Donald Trump hasn’t wasted time moving to revive America’s economic growth, with an emphasis on manufacturing. Critics may say the recent Carrier deal, which will save 800 American jobs, is small potatoes, but Mr. Trump’s pledge to reduce regulation is decidedly not. A new analysis confirms that the average industry’s regulatory risk has increased nearly 80% from 2010—and that this burden particularly hurts manufacturing and heavy industry.

The analysis was developed by a small group of quantitative hotshots under the guidance...