A 33-year-old truckie has been charged after more than $140 million worth of cocaine and MDMA was found hidden in a shampoo shipment from Spain.

Police say the massive seizure was destined for the streets of regional NSW.

Watch the video above.

Australian Border Force officers swooped on a shipment of shampoo from Spain, uncovering more than 300kg of cocaine and 236kg of MDMA earlier this month.

Hidden inside the shipment were 49 boxes containing bags of a brown crystalline substance and blocks of white powder.

The packages contained 312kg of cocaine worth $93.6 million on the street and 236kg of MDMA worth $47.2 million, police said.

The total value of the seizure was more than $140 million.

Detectives from the NSWPF Organised Crime Squad, ABF investigators and the NSW Crime Commission, with assistance from the Australian Federal Police, established Strike Force Bresnahan to investigate the suspicious import.

Following extensive inquiries, investigators searched storage facilities in Cromer, Brookvale, Chatswood, Artarmon, and Macquarie Park on Monday.

Police say the drugs have an estimated street value of $140 million. Credit: Australian Border Force/NSW Police

A 33-year-old truck driver from the Maitland area has been charged with two counts of possessing a prohibited drug after he was arrested outside one of the facilities at Cromer about 10am on Monday.

It's alleged he was also found in possession of an encrypted telecommunications service.

Detectives searched storage facilities in Cromer, Brookvale, Chatswood, Artarmon, and Macquarie Park on Monday and seized items.

Play Video The NSW Police Force and Australian Border Force have intercepted large quantities of illicit drugs. The NSW Police Force and Australian Border Force have intercepted large quantities of illicit drugs.

Drugs bound for regional NSW

Stuart Smith, Acting Commander of the State Crime Command, says police will allege the shipment was bound for regional NSW.

"We think this was headed to regional NSW directly, which is probably the first time we've seen such a significant seizure for regional NSW," Smith told reporters on Tuesday.

He said the truck that turned up to collect the drugs was from the Maitland area "but has links to as far out as Tamworth and the western region".

The trucking company which the accused works for is now under investigation.