Ibuprofen is great for squashing a headache. Turns out, the pain medication can also block a marijuana high, which can be either a bummer or a benefit depending on your perspective.

According to a new study performed on mice by researchers at the Louisiana State University Health Sciences Center and published in the Cell journal, chemicals in the over-the-counter painkiller allow the plant’s therapeutic benefits to kick in with no buzz, no memory loss and no loss of motivation. The findings could help provide a way for patients who use marijuana to combat pain but who don’t like to get stoned, find relief. And they could expand other legal treatment options for people suffering from chronic disease.

“Our studies have solved the longtime mystery of how marijuana causes neuronal and memory impairments,” one of the study’s authors said in a statement. “The results suggest that the use of medical marijuana could be broadened if patients concurrently take a nonsteroidal anti-inflammatory drug such as ibuprofen.”

– Read the entire article at AlterNet.