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Merck Research Laboratories, 126 East Lincoln Avenue, RY33-500, Rahway, NJ 07065, USA.

Page(s) : 32-7

32-7 Année de parution : 2002

Male pattern hair loss (MPHL) affects 50% of men by the age of 50 [1, 2]. This condition is thought to be under genetic control, occurring in males with an inherited sensitivity of scalp hair follicles to the deleterious effects of androgens [3, 4]. Subjects with a defect in the enzyme 5*-reductase (5*R) type 2, which converts testosterone into dihydrotestosterone (DHT), do not develop MPHL, suggesting that this condition can be prevented [...]