A lopsided Thursday night matchup against the Patriots means you should keep Daniel Jones, Darius Slayton, et al. out of your fantasy football lineups. Below are some good plays for Week 6, as well as some other guys you should consider avoiding.

Who to Start

— Matt Ryan, Atlanta Falcons at Arizona Cardinals (QB): Ryan had another huge fantasy game on Sunday against the Texans in which he attempted 46 passes and had 32 completions, 330 yards, four touchdowns and one interception. This hobbled Falcons defense is going to force the offense to score a lot of points in order to keep them competitive in any games, meaning Ryan will have to throw a lot. He has a great Week 6 matchup in Arizona and has the chance to finish as the number one quarterback.

— Terry McLaurin, Washington Redskins at Miami Dolphins (WR): McLaurin is back after missing Week 4 with a hamstring injury. He has been the lone bright spot on this abysmal team that just relieved head coach Jay Gruden of his duties. Up against a tough New England secondary, he caught three passes for 51 yards. His Week 6 matchup is much easier opposite a Dolphins team that is openly playing for the first overall pick of the draft. McLaurin is a WR2 with upside this week.

— Michael Gallup, Dallas Cowboys at New York Jets (WR): Gallup suffered a meniscus tear in Week 2 that required surgery, forcing him to miss two games. He returned in a difficult spot versus a Green Bay secondary that has played well this year and caught seven of 19 targets for 113 yards and a touchdown. The Jets secondary will be a much easier matchup for Gallup, who is the clear cut No. 2 receiver in Dallas. He is also a WR2 with upside in Week 6.

— Kerryon Johnson, Detroit Lions at Green Bay Packers (RB): Johnson is having a nice season so far and comes into this game well-rested off a Week 5 bye. He faces a Packers run defense that had looked subpar through four weeks. They were able to keep Ezekiel Elliott relatively quiet on Sunday, but that had more to do with the Cowboys abandoning the run and Dak Prescott having to attempt 44 passes. He is a RB2 with RB1 upside this week.

— Chris Carson, Seattle Seahawks at Cleveland Browns (RB): Carson looks to be on the upswing having strung together two 100-yard games without a fumble. Carson has a history of ball security issues that date back to his Oklahoma State days and he fumbled in each of the first three games of the season. The Browns will be on short rest having just allowed the 49ers running backs to score three touchdowns and combine for 280 yards. Carson is a solid RB1 this week.

— Austin Hooper, Atlanta Falcons at Arizona Cardinals (TE): The Cardinals struggles have been ubiquitous this season, but they have had a particularly hard time keeping tight ends at bay. They have allowed six touchdowns to tight ends this season, giving Hooper a great chance to make it into the end zone.

— Carolina Panthers D/ST at* Tampa Bay Buccaneers: After a slow start to the season, the Panthers defense has stepped up since quarterback Cam Newton has been out since Week 2. They have 20 sacks so far, second to only New England, which should keep a turnover-prone Jameis Winston on his toes (or on his back) the whole game.

Who to Sit

— Daniel Jones, New York Giants at New England Patriots (QB): It looks like Jones has a bright future and will have some great games for fantasy owners — this, however, will unlikely be one of them. He faces the top defense in the NFL that has allowed a mere 22 points this season and leads the league in sacks, interceptions, and touchdowns. Jones will be missing his top weapons, with Sterling Shepard and Wayne Gallman in the concussion protocol, Saquon Barkley unlikely to return this week, and Evan Engram banged up. Sit Jones at all costs, especially with decent quarterbacks on the waiver wire.

— Marquez Valdes-Scantling, Green Bay Packers vs. Detroit Lions (WR): Davante Adams is still “week-to-week” with a turf toe injury he suffered during Week 4 against the Eagles. Ordinarily, this would be good news for a No. 2 receiver. However, the Detroit secondary has been formidable this year, and if Valdes-Scantling ends up being the Packers’ No. 1 on Monday, he will draw coverage from star cornerback Darius Slay with Geronimo Allison in the slot. He is a low end WR3/flex this week.

— Darius Slayton, New York Giants at New England Patriots (WR): Slayton has a bad matchup for all the aforementioned reasons for Jones. Specifically, with Golden Tate in the slot, he will probably play outside draw coverage from cornerback Stephon Gillmore, who has been dominant all season. Slayton has appeal down the stretch in a thin Giants wide receiving corps, especially if the oft-injured Shepard misses more time, but he is a definitive sit this week in New England.

— Jordan Howard, Philadelphia Eagles at Minnesota Vikings (RB): A three-touchdown game against the Packers in Week 4 made Howard, now 85% owned, a popular waiver add. He scored again in the following week versus the Jets and accrued 62 yards on 13 rushes. These two performances seemed flukey, even while watching them. Howard’s only other three-score game came in his rookie year in Chicago, and his success throughout his career has been entirely dependent on workload as a low yards per carry player. Do not count on him for RB2 production this week against Minnesota, whose run defense has been solid this year.

— Royce Freeman, Denver Broncos vs. Tennessee Titans (RB): Bad news for fantasy owners: It appears to be a true running back committee in Denver with Phillip Lindsay getting the slightly better deal. Freeman has 55 rushes in comparison to 69 for Lindsay and has two fewer targets than his counterpart. He has yet to score this season, and will line up opposite a Titans defense that has allowed an average of 15.2 points per game to offenses this year. This is not a good matchup for either Broncos running back.

— O.J. Howard, Tampa Bay Buccaneers vs.* Carolina Panthers (TE): At 79% owned, it looks like the fantasy community is still clinging to hope that Howard can turn his season around. It has been a disappointing one to say the least, especially for owners who spent TE1 draft capital on him. The Panthers secondary has been sneaky good this year, and their pass rush will likely challenge quarterback Jameis Winston. You should not have to count on Howard this week with much better options on the waiver wire.

— Jacksonville Jaguars D/ST vs. New Orleans Saints: Everyone wrote the Saints off after quarterback Drew Brees went down with a hand injury, but backup Teddy Bridgewater has kept this team atop the NFC South. He proved he could be more than just a checkdown quarterback on Sunday and threw for 314 yards and four touchdowns. He is surrounded by offensive weapons that will present quite the challenge for this Jacksonville defense, which may be without disgruntled cornerback Jalen Ramsey once again. Sit the Jaguars this week and find a D/ST with a more favorable opponent.

* Set your alarms! Panthers at Buccaneers will be played in Tottenham, England at 9:30 a.m. EST.