"Late Night" host Seth Meyers on Tuesday weighed in on Secretary of State Rex Tillerson Rex Wayne TillersonGary Cohn: 'I haven't made up my mind' on vote for president in November Kushner says 'Alice in Wonderland' describes Trump presidency: Woodward book Conspicuous by their absence from the Republican Convention MORE's ouster, suggesting that President Trump Donald John TrumpBiden leads Trump by 36 points nationally among Latinos: poll Trump dismisses climate change role in fires, says Newsom needs to manage forest better Jimmy Kimmel hits Trump for rallies while hosting Emmy Awards MORE should have fired Education Secretary Betsy DeVos Elizabeth (Betsy) Dee DeVosNEA president says Azar and DeVos should resign over school reopening guidance The Hill's 12:30 Report - Presented by Facebook - You might want to download TikTok now Former DeVos chief of staff joins anti-Trump group MORE instead.

“If you are going to fire Cabinet secretaries for being bad at their jobs, let me refer you to Betsy DeVos’s appearance on ‘60 Minutes,’ ” Meyers said on Tuesday night. “Not only was she wildly uninformed but 60 minutes was also her longest work day so far.”

The comedian's comment was a reference to an interview DeVos did with CBS's "60 Minutes" on Sunday night, in which the Education secretary struggled to answer basic questions regarding schools in her home state of Michigan. The interview drew ridicule on social media and led DeVos on Tuesday to suggest the news program had purposely edited the interview to make her look bad.

Meyers's comment on Tuesday night came during a segment in which he poked fun at Trump for removing Tillerson via Twitter earlier that day. The comedian said that Tillerson’s ouster and the resignation of Trump’s economic adviser Gary Cohn hopefully mark the “end of this myth that serious people can rein in Donald Trump.”

Meyers also jabbed Tillerson, saying that if the White House was a fraternity in an '80s movie Tillerson would be the dean.

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“And the dean never wins in an '80s movie,” Meyers said.

Trump removed Tillerson on Tuesday and announced CIA Director Mike Pompeo Michael (Mike) Richard PompeoUS reimposes UN sanctions on Iran amid increasing tensions Sunday shows preview: Justice Ginsburg dies, sparking partisan battle over vacancy before election Trump steps up Iran fight in final election stretch MORE would be taking the helm of the State Department.

Cohn, a supporter of free trade, said he would leave the White House after Trump announced he would be imposing tariffs on imported steel and aluminum.

Tillerson’s ouster had been rumored for months, as Trump and Tillerson rarely seemed to be on the same page concerning the White House’s foreign policy, but the news still came as a shock to most in Washington.

The president said his decision was based on disagreements with Tillerson that included diplomacy with North Korea, the announced tariffs and the Iran nuclear deal.