Sen. Ron Wyden Ronald (Ron) Lee WydenGOP senator blocks Schumer resolution aimed at Biden probe as tensions run high Republican Senators raise concerns over Oracle-TikTok deal Hillicon Valley: TikTok, Oracle seek Trump's approval as clock winds down | Hackers arrested for allegedly defacing U.S. websites after death of Iranian general | 400K people register to vote on Snapchat MORE (D-Ore.), the top Democrat on the Senate’s tax-writing committee, said early Thursday that he is optimistic that the GOP tax-reform proposal will fail in the upper chamber.

Wyden said on CNN's "New Day" that Democrats went against the odds and successfully defeated the GOP push to repeal and replace ObamaCare earlier this year, and that they can do it again with the Republican tax-reform efforts.

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"What I am saying is, much like health care, we are seeing Republican senators express their concerns," Wyden told host Chris Cuomo.

"Right now, I think we are seeing a lot of senators having some doubts, and we see a lot of them concerned about the fact that people are going to lose health insurance coverage, premiums are going to go up. They are concerned about deficits," Wyden, the Senate Finance Committee's ranking member, added.

He named several Republican colleagues who have expressed concern about the legislation, including Sens. Ron Johnson Ronald (Ron) Harold JohnsonThe Hill's Morning Report - Sponsored by The Air Line Pilots Association - White House moves closer to Pelosi on virus relief bill Second GOP senator to quarantine after exposure to coronavirus GOP-led panel to hear from former official who said Burisma was not a factor in US policy MORE (Wis.), Bob Corker Robert (Bob) Phillips CorkerHas Congress captured Russia policy? Tennessee primary battle turns nasty for Republicans Cheney clashes with Trump MORE (Tenn.), Susan Collins Susan Margaret CollinsJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Trump supporters chant 'Fill that seat' at North Carolina rally Momentum growing among Republicans for Supreme Court vote before Election Day MORE (Maine) and John McCain John Sidney McCainMomentum growing among Republicans for Supreme Court vote before Election Day McConnell urges GOP senators to 'keep your powder dry' on Supreme Court vacancy McSally says current Senate should vote on Trump nominee MORE (Ariz.).

He suggested that more lawmakers will begin "peeling off."

"We think when they go home for this Thanksgiving break they're not going to be able to walk through the grocery store without getting a lot of flack from middle-class families, for this bill that is stacked for the multinational corporations and not for working families," he continued.

With a narrow majority in the Senate and without Democratic support, Republicans can only afford to lose the support of three senators.

"Chris, my whole point is we could beat it," Wyden said.

Johnson on Wednesday became the first Republican senator to say he would oppose the bill unless it is amended to help “pass-through” businesses, which he argues are prioritized lower than corporations as the bill is currently written.

His list of demands, however, appears attainable.