CRS Methode

Metabolism – what is it? Metabolism is the sum total of all biochemical and biophysical processes. It is different from person to person as well as in each stage of life and depends on many other factors such as e.g. physical strain, illness and stress. Therefore, by means of metabolic analyses, you can obtain comprehensive knowledge on the current state of health of the human organism.



The CRS-system identifies the cellular metabolism that is the basis of a healthy life. On the one hand, the cells decompose food components for generating energy for the other metabolic processes. On the other hand, the cells use the food components for maintaining their structure and function. In all, more than 500 different metabolic reactions take place in each cell that have to be regulated – so that it all takes place in a controlled way.

Measurement in the tissue The tissue is an aggregation of cells that fulfil a certain task together. Most of the body’s cells are united into tissues. Changes in the metabolism or impaired cell functions specifically influence the composition of tissue fluid. This is why the tissue is best suitable for measuring both transient changes in the cellular metabolism due to physical or mental stress and disorders of the metabolism on account of organic lesions or diseases.



The outer skin is divided into three main layers: epidermis, dermis and subcutis. The CRS-system measures the luorescence of a large number of metabolic substances found in the epidermis and dermis such as, e.g., ATP, tryptophan, NADH, NADPH and many more.

Fluorescence measurement in medicine Up to now, metabolic analysis has been using the result of several individual examinations. They include extensive laboratory analyses of organ activities, of immune system, hormone system, lipid metabolism, mineral metabolism etc. These examinations are very time-consuming and expensive.



Modern biomedicine has recognised that a large number of metabolic products (e.g. ATP, tryptophane, the coenzymes NADH, NADPH, flavins, porphyrins that contain zinc and are free of metal and many more) emit a highly characteristic spectrum of electromagnetic beams after excitation with light (fluorescence). The intensity of the measured signal is the measure for the quantity of the respective substance in the zone of measurement. This phenomenon has been used successfully in medicine for a long time, e.g. in diagnostics for early detection of malignant cell changes on the skin. The non-invasive CRS-analysis system was developed based on the findings of fluorescence. Fluorescent metabolic substances are measured in the tissue of the ball of the thumb and quantified using an optical measuring instrument. This makes it possible to detect regulatory disorders of the cellular metabolism early.

Measured substances Among others, substances for calculating the parameters include:

ATP supplies energy for all processes taking place in the cells such as e.g. the synthesis of organic molecules or the active substance transport through the biomembrane; it serves as substrate for kinases that play a key role in the cellular metabolism and its regulation. FAD is a coenzyme and electron carrier in several cellular metabolic processes (oxidative phosphorylation, ß-oxidation of fatty acids as well as other redox reactions); in contrast to NAD, FAD transfers single electrons so that oxidoreductases can activate molecular oxygen using FAD. GTP plays an important role in the cell as energy store and for protein biosynthesis. In the citric-acid cycle, the energy produced from carbohydrates and fat is transferred to GDP resulting in GTP. By means of the enzyme guanosine diphosphate, GTP can also be transformed into the cellular messenger cGMP that, among other things, plays an important role in the regulation of the glucose level. Tryptophan is an essential amino acid that is taken in with food. It serves the body’s own synthesis of serotonin that can be inhibited by various factors such as e.g. vitamin B6 and/or vitamin B3 deficiency, insulin resistance, magnesium deficiency, but also by stress. NADPH serves as supplier of electrons and hydrogen in the anabolism as reducing agent e.g. in the synthesis of fatty acids; it is created through direct oxidation of glucose-6-phosphate in the synthesis of pentoses and is directly proportional to sugar concentration. Kynurenin is a metabolite of tryptophan and is transformed into nicotinic acid and NAD+ depending on vitamin B6. It has a strong neuroprotective effect.

The CRS-system uses the measured fluorescence intensities in special algorithms derived from comparative measurements on complex RSA (redox serum analysis). However, since the measured intensities depend on the quantity of light radiating onto the tissue and thus on the patient’s skin conditions, the CRS-system does not use any absolute values, but the ratios of the individual substances. The ratios of the metabolic substances give information on changes in and/or strains on various metabolic functions. This is how the CRS-system gives the opportunity of measuring cellular metabolic regulation in vivo.

How does the CRS work?

The screening method requires no blood sample - it is painless and can be performed within seconds.

The fluorescence of endogenous metabolic substances is registered non-invasively using a measurement probe. The measurement is done on the ball of the person's left or right hand.

The information collected is transferred to a user-friendly software for evaluation.

Scientific background The CRS has been developed by physicians and natural scientists having many years of experience in molecular biology, biochemistry, molecular metabolic diagnosis and regulation medicine.



The non-invasive CRS constitutes the further development of the so-called RSA – redox serum analysis measuring the redox potential in serum samples. To this effect, the serum samples are first incubated with defined metabolites and/or stress factors. Statements on the current metabolic situation and its strain through certain stress factors are possible on account of the measured and calculated values. At present, the RSA data pool includes more than 1.2 million measurements the statements of which have been confirmed by clinical diagnoses. RSA has been used successfully in medical diagnostics and prevention already for a long time.



Since the use of RSA is associated with invasive sampling, the non-invasive CRS-system has been developed since 1997 in comparative measurements to the RSA. The development has been supported by the German Federal Ministry of Economics and Technology.



The CRS is available as target group-specific version for the fields of medicine and high-performance sports (CRS-med) as well as for the fields of fitness, spa, pharmacy and nutrition (CRS-prevent).

Quality you can rely on! The CRS-system is a class IIa medical device with the CE marking CE 0535.

We can therefore confirm that our CRS-system corresponds with the currently valid European guidelines. Compliance with the demanding requirements in the area of health protection, performance and safety for patients, users and third parties is our top priority and has been proven by a so-called conformity assessment procedure. Regular checks by the 'notified body' ensure that the high degree of quality and safety is maintained and processes are continually improved.

Trust and satisfaction through convincing products, best quality and distinctive customer orientation – we provide the key to your success!

Which measurement results does the CRS® system provide? Protection from metabolic acidosis

Immune resistance

Metabolic regulation

Physical training status

Protection from oxidative stress

Mental stress capacity

Protection from infectious processes

Connective tissue condition

Regulation of inflammatory processes

Allergic activation

Cell regeneration processes

Cell reduction processes

General performance capability

Micronutritional requirements