Republicans are seizing on Democratic demands for a single-payer health-care system as an attack line in California, arguing that candidates backing the issue spearheaded by Sen. Bernie Sanders Bernie SandersOutrage erupts over Breonna Taylor grand jury ruling Dimon: Wealth tax 'almost impossible to do' Grand jury charges no officers in Breonna Taylor death MORE (I-Vt.) are out of step with their districts.

“My opponent wants socialized medicine and government-run health care,” Rep. Mimi Walters (Calif.), a GOP incumbent and top Democratic target, told The Hill. “The district does not support it.”

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Walters represents one of seven GOP-held seats in California that Democratic presidential nominee Hillary Clinton Hillary Diane Rodham ClintonDemocratic groups using Bloomberg money to launch M in Spanish language ads in Florida The Hill's Campaign Report: Presidential polls tighten weeks out from Election Day More than 50 Latino faith leaders endorse Biden MORE won in 2016 that Democrats are seeking to flip. If Republicans lose those seats, it would greatly increase the chances that the GOP loses the House majority.

Republicans say that Democratic candidates might have done well running on “Medicare for all” in crowded primaries, when they needed to move to the left. But they say that position will be a major drag in a general election decided by more centrist voters.

“The anger of the Democratic base against the president is pushing the party aggressively leftward,” said Michael Steel, a Republican strategist and former aide to Speaker John Boehner John Andrew BoehnerLongtime House parliamentarian to step down Five things we learned from this year's primaries Bad blood between Pelosi, Meadows complicates coronavirus talks MORE (R-Ohio). “That’s going to leave them with a lot of candidates who aren’t a good fit for their districts.”

In the seven Clinton-won districts in California, at least five will have Democrats on the November ballot who support single-payer.

They include Josh Harder, who’s expected to challenge Rep. Jeff Denham Jeffrey (Jeff) John DenhamBottom line Bottom line Lobbying world MORE (R) in the Central Valley; Katie Hill, who is running for Rep. Steve Knight’s (R) seat in northern Los Angeles County; Katie Porter, who’s challenging Walters in her Orange County district; and Mike Levin, who’s running to succeed retiring Rep. Darrell Issa Darrell Edward IssaDCCC reserves new ad buys in competitive districts, adds new members to 'Red to Blue' program Wife of former Rep. Duncan Hunter sentenced to 8 months of home confinement Harris endorses Democrat in tight California House race MORE (R) in San Diego County.

Most of those races are considered to be toss-ups by nonpartisan election handicapper Cook Political Report, while Walters's seat is rated lean Republican. Cook moved Issa’s open-seat race from toss-up to lean Democrat days after the California primaries.

Democrats also hope to defeat Rep. Dana Rohrabacher Dana Tyrone RohrabacherDemocrat Harley Rouda advances in California House primary Lawyers to seek asylum for Assange in France: report Rohrabacher tells Yahoo he discussed pardon with Assange for proof Russia didn't hack DNC email MORE (R-Calif.), who has held his Orange County district for 15 terms. As of Friday afternoon, stem cell researcher Hans Keirstead was up 129 votes over businessman Harley Rouda for the second spot on the November ballot. Both Democrats back Medicare for all.

Porter, who defeated a more moderate Democrat in the primary, pushed back on the idea that her support for a single-payer health-care system will hurt her in November.

“The status quo in our health-care system is broken and people know,” said Porter, who was endorsed by Sens. Elizabeth Warren Elizabeth WarrenDimon: Wealth tax 'almost impossible to do' CNN's Don Lemon: 'Blow up the entire system' remark taken out of context Democrats shoot down talk of expanding Supreme Court MORE (D-Mass.) and Kamala Harris Kamala HarrisHarris faces pivotal moment with Supreme Court battle Nearly 40 Democratic senators call for climate change questions in debates Joe Biden has long forgotten North Carolina: Today's visit is too late MORE (D-Calif.). “Washington does not need more can’t-do Democrats.”

Democrats generally think the issue of health care will help them in November.

They are emphasizing the GOP’s opposition to ObamaCare, arguing efforts by President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE and his party to repeal and replace the law has led to rising premiums and higher health-care costs for Americans.

Every California Republican in the House voted to repeal ObamaCare.

“If Republicans wage this election on health care, that’s an argument that Democrats win,” said Mac Zilber, a Democratic strategist in California.

“[Medicare for all favorability] might not be as clean and as pretty as it looks right now, but ultimately if you’re about expanding access versus taking away access, I think that’s exactly the battlefield that Democrats want to be on,” he added.

But not everyone is so certain the issue will be such a winner.

Rob Pyers, research director at California Target Book, which does nonpartisan political analysis in the state, noted that the California House districts that Democrats are seeking to take back from the GOP are all “somewhat conservative” and that Sanders won none of them during the 2016 Democratic presidential primary.

“I wouldn't be surprised to see the [National Republican Congressional Committee] and Mimi Walters pummeling Porter on the airwaves over [single-payer] and a host of her other positions,” he said, referring to the House Republicans’ campaign arm. “In a few months, I'm guessing voters there will be confused as to whether Mimi Walters is running against Porter or Elizabeth Warren.”

Walters brushes off attacks on her vote to repeal ObamaCare.

“I'm not worried about her,” she said of Porter.

Rohrabacher, who was first elected at the end of Ronald Reagan’s presidency and has served through a changing political culture in his state, sounded a similar note.

“That district isn’t going to support any Democratic candidates that just mouth the liberal left line,” he told The Hill.

He said he had no regrets on his ObamaCare repeal vote.

“My votes reflect what I think is good for America and consistent with my philosophy and it has nothing to do with electability,” he said.

House Republicans have signaled that they plan to take Democrats to task over Medicare for all.

The Congressional Leadership Fund, a super PAC aligned with House GOP leadership, sent press releases following the California primaries targeting Porter's and Hill’s stances on single-payer.

And Republicans quickly seized on House Minority Leader Nancy Pelosi Nancy PelosiHoyer: House should vote on COVID-19 aid — with or without a bipartisan deal Ruth Bader Ginsburg lies in repose at Supreme Court McCarthy threatens motion to oust Pelosi if she moves forward with impeachment MORE’s (D-Calif.) statement from a Thursday press conference that if Democrats retake the House, proposals like Medicare for all should be “evaluated.”

A Democratic strategist familiar with the California races said polling conducted in the swing districts shows that Medicare for all is popular, but acknowledged a GOP messaging campaign could change things.

“It does really well right now, but will that change with millions of dollars of spending in a concerted effort by Republicans to make people feel like Medicare for all means trillions of dollars in tax increases?” the strategist said.

“I don’t think we’ve yet seen the Republican media apparatus really make a concerted effort to demonize Medicare for all the way they did with ObamaCare and when that happens, I think the public opinion is going to change.”