For the sixth time since President Barack Obama took office, Senate Republicans failed to secure enough votes to roll back an administration policy today, falling short on blocking new emissions standards.

On a 46-53 vote, the Senate rejected a resolution of disapproval on the Environmental Protection Agency’s Utility MACT rule, which tightens the emissions standards for factories and has been viewed as a win for environmentalists and a loss for the coal industry. In the lead-up to the disapproval vote, sponsored by Environment and Public Works ranking member James Inhofe (R-Okla.), the effort became a cause célèbre for Republicans, with the Heritage Foundation and the tea-party-influenced FreedomWorks weighing in.

Five Democrats — Sens. Mark Warner and Jim Webb of Virginia, Mary Landrieu of Louisiana, Joe Manchin of West Virginia and Ben Nelson of Nebraska — voted with Republicans.

Five Republicans — Sens. Olympia Snowe and Susan Collins of Maine, Scott Brown of Massachusetts, Kelly Ayotte of New Hampshire and Lamar Alexander of Tennessee — joined Democrats in voting the measure down.

“This regulation would expand the already massive powers given to the EPA by increasing red tape and costing the taxpayer over $10 billion dollars each year,” Senate Minority Leader Mitch McConnell said today on the floor.