Liked your comic. I understood the majority of it without the explanation.



1 . Seems to be taking place in an alternate setting. More collegiate, less feudal. True to character, Twilight finds the concept of making friends abhorrent, so she tries to science/magic her way out of it. The exact nature of Celestia isn't currently important to the story, and, much like the show, should be left to the reader's imagination. (At least until such time as it does become important.)

2,4 . In stories, potions aren't generally known for being active while they're just sitting there (they usually need to be drunken or otherwise 'excited'), so I naturally assumed the fanon Pinkie fourth wall abilities. This may not even be the Pinkie from her universe.

3 . Couldn't remember what QED meant (though recognized it as a message closer). Considering it was alongside another image of Pinkie winking to the audience, its exact meaning didn't seem important. If someone cares enough, they could just google it.

5 . Spotted all the zodiac symbols, but didn't attach specific importance to them since I wasn't aware of the Philosopher's Stone connection. (Actually, for a minute it made me think this might be a Final Fantasy Tactics crossover.) Considering there's no plot reference made to them, it really shouldn't need to be explained right now. Merely serves as an extra bonus to smart people.



What I'm saying here is that I think you're doing a fine job. And unless I've completely missed the point above, I do not think you have made any serious mistakes.



Still, know your audience. If I'm the only one who got remotely close (or not, as the case may be), then maybe some simplification is in order.