CINCINNATI (AP) — Right-hander Johnny Cueto has been scratched from his start against the Colorado Rockies, his second setback of the season.

The Reds planned to call up right-hander Pedro Villarreal, who was on turn to start for Triple-A Louisville. The 25-year-old pitcher made one relief appearance for Cincinnati last season. Wednesday’s start will be his first in the majors.

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Cueto was on the disabled list from April 15 to May 19 with a strained muscle in his back. He made three starts after his return, going 2-0 with a 1.80 ERA. He allowed only one hit in eight innings of a 6-0 win in Pittsburgh on Friday.

The Reds didn’t immediately comment on his medical problem or whether he would be going back on the disabled list.