Train commuters in Melbourne's east are facing big delays after a truck hit a rail bridge.

In the video above: Two-dead after multi-car crash in regional Victoria

The truck hit the bridge over Warrandyte Rd at Ringwood about 6.30am on Monday, according to Victoria's Department of Transport.

Metro Trains has warned those who use the Belgrave and Lilydale lines will face significant delays.

"Listen for announcements and check platform displays as services may be altered at short notice," Metro Trains said in a tweet.

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There are delays on the Belgrave and Lilydale lines of at least 25 minutes.

Major delays have also struck the Sandringham line with a fault near Brighton Beach leaving it suspended.

Buses are replacing trains.