Kyler Murray replaced a Heisman Trophy winner by becoming a Heisman Trophy winner.

Murray, the Oklahoma quarterback, won the Heisman, college football’s most prestigious individual award Saturday night, edging Tua Tagovailoa of Alabama and setting up a College Football Playoff matchup of Heisman winner versus runner-up.

“This is crazy,” Murray said in his acceptance speech. “This is an honor, something that I’ll never forget. Something that I’ll always cherish for the rest of my life.”

The fourth-ranked Sooners play the top-ranked Crimson Tide in the Orange Bowl semifinal on Dec. 29 in the seventh bowl matchup of Heisman winner and runner-up, and the first since the second-place finisher Vince Young and Texas beat Reggie Bush and Southern California in the 2006 Rose Bowl.

This season, Murray stepped into the starting job held by last year’s Heisman winner and first overall N.F.L. draft pick, Baker Mayfield. Oklahoma is the first team with have Heisman-winning quarterbacks in consecutive seasons and the fifth over all with winners in back-to-back years. Mayfield was also a finalist in 2016.