In an interview with Screen Rant, editor Charles Beacham called the Prime one-shot "what sets the landscape for the Inhumans Universe going forward," noting that the issue — written by Royals writer Al Ewing, with art by Ryan Sook — will lay "the groundwork for what things are going to look like in April and May and going forward."

What that means in practice is setting up the different areas each new series will inhabit: Royals will feature the classic "royal family" of the Inhumans as they journey into space to discover more about the origins of their race, with Black Bolt placing the Inhumans ruler in prison in a series Beacham describes as "almost a new genre we're creating right there." Secret Warriors, meanwhile, is a more traditional superhero title set on Earth.

As with the X-Men relaunch, parts of the existing Inhumans line will survive the ResurrXion process; both Ms. Marvel and Moon Girl and Devil Dinosaur — two titles that haven't been mentioned in promotion for the relaunch, although the characters both appear in the new Secret Warriors book — are likely to make it through unscathed, considering their success in collected editions.

Inhumans Prime will be released in comic book stores and digitally in spring 2017.