Mike and the Mad Dog are once again on bad terms.

Chris “Mad Dog” Russo revealed this week on the Sports Illustrated Media Podcast that there’s a rift between him and Mike Francesa after the two had patched things up to the point where they did a big reunion show three years ago at Radio City.

Russo had previously said he was surprised that his longtime radio partner returned to WFAN after leaving for a brief retirement, and Russo also appeared on the rival “Michael Kay Show” on the final day of the winter book during Kay’s ratings war with Francesa.

“I think that caused a little rupture,” Russo said. “I kind of, maybe I hinted that I wouldn’t have done that. So I questioned it — lightly, but I questioned it — and I think that caused probably a little disharmony between the two of us. We haven’t spoken in a year, year and a half.”

Francesa was in the news Tuesday as he announced his subscription app was purchased by Radio.com, killing the much-ballyhooed service after about a year, with the contents now free on Radio’s app.

Russo told The Post in May that the famous WFAN duo hadn’t spoken since Francesa returned to the airwaves. The two famously split in August 2008 after nearly two decades because their relationship soured.

“We’ll speak again,” Russo said on the podcast. “I could cure cancer, nothing is gonna top — at least in New York — the ‘Mike and the Mad Dog’ 19-year run. We will speak again, but we have had an issue.”