"It's $200 billion of actual spending, enhanced by private capital and municipal spending. Munis aren't really in a position to do that. It sounds better on paper than it is in practice," said George Goncalves, head of fixed income strategy at Nomura.

One is that the president's plan to spend on infrastructure could end up increasing the national debt. The U.S. is already expected to double the size of its debt issuance this year, to nearly $1 trillion, and that is a factor that's been weighing on Treasury prices, which move opposite yields.

The first is President Donald Trump 's State of the Union address Tuesday evening. Bond strategists say there are several risk factors associated with it.

The jump in interest rates to four-year highs is the biggest catalyst behind the stock market's sell-off, and there are three big events that could send those rates even higher in the next 24 hours.

Trump, in the State of the Union, called on Congress to advance a $1.5 trillion plan to "rebuild our crumbling infrastructure," and federal appropriations should be leveraged by partnering with state and local governments and tapping the private sector.

Treasury yields slipped slightly after the speech, with the 10-year Treasury yield at 2.70 percent, down from Tuesday's 2.72 percent.Yields move opposite price.

The second event and the one strategists see as the biggest wild card, is the Treasury's refunding announcement, scheduled for 8:30 a.m. ET Wednesday. It will include details on the first-quarter Treasury auctions and possibly on other funding needs for 2018.

The government's bigger debt requirement is the result of more spending from the tax cuts and also an increase in entitlement spending. While usually a minor event, this week everyone in markets is watching the refunding announcement.

"That's huge. There's a lot of talk about that. We differ from the consensus so we think supply is at least going to pickup in the very long end, the 30-year bond. A lot of people think there will only be increases in the short end," said Michael Schumacher, director of rates at Wells Fargo.

John Briggs, NatWest Markets head of strategy, said he expects the auction size for 10-year notes and 30-year bonds to increase by $1 billion each, but any surprise could cause Treasury yields to move. He said the announcement should add supply across the curve, meaning an increase in Treasury bills at the short end all the way to the 30-year bond at at the long end.

The 10-year Treasury yield was at 2.72 percent in afternoon trading Tuesday, a big move from the 2.40 percent at the end of December. The 30-year was close to crossing the psychological 3 percent threshold.

When interest rates rise, they can become a challenge for stocks because they offer higher yielding investment alternatives and also make for higher borrowing costs for corporations. The closely watched benchmark 10-year Treasury yield impacts a whole range of borrowing rates from small business loans to home mortgages.

Goncalves said the government funding announcement will be important, particularly since it comes after the State of the Union focus on spending.

"Wednesday morning we may wake up and realize there's more debt coming down the road. Then we see the government estimates for its borrowing needs," he said. "That could be the one-two punch that brings us to near-term highs in rates for at least the week and maybe for the next month."

The final event is normally the one that would have the most potential to be market moving, but it is not expected to have much impact this week. The Federal Reserve meeting, underway Tuesday, concludes Wednesday and the Fed issues its statement at 2 p.m. ET.

While the central bank is not expected to raise rates at Fed Chair Janet Yellen's final meeting, it could indicate that the economy is improving and comment on inflation, which is running below its target.

But in the run-up to the meeting, the market is also beginning to expect a fourth rate hike for this year on top of the three the Fed is currently forecasting. If the statement sounds hawkish, that could pressure shorter-term rates, like the two-year. On Tuesday the was at 2.12 percent.

"I feel like we have this crescendo moment if everything lines up like I suspect," said Goncalves.

There are other factors impacting bond yields this week, including Friday's jobs report, which could drive yields higher if wages rise more than expected.

"Technically, the charts show rates are stretched, and they're due for a pullback. We have month end which will coincide with the day after the president's speech," Goncalves said.