House Republicans’ most prolific fundraiser is vowing to continue to do all he can to help them keep the majority in the midterms.

But Speaker Paul D. Ryan’s announcement Wednesday that he doesn’t want to be a part of that majority next year has only crystalized the perception that the House GOP is in for a drubbing in November.

“It’s over,” one GOP operative who’s worked on House and Senate races said.

Ryan is one of 25 House Republicans not seeking re-election or another office in a cycle when President Donald Trump remains a constant distraction from the legislative agenda GOP lawmakers want to be touting.

Watch: Losing Ryan’s Fundraising Prowess Adds to GOP’s Midterm Woes