Police arrested two men on Saturday following a shooting in Melbourne's south-west which left a 53-year-old Point Cook man fighting for his life.

Former police detective turned real estate agent Sid Morgan was shot in the face on Spraypoint Drive, Point Cook, just before 11pm on Thursday.

He remains in hospital with life-threatening injuries.

A manhunt began after the unknown offender allegedly fled the scene, leaving his victim to die.

On Saturday, police arrested a 29-year-old Point Cook man in the country town of Nagambie, more than 150 kilometres north of the crime scene. They also arrested a 30-year-old man in Point Cook on Saturday morning.

Homicide Squad detectives are investigating and both men are assisting police with their enquiries.

Anyone with information is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report at www.crimestoppersvic.com.au