The script, written by Hill from a story by Denis Hamill, centers on an ace assassin who is double-crossed by gangsters and falls into the hands of rogue surgeon known as "The Doctor," who turns him into a woman. The hitman (now a hitwoman) sets out for revenge, aided by a nurse named Johnnie, who also has secrets.

Rodriguez is to play the hitman while Weaver is the scalpel-wielding doctor when the cameras roll Nov. 9 in Vancouver.

The project initially made the rounds at TIFF and had Frieda Pinto involved. Pinto is no longer involved.

The Solution Entertainment Group, co-founded by Lisa Wilson and Myles Nestel, is handling international sales on the project which will see at the American Film Market. ICM is representing North American rights.

Tomboy will mark the first movie Rodriguez has toplined in quite a while. The actress is known for her work within large casts, mostly in the action and sci-fi sphere with the Fast franchise, the Resident Evil movie series, the Machete flicks and Avatar.

She is repped by WME, Untitled and Greenberg Traurig.