This work was supported by NIH grant CA R01CA165065 to D.I.G. and V.E.K., NIH grant AI110485 to M.B., and by animal, genomics and flow cytometry core facilities of the Wistar Institute. We thank R. Schreiber for providing us with F244 cells; L. Joannas and J. Henao-Meja for generating Slc27a2fl/fl mice; W. Stremmel for providing Slc27a4fl/fl mice; and D. Weiner for providing tetramers.

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Nature thanks Andreas Stahl, Judith Varner and the other anonymous reviewer(s) for their contribution to the peer review of this work.