Saquon Barkley and Sterling Shepard may not be the only difference-makers Daniel Jones won’t have at his disposal Thursday night.

Tight end Evan Engram’s status is now uncertain, too.

ESPN’s Adam Schefter reported Engram has a sprained MCL in his knee and tweeted “it’ll be a challenge” for him to be ready to face the Patriots. Engram, however, did practice on a limited basis on Tuesday after being held out on Monday, and a source said the injury is “mild.” Engram wore a sleeve on his left leg during the portion of practice open to the media.

Coach Pat Shurmur didn’t offer much insight on Engram’s status, merely saying “we’ll see,” when asked if he would be a game-time decision. There also wasn’t a packed travel bag next to Engram’s locker, like there was for most of the team besides Barkley, Shepard and Wayne Gallman (concussion). Players declared out typically don’t travel to away games, though the team isn’t traveling until Wednesday.

Engram has gotten off to a terrific start, notching team-highs of 33 receptions for 373 yards and two touchdowns. If he can’t go, it would be another major blow to the Giants, who will be without Shepard (concussion), their No. 1 receiver, and may not have the services of Barkley (high ankle sprain), either.

Rhett Ellison, the only other Giants tight end with a reception this season, would likely start if Engram is out. Garrett Dickerson and Kaden Smith are other options, albeit inexperienced ones.