Promoting a non-weed-based film, the 2011 release of 50/50, Seth Rogen made an appearance on The Late Show in September 2011 to sit down with David Letterman for an interview. Before discussing the film, Letterman asked Seth about his personal life and his trend of making films centered on marijuana use. Seth describes how marijuana is part of his life and the lives of those around him.

Letterman: "In your own life, what percentage of the day are you loaded?"

Seth: "Uh, I wake up and go to the bathroom, so that takes 20 minutes. I don't know what percentage 20 minutes is but subtract that from 100 and pretty much that amount of time."

Letterman: "Really?!?"

Seth: "No, no, not at all."

Letterman: "Now what about your fiance? Does she share this interest?"

Seth: "Uh not really, probably a little more since she started dating me. I think I'm a bad influence. I either get you to start smoking weed or I make you stop smoking weed. I will do one of those two things to you."

Letterman: "Now how old were you when you began?"

Seth: "I was around 13 years old, which is pretty young, but I'm fine so I wouldn't worry about it."