A 25-year-old Italian cyclist was allegedly car-doored on a notorious road in Melbourne's inner north before being hit by a truck and killed.

Victoria Police said the man, an Italian national, was cycling south on Sydney Road just after 4:00pm when a person in a parked car opened their door, knocking him onto the road.

He was then struck by a passing truck and died at the scene, police said.

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He was believed to have been cycling with his partner at the time of the incident.

Both the truck driver and the occupant of the parked car were assisting police with enquiries.

Sydney Rd has one of the highest accident rates for cyclists in the state, prompting police and VicRoads to conduct an "enforcement and awareness" campaign over the summer.

In December last year, Adam Maguire from VicRoads said 85 cyclists had been involved in crashes on the road in the past five years.

"It's a very high rate, it's very alarming," Mr Maguire said.

He said many of those crashes involved car doors being opened into the path of cyclists, and cyclists colliding with oncoming traffic while attempting to turn right.

"We really want cyclists to be safe, we want people to respect each other and understand that they are sharing the road space together," he said at the time.

Police appealed for anyone who witnessed the incident to contact Crime Stoppers.