After a series of horseplay from the Colorado Buffaloes to the Michigan Wolverines, there is no shortage of monkey business leading up to their meeting Saturday.

First, the Buffaloes trolled the Wolverines with their uniform combo for the game. Next, they gave Harbaugh & Co. a taste of their own medicine with a mock depth chart featuring the likes of Austin Powers and Lloyd Christmas. This is where things got fun.

You could say the Buffs are the persistent little brother egging for a response while poking at big brother Michigan. If a response is what they were looking for, they got it. Michigan replied to the depth chart.

That was a definite jab at the Buffs' "Dumb and Dumber" combo at punt returner. Time to make things personal.

.@UMichFootball Lloyd Christmas really wants a pair of Harbaugh khakis. Can you hook him up? pic.twitter.com/w2btMKQvN8 — Colorado Football (@RunRalphieRun) September 13, 2016

Oh, yes. They brought Jim Harbaugh's khakis into it. But Michigan was still prepared to play along.

If you're sensing another Lloyd Christmas gif as a response, you're on target.

. @UMichFootball not even a one in a million chance? pic.twitter.com/oYr2uNxHTy — Colorado Football (@RunRalphieRun) September 13, 2016

But big brother has had enough.

Little brother can't stop and won't stop, so he brings in left tackle, aka South Park's Eric Cartman, to lay down the law.

.@UMichFootball quit picking on our punter. Left tackle to the rescue. pic.twitter.com/E78bHLnzHx — Colorado Football (@RunRalphieRun) September 13, 2016

But there's plenty more on the roster for Michigan to take a jab at.

.@RunRalphieRun Better make sure your safety is good to go. Seems a bit fragile. #GoBlue pic.twitter.com/szOZXQj4DH — Michigan Football (@UMichFootball) September 13, 2016

Ouch. That might have hit a nerve for the Buffs. No worries; these guys are not short in the comeback department.

.@UMichFootball nobody playing behind this guy should be considered fragile. pic.twitter.com/HZ3Ws9QBCg — Colorado Football (@RunRalphieRun) September 13, 2016

But Michigan aka big bro is likely over these shenanigans.

But Colorado started this. Time to end this thing with a mic drop.

.@UMichFootball we'll try not to burn the House to the ground ... again. pic.twitter.com/kI2cu7t8z2 — Colorado Football (@RunRalphieRun) September 14, 2016

Are the Buffs' tactics brilliant or setting them up for a beating from the big, bad wolf?

If the Buffs are as clever on the field as they are on paper, who's to say they can't pull a "Home Alone" and leave the Wolverines landing on their khakis?

-- Courtney Schellin