Donald Trump Donald John TrumpObama calls on Senate not to fill Ginsburg's vacancy until after election Planned Parenthood: 'The fate of our rights' depends on Ginsburg replacement Progressive group to spend M in ad campaign on Supreme Court vacancy MORE said in his victory speech Tuesday night that Hillary Clinton Hillary Diane Rodham ClintonWhat Senate Republicans have said about election-year Supreme Court vacancies Bipartisan praise pours in after Ginsburg's death Trump carries on with rally, unaware of Ginsburg's death MORE wouldn't get 5 percent of the vote in a general election if she were a man.

"Frankly, if Hillary Clinton were a man, I don't think she'd get 5 percent of the vote," the GOP presidential front-runner told a crowd gathered at Trump Tower in New York for his victory speech after the billionaire swept all five of Tuesday's East Coast primaries.

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"The only thing she's got going is the woman's card," Trump added, in an extended attack on the Democratic front-runner toward the end of his speech.

"And the beautiful thing is that women don't like her. ... And look at how well I did with women tonight."

Clinton responded to Trump's "woman card" remark on Twitter Tuesday night.

Trump quickly pivoted from the primary to the general election and went after Clinton aggressively in his remarks.

"Hillary does not have the strength or stamina to deal with China or other things," Trump added.

Trump knocked the former secretary of State on women's issues and blasted her 2002 vote for the Iraq War.

"I’ll do far more for women than Hillary Clinton will do," he said.

"She will not be good with a military. She had her shot, and she raised her hand when it came to Iraq," he added.

"She's a flawed candidate," Trump said. "I think she's going to be much easier to beat than most of the 16 people I competed with."

On Tuesday, Trump notched victories in Delaware, Rhode Island, Maryland, Pennsylvania and Connecticut, bringing the real estate mogul closer to the 1,237 delegates he needs to win the party's nomination before the Republican National Convention in July.