Story highlights Tornadoes rip eastern North Carolina

Hundreds of houses damaged, thousands lose power

Agency: Conditions could be dangerous from Sunday through Tuesday

Tornadoes, wind and hail are possible throughout Midwest and South

Eastern North Carolina cleaned up Saturday from powerful tornadoes that damaged about 200 homes and knocked out power to thousands of customers.

Meanwhile, much of the central United States is bracing for even more severe weather in the form of tornadoes, damaging winds and hail.

Multiple twisters touched down in an area east of Greenville, North Carolina, to Beaufort County, on Friday evening, the National Weather Service reported.

A tornado that struck Whichards Beach in Beaufort County injured 16 people and damaged or destroyed 150-200 homes, reported the Pasquotank-Camden Emergency Management, quoting the National Weather Service.

The twister was rated an EF-3, with winds estimated at 150 mph. Emergency management official said that ended the streak of days without an EF-3 tornado at 158 days.

Photos: Photos: 10 deadliest U.S. tornadoes Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 1.The "Tri-State Tornado," which killed 695 people and injured 2,027, was the deadliest tornado in U.S. history, according to the National Oceanic and Atmospheric Administration. The tornado traveled more than 300 miles through Missouri, Illinois and Indiana on March 18, 1925, and was rated an F5, the most powerful under old Fujita scale (winds of 260-plus mph). Hide Caption 1 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 2. The "Natchez Tornado" killed 317 people and injured 109 on May 6, 1840, along the Mississippi River in Louisiana and Mississippi. The official death toll may not have included slaves, according to the Federal Emergency Management Agency. Hide Caption 2 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 3. The "St. Louis Tornado" killed 255 people and injured 1,000 on May 27, 1896, in Missouri and Illinois. It had winds of between 207 mph and 260 mph. Hide Caption 3 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 4. The "Tupelo Tornado" killed 216 people and injured 700 on April 5, 1936, in the northeastern Mississippi city. Hide Caption 4 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 5. The "Gainesville Tornado" was a pair of storms that converged April 6, 1936, in Gainesville, Georgia, killing 203 people and injuring 1,600. The tornado destroyed four blocks and 750 houses in the northern Georgia town. Hide Caption 5 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 6. The "Woodward Tornado" wreaked havoc across parts of Texas, Oklahoma and Kansas on April 9, 1947 killing 181 people and injuring 970. The funnel cloud reportedly was more than a mile wide in places. Hide Caption 6 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 7. The The tornado that struck Joplin, Missouri , on May 22, 2011, killed 158 people and injured more than 1,000. The storm packed winds in excess of 200 mph and was on the ground for more than 22 miles. Hide Caption 7 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 8. The "Amite/Pine/Purvis Tornado" killed 143 people and injured 770 on April 24, 1908. The storm left only seven houses intact in Purvis, Mississippi, and also caused damage in Amite, Louisiana. Hide Caption 8 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 9. The "New Richmond Tornado" killed 117 people and injured 200 on June 12, 1899, in New Richmond, Wisconsin. Hide Caption 9 of 10 Photos: Photos: 10 deadliest U.S. tornadoes 10 deadliest U.S. tornadoes – 10. The "Flint Tornado" killed 115 people and injured 844 on June 8, 1953, in Flint, Michigan. The tornado was the deadliest twister ever recorded in the state. Hide Caption 10 of 10

John Pack, spokesman for the Beaufort County Emergency Management, estimated more than 200 homes in that county sustained major damage, and at one point at least 2,500 homes didn't have power.

He told CNN that staffers at the National Weather Service, county volunteer fire crews and more than 100 electrical crews were working to assist residents.

In Pasquotank County, three tornadoes touched down, destroying 13 homes and causing major damage to 17 homes, the Pasquotank-Camden Emergency Management said. The weather service said those were EF-2 and EF-1 twisters.

NC Dominion Power reported 3,100 customers losing power in Pasquotank County. Elizabeth City Public Utilities said approximately 4,000 city customers lost power.

In nearby Perquimans County, the story was similar.

A spokesman for that county's emergency management agency, Tom Ponte, told CNN a preliminary assessment showed the storm damaged 38 homes and left about 1,770 residents without power.

According to Ponte, the county is opening a shelter for residents displaced by the storm and roads are being cleared by the county fire department, with assistance from the North Carolina Department of Forestry.

The National Weather Service's Storm Prediction Center , which monitors severe weather across the United States, said severe weather will move over other parts of the United States over the next three days. That's all due to a storm that's moving eastward from the Rockies.

CNN meteorologist Matt Daniels predicts a slight risk of severe storms Saturday evening from central Texas into southeast South Dakota. This may include damaging winds and large hail, but does not rule out a few tornadoes.

On Sunday, most of Arkansas and neighboring areas -- including Shreveport, Louisiana, and Springfield, Missouri -- face the highest chance of severe weather, though states as far north as North Dakota, and southeast to Georgia, also could be in harm's way.

The SPC said it may upgrade Sunday's threat level from moderate to "high risk." This would be the first "high risk" threat this year -- a warning that is typically issued only a few times a year.

The danger zone shifts farther east on Monday, with Memphis, Tennessee, and Tupelo, Mississippi, among the cities most likely to get hit.

There is also a slight risk of storms stretching into the Midwest, north Georgia and the western Carolinas. These storms could produce damaging winds, large hail and tornadoes (some could be strong) throughout the day.

And yet more severe weather looms for Tuesday.

The Storm Prediction Center notes that these threats come in a year that has been -- so far -- one of the quietest for tornadoes in U.S. history. Already, the country has set a record for going the longest into a new year without a tornado fatality.