Freedom of information laws are being misused to harass scientists and should be re-examined by the government, according to the president of the Royal Society.

Nobel laureate Sir Paul Nurse told the Guardian that some climate scientists were being targeted by organised campaigns of requests for data and other research materials, aimed at intimidating them and slowing down research. He said the behaviour was turning freedom of information laws into a way to intimidate some scientists.

Nurse's comments follow the launch of a major Royal Society study into how scientists' work can be made more open and better used to inform policy in society. The review – expected to be published next year – will examine ways of improving access to scientific data and research papers and how "digital media offer a powerful means for the public to interrogate, question and re-analyse scientific priorities, evidence and conclusions".

Nurse said that, in principle, scientific information should be made available as widely as possible as a matter of course, a practice common in biological research where gene sequences are routinely published in public databases. But he said freedom of information had "opened a Pandora's box. It's released something that we hadn't imagined ... there have been cases of it being misused in the climate change debate to intimidate scientists.

"I have been told of some researchers who are getting lots of requests for, among other things, all drafts of scientific papers prior to their publication in journals, with annotations, explaining why changes were made between successive versions. If it is true, it will consume a huge amount of time. And it's intimidating."

It was possible some requests were designed simply to stop scientists working rather than as a legitimate attempt to get research data, said Nurse. "It is essential that scientists are as open and transparent as possible and, where they are not, they should be held to account. But at times this appears to be being used as a tool to stop scientists doing their work. That's going to turn us into glue. We are just not going to be able to operate efficiently."

Nurse said the government should examine the issue, and think about tweaking freedom of information legislation to recognise potential misuse. Otherwise, he predicted, FoI aggression could be in future used by campaigners to cripple scientific research in many other controversial areas of science, such as genetically modified crops. "I don't actually know the answer but I think we have a problem here. We need better guidelines about when the use of freedom of information is useful."

Bob Ward of the Grantham Research Institute at the London School of Economics said the intention of many of those making freedom of information requests was to trawl through scientists' work with the intention of trying to find problems and errors. "It's also quite true that these people do not care about the fact that it is causing a serious inconvenience," he said. "It is being used in an aggressive and organised way. When freedom of information legislation was first contemplated, it was not being considered that universities would be landed with this additional burden."

Evidence of the aggression first began to emerge when personal emails and documents were stolen from the University of East Anglia's (UEA) servers in November 2009 and leaked on to the internet. Climate sceptics seized on the contents as evidence that apparently showed scientists were colluding to keep errors in their research hidden and prevent rivals' research from being published at all.

In an independent inquiry a year later, the scientists at the UEA's climatic research unit (CRU) were cleared of any misconduct, but Muir Russell, the former civil servant who led the investigation, found a "consistent pattern of failing to display the proper degree of openness", although he stressed he had no reason to doubt the CRU team's honesty or integrity.

"The current fog of ambiguity concerning, for example, drafts of research papers produced in other countries is deeply damaging to our scientific standing," said Tom Ward, pro vice-chancellor at UEA. "Part of the discussion should be informed by what we can learn from Scottish and US law, which explicitly recognise the need to extend some protection to research in progress."

Myles Allen, a climate scientist at the University of Oxford, said he has been involved in many long-running exchanges with people making freedom of information requests for his data. "In the case that went on the longest, I answered all the guy's questions. I spent half a day writing a long email explaining the answers to all his questions, but it wasn't really that which he was after: he was after some procedural questions about IPCC [Intergovernmental Panel on Climate Change]. He wanted some evidence that an IPCC statement had been changed – it wasn't about science at all; it was about procedure."

He added: "I can see what someone with a very specific political comment might gain from an unguarded comment, but it's very hard to see how science or public understanding of science gains from every exchange between scientists being made public. No other discipline operates in that way. The net effect of this, incidentally, is that senior people in government and senior scientists close to government are basically just using the telephone again. Which is very bad for science because email exchanges are an extremely useful record."

Nurse said that scientists were not blameless. At the University of East Anglia, they were too defensive in their responses to freedom of information requests over climate change, but their experience was one among many that highlighted a need for better training for scientists in the most appropriate way to respond to information requests.

Ward agreed that most universities do not have a very good grasp of the requirements of freedom of information law. But he added that researchers should be able to have confidential conversations with colleagues and researchers in other universities, and that it was increasingly difficult for researchers to do that by email.

"There's no other walk of life where every conversation you have ought to be made public," he said. "There's a massive double standards because a lot of the people submitting these requests are themselves not transparent at all. They don't reveal their sources of funding or the details of what they're doing behind the scenes."

He added that the best way for scientists to respond was with more openness. "Scientists are going to have to get used to the idea that transparency means being transparent to your critics as well as your allies. You cannot pick and choose to whom you are transparent," he said. "Increasingly it is going to be an issue for anyone working in contentious areas. Part of retaining the public's confidence and trust is transparency and openness, and scientists should accept that that is part of the price of having the people's trust."