The San Francisco 49ers go into Week 16 -- in which they can clinch their third playoff berth in three seasons with Jim Harbaugh as coach -- with their 53-man roster in fairly good health.

Left guard Mike Iupati and receiver Mario Manningham are likely the biggest question marks.

Like last week, Iupati was limited all week. He has missed the past four games with a sprained knee. Harbaugh told reporters Saturday that Iupati had a productive week, but no decision has been made whether he will play Monday night against Atlanta. Adam Snyder would continue to play for Iupati if needed.

Manningham, the team's No. 3 receiver, missed Thursday and Saturday’s practices because of an illness and a knee injury. Mannigham has played sparingly in the past three games since Michael Crabtree returned.

Rookie receiver Quinton Patton could be active for the first time since Week 4 if Manningham is inactive.

The 49ers can clinch a playoff berth if Arizona loses at Seattle on Sunday or if the 49ers win Monday night. San Francisco can secure the No. 5 seed in the playoffs if it beats Atlanta and then wins at Arizona on Sunday. San Francisco is 10-4 and has won four straight games.