Posted 22 August 2014 - 02:15 PM

!!!PSA!!! ***Public Service Announcement***

Tianeptine: Proceed With Caution

(This should best perhaps be pinned or hopefully bumped with some insight occasionally for best exposure)

Tianeptine Cautionary Warning: Alert to Proceed With Caution for Those So Engaged With Using Tianeptine or Considering Usage



Tianeptine has been further and further demonstrating what appears to be relatively high tendencies toward tolerance, withdrawals upon cessation, and potential abuse/addiction dynamics. This is even being seem within usage that adheres to therapeutic dosages, as to withdrawals upon cessation and escalation of dosages within some with a tendency toward tolerance or misuse/abuse.



Tianeptine has been demonstrated in the literature to bear mu-opioid agonist activity and indeed may bear closer resemblance to classical opiates in the respect of adverse effects of the aforementioned nature than prior thought. Tianeptine as well may have some overall negative impact on the dopaminergic system, which can have impact within tolerance and addiction potentials.



Certainly at this stage it is not something to perhaps be dismissed as an outright agent that is to best be avoided; however, it would appear that the potentials for these adverse effects are best to be made well known, understood, and respected. Freedom of choice is still the rule as per how we see it at TeamTLR, though within that we are as well vigorous proponents of education/knowledge, personal responsibility, and harm reduction.



Notably, most substances can have worth if they are used with adherence in a manner that can be best integrated for therapeutic/beneficial indications. However, overall Tianeptine appears to have more potential as a substance that simply masks underlying conditions, rather than be one that yields true core benefit of substance. This is is within the theory of some substance are more of a nature to be mind/body/'spirit' trophic (tendency for correcting underlying dysregulated states or enhancing 'normal' states), while others overall are more atrophic in this respect (diminishing core regulatory states). Generally those substances that may 'feel good' or appear to provide 'remedy' in the short-term, but within they do not so much provide real benefit to underlying dysregulation, will have tendencies to outcomes that may be undesirable. Tianeptine, as with most 'therapeutics' released by Big Pharma, appears to be more within the atrophic category. Over time these substance tend to have greater potential to diminish physiological integrity, rather than support and build.



The jury is not as yet out, but the evidence seems to perhaps be gathering to support this may be a substance very well best avoided by those with any tendency toward addictions, and as well for those to be wary that even within therapeutic use there may be some 'potential pitfalls' that one must be aware of. It does not appear to be at all a substance that truly affords a best means to provide benefit for underlying core dysregulation; though if respected and well integrated it can provide worth as an adjunct agent used within a protocol that better tries to address core dysregulated states. For example, for those who are not of an addictive disposition, such may best be of an nature of short-term usage and/or intermittent "as needed" usage, within proper therapeutic guidelines.



Note, many substance that may be 'far from perfect' still can have some true worth, within proper care and application. The difference within some compounds between being a profound poison or profound therapeutic is sometimes of course simply a matter of dose. To note further, within the prevalence of abuse/misuse, there appears a strong possibility for Tianeptine to be given a Scheduled status and perhaps removed from the market. Freedom of choice should always reign above all, however, proper knowledge and education is fundamental to making any decision of an informed and well-considered nature.

Kindly take care to respect all substance.

Best Regards,

VI of TeamTLR



P.S. Please feel free to cut and paste this if you 'inhabit' other forums and groups where such may seem to be of benefit to note such an alert.

Edited by VERITAS INCORRUPTUS, 22 August 2014 - 02:29 PM.