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Five immigrants have been killed and several others injured after their vehicle crashed while being chased by US Border Patrol agents in Texas.

Some of the injured were thrown from the Chevy Suburban SUV, which was packed with 14 people and travelling up to 100 miles per hour, when it crashed 90 north of the Mexican border.

"The vehicle ran off the road and caught gravel and then tried to recorrect and then caused the vehicle to turn over several times," Dimmit County Sheriff Marion Boyd told CNN.

"We've seen this many, many times, in not only this county but other counties along the border.

"This is a perfect example of why our borders need to be secure."

(Image: CBS) (Image: ABC)

Some of the victims were flown by helicopter to San Antonio for medical treatment.

Border Patrol agents attempted to stop the vehicle when the chase ensued and were soon joined by Dimmit County deputies, KFDM reported.

TV images showed the smashed vehicle missing at least two wheels, with debris strewn across the road at the Big Wells city limit.

(Image: CBS) (Image: ABC)

Four people died at the scene and a fifth died later, San Antonio's KSAT 12 television reported.

The driver was arrested by Homeland Security officials, KSAT reported, citing unnamed officials.