In the online game EteRNA, players are helping to create the first large-scale library of synthetic RNA designs. You don’t need to be a biology major to help reveal new principles for designing RNA-based switches and nanomachines — new systems for seeking, and eventually controlling, living cells and disease-causing viruses. By interacting with thousands of players and learning from experimental feedback, players are pioneering a new way to do science.Each colored sphere represents one of four types of nucleic acids: adenine (yellow), uracil (blue), guanine (red) and cytosine (green). Clicking the RNA mutates nucleic acids and refolds the RNA into its most stable shape. EteRNA challenges players to design RNAs which fold properly in practice. Visit EteRNA to play the full version.