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Deadpool is once again roaming the streets of Vancouver — expect havoc to follow.

Local production on the sequel to Ryan Reynolds’ 2016 Vancouver-filmed blockbuster is underway with shooting scheduled to begin Tuesday night in Coal Harbour.

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Film notices for Deadpool 2, which is using a pair of production titles (Caribbean Blue and DAISY), have been plastered around downtown Vancouver.

On Tuesday night, between 7 and 11 p.m., crews will be shooting a rooftop scene on the small tower at 1090 West Pender Street.

Cranes with lights will be in place on Thurlow and Cordova to illuminate the set. The area will be “brighter than usual,” according to the production notices.

A drone will also be used for filming above 1090 Pender and 500 Thurlow Street.

Photo by Arlen Redekop / Postmedia

Deadpool 2 moves to Gastown on Wednesday, Thursday and Friday with the 300 block of Cambie Street being used as the site for various scenes of Marvel mayhem featuring crashes and a character getting hit by a car.