Major venture capitalist Marc Andreessen, who donated to 2012 GOP presidential nominee Mitt Romney, scoffed when asked at a tech conference why he is supporting Hillary Clinton Hillary Diane Rodham ClintonJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Momentum growing among Republicans for Supreme Court vote before Election Day Warning signs flash for Lindsey Graham in South Carolina MORE, the presumptive Democratic nominee, over Donald Trump Donald John TrumpUS reimposes UN sanctions on Iran amid increasing tensions Jeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Trump supporters chant 'Fill that seat' at North Carolina rally MORE.

“Is that a serious question?” he asked on Monday, according to Recode.

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Andreessen, a Facebook board member, said he usually picks candidates based on their stance on immigration, trade, science and free markets. He said neither party is very good right now on science.

“I think, clearly, one of the candidates is way better than the other, interestingly on all four, and so to me, it seems like it's a fairly obvious choice," he said.

In an apparent shot at Trump's immigration policies, Andreessen said the idea of cutting off the flow on immigrants "makes me sick."

"The Valley wouldn't be here, we wouldn't be doing any of this if we didn't have the amazing flow of immigrants that we've had in the last 80 years," he said.

Andreessen has taken to Twitter in the past to air his criticism of Trump. Many Silicon Valley Republicans are uneasy with Trump as the presumptive GOP presidential nominee, though Andreessen's fellow Facebook board member, Peter Thiel, was selected to be a delegate for Trump at the Republican National Convention in July.

Andreessen has donated thousands of dollars to politicians and outside groups over the past decade. But his largest donations came in 2011 and 2012, when he gave $100,000 to an outside group supporting Romney.