Police have arrested and charged a man with one count of murder following the death of a man in Greenacre.

The 22-year-old man died after he was stabbed in the chest at a home in Sydney's south-west on Friday afternoon.

Police confirmed the man died just before 2pm on Friday, when they were called to a property on Wangee Road in Greenacre.

Paramedics attempted to save the man using CPR but he died at the property.

Two crime scenes were established; one on Wangee Road and another on Roberts Road, according to police.