Update, 11 a.m.: This round is closed, please stand by for the next round.

How are you guys going to decide between couples like these?!

We're down to the Sweet 16, and we've got matchups like House & Cuddy from House versus Meredith & Derek from Grey's Anatomy, Glee's beloved Brittana versus Fringe's Peter & Olivia, and Castle & Beckett from Castle versus The Vampire Diaries' Delena.

Already know who you want to win? Then get voting!