Rescuers stand in downtown Muenster, Germany, Saturday, April 7, 2018. A vehicle crashed into a crowd Saturday in the western German city of Muenster, killing three people and injuring 20 others. The German news agency dpa has quoted police as saying the driver of that car in Muenster has killed himself. (Bernd Thissen/dpa via AP)

Police gather in downtown Muenster, Germany, Saturday, April 7, 2018. A vehicle crashed into a crowd Saturday in the western German city of Muenster, killing three people and injuring 20 others. The German news agency dpa has quoted police as saying the driver of that car in Muenster has killed himself. (Bernd Thissen/dpa via AP)

People stay in front of a restaurant in Muenster, Germany, Saturday, April 7, 2018 after a vehicle crashed into a crowd (Stephan R./dpa via AP)

A van crashed into tables of people drinking outside a popular bar in the German city of Munster, killing two people and injuring 20 others before the driver killed himself, police have said.

A top German security official said there was no indication of an Islamic extremist motive but officials were investigating all possibilities after the deadly crash at 3.27pm local time on a warm spring day.

Expand Expand Expand Previous Next Close People stay in front of a restaurant in Muenster, Germany, Saturday, April 7, 2018 after a vehicle crashed into a crowd (Stephan R./dpa via AP) AP Police vans in downtown Muenster Photo: (dpa via AP) AP Police block a street near a place where a vehicle drove into a group of people Photo: Reuters REUTERS/ / Facebook

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Whatsapp People stay in front of a restaurant in Muenster, Germany, Saturday, April 7, 2018 after a vehicle crashed into a crowd (Stephan R./dpa via AP)

Witnesses said people ran away screaming from the city square after the crash.

Police quickly set up a large cordoned-off area for their investigation and ambulances rushed to the site.

Herbert Reul, the interior minister of North Rhine-Westphalia state, where Munster is located, said the driver of the grey van was a German citizen.

He stressed that the investigation was at an early stage but said "at the moment, nothing speaks for there being any Islamist background".

"We have to wait, and we are investigating in all directions," Mr Reul said, adding "(he) wilfully drove into a crowd of people."

Mr Reul said two people were killed in the crash and the driver shot himself dead.

That is lower than the earlier police toll of three dead plus the driver.

Police spokesman Peter Nuessmeyer told the Associated Press that he could not confirm German media reports that the perpetrator reportedly had psychological issues.

Another spokesman, Andreas Bode, told reporters that police were checking witness reports that other perpetrators might have fled from the van at the scene.

Hours later, police spokeswoman Vanessa Arlt said that "we didn't find anything (to those reports) but we're still investigating in all directions and not excluding anything".

Police tweeted that residents should "avoid the area near the Kiepenkerl pub" in the city's historic downtown area where a large-scale police operation was under way.

Officers also said they found a suspicious object in the van that they were examining to see if it was dangerous.

They told German news agency dpa that was the reason authorities cordoned off such a large area.

The Sueddeutsche Zeitung newspaper said the suspect's apartment was being searched for possible explosives.

Mr Bode said six of the 20 injured were in a severe condition.

Munster University Hospital put out an urgent call for citizens to donate blood - and so many people rushed to help that long lines of donors formed.

Jan Schoessler, who was among those in line, said dozens of people were waiting shortly after doors opened at 7pm.

The university cancelled the call after only an hour and thanked everyone on Twitter "for your overwhelming support".

Munster, a major university city, has about 300,000 residents and an attractive medieval city centre that was rebuilt after the Second World War.

TV footage showed a narrow street sealed off with red-and-white police tape.

Dozens of ambulances were near the cordoned-off area and helicopters were flying overhead.

The Kiepenkerl is not only one of the city's best-known traditional pubs, but also the emblem of the city, depicting a travelling salesman with a long pipe in his mouth and a big backpack on his back.

Ugur Hur was working at a nearby cafe in central Munster when the crash took place.

"I heard a loud bang, screaming. And the police arrived and everyone was sent out," he said. "A lot of people were running away screaming."

Lino Baldi, who owns an Italian restaurant near the scene of the crash, told Sky TG24 that the city centre had been packed with people out enjoying a Saturday market and summer-like temperatures, which had risen to 25C (77F) from just 12C (53.6F) a day earlier.

German Chancellor Angela Merkel said she was "deeply shocked by the terrible events in Munster".

"Everything conceivable is being done to investigate the crime and to support the victims and their relatives," Mrs Merkel said in a statement.

"My thanks go to all the responders at the scene."

PA Media