Spoilers Ahead!

The protagonist is the child of a family broken by nuclear disaster, a nuclear physicist mother lost in the unexplained explosion of a power plant, and a workaholic father distanced by his resulting grief. The antagonist of Uranium is actually a Pokémon, Urayne, and its mysterious masked partner known as Curie. As Curie and Urayne begin sabotaging nuclear plants throughout the region, the fallout from the meltdowns causes the evacuation of Vinoville, the most rural city of the region, and contaminates wild Pokémon, causing them to attack people in rabid hordes. The game's message is not so simplistic as to outright condemn nuclear energy as being too risky, (though a citizen or two of Vinoville says exactly that), but the need for caution and accountability is abundantly clear. It is revealed that Urayne was created as an organic reactor core, a laboratory-engineered Godzilla, threatened with extinction as soon as it achieved the undesirable outcome of consciousness. Urayne's rampage is merely the result of fearful self-preservation and its unsustainable subsistence on pure uranium fuel. Its tragic insatiable hunger is the embodiment of the arrogance that led to its creation.

It is historically ironic, or perhaps appropriate, that this is an unlicensed American-made game using Japanese intellectual property to make a statement about nuclear power. Japan is still the only nation to have experienced the horror of nuclear weapons with the U.S. bombings of Hiroshima and Nagasaki in 1945. The fear of nuclear destruction still looms large in the nation's collective consciousness, but that hasn't stopped Japan from investing heavily in nuclear energy. In fact, Japan's nuclear industry was relatively un-phased by the implications of the Three Mile-Island crisis (1979) in the U.S. and the Chernobyl disaster (1986) in Soviet Ukraine. While there was no shortage of opposition from Japanese citizens similar to that of environmentalists in the U.S., a combination of economics and politics made their protest less effective on the continued government approval of proposals for new plants. It may seem hypocritical to suggest that Pokémon Uranium's message applies particularly well to Japan, considering that the U.S. is the world's largest supplier of commercial nuclear power and that U.S. companies sold Japan its first light water reactors. However, what makes nuclear power in Japan especially troubling is the questionable resilience of such volatile reactors on a seismically active island riddled with fault lines.

On March 11th, 2011, the most powerful earthquake known to ever hit Japan caused a tsunami that crippled the Fukushima Daiichi nuclear plant, disabling its cooling systems and resulting in meltdowns and explosions. The fallout caused over 100,000 people to be evacuated from their homes, most of whom still cannot return. The catastrophe re-ignited the anti-nuclear movement worldwide. In Japan the disaster confirmed the public's long-held skepticism of government safety standards. In 2012 The Chairman of the Japanese Nuclear Safety Commission admitted the organization had "…succumbed to a blind belief in the country’s technical prowess and failed to thoroughly assess the risks of building nuclear reactors in an earthquake-prone country".