Abstract

Background No study has examined dopamine D 2/3 receptor (D 2/3 R) availability in antipsychotic-free older patients with schizophrenia.

Methods We included patients with schizophrenia 50 years or older who were antipsychotic-free for at least 3 months. We compared non-displaceable binding potential (BP ND ) of [11C]-raclopride in the caudate, putamen, ventral striatum, and globus pallidus between patients and age- and sex-matched healthy controls.

Results Ten patients participated (antipsychotic-naive = 4). No differences in BP ND were found between patients and controls in any ROIs (F(1, 72) = .42, p = .52).