Sen. Jeff Flake Jeffrey (Jeff) Lane FlakeJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Republican former Michigan governor says he's voting for Biden Maybe they just don't like cowboys: The president is successful, some just don't like his style MORE (R-Ariz.) took aim at President Trump Donald John TrumpOmar fires back at Trump over rally remarks: 'This is my country' Pelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Trump mocks Biden appearance, mask use ahead of first debate MORE on Wednesday, saying the president has "debased" the office with his "bottomless appetite for destruction and degradation."

“Our presidency has been debased by a figure who has a seemingly bottomless appetite for destruction and division, and only a passing familiarity with how the Constitution works" Flake said in a commencement address to Harvard Law School graduates, according to prewritten remarks.

“Our Article I branch of government, the Congress (that's me), is utterly supine in the face of the moral vandalism that flows from the White House daily,” Flake continued.

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The Republican senator went on to say that the country's strongest enemies could not hurt the U.S. more than "we are hurting ourselves," concluding that "we may have hit bottom."

Flake also criticized Trump for his continuing attacks on the media and what he views to be the president’s willingness to indulge and encourage “our very worst impulses.”

“When a figure in power reflexively calls any press that does not suit him ‘fake news,’ it is that person who should be the figure of suspicion, not the press,” Flake said.

Flake said his criticism of the president makes him no less Republican; instead, he called it an act of patriotic loyalty. The senator, who has gone after Trump in a number of recent speeches, has voted in line with Trump 84 percent of the time, according to FiveThirtyEight — one of the lowest percentages for Senate Republicans.

“My sounding this alarm against the government that was elected, under the Republican banner, and that calls itself conservative, makes me no less Republican or conservative,” Flake said. “And opposing the president and much of what he stands for is not an act of apostasy. It is, rather, an act of fidelity.”

Flake announced last year that he would retire in January after finishing one term in the Senate.