A United Nations talk aimed at stopping the proliferation of nuclear weapons has ended without agreement after proposals were blocked to make the Middle East a nuclear-free zone.

The conference on the review of the Nuclear Non-Proliferation Treaty (NPT), an an international treaty intended to stop the spread of nuclear weapons and further the goal of nuclear disarmament, failed when the USA blocked plans to hold a Middle East conference which would try to making the region free of nuclear weapons.

The conference began on 28 April, and Egypt's proposal was rejected on 22 May.

Egypt led the way in trying to set a deadline for a conference that would aim to make the Middle East a nuclear-free zone.

John Kerry addresses the review conference on the Nuclear Non-Proliferation Treaty, which ended in failure after the USA blocked plans to call a Middle East conference. (TIMOTHY A. CLARY/AFP/Getty Images)

However, their plans were shut down by the USA, supported by the UK and Canada, who accused Egypt of attempting to "cynically manipulate" the process, by trying to organise a conference without an agenda agreed by all attendees, including the nuclear state of Israel.

Israel is believed to have a large nuclear weapons programme, and would likely object to many terms of an agenda made for such a conference.

Rose Gottemoeller, the US Under Secretary for Arms Control and International Security, said the terms of Egypt's proposal were against the USA's "long standing policies" on the matter.

A nuclear-capable missile is paraded through Islamabad, Pakistan, in 2005. Pakistan, along with India, Israel, and South Sudan, are the only nations that have not signed the Nuclear Non-Proliferation Treaty. (FAROOQ NAEEM/AFP/Getty Images)

She said the USA supported the idea of nuclear-free zones, but added that they should be formed with the "full mutual consent" of the nations in those regions. Egypt's call for a conference that Israel would object to therefore goes against this.

Egypt reacted angrily, claiming the veto will have "consequences in the in front of the Arab world and public opinion".

The failure of the conference to make any real progress has set back the goal of the treaty by at least five years, as the next treaty review conference can only next take place in 2020.

The UK supported the USA in blocking the proposal for a Middle East nuclear non-proliferation conference (Andy Buchanan/AFP/Getty Images)

Analysts believe that the proposed Middle East conference would have necessarily required Israel to reveal what many nations believe to be an extensive nuclear weapons programme.

Israel has never publicly declared whether or not it has a nuclear weapons programme, and their objections to the conference could be behind the USA's veto - this week, a senior US State Department official was sent to Israel to discuss their issues with the NPT conference.