Things looked good in the early stages of the season for Saint Louis FC, but an inability to string together consistent results over the remainder of the season meant that the club would again have to wait for its first trip to the USL Cup Playoffs. Saint Louis was unable to record back-to-back wins for the remainder of the season after a three-game winning streak put the club at 3-0-1 to start the year, and the year ended with the departure of Head Coach Preki after one season in charge.

Saint Louis only brought back five players from a disappointing 2016 season, bringing in plenty of experience from around the rest of the league to form what looked on paper to be a competitive team. The squad used that experience to start well, but the club's defenses weakened as the year went on, conceding 48 goals, the most the team had given up in a single season in the club's short three-year history.