Australia's most infamous serial killer Ivan Milat has been transported handcuffed and under corrective services guard to Long Bay Prison Hospital in Sydney's south.

Key points: Ivan Milat received treatment in the high-security ward at the Princes of Wales Hospital for two weeks

Ivan Milat received treatment in the high-security ward at the Princes of Wales Hospital for two weeks The 74-year-old was convicted of killing seven backpackers and burying their bodies in NSW's Belanglo State Forest

The 74-year-old was convicted of killing seven backpackers and burying their bodies in NSW's Belanglo State Forest The Corrections Commissioner said he hoped Milat would speak to police about other crimes before he dies

Looking frail and dressed in prison greens, the 74-year-old was pushed in a wheelchair from the Prince of Wales Hospital in Randwick to a waiting vehicle.

He was handcuffed at his hands and ankles.

NSW Department of Corrective Services' extreme high security escort unit then drove Milat to nearby Long Bay jail where media was also waiting.

He was seated in the back of the vehicle facing backwards and behind tinted windows.

Milat has spent the past two weeks at the hospital receiving treatment for terminal cancer.

He had previously been housed at Goulburn Supermax.

Milat was flanked by corrective services officers when he was transported. ( ABC News )

Milat was taken to hospital earlier this month, where several lumps were found in his stomach and throat.

He is serving seven life sentences for the murder of seven backpackers in the 1990s.

The bodies of the backpackers, aged 19 to 22, were discovered buried in the Belanglo State Forest in southern NSW between 1992 and 1993.

All had set out along the Hume Highway, near Liverpool, in order to hitchhike south.

Milat was convicted in 1996 but has always maintained his innocence and unsuccessfully made an application to the High Court for an appeal in 2004.

Ivan Milat owned a property in the vicinity of the Belanglo State Forest.

The NSW Corrections Commissioner Peter Severin said he hoped Milat would talk to police during his final days, to shed light on other crimes he may have committed.

"I personally would be very keen for Mr Milat to come forward with the information that he is still refusing to share with the people of NSW and the larger Australian community," he said.

He said he would facilitate any requests from police to speak to Milat.

Corrective Services said there were no plans to move Milat back to Supermax in Goulburn where he has been imprisoned for the past 22 years.