Square Enix recently registered warfornosgoth.com, which should be familiar to anyone who has played the Legacy of Kain series.

All we know is the name of the domain at the moment, which doesn't offer many clues, but Nosgoth is is where the Legacy of Kain series takes place. And Square Enix is the current owner of the Legacy of Kain intellectual property, so if there were to be a new entry in the series, it would be coming from them.

The last we heard of anything Legacy of Kain related, was in the form of DLC for Lara Croft and the Guardian of Light.