Thirty-three medical professionals who flew from South America to Sydney after going on a cruise ignored quarantine orders and got on a domestic Australian flight, police say.

The large group of medics had been aboard the Roald Amundsen and Scenic Eclipse Antarctic cruises before they flew into Australia from Chile.

Despite police telling them they had to quarantine at hotels for two weeks after arriving from overseas, the 33 went to the domestic departures terminal and tried to leave.

The large group of medics had been aboard the Roald Amundsen and Scenic Eclipse Antarctic cruises (pictured) before they flew into Australia from Chile

Passengers are seen arriving at Sydney International Airport on Saturday night

Twenty-seven flew interstate, while police caught up with the other six before they were able to leave, the Sydney Morning Herald reported.

The group were among 290 people on board the flight from Santiago to Sydne yon Friday night.

From today, all passengers arriving in Australia will be required to quarantine at designated hotels for two weeks.

Police Minister David Elliott was 'disappointed to hear medical professionals chose to ignore rules in place to save lives and protect the most vulnerable in our community'.

He added that 'no one is above the law'.