Grey’s Anatomy is tackling a different kind of epidemic when it returns for Season 12.

When two young girls are admitted to Grey Sloan Memorial in the ABC drama’s season premiere (Sept. 24, 8/7c), their “powerful” story will force several staffers to reflect on how bullying has shaped them into the people they are today.

New photos from the episode give us a peek of that drama unfolding, as well as a look at what’s in store for the new docs scrubbing in at Grey-Sloan Memorial, including the heavily-featured Giacomo Gianniotti (Reign, Selfie), whose casting TVLine broke earlier this year.

Also on tap for the show’s first post-McDreamy premiere: Meredith attempting to settle in with her new roommates, Bailey battling against guest-star Joey Lauren Adams (Switched at Birth) for the Chief of Surgery position and Jackson preparing to welcome April home from her trip to Seattle.

Browse the new photos below, then drop a comment: What do you hope to see in Grey’s Anatomy Season 12?