In this episode, Francisco Gonzalez-Lima, a Professor of Neuroscience and Pharmacology & Toxicology, explains the vascular hypothesis of Alzheimer’s disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration. He walks us through the ways we can intervene in this process and also shares details of the exciting future of Alzheimer’s treatment and prevention.

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Featured image credit: Quasar Jarosz at English Wikipedia [CC BY-SA 3.0 or GFDL]

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Francisco Gonzalez-Lima, Ph.D.

Francisco Gonzalez-Lima holds the George I. Sanchez Centennial Professorship at The University of Texas at Austin, where he is a professor in the Departments of Psychology, Pharmacology and Toxicology, and Psychiatry, and the Institute for Neuroscience.

Gonzalez-Lima’s teaching experience includes undergraduate, medical, graduate and postdoctoral students, and he currently teaches the core graduate course in Functional Neuroanatomy. Gonzalez-Lima has been the research adviser of 22 Ph.D. students at UT Austin, and his trainees are world leaders in brain research on the relationship between brain energy metabolism, memory, and neurobehavioral disorders.

Gonzalez-Lima graduated with honors from Tulane University in New Orleans with B.S. (biology) and B.A. (psychology) degrees, and he earned his Ph.D. (anatomy and neurobiology) from the University of Puerto Rico School of Medicine, which honored him with a Distinguished Alumnus Award. He completed postdoctoral training (behavioral neuroscience) at the Technical University of Darmstadt, Germany, as an Alexander von Humboldt research fellow.

Gonzalez-Lima has been a visiting neuroscientist in Germany, England, Canada, and Spain, and he has delivered more than 120 invited lectures about his brain research around the world. His research has been funded for more than 30 years with federal and private funds, and he has contributed to more than 350 scientific publications in peer-reviewed journals, conference proceedings, chapters, and books.

Current research in the Gonzalez-Lima laboratory focuses on the beneficial neurocognitive and emotional effects of noninvasive human brain stimulation in healthy, aging and mentally ill populations. This research primarily uses transcranial infrared laser stimulation and multimodal imaging (EEG, fNIRS, and fMRI) in collaboration with colleagues at UT Austin, The University of Texas at Arlington and University of Texas Southwestern Medical Center. Gonzalez-Lima supervises and trains students and residents to contribute to these ongoing brain research projects. [utexas.edu]