BOSTON -- Dustin Pedroia left Thursday's game vs. the Rangers with knee pain after five innings.

And he's not in Friday's lineup against the Seattle Mariners here at Fenway Park.

Andrew Benintendi is batting second where Pedroia typically bats. Hanley Ramirez has taken Benintendi's cleanup spot.

Josh Rutledge is playing second base.

Eduardo Rodriguez will start for the Red Sox. The lefty allowed just one run, three hits and two walks while striking out six over 6 1/3 innings for Boston against Seattle at Safeco Field last Aug. 1. He allowed just one hit over the first five innings.

RED SOX LINEUP

1. Mookie Betts RF

2. Andrew Benintendi LF

3. Xander Bogaerts SS

4. Hanley Ramirez DH

5. Mitch Moreland 1B

6. Josh Rutledge 2B

7. Jackie Bradley Jr CF

8. Christian Vazquez C

9. Deven Marrero 3B

Pitching matchup: LHP Eduardo Rodriguez (3-1, 3.10) vs. RHP Yovani Gallardo (2-4, 5.84)