Joshua Vogelstein writes:

I know you’ve discussed this on your blog in the past, but I don’t know exactly how you’d answer the following query:

Suppose you run an analysis and obtain a p-value of 10^-300. What would you actually report? I’m fairly confident that I’m not that confident :) I’m guessing: “p-value \approx 0.”

One possibility is to determine the accuracy with this one *could* in theory know, by virtue of the sample size, and say that p-value is less than or equal to that? For example, if I used a Monte Carlo approach to generate the null distribution with 10,000 samples, and I found that the observed value was more extreme than all of the sample values, then I might say that p is less than or equal to 1/10,000.