The San Francisco 49ers and Detroit Lions will face off at Levi's Stadium in Santa Clara, California on Sunday afternoon (1:05 p.m. PT) in a game where both teams will be looking to rebound from disappointing season openers.

The 49ers will be looking to avoid the mistakes that plagued them in a 24-16 road loss to the Minnesota Vikings, while the Lions are looking to regroup after a 48-17 shellacking at home on Monday Night Football to the New York Jets. The latter of those two results seems to have left an impression with national prognosticators, who are mostly picking the 49ers to be the team that comes away with a win.

Working against the Lions is the fact they have to fly to the West Coast to play on a short week, but they have an experienced quarterback in Matthew Stafford who is capable of leading them to a win in this game.

The 49ers will have the benefit of playing in front of a home crowd, where they won their final two games of the season in 2017 with quarterback Jimmy Garoppolo at the controls. Garoppolo and the 49ers will be looking to recapture some of that magic this week.

Read on for a rundown of what the national prognosticators are saying about the 49ers-Lions matchup.

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