Port Stephens police have uncovered a large hydroponic cannabis set up at a house in Limeburners Creek.

Detectives investigating the cultivation of cannabis in the Port Stephens region raided a house in Fords Road at Limeburners Creek on Tuesday.

They allegedly uncovered a sophisticated hydroponic cannabis operation, seizing 69 plants along with a kilogram of cannabis leaf.

A 63-year-old man was arrested and charged with cultivating and supplying an indictable quantity of cannabis, along with firearm offences.

He was granted conditional bail and will face Raymond Terrace Local Court in August.

Meanwhile, a 44-year-old Mayfield man is due in Newcastle Local Court today, charged with drug supply.

He was arrested after police searched his car in Hanbury Street on Tuesday, allegedly seizing cash and prohibited drugs.