The series will return in November and wrap its run with its 100th episode, set for 2017.

It's the end of the road for MTV's Teen Wolf.

Producers and stars from the remake of the 1985 Michael J. Fox feature film announced Thursday during the show's annual Comic-Con panel that the previously announced sixth season will be its last. The series returns in November to kickoff its 20-episode run and will conclude with its landmark 100th episode in 2017.

"Teen Wolf has been an extraordinary journey, one that captured the hearts and imaginations of fans more than we could've ever imagined," said showrunner and executive producer Jeff Davis. “We’re eternally grateful for the support we’ve received over these past six years and we’re excited to take our brave fans on one last, thrilling adventure.”

Thursday's appearance marked the seventh time the cast — including stars Tyler Posey, Holland Roden, Dylan Sprayberry, Cody Christian and Khylin Rhambo — made the trek to San Diego. Fellow stars Ian Bohen and J.R. Bourne made a surprise appearance by storming the Comic-Con stage dressed as the show's newest villains, the Ghost Riders, and the trailer for the final season also unspooled during the afternoon session (watch, below).

For MTV, the decision to end Teen Wolf comes as the genre drama ranks has the Viacom-owned cable network's longest-running original scripted series of all time. Its current drama roster also consists of Scream and The Shannara Chronicles, both of which are also based on IP. The network used Teen Wolf's final bow to preview its forthcoming scripted dramedy , Sweet/Vicious, starring Taylor Dearden and Eliza Bennett in an offbeat superhero story about sexual assault, consent and revenge on college campuses. The hourlong series is set to bow alongside Teen Wolf in November.