A fast-moving storm packing a litany of hazards — tornadoes, floods, severe storms and more — raged through the southern United States on Saturday, leaving at least 10 people dead and a trail of destruction in its wake.

The deaths included an elderly couple in northwest Louisiana who were killed when a tornado tossed their trailer home hundreds of feet and damaged more than 50 homes.

The deadly tornado was just one of a series of dangerous weather events tangled up in the storm system. Powerful winds pummeled Georgia and Tennessee, officials issued flood warnings in Mississippi and strong gusts were predicted in the Midwest. Warnings of hail and snow followed closely behind, extending from Oklahoma up through Michigan.

“This is one of the stronger systems that we’ve seen in recent years,” said Kurt Van Speybroeck, an emergency response specialist at the Southern Region Headquarters of the National Weather Service. On Saturday afternoon, the strongest part of the storm was moving over Alabama and Tennessee and headed east toward Georgia at about 40 miles per hour. It will likely roll over the Carolinas on Sunday and be off the coast by Sunday afternoon at the latest, Mr. Speybroeck said.