TALLAHASSEE, Fla. -- Top-ranked Florida State suffered another loss along the defensive line Thursday when coach Jimbo Fisher ruled out defensive Mario Edwards Jr. for Saturday's game against NC State.

Edwards, a junior, is dealing with a concussion that occurred in the first half of last weekend's overtime win against Clemson. He did not play in the second half.

Defensive tackle Nile Lawrence-Stample was also injured against Clemson and will miss the season with a torn pectoral, which leaves the Seminoles with a reshaped line. Tackle Eddie Goldman and end DeMarcus Walker have started all three games.

Redshirt sophomore defensive end/linebacker Chris Casher will start in place of Edwards against the Wolfpack. Casher played admirably in Edwards' stead against Clemson, producing several big plays in the second half, including a touchdown-saving tackle and a fourth-down stop in overtime.

Edwards has eight tackles and one sack this season.

Backup running back Mario Pender (concussion) and linebacker Ukeme Eligwe (foot) are also ruled out for NC State.

Fisher also said backup DT Justin Shanks is returning from a lower leg injury suffered in the first half against The Citadel in Week 2. He missed the Clemson game.