Vladimir Putin has said he hopes nuclear warheads will not be needed to deal with terrorists or anyone else, after Russia launched cruise missiles from its submarine at Syria.

During a meeting in the Kremlin, Russia’s Defence Minister Sergei Shoigu told the President that Kalibr cruise missiles had been fired by the submerged Rostov-on-Don submarine from the Mediterranean Sea for the first time.

He said TU-22 bombers also took part in the latest raids and that "significant damage" had been done to a munitions depot, a factory manufacturing mortar rounds and oil facilities. Two major targets in Raqqa, the defacto capital of Isis, had been hit, said Mr Shoigu.

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President Putin said the new cruise missiles could also be equipped with nuclear warheads - but that he hoped they would never need them.

He said: "With regard to strikes from a submarine. We certainly need to analyse everything that is happening on the battlefield, how the weapons work. Both the [Kalibr] missiles and the Kh-101 rockets are generally showing very good results. We now see that these are new, modern and highly effective high-precision weapons that can be equipped either with conventional or special nuclear warheads."

In pictures: Russian air strikes in Syria Show all 19 1 /19 In pictures: Russian air strikes in Syria In pictures: Russian air strikes in Syria Syrian boys cry following Russian air strikes on the rebel-held Fardous neighbourhood of the northern embattled Syrian city of Aleppo Getty In pictures: Russian air strikes in Syria Russian defense ministry spokesman Major General Igor Konashenkov speaks to the media in Moscow, Russia. Konashenkov strongly warned the United States against striking Syrian government forces and issued a thinly-veiled threat to use Russian air defense assets to protect them AP In pictures: Russian air strikes in Syria Syrians wait to receive treatment at a hospital following Russian air strikes on the rebel-held Fardous neighbourhood of the northern embattled Syrian city of Alepp Getty In pictures: Russian air strikes in Syria Russian Deputy Defense Minister Anatoly Antonov speaks at a briefing in the Defense Ministry in Moscow, Russia. Antonov said the Russian air strikes in Syria have killed about 35,000 militants, including about 2,700 residents of Russia AP In pictures: Russian air strikes in Syria Jameel Mustafa Habboush, receives oxygen from civil defence volunteers, known as the white helmets, as they rescue him from under the rubble of a building following Russian air strikes on the rebel-held Fardous neighbourhood of the northern embattled Syrian city of Aleppo Getty In pictures: Russian air strikes in Syria Civil defence members rest amidst rubble in a site hit by what activists said were airstrikes carried out by the Russian air force in the town of Douma, eastern Ghouta in Damascus, Syria Reuters In pictures: Russian air strikes in Syria A girl carrying a baby inspects damage in a site hit by what activists said were airstrikes carried out by the Russian air force in the town of Douma, eastern Ghouta in Damascus, Syria Reuters In pictures: Russian air strikes in Syria Civilians and civil defence members look for survivors at a site damaged after Russian air strikes on the Syrian rebel-held city of Idlib, Syria Reuters In pictures: Russian air strikes in Syria Civilians and civil defence members carry an injured woman on a stretcher at a site damaged after Russian air strikes on the Syrian rebel-held city of Idlib, Syria Reuters In pictures: Russian air strikes in Syria Volunteers from Syria Civil Defence, also known as the White Helmets, help civilians after Russia carried out its first airstrikes in Syria In pictures: Russian air strikes in Syria The aftermath of Russian airstrike in Talbiseh, Syria In pictures: Russian air strikes in Syria Smoke billows from buildings in Talbiseh, in Homs province, western Syria, after airstrikes by Russian warplanes AP In pictures: Russian air strikes in Syria Russian Air Forces carry out an air strike in the ISIS controlled Al-Raqqah Governorate. Russia's KAB-500s bombs completely destroy the Liwa al-Haqq command unit In pictures: Russian air strikes in Syria Caspian Flotilla of the Russian Navy firing Kalibr cruise missiles against remote Isis targets in Syria Â© TASS/ITAR-TASS Photo/Corbis In pictures: Russian air strikes in Syria Russia claimed it hit eight Isis targets, including a "terrorist HQ and co-ordination centre" that was completely destroyed In pictures: Russian air strikes in Syria A video grab taken from the footage made available on the Russian Defence Ministry's official website, purporting to show an airstrike in Syria In pictures: Russian air strikes in Syria A release from the Russian defence ministry purportedly showing targets in Syria being hit In pictures: Russian air strikes in Syria Russia launched air strikes in war-torn Syria, its first military engagement outside the former Soviet Union since the occupation of Afghanistan in 1979. Russian warplanes carried out strikes in three Syrian provinces along with regime aircraft as Putin seeks to steal US President Barack Obama's thunder by pushing a rival plan to defeat Isis militants in Syria In pictures: Russian air strikes in Syria Caspian Flotilla of the Russian Navy firing Kalibr cruise missiles against remote Isis targets in Syria, a thousand kilometres away. The targets include ammunition factories, ammunition and fuel depots, command centres, and training camps Â© TASS/ITAR-TASS Photo/Corbis

"Naturally, we do not need that in fighting terrorists, and I hope we will never need it. But overall, this speaks to our significant progress in terms of improving weaponry and equipment being supplied to the Russian army and navy."

Mr Shoigu said Israel and the US had been informed before the strikes were launched.

Russia's air campaign has been taking place since 30 September.

Russian Foreign Minister Sergey Lavrov later sought to temper any suggestion the country would use nuclear weapons on terrorists.

"Of course not, and the president has stated this, that there is no need to use any nuclear weapons against terrorists, as they can be defeated through conventional means, and this is fully in line with our military doctrine," he said.