Denver Health medical center is facing a sudden exodus of neurosurgeons.

Hospital chief Arthur Gonzalez confirmed Wednesday that three neurosurgeons will be gone by the end of this month.

“We have five neurosurgeons,” he said. “We had one who resigned two weeks ago. We had two who resigned (Tuesday).”

Gonzalez said he could not comment immediately on the status of the remaining two, because one was in surgery and the other is out of the country.

Hospital spokeswoman Kelli Christensen said the remaining two “have not notified the hospital of any intention to leave.”

Denver Health is a Level I trauma center known for its service to indigent patients, as well as the insured. Gonzalez expressed confidence that its neurosurgeons’ departure would not affect patient care.

In the short run, “we are reaching out to other organizations” with neurosurgeons, including the University of Colorado, “while we look for more long-term solutions,” he said.

Neurosurgeons specialize in the diagnosis and surgical treatment of disorders of the nervous system, including the brain and spine.

Gonzalez noted that all of the departing doctors gave advance notice, and the two who quit Tuesday will stay at the hospital until April 1.

He said he could not comment specifically about their reasons for leaving, but they involved concerns “as a result of some of the changes that have to be done” in a new medical care environment.

“Health care’s going through a tough time,” he said.

Gonzalez said he had notified the hospital’s board of directors of the neurologists’ decision.

“We have 30 days, and we’re confident we’ll have it fixed by that time,” he said. “We’ll be fine.”

Rus Heise, a retired investment banker who chairs the hospital’s board of directors, said the first neurosurgeon who left is nearing retirement and the other two provided ample notice.

He said patients have no reason to fear gaps in the hospital’s level of care.

“Our concern is patient access and patient safety,” he said. “We take care of thousands of people every day. It’s not going to be any different tomorrow.”

The Denver Post reported in January that Denver Health had lost other top doctors, including its chiefs of medicine and surgery.

Gonzalez said the hospital has two final candidates for the surgery position and numerous applicants for chief of medicine.

“Denver Health is an attractive place,” he said.