Lionsgate has set drug trafficking drama “Sicario,” starring Emily Blunt, Benicio Del Toro, Josh Brolin and Jon Bernthal, for a Sept. 18 limited release followed by a wide release on Sept. 25.

“Prisoners” helmer Denis Villeneuve directed from a script by Taylor Sheridan.

Producers are Basil Iwanyk, Molly Smith, Trent Luckinbill, Thad Luckinbill and Edward McDonnell. Production companies are Black Label Media and Iwanyk’s Thunder Road Pictures.

The story, set in the lawless border area between the U.S. and Mexico, centers on an idealistic FBI agent (portrayed by Blunt) being exposed to the brutal world of international drug trafficking by members of a government task force — played by Brolin and Del Toro — who have enlisted her in their plan to take out a Mexican cartel boss.

“Sicario” is the fourth wide release title set for Sept. 25 after Sony’s “Hotel Transylvania 2,” Relativity’s horror thriller “The Disappointments Room” and Warner Bros. comedy “The Intern.”