Story highlights Bill Cosby makes drinking comment to woman during his London, Ontario, show

Heckler escorted out after person yelled "Bill Cosby you're a rapist"

Group of protestors showed up outside the venue

Cosby received his second standing ovation in as many nights

(CNN) In a rare reference to the sexual assault allegations against him, Bill Cosby told a woman attending his comedy show that, "you have to be careful about drinking around me."

The comment came during an otherwise lighthearted moment in his standup show Thursday night in London, Ontario, as a woman near the front row got up to go get a drink and Cosby asked her where she was going.

The remark is likely to anger his accusers who have demanded he respond to the allegations of sexual abuse against him.

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Minutes after that incident a heckler was ejected from the performance by police after yelling 'Bill Cosby you're a rapist'. During the incident Cosby did not confront the man and encouraged the audience to remain calm and patient. He resumed his comedy show within a few minutes.

In a statement released through his public relations firm Cosby says, "One outburst but over 2600 loyal, patient and courageous fans enjoyed the most wonderful medicine that exist for human-kind. Laughter. I thank you, the theatre staff (Budweiser Gardens), the event organizers and the London, ON Community for your continued honor and support. I'm Far From Finished."

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