From the Department of Medicine, University of Minnesota, Minneapolis (J.D.A., W.M.S.); the Department of Medicine, Regions Hospital, St. Paul, MN (J.D.A., W.M.S.); and the Program on Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (A.S.K.).