The August 2019 issue of Toxicological Sciences features contemporary reviews on cancer chemoprevention and predicting human infection risk. Tox Spotlight articles include identifying genes required for AHR receptor-dependent induction of CYP1A1 using a CRISPR/Cas9 whole-genome screen (an Open Access article); assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes; measuring sensitivity to in vitro inhibition of CYP19 activity in freshwater fishes; and examining the role of TGFβ1 receptor antagonist GW788388 in mice. There also are Open Access articles on a new web portal for integrating mechanistic and toxicogenomic study results; the validation of GARD™skin Assay for chemical skin sensitizer assessment; and the role of quizalofop-p-ethyl in 3T3-L1 adipocytes.

Highlights of Toxicological Sciences Volume 170, Issue 2:

Toxicological Sciences is the official journal of the Society of Toxicology (SOT), a professional and scholarly organization of more than 7,800 scientists from academic institutions, government, and industry representing the great variety of individuals who practice toxicology in the United States and other countries.