Oak Alley is not known for its haunting, unlike the nearby Myrtles Plantation, but there have been many reports by guests and staff to rationalize questions. Plantation homes, due to their rough nature, seem to be a common theme for ghost sighting and reports. Reports have come in that workers late at night often see a figure of a lady throughout the mansion. After checking old photographs this lady is said to be either Josephine or Louise Roman. Tour guides also report seeing a figure of a man wearing a grey suit and riding boots, common apparel for Jacque Roman III, roaming the home as well as in a mirror. Another peculiar sighting was that believe to be Josephine Stewart, the last homeowner who really loved Oak Alley. It was well known that Josephine's favorite room during her time at Oak Alley was the lavender room. This is fitting as staff have often reported seeing a woman sitting on the edge of the bed in this room. After being asked to identify the woman, the description fit Mrs. Stewart perfectly. Whether these apparitions are in fact the former inhabitants of this home will probably never be certain, but it is curious that the descriptions fit their profiles.

The plantation has also been investigated by numerous popular and well respected paranormal investigation teams. Including the Sci-Fi network's Ghost Hunters, and Travel Channel's Ghost Adventures teams. TAPS revealed that they believe the property to be haunted with "neat little activity." This was certainly not their most activity ridden investigation, but it did give a fundamental history and tour of the home.

Most of the reported "activity" has come from staff members of the plantation claiming to have been touched or feel an eerie presence around them while working night shifts. Whether this is simply a marketing device by the business, because let's not forget that this is a business, or a legitimate playground for the paranormal, the property is absolutely spectacular. Oak Alley now functions as a bed and breakfast with hourly tours. It also serves as an extremely popular location for weddings due to the oak lined alley in front of the home creating a perfect backdrop.