Since the 19th century, the average human body temperature in the United States has dropped, according to researchers at the Stanford University School of Medicine.

“Our temperature’s not what people think it is,” said Julie Parsonnet, MD, professor of medicine and of health research and policy. “What everybody grew up learning, which is that our normal temperature is 98.6, is wrong.”

That standard of 98.6 degrees Fahrenheit was made famous by German physician Carl Reinhold August Wunderlich, who published the figure in a book in 1868. Modern studies, however, have called that number into question, suggesting that it’s too high. A recent study, for example, found the average temperature of 25,000 British patients to be 97.9 F.

In a study published today in eLife, Parsonnet and her colleagues explore body temperature trends and conclude that temperature changes since the time of Wunderlich reflect a true historical pattern, rather than measurement errors or biases. Parsonnet, who holds the George DeForest Barnett Professorship, is the senior author. Myroslava Protsiv, a former Stanford research scientist who is now at the Karolinska Institute, is the lead author.

The researchers propose that the decrease in body temperature is the result of changes in our environment over the past 200 years, which have in turn driven physiological changes.

Digging into the past

Parsonnet and her colleagues analyzed temperatures from three datasets covering distinct historical periods. The earliest set, compiled from military service records, medical records and pension records from Union Army veterans of the Civil War, captures data between 1862 and 1930 and includes people born in the early 1800s. A set from the U.S. National Health and Nutrition Examination Survey I contains data from 1971 to 1975. Finally, the Stanford Translational Research Integrated Database Environment comprises data from adult patients who visited Stanford Health Care between 2007 and 2017.

The researchers used the 677,423 temperature measurements from these datasets to develop a linear model that interpolated temperature over time. The model confirmed body temperature trends that were known from previous studies, including increased body temperature in younger people, in women, in larger bodies and at later times of the day.

The researchers determined that the body temperature of men born in the early to mid-1990s is on average 1.06 F lower than that of men born in the early 1800s. Similarly, they determined that the body temperature of women born in the early to mid-1990s is on average 0.58 F lower than that of women born in the 1890s. These calculations correspond to a decrease in body temperature of 0.05 F every decade.

As part of the study, the authors investigated the possibility that the decrease could simply reflect improvements in thermometer technology; thermometers used today are far more accurate than those used two centuries ago. “In the 19thcentury, thermometry was just beginning,” Parsonnet said.

To assess whether temperatures truly decreased, the researchers checked for body temperature trends within each dataset; for each historical group, they expected that measurements would be taken with similar thermometers. Within the veterans dataset, they observed a similar decrease for each decade, consistent with observations made using the combined data.