Premature babies in Aleppo have been removed from their incubators after air strikes destroyed hospitals across the city, prompting condemnation of the Syrian government and Russia by the US and the UN.

Harrowing video footage shows tiny babies being removed from their incubators in a smoke-filled ward, with nurses reduced to tears as they detach the tubing providing support and wrap the babies in blankets.

A photograph provided to The Independent by a Syrian journalist shows premature babies later lying under a blanket on the floor – apparently in a civilian house – with medical tubes around them as a nurse tries to provide them with some form of support in a bid to keep them alive.

Premature babies removed from incubators and treated on the floor of a civlian home after the bombing of an east Aleppo hospital ( (Yasser Al-Rahil)

The children’s hospital was destroyed on Thursday on the third day of a renewed assault by the Syrian regime and Russia against opposition-held districts in Aleppo.

Four other hospitals in the east of the city and the surrounding rebel-held countryside have also been hit and damaged since the offensive began on Tuesday, with Syria’s health directorate and the World Health Organisation (WHO) reporting that all hospitals in the besieged part of the city are now out of service.

The death toll has reached at least 92 people since the start of the offensive, according to the UK-based Syrian Observatory for Human Rights.

At least 27 people, including children, were killed in eastern Aleppo on Saturday alone in intense air strikes, barrel bombs and artillery rounds, according to the Observatory. The death toll is expected to rise due to the number of seriously wounded.

Saturday’s bombardment destroyed rescue and medical facilities in eastern Aleppo, while schools in the area, many of which operate from basements due to frequent attacks, announced in a statement they would be closed on Saturday and Sunday “for the safety of students and teachers, after the barbarous aerial strikes.”

“People went to sleep to the sound of bombardment and awoke to the sound of bombardment,” Rami Abdel Rahman, head of The Observatory told AFP. “There’s barely a neighbourhood that has been spared. People don’t leave their homes.”

Yasser Al-rahil, journalist and member of the Revolutionary Forces of Syria media office, who provided the photograph to The Independent, said the recent bombardment of hospitals was resulting in high numbers of injured people dying in the hours after they are hurt.

Mr Al-rahil told The Independent: “We have counted more than 2,000 artillery shells and nearly 250 air strikes since midnight on Friday, which have left 28 dead and 150 wounded.

“The number of people dead is increasing due to the fact that many of the wounded are in a serious condition and there is no adequate treatment. All hospitals in the liberated areas are out of service as a result of systematic shelling over the past two days, so the wounded are being treated anywhere available away from the bombing.”

Following the latest assaults by the regime the US National Security Advisor Susan Rice condemned “heinous” bombings of hospitals in rebel-held eastern Aleppo Saturday, warning the regime and its Russian backers they are responsible for long term consequences.

Mr Rice said in a statement: “The United States condemns in the strongest terms these horrific attacks against medical infrastructure and humanitarian aid workers. There is no excuse for these heinous actions.

“The Syrian regime and its allies, Russia in particular, bears responsibly for the immediate and long term consequences these actions have caused in Syria and beyond.”

In pictures: Aleppo bombing Show all 14 1 /14 In pictures: Aleppo bombing In pictures: Aleppo bombing Bombing in Aleppo Smoke rises after airstrikes on the rebel-held al-Sakhour neighborhood of Aleppo, Syria April 29, 2016. Reuters In pictures: Aleppo bombing Bombing in Aleppo A Syrian family runs for cover amid the rubble of destroyed buildings following a reported air strike on the rebel-held neighbourhood of Al-Qatarji in the northern Syrian city of Aleppo, on April 29, 2016. AFP/Getty Images In pictures: Aleppo bombing Bombing in Aleppo A man reacts as he stands on blood stains at a site hit by airstrikes in the rebel held area of Aleppo's al-Fardous district, Syria, April 29, 2016. Reuters In pictures: Aleppo bombing Bombing in Aleppo The damage of the airstrikes in the rebel-held area of Aleppo on April 28 Reuters In pictures: Aleppo bombing Bombing in Aleppo The damaged the Medecins Sans Frontieres (MSF)-backed al-Quds hospital after it was hit by airstrikes, in a rebel-held area of Syria's Aleppo Reuters In pictures: Aleppo bombing Bombing in Aleppo Syrians evacuate an injured man amid the rubble of destroyed buildings following an air strike on a rebel-held of Aleppo on April 29, 2016. AFP/Getty Images In pictures: Aleppo bombing Bombing in Aleppo People inspect the damage at a site hit by airstrikes, in the rebel-held area of Aleppo's Bustan al-Qasr AP In pictures: Aleppo bombing Bombing in Aleppo A man leads a woman in tears and child out of the scene after airstrikes hit Aleppo AP In pictures: Aleppo bombing Bombing in Aleppo Civil defence members search for survivors after an airstrike at a field hospital in the rebel held area of al-Sukari district of Aleppo Reuters In pictures: Aleppo bombing Bombing in Aleppo A Syrian boy is comforted as he cries next to the body of a relative who died in a reported air strike in the rebel-held neighbourhood of al-Soukour in the northern city of Aleppo Getty Images In pictures: Aleppo bombing Bombing in Aleppo A Syrian family walks amid the rubble of destroyed buildings following a reported air strike in the Bustan al-Qasr rebel-held district of the northern Syrian city of Aleppo Getty Images In pictures: Aleppo bombing Bombing in Aleppo Syrian civil defence volunteers and rescuers remove a baby from under the rubble of a destroyed building following a reported air strike on the rebel-held neighbourhood of al-Kalasa in the northern Syrian city of Aleppo Getty Images In pictures: Aleppo bombing Bombing in Aleppo Syrians help a wounded youth following an air strike on the Fardous rebel held neighbourhood of the northern Syrian city of Aleppo Getty Images In pictures: Aleppo bombing Bombing in Aleppo Syrian civil defence volunteers evacuate people from a damaged building following a reported airstrike in the rebel-held neighbourhood of Tareeq al-Bab in the northern city of Aleppo

In response to the statement Mr Al-Rahil told The Independent the Syrian people in the east of Aleppo were “tired of words from the international community”, saying: “We do not want to condemn it. We want to stop this holocaust in Aleppo.

“Civilians in eastern Aleppo are tired of words from the international community. They want Russia and the Assad regime to stop bombing them.”

Two top UN officials said they were “extremely saddened and appalled by the recent escalation in fighting in several parts of Syria.”

Humanitarian coordinator for Syria Ali al-Za’atari and regional humanitarian coordinator Kevin Kennedy also said they had shared a plan to deliver aid, and evacuate the sick and wounded from east Aleppo.

“It is imperative all parties agree to the plan and allow us to secure immediate, safe and unimpeded access to provide relief to those most in need,” they said.

Both Russia and Assad’s government have denied deliberately targeting hospitals and other civilian infrastructure during the war, which began in 2011 and was joined by Russia’s air force in September 2015.

The charity Doctors Without Borders said in a message there had been more than 30 hits on hospitals in eastern Aleppo since early July and that medical supplies had been “depleted” with “no possibility of sending more supplies in”.

Health and rescue workers have previously been able to bring damaged hospitals back into operation but a lack of supplies is making that harder.