Melatonin secretion by the pineal gland has been reported to be affected by exposure to electromagnetic fields (EMFs). In an initial investigation to determine if calcifications commonly found in the pineal gland could respond to EMFs by a transducer mechanism, studies were conducted to ascertain if pineal tissues were piezoelectric. Second harmonic generation (SHG) measurements showed that pineal tissues contained noncentrosymmetric crystals, thus proving the presence of piezoelectricity. Both mulberry-like and faceted crystalline calcifications were observed by scanning electron microscopy (SEM). Some of the calcifications had compositions similar to that of hydroxyapatite; others contained a high concentration of aluminum.