A nurse has been fired after horrific footage emerged of him allegedly abusing a patient who suffers from a disability at a Melbourne hospital.

The footage was taken at Caulfield Hospital and was filmed by the family of the patient using a hidden camera inside a picture frame, The Herald Sun reports.

In the video, obtained exclusively by the newspaper, the nurse appears to grab patient Billy Aivaliotis by the throat before aggressively moving him around the room.

The nurse appears to grab Mr Aivaliotis' throat. (Herald Sun)

Mr Aivaliotis hospitalised after being struck by a car last year. (Herald Sun)

A hospital spokesperson told 9news.com.au the male staff member has been stood down and no longer works for Alfred Health.

"The video material presented to us by the family is distressing and shocking – and not in keeping with the culture of advanced care patients and families should experience in our hospitals," Alfred Health said in a statement.

"We are continuing to meet with the patient’s family and thank them for bringing these issues to our attention.

"Alfred Health is cooperating fully with the police investigation."

Police told 9NEWS they spoke with a 30-year-old Cranbourne West man but he was released pending further enquiries. (Herald Sun)

Billy Aivaliotis. (Herald Sun)

The 33-year-old, who was born with cerebral palsy, was hospitalised early last year after suffering a serious brain injury when he was struck by a car.

After being treated in the Royal Melbourne Hospital, he was eventually taken the Caulfield Hospital for further treatment.

His family told the newspaper they became concerned about Mr Aivaliotis after he began losing weight and showed signs of bruising.

The family has hired lawyers to defend Mr Aivaliotis. (Herald Sun)

The family said they were unhappy with the response when they approached the hospital and alleged they were “totally ignored.”

"Billy fought for his life after the accident. To beat death and recover, only to be abused and mistreated when completely defenceless, is ­totally devastating and infuriating," the family said.

"After this devastating realisation of mistreatment and abuse, we have absolutely no faith in this broken and failed system of care.

"Billy cannot voice his feelings. He is incapable of demonstrating his fears and concerns. His family is his voice, and we will do everything possible to ensure his safety and wellbeing.”

The family has hired lawyers to defend Mr Aivaliotis.

Caulfield Hospital. (File)

Victoria Police told 9news.com.au they are investigating allegations of assault of a patient at Caulfield Hospital on January 22.