Effects of LSD on the 5D-ASC scale. The data are derived from three studies using doses of 75 μg i.v. (Carhart-Harris et al, 2016b), 100 μg p.o. (Liechti et al, 2017), and 200 μg p.o. (Schmid et al, 2015) LSD in healthy subjects. LSD predominantly increased ratings in subscales of the dimensions oceanic boundlessness and visionary restructuralization. LSD-induced increases in subscales of the anxious ego-dissolution dimension and in particular in the anxiety scale were relatively small. LSD-induced changes on the 5D-ASC scale were significant compared with placebo for all LSD doses and all of the scales, with the exception of the effects of the 200 μg dose on anxiety. There were no statistical differences in the effects of the intravenous 75 μg (Carhart-Harris et al, 2016b) and oral 100 μg (Liechti et al, 2017) dose of LSD on 5D-ASC scale ratings (data provided by the authors). At 200 μg, LSD produced significant and relevantly higher ratings of blissful state, insightfulness, and changed meaning of percepts compared with 100 μg. The data are expressed as the mean in 24, 16, and 20 subjects for the 100 μg, 200 μg, and 75 μg doses of LSD, respectively.

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