On Wednesday night’s show, Mr. Watters announced he would be taking a vacation, missing the next two nights of “The Five,” as well as his weekend show, “Watters’ World,” on Saturday.

“I’m going to be taking a vacation with my family, so I’m not going to be here tomorrow and Friday,” he said. “But I’ll be back on Monday, so try not to miss me too much.”

The episode comes at a bad time for Fox News, the cable news giant that has been reeling from claims of sexual misconduct throughout the organization.

Mr. O’Reilly, one of Fox’s biggest stars, was forced out last week after the revelation that the network and Mr. O’Reilly had spent $13 million on settlements with five women who accused him of sexual harassment or inappropriate behavior.

Its former chairman, Roger Ailes, was ousted last year two weeks after several women, including Gretchen Carlson, a former anchor, accused him of sexual harassment.

This month, two more women accused Mr. Ailes of harassment: Julie Roginsky, a current contributor, asserted that she faced retaliation for rebuffing Mr. Ailes’ sexual advances, and Alisyn Camerota, a former anchor, accused him of saying “grossly inappropriate” things to her when she asked for new opportunities at work.