramam is about a village in Tamil Nadu that is at the predicted impact point of a meteorite detected by ISRO scientists.

Language: Tamil

44 PK (2014) PK is a scifi comedy about an alien who is stuck on Earth after his spaceship remote is stolen. After taking some idiomatic answers to his questions literally, he begins to investigate/practice various religions (because supposedly god knows where his remote is). PK became the highest grossing Indian movie of all time.

Language: Hindi

45 Mr. X (2015) Mr. X is about a man who consumes an untested healing potion, which causes him to become invisible (except under neon lights or direct sunlight). He becomes a vigilante, and seeks revenge on those who wronged him.

Language: Hindi