MINNEAPOLIS — The Knicks’ 115-99 blowout loss to the Timberwolves on Wednesday night could be the last time they play without Andrea Bargnani and Jose Calderon.

The Knicks are laying the groundwork not only for Bargani to make his season debut Saturday against the winless Sixers but also for Calderon to join him.

There have been so many setbacks along the way, Knicks coach Derek Fisher is being cautious about penciling them in for Saturday. But it’s in the designs.

The Knicks won’t officially practice Thursday, but Calderon and Bargnani are expected to conduct a 3-on-3 scrimmage with Fisher bringing in some younger players to participate. Friday’s practice will feature a full-blown scrimmage after which it will be determined if Calderon’s calf injury and Bargnani’s hamstring injury are history.

Calderon said he expects to be cleared for contact by doctors Thursday.

“After that we make a decision,’’ Calderon said.

Calderon hasn’t played since the fifth preseason game, missing the final two. He thought he would be back for the season opener, but reinjured his calf during warmups before the game three weeks ago. The Knicks then announced a two-to-three week timetable for his return.

“I know wins and losses are not on our side but we’re getting where we want,’’ Calderon said. “But we got to do it for 48 minutes. We’re right there, fighting. We’re close. I can only be myself, get everyone comfortable out there. Pass ball to the open guy. Shoot the ball when I’m open, try to get everyone organized. That’s my job.’’

Bargnani hasn’t played since the preseason opener after tweaking his hamstring, an injury the Knicks thought would force him to miss only one game.

“Not that I can say expect to [have them back Saturday], we’re just focused on (Minnesota),’’ Fisher said before tip-off at Target Center. “We have a couple of days to get some work in practice in and see from there. I’ll worry about who may or may not play Saturday after [Wednesday].’’

The Knicks have tried to salvage the first 13 games with a struggling Shane Larkin as starting point guard and a rotating crew at starting power forward. (Wednesday’s choice was Quincy Acy).

It might be time for Larkin to go back to the bench and learn. The brutal November schedule hasn’t helped the speedy former University of Miami guard. He could fall out of the rotation with Pablo Prigioni playing well.

“I’m not sure what’s going to happen to me,’’ said Larkin, who scored four points in 29 minutes against Minnesota. “To be determined. I think [Jose’s] coming back sometime this week. But we’ll see what happens.’’

During the Knicks’ fourth-quarter comeback in Tuesday’s 117-113 loss in Milwaukee, there was some debate about Tim Hardaway Jr.’s intentional foul with 30 seconds left and the team down three.

“We wanted to go ahead and give a foul thinking we had another foul to give,’’ Fisher said. “We didn’t have a foul to give. He missed one, made one. I talked to the guys about that particular play. It’s still in line with my philosophy as I’ve watched games over the years and thought about what I’d do in those situations, down three with 30 seconds to go, if don’t get a stop, they score and it’s over. I’d rather extend the game.’’

Iman Shumpert regressed after a solid game in Milwaukee, going 1 of 11 from the field with three points.

Wednesday marked the first the Knicks have seen of this season’s No. 1-overall draft pick, 6-foot-8 forward Andrew Wiggins, one night after facing No. 2 pick Jabari Parker of Milwaukee.

“He enjoys playing defense,’’ Fisher said of Wiggins. “That’s a skill in itself. It’s good to see guys in the league who understand talent is a lot focused on the offensive end, but defense is part of being successful.’’