Several communities in WA's Pilbara region have been cut off from major urban centres after Cyclone Blake tore through the area on Thursday morning.

The cyclone brought extensive flooding to the De Grey River catchment area and prompted several road closures in the Pilbara and the Kimberley regions.

Marble Bar Road remains closed in both directions between Great Northern Highway, near Port Hedland, and Newman, leaving Nullagine and Marble Bar completely landlocked.

Nullagine remains cut off from major urban centres in the aftermath of Cyclone Blake. Credit:Alex Xavier

Residents in Nullagine said the crossing into the small Pilbara community is under three metres of water and estimate it may be a while before it is safe enough to cross.