A man has been treated in hospital after he was attacked with his own guitars during a home invasion in inner Sydney last night.

Three men forced their way into the 42-year-old's Surry Hills property around 11:00pm (AEDT) after he responded to a knock at the front door.

Police say the men began attacking the 42-year-old immediately, and that one of them was armed with a knife.

Police spokeswoman Felicity Jenkins said the victim suffered numerous injuries, when the intruders assaulted him with two of his own acoustic guitars.

"The men stole two electric guitars from the premises, as well as a quantity of cash from the man's wallet," she said.

"The injured man was attended to at the scene by Ambulance Paramedics and conveyed to St Vincent's Hospital for treatment to injuries to his face, hands and leg."

Police from Surry Hills Local Area Command have established a crime scene and are asking for any witnesses to come forward.