Oprah Winfrey has revealed that she has no plans to run for president in 2020 because she believes the the current political landscape would 'kill' her.

The 64-year-old media mogul has graced the cover of British Vogue, and inside the pages of the magazine, she has opened up about whether she would ever consider making a run for commander in chief after becoming somewhat of a dream candidate for Democrats earlier this year.

'In that political structure — all the non-truths, the bulls**t, the crap, the nastiness, the backhanded backroom stuff that goes on — I feel like I could not exist,' she said. 'I would not be able to do it. It's not a clean business. It would kill me.'

Famous face: Oprah Winfrey graces the cover of British Vogue's August issue, in which she insists she will not run for president because the political landscape would 'kill' her

Not for her: The 64-year-old media icon, who looks like a queen in the regal spread, said she would not be able to 'exist' in politics because it is 'not a clean business'

The media icon appears on the cover of the magazine's August issue, dressed in a white, off-the-shoulder, custom-made taffeta Stella McCartney gown.

Her hair is pulled back to reveal Buccellati earrings with white and yellow diamonds as well as emeralds, while the headline reads: 'Oprah's next act — an audience with a global powerhouse.'

Although perhaps the most candid interview she has given on the subject of her potential presidential campaign, it is not the first time Oprah has addressed the furious speculation that she would make a bid for the White House in 2020.

In February of this year, she told People that it would take a divine intervention from God to convince her to run - despite both her long-time partner Stedman Graham and her best friend Gayle King appearing to push her towards a campaign.

'I pay attention, and when you have that many people saying something, I thought gee, I never in my life, ever, ever, thought I would be in politics. I've always said no no no no no,' she said at the time. 'Am I at least supposed to look a that question?

'I had enough people, billionaires calling me, saying I can get you a billion dollars, I can run your campaign.

'And I went into prayer. God, if you think I’m supposed to run, you gotta tell me, and it has to be so clear that not even I can miss it.'

Her admission came just weeks after she was widely praised for the inspirational speech she gave at the 2018 Golden Globes, where she brought the crowd to tears with her passionate delivery.

Twitter users went wild over the barnstorming speech, joking that the former talk show host should make a run in 2020 - with some even speculating that her emotional words at the award ceremony could be construed as her first campaign speech.

Shortly after she appeared on the stage at the awards, 'Oprah 2020' began trending on Twitter, with many viewing the success of the speech, during which she looked ahead to a time when no woman will have to utter the words 'me too' again, as a clear sign that the TV mogul is destined to lead the country.

After opening up to Vogue about how she reached her decision, Oprah also weighed in on feminism in the wake of the Times Up movement, noting that she has opted to focus on the positives that have come from it.

'People talk about "these are such dark times," but what if we shift the paradigm? Because I see it differently,' she said. 'I see, "Isn't this remarkable that we're waking up?"

Cover: Oprah is dressed in a white, off-the-shoulder, custom-made taffeta gown by Stella McCartney on the magazine's cover

Iconic: The mogul (pictured with U.S. Vogue editor-in-chief Anna Wintour) appeared on the cover of U.S. Vogue's October 1998 issue

'For years, women have endured craziness,' she added. 'This is what's happening to people. They're allowing themselves to not just become corroded, but to become hysterical. You've got to lean to the happiness.'

The former talk-show host also spoke about losing her son after giving birth at the age of 14.

Oprah has been open about the sexual abuse she suffered as a young girl, which resulted in her pregnancy.

Her son died in the hospital a few weeks after she gave birth, but she said she has moved on from the traumatic experience and chooses not to think about it.

'I actually saw someone the other day and they said how old they were — 45 — and I was thinking, well, how old would my son have been? I'm 64 — so he would have been 50. But I don't think about it.

'Considering the fact I've interviewed so many people who were haunted by [the death of a child], and who got stuck and never moved on, yes, I feel very liberated by it.''

The cover comes a little over than a month after Oprah, whose shows have aired in the UK, attended Prince Harry and Meghan Markle's wedding at Windsor Castle, making her one of a few Hollywood A-listers to appear at the royal occasion.

Oprah thanked Edward Enninful, 46, who became British Vogue's editor-in-chief in April last year, for featuring her on the publication's cover.

'This was an incredibly regal experience. Thank you @edward_enninful and @britishvogue for making me Empress for a day,' she wrote on Instagram.

Thanks: The media icon took to Instagram on Monday to thank editor-in-chief Edward Enninful for featuring her on the publication's cover

Oprah also praised photographers Mert Alas and Marcus Piggott, who snapped the cover shot, adding: 'And @mertalas, @macpiggott... a dream I didn't even know I had to be photographed by you two.'

The mogul appeared on the cover of U.S. Vogue's October 1998 issue, then aged 44 years old.

She posed in a strapless black gown as a headline announced: 'Oprah! A major movie, an amazing makeover.'

Boss: Edward, 46, became British Vogue's editor-in-chief in April last year

October 1998 marked the release of Beloved, a movie based on Toni Morrison's novel of the same name, which Oprah produced and starred in.

Prior to the release of her British Vogue cover, Oprah opened up about her experience at the royal wedding, writing about the deeper meaning behind Harry and Meghan's union in the August issue of O, The Oprah Magazine, which hits newsstands on July 10.

'What the Harry and Meghan moment symbolized for me are the possibilities that await us all when we choose love—in any form,' Oprah wrote in her 'What I Know For Sure' column.

Oprah said she had the same takeaway when she listened to the Most Reverend Michael Curry’s sermon about the power of love at the ceremony, noting that you couldn't watch the Harry and Meghan's nuptials without feeling it.

'It gave us hope, that wedding. Hope that we can all do what Mara Gay described in her New York Times opinion piece as "imagining the day when we wake up and remember who we want to be,"' she explained.

Looking back: Oprah opened up about attending Prince Harry and Meghan Markle's royal wedding on May 19, saying the nuptials 'gave us hope'

The wedding guest: The 64-year-old wrote about the experience in her latest 'What I Know For Sure' column featured in the August issue of O, The Oprah Magazine

'We all want to feel as radiant, joyful, and alive as Meghan looked on her way down the aisle to meet Harry. Both of them were glowing with happiness,' she added.

'I can’t wait to see the goodness that will come from their union. Goodness that I know for sure will help change the way the world thinks about what is possible, even more than it already has.'

Although Oprah is one of the most famous women in the world, she, too, was blown away when she stepped onto the grounds of Windsor Castle, and she admitted she was 'unprepared for the depth of emotion' she felt in that moment.

'It literally took my breath away,' she recalled. 'I exclaimed out loud to no one in particular: "Whoa! This right here is a whole 'nother level!"'

The iconic talk-show host looked stunning in a pink Stella McCartney frock for the wedding, but there was a bit of drama over her dress the night before.

After she realized the cream dress she was supposed to wear looked 'more white' in the daylight, the designer's team created her a rose-colored variation to keep her from committing a fashion faux pas.

On the day of the royal wedding, Oprah took to Instagram to share a video of herself in the pink dress, while showing her gratitude for the designer and her team.

'Thank you @stellamccartney!' she wrote. 'Realized Friday morning the beige dress I was planning to wear to Royal ceremony would photograph too "white" for a wedding. Her team did this overnite.'

Power of love: 'What the Harry and Meghan moment symbolized for me are the possibilities that await us all when we choose love—in any form,' Oprah said

Unforgettable: The former talk-show host recalled the 'depth of emotion' she felt when stepping onto the grounds at Windsor Castle (pictured)

In the playful clip, she adds: 'We had dress-gate! Wrong color! Now we got the right color! I think we're going to do OK.'

Last month, Oprah shared details about her April 28 meeting with Meghan's mother, Doria Ragland, which took place just three weeks before the royal wedding at the TV mogul's lavish California home.

Speaking to ET at the premiere of her new TV series Love Is in Los Angeles, she revealed that she and Doria, 61, spent the afternoon together at her $88 million 'Promised Land' mansion in Santa Barbara bonding, doing yoga, and eating kumquats from her garden.

Doria was seen leaving Oprah's house after a six-hour visit carrying a selection of gifts, including a basket containing some of the broadcasting legend's favorite things.

However, Oprah fired back at suggestions that the gifts had anything to do with her trying to convince Doria to do an interview in the wake of her daughter Meghan's marriage to Prince Harry.

'The story was that Meghan's mom had come to my house and she left laden with gifts,' Winfrey shared.

'You know what the gifts were? First of all, she's great at yoga, so I said, "Bring your yoga mat and your sneaks in case we just want to do yoga on the lawn." So one of the bags was a yoga mat and the other was lunch.'

Oprah also shared that the pair ate together and snacked on a dessert made from kumquats freshly picked from Oprah's garden.

'She said, "I love kumquats," and I said, "I have a kumquat tree!"' Oprah detailed.

See the full feature in the August issue of British Vogue, available on digital download or on newsstands Friday July 6