Ignoring her family’s request that her death — allegedly at the hands of an illegal Mexican immigrant — not be politicized, Donald Trump Jr. penned a fire-breathing anti-immigrant screed for an Iowa newspaper over the killing of Mollie Tibbetts.

“The reaction from some Democrats and others on the left to the murder of Mollie Tibbetts is as despicable as it is revealing,” President Trump’s eldest son wrote in the op-ed, published Friday in The Des Moines Register.

“The mask is off and the true radical face of the Democrats has been exposed. They are seemingly more concerned with protecting their radical open-borders agenda than the lives of innocent Americans.”

He then slammed Sen. Elizabeth Warren for what he called her tepid response to Tibbetts’ killing, allegedly by undocumented 24-year-old farm worker Cristhian Bahena Rivera.

Warren, Trump Jr. said, “played down the killing and said the focus should be on the ‘real problems’ of our immigration system, such as the separation of families at our border” — a reference to his father’s zero-tolerance policy on illegal immigration, which resulted in more than 2,500 migrant children being forcibly separated from their parents.

“Think about that for a minute. She apparently believes that illegal alien parents being separated from their children is a bigger problem than American parents having to bury theirs,” he wrote.

Warren, however, also expressed sympathy for the family and the need for immigration reform after the suspect was arrested, the paper pointed out in an editor’s note.

“I’m so sorry for the family here, and I know this is hard not only for her family, but for people in her community, the people throughout Iowa. But one of the things we have to remember is we need an immigration system that is effective, that focuses on where real problems are,” the Massachusetts Democrat told CNN.

“I think we need immigration laws that focus on people who pose a real threat and I don’t think mamas and babies are the place we should be spending our resources,” Warren added.

Echoing his father, Trump Jr. also lashed out at the media for supposedly underplaying the suspect’s immigration status — which was widely reported across the country.

“Liberal media outlets went through great pains to cover the story without actually covering the story. Instead of truthful headlines such as ‘Illegal immigrant arrested in connection with murder of Mollie Tibbetts,’ multiple outlets ran headlines such as ‘Man arrested in connection to disappearance of Mollie Tibbetts.’ They don’t want you to know what happened to her — and they certainly don’t want you to know who is responsible,” he charged.

And he repeated his father’s false statement that Democrats only want ”open borders” and said that if “his dad’s policies” had been enacted years ago tragedies such as Tibbetts’ death would never happen.

“The Left is so ideologically committed to open borders that they can’t be honest about the consequences of illegal immigration. If the mainstream media reported objectively about illegal alien crime — not to mention the effects of cheap illegal immigrant labor on the labor market — the wall would have been built years ago and my dad’s policies at the border would be implemented immediately,” Trump Jr. wrote, adding that Democrats should be “voted out.”

Tibbetts’ body was found in a cornfield in early August, about a month after the 20-year-old college student vanished after going for a run from her Brooklyn, Iowa home.

Her father, Rob Tibbetts, thanked the local Hispanic community for the support they offered while he searched for his daughter, and other family members begged people to not exploit her death for political reasons.

“I don’t want Mollie’s memory to get lost amongst politics,” Tibbetts’ aunt, Billie Jo Calderwood told CNN.

“It’s not about race, it’s about people joining together to do good.”

The paper’s opinion editor, Kathie Obradovich, defended the decision to publish Trump Jr.’s column.

“We deeply respect the Tibbetts family and we used our own editorial voice to support the position that undocumented immigrants in general are not responsible for this tragedy. But we continue to do our job and our pages reflect the conversations in our community, even when it means publishing opinions with which we strongly disagree,” she wrote in an email to The Post.

Readers reaction in the paper’s comment section was mixed.

“I’m not surprised that Donald Trump Jr. would think these things or that he would write them. I’m not disappointed in Donald Trump Jr. because this is exactly the sort of nonsense I expect from him,” wrote Phil Brown.

“I am, however, extremely disappointed in the Des Moines Register Editorial and Opinion Section staff that allowed this mockery of a guest column to be published. There is simply no justification for the Register to subject its audience to this crap. Do better. Please.”

But a reader identified as Antonio Gambino disagreed.

“Why are you leftists so adamant on totally open borders and unfettered mass immigration? Give me one reason why its so great. Try me. I dare any of you tools will have the guts and will only give me the usual mealy mouthed bulls&%$te,” Gambino wrote.