New York City transportation authorities have inflicted lots of bike lanes on locations where they are particularly inappropriate. But for sneering, arrogant disregard — make that contempt — for the surroundings, none can equal the plan for a “protected” bike lane along Midtown’s Sixth Avenue from West 35th Street to Central Park South this year.

The latest stroke by Mayor Bill de Blasio’s Department of Transportation is part of a wider strategy to add 10 more miles of “protected” lanes in the city, which will also descend upon 10 blocks of Fifth Avenue in Harlem, among other corridors.

But the Sixth Avenue lane raises the bar for malicious streetscape tampering. A bike lane right on the doorsteps of Manhattan’s most vital office towers seems willfully spiteful — a thumb in the eye of profit-making capitalism with a slap at the avenue’s burgeoning hospitality and cultural resources.

Remember: The number of people in the Big Apple who bike to work is a minuscule 86,000, and that’s according to cycling’s staunchest advocates. The number who go to work by other means is 3.6 million, according to the US Census. Comparative data for recreational uses would show commensurate disparity.

So for the sake of a mere few who will bike to work on Sixth Avenue, the city is going to ruin the dynamism and vitality of Manhattan’s most successful office corridor — with unpredictable results.

The blocks along the planned bike lane boast the borough’s lowest office availability — 9.5 percent. Companies along the route include Bank of China, Bank of America, UBS, Mizuho Americas, News Corp. (which owns this newspaper), Deloitte, Bessemer Trust, Comcast, Major League Baseball, H.I.G. Capital and law firm Blank Rome.

These firms and the landlords whose buildings they fill are potent drivers of Gotham’s economy. They employ tens of thousands of highly paid workers (and plenty of middle-class New Yorkers, too). The firms collectively fill the city coffers with real-estate and ­income-tax revenue.

But the bike lane will remove an entire lane of vehicular traffic and disrupt vital drop-offs, pickups and deliveries. The lane will eliminate at least one, but more likely two, of six traffic lanes. The DOT threatens a “mixture of lane ­removals, lane-width modifications and parking removals.”

The exhilarating visual drama of Sixth Avenue will be interrupted by cars parked in the middle of the street. At every corner where left-turn traffic lanes merge with the bike route, expect the usual confusion where neither drivers, cyclists nor pedestrians know who has the right of way.

Of course, “Big Six” today is much more diverse and people-friendly than it once was. The lane will also impede access to proliferating hotels and restaurants and to cultural and retail uses in which de Blasio has never shown interest. Among them: the Steinway & Sons Piano showroom, Radio City Music Hall, a soon-to-open MLB flagship store and the “Tonight Show” entrance.

With luck, Sixth Avenue will still be able to host the Macy’s Thanksgiving Day Parade, which was chased off Broadway by bike lanes and “pedestrian plazas” that proved impossible for floats and balloons to navigate. In the era of the all-powerful DOT, Garfield and Astronaut Snoopy proved no match for Citi Bikes.

But muffling the energy of Big Six with a bike route guarantees more stop-and-go traffic year-round. How could it not when auto lanes are eliminated, but not the numbers of vehicles that need to use them?

Cycling advocates as always will blame added “congestion” on Uber. They will say it proves that we need even more bike lanes. And thanks to their pandering elected enablers, they’ll get their wish — and damn the consequences for everyone else.

scuozzo@nypost.com