Prince Andrew once called accuser Virginia Roberts Giuffre a “very sick girl” — and said he could “shrug and move on” from her damning accusations against him, according to a report Sunday.

The royal made the alarming comment to a concerned pal in 2011, shortly after he was first linked to the sex scandal involving his pedophile pal Jeffrey Epstein, according to the Mail on Sunday, which says it has seen the exchange.

It is at least the second time the royal appeared to have made direct reference to Giuffre — despite claiming in last year’s disastrous BBC interview that he did not remember meeting the woman who alleges she was trafficked for sex with him three times from when she was 17.

Andrew made his comments in an exchange with his friend Jonathan Rowland who had asked him, “Hope the press isn’t getting you down to [sic] much” the paper reports.

“Not at all!” Andrew replied, according to the report.

“She is a very sick girl apparently. The innuendo is the problem. But there is nothing that one can do for that! Shrug and move on,” he reportedly claimed.

Rowland later asked him about life “in the trenches,” saying, “Hope you are surviving,” the UK paper said.

“Keeping head below the parapet!” Andrew reportedly replied to his pal.

“Been trying to engage with the media on all fronts but they won’t listen to sense at the moment. Hopefully HMG [Her Majesty’s Government] will, finally, swing in today.”

When Rowland said it is “sometimes best to ignore them and disappear for a while,” Andrew insisted it was “no time to hide,” according to the report.

A lawyer for clients suing the Epstein estate told the Mail on Sunday that it was Andrew’s “credibility at stake, not” Giuffre’s.

“Virginia’s mental health is excellent and has been throughout, although it has been severely tested by Andrew and Epstein,” the unidentified lawyer said.

Giuffre has not replied directly to the report, but has maintained her calls for the royal to talk to the FBI as part of the ongoing investigation into Epstein’s inner circle following the multimillionaire pedophile’s death last August.

“Tick Tock Andy- time to talk!!” she tweeted Friday. “The world is over the lies, the cover ups and the simple fact that privilege buys your way out of facing the music. Do the right thing, if not for me then the countless other Epstein victims who deserve the truth.”

Andrew did not respond to the paper’s requests for comment.

He was booted from royal duties in November following his disastrous attempts to justify his close links to Epstein even after his friend was convicted of child sex offenses. Just a week later, Giuffre gave her own BBC interview, doubling down on her claims that she was trafficked to have sex with the prince.

Andrew and Buckingham Palace have always vehemently denied the accusations against him.