A new study of mice suggests skipping meals may disrupt metabolism in a way that leads to extra fat accumulating around the middle and signs of prediabetes. Share on Pinterest The researchers suggest skipping meals to save calories could be counterproductive as it results in larger fluctuations of insulin and glucose that can lead to more fat gain instead of fat loss. Writing in the The Journal of Nutritional Biochemistry, the researchers, including members from Ohio State University in Columbus, describe how they compared mice allowed to nibble their food throughout the day with mice that ate their food in one session and then fasted for the rest of the time. They found that the mice that gorged all their day’s food in one session and fasted in between developed insulin resistance in their livers – an indicator of prediabetes – and more fat in their abdomens. When the liver becomes less sensitive to insulin, it keeps producing glucose when it is not needed, so the blood ends up with too much sugar and the excess is stored as fat. For the experiment, the researchers initiated gorging behavior in the mice. They had two groups of mice: the control and the intervention group. Controls were given their full daily food ration once a day – which they nibbled all day. At first, the intervention group was given a restricted calorie diet. For 3 days their daily food ration had half the calories of that given to the controls. This initiated gorging behavior – they ate all their food in one session and then fasted. Then, over another 3 days, the intervention (now gorging) mice were gradually given more and more calories until their rations were the same as the controls. But they continued with their gorging and fasting pattern – they did not go back to nibbling like the controls. They ate all their food in a period of 4 hours and then fasted for 20 hours.

Gorging mice had same weight but more belly fat than mice that nibbled all day Over the period of the experiment the researchers measured various metabolism indicators in the mice. They found that at first, as they were on calorie restriction, the intervention mice lost weight compared with the controls. And as they were given more and more calories, their weight returned to match the controls. But around their middles – where humans carry their belly fat – by the end of the experiment, the gorging mice had accumulated heavier amounts of abdominal fat. Carrying excess belly fat is linked to insulin resistance and higher risk of developing type 2 diabetes and heart disease. Senior author Martha Belury, professor of human nutrition at Ohio, says their findings support the idea that eating small meals throughout the day can help lose weight, although that may not be practical for everyone. However, she also notes: “But you definitely don’t want to skip meals to save calories because it sets your body up for larger fluctuations in insulin and glucose and could be setting you up for more fat gain instead of fat loss.” She says by the end of the experiment, the intervention mice were basically bingeing and fasting. “People don’t necessarily do that over a 24-hour period, but some people do eat just one large meal a day,” she notes.