Oprah Winfrey in an interview appeared to dismiss speculation on a potential 2020 presidential run, saying she does not "have the DNA" to launch a bid for the White House.

"I’ve always felt very secure and confident with myself in knowing what I could do and what I could not. And so it’s not something that interests me. I don’t have the DNA for it," Winfrey told InStyle Magazine's editor-in-chief, Laura Brown, in an interview published Thursday.

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Speculation that Winfrey would launch a 2020 bid reached a fever pitch earlier this month after the celebrity delivered a stirring speech addressing the "Me Too" and "Times Up" movements at the Golden Globes.

“For too long, women have not been heard or believed if they dared to speak their truth to the power of those men,” Winfrey said while accepting the Cecil B. DeMille Award at the ceremony. “But their time is up. Their time is up!”

President Trump Donald John TrumpUS reimposes UN sanctions on Iran amid increasing tensions Jeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Trump supporters chant 'Fill that seat' at North Carolina rally MORE himself addressed the speculation, telling reporters he did not think she would run, but if she did he believed he would beat her.

"Yeah, I'll beat Oprah. Oprah will be lots of fun,” the president said. “I don’t think she’s going to run.”

A CNN poll published Tuesday found that Trump trailed Winfrey, as well as former Vice President Joe Biden Joe BidenMomentum growing among Republicans for Supreme Court vote before Election Day Trump expects to nominate woman to replace Ginsburg next week Video of Lindsey Graham arguing against nominating a Supreme Court justice in an election year goes viral MORE and Sen. Bernie Sanders Bernie SandersNYT editorial board remembers Ginsburg: She 'will forever have two legacies' Two GOP governors urge Republicans to hold off on Supreme Court nominee Sanders knocks McConnell: He's going against Ginsburg's 'dying wishes' MORE (I-Vt.) in a 2020 matchup.