FREDERICKSBURG, Pa. — Multiple fatalities have been reported in a pileup police say involves more than 50 vehicles on Interstate 78 in central Pennsylvania.

The crash happened about 9:45 a.m. Saturday in the eastbound lanes of the interstate in Bethel Township, about 75 miles northwest of Philadelphia.

The pileup left tractor-trailers, box trucks and cars tangled together across three lanes of traffic and into the snow-covered median.

The Pennsylvania Emergency Management Agency says an emergency operation center was activated and a shelter set up.

Agency spokesman Cory Angell said drifting snow has been reported in the area and officials are investigating whether that may have had something to do with the crash.

Angell said drivers are urged to use caution due to the drifting snow and extremely cold temperatures.