Hillary Clinton and Bernie Sanders are headed to Miami for the next Democratic presidential debate, and given some surprising primary results this week, the event has taken on new urgency.

The former secretary of state and the Vermont senator will debate for the second time in four days Wednesday at Miami Dade Community College. The showdown, set to start at 9:00 p.m. Eastern Time, will be hosted by Univision and the Washington Post and broadcast in both English and Spanish.

The event comes on the heels of what was a surprising evening in primary voting on the Democratic side. Clinton, who polls showed with a double-digit lead in the days heading into the Michigan primary, suffered a stunning defeat by Sanders in the Wolverine State. The senator narrowly defeated the former first lady with about 49.9% support compared to her 48.2%.

In an email to supporters, the Sanders camp called its Michigan win a "major, game-changing victory" for its campaign.

"What tonight means is that the Bernie Sanders campaign, the people's -- the revolution -- the people's revolution that we are talking about, the political revolution that we are talking about, is strong in every part of the country, and frankly, we believe that our strongest areas are yet to happen," Sanders said in a speech delivered at a rally in Miami Tuesday evening, emphasizing that he expects to do well in primary voting on the West Coast as well.

The night wasn't an all-around victory for Sanders, however. Clinton landed a sizable victory in Mississippi, which also held its Democratic and Republican primaries Tuesday, pulling in 82.6% of the vote compared to Sanders' 16.5%.

In an email to supporters of her campaign sent Tuesday, Clinton's team made a nod to Republican frontrunner Donald Trump, who notched primary wins in Michigan, Mississippi and Hawaii and came in second to Ted Cruz in Idaho (Hawaii and Idaho will hold Democratic primary voting later this month).

"The forces trying to drive us apart are strong. But I believe our campaign and our country should be about breaking barriers and building on what made America great in the first place," the email reads. "America's diversity is a strength, not a weakness. Trying to divide this country between 'us' and 'them' is simply wrong. Our mission is to do as much good as we can for the most people we can -- we have to open our hearts to helping others."

Tuesday's primary surprise in Michigan doesn't doom Clinton's campaign, but it does demonstrate that all is not said and done in the Democratic race.

In a separate email sent Wednesday morning, camp Hillary had a more somber tone, albeit not defeated. "We've all known that this primary isn't over, and last night's results reminded us we still need to fight for every last state and delegate," the email reads.

Wednesday's debate will give Clinton a chance to continue her fight for the nomination against Sanders, who at Sunday's presidential debate in Flint, Mich. showed more bite than he has in showdowns past.

He hit her on his usual talking points -- her super PAC, Wall Street ties and speeches at Goldman Sachs -- and made a strong attack on her previous support of free trade and agreements like NAFTA. After Clinton discussed her "carrots and sticks" approach to keeping jobs in the United States, Sanders retorted: "I am very glad ... that Secretary Clinton discovered religion on this issue, but it's a little bit too late. Secretary Clinton supported virtually every one of the disastrous trade agreements written by corporate America."

The former New York senator came with her own ammo on Sanders, calling him out for voting against the auto bailout in 2009. "If everybody had voted the way he did, I believe the auto industry would have collapsed, taking four million jobs with it," she said.

At tonight's debate, both Clinton and Sanders will be looking ahead to primary voting in states like Florida, Illinois, Missouri, North Carolina and Ohio next week. According to RealClearPolitics averages, Clinton holds a comfortable lead nationally and state-by-state, but given yesterday's Michigan shocker, it could still be anybody's game.