Spike Lee said Hillary Clinton’s “entitlement” was her undoing in the 2016 presidential campaign, adding that the Democratic nominee got too comfortable assuming she was going to win.

Speaking with The Hollywood Reporter at the Cannes Film Festival on Sunday, Mr. Lee cited the 2017 book by Jonathan Allen and Amie Parnes, “Shattered,” about Mrs. Clinton’s “doomed” Democratic campaign.

“Have you read the book ‘Shattered?’ Great book,” Mr. Lee said. “Hillary comes with entitlement. They thought they were entitled to this and despite what you might think, you gotta work. If you’re chilling at Martha’s Vineyard, and think ‘It’s a done deal.’ But it wasn’t.

“There’s one thing you can learn from sports,” he said. “To quote Yogi Berra: ‘It ain’t over ‘til it’s over.’ They thought it was theirs. S—t don’t work like that.”

Mr. Lee, who endorsed Mrs. Clinton’s Democratic rival Bernard Sanders during the primaries, wouldn’t say outright whether he switched his support to the nominee. Asked if he ended up voting for Mrs. Clinton, the film director reiterated, “S—t don’t work like that.”

Mr. Lee also had some choice words for President Trump.

“He’s not my president,” he said. “I call him Agent Orange. There was some clip I saw yesterday of him dancing with the Saudis that was just ludicrous. Not only is he not a good president, he can’t dance either. He could be impeached on his rhythm. He’s the clown with the nuclear codes.”

Mr. Lee may be a little disenchanted with current politics, but that doesn’t mean he’s ready to cast a vote for Dwayne “The Rock” Johnson, who has toyed with the idea of running for president in 2020.

“How about The Rock in 2020?” The Hollywood Reporter asked.

“No,” Mr. Lee responded. “Well, I’d need to know how he stood on issues. The thing is, everyone thinks they can be president. Like, ‘Look, that guy did it.’”

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