2019

Concepts for brain aging: resistance, resilience, reserve, and compensation.Montine TJ, Cholerton BA, Corrada MM, Edland SD, Flanagan ME, Hemmy LS, Kawas CH, White LR. Alzheimers Res Ther11(1):22, 2019. PMID: 30857563.

Blood pressure circadian variation, cognition, and brain imaging in 90+ year-olds.Paganini-Hill A, Bryant N, Corrada MM, Greenia DE, Fletcher E, Singh B, Floriolli DR, Kawas CH, Fisher MJ. Front Aging Neurosci. Apr 17;11:54[Epub Apr 17, 2019].PMID: 31057391.

Apolipoprotein E/Amyloid beta complex accumulates in AD cortical synapses via apoE receptors and is enhanced by APOE4.Bilousova T, Melnik M, Miyoshi E, Gonzalez BL, Poon WW, Vinters HV, Miller CA, Corrada MM, Kawas CH, Hatami A, Albay R III, Glabe C, Gylys KH. Am J Pathol. 189(8):1621-1636. [Epub May 17, 2019]. PMID: 31108099.

Neuropsychological test norms in cognitively intact oldest-old.Melikyan ZA, Corrada MM, Dick MB, Paganini-Hill A, Kawas CH. J Int Neuropsychol Soc. 25(5):530-545, 2019. [Epub May 24, 2019]. PMID: 31122309.

White matter hyperintensities and hippocampal atrophy in relation to cognition: The 90+ Study.Legdeur N, Visser PJ, Woodworth DC, Muller M, Fletcher E, Maillard P, Scheltens P, DeCarli C, Kawas CH, Corrada MM. J Am Geriatr Soc.67(9):1827-1834.[Epub Jun 6, 2019]. PMID:31169919.

2018

Recruiting the oldest‐old for clinical research. Melikyan ZA, Greenia DE, Corrada MM, Hester MM, Kawas C, Grill JD. Alzheimer Dis Assoc Disord [Epub May 4, 2018]. PMID:29734262.

Non‐Alzheimer’s disease contributions to dementia and cognitive resilience in The 90+ Study. Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VMY, Kawas CH, Trojanowski JQ. Acta Neuropathol 136:377‐388, 2018. [Epub Jun 18, 2018]. PMID:29916037.

Sleep, hippocampal volume, and cognition in adults over 90 years old. Sabeti S, Al‐Darsani Z, Mander BA, Corrada MM, Kawas CH. Aging Clin Exp Res. [Epub Sep 3, 2018]. PMID:30178444.

Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study. Trieu T, Sajjadi ,Kawas CH, Nelson PT, Corrada MM. Neurology91(19):e1788-e1798, 2018. [Epub Oct 12, 2018]. PMID: 30315072

Positive mental attitude associated with lower 35-year mortality: The Leisure World Cohort Study.Paganini-Hill A, Kawas CH, Corrada MM. J Aging Res[Epub Nov 25, 2018]. PMID: 30595919.

2017

Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study. Corrada MM, Hayden KM, Paganini-Hill A, Bullain SS, Paganini-Hill A, DeMoss J, Aguirre C, Brookmeyer R, Kawas CH. Alzheimer Dement. 13(2):103-110, 2017. [Epub Jan 16, 2017]. PMID: 28108119.

Lower likelihood of falling at age 90+ is associated with daily exercise a quarter of a century earlier: The 90+ Study. Paganini-Hill A, Greenia DE, Perry SM, Sajjadi SA, Kawas CH, Corrada MM. Age Ageing. 46(6):951-957, 2017. [Epub Mar 21, 2017]. PMID: 28369185.

Age-related white matter integrity differences in oldest-old without dementia. Bennett IJ, Greenia D, Maillard P, Sajaadi SA, DeCarli C, Corrada MM, Kawas CH. Neurobiol Aging 56: 108-114, 2017. [Epub Apr 26, 2017]. PMID: 28527525.

Cancer – Incidence, prevalence and mortality in the oldest-old: A comprehensive review. Nolen SC, Evans MA, Fischer A, Corrada MM, Kawas CH, Bota DA. Mech Aging Dev 164:113-126, 2017. [Epub May 11, 2017]. PMID: 28502820.

Forecasting the prevalence of pre-clinical and clinical Alzheimer’s disease in the United States. Brookmeyer R, Abdallah N, Kawas CH, Corrada MM. Alzheimer Dement 14:121-129, 2018. [Epub Dec 7, 2017]. PMID: 29233480.

2016

Prevalence of Frailty and Factors Associated with Frailty in Individuals Aged 90 and Older: The 90+ Study. Lee DR, Kawas CH, Gibbs L, Corrada MM. J Am Geriatr Soc. 2016 Nov;64(11):2257-2262. PMID: 27590837.

Microinfarcts are common and strongly related to dementia in the oldest-old: The 90+ study. Corrada MM, Sonnen JA, Kim RC, Kawas CH. Alzheimers Dement. 2016 Aug;12(8):900-8. PMID: 27243907.

Sound Body Sound Mind? Physical Performance and the Risk of Dementia in the Oldest-Old: The 90+ Study. Bullain SS, Corrada MM, Perry SM, Kawas CH. J Am Geriatr Soc. 2016 Jul;64(7):1408-15. PMID: 27377238.

Impact of interventions to reduce Alzheimer’s disease pathology on the prevalence of dementia in the oldest-old. Brookmeyer R, Kawas CH, Abdallah N, Paganini-Hill A, Kim RC, Corrada MM. Alzheimers Dement. 2016 Mar;12(3):225-32. PMID: 26900132.

Synaptic Aβ oligomers precede p‐tau and differentiate high pathology control cases. Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada MM, Kawas CH, Hayden EY, Teplow DB, Glabe C, Albay R 3rd, Cole GM, Teng E, Gylys KH. Am J Pathol. 2016 Jan; 186(1):185‐198. PMID: 26718979.

2015

Brain‐derived neurotrophic factor and TrkB expression in the “oldest‐old,” the 90+Study: correlation with cognitive status and levels of soluble amyloid‐beta. Michalski B, Corrada MM, Kawas CH, Fahnestock M. Neurobiol Aging. 2015 Dec.; 36(12):3130‐3139. PMID: 26410307.

Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study. Kawas CH, Kim RC, Sonnen JA, Bullain SS, Trieu T, Corrada MM. Neurology. 2015 Jul 15. PMID:26180144.

Lifestyle Factors and Dementia in the Oldest-old: The 90+ Study. Paganini-Hill A, Kawas CH, Corrada MM. Alzheimer Dis Assoc Disord. 2015 Mar 6. PMID:25710250.

Antioxidant vitamin intake and mortality: the Leisure World Cohort Study. Paganini-Hill A, Kawas CH, Corrada MM. Am J Epidemiol. 2015 Jan 15;181(2):120-6. PMID:25550360.

2014

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Pensalfini A, Albay R 3rd, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. Neurobiol Dis. 2014 Nov;71:53-61. doi: 10.1016/j.nbd.2014.07.011. Epub 2014 Aug 1. PMID:25092575.

ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Nelson PT, Estus S, Abner EL, Parikh I, Malik M, Neltner JH, Ighodaro E, Wang WX, Wilfred BR, Wang LS, Kukull WA, Nandakumar K, Farman ML, Poon WW, Corrada MM, Kawas CH, Cribbs DH, Bennett DA, Schneider JA, Larson EB, et al. Acta Neuropathol. 127(6):825-843, 2014. PMID: 24770881.

Exponential increases in the prevalence of disability in the oldest old: a Canadian national survey. Guay M, Dubois MF, Corrada M, Lapointe-Garant MP, Kawas C. Gerontology. 60(5):395-401, 2014. PMID: 24818716.

Perforant path synaptic loss correlates with cognitive impairment and Alzheimer’s disease in the oldest-old. Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Brain. 137(Pt 9):2578-2587, 2014. PMID: 25012223. PMCID: 4132652.

Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Pensalfini A, Albay R, 3rd, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. Neurobiol Dis. 71C:53-61, 2014. PMID: 25092575.

2013

Dementia in the oldest-old. Bullain SS, Corrada MM. Neurology Continuum (Minneap Minn) 19(2 Dementia):457-469, 2013. PMID: 23558489.

DRD4 genotype predicts longevity in mouse and human. Grady D, Thanos P, Corrada MM, Barnett J, Ciobanu V, Shustarovich D, Napoli A, Grandy D, Moyzis A, Rubinstein M, Wang G-J, Kawas C, Chen C, Dong Q, Wang E, Volkow N, Moyzis R. Journal of Neuroscience 33:286-291,2013. PMID: 23283341.

Responders Versus Nonresponders in a Dementia Study of the Oldest Old: The 90+ Study. Paganini-Hill A, Ducey B, Hawk M. American Journal of Epidemiology. 2013 Apr 7. PMID: 23568592.

Amyloid imaging and cognitive decline in non-demented oldest-old: The 90+ Study. Kawas CH, Greenia DE, Bullain SS, Clark CM, Pontecorvo MJ, Joshi AD, Corrada MM. Alzheimer’s & Dementia. 2013 Mar 9:199-203. [Epub 2012 Nov 1]. PMID: 23164550. PMCID: 3604036.

Neocortical b-amyloid area is associated with dementia and APOE in the oldest-old. Berlau DJ, Corrada MM, Robinson JL, Geser F, Arnold SE, Lee, VM-Y, Kawas CH, Trojanowski JQ. Alzheimer’s & Dementia. 2013 Mar 6: pii: S1552-5260. PMID: 23474043.

Aging in Place in a Retirement Community: 90+ Year Olds. Paganini-Hill A. J Hous Elderly. 2013 Jan 1;27(1-2):191-205. PMID: 25288828.

APOE genotype, dementia, and mortality in the oldest-old: The 90+ Study. Corrada MM, Paganini-Hill A, Berlau DJ, Kawas CH. Alzheimer’s & Dementia. 2013 Jan 9(1):12-8. [Epub 2012 Nov 2]. PMID: 23123227.

Poor Physical Performance and Dementia in the Oldest-Old: The 90+ Study. Bullain SS, Corrada MM, Shah BA, Mozaffar FH, Panzenboeck M, Kawas CH. JAMA Neurology. 2013 Jan 7(1):107-13. PMID: 23090391.

2012

Hypertension and dementia in the elderly: the leisure world cohort study. Paganini-Hill A. Int J Hypertens. 2012;2012:205350. PMID: 22229084.

Alzheimer disease pathology and longitudinal cognitive performance in the oldest-old with no dementia. Balasubramanian AB, Kawas CH, Peltz CB et al. Neurology. 2012 Aug 28;79:915-921. PMID: 22895581.

Cognitive impairment in non-demented oldest-old: prevalence and relationship to cardiovascular risk factors. Peltz CB, Corrada MM, Berlau DJ, Kawas CH. Alzheimer’s & Dementia. 2012; 8(2):87-94. [Epub Nov 4, 2011]. PMID: 22055654. PMCID: 3276712.

A population-based clinicopathological study in the oldest-old: The 90+ Study. Corrada MM, Berlau DJ, Kawas CH. Curr Alzheimer Res. 2012;9:709-717. PMID: 22471863. PMCID: 3409303.

Disability in the Oldest-old: Incidence and Risk Factors in The 90+ Study. Berlau DJ, Corrada MM, Peltz CB, Kawas CH. Am J Geriatr Psychiatry. 2012, 20:159-168. PMID: 22273736. PMCID: 3266513.

2011

Neocortical and hippocampal amyloid-beta and tau measures associate with dementia in the oldest-old. Robinson JL, Geser F, Corrada MM, Berlau DJ, Arnold SE, Kawas CH, Lee VM, Trojanowski JQ. Brain. 134(Pt 12):3705-3712, 2011. PMID: 22120149. PMCID: 3235569.

Lifestyle practices and cardiovascular disease mortality in the elderly: the Leisure World Cohort Study. Paganini-Hill A. Cardiol Res Pract. 2011;2011:983764.

Activities and mortality in the elderly: the Leisure World Cohort Study. Paganini-Hill A, Kawas CH, Corrada MM. J Gerontol A Biol Sci Med Sci. 2011;66:559-567. PubMedCentID: 3074957.

Incidence of dementia in oldest-old with amnestic MCI and other cognitive impairments. Peltz CB, Corrada MM, Berlau DJ, Kawas CH. Neurology. 2011; 77:1906-1912. PMID: 22076544. PMCID: 3233189

Bathing as a potential target for disability reduction in the oldest old. Berlau DJ, Corrada MM, Peltz CB, Kawas CH. Am J Public Health. 2011 Feb;101:200-201.

Diagnosing dementia in the oldest-old. Brumback-Peltz C, Balasubramanian AB, Corrada MM, Kawas CH. Maturitas. 2011 Oct;70:164-168. PubMedCentID: 3171568.

2010

Being overweight in adults aged 70-75 is associated with a reduction in mortality risk compared with normal BMI. Corrada MM, Paganini-Hill A. Evid Based Med. 2010;15:126-127.

Dementia incidence continues to increase with age in the oldest-old: The 90+ Study. Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. Ann Neurol. 2010;67:114-121.

Abnormal EEGs in cognitively and physically healthy oldest old: findings from The 90+ Study. Peltz CB, Kim HL, Kawas CH. J Clin Neurophysiol. 2010;27:292-295.

2009

High levels of serum C-reactive protein are associated with greater risk of all-cause mortality, but not dementia, in the oldest-old: Results from The 90+ Study. Kravitz BA, Corrada MM, Kawas CH. J Am Geriatr Soc. 2009;57:641-646.

The prevalence of disability in the oldest-old is high and continues to increase with age: findings from The 90+ Study. Berlau DJ, Corrada MM, Kawas CH. Int J Geriatr Psychiatry. 2009;24:1217-1225.

APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Berlau DJ, Corrada MM, Head E, Kawas CH. Neurology. 2009;72:829-834.

Synaptic proteins, neuropathology and cognitive status in the oldest-old. Head E, Corrada MM, Kahle-Wrobleski K, Kim RC, Sarsoza F, Goodus M, Kawas CH. Neurobiol Aging. 2009;30:1125-1134.

Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old. Kravitz BA, Corrada MM, Kawas CH. Alzheimers Dement. 2009;5:318-323.

2008

Prevalence of dementia after age 90: results from The 90+ Study. Corrada MM, Brookmeyer R, Berlau D, Paganini-Hill A, Kawas CH. Neurology. 2008;71:337-343.

The oldest old and The 90+ Study. Kawas CH. Alzheimers Dement. 2008;4:S56-59.

2007

Sensitivity and specificity of the mini-mental state examination for identifying dementia in the oldest-old: The 90+ Study. Kahle-Wrobleski K, Corrada MM, Li B, Kawas CH. J Am Geriatr Soc. 2007;55:284-289.

Type of alcohol consumed, changes in intake over time and mortality: the Leisure World Cohort Study. Paganini-Hill A, Kawas CH, Corrada MM. Age Ageing. 2007;36:203-209.

Neuropsychological data in nondemented oldest-old: The 90+ Study. Whittle C, Corrada MM, Dick M, Ziegler R, Kahle-Wrobleski K, Paganini-Hill A, Kawas CH. J Clin Exp Neuropsychol. 2007;29:290-299.

Dissociation of neuropathologic findings and cognition: case report of an apolippoprotein E e2/e2 genotype. Berlau DJ, Kahle-Wrobleski K, Head E, M G, Kim R, Kawas CH. Arch Neurol. 2007;64:1193-1196.

Non-alcoholic beverage and caffeine consumption and mortality: the Leisure World Cohort Study. Paganini-Hill A, Kawas CH, Corrada MM. Prev Med. 2007;44:305-310.

2006

Increased longevity in older users of postmenopausal estrogen therapy: the Leisure World Cohort Study. Paganini-Hill A, Corrada MM, Kawas CH. Menopause. 2006;13:12-18.

Association of body mass index and weight change with all-cause mortality in the elderly. Corrada MM, Kawas CH, Mozaffar F, Paganini-Hill A. Am J Epidemiol. 2006;163:938-949.

Alzheimer’s and dementia in the oldest-old: a century of challenges. Kawas CH, Corrada MM. Curr Alzheimer Res. 2006;3:411-419.

2004

Computerized neuropsychiatric assessment of geriatric subjects by content analysis of brief samples of their speech. Gottschalk LA, Kawas CH, Hoang A, Bechtel RJ. Comput Inform Nurs. 2004;22:351-355.