A 22-year-old woman has died in hospital after being doused in petrol and set alight at a home in Melbourne’s south-east.

Emergency services found the injured woman when they were called to the Boronia Avenue, Cranbourne, property on Saturday night.

She was taken to Alfred Hospital in a serious condition and had skin grafts applied to her head, back and shoulders.

The woman was found about 6.30pm Saturday. (9NEWS)

Police confirmed she died in hospital this morning.

The victim’s estranged 29-year-old husband remains in custody, where he is assisting police with their inquiries.

No charges have been laid.

The exact circumstances regarding the incident are still to be determined,” police said in a statement today.

Police investigations are ongoing. (9NEWS)

Circumstances surrounding the incident remain undetermined, police said. (9NEWS)

It is believed the woman lived with her in-laws and a one-year-old child.

"They're a pretty quiet bunch, you never really hear any noises or hear any disturbances," a neighbour told 9NEWS on Sunday.

Another neighbour, Daniel McCreedy, said that he found the woman burnt after hearing loud scream.

Neighbour Daniel McCreedy told 9NEWS following the incident. (9NEWS)

"It was quite distressing. We found a jerry can in the backyard on fire, which we put out, and then just proceeded to try and look after them."

The trashed backyard led to a bathroom inside where Mr McCreedy helped the woman's family extinguish the flames.