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Early last week, Bills wide receiver Sammy Watkins said missing games because of his surgically repaired foot was “out the window.”

At some point after that, Watkins’ foot was stepped on in practice and now worry is mounting that Watkins’ season may be out the window.

Watkins didn’t play in last Sunday’s 33-18 win over the Cardinals and he has been ruled out again this week after failing to get on the practice field at all. Beyond that, Bills coach Rex Ryan said in his Friday press conference that there is “major concern” about Watkins’ availability as the season moves forward.

There was a report to that effect from Manish Mehta of the New York Daily News coming out of the first week of the season, although Watkins shrugged them off by saying that his foot was merely “tired.” He went on to play against the Jets in Week Two, but didn’t look like the same kind of downfield threat that he was in his first two seasons.

The Bills were able to adapt well enough to win without him last week, but the loss of Watkins would be a hard thing for them to overcome on a weekly basis while still winning enough to make a push for a long-awaited playoff bid.