Brad Pitt brought some red-hot star quality to the cold open of “Saturday Night Live … At Home.”

The “Once Upon a Time … in Hollywood” Oscar winner donned a silver wig to play White House coronavirus task force advisor, Dr. Anthony Fauci, ruminating on President Donald Trump’s handling of the COVID-19 crisis.

Following Trump’s much publicized comments about UV light and disinfectant injections, Brad-as-Fauci grimaced: “I know I shouldn’t be touching my face, but …”

After a few predictable digs, Pitt, 56, whipped off his silver wig and praised America’s health-care workers on the frontline — and Dr. Fauci’s “calm and clarity” — before declaring: “Live, kinda, from all across America, it’s Saturday night!”

After some sketchy moments in the first canned “Saturday Night Live … At Home” episode forced by the coronavirus lockdown, NBC’s venerable comedy franchise rallied to give it another virtual go this weekend.

Viewers were obviously hungry for it: The first “At Home” installment two weeks ago pulled 6.7 million viewers, making it the second-highest rated episode since ‘80s cast breakout Eddie Murphy’s much ballyhooed return to the 30 Rock stage scored 10 million viewers in December 2019.

Also of note: Earlier this month, when CNN’s Alisyn Camerota, 53, asked Fauci, 79, who should portray him should he ever be lampooned on “SNL,” the director of the National Institute of Allergy and Infectious Diseases grinned and quipped, “Oh, Brad Pitt — of course.”