This year marks the 150th birthday of Frank Lloyd Wright, America’s most famous architect.

While New Yorkers are most familiar with his last major project, New York’s Guggenheim Museum, he’s renowned for his houses which blew up prevailing Victorian forms.

Luckily, fans of architecture — and road trips — can take in a variety of Wright’s residential work in a long weekend.

The trip not only includes the iconic Fallingwater, aka The Edgar J. Kaufmann house, but Wright-designed houses that can be rented out.

The drive will take you to western Pennsylvania, about six hours from Midtown via Harrisburg Start at the crack of dawn to make the in-depth tour at your first stop, Kentuck Knob in rural Ohiopyle, Penn. ($60 at 1:15 p.m. for a 5½-hour tour; $25 for shorter tours throughout the day).

Wright built the one-story, crescent-shaped Kentuck Knob — which appears recessed into a hill — between 1953-56 for Bernadine and Isaac Newton Hagan, friends of the Kaufmanns (and fans of their house). The result was one of Wright’s deceptively simple “Usonian” houses, a model designed to cut costs for mostly middle-class families (there are no basements or attics, for example).

Kentuck Knob is a great introduction to Wright’s work: It’s in pristine condition and current owner has collected a number of Wright furnishings, including items from the Imperial Hotel in Tokyo and Wright’s earlier, Prairie-style homes.

Be sure to walk back to the visitor’s center via the wooded path that’s home to an impressive collection of British sculpture.

For your next stop, you have two choices: If you want to sleep in a Usonian home, just 45 minutes away is Polymath Park a quasi architectural sleepaway camp in the Pennsylvania woods where you can bunk at several homes, including the Duncan House, a long, low home with yellow siding interspersed with red-painted wood stripes (from $399 a night for entire house; $24 for approximately 1-hour tour). Originally located in Illinois, it was dismantled and moved to the park in 2002. An additional Wright house, recently relocated from Minnesota, is expected to be open to guests this year.

Also available to stay in are two homes by Wright apprentice Peter Berndtson (from $299 a night). Keep in mind that guests who stay more than one night at Polymath Park will have tours groups in their lodging in the afternoons, so plan accordingly.

If you don’t stay overnight in Polymath, to keep your road trip in the right direction stay at Hartzell House Bed & Breakfast in Addision, Penn., about 30 minutes from Fallingwater (from $155). Visit Fallingwater, then continue on to Polymath. The B&B’s breakfast, served early enough to accommodate the first Fallingwater tour, is superb.

Fallingwater is Wright’s masterpiece, and you’ll see clearly how fitting the house into the landscape was more than an architectural gimmick; with Wright’s cleverly designed windows flung open and creek rushing below, you’ll experience how the architecture and nature meld into one ($80, 8:30 a.m. for 2-hour tour; $30 for shorter tours throughout the day).

All tickets give you unlimited access to the tranquil grounds — a small portion of the 5,000-acre Bear Run Nature Reserve — throughout the day, so stay and enjoy the woods and waterfalls.

From there (or Polymath), take the rest of the day to drive up to Buffalo, NY, approximately four hours away, where the next day you’ll visit two Wright houses: the 1905 Darwin D. Martin home, the largest designed in Wrights’ Prairie style and part of the Martin House Complex, and the 1929 summer home, Graycliff Estate, the summer home designed for Martin’s wife, Isabelle.

For Buffalo accommodations, we recommend you go for the package deal at the Hilton Garden Inn downtown that features a good room rate along with tickets to the Darwin D. Martin house (from $139).

Start the next day at Graycliff, 16 miles south in nearby Derby, NY. The in-depth tour of both the house and grounds showcases another example of how Wright integrated his work into the landscape ($34 for 2-hour tour; $18 for shorter tours).

The visit to dilapidated Graycliff can be a shock — but seeing the house’s “bones” helps visitors understand Wright’s process. After the Martins sold the house, subsequent owners heavily remodeled it, stripping some of Wright’s original details. Now run by a non-profit, the house and grounds are in the process of a painstaking restoration, and the guides do an expert job of showing just how much work is needed to keep Wright’s architectural heritage alive.

In the afternoon, head back to Buffalo to the Martin House Complex. The 1905 Darwin D. Martin home is among the largest designed in Wright’s Prairie style. Also on the property is the 1903 Barton house (also by Wright), built for Darwin Martin’s sister and her husband, along with reconstructions of the pergola, conservatory and carriage house, which were demolished in the early 1960s ($37 for two-hour tour, included in the hotel package; $19 for one-hour tour).

Feeling really ambitious? On select dates there’s an All Wright, All Day tour ($135 including transportation) that not only takes you to Graycliff and the Darwin D. Martin house, but also covers other Wright sites in Buffalo, including a gas station built to the architect’s designs and housed in the Pierce Arrow Museum, and the former site of the Larkin Administration Building, Wright’s first major commercial commission.

If you drove, get a good night’s sleep! You have a six-hour drive on the interstate back to New York City.

How to go

There are one-way nonstop flights from JFK and LaGuardia to Pittsburgh, 1½ hours from your first Wright stop (from $215 on Delta; you’ll need to rent a car from there). On the return, get a one-way ticket from Buffalo back to JFK (from $67 on JetBlue); you can get a similarly priced flight on United Airlines to Newark. Car rentals from New York City from $50 a day via Budget.