Eight games into a season, the Yankees need to link several Carl Pavano Memorial MRI tubes together to snap the team picture.

They started the year without Jacoby Ellsbury, lost Aaron Hicks before the second game and reserve outfielder Billy McKinney following the third. Nobody can predict when any of that trio will return from the disabled list.

Then during various parts of Friday night’s 7-3 loss to the Orioles in 14 innings that was witnessed by 34,244 at Yankee Stadium the Yankees watched starter CC Sabathia, third baseman Brandon Drury, second baseman Tyler Wade and catcher Gary Sanchez depart with physical issues.

Aroldis Chapman was visited by the trainer Tim Lentych and Aaron Boone in the ninth inning when Sanchez noticed a drop in velocity, but said he was fine and remained in the game.

“We had a total of four guys come out, that’s tough,’’ said Aaron Judge, who robbed Caleb Joseph of a home run in the 13th by getting his glove above the right-field fence to make the inning-ending catch.

The initial reports on the four Yankees who departed were encouraging.

Sabathia said the MRI exam on his right hip, which forced him out of the game because of soreness after four innings, was clean.

“Now I know I am not hurt,’’ said Sabathia, who gave up three runs and three hits — two homers by Manny Machado and one by Chris Davis.

Sanchez, who left in the 14th inning, said a doctor checked his right calf out and diagnosed it as a cramp.

“I’ll have to wait and see how I feel [Saturday],’’ said Sanchez, who went 0-for-6 and is in a 1-for-33 funk.

Manager Aaron Boone said Drury was experiencing migraine headaches and blurred vision and Wade was suffering flu-like symptoms and was run down.

As for the game, which took five hours and 20 minutes to complete, the Yankees’ bullpen did a splendid job from the fifth to the 13th inning when the O’s didn’t score a run. However, Johnathan Holder’s second inning opened with a walk, a single and a throwing error by Ronald Torreyes to start the frame. Holder caught Adam Jones looking for the first out, but Horace Mann product Pedro Alvarez drove Holder’s first pitch over the right-field wall for a grand slam.

“Every loss, they are all tough,’’ said Judge, who drove in a run with a single, walked, got hit by a pitch and fanned three times. “We have to bounce back and get ready in a couple of hours.’’

Having used seven relievers with five of them throwing 25 pitches or more, Boone likely will have some new arms arriving for Saturday’s game. Holder threw 42 pitches, so he is a good bet to be replaced. Tommy Kahnle tossed 48, so he won’t likely be used for a while.

If Judge didn’t take a home run away from Joseph for the final run out in the top of the 13th, the Yankees would have been down at least run with three outs remaining. But Judge got his glove above the wall and came down with the ball.

“I timed it right,’’ Judge said.

The Yankees had a big chance to win the game in the 11th when O’s pitcher Mychal Givens threw a pitch to Tyler Austin that got by Joseph with Didi Gregorius on third. But Joseph got the ball to Givens who blocked the plate on Gregorius and tagged him out. The Yankees challenged, but the call stood.

“I thought he blocked the plate, it didn’t go our way,’’ Boone said.

Trailing, 3-2, with one out in the eighth inning Gregorius lofted a fly ball off a 96-mph sinker from Miguel Castro that landed in the right-field seats. It was Gregorius’ third homer and 10th RBI.