A terror attack claimed by the Islamic State targeted Barcelona's most famous street on Thursday, killing at least 13 people and injuring more than 100.

A van drove into pedestrians on the Las Ramblas avenue, a top tourist destination, jumping the sidewalk around 5:30 p.m. local time. Of the wounded, at least 15 people sustained serious injuries, Spain's interior ministry said in a press conference.

The perpetrators are soldiers of the Islamic State, the terror network's Amaq news agency has said. Two men have been arrested, Spanish authorities said, but neither detainee is the suspected driver of the van, who reportedly escaped on foot.

@mossos: The two detainees are related to the attack in #Barcelona, but they are not the driver of the van #MajorTrapero #barcelonaattack

The vehicular assault was related to a Wednesday night explosion in Alcanar, an area south of Barcelona, the interior ministry said. Residents of a house in Alcanar were preparing explosives with gas cylinders when an explosion killed one person and injured six others, police told Reuters.

Hours following Thursday's van incident, Catalan police said that they killed five alleged terrorists in the town of Cambrils. The terrorists were linked to events in Barcelona and Alcanar, police said.