The co-hosts of the buzzy new podcast “Call Her Daddy” say there’s a distinct difference between what their male and female fans want to know.

Guys want to learn the best ways to pick up women — and have lots of questions about performing oral sex, said Alexandra Cooper, 24, adding that even the internet is no help.

“For girls, it’s how to talk dirty,” added Sofia Franklyn, 26. “They overthink everything.”

Virtually nothing is off-limits for the two roommates (except Cooper’s former relationship with Mets pitcher Noah Syndergaard) on their weekly show — which spans the conversational gamut from sex acts like the “gluck gluck 9000” to them listening to each other get it on from the next room.

“This is a women’s locker-room conversation that we should be able to have,” said Cooper.

Produced by the controversial website Barstool Sports, “Call Her Daddy” has been a top-10 mainstay on the iTunes comedy chart since just two weeks after its October release. The podcast already has more than 10,000 reviews on iTunes after just 13 episodes, averaging 4.5 out of 5 stars.

“Barstool told us that rarely are there ever podcasts split 50/50 [between] male and female listeners, and that’s what we have,” Cooper told The Post.

The idea for “Call Her Daddy” originated during a vacation at the South by Southwest festival in Austin, Texas, in March, Cooper said. She and Franklyn were at a bar talking candidly about sex — and ­began to attract an audience.

“People came up to us and said ‘You need a show, because I would listen to this every day,’ ” Cooper recalled.

The women, who were introduced by a mutual friend, came back to New York and recorded their first podcast on their own, garnering a full-time job ­offer from Barstool.

The name “Call Her Daddy” refers to how they’re turning the tables on men and taking charge.

Episode 1 kicks off with an explicit account of the previous night, when Cooper and Franklyn got drunk on whiskey in their Lower East Side apartment and exchanged sexy texts with Cooper’s latest fling. When Cooper fell asleep, Franklyn continued the X-rated chat — with the guy still thinking she was her roommate.

‘This is a women’s locker-room conversation that we should be able to have.’

Cooper, who is originally from Newtown, Pa., and played soccer at Boston University, worked in sales at Gotham magazine before joining Barstool. But she’s best known for her relationship with Syndergaard, which was on and off for about a year. (She won’t talk about him and only refers to her “exes” on the show.)

Franklyn — raised in Salt Lake City, Utah — admits the job change was “jarring.” She was working at a “Top 5 financial firm” after graduating with an economics degree from the University of Utah.

“My mother has lost her mind [over it],” Franklyn said in Episode 9. “She told me the other day that she knows Alex and I will be approached to do a porno.”

(Franklyn told The Post, “As time has gone on, everyone has become so supportive of it.”)

Both women are single and, Cooper said, on Raya, the invitation-only dating app reportedly used by celebs including Elijah Wood, Patrick Schwarzenegger and Diplo.

“The cool thing about dating in New York is . . . you have every type of guy to go on a date with,” Franklyn said.

“If you walk into Socialista, you are getting guys that are, like, dressing nicer — suits — and they’re bougie. Or if you go to the local bar, you can find more just-out-of-college guys who are into sports,” Cooper added. “And Sofia and I do both . . . it’s more what we are in the mood for that night.”

But there is one surefire way to fail at picking them up: “[Guys’] go-to line now is, ‘Do you want me to call you Daddy?’ ” Cooper said. “And we’re like, Oh, God.”