Smit E.

Crespo C.J.

Michael Y.

et al. The effect of vitamin D and frailty on mortality among non-institutionalized US older adults. Eur J Clin Nutr. 66 : 1024-1028 View in Article Scopus (5)

PubMed

Crossref

Google Scholar

Holick M.F. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 80 ( ) View in Article Google Scholar

Holick M.F.

MacLaughlin J.A.

Clark M.B.

et al. Photosynthesis of previtamin D 3 in human skin and the physiologic consequences. Science. 210 : 203-205 View in Article PubMed

Crossref

Google Scholar

Webb A.R.

Kline L.

Holick M.F. Influence of season and latitude on the cutaneous synthesis of vitamin D 3 : exposure to winter sunlight in Boston and Edmonton will not promote vitamin D 3 synthesis in human skin. J Clin Endocrinol Metab. 67 : 373-378 View in Article PubMed

Crossref

Google Scholar

Shimada T.

Kakitani M.

Yamazaki Y.

et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 113 : 561-568 View in Article PubMed

Google Scholar

Nair R.

Maseeh A. Vitamin D: the “sunshine” vitamin. J Pharmacol Pharmacother. 3 : 118-126 View in Article PubMed

Google Scholar

Hossein-nezhad A.

Spira A.

Holick M.F. Influence of vitamin D status and vitamin D 3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS One. 8 : e58725 View in Article Scopus (3)

PubMed

Crossref

Google Scholar

Kitazawa S.

Kajimoto K.

Kondo T.

Kitazawa R. Vitamin D 3 supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter. J Cell Biochem. 89 : 771-777 View in Article Scopus (62)

PubMed

Crossref

Google Scholar

Cui X.

Pelekanos M.

Liu P.Y.

Burne T.H.

McGrath J.J.

Eyles D.W. The vitamin D receptor in dopamine neurons; its presence in human substantia nigra and its ontogenesis in rat midbrain. Neuroscience. 236 : 77-87 View in Article Scopus (5)

PubMed

Crossref

Google Scholar

Nowak R.

Szota J.

Mazurek U. Vitamin D receptor gene (VDR) transcripts in bone, cartilage, muscles and blood and microarray analysis of vitamin D responsive genes expression in paravertebral muscles of juvenile and adolescent idiopathic scoliosis patients. BMC Musculoskelet Disord. 13 : 259 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Doig C.L.

Singh P.K.

Dhiman V.K.

et al. Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns. Carcinogenesis. 34 : 248-256 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Alimirah F.

Peng X.

Yuan L.

et al. Crosstalk between the peroxisome proliferator-activated receptor γ (PPARγ) and the vitamin D receptor (VDR) in human breast cancer cells: PPARγ binds to VDR and inhibits 1α,25-dihydroxyvitamin D 3 mediated transactivation. Exp Cell Res. 318 : 2490-2497 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Nagy L.

Szanto A.

Szatmari I.

Szeles L. Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response. Physiol Rev. 92 : 739-789 View in Article Scopus (16)

PubMed

Crossref

Google Scholar

Zella L.A.

Shevde N.K.

Hollis B.W.

Cooke N.E.

Pike J.W. Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D 3 but does not directly modulate the bioactive levels of the hormone in vivo. Endocrinology. 149 : 3656-3667 View in Article Scopus (34)

PubMed

Crossref

Google Scholar

Weisser J.

Riemer S.

Schmidl M.

et al. Four distinct chondrocyte populations in the fetal bovine growth plate: highest expression levels of PTH/PTHrP receptor, Indian hedgehog, and MMP-13 in hypertrophic chondrocytes and their suppression by PTH (1-34) and PTHrP (1-40). Exp Cell Res. 279 : 1-13 View in Article Scopus (26)

PubMed

Crossref

Google Scholar

Mahadevan S.

Kumaravel V.

Bharath R. Calcium and bone disorders in pregnancy. Indian J Endocrinol Metab. 16 : 358-363 View in Article PubMed

Crossref

Google Scholar

Kovacs C.S. Vitamin D in pregnancy and lactation: maternal, fetal, and neonatal outcomes from human and animal studies. Am J Clin Nutr. 88 : 520S-528S View in Article PubMed

Google Scholar

Moller U.K.

Streym S.

Mosekilde L.

et al. Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum: a controlled cohort study. Osteoporos Int. 24 : 1307-1320 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Jones G.

Kano K.

Yamada S.

Furusawa T.

Takayama H.

Suda T. Identification of 24,25,26,27-tetranor-23-hydroxyvitamin D 3 as a product of the renal metabolism of 24,25-dihydroxyvitamin D 3 . Biochemistry. 23 : 3749-3754 View in Article PubMed

Crossref

Google Scholar

Papapetrou P.D. The interrelationship of serum 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D in pregnancy at term: a meta-analysis. Hormones. 9 : 136-144 View in Article PubMed

Google Scholar

Novakovic B.

Sibson M.

Ng H.K.

et al. Placenta-specific methylation of the vitamin D 24-hydroxylase gene: implications for feedback autoregulation of active vitamin D levels at the fetomaternal interface. J Biol Chem. 284 : 14838-14848 View in Article Scopus (83)

PubMed

Crossref

Google Scholar

Kim B.G.

Chang S.K.

Kim S.M.

Hwang J.S.

Jung J.W. Dilated cardiomyopathy in a 2 month-old infant: a severe form of hypocalcemia with vitamin D deficient rickets. Korean Circ J. 40 : 201-203 View in Article Scopus (5)

PubMed

Crossref

Google Scholar

Ma R.

Gu Y.

Zhao S.

Sun J.

Groome L.J.

Wang Y. Expressions of vitamin D metabolic components VDBP, CYP2R1, CYP27B1, CYP24A1, and VDR in placentas from normal and preeclamptic pregnancies. Am J Physiol Endocrinol Metab. 303 : E928-E935 View in Article Scopus (4)

PubMed

Crossref

Google Scholar

Maka N.

Makrakis J.

Parkington H.C.

Tare M.

Morley R.

Black M.J. Vitamin D deficiency during pregnancy and lactation stimulates nephrogenesis in rat offspring. Pediatr Nephrol. 23 : 55-61 View in Article Scopus (16)

PubMed

Crossref

Google Scholar

Stefanska B.

Karlic H.

Varga F.

Fabianowska-Majewska K.

Haslberger A. Epigenetic mechanisms in anti-cancer actions of bioactive food components: the implications in cancer prevention. Br J Pharmacol. 167 : 279-297 View in Article Scopus (13)

PubMed

Crossref

Google Scholar

Bischoff-Ferrari H.A.

Giovannucci E.

Willett W.C.

Dietrich T.

Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr. 84 : 18-28 View in Article PubMed

Google Scholar

Ross A.C.

Manson J.E.

Abrams S.A.

et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab. 96 : 53-58 View in Article Scopus (509)

PubMed

Crossref

Google Scholar

Nowson C.A.

McGrath J.J.

Ebeling P.R.

et al. Vitamin D and health in adults in Australia and New Zealand: a position statement. Med J Aust. 196 : 686-687 View in Article Scopus (9)

PubMed

Crossref

Google Scholar

Bischoff-Ferrari H.A.

Dietrich T.

Orav E.J.

et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥60 y. Am J Clin Nutr. 80 : 752-758 View in Article PubMed

Google Scholar

Muir S.W.

Montero-Odasso M. Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc. 59 : 2291-2300 View in Article Scopus (23)

PubMed

Crossref

Google Scholar

Pfeifer M.

Begerow B.

Minne H.W.

Suppan K.

Fahrleitner-Pammer A.

Dobnig H. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 20 : 315-322 View in Article Scopus (129)

PubMed

Crossref

Google Scholar

Goswami R.

Vatsa M.

Sreenivas V.

et al. Skeletal muscle strength in young Asian Indian females after vitamin D and calcium supplementation: a double-blind randomized controlled clinical trial. J Clin Endocrinol Metab. 97 : 4709-4716 View in Article Scopus (3)

PubMed

Crossref

Google Scholar

Abrahamsen B.

Masud T.

Avenell A.

et al. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ. 12 : b5463 View in Article Google Scholar

Elders P.J.

Lips P.

Netelenbos J.C.

et al. Long-term effect of calcium supplementation on bone loss in perimenopausal women. J Bone Miner Res. 9 : 963-970 View in Article PubMed

Crossref

Google Scholar

Priemel M.

von Domarus C.

Klatte T.O.

et al. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res. 25 : 305-312 View in Article Scopus (123)

PubMed

Crossref

Google Scholar

Bergman G.J.

Fan T.

McFetridge J.T.

Sen S.S. Efficacy of vitamin D 3 supplementation in preventing fractures in elderly women: a meta-analysis. Curr Med Res Opin. 26 : 1193-1201 View in Article Scopus (20)

PubMed

Crossref

Google Scholar

Bischoff-Ferrari H.A.

Willett W.C.

Wong J.B.

et al. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med. 169 : 551-561 View in Article Scopus (324)

PubMed

Crossref

Google Scholar

Avenell A.

Gillespie W.J.

Gillespie L.D.

O'Connell D. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev. : CD000227 View in Article PubMed

Google Scholar

Moyer V.A.

U.S. Preventive Services Task Force Vitamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 158 : 691-696 View in Article PubMed

Google Scholar

Bolland M.J.

Grey A.

Gamble G.D.

Reid I.R. Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women's Health Initiative (WHI) limited access data set. Am J Clin Nutr. 94 : 1144-1149 View in Article Scopus (63)

PubMed

Crossref

Google Scholar

Winzenberg T.

Powell S.

Shaw K.A.

Jones G. Effects of vitamin D supplementation on bone density in healthy children: systematic review and meta-analysis. BMJ. 342 : c7254 View in Article Scopus (39)

PubMed

Crossref

Google Scholar

Rizzoli R.

Boonen S.

Brandi M.L.

et al. Vitamin D supplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Curr Med Res Opin. 29 : 305-313 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Thorne-Lyman A.

Fawzi W.W. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 1 : 75-90 View in Article Scopus (14)

Crossref

Google Scholar

De-Regil L.M.

Palacios C.

Ansary A.

Kulier R.

Pena-Rosas J.P. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. : CD008873 View in Article PubMed

Google Scholar

Lai J.K.

Lucas R.M.

Clements M.S.

Roddam A.W.

Banks E. Hip fracture risk in relation to vitamin D supplementation and serum 25-hydroxyvitamin D levels: a systematic review and meta-analysis of randomised controlled trials and observational studies. BMC Public Health. 10 : 1471-2458 View in Article Google Scholar

Jackson C.

Gaugris S.

Sen S.S.

Hosking D. The effect of cholecalciferol (vitamin D 3 ) on the risk of fall and fracture: a meta-analysis. QJM. 100 : 185-192 View in Article Scopus (66)

PubMed

Crossref

Google Scholar

Boonen S.

Lips P.

Bouillon R.

Bischoff-Ferrari H.A.

Vanderschueren D.

Haentjens P. Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab. 92 : 1415-1423 View in Article Scopus (246)

PubMed

Crossref

Google Scholar

Avenell A.

Gillespie W.J.

Gillespie L.D.

O'Connell D.L. Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev. : CD000227 View in Article PubMed

Google Scholar

Kalyani R.R.

Stein B.

Valiyil R.

Manno R.

Maynard J.W.

Crews D.C. Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. J Am Geriatr Soc. 58 : 1299-1310 View in Article Scopus (59)

PubMed

Crossref

Google Scholar

Chung M.

Lee J.

Terasawa T.

Lau J.

Trikalinos T.A. Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med. 155 : 827-838 View in Article PubMed

Crossref

Google Scholar

Buttigliero C.

Monagheddu C.

Petroni P.

et al. Prognostic role of vitamin D status and efficacy of vitamin D supplementation in cancer patients: a systematic review. Oncologist. 16 : 1215-1227 View in Article Scopus (18)

PubMed

Crossref

Google Scholar

Bjelakovic G.

Gluud L.L.

Nikolova D.

et al. Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. : CD007470 View in Article PubMed

Google Scholar

Irlam J.H.

Visser M.M.

Rollins N.N.

Siegfried N. Micronutrient supplementation in children and adults with HIV infection. Cochrane Database Syst Rev. : CD003650 View in Article PubMed

Google Scholar

Tripkovic L.

Lambert H.

Hart K.

et al. Comparison of vitamin D 2 and vitamin D 3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 95 : 1357-1364 View in Article Scopus (24)

PubMed

Crossref

Google Scholar

Kandula P.

Dobre M.

Schold J.D.

Schreiber Jr., M.J.

Mehrotra R.

Navaneethan S.D. Vitamin D supplementation in chronic kidney disease: a systematic review and meta-analysis of observational studies and randomized controlled trials. Clin J Am Soc Nephrol. 6 : 50-62 View in Article Scopus (56)

PubMed

Crossref

Google Scholar

George P.S.

Pearson E.R.

Witham M.D. Effect of vitamin D supplementation on glycaemic control and insulin resistance: a systematic review and meta-analysis. Diabet Med. 29 : e142-e150 View in Article Scopus (17)

PubMed

Crossref

Google Scholar

Bath-Hextall F.J.

Jenkinson C.

Humphreys R.

Williams H.C. Dietary supplements for established atopic eczema. Cochrane Database Syst Rev. : CD005205 View in Article PubMed

Google Scholar

Wang L.

Manson J.E.

Song Y.

Sesso H.D. Systematic review: vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med. 152 : 315-323 View in Article PubMed

Crossref

Google Scholar

Pittas A.G.

Chung M.

Trikalinos T.

et al. Systematic review: vitamin D and cardiometabolic outcomes. Ann Intern Med. 152 : 307-314 View in Article PubMed

Crossref

Google Scholar

Ferguson J.H.

Chang A.B. Vitamin D supplementation for cystic fibrosis. Cochrane Database Syst Rev. : CD007398 View in Article Google Scholar

Abba K.

Sudarsanam T.D.

Grobler L.

Volmink J. Nutritional supplements for people being treated for active tuberculosis. Cochrane Database Syst Rev. : CD006086 View in Article PubMed

Google Scholar

Harris D.M.

Go V.L. Vitamin D and colon carcinogenesis. J Nutr. 134 : 3463S-3471S View in Article PubMed

Google Scholar

Shui I.M.

Mucci L.A.

Kraft P.

et al. Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study. J Natl Cancer Inst. 104 : 690-699 View in Article Scopus (22)

PubMed

Crossref

Google Scholar

Giangreco A.A.

Nonn L. The sum of many small changes: microRNAs are specifically and potentially globally altered by vitamin D(3) metabolites. J Steroid Biochem Mol Biol. ( ) View in Article PubMed

Google Scholar

Lee J.E.

Li H.

Chan A.T.

et al. Circulating levels of vitamin D and colon and rectal cancer: the Physicians' Health Study and a meta-analysis of prospective studies. Cancer Prev Res. 4 : 735-743 View in Article Scopus (31)

PubMed

Crossref

Google Scholar

Grant W.B. Geographic variation of prostate cancer mortality rates in the United States: implications for prostate cancer risk related to vitamin D. Int J Cancer. 111 : 470-471 View in Article Scopus (21)

PubMed

Crossref

Google Scholar

Durup D.

Jorgensen H.L.

Christensen J.

Schwarz P.

Heegaard A.M.

Lind B. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study. J Clin Endocrinol Metab. 97 : 2644-2652 View in Article Scopus (26)

PubMed

Crossref

Google Scholar

Vieth R. Enzyme kinetics hypothesis to explain the U-shaped risk curve for prostate cancer vs. 25-hydroxyvitamin D in Nordic countries. Int J Cancer. 111 : 468 View in Article Scopus (18)

PubMed

Crossref

Google Scholar

Lappe J.M.

Travers-Gustafson D.

Davies K.M.

Recker R.R.

Heaney R.P. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 85 : 1586-1591 View in Article PubMed

Google Scholar

Skinner H.G.

Michaud D.S.

Giovannucci E.

Willett W.C.

Colditz G.A.

Fuchs C.S. Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev. 15 : 1688-1695 View in Article Scopus (80)

PubMed

Crossref

Google Scholar

Stolzenberg-Solomon R.Z.

Hayes R.B.

Horst R.L.

Anderson K.E.

Hollis B.W.

Silverman D.T. Serum vitamin D and risk of pancreatic cancer in the Prostate, Lung, Colorectal, and Ovarian Screening Trial. Cancer Res. 69 : 1439-1447 View in Article Scopus (38)

PubMed

Crossref

Google Scholar

Grant W.B. An estimate of the global reduction in mortality rates through doubling vitamin D levels. Eur J Clin Nutr. 65 : 1016-1026 View in Article Scopus (33)

PubMed

Crossref

Google Scholar

Grant W.B. Lower vitamin-D production from solar ultraviolet-B irradiance may explain some differences in cancer survival rates. J Natl Med Assoc. 98 : 357-364 View in Article PubMed

Google Scholar

Grant W.B. Ecological studies of the UV-B-vitamin D-cancer hypothesis. Anticancer Res. 32 : 223-236 View in Article PubMed

Google Scholar

Luxwolda M.F.

Kuipers R.S.

Kema I.P.

Dijck-Brouwer D.A.

Muskiet F.A. Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l. Br J Nutr. 108 : 1557-1561 View in Article Scopus (22)

PubMed

Crossref

Google Scholar

Zittermann A.

Iodice S.

Pilz S.

Grant W.B.

Bagnardi V.

Gandini S. Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr. 95 : 91-100 View in Article Scopus (70)

PubMed

Crossref

Google Scholar

Ma Y.

Zhang P.

Wang F.

Yang J.

Liu Z.

Qin H. Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol. 29 : 3775-3782 View in Article Scopus (45)

PubMed

Crossref

Google Scholar

Pilz S.

Iodice S.

Zittermann A.

Grant W.B.

Gandini S. Vitamin D status and mortality risk in CKD: a meta-analysis of prospective studies. Am J Kidney Dis. 58 : 374-382 View in Article PubMed

Google Scholar

Rejnmark L.

Avenell A.

Masud T.

et al. Vitamin D with calcium reduces mortality: patient level pooled analysis of 70,528 patients from eight major vitamin D trials. J Clin Endocrinol Metab. 97 : 2670-2681 View in Article Scopus (25)

PubMed

Crossref

Google Scholar

Thomas G.N.

ó Hartaigh B.

Bosch J.A.

et al. Vitamin D levels predict all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. Diabetes Care. 35 : 1158-1164 View in Article Scopus (18)

PubMed

Crossref

Google Scholar

Doherty T.M.

Tang W.

Dascalos S.

et al. Ethnic origin and serum levels of 1α,25-dihydroxyvitamin D 3 are independent predictors of coronary calcium mass measured by electron-beam computed tomography. Circulation. 96 : 1477-1481 View in Article PubMed

Crossref

Google Scholar

Watson K.E.

Abrolat M.L.

Malone L.L.

et al. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation. 96 : 1755-1760 View in Article PubMed

Crossref

Google Scholar

Cigolini M.

Iagulli M.P.

Miconi V.

Galiotto M.

Lombardi S.

Targher G. Serum 25-hydroxyvitamin D 3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients. Diabetes Care. 29 : 722-724 View in Article PubMed

Crossref

Google Scholar

Arnson Y, Itzhaky D, Mosseri M, et al. Vitamin D inflammatory cytokines and coronary events: a comprehensive review [published online January 12, 2013]. Clin Rev Allergy Immunol. https://doi.org/10.1007/s12016-013-8356-0. View in Article Google Scholar

Grundmann M.

Haidar M.

Placzko S.

et al. Vitamin D improves the angiogenic properties of endothelial progenitor cells. Am J Physiol Cell Physiol. 303 : 29 View in Article Scopus (8)

Crossref

Google Scholar

Dong Y.

Stallmann-Jorgensen I.S.

Pollock N.K.

et al. A 16-week randomized clinical trial of 2000 international units daily vitamin D 3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness. J Clin Endocrinol Metab. 95 : 4584-4591 View in Article Scopus (63)

PubMed

Crossref

Google Scholar

Forouhi N.G.

Ye Z.

Rickard A.P.

et al. Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies. Diabetologia. 55 : 2173-2182 View in Article Scopus (19)

PubMed

Crossref

Google Scholar

Welsh P.

Doolin O.

McConnachie A.

et al. Circulating 25OHD, dietary vitamin D, PTH, and calcium associations with incident cardiovascular disease and mortality: the MIDSPAN Family Study. J Clin Endocrinol Metab. 97 : 4578-4587 View in Article Scopus (5)

PubMed

Crossref

Google Scholar

Agmon-Levin N, Theodor E, Segal RM, Shoenfeld Y. Vitamin D in systemic and organ-specific autoimmune diseases [published online December 14, 2012]. Clin Rev Allergy Immunol. https://doi.org/10.1007/s12016-012-8342-y. View in Article Google Scholar

Higgins MJ, Mackie SL, Thalayasingam N, Bingham SJ, Hamilton J, Kelly CA. The effect of vitamin D levels on the assessment of disease activity in rheumatoid arthritis [published online January 23, 2013]. Clin Rheumatol. https://doi.org/10.1007/s10067-013-2174-x. View in Article Google Scholar

Szekely J.I.

Pataki A. Effects of vitamin D on immune disorders with special regard to asthma, COPD and autoimmune diseases: a short review. Expert Rev Respir Med. 6 : 683-704 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Cantorna M.T.

Mahon B.D. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med. 229 : 1136-1142 View in Article Google Scholar

Villaggio B.

Soldano S.

Cutolo M. 1,25-dihydroxyvitamin D 3 downregulates aromatase expression and inflammatory cytokines in human macrophages. Clin Exp Rheumatol. 30 : 934-938 View in Article PubMed

Google Scholar

Merlino L.A.

Curtis J.

Mikuls T.R.

Cerhan J.R.

Criswell L.A.

Saag K.G. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum. 50 : 72-77 View in Article Scopus (337)

PubMed

Crossref

Google Scholar

Andjelkovic Z.

Vojinovic J.

Pejnovic N.

et al. Disease modifying and immunomodulatory effects of high dose 1 α (OH) D3 in rheumatoid arthritis patients. Clin Exp Rheumatol. 17 : 453-456 View in Article PubMed

Google Scholar

Sen D.

Ranganathan P. Vitamin D in rheumatoid arthritis: panacea or placebo?. Discov Med. 14 : 311-319 View in Article PubMed

Google Scholar

Haga H.J.

Schmedes A.

Naderi Y.

Moreno A.M.

Peen E. Severe deficiency of 25-hydroxyvitamin D 3 (25-OH-D 3 ) is associated with high disease activity of rheumatoid arthritis. Clin Rheumatol. 15 : 15 View in Article Google Scholar

Schwalfenberg G.K. Solar radiation and vitamin D: mitigating environmental factors in autoimmune disease. J Environ Public Health. 2012 : 619381 View in Article PubMed

Google Scholar

Stene L.C.

Ulriksen J.

Magnus P.

Joner G. Use of cod liver oil during pregnancy associated with lower risk of type I diabetes in the offspring. Diabetologia. 43 : 1093-1098 View in Article Scopus (187)

PubMed

Crossref

Google Scholar

Rajakumar K.

de las Heras J.

Lee S.

Holick M.F.

Arslanian S.A. 25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth. Diabetes Care. 35 : 627-633 View in Article Scopus (9)

PubMed

Crossref

Google Scholar

Munger K.L.

Zhang S.M.

O'Reilly E.

et al. Vitamin D intake and incidence of multiple sclerosis. Neurology. 62 : 60-65 View in Article PubMed

Crossref

Google Scholar

Runia T.F.

Hop W.C.

de Rijke Y.B.

Buljevac D.

Hintzen R.Q. Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology. 79 : 261-266 View in Article Scopus (15)

PubMed

Crossref

Google Scholar

Kimball S.M.

Ursell M.R.

O'Connor P.

Vieth R. Safety of vitamin D 3 in adults with multiple sclerosis. Am J Clin Nutr. 86 : 645-651 View in Article PubMed

Google Scholar

Sabetta J.R.

DePetrillo P.

Cipriani R.J.

Smardin J.

Burns L.A.

Landry M.L. Serum 25-hydroxyvitamin D and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One. 5 : 0011088 View in Article Scopus (75)

Crossref

Google Scholar

Urashima M.

Segawa T.

Okazaki M.

Kurihara M.

Wada Y.

Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 91 : 1255-1260 View in Article Scopus (199)

PubMed

Crossref

Google Scholar

Tolppanen A.M.

Williams D.

Henderson J.

Lawlor D.A. Serum 25-hydroxy-vitamin D and ionised calcium in relation to lung function and allergen skin tests. Eur J Clin Nutr. 65 : 493-500 View in Article Scopus (9)

PubMed

Crossref

Google Scholar

Rochat M.K.

Ege M.J.

Plabst D.

et al. Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood. Clin Exp Allergy. 40 : 786-794 View in Article Scopus (20)

PubMed

Crossref

Google Scholar

Eyles D.W.

Burne T.H.

McGrath J.J. Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol. 34 : 47-64 View in Article Scopus (9)

PubMed

Crossref

Google Scholar

Bartoccini E.

Marini F.

Damaskopoulou E.

et al. Nuclear lipid microdomains regulate nuclear vitamin D 3 uptake and influence embryonic hippocampal cell differentiation. Mol Biol Cell. 22 : 3022-3031 View in Article Scopus (3)

PubMed

Crossref

Google Scholar

Becker A.

Eyles D.W.

McGrath J.J.

Grecksch G. Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behav Brain Res. 161 : 306-312 View in Article Scopus (78)

PubMed

Crossref

Google Scholar

Yu J.

Gattoni-Celli M.

Zhu H.

et al. Vitamin D 3 -enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice. J Alzheimers Dis. 25 : 295-307 View in Article PubMed

Google Scholar

Groves N.J.

Kesby J.P.

Eyles D.W.

McGrath J.J.

Mackay-Sim A.

Burne T.H. Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice. Behav Brain Res. 241 : 120-131 View in Article Scopus (3)

PubMed

Crossref

Google Scholar

Maddock J.

Berry D.J.

Geoffroy M.C.

Power C.

Hypponen E. Vitamin D and common mental disorders in mid-life: cross-sectional and prospective findings. Clin Nutr. 21 : 00030-00037 View in Article Google Scholar

Hoogendijk W.J.

Lips P.

Dik M.G.

Deeg D.J.

Beekman A.T.

Penninx B.W. Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults. Arch Gen Psychiatry. 65 : 508-512 View in Article Scopus (120)

PubMed

Crossref

Google Scholar

Armstrong D.J.

Meenagh G.K.

Bickle I.

Lee A.S.

Curran E.S.

Finch M.B. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. 26 : 551-554 View in Article Scopus (65)

PubMed

Crossref

Google Scholar

Jorde R.

Waterloo K.

Saleh F.

Haug E.

Svartberg J. Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels: the Tromso study. J Neurol. 253 : 464-470 View in Article Scopus (80)

PubMed

Crossref

Google Scholar

Gloth III, F.M.

Alam W.

Hollis B. Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder. J Nutr Health Aging. 3 : 5-7 View in Article PubMed

Google Scholar

Wei S.Q.

Qi H.P.

Luo Z.C.

Fraser W.D. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med. 26 : 889-899 View in Article Scopus (6)

PubMed

Crossref

Google Scholar

Hollis B.W.

Horst R.L. The assessment of circulating 25(OH)D and 1,25(OH)2D: where we are and where we are going. J Steroid Biochem Mol Biol. 103 : 473-476 View in Article Scopus (45)

PubMed

Crossref

Google Scholar

Schottker B.

Jansen E.H.

Haug U.

Schomburg L.

Kohrle J.

Brenner H. Standardization of misleading immunoassay based 25-hydroxyvitamin D levels with liquid chromatography tandem-mass spectrometry in a large cohort study. PLoS One. 7 : e48774 View in Article Scopus (5)

PubMed

Crossref

Google Scholar

Binkley N.

Krueger D.

Cowgill C.S.

et al. Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab. 89 : 3152-3157 View in Article Scopus (324)

PubMed

Crossref

Google Scholar

Carter G.D.

Carter R.

Jones J.

Berry J. How accurate are assays for 25-hydroxyvitamin D? data from the international vitamin D external quality assessment scheme. Clin Chem. 50 : 2195-2197 View in Article Scopus (169)

PubMed

Crossref

Google Scholar

Singh R.J.

Taylor R.L.

Reddy G.S.

Grebe S.K. C-3 epimers can account for a significant proportion of total circulating 25-hydroxyvitamin D in infants, complicating accurate measurement and interpretation of vitamin D status. J Clin Endocrinol Metab. 91 : 3055-3061 View in Article Scopus (142)

PubMed

Crossref

Google Scholar

Looker A.C.

Johnson C.L.

Lacher D.A.

Pfeiffer C.M.

Schleicher R.L.

Sempos C.T. Vitamin D status: United States, 2001-2006. NCHS Data Brief. 59 : 1-8 View in Article PubMed

Google Scholar

Centers for Disease Control and Prevention (CDC). Centers for Danalytical note for NHANES 2000-2006 and NHANES III (1988-1994) 25-hydroxyvitamin D analysis. http://www.cdc.gov/nchs/data/nhanes/nhanes3/VitaminD_analyticnote.pdf. Revised November 2010. Accessed June 6, 2013. View in Article Google Scholar

Sempos C.T.

Vesper H.W.

Phinney K.W.

Thienpont L.M.

Coates P.M. Vitamin D status as an international issue: national surveys and the problem of standardization. Scand J Clin Lab Invest Suppl. 243 : 32-40 View in Article PubMed

Google Scholar

Glendenning P.

Taranto M.

Noble J.M.

et al. Current assays overestimate 25-hydroxyvitamin D 3 and underestimate 25-hydroxyvitamin D 2 compared with HPLC: need for assay-specific decision limits and metabolite-specific assays. Ann Clin Biochem. 43 : 23-30 View in Article Scopus (79)

PubMed

Crossref

Google Scholar

Shivane V.K.

Sarathi V.

Bandgar T.

Menon P.

Shah N.S. High prevalence of hypovitaminosis D in young healthy adults from the western part of India. Postgrad Med J. 87 : 514-518 View in Article Scopus (8)

PubMed

Crossref

Google Scholar

Ganji V.

Zhang X.

Tangpricha V. Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assay-adjusted data. J Nutr. 142 : 498-507 View in Article Scopus (16)

PubMed

Crossref

Google Scholar

Gonzalez-Gross M.

Valtuena J.

Breidenassel C.

et al. Vitamin D status among adolescents in Europe: the Healthy Lifestyle in Europe by Nutrition in Adolescence study. Br J Nutr. 107 : 755-764 View in Article Scopus (14)

PubMed

Crossref

Google Scholar

Daly R.M.

Gagnon C.

Lu Z.X.

et al. Prevalence of vitamin D deficiency and its determinants in Australian adults aged 25 years and older: a national, population-based study. Clin Endocrinol. 77 : 26-35 View in Article Scopus (13)

PubMed

Crossref

Google Scholar

Clemens T.L.

Adams J.S.

Henderson S.L.

Holick M.F. Increased skin pigment reduces the capacity of skin to synthesise vitamin D 3 . Lancet. 1 : 74-76 View in Article PubMed

Abstract

Google Scholar

Manicourt D.H.

Devogelaer J.P. Urban tropospheric ozone increases the prevalence of vitamin D deficiency among Belgian postmenopausal women with outdoor activities during summer. J Clin Endocrinol Metab. 93 : 3893-3899 View in Article Scopus (20)

PubMed

Crossref

Google Scholar

van den Berg G.

van Eijsden M.

Vrijkotte T.G.

Gemke R.J. Suboptimal maternal vitamin D status and low education level as determinants of small-for-gestational-age birth weight. Eur J Nutr. 52 : 273-279 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Godar D.E.

Pope S.J.

Grant W.B.

Holick M.F. Solar UV doses of young Americans and vitamin D 3 production. Environ Health Perspect. 120 : 139-143 View in Article PubMed

Crossref

Google Scholar

MacLaughlin J.

Holick M.F. Aging decreases the capacity of human skin to produce vitamin D 3 . J Clin Invest. 76 : 1536-1538 View in Article PubMed

Crossref

Google Scholar

Signorello L.B.

Shi J.

Cai Q.

et al. Common variation in vitamin D pathway genes predicts circulating 25-hydroxyvitamin D levels among African Americans. PLoS One. 6 : e28623 View in Article Scopus (16)

PubMed

Crossref

Google Scholar

Engelman C.D.

Fingerlin T.E.

Langefeld C.D.

et al. Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab. 93 : 3381-3388 View in Article Scopus (73)

PubMed

Crossref

Google Scholar

Kennedy C.

Bajdik C.D.

Willemze R.

De Gruijl F.R.

Bouwes Bavinck J.N. The influence of painful sunburns and lifetime sun exposure on the risk of actinic keratoses, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer. J Invest Dermatol. 120 : 1087-1093 View in Article Scopus (140)

PubMed

Crossref

Google Scholar

Garland F.C.

White M.R.

Garland C.F.

Shaw E.

Gorham E.D. Occupational sunlight exposure and melanoma in the U.S. Navy. Arch Environ Health. 45 : 261-267 View in Article PubMed

Crossref

Google Scholar

Tangpricha V.

Turner A.

Spina C.

Decastro S.

Chen T.C.

Holick M.F. Tanning is associated with optimal vitamin D status (serum 25-hydroxyvitamin D concentration) and higher bone mineral density. Am J Clin Nutr. 80 : 1645-1649 View in Article PubMed

Google Scholar

Grant W.B. In defense of the sun: an estimate of changes in mortality rates in the United States if mean serum 25-hydroxyvitamin D levels were raised to 45 ng/mL by solar ultraviolet-B irradiance. Dermatoendocrinol. 1 : 207-214 View in Article PubMed

Crossref

Google Scholar

Dabai N.S.

Pramyothin P.

Holick M.F. The effect of ultraviolet radiation from a novel portable fluorescent lamp on serum 25-hydroxyvitamin D 3 levels in healthy adults with Fitzpatrick skin types II and III. Photodermatol Photoimmunol Photomed. 28 : 307-311 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Black L.J.

Seamans K.M.

Cashman K.D.

Kiely M. An updated systematic review and meta-analysis of the efficacy of vitamin D food fortification. J Nutr. 142 : 1102-1108 View in Article Scopus (6)

PubMed

Crossref

Google Scholar

Heaney R.P.

Davies K.M.

Chen T.C.

Holick M.F.

Barger-Lux M.J. Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 77 : 204-210 View in Article PubMed

Google Scholar

Demetriou E.T.

Travison T.G.

Holick M.F. Treatment with 50,000 IU vitamin D 2 every other week and effect on serum 25-hydroxyvitamin D 2 , 25-hydroxyvitamin D 3 , and total 25-hydroxyvitamin D in a clinical setting. Endocr Pract. 18 : 399-402 View in Article Scopus (4)

PubMed

Crossref

Google Scholar

Pietras S.M.

Obayan B.K.

Cai M.H.

Holick M.F. Vitamin D 2 treatment for vitamin D deficiency and insufficiency for up to 6 years. Arch Intern Med. 169 : 1806-1808 View in Article Scopus (38)

PubMed

Crossref

Google Scholar

Sanders K.M.

Stuart A.L.

Williamson E.J.

et al. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 303 : 1815-1822 View in Article Scopus (279)

PubMed

Crossref

Google Scholar

Trivedi D.P.

Doll R.

Khaw K.T. Effect of four monthly oral vitamin D 3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 326 : 469 View in Article PubMed

Crossref

Google Scholar

Lee J.M.

Smith J.R.

Philipp B.L.

Chen T.C.

Mathieu J.

Holick M.F. Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr. 46 : 42-44 View in Article Scopus (103)

PubMed

Crossref

Google Scholar

Hollis B.W.

Wagner C.L. Vitamin D requirements during lactation: high-dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant. Am J Clin Nutr. 80 : 1752S-1758S View in Article PubMed

Google Scholar

Chandra P.

Wolfenden L.L.

Ziegler T.R.

et al. Treatment of vitamin D deficiency with UV light in patients with malabsorption syndromes: a case series. Photodermatol Photoimmunol Photomed. 23 : 179-185 View in Article Scopus (23)

PubMed

Crossref

Google Scholar

Biancuzzo R.M.

Clarke N.

Reitz R.E.

Travison T.G.

Holick M.F. Serum concentrations of 1,25-dihydroxyvitamin D 2 and 1,25-dihydroxyvitamin D 3 in response to vitamin D 2 and vitamin D 3 supplementation. J Clin Endocrinol Metab. 98 : 973-979 View in Article Scopus (3)

PubMed

Crossref

Google Scholar

Holick M.F.

Biancuzzo R.M.

Chen T.C.

et al. Vitamin D 2 is as effective as vitamin D 3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab. 93 : 677-681 View in Article Scopus (314)

PubMed

Crossref

Google Scholar

Thacher T.D.

Fischer P.R.

Obadofin M.O.

Levine M.A.

Singh R.J.

Pettifor J.M. Comparison of metabolism of vitamins D 2 and D 3 in children with nutritional rickets. J Bone Miner Res. 25 : 1988-1995 View in Article Scopus (10)

PubMed

Crossref

Google Scholar

Keegan R.

Lu Z.

Bogusz J.

Holick M. Photobiology of vitamin D in mushrooms and its bioavailability in humans. Dermato-Endocrinology. 5 : 1 View in Article Scopus (1)

Crossref

Google Scholar