Conservatives are launching an eleventh-hour effort to make changes to a White House-backed criminal justice reform bill.

The Senate is expected to take a final vote on the measure Tuesday night — but first they will have to beat back proposed changes that bill supporters are characterizing as “poison pills” meant to sink the comprehensive legislation.

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Senators are scrambling to defang the battle, which is threatening to put a spotlight on GOP infighting, and allow Republicans to bypass forcing their members to take tough votes. Supporters of the legislation say they are in talks to see if they can get an agreement to work in some amendments from GOP senators that are considered noncontroversial.

Sen. Dick Durbin Richard (Dick) Joseph DurbinFeinstein 'surprised and taken aback' by suggestion she's not up for Supreme Court fight Grand jury charges no officers in Breonna Taylor death Democrats shoot down talk of expanding Supreme Court MORE (D-Ill.) said there was broad, “general” talk “about a manager’s amendment” to work in some of the proposed changes, but no agreement had been reached.

“During the period of time where people were reading it for 24 hours, we found two or three things we wanted to change,” Durbin said. “We do have some provisions that I think are acceptable all around that we would like to add to the bill either by UC [unanimous consent] or manager’s amendment.”

He pointed to amendments from GOP Sens. James Lankford James Paul LankfordMcConnell works to lock down GOP votes for coronavirus bill Charities scramble to plug revenue holes during pandemic Warren calls for Postal Service board members to fire DeJoy or resign MORE (Okla.), related to faith-based activities, and Ted Cruz Rafael (Ted) Edward CruzCruz blocks amended resolution honoring Ginsburg over language about her dying wish Trump argues full Supreme Court needed to settle potential election disputes Press: Notorious RBG vs Notorious GOP MORE (Texas), who is looking to add additional crimes that would exclude an individual from earning credits that reduce a sentence. Both provisions would need unanimous consent to be included in the final bill.

The Senate’s criminal justice bill takes a House-passed prison reform measure and folds in a handful of alterations to sentencing laws and mandatory minimums for some drug-related felonies. It also would make the 2010 Fair Sentencing Act retroactive.

In a major boost to supporters, who have been stuck in legislative limbo for years, President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE threw his support behind the bill in November, and Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellFEC flags McConnell campaign over suspected accounting errors Poll: 59 percent think president elected in November should name next Supreme Court justice Mark Kelly: Arizona Senate race winner should be sworn in 'promptly' MORE (R-Ky.) agreed to give the legislation a floor vote after a furious lobbying campaign from the White House, advocates and members of his own caucus.

But the decision to move forward with the legislation has done little to quell opposition from the bill’s most ardent Republican opponents. McConnell acknowledged on Tuesday that there is an appetite among his caucus to make further changes to the legislation.

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“With respect to the substance of the legislation, a number of members continue to have outstanding concerns that the bill currently leaves unaddressed,” McConnell said from the Senate floor. “Members will have the opportunity to debate and vote on the pending germane amendments before we vote on final passage.”

GOP Sens. Cory Gardner Cory Scott GardnerCook Political Report shifts Colorado Senate race toward Democrat Overnight Health Care: US coronavirus deaths hit 200,000 | Ginsburg's death puts future of ObamaCare at risk | Federal panel delays vote on initial COVID-19 vaccine distribution The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting MORE (Colo.) and Pat Toomey Patrick (Pat) Joseph ToomeyAppeals court rules NSA's bulk phone data collection illegal Dunford withdraws from consideration to chair coronavirus oversight panel GOP senators push for quick, partial reopening of economy MORE (Pa.) tried to offer amendments on Tuesday and make them available before a vote, but both efforts were blocked. Gardner attempted to attach a marijuana measure to the overall bill but was blocked by Grassley. Toomey, meanwhile, was blocked by Durbin when he tried to bring up his amendment on the Crime Victims Fund.

Republican senators who say they are still weighing the bill warn that they are hearing concerns from law enforcement groups, and that those reservations are impacting their thinking.

“I’ve been glad to see there have been some changes made along the way, changes that address some of the serious concerns that I and others have raised,” said Toomey, who said he hasn’t decided whether he will support the bill. “I do think there is still room for more improvement.”

Sen. Marco Rubio Marco Antonio RubioOvernight Defense: Pentagon redirects pandemic funding to defense contractors | US planning for full Afghanistan withdrawal by May | Anti-Trump GOP group puts ads in military papers Democrats step up hardball tactics as Supreme Court fight heats up Press: Notorious RBG vs Notorious GOP MORE (R-Fla.) said in a statement that he has “heard significant concerns from local law enforcement, federal prosecutors and constituents” and that if those issues aren’t addressed through the amendment process, “I will vote no on this bill when it comes before the Senate for final passage.”

The biggest remaining hurdle is how to navigate around votes on three amendments from Sens. Tom Cotton Tom Bryant CottonGOP brushes back charges of hypocrisy in Supreme Court fight Trump uses bin Laden raid to attack Biden Battle lines drawn on precedent in Supreme Court fight MORE (R-Ark.) and John Kennedy John Neely KennedyMORE (R-La.), who are both fiercely opposed to the legislation. Because McConnell teed up the amendments late last week, the Senate will have to vote on them before they can get to a final vote on the criminal justice bill.

The Cotton-Kennedy amendments would include requiring that victims or families of victims be notified when a criminal is released. Another change would be to make publicly available rearrest data for those released, as well as information on prior offenses by those released and the crimes for which they were imprisoned.

The Kennedy-Cotton amendments would also add approximately 10 offenses to a list that excludes someone from being eligible for the bill’s earned-time credits that are designed to shorten sentences.

Sen. John Cornyn John CornynThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Liberal super PAC launches ads targeting vulnerable GOP senators over SCOTUS fight Senate GOP faces pivotal moment on pick for Supreme Court MORE (Texas), the No. 2 Senate Republican, said there are discussions with Cotton about trying to get an agreement that would allow the parts of his amendments that receive bipartisan support to be included in the final bill, known as the First Step Act.

“There’s still ongoing discussions to talk with Sen. Cotton to see if there’s areas we can agree to,” Cornyn said. “There’s some parts of his amendments that people — that I think do represent consensus, that we might be able to agree to.”

He added that talks were “in flux” but heading in the “right direction” after the Senate advanced the bill over a procedural hurdle on Monday night during an 82-12 vote.

Cotton declined to comment when asked about his amendments and any talks. But he tweeted on Tuesday afternoon, urging colleagues to support his proposed changes.

“The First Step Act provides hundreds of new rights and privileges to federal prisoners. More phone time, reduced sentences, ‘compassionate release,’ and early release credits. There is not a single benefit in the bill for the victims of these criminals,” Cotton added in a separate tweet.

Kennedy, sounding equally defiant, said he was responsible for the amendments related to victim notification and planned to go to the Senate floor with them.

“I’m going with my half rain or shine,” Kennedy said. “My half says before you let a rapist go, you’ve got to tell the woman that he raped—just a thought.”

Without a deal on potential changes to the Kennedy-Cotton amendments, senators, including a handful of Republicans, will need to join with every Democratic senator to vote them down. A simple majority is needed to include an amendment, and Republicans hold a 51-49 majority in the chamber.

Durbin warned that if the changes as currently drafted are included in the criminal justice legislation it will kill Democratic support for the measure.

“Sen. Grassley is opposed to all three of them and is going to say so publicly,” Durbin said, referring to Senate Judiciary Committee Chairman Chuck Grassley Charles (Chuck) Ernest GrassleyThe Hill's 12:30 Report: Ginsburg lies in repose Top GOP senators say Hunter Biden's work 'cast a shadow' over Obama Ukraine policy Read: Senate GOP's controversial Biden report MORE (R-Iowa). “I think others will join him.”

But Kennedy — who noted he wouldn’t support the criminal justice bill even if his changes are added — questioned how any senators could be against his proposed changes.

"I'm not going to predict that my amendment will get 51 votes, but I think it will get a fair amount of votes," Kennedy said. "I mean, how can anybody oppose telling a woman who's been raped that her rapist is going to get out of prison early?"