A 23-year-old motorcyclist has died in a crash with a sedan on Lady Denman Drive near the National Arboretum in Canberra.

Police said the man's motorcycle and the car collided just after 8:30am today, on the road which runs parallel to Parkes Way.

The road was closed between Forrest Drive and the Parkes Way downramp until midday, but has since reopened.

Investigators are at the scene to determine the cause of the crash.

Acting Station Sergeant Stephen Booth said those travelling in the car had escaped major injuries.

"The driver and passenger of the other vehicle have been taken to hospital. It's not expected they've got any serious injuries," he said.

"I'd imagine that it'd be a horrific experience unfortunately to be in a vehicle when this occurred and they'll be receiving all of the available support services that we have to offer."

Sergeant Booth urged road users to take care on wet roads.

"I'd remind all road users to please take care in poor conditions on the road. Please drive safely. We'd like everyone to get home safe and sound," he said.

This accident follows the release of a report into road fatalities which reveals about one third of ACT road fatalities and injuries involve pedestrians, cyclists or motorcyclists.

The annual ACT Road Crash Report said five of the 15 people killed on the roads last year were vulnerable road users.

The overall toll was the worst in five years.

Today's fatality takes the road toll for 2016 to six.