Celebrity hangout and Italian-cuisine pioneer Da Silvano, a favorite of boldfaces and sophisticated eaters alike, has closed after 41 years in Greenwich Village.

Owner Silvano Marchetto confirmed to The Post, “Last night was our last night. We are closed forever.”

A grim-sounding Marchetto blamed soaring operating costs including new minimum-wage rules and rent that escalated from $500 a month in 1975 to $41,000 a month today.

“I can’t do it anymore,” Marchetto said.

Da Silvano first popularized northern Italian food in New York at a time when most Italian restaurants served Americanized “red sauce” dishes.

But Da Silvano was better known as a hangout for superstars including Madonna, Sean Penn, Owen Wilson, media moguls like Barry Diller and Ana Wintour, and for art world luminaries.

Among other scandalous incidents, it was where, in 2004, Britain’s Princess Michael of Kent notoriously, allegedly told a table of black diners to “go back to the colonies.”

In 2013, art dealer Tony Shafrazi threw a tantrum at Owen Wilson and art collector Peter Brant in front of other customers on the restaurant’s sidewalk patio. “Shafrazi was cursing them both out while Owen was eating a dandelion and heirloom tomato salad,” a witness told Page Six at the time.