Easter Sunday has taken a tragic turn, with a young man stabbed to death in Brisbane's south.

A home is tonight a crime scene as detectives launch an investigation.

It is believed three young men attended a home on Metropole Street in Roberson at 3pm today, looking for a man in his 20s.

Three young men attended a home in Roberson, looking for a man in his 20s. (9NEWS) (9news)

The men became involved in an altercation with him.

He has then grabbed a kitchen knife and stabbed one of the intruders multiple times.

His injuries were so severe that he died at the scene before emergency services arrived.

9NEWS understands there are multiple people in police custody. (9NEWS) (9news)

The man who stabbed him also sustained serious injuries and is currently in the Princess Alexandra Hospital.

9NEWS understands there are multiple people in police custody assisting them with their enquiries.

Daniel Bragg from Queensland Police said it was a confronting scene.

Daniel Bragg from Queensland Police said it was a confronting scene. (9NEWS) (9news)

“I do know that it’s a shared-house arrangement,” Mr Bragg said.

“There’s a number of people who live at the residence. Can I say I probably haven’t seen more blood than this for a long time.

“Several of the occupants were covered in blood.”