"Thursday Night Football" in Week 5 features a remarkable first: All-everything New England Patriots quarterback Tom Brady has never played a regular-season NFL game in Tampa Bay. The Buccaneers "hosted" Brady's Patriots in London in 2009, and including two home games against Tampa Bay in 2005 and 2013, the New England quarterback is 3-0 all time against the Bucs.

Thursday night's game, set to kick off at 8:25 p.m. ET and air on CBS and NFL Network, also will be available via live stream through Amazon Prime Video. It features a trendy pick to make the playoffs out of the NFC South in the Buccaneers (2-1) against the surprisingly average Patriots (2-2), who despite a slow start to the season remain the favorites to win Super Bowl LII.

The key for the Patriots in Week 5 is the ability of their pass defense, which ranks last in the league with 324 passing yards allowed per game, to slow down a Jameis Winston-led Buccaneers attack that ranks third with 277.7 passing yards per game. Of course, Tampa Bay with its 31st-ranked pass defense (315.7 passing yards allowed per game) has the same problem against what is statistically the league's best offense in New England.

PATRIOTS-BUCCANEERS PICKS:

Straight up | Against spread

Here is all the info you need to watch Patriots vs. Buccaneers on Thursday Night Football.

Patriots vs. Buccaneers: Live stream, TV channel, network

Patriots vs. Buccaneers: Live stream | Game center

Kickoff time: 8:25 p.m. ET

TV networks: CBS, NFL Network

Thursday night's game in Tampa Bay will air nationally on CBS and NFL Network. It's the second of five Thursday night games that will be televised on CBS throughout the 2017 season as part of the NFL's Thursday Night Football expansion package for 2016 and '17. NBC also will carry five Thursday night games this season, beginning in Week 10 and not including the NFL season-opener. In addition to CBS and NBC, NFL Network broadcasts every Thursday night game of the season.

Both CBS and NBC provide their lead broadcasters for Thursday Night Football, meaning Jim Nantz and Tony Romo will call the Patriots-Buccaneers game Thursday night from the booth in Tampa Bay.

Because it won an offseason bidding war, Amazon will provide live streaming services for 10 Thursday Night Football games in 2017. Patriots vs. Buccaneers is the second of such games, which coincide with the CBS and NBC Thursday Night Football broadcast schedules. Amazon also provided a live stream for the Week 3 Jaguars-Ravens game in London. Twitter held the rights to live stream Thursday Night Football games in 2016.

Patriots vs. Buccaneers: Picks, predictions, odds, point spread

Per Bovada, the Patriots opened as six-point favorites over the Buccaneers, and that spread remained intact as of Thursday morning. The over/under points total was set at 55.

SN's Vinnie Iyer in his Week 5 NFL picks against the spread picked the Patriots to beat the Buccaneers and cover the spread, 34-27.

SN's David Steele in his Week 5 NFL picks straight up went the other way and picked the Buccaneers to upset the Patriots in a close game, 31-29.