Queensland Ambulance were called to Southport State High School on the Gold Coast three separate times after the teenage girls overdosed on what is believed to be prescription medication.

Students told 7 News they overdosed on Xanax and it’s not known if the girls took the drug together or at different times throughout the day.

The first call to Queensland Ambulance Service was made at 8.30am when one girl fell ill.

View photos Queensland Ambulance paramedics were called to Southport State High School after drug overdoses. Source: Google Maps/file More

By 12.15pm paramedics had returned to the school after two other girls became sick.

The final call came at 1.30pm when the fourth girl fell ill, a Queensland Ambulance Service spokesman said.

The four girls were taken to Gold Coast University hospital and are all in a stable condition. The hospital told Yahoo7 News two of the girls have since been released earlier today while two remain in hospital.

While the hospital were unable to give the girls’ ages, a spokesperson said the girls involved were “young teens”.

View photos An ambulance arrives at the hospital on Friday. Source: 7News More

The Queensland Department of Education confirmed the incident in a statement.

“Due to student privacy issues, no further details can be provided,” it said.

“The health and wellbeing of students is the department’s highest priority and the school will continue to work with authorities as the incident is investigated.”

The incident has been reported to police.

The school says it will continue to work with authorities while the investigation continues.

Queensland Police told Yahoo News the Gold Coast Child Protection and Investigation Unit are investigating the incident.

With AAP