PORT Adelaide will roll out a new-look side with four debutants for its season-opener against Melbourne at the MCG on Saturday.

Power coach Ken Hinkley confirmed on Tuesday that first-round draft picks Connor Rozee, Zak Butters and Xavier Duursma will all take on the Demons, along with third-year midfielder Willem Drew.

Marquee recruit West Coast premiership-winning ruckman Scott Lycett and former Hawthorn defender Ryan Burton will also play their first games for the Power.

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All up, the Power will have 11 changes to the team that lost to Essendon in round 23 last year.

"It makes it hard for Melbourne to predict what we're going to do, because we don't know what we're going to do," Hinkley told reporters.

"It's incredibly exciting, there's no doubt about that."

Rozee was the fifth overall pick in last year's NAB AFL Draft, Butters was the off the board at pick 12 and Duursma completed the Power's haul with the 18th selection.

Drew – a second-round pick in the 2016 draft – missed most of last season with an Achilles injury, but has made the most of his opportunity in the absence of injured co-captain Ollie Wines.

"They're usually pretty bulletproof, young people, they have a lot of confidence," Hinkley said.

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"They've had a pre-season where they've played and trained and done everything amongst AFL players the whole pre-season.

"We've seen their form in JLT against the next best thing, and that's opposition, and they've done really well in that, so we're comfortable that they're ready to go.

"Drew is slightly different, he's a more mature player, but the three younger boys are high picks.

"I don't think you can ever sit there and say all three are going to play round one, but I've always said, first-round picks now, more often than not, they nearly play, I'm talking top-10, top-12."

Hinkley informed the players of their selection at a team meeting on Tuesday morning before training.

"They're not picked because they're young, they're not picked because they're high draft picks, they're picked because they can play really good football already and we think they can have an impact straight away," he said.

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"Whether that be in pressure, whether that be in ball use, whether that be as part of the team, I'm sure they can have an impact straight away.

"What a great place to play your first game – the MCG – so it's pretty exciting."

The Power almost handed a seventh player his club debut, but Hinkley said former Brisbane winger Sam Mayes narrowly missed out on selection.