Not all children react to being bullied in the same way. Some children may be more predisposed to depression when bullied than are other children. Using a G × E approach, this study examined the influence of a genetic polymorphism in the serotonin transport gene (5-HTTLPR) on the victimization-depression link. The validity of the diathesis-stress versus environmental susceptibility hypothesis was tested. A total of 157 adolescents (M age = 12.21) took part in this study. For adolescents with the S,S/S,L variants, victimization was positively related to depression. No relationship between victimization and depression was found for children with the L,L variant. Findings further suggest that the influence of 5HTTLPR on the association between victimization and depression more closely follow an environmental susceptibility model.