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Standalone vs. Multi-system - which should you use?

Multi-system emulators (particularly RetroArch) have gone a long way. You can download just a single emulator to handle emulating nearly everything. For the most part, multi-system emulators replaced the need to use standalone emulators for NES, SNES, Genesis/Sega CD/32X, Game Boy/Color/Advance, Game Gear/SMS, TurboGrafx16/CD, Wonderswan/Color, PlayStation 1, and Nintendo 64.

Standalone emulators, though, are still a good option if you want something that 'just works out of the box'. They're easier to use and offer some features that multi-system emulators don't have. I recommend trying both standalone & multi-system emulators to find out which option works best for you.