Matthew Stafford threw for two touchdowns, rookie Jamal Agnew broke the game open with an 88-yard punt return in the fourth quarter and the Detroit Lions beat the New York Giants 24-10 on Monday night.

The Lions (2-0) sacked Eli Manning five times and Stafford put together another big game while sending the Giants (0-2) to a second straight disappointing performance in a season where so much was expected. Star receiver Odell Beckham Jr returned from a sprained left ankle, but New York still struggled offensively.

Stafford found Marvin Jones for a 27-yard touchdown in the first quarter and passed to Eric Ebron for a go-ahead seven-yarder in the second. Matt Prater added a 56-yard field goal just before halftime that bounced off and over the upright, helping the Lions to a 17-7 lead at the break.

Ezekiel Ansah had three sacks as Detroit joined Atlanta and Carolina as the only unbeaten teams in the NFC through Week 2.

Beckham, a three-time Pro Bowler who missed the season opener, had four catches for 36 yards in limited action.

Manning threw an 18-yard touchdown pass to Evan Engram on the first play of the second quarter, but the rookie tight end was called for unsportsmanlike conduct for a seemingly obscene gesture. It allowed the Lions to get the ball at the Giants 45 after the kickoff went out of bounds and Stafford drove them for a second score.

New York closed to 17-10 on Aldrick Rosas’ 25-yard field goal early in the second half, but it wasted a chance for a TD. The Giants had first-and-goal at the 1 and then got pushed back to the 11 on a holding penalty on a first-down run.

Agnew then helped clinch the game for Detroit with his big return with 12:56 left, faking out New York punter Brad Wing on his way to the end zone. It was the fifth-longest punt return in team history.

Manning was 22 for 32 for 239 yards for New York, while Stafford was 15 for 21 for 122 yards. Stafford also threw for four touchdowns in Detroit’s season-opening victory against Arizona.