A stand-up comedy charity event in Boston on Saturday turned ugly when Wanda Sykes responded to boos prompted by her criticism of Donald Trump with expletives and foul gestures.

Sykes was met with jeers from the thousands in attendance at Boston's TD Garden arena when she unloaded on the President-elect, theBoston Globe reported.

'I am certain this is not the first time we've elected a racist, sexist, homophobic president,' the comedian told the crowd. 'He's just the first confirmed one, that's it.'

Sykes also went on to call Trump 'an orangutan.'

The comments elicited boos from the audience, which prompted Sykes to go on the defensive and respond with a middle finger.

Comedian Wanda Sykes (above) appeared Saturday night at TD Garden arena in Boston for a charity event aimed at raising money for cancer research

When Sykes' anti-Trump remarks were met with jeers, she then began using profanity and flashed a middle finger (above) before angrily leaving the stage

She also told those in attendance jeering her to 'f*** off.'

'F*** you, motherf***er, f*** all of y'all,' she said.

Sykes was one of eight performers to appear at the annual Comics Come Home fundraiser, which is staged to benefit the Cam Neely Foundation for Cancer Care.

Sykes prefaced her comments by saying that she was fearful of a Trump presidency and its ramifications given that she was black and a lesbian.

Denis Leary, the Massachusetts-born comedian who has hosted the event since its inception, defended Sykes.

'For 22 years we have never censored any performer at Comics Come Home,' Leary said in a statement.

'Each comedian is free to speak their mind. This has resulted in the longest running stand up charity event in America.'

Sykes is known for her avowedly liberal views.

In 2009, she made headlines in the wake of her appearance at the annual White House Correspondents Association dinner, a Washington, D.C. event of movers and shakers attended by President Barack Obama.

Watch out-of-touch elitist comedian Wanda Sykes get booed by an arena for calling a #Trump racist/sexist, then tell the crowd to F itself. pic.twitter.com/ax7qUVdtNT — Tim Young (@TimRunsHisMouth) November 13, 2016

Last night, Wanda Sykes was booed off stage during #ComicsComeHome for an anti-Trump rant.



��: @SamDeGreen pic.twitter.com/rl5EH12XGs — Only In Boston (@OnlyInBOS) November 13, 2016

During her routine, she noted that conservative radio personality Rush Limbaugh had wished for Obama's failure as president.

In response, she said: 'I hope his [Limbaugh's] kidneys fail, how 'bout that? Needs a little waterboarding, that's what he needs.'

Sykes is known for her avowedly liberal views. During an appearance at the 2009 White House Correspondents dinner with President Barack Obama (right), she said she hoped conservative radio personality Rush Limbaugh would suffer from kidney failure

Sykes was not the only comic to raise eyebrows with her performance.