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Losing 48-28 in the first game of the season is a tough pill to swallow.

It’s even tougher when it comes with a side dish of injury. That’s what Buffalo is dealing with after spotting the Jets a 41-7 lead en route to Sunday’s loss. Running back Fred Jackson and wide receiver David Nelson both left the game with knee injuries and the news on Nelson doesn’t sound good.

Nelson got hurt when making a cut away from the play in the fourth quarter and did not return to the game. After the contest, coach Chan Gailey said that the team fears Nelson has suffered a serious injury.

“Fred doesn’t look as bad as David,” Gailey said, via Tim Graham of the Buffalo News. “We don’t know how bad David is, but it doesn’t look good right now.”

Graham reports that the team believes Jackson suffered a sprain, although both players have dates scheduled with the MRI machine. C.J. Spiller’s strong performance lessens some of the blow if Jackson is forced to miss much time as a result of the injury.

Nelson was Buffalo’s second-leading receiver last year with 61 catches for 658 yards and five touchdowns. He had two catches for 31 yards on Sunday. The Bills only had four full-time receivers on their 53-man roster coming into Sunday’s game and rookie T.J. Graham was inactive against the Jets.

UPDATE 7:20 p.m. ET: PFT has learned that the Bills believe Nelson has a torn ACL.