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Her decision comes as Kavanaugh is facing questions about a decades-old sexual assault allegation.

But McCaskill said while the alleged incident is "troubling," her decision to oppose him is based on his positions on the "avalanche of dark, anonymous money that is crushing our democracy."

"It is his allegiance to the position that unlimited donations and dark anonymous money, from even foreign interests, should be allowed to swamp the voices of individuals that has been the determining factor in my decision to vote no on his nomination," McCaskill said in a statement.

She added that she is also "uncomfortable about his view on Presidential power as it relates to the rule of law, and his position that corporations are people."

McCaskill's decision to oppose Kavanaugh comes as she's facing a tough reelection in Missouri in November where national Republicans and her opponent, state Attorney General Josh Hawley, has tried to make the Supreme Court fight a key issue in the race.