Queensland Opposition Leader Deb Frecklington has been accused of a "low act" for appearing to suggest Premier Annastacia Palaszczuk was less suited to lead because she is not a mother.

Key points: Deb Frecklington said Annastacia Palaszczuk was "too much" and said her own children kept her "grounded"

Deb Frecklington said Annastacia Palaszczuk was "too much" and said her own children kept her "grounded" One Labor MP said "attacking [Palaszczuk] for not being a mum is a low act"

One Labor MP said "attacking [Palaszczuk] for not being a mum is a low act" Ms Frecklington said Labor was trying to "twist the love I have for my kids for some warped political gain"

In an interview with News Corp's Sunday Mail, Ms Frecklington took aim at "Princess Palaszczuk", accusing her of wearing designer clothes and having a "complete makeover".

"She has deliberately changed her image — the whole 'Princess Palaszczuk' is pretty obvious — but I haven't changed mine," she told the paper.

"I have no choice but to remain grounded, because of [husband] Jason and the girls.

"I can have a tough day but then I'll get a call from one of my kids and you've got to deal with whatever's going on in their lives.

"She, on the other hand, has had a complete makeover — all the makeup, the designer labels, it's too much, when there are bigger issues to focus on.

"Whenever anyone brings up that Palaszczuk and I look similar, I think, thank goodness that I am nowhere near like her."

Ms Palaszczuk has been diagnosed with endometriosis and spoken openly about her fertility struggles in the past.

Federal Labor Member for Griffith Terri Butler accused Ms Frecklington of attacking Ms Palaszczuk "for not being a mum."

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Ms Frecklington declined the ABC's requests for an interview, and instead sent through a written statement.

"I was simply pointing out my real world experience and that my kids keep me grounded," she said.

"I won't stand by and allow the Labor Party to try and twist the love I have for my kids for some warped political gain."

A spokesperson for the Premier advised she would not be commenting on the matter personally.

'Play the ball, not the woman'

Other Labor MPs also came to the Premier's defence.

Deputy Premier Jackie Trad said politicians needed to present well as part of the job, and said she "didn't care" where anyone's clothes came from.

"We've got a job to do, we've got to present, whether that's to international investors, visiting dignitaries, there's a whole range of things we have to do in our day," she said.

"How an individual dresses should not be the subject of political conversation.

"The last time I saw this level of meanness was when I watched the movie Mean Girls.

"Politics has progressed on from this silly notion that how a woman looks in politics should be the subject of conversation, what we should be talking about is policies.

"There is no place for this in politics."

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Ms Frecklington's comments also made ripples across the border and reached federal politics, with former NSW premier and current federal Deputy Leader of the Opposition in the Senate Kristina Keneally weighing in.

"As premier, I wore everything from Scanlan & Theodore to Target to op-shop clothes … be part of the solution, not part of the problem," she said.

"And it's well past time to be attacking a female politician for her clothes — yet it still keeps happening. Play the ball, not the woman."

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Federal Opposition Leader Anthony Albanese also voiced criticism on Twitter, saying the comments made by Ms Frecklington were "appalling, pathetic and unbecoming".

But former Queensland attorney-general and LNP politician Jarrod Bleijie backed Ms Frecklington's comments.

"I've long said that AnnastaciaMP is a princess Premier. She prefers the red carpet of Hollywood, the glitz, the glamour the celebrities … but has no idea of what's actually happening in her government or state," he said on Twitter.

'It shouldn't matter what clothes you wear'

Queensland Police Minister Mark Ryan said he had not heard from Ms Palaszczuk personally but said he thought the comments were "mean and nasty".

"It shouldn't matter what kind of clothes you wear, it's how you do your job," he said.

"This nasty personal attack is no different to anything Campbell Newman would have done, she's cut from the same cloth."

Ms Palaszczuk's Labor colleagues have come to her defence. ( ABC Gold Coast: Dominic Cansdale )

It is not the first time a female politician's fashion choices have been used to dress-down their political accomplishments.

In 2016, then-British prime minister Theresa May was criticised for being "out of touch" with voters for wearing "expensive" leather trousers.

Likewise, Natasha Stott Despoja famously strode into Parliament House in boots while Julie Bishop's stilettos became a symbol of female empowerment.