A senior military aide to Iranian Supreme Leader Ali Khamenei predicted that the United States would “disintegrate” within the next quarter-century.

“The US has reached a point today that it will witness fragmentation and disintegration 25 years later,” General Nasser Arasteh was quoted as saying Friday night by the semi-official Fars news agency.

The remark recalled comments by Khamenei himself, who predicted last year that Israel would not survive the next 25 years.

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“You will not see next 25 years,” a tweet by Khamenei’s official Twitter account said in September, adding that the Jewish state would be hounded until it was destroyed.

On Friday, a resolution issued in Iran to mark the anti-Israel al-Quds Day openly called for the elimination of “the cancerous tumor of Israel,” and declared that “noble cause” as the top priority for the Muslim world.

The text of the resolution was published by Fars, which said it was adopted by the vast numbers of Iranians who took to the streets across the country to demonstrate against Israel and its allies, including the United States.

“We Iranians as a united and integrated nation see liberation of the Holy Quds (Jerusalem), rescuing the oppressed and defenseless Palestinian nation from the dominance of the fake Zionist regime, and efforts aimed at eliminating the cancerous tumor of Israel as the noble cause of the Islamic Revolution,” Fars quoted the resolution as saying. This goal is the “first priority of the Muslim World and the only way to confront the illegitimate and criminal Zionist regime,” the text continued.

The resolution also urged Muslims worldwide not to allow “the enemies of Islam” to distract their attention from the issue of the Holy Quds and Palestine, Fars said.

The text was published as Iranians staged anti-Israel rallies across the country for the annual al-Quds Day events, a tradition established by the late ayatollah Ruhollah Khomeini on the last Friday of Ramadan. Some protesters trampled the Israeli flag, and also chanted “down with the USA.”

President Hassan Rouhani, attending the Tehran rally, said regional conflicts were making it increasingly difficult to address the Palestinian issue. “Today, due to the divisions in the Islamic world, the presence of takfiris (Sunni extremists) and terrorists in the region… we are far away from the ideal of liberating Palestine,” he told state TV, calling for greater unity between Muslims.

“The Zionist regime (Israel) is a regional base for America and the global arrogance (the US and its allies),” he added. “Disunity and discord among Muslim and terrorist groups in the region … have diverted us from the important issue of Palestine,” Rouhani said. “Unity is the only way to restore stability in the region,” Rouhani further said. “We stand with the dispossessed Palestinian nation.”

Iran, which does not recognize Israel and calls for its destruction, has marked al-Quds Day since the start of its 1979 Islamic revolution. Al-Quds is the historic Arabic name for Jerusalem, and Iran says the day is an occasion to express support for the Palestinians and emphasize the importance of Jerusalem for Muslims.

Agencies contributed to this report.