The business of developing and selling medications is a huge industry, with companies bringing in billions in revenue every year. Globally, sales of prescription drugs are expected to hit $1.2 trillion in 2024. The most expensive medications are developed to fight rare conditions that are caused by genetic abnormalities.

This list of drugs represents the value of each drug over a month's time. Some of these medicines per dose cost are not as high as others, but the number of doses someone has to take in a month place the drug on the list. Zolgensma is unique among this list as it only requires one dose to be effective. However, at over $2 million for one dose, it is the most expensive.