Police say they are making serious progress in the war against one of the country's biggest outlaw motorcycle gangs, the Rebels.

A targetted police crackdown and pressure from anti-bikie laws mean that for the first time ever the club has not held its annual national run - normally a display of the gang's size and strength.

New South Wales police said they had little sympathy for the Rebels, with gangs squad commander Detective Superintendent Deborah Wallace labelling the group a danger to the community.

"Outlaw motorcycle gangs aren't just harmless motorcycle clubs," she said.

"They're well-organised criminal gangs, and they cause harm right across the country. So they need to be targetted for their criminal activities."

Between February 2012 and September this year approximately 3,000 people were arrested by the Australian Crime Commission's Attero National Task Force, set up to crackdown on the Rebels.

It laid more than 4,200 charges including serious assault, stalking, kidnapping and affray as well as a range of firearms and weapons offences, drug offences, property, street and traffic offences.

A new national anti-bikie gang taskforce called Operation Morpheus has been operating since September, and includes officers from all state and territory police agencies as well as the Australian Crime Commission, the AFP and other bodies.

Strike Force Raptor disrupting Rebels 'on all levels'

In November alone, more than a dozen Rebels members have been charged in NSW with serious offences including extortion, kidnapping and assault.

Detective Superintendant Deborah Wallace said police were also disrupting the Rebels by targeting them for tax evasion and the illegal sale of alcohol.

"Our officers do a whole range and at times they do long-term investigations and one of the strongest arms of our squad is Strike Force Raptor," she said.

Rebels motorcycle gang boss Alex Vella remains stranded in Malta after the government cancelled his visa. ( AAP: Dean Lewins )

"They're our proactive arm and they are the ones that you'll see going through the clubhouses, going through the street every day. And their idea is to disrupt them on all levels."

Adding to the Rebels' woes in 2014, their national president Alex Vella has been stranded overseas since the Government cancelled his visa on character grounds while he was on holiday in Malta in June.

Then in October the High Court upheld revamped anti-consorting laws in NSW which make it an offence for convicted criminals to repeatedly associate with each other.

Detective Superintendant Wallace said all the pressure was having an impact on the Rebels.

'I think we've had a significant impact ... this year they didn't have their national run which is the first time ever," she said.

"I think they're feeling quite vulnerable at the moment, which doesn't mean we relax our strategies or relax our approach, it means we keep going."

The Rebels were contacted for comment on this story, but declined on the advice of their lawyers.

There is no word yet on whether the club plans to hold a national run in 2015.