Afeni Shakur Davis, Tupac’s mother, has died at the age of 69.

Officers with the Marin County Sheriff’s Office responded to reports of a possible cardiac arrest. She was transferred to a local hospital where she died at 10:28pm.

The Sheriff’s Coroners Office will lead an investigation to the exact cause of her death.

She was a highly-influential activist as a member of the Black Panther party. After her 25-year-old son was killed in 1996, Davis took over her son's estate, which makes more than $900,000 a year, TMZ reports.

She also founded the Tupac Amaru Shakur Foundation, and co-produced 2014 Broadway musical Holla If Ya Hear Me, which featured her son's music.

The killing of her son has gone unsolved, but Davis was more focused on committing herself to her son’s message.

“Not a second. Not even a nanosecond have I concerned myself with who shot him or why they shot him, or what should happen to them,” Davis told CBS News in 2003. “I don't care what happens to them. I spend my time putting my sons work out, because guess what — they shot him, but did not shut him up though.”