Posted 03 March 2011 - 01:03 PM

PQQ is neuroprotective and does wonders to reduce brain fog during adderall-induced all-niters. Aside from it the immediate benefits of its neuroprotective and NMDA modulating effects, it dramatically improves mitochondrial function (especially in the brain). Most importantly, it stimulates the growth of NEW mitochondria.



IMO, one of the most effective means of reducing and reversing damage from d-amp and Adderall (which in my case was severe) is to support mitochondrial health. In addition to PQQ, I've had great results with ubiquinol + Shilajit, Quinogel (hydrsoluble ubiquinol), ALCAR, GPLC, NADH, D-Ribose, Sodium R-Lipoic acid, and magnesium (elemental, glycerinate, or citrate).



Experientially speaking, Adderall seems to take a massive toll on mitochondrial function, especially when used excessively to avoid sleep. By targeting mitochondrial support with my supplement regimen, I have dramatically reversed much of the perceived cognitive decline caused by three years of heavy Adderall use and (eventually) abuse. I also feel that this stack has been helpful in preventing further damage from continued amphetamine use.



Planetary Herbals' Schizandra Adrenal Complex is incredibly helpful to take at night. This cured my severe adrenal fatigue, and I now use it daily for maintenance. Isocort - used OCCASIONALLY in times of heavy adderall use / adrenal stress - is also very helpful in restoring and maintainig proper adrenal function during chronic amphetamine use.



L-Carnosine, Sam-e, Sulbutiamine, astaxanthin, calcium ascorbate, Opti-Zinc, a vitamin K2 complex (M4 and M7), green tea phytosome, and Siliphos (milk thistle phytosome) have also seemed to help with a lot damage reduction, as has the homocystine lowering stack of P-5-P, methylcobalamin, L-methylfolate and/or megafolinic (advanced forms of folic acid), and TMG.



I also take SAMe for about one week out of the month, which seems to help restore neurotransmitter balance (IMO, not sure if there is research to support this).



Adderall can cause GABA and melatonin deficiencies, especially when used for all-niters. Taking 1-3mg melatonin, 200mg GABA, and 25mg 5-htp before bed has helped me to reclaim more healthy and restorative sleep patterns.



Hyland's homeopathic Nerve tonic is great at bedtime and really seems to help repair and refresh my nervous system overnight. It used to take me at least half an hour or more to wake up in the morning, and I used to need coffee or adderall just to get going. Since adding the Nerve Tonic and the Schizandra complex to my nighttime regimen, I now wake up feeling refreshed and recharged, usually before my alarm even goes off.



Tried Memantine for about a month over Christmas break, during which I abstained from all amphetamine use. I followed the recommended protocol of titrating up from 5mg to eventually 30mg daily by the end of the break, and continued for about another week once resuming adderall use for the spring semester. To my disappointment, it did very little to reverse my existing adderall tolerance and if anything seemed to blunt its effects. I know others have had great results here, but IMO it was not worth the cost.



Of everything that I've tried, PQQ is the most recent addition and seems to be the single most effective component. The results are pretty dramatic, especially at the 20-40mg/day range. Unfortunately it's kind of expensive, but if you shop around you can usually find the Life Extensiom brand BioPQQ brand for about $15 total (inc shipping) per 30-count 10mg bottle.



Additionally, I try to take at least 1-2 days off Adderall/Dexedrine every weekend. On these days I take 700mg alpha-gpc, 500mg Citicoline, and various race tams (cycled). This seems to help my brain repair itself from the stresses of the previous week and let's me start the next one feeling mentally refreshed.



I'm still way too dependent on Adderall and am working to address this, and it seriously messed me up for the better part of last year, but this regimen has fortunately helped to reverse much of the damage already, keep further tolerance buildup under control, and appears to be keeping most further damage at bay. Adderall has seriously damaged my mental and physical health, and for at least a year sucked all happiness out of my life. This stack has allowed to regain control of my life, and has converted an increasingly debilitating addiction into a functional and manageable one.



Hopefully others will will find some of it useful. Feel free to PM me with any specific questions.

