Homer and Marge are one of TV's longstanding couples, sticking it out for over 26 seasons now - the series has been on since 1989.

However, in an interview with Variety, the series' executive producer Al Jean has revealed the the animated couple are headed for a split in the upcoming 27th season, set to begin this fall.

'It’s discovered after all the years Homer has narcolepsy - a chronic neurological disorder that affects the control of sleep, causing uncontrollable episodes of falling asleep, even during activities that demand attention - and it’s an incredible strain on the marriage,' he spilled.

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Calling it quits: The Simpsons' executive producer Al Jean revealed to Variety that in the upcoming 27th season, Homer and Marge will legally separate

However, the narcolepsy isn't the only thing to blame, as the EP shared that Homer has his eyes on another woman.

The new apple of Homer's eye will be one of the upcoming season's many guest stars, and is coming off of another guest stint, on popular ABC series Scandal.

'Homer and Marge legally separate, and Homer falls in love with his pharmacist, who’s voiced by Lena Dunham,' Al shared, adding: 'We’ll have cameos from the other women from Girls.'

Previously, Homer had considered cheating on his longtime spouse in a season five episode titled The Last Temptation of Homer, which first aired in 1993.

The cartoon dad went so far as to visit a hotel room with new coworker Mindy (voiced by Michelle Pfeiffer), though he was plagued with guilt because of Marge and the kids, and eventually called it off, reuniting with his loving wife.

Saturday Night Live's Kate McKinnon will also make a guest appearance on the season, as 'a homeless woman who turns out to be an incredible singer.'

Guest stars: Al also discussed upcoming guest stars, such as Kate McKinnon (L) who will voice a homeless woman befriended by Lisa, and Girls' Lena Dunham who voices Homer's pharmacist, who he falls in love with

She will be befriended by Lisa in one episode, in which the singing will be performed by Natalie Maines.

But hope you didn't put away those tissues, because in more bad news, the EP revealed that Sideshow Bob will also make an appearance, in which 'we finally see him do something he's wanted to do for 25 years.'

Speaking at the ATX Festival panel in Texas, Al shared that the cartoon schoolboy is set to fall victim to a diabolical plan by his arch rival in the upcoming Halloween special, Treehouse of Horror XXVI, which will be broadcast in the autumn.

His reasoning was because he had always felt 'frustration' when the Coyote never killed the Road Runner in the animated children's show Looney Tunes.

'We'll scratch that itch' On the Halloween episode, Sideshow Bob will make an appearance, and fans will 'finally see him do something he's wanted to do for 25 years'

He said: 'I hated frustration comedy so we'll scratch that itch.'

'So Bob will finally somehow actually execute Bart - and then won't know what to do with himself after his life's mission has been accomplished.'

However, fans can rest assured that the murderous scenes will not mean the end of the show or the son of Homer Simpson, as the episode is a one-off Halloween special, meaning he will be back to normal in subsequent episodes.

On a lighter note, Al also shared that Spider Pig - akak Plopper, Homer's pal from The Simpsons Movie - is set to make his return in an upcoming episode.

And there will be a Bart-centric episode based on the Oscar-nominated film Boyhood, which will feature a flashback/flash forward motif.

Al explained: 'We go to various points in his life and his life to come which I think came out really well.'

The EP also discussed the upcoming election, speaking on whether or not the popular cartoon dad would be casting his vote.

'We’re definitely going to have Homer vote in 2016,' he gushed. 'One aspect of the pickup that made me happy is that Homer can vote again.'

Sincerest form of flattery: The upcoming season also boasts an episode based on the Oscar-nominated film Boyhood

'He voted for Romney in 2012 because he invented Obamacare. He tried to vote for Obama in 2008 but all his votes went to McCain.'

When asked for hints about the upcoming vote, Al teased: 'We’re not sure who the candidates are yet, but whatever he wants it’s not going to happen.'