He started out in a band called "Disque Attack" as the drummer, which was very much a new wave rock band. At 18, Cook went to University to study British Studies. During this time he began DJing on the Brighton club scene.

He had his first solo hit in 1989 called "Blame It on the Bassline", which featured the future Beats International member MC Wildski. It reached 29 on the UK Singles Chart.

In 1996 Cook first took on his Fatboy Slim persona. His first album as Fatboy Slim and second solo album was called "Better living Through Chemistry", which was released with Skint Records. It had the Top 40 UK hit single "Everybody Needs a 303".

In 2000 he released his third studio album called "Halfway Between the Gutter and the Stars", which also became an award winning video. The following year Fatboy Slim won six awards for "Weapon of Choice", which was the most awards won at the ceremony that year.

Cook also produced the single "Mama Do the Hump" for Rizzle Kicks, which got to number two on the charts. He also reached number 3 in the UK charts with his single "Eat, Sleep, Rave, Repeat" in 2013.That same year he performed at one of the open air concerts on Brighton Beach, in front of over 250,000 people.

On 6th March 2013, Fatboy Slim performed at the House of Commons in London for the first time, in aid of the Last Night A DJ Saved My Life Foundation. And in May 2014 he played in Essex at the We Are FSTVL, playing for nearly two hours, the biggest act at the event.

Cook was also awarded a star on the City of Brighton's version of the Walk of Fame alongside Winston Churchill.