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Andrew R. Bogdan, Amanda W. Dombrowski . Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry. Journal of Medicinal Chemistry 2019 , 62 (14) , 6422-6468. 62 (14) , 6422-6468. https://doi.org/10.1021/acs.jmedchem.8b01760

Anna Szelwicka, Przemysław Zawadzki, Magdalena Sitko, Sławomir Boncel, Wojciech Czardybon, Anna Chrobok . Continuous Flow Chemo-Enzymatic Baeyer–Villiger Oxidation with Superactive and Extra-Stable Enzyme/Carbon Nanotube Catalyst: An Efficient Upgrade from Batch to Flow. Organic Process Research & Development 2019 , 23 (7) , 1386-1395. 23 (7) , 1386-1395. https://doi.org/10.1021/acs.oprd.9b00132

Manuel Köckinger, Christopher A. Hone, C. Oliver Kappe . HCN on Tap: On-Demand Continuous Production of Anhydrous HCN for Organic Synthesis. Organic Letters 2019 , 21 (13) , 5326-5330. 21 (13) , 5326-5330. https://doi.org/10.1021/acs.orglett.9b01941

Cristian Rosso, Jason D. Williams, Giacomo Filippini, Maurizio Prato, C. Oliver Kappe . Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate. Organic Letters 2019 , 21 (13) , 5341-5345. 21 (13) , 5341-5345. https://doi.org/10.1021/acs.orglett.9b01992

Lei Zou, Adam S. Braegelman, Matthew J. Webber . Spatially Defined Drug Targeting by in Situ Host–Guest Chemistry in a Living Animal. ACS Central Science 2019 , 5 (6) , 1035-1043. 5 (6) , 1035-1043. https://doi.org/10.1021/acscentsci.9b00195

Lara Amini-Rentsch, Ennio Vanoli, Sylvia Richard-Bildstein, Roger Marti, Gianvito Vilé . A Novel and Efficient Continuous-Flow Route To Prepare Trifluoromethylated N-Fused Heterocycles for Drug Discovery and Pharmaceutical Manufacturing. Industrial & Engineering Chemistry Research 2019 , 58 (24) , 10164-10171. 58 (24) , 10164-10171. https://doi.org/10.1021/acs.iecr.9b01906

Lee J. Durndell, Mark A. Isaacs, Chao’en Li, Christopher M. A. Parlett, Karen Wilson, Adam F. Lee . Cascade Aerobic Selective Oxidation over Contiguous Dual-Catalyst Beds in Continuous Flow. ACS Catalysis 2019 , 9 (6) , 5345-5352. 9 (6) , 5345-5352. https://doi.org/10.1021/acscatal.9b00092

Binhong Lin, James L. Hedrick, Nathaniel H. Park, Robert M. Waymouth . Programmable High-Throughput Platform for the Rapid and Scalable Synthesis of Polyester and Polycarbonate Libraries. Journal of the American Chemical Society 2019 , 141 (22) , 8921-8927. 141 (22) , 8921-8927. https://doi.org/10.1021/jacs.9b02450

Nirmala Mohanta, Moreshwar B. Chaudhari, Naveen Kumar Digrawal, Boopathy Gnanaprakasam . Rapid and Multigram Synthesis of Vinylogous Esters under Continuous Flow: An Access to Transetherification and Reverse Reaction of Vinylogous Esters. Organic Process Research & Development 2019 , 23 (5) , 1034-1045. 23 (5) , 1034-1045. https://doi.org/10.1021/acs.oprd.9b00067

Marcus H. Reis, Travis P. Varner, Frank A. Leibfarth . The Influence of Residence Time Distribution on Continuous-Flow Polymerization. Macromolecules 2019 , 52 (9) , 3551-3557. 52 (9) , 3551-3557. https://doi.org/10.1021/acs.macromol.9b00454

Jeffrey Y. Pan . Engineering Chemistry Innovation. ACS Medicinal Chemistry Letters 2019 , 10 (5) , 703-707. 10 (5) , 703-707. https://doi.org/10.1021/acsmedchemlett.9b00096

Parthasarathy Gandeepan, Nikolaos Kaplaneris, Stefano Santoro, Luigi Vaccaro, Lutz Ackermann . Biomass-Derived Solvents for Sustainable Transition Metal-Catalyzed C–H Activation. ACS Sustainable Chemistry & Engineering 2019 , 7 (9) , 8023-8040. 7 (9) , 8023-8040. https://doi.org/10.1021/acssuschemeng.9b00226

Irini Abdiaj, Clemens R. Horn, Jesus Alcazar . Scalability of Visible-Light-Induced Nickel Negishi Reactions: A Combination of Flow Photochemistry, Use of Solid Reagents, and In-Line NMR Monitoring. The Journal of Organic Chemistry 2019 , 84 (8) , 4748-4753. 84 (8) , 4748-4753. https://doi.org/10.1021/acs.joc.8b02358

Yuta Endo, Mai Furusawa, Toshiya Shimazaki, Yusuke Takahashi, Yuichi Nakahara, Aiichiro Nagaki . Molecular Weight Distribution of Polymers Produced by Anionic Polymerization Enables Mixability Evaluation. Organic Process Research & Development 2019 , 23 (4) , 635-640. 23 (4) , 635-640. https://doi.org/10.1021/acs.oprd.8b00403

Bruno Cerra, Andrea Carotti, Daniela Passeri, Roccaldo Sardella, Giada Moroni, Alessandro Di Michele, Antonio Macchiarulo, Roberto Pellicciari, Antimo Gioiello . Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists. ACS Medicinal Chemistry Letters 2019 , 10 (4) , 677-681. 10 (4) , 677-681. https://doi.org/10.1021/acsmedchemlett.8b00459

Anna Jo Oosthoek-de Vries, Pieter J. Nieuwland, Jacob Bart, Kaspar Koch, Johannes W. G. Janssen, P. Jan M. van Bentum, Floris P. J. T. Rutjes, Han J. G. E. Gardeniers, Arno P. M. Kentgens . Inline Reaction Monitoring of Amine-Catalyzed Acetylation of Benzyl Alcohol Using a Microfluidic Stripline Nuclear Magnetic Resonance Setup. Journal of the American Chemical Society 2019 , 141 (13) , 5369-5380. 141 (13) , 5369-5380. https://doi.org/10.1021/jacs.9b00039

Yuanze Wang, Shabnam Shaabani, Maryam Ahmadianmoghaddam, Li Gao, Ruixue Xu, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Joe Olechno, Richard Ellson, Michael Kossenjans, Victoria Helan, Matthew Groves, Alexander Dömling . Acoustic Droplet Ejection Enabled Automated Reaction Scouting. ACS Central Science 2019 , 5 (3) , 451-457. 5 (3) , 451-457. https://doi.org/10.1021/acscentsci.8b00782

Antonio J. Exposito, Yang Bai, Kirill Tchabanenko, Evgeny V. Rebrov, Nikolay Cherkasov . Process Intensification of Continuous-Flow Imine Hydrogenation in Catalyst-Coated Tube Reactors. Industrial & Engineering Chemistry Research 2019 , 58 (11) , 4433-4442. 58 (11) , 4433-4442. https://doi.org/10.1021/acs.iecr.8b06058

Subhabrata Maiti, Oleg E. Shklyaev, Anna C. Balazs, Ayusman Sen . Self-Organization of Fluids in a Multienzymatic Pump System. Langmuir 2019 , 35 (10) , 3724-3732. 35 (10) , 3724-3732. https://doi.org/10.1021/acs.langmuir.8b03607

Aleksandra Jasiak, Grażyna Mielniczak, Krzysztof Owsianik, Marek Koprowski, Dorota Krasowska, Józef Drabowicz . Solvent-Free Michaelis–Arbuzov Rearrangement under Flow Conditions. The Journal of Organic Chemistry 2019 , 84 (5) , 2619-2625. 84 (5) , 2619-2625. https://doi.org/10.1021/acs.joc.8b03053

Neomy Zaquen, Ak M. N. B. P. H. A. Kadir, Afiq Iasa, Nathaniel Corrigan, Tanja Junkers, Per B. Zetterlund, Cyrille Boyer . Rapid Oxygen Tolerant Aqueous RAFT Photopolymerization in Continuous Flow Reactors. Macromolecules 2019 , 52 (4) , 1609-1619. 52 (4) , 1609-1619. https://doi.org/10.1021/acs.macromol.8b02628

Druval Santos de Sá, Rodrigo de Andrade Bustamante, Carlos Eduardo Rodrigues Rocha, Verônica Diniz da Silva, Elton Jorge da Rocha Rodrigues, Camilla Djenne Buarque Müller, Khosrow Ghavami, Alessandro Massi, Omar Ginoble Pandoli . Fabrication of Lignocellulose-Based Microreactors: Copper-Functionalized Bamboo for Continuous-Flow CuAAC Click Reactions. ACS Sustainable Chemistry & Engineering 2019 , 7 (3) , 3267-3273. 7 (3) , 3267-3273. https://doi.org/10.1021/acssuschemeng.8b05273

Kaid C. Harper, Eric G. Moschetta, Shailendra V. Bordawekar, Steven J. Wittenberger . A Laser Driven Flow Chemistry Platform for Scaling Photochemical Reactions with Visible Light. ACS Central Science 2019 , 5 (1) , 109-115. 5 (1) , 109-115. https://doi.org/10.1021/acscentsci.8b00728

Matthew P. Thompson, Itziar Peñafiel, Sebastian C. Cosgrove, Nicholas J. Turner . Biocatalysis Using Immobilized Enzymes in Continuous Flow for the Synthesis of Fine Chemicals. Organic Process Research & Development 2019 , 23 (1) , 9-18. 23 (1) , 9-18. https://doi.org/10.1021/acs.oprd.8b00305

Jason D. Williams, Momoe Nakano, Romaric Gérardy, Juan A. Rincón, Óscar de Frutos, Carlos Mateos, Jean-Christophe M. Monbaliu, C. Oliver Kappe . Finding the Perfect Match: A Combined Computational and Experimental Study toward Efficient and Scalable Photosensitized [2 + 2] Cycloadditions in Flow. Organic Process Research & Development 2019 , 23 (1) , 78-87. 23 (1) , 78-87. https://doi.org/10.1021/acs.oprd.8b00375

Anna L. Dunn, David C. Leitch, Michel Journet, Michael Martin, Elie A. Tabet, Neil R. Curtis, Glynn Williams, Charles Goss, Tony Shaw, Bernie O’Hare, Charles Wade, Matthew A. Toczko, Peng Liu . Selective Continuous Flow Iodination Guided by Direct Spectroscopic Observation of Equilibrating Aryl Lithium Regioisomers. Organometallics 2019 , 38 (1) , 129-137. 38 (1) , 129-137. https://doi.org/10.1021/acs.organomet.8b00538

Gaurav Giri, Lu Yang, Yiming Mo, Klavs F. Jensen . Adding Crystals To Minimize Clogging in Continuous Flow Synthesis. Crystal Growth & Design 2019 , 19 (1) , 98-105. 19 (1) , 98-105. https://doi.org/10.1021/acs.cgd.8b00999

Aline A. N. de Souza, Nathalia S. Silva, Andressa V. Müller, André S. Polo, Timothy J. Brocksom, Kleber T. de Oliveira . Porphyrins as Photoredox Catalysts in Csp2–H Arylations: Batch and Continuous Flow Approaches. The Journal of Organic Chemistry 2018 , 83 (24) , 15077-15086. 83 (24) , 15077-15086. https://doi.org/10.1021/acs.joc.8b02355

Yiding Chen, Marco Leonardi, Paul Dingwall, Ricardo Labes, Patrick Pasau, David C. Blakemore, Steven V. Ley . Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow. The Journal of Organic Chemistry 2018 , 83 (24) , 15558-15568. 83 (24) , 15558-15568. https://doi.org/10.1021/acs.joc.8b02721

Daniel Cortés-Borda, Eric Wimmer, Boris Gouilleux, Elvina Barré, Nicolas Oger, Lubna Goulamaly, Louis Peault, Benoît Charrier, Charlotte Truchet, Patrick Giraudeau, Mireia Rodriguez-Zubiri, Erwan Le Grognec, François-Xavier Felpin . An Autonomous Self-Optimizing Flow Reactor for the Synthesis of Natural Product Carpanone. The Journal of Organic Chemistry 2018 , 83 (23) , 14286-14299. 83 (23) , 14286-14299. https://doi.org/10.1021/acs.joc.8b01821

Johannes Schwan, Merlin Kleoff, Bence Hartmayer, Philipp Heretsch, Mathias Christmann . Synthesis of Quinolinone Alkaloids via Aryne Insertions into Unsymmetric Imides in Flow. Organic Letters 2018 , 20 (23) , 7661-7664. 20 (23) , 7661-7664. https://doi.org/10.1021/acs.orglett.8b03392

Clément Audubert, Alexanne Bouchard, Gary Mathieu, Hélène Lebel . Chemoselective Synthesis of Amines from Ammonium Hydroxide and Hydroxylamine in Continuous Flow. The Journal of Organic Chemistry 2018 , 83 (22) , 14203-14209. 83 (22) , 14203-14209. https://doi.org/10.1021/acs.joc.8b02387

Manuel Köckinger, Christopher A. Hone, Bernhard Gutmann, Paul Hanselmann, Michael Bersier, Ana Torvisco, C. Oliver Kappe . Scalable Continuous Flow Process for the Synthesis of Eflornithine Using Fluoroform as Difluoromethyl Source. Organic Process Research & Development 2018 , 22 (11) , 1553-1563. 22 (11) , 1553-1563. https://doi.org/10.1021/acs.oprd.8b00318

Ciaran P. Seath, David B. Vogt, Zihao Xu, Allyson J. Boyington, Nathan T. Jui . Radical Hydroarylation of Functionalized Olefins and Mechanistic Investigation of Photocatalytic Pyridyl Radical Reactions. Journal of the American Chemical Society 2018 , 140 (45) , 15525-15534. 140 (45) , 15525-15534. https://doi.org/10.1021/jacs.8b10238

Leiming Tian, Isaac J. Krauss . Stereoselective Homocrotylation of Aldehydes: Enantioselective Synthesis of Allylic-Substituted Z/E-Alkenes. Organic Letters 2018 , 20 (21) , 6730-6735. 20 (21) , 6730-6735. https://doi.org/10.1021/acs.orglett.8b02837

Rajat Pandey, Ramasamy Vijaya Anand . Base-Catalyzed 1,6-Conjugate Addition of Nitroalkanes to p-Quinone Methides under Continuous Flow. ACS Omega 2018 , 3 (10) , 13967-13976. 3 (10) , 13967-13976. https://doi.org/10.1021/acsomega.8b01971

Dawei Xin, Yangcheng Lu . Thermal Decomposition of Ethyl Diazoacetate in Microtube Reactor: A Kinetics Study. ACS Omega 2018 , 3 (9) , 10526-10533. 3 (9) , 10526-10533. https://doi.org/10.1021/acsomega.8b01521

Sourav Chatterjee, Sooyeon Moon, Felix Hentschel, Kerry Gilmore, Peter H. Seeberger . An Empirical Understanding of the Glycosylation Reaction. Journal of the American Chemical Society 2018 , 140 (38) , 11942-11953. 140 (38) , 11942-11953. https://doi.org/10.1021/jacs.8b04525

Tomoya Karasawa, Raphaël Oriez, Naoya Kumagai, Masakatsu Shibasaki . anti-Selective Catalytic Asymmetric Nitroaldol Reaction of α-Keto Esters: Intriguing Solvent Effect, Flow Reaction, and Synthesis of Active Pharmaceutical Ingredients. Journal of the American Chemical Society 2018 , 140 (38) , 12290-12295. 140 (38) , 12290-12295. https://doi.org/10.1021/jacs.8b08236

J. Christopher McWilliams, Ayman D. Allian, Suzanne M. Opalka, Scott A. May, Michel Journet, Timothy M. Braden . The Evolving State of Continuous Processing in Pharmaceutical API Manufacturing: A Survey of Pharmaceutical Companies and Contract Manufacturing Organizations. Organic Process Research & Development 2018 , 22 (9) , 1143-1166. 22 (9) , 1143-1166. https://doi.org/10.1021/acs.oprd.8b00160

Jennifer Koviach-Côté, Alyssa L. Pirinelli . Incorporating Carbohydrates into Laboratory Curricula. Chemical Reviews 2018 , 118 (17) , 7986-8004. 118 (17) , 7986-8004. https://doi.org/10.1021/acs.chemrev.7b00757

François Lévesque, Nicholas J. Rogus, Glenn Spencer, Plamen Grigorov, Jonathan P. McMullen, David A. Thaisrivongs, Ian W. Davies, John R. Naber . Advancing Flow Chemistry Portability: A Simplified Approach to Scaling Up Flow Chemistry. Organic Process Research & Development 2018 , 22 (8) , 1015-1021. 22 (8) , 1015-1021. https://doi.org/10.1021/acs.oprd.8b00063

Avedis Karadeolian, Dineshkumar Patel, Prabhudas Bodhuri, Gamini Weeratunga, Boris Gorin . Continuous Flow Process for Reductive Deoxygenation of ω-Chloroketone in the Synthesis of Vilazodone. Organic Process Research & Development 2018 , 22 (8) , 1022-1028. 22 (8) , 1022-1028. https://doi.org/10.1021/acs.oprd.8b00145

Nenad Micic, Anastasios Polyzos . Radical Carbonylation Mediated by Continuous-Flow Visible-Light Photocatalysis: Access to 2,3-Dihydrobenzofurans. Organic Letters 2018 , 20 (15) , 4663-4666. 20 (15) , 4663-4666. https://doi.org/10.1021/acs.orglett.8b01971

Samir Diab, Dimitrios I. Gerogiorgis . Technoeconomic Optimization of Continuous Crystallization for Three Active Pharmaceutical Ingredients: Cyclosporine, Paracetamol, and Aliskiren. Industrial & Engineering Chemistry Research 2018 , 57 (29) , 9489-9499. 57 (29) , 9489-9499. https://doi.org/10.1021/acs.iecr.8b00679

Timothy S. Chisholm, Daniel Clayton, Luke J. Dowman, Jessica Sayers, Richard J. Payne . Native Chemical Ligation–Photodesulfurization in Flow. Journal of the American Chemical Society 2018 , 140 (29) , 9020-9024. 140 (29) , 9020-9024. https://doi.org/10.1021/jacs.8b03115

Neomy Zaquen, Jonathan Yeow, Tanja Junkers, Cyrille Boyer, Per B. Zetterlund . Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors. Macromolecules 2018 , 51 (14) , 5165-5172. 51 (14) , 5165-5172. https://doi.org/10.1021/acs.macromol.8b00887

Guanshuo Shen, Takao Osako, Makoto Nagaosa, Yasuhiro Uozumi . Aqueous Asymmetric 1,4-Addition of Arylboronic Acids to Enones Catalyzed by an Amphiphilic Resin-Supported Chiral Diene Rhodium Complex under Batch and Continuous-Flow Conditions. The Journal of Organic Chemistry 2018 , 83 (14) , 7380-7387. 83 (14) , 7380-7387. https://doi.org/10.1021/acs.joc.8b00178

Bernd Nidetzky, Alexander Gutmann, Chao Zhong . Leloir Glycosyltransferases as Biocatalysts for Chemical Production. ACS Catalysis 2018 , 8 (7) , 6283-6300. 8 (7) , 6283-6300. https://doi.org/10.1021/acscatal.8b00710

Nathaniel Corrigan, Rodrigo Manahan, Ze Thong Lew, Jonathan Yeow, Jiangtao Xu, Cyrille Boyer . Copolymers with Controlled Molecular Weight Distributions and Compositional Gradients through Flow Polymerization. Macromolecules 2018 , 51 (12) , 4553-4563. 51 (12) , 4553-4563. https://doi.org/10.1021/acs.macromol.8b00673

Laurel M. Heckman, Zhi He, Timothy F. Jamison . Synthesis of Highly Substituted 2-Arylindoles via Copper-Catalyzed Coupling of Isocyanides and Arylboronic Acids. Organic Letters 2018 , 20 (11) , 3263-3267. 20 (11) , 3263-3267. https://doi.org/10.1021/acs.orglett.8b01132

Charlotte A. Clark, Darren S. Lee, Stephen J. Pickering, Martyn Poliakoff, Michael W. George . UV PhotoVap: Demonstrating How a Simple and Versatile Reactor Based on a Conventional Rotary Evaporator Can Be Used for UV Photochemistry. Organic Process Research & Development 2018 , 22 (5) , 595-599. 22 (5) , 595-599. https://doi.org/10.1021/acs.oprd.8b00037

Valentina Mancino, Bruno Cerra, Alessandro Piccinno, Antimo Gioiello . Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate, a Key Synthon for Natural Steroids and Drugs. Organic Process Research & Development 2018 , 22 (5) , 600-607. 22 (5) , 600-607. https://doi.org/10.1021/acs.oprd.8b00038

Desiree Znidar, David Cantillo, Phillip Inglesby, Alistair Boyd, C. Oliver Kappe . Process Intensification and Integration Studies for the Generation of a Key Aminoimidazole Intermediate in the Synthesis of Lanabecestat. Organic Process Research & Development 2018 , 22 (5) , 633-640. 22 (5) , 633-640. https://doi.org/10.1021/acs.oprd.8b00089

Franz J. Weiberth, Matthew R. Powers, Connor Gallin, David McDonald . Segmented Tube Reactors (STR): A Simple Tool To Screen Multiple Reactions in Parallel in Batch Mode within a Single Tube. Organic Process Research & Development 2018 , 22 (4) , 512-519. 22 (4) , 512-519. https://doi.org/10.1021/acs.oprd.8b00009

Hsiao-Wu Hsieh, Connor W. Coley, Lorenz M. Baumgartner, Klavs F. Jensen, Richard I. Robinson . Photoredox Iridium–Nickel Dual-Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor. Organic Process Research & Development 2018 , 22 (4) , 542-550. 22 (4) , 542-550. https://doi.org/10.1021/acs.oprd.8b00018

Filipa Siopa, João P. M. António, Carlos A. M. Afonso . Flow-Assisted Synthesis of Bicyclic Aziridines via Photochemical Transformation of Pyridinium Salts. Organic Process Research & Development 2018 , 22 (4) , 551-556. 22 (4) , 551-556. https://doi.org/10.1021/acs.oprd.8b00036

Behabitu Ergette Tebikachew, Karl Börjesson, Nina Kann, Kasper Moth-Poulsen . Release of Terminal Alkynes via Tandem Photodeprotection and Decarboxylation of o-Nitrobenzyl Arylpropiolates in a Flow Microchannel Reactor. Bioconjugate Chemistry 2018 , 29 (4) , 1178-1185. 29 (4) , 1178-1185. https://doi.org/10.1021/acs.bioconjchem.7b00812

Chalupat Jindakun, Sheng-Ying Hsieh, Jeffrey W. Bode . Iridium-catalyzed Synthesis of Saturated N-Heterocycles from Aldehydes and SnAP Reagents with Continuous Flow Photochemistry. Organic Letters 2018 , 20 (7) , 2071-2075. 20 (7) , 2071-2075. https://doi.org/10.1021/acs.orglett.8b00611

Alexander G. O’Brien, Eric M. Ricci, Michel Journet . Dehydration of an Insoluble Urea Byproduct Enables the Condensation of DCC and Malonic Acid in Flow. Organic Process Research & Development 2018 , 22 (3) , 399-402. 22 (3) , 399-402. https://doi.org/10.1021/acs.oprd.7b00375

Hui Li, Christopher P. Breen, Hyowon Seo, Timothy F. Jamison, Yuan-Qing Fang, and Matthew M. Bio . Ni-Catalyzed Electrochemical Decarboxylative C–C Couplings in Batch and Continuous Flow. Organic Letters 2018 , 20 (5) , 1338-1341. 20 (5) , 1338-1341. https://doi.org/10.1021/acs.orglett.8b00070

Marc Escribà-Gelonch, Timothy Noël, and Volker Hessel . Microflow High-p,T Intensification of Vitamin D3 Synthesis Using an Ultraviolet Lamp. Organic Process Research & Development 2018 , 22 (2) , 147-155. 22 (2) , 147-155. https://doi.org/10.1021/acs.oprd.7b00318

Kevin D. Raynor, Gregory D. May, Upul K. Bandarage, and Michael J. Boyd . Generation of Diversity Sets with High sp3 Fraction Using the Photoredox Coupling of Organotrifluoroborates and Organosilicates with Heteroaryl/Aryl Bromides in Continuous Flow. The Journal of Organic Chemistry 2018 , 83 (3) , 1551-1557. 83 (3) , 1551-1557. https://doi.org/10.1021/acs.joc.7b02680

David L. Hughes . Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature. Organic Process Research & Development 2018 , 22 (1) , 13-20. 22 (1) , 13-20. https://doi.org/10.1021/acs.oprd.7b00363

Jun Zhang, Yun Hu, Haiyu Wang, Aixin Guo, Jianshe Kong, Rujian Ma, Tao Wu, Yi Wang, Lian-Sheng Li, Wanping Mai, Pingda Ren, and Xiaohu Deng . Regioselective Functionalization of 4-Methyl-1H-indole for Scalable Synthesis of 2-Cyano-5-formyl-4-methyl-1H-indole. Organic Process Research & Development 2018 , 22 (1) , 97-102. 22 (1) , 97-102. https://doi.org/10.1021/acs.oprd.7b00370

Zhenpeng Zhou, Xiaocheng Li, and Richard N. Zare . Optimizing Chemical Reactions with Deep Reinforcement Learning. ACS Central Science 2017 , 3 (12) , 1337-1344. 3 (12) , 1337-1344. https://doi.org/10.1021/acscentsci.7b00492

Marcus Baumann, Ian R. Baxendale, Paolo Filipponi, and Te Hu . Sustainable Flow Synthesis of a Versatile Cyclopentenone Building Block. Organic Process Research & Development 2017 , 21 (12) , 2052-2059. 21 (12) , 2052-2059. https://doi.org/10.1021/acs.oprd.7b00328

Zhenghui Wen, Fengjun Jiao, Mei Yang, Shuainan Zhao, Feng Zhou, and Guangwen Chen . Process Development and Scale-up of the Continuous Flow Nitration of Trifluoromethoxybenzene. Organic Process Research & Development 2017 , 21 (11) , 1843-1850. 21 (11) , 1843-1850. https://doi.org/10.1021/acs.oprd.7b00291

Seth B. Herzon , Christopher D. Vanderwal . Introduction: Natural Product Synthesis. Chemical Reviews 2017 , 117 (18) , 11649-11650. 117 (18) , 11649-11650. https://doi.org/10.1021/acs.chemrev.7b00520

Robert B. Grubbs and Robert H. Grubbs . 50th Anniversary Perspective: Living Polymerization—Emphasizing the Molecule in Macromolecules. Macromolecules 2017 , 50 (18) , 6979-6997. 50 (18) , 6979-6997. https://doi.org/10.1021/acs.macromol.7b01440

Daniele Ragno, Graziano Di Carmine, Arianna Brandolese, Olga Bortolini, Pier Paolo Giovannini, and Alessandro Massi . Immobilization of Privileged Triazolium Carbene Catalyst for Batch and Flow Stereoselective Umpolung Processes. ACS Catalysis 2017 , 7 (9) , 6365-6375. 7 (9) , 6365-6375. https://doi.org/10.1021/acscatal.7b02164

Valerio Isoni, Ken Mendoza, Eleen Lim, and Soo Khean Teoh . Screwing NaBH4 through a Barrel without a Bang: A Kneaded Alternative to Fed-Batch Carbonyl Reductions. Organic Process Research & Development 2017 , 21 (7) , 992-1002. 21 (7) , 992-1002. https://doi.org/10.1021/acs.oprd.7b00107

Yuesu Chen, Christopher A. Hone, Bernhard Gutmann, and C. Oliver Kappe . Continuous Flow Synthesis of Carbonylated Heterocycles via Pd-Catalyzed Oxidative Carbonylation Using CO and O2 at Elevated Temperatures and Pressures. Organic Process Research & Development 2017 , 21 (7) , 1080-1087. 21 (7) , 1080-1087. https://doi.org/10.1021/acs.oprd.7b00217

Yanyan Liu, Qiankun Zhao, Jun Yue, Chaoqun Yao, Guangwen Chen. Effect of mixing on mass transfer characterization in continuous slugs and dispersed droplets in biphasic slug flow microreactors. Chemical Engineering Journal 2021 , 406 , 126885. 406 , 126885. https://doi.org/10.1016/j.cej.2020.126885

Stefano Mazzanti, Bogdan Kurpil, Bartholomäus Pieber, Markus Antonietti, Aleksandr Savateev. Dichloromethylation of enones by carbon nitride photocatalysis. Nature Communications 2020 , 11 (1) 11 (1) https://doi.org/10.1038/s41467-020-15131-0

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Saira Mumtaz, Mark J. Robertson, Michael Oelgemöller. Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones. Molecules 2019 , 24 (24) , 4527. 24 (24) , 4527. https://doi.org/10.3390/molecules24244527

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