SYRACUSE — Eric Dungey threw for 278 yards and three touchdowns, Cole Murphy kicked a tiebreaking field goal in the fourth quarter, and Syracuse stunned No. 2 Clemson 27-24 on Friday night to put a damper on the Tigers’ chances to repeat as national champions.

Clemson (6-1, 4-1 ACC) had won 12 consecutive games on the opponent’s home field, the longest streak in school history and tied for the second longest active streak in the nation. Clemson also had won 11 consecutive games overall, the longest active winning streak in the nation, and 12 straight away from home against ACC teams. The Tigers lost their last road game of 2014 at Georgia Tech.

“We had opportunities. We didn’t take advantage of opportunities,” Clemson coach Dabo Swinney said. “They did. This is going to hurt, but you move forward.”

The Orange (4-3, 2-1) are 3-6 against the previous year’s national champion, also beating Penn State in 1987 and Michigan in 1998.

Clemson won the title last year despite a loss to Pittsburgh. That was not lost on the Tigers.

“Every goal is there for this team,” Swinney said. “We’ve got to get better from this, have the type of season we want to have.”

The Tigers took a big blow when quarterback Kelly Bryant suffered an apparent concussion in the final minute of the first half. He was knocked down hard by defensive tackle Chris Slayton and lay on the turf for a couple of minutes before being helped to the locker room. Slowed after spraining his left ankle last week against Wake Forest, Bryant passed for 116 yards and ran for minus-8 yards.

Clemson has a bye week to heal and correct its mistakes.

“I’m sure they’ll still have an opportunity to play for the national championship,” Syracuse coach Dino Babers said. “They’re a national championship team. They’re going to be fine.”

Bryant, who watched the second half from the sideline, entered the game averaging 277 yards of total offense, but noticeably favored an injured ankle as Syracuse gained a surprising 17-14 halftime lead.

Zerrick Cooper replaced Bryant to start the second half and guided the Tigers to a tying field goal.

The Tigers tried a trick play with time winding down, but Will Spiers threw an incompletion on a fake punt.

Dungey hit Dontae Strickland for a 23-yard score to open the game and also hit Ervin Philips for 66 yards in the first quarter and Steve Ishmael for 30 in the third to break a 17-17 tie.

Syracuse used big plays to stun the Tigers, hitting six of 20 yards or more as the Orange outgained Clemson 440-317. And the Orange defense limited the Tigers to 2 of 11 on third down, none more critical than Cooper’s overthrow on third down before the fake.

The Orange responded quickly as the Carrier Dome crowd rocked the building with raucous cheers of “Let’s Go Orange!” Dungey raced 45 yards down the left side and hit Ishmael on the next play for a 30-yard scoring pass.