Shulk The hero of the story, Shulk wields the Monado in battle, which gives him the unique ability to see visions of the future. He now seeks to destroy the dreaded Mechon who wiped out his home.

Fiora Shulk's childhood friend and the younger sister of Dunban, Fiora, is a cheerful, energetic, and caring young girl. She gets along quite well with Shulk, and often cooks for him!

Sharla Sharla is a combat medic with a strong, courageous heart, who cares for her brother, Juju. She joins Shulk to find the fiancé she once fought alongside. She uses her long-range ether rifle to both heal and attack.

Dunban Fiora's older brother, Dunban, is known as a hero who saved Bionis with the Monado. He's no longer able to use his right arm due to the excessive power of the Monado, but wields a katana in combat with just his left arm.

Reyn A tough, hot-headed fighter, Reyn is a childhood friend of Shulk and Fiorna and is now a member of the Colony 9 Defence Force. .

Riki Riki is a small forest creature called a Nopon, His playful personality makes him seem very young, but he's actually a father with eleven children. Known as the chosen Heropon, Riki joins Shulk’s quest to destroy the Mechon.

Melia Melia is a High Entia girl who lives in the Imperial Capital of Alcamoth on the head of Bionis. She acts with a refined and serious demeanor, and becomes a trusted ally to Shulk. Her attacks with the Ether Arts are extremely powerful.