Police say they have disrupted an international drugs syndicate after seizing about 40 kilograms of the drug ice in Sydney's inner west.

Officers arrested a 47-year-old Lidcombe man and a 54-year-old Chinese national yesterday.

They allege the men were caught carrying out a deal in a public car park in Campsie.

The pair are facing charges for the supply of a large commercial quantity of methamphetamines.

Police say half a kilogram of cocaine and $2.6 million in cash were found with the ice.

Assistant Police Commissioner Mal Lanyon says the seizure will make an impact on the ice trade.

"Forty-five kilograms can be broken down to approximately 1.3 million street deals," he said.

"So it is a very significant seizure in terms of the reduction in harm that that can lead to."

The suspects are expected to face Burwood Local Court this afternoon.

Police say the bust was made after a joint investigation involving state and federal police, the state and federal crime commissions, and Customs officials.