The celeb-connected ONE campaign has put out a new PSA campaign to encourage America's youth to help fight poverty and disease.

They will make their television appearance during the Dec. 2 episode of CW's "Gossip Girl" and feature Leighton Meester, Jessica Szohr and Ed Westwick from Gossip Girl; Ashley Greene, Kellan Lutz, Nikki Reed and Jackson Rathbone from "Twilight"; Hayden Panettiere from "Heroes"; Corbin Bleu from "High School Musical"; Tristan Wilds from "90210"; John Cho from "StarTrek"; and Brandon T. Jackson from "Tropic Thunder."

“In the last election, and over the course of history, young people have shown that when we get organized and committed, we are powerful. The fight against extreme poverty and preventable disease in poor countries needs our support, our energy and our commitment,” said actress and ONE member Ashley Greene.