For the second time in four seasons, health issues are sidelining Trail Blazers’ radio voice Brian Wheeler.

Wheeler, 55, will miss Friday’s exhibition finale at the Moda Center, then at least the first three games of the regular season as he battles scrotal lymphedema. The condition, which caused him to miss four games in November of 2013, has returned and made it painful for him to sit through a broadcast, Wheeler said.

“I’m in a lot of discomfort,’’ Wheeler said after calling Wednesday’s game at Phoenix. “The hard part is the condition has now made it somewhat painful just to sit for extended periods, such as the length of a game. The entire preseason I was standing during every timeout by the third quarter … to no avail.’’

Scott Lynn, a former Portland radio and television personality who now lives in Florida, will fill in for Wheeler for the opening games of the season at Phoenix, Indianapolis and Milwaukee.

Wheeler, who is in his 20th season with the Blazers, said he noticed the condition returning in July and tried to address it before the season, but could never get the proper treatment.

“I pride myself in being ready for every broadcast,’’ Wheeler said. “So I hate missing even one game.’’

Wheeler said he reluctantly agreed to the leave of absence, and said he hopes it is only for the opening trip of the season.

He said he will begin a low-calorie, medically-supervised diet in hopes of losing weight and alleviating the condition.

“I’m hoping it will be a short time away,’’ Wheeler said.

When Wheeler missed games in 2013, it broke his streak of 1,359 consecutive broadcasts, which spanned 16 seasons. In September, he signed a multi-year extension with the team.

“I love my job and the people I work with; I feel I’m letting them down in some ways,’’ Wheeler said. “The team was kind enough to give me an extension so I could continue doing what I enjoy the most. I owe it to them and all the loyal listeners to be at my best, and I can assure everyone, I will be as soon as possible.’’