MANILA — With many roads and bridges washed away, rescue teams struggled Wednesday to reach isolated villages in the southern Philippines after a powerful out-of-season typhoon tore through the region, leaving at least 325 people dead and several hundred more missing, officials said.

Typhoon Bopha packed winds of up to 100 miles per hour when it struck Tuesday, bringing torrential rains that destroyed villages and left thousands homeless.

The deaths were concentrated in the province of Compostela Valley, a mountainous gold mining area, and the neighboring province of Davao Oriental, on the eastern coast of the southern Philippine island of Mindanao, Lt. Col. Lyndon Paniza, a military spokesman, said in a telephone interview late Wednesday afternoon.

The Office of Civil Defense reported Thursday morning that the death toll had risen to at least 325, and rescuers were searching through mud and debris for 379 people reported missing, according to The Associated Press.