"He was truly an inspiration. His heart-warming friendship with players and staff alike epitomised the impact this wonderful little boy had on everyone he met.

"He had a special relationship with Jermain Defoe and their feelings for each other were evident for all to see.

"Jermain, naturally, is heartbroken. Bradley's story not only touched our club and our fans, but also the wider football community.

"Football can be a powerful force for good and our sport came together to embrace Bradley's fight in a unique way."

Bradley's family had close links with Everton after the club pledged £200,000 towards his treatment when he was mascot for the match between Sunderland and the Toffees.

He went on to be a mascot for the Merseyside club too.

Chairman Bill Kenwright said: "One of football's all-time greats. We are so privileged to have known him...and will always be proud that he chose us as his second club.

"We send our loving thoughts to his mam and dad and his family...plus those who were inspired by him throughout the world of football.

"Especially our friends the supporters, team and staff at Sunderland AFC. And of course his beloved Jermain. Respect!! Bradley Lowery. There's only one Bradley Lowery."