The Jets may be without two of their top defensive players for Monday’s game against the Browns.

Coach Adam Gase said linebacker C.J. Mosley and defensive lineman Quinnen Williams are unlikely to practice Wednesday and their status beyond that is murky.

Mosley underwent an MRI exam on Monday for a groin injury he suffered in the third quarter of Sunday’s 17-16, season-opening loss to the Bills. Mosley had played a fantastic game in his Jets debut, including an interception returned for a touchdown, before he was injured.

“It’s hard for me to tell because it’s all about how he reacts,” Gase said when asked about a timeline for Mosley. “Anything soft tissue, it’s all just kind of subjective on how they feel. It gets so day-to-day and any kind of setback can prolong it. We just have to see how he feels every day before we get going.”

Williams, the rookie from Alabama, had a quiet first game. He sprained an ankle in the second half and is in a walking boot, Gase said. It was unclear whether it was a high-ankle sprain, which generally takes longer to return from.

Center Ryan Kalil said he felt great physically Sunday, but admitted to struggling with communication in his first game as a Jet. Kalil signed with the team in early August and did not play in the preseaso

“I felt like I was playing slow at times just mentally,” Kalil said, “trying to overthink everything instead of just coming off the ball and playing fast.”