An independent Super PAC aligned with Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellTrump 'no longer angry' at Romney because of Supreme Court stance On The Money: Anxious Democrats push for vote on COVID-19 aid | Pelosi, Mnuchin ready to restart talks | Weekly jobless claims increase | Senate treads close to shutdown deadline The Hill's Campaign Report: Trump faces backlash after not committing to peaceful transition of power MORE (R-Ky.) on Thursday voiced strong opposition to Roy Moore Roy Stewart MooreRoy Moore sues Alabama over COVID-19 restrictions Vulnerable Senate Democrat urges unity: 'Not about what side of the aisle we're on' Sessions hits back at Trump days ahead of Alabama Senate runoff MORE's decision to run for Alabama Senate again, saying that nominating him would be "gift wrapping" the seat to Democrats.

“We believe most Alabama Republicans realize that nominating Roy Moore would be gift wrapping this Senate seat for Chuck Schumer Chuck SchumerPelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' 3 reasons why Biden is misreading the politics of court packing Cruz blocks amended resolution honoring Ginsburg over language about her dying wish MORE," Senate Leadership Fund Communications Director Jack Pandol said in a statement. "It remains to be seen whether Moore can escape his baggage without his candidacy collapsing under its own weight, regardless of what groups on the outside do."

The statement came just moments after Moore, a former Alabama Supreme Court justice, announced that he would challenge Sen. Doug Jones (D-Ala.) for his seat in 2020. The move comes after the controversial Republican lost to Jones in a 2017 special election to replace former Sen. Jeff Sessions Jefferson (Jeff) Beauregard SessionsRoy Moore sues Alabama over COVID-19 restrictions GOP set to release controversial Biden report Trump's policies on refugees are as simple as ABCs MORE (R-Ala.)

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Moore gained massive scrutiny during the race over allegations that he pursued sexual and romantic relationships with teenage girls in the 1970s when he was in his 30s. Moore has adamantly denied the accusations, and received support from President Trump Donald John TrumpSteele Dossier sub-source was subject of FBI counterintelligence probe Pelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Trump 'no longer angry' at Romney because of Supreme Court stance MORE during the campaign.

“I will run for the U.S. Senate in 2020,” Moore told supporters in Montgomery, Ala. on Thursday. “Can I win? Yes, I can win.”

McConnell suggested before Moore's announcement that Republicans would proactively work to oppose his nomination.

“He can do what he wants to, but we’re certainly going to oppose him in every way,” McConnell told the Associated Press

"I can assure everyone that by running, Roy Moore is going against my father and he’s doing a disservice to all conservatives across the country in the process," he said on Twitter