1. Turner RC

Cull CA

Frighi V

Holman RR

for the UK Prospective Diabetes Study (UKPDS) Group Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA. 281 : 2005-2012 View in Article Scopus (1977)

PubMed

Crossref

Google Scholar

2. Diabetes UK Diabetes: the basics. Diabetes UK. https://www.diabetes.org.uk/Diabetes-the-basics/ Date: 2017 Date accessed: April 20, 2019 View in Article Google Scholar

3. Public Health England Adult obesity and Diabetes.co.uk, accepting the diagnosis. https://www.diabetes.co.uk/emotions/coping-with-diabetes-diagnosis.html Date accessed: April 20, 2019 View in Article Google Scholar

5. Petersen KF

Dufour S

Befroy D

Lehrke M

Hendler RE

Shulman GI Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes. 54 : 603-608 View in Article Scopus (578)

PubMed

Crossref

Google Scholar

8. Adiels M

Taskinen MR

Packard C

et al. Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia. 49 : 755-765 View in Article Scopus (443)

PubMed

Crossref

Google Scholar

11. Lingvay I

Guth E

Islam A

Livingston E Rapid improvement in diabetes after gastric bypass surgery: is it the diet or surgery?. Diabetes Care. 36 : 2741-2747 View in Article Scopus (68)

PubMed

Crossref

Google Scholar

12. Steven S

Hollingsworth KG

Small PK

et al. Calorie restriction and not glucagon-like peptide-1 explains the acute improvement in glucose control after gastric bypass in type 2 diabetes. Diabet Med. 33 : 1723-1731 View in Article Scopus (19)

PubMed

Crossref

Google Scholar

13. NHS England NHS England announce type 2 remission pilot, and plans to double the size of the NHS England Diabetes Prevention Programme. https://www.england.nhs.uk/2018/11/very-low-calorie-diets-part-of-nhs-action-to-tackle-growing-obesity-and-type-2-diabetes-epidemic/ Date: Dec 14, 2018 Date accessed: April 20, 2019 View in Article Google Scholar

14. Davies MJ

D'Alessio DA

Fradkin J

et al. Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 41 : 2669-2701 View in Article Scopus (688)

PubMed

Crossref

Google Scholar

16. Taylor R

Barnes AC Can type 2 diabetes be reversed and how can this best be achieved? James Lind Alliance research priority number one. Diabet Med. 36 : 308-315 View in Article Scopus (9)

PubMed

Crossref

Google Scholar

17. Petersen KF

Dufour S

Savage DB

et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci USA. 104 : 12587-12594 View in Article Scopus (435)

PubMed

Crossref

Google Scholar

18. UK Prospective Diabetes Study Group UK Prospective Diabetes Study 16: overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes. 44 : 1249-1258 View in Article Scopus (1663)

PubMed

Crossref

Google Scholar

19. Rudenski AS

Hadden DR

Atkinson AB

et al. Natural history of pancreatic islet B-cell function in type 2 diabetes mellitus studied over six years by homeostasis model assessment. Diabet Med. 5 : 36-41 View in Article Scopus (66)

PubMed

Crossref

Google Scholar

20. Butler AE

Cao-Minh L

Galasso R

et al. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia. 53 : 2167-2176 View in Article Scopus (241)

PubMed

Crossref

Google Scholar

21. Rahier J

Guiot Y

Goebbels RM

Sempoux C

Henquin JC Pancreatic β-cell mass in European subjects with type 2 diabetes. Diabetes Obes Metab. 10 : 32-42 View in Article Scopus (462)

PubMed

Crossref

Google Scholar

22. Sattar N

McConnachie A

Ford I

et al. Serial metabolic measurements and conversion to type 2 diabetes in the West of Scotland Coronary Prevention Study: specific elevations in alanine aminotransferase and triglycerides suggest hepatic fat accumulation as a potential contributing factor. Diabetes. 56 : 984-991 View in Article Scopus (87)

PubMed

Crossref

Google Scholar

23. Seppala-Lindroos A

Vehkavaara S

Hakkinen AM

et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab. 87 : 3023-3028 View in Article Scopus (792)

PubMed

Crossref

Google Scholar

24. Ryysy L

Hakkinen A-M

Goto T

et al. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes. 49 : 749-758 View in Article Scopus (350)

PubMed

Crossref

Google Scholar

25. Taylor R

Magnussen I

Rothman DL

et al. Direct assessment of liver glycogen storage by 13C-nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects. J Clin Invest. 97 : 126-132 View in Article Scopus (187)

PubMed

Crossref

Google Scholar

26. Lim EL

Hollingsworth KG

Aribisala BS

Chen MJ

Mathers JC

Taylor R Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia. 54 : 2506-2514 View in Article Scopus (554)

PubMed

Crossref

Google Scholar

28. Singhal P

Caumo A

Carey PE

Cobelli C

Taylor R Regulation of endogenous glucose production after a mixed meal in type 2 diabetes. Am J Physiol Endocrinol Metab. 283 : E275-E283 View in Article Scopus (59)

PubMed

Crossref

Google Scholar

29. Kelley DE

Wing R

Buonocore C

Sturis J

Polonsky K

Fitzsimmons M Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 77 : 1287-1293 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

30. Henry RR

Wallace P

Olefsky JM Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus. Diabetes. 35 : 990-998 View in Article Scopus (263)

PubMed

Crossref

Google Scholar

32. Ravikumar B

Gerrard J

Dalla Man C

et al. Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content. Diabetes. 57 : 2288-2295 View in Article Scopus (45)

PubMed

Crossref

Google Scholar

33. Pories WJ

Swanson MS

MacDonald KG

et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann Surg. 222 : 339-350 View in Article Scopus (1769)

PubMed

Crossref

Google Scholar

37. Apostolopoulou M

Gordillo R

Koliaki C

et al. Specific hepatic sphingolipids relate to insulin resistance, oxidative stress, and inflammation in nonalcoholic steatohepatitis. Diabetes Care. 41 : 1235-1243 View in Article Scopus (54)

PubMed

Crossref

Google Scholar

38. Lee Y

Hirose H

Ohneda M

Johnson JH

McGarry JD

Unger RH β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte–β-cell relationships. Proc Natl Acad Sci USA. 91 : 10878-10882 View in Article Scopus (645)

PubMed

Crossref

Google Scholar

40. Unger RH Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: genetic and clinical implications. Diabetes. 44 : 863-870 View in Article PubMed

Crossref

Google Scholar

41. Pinnick K

Neville M

Clark A

Fielding B Reversibility of metabolic and morphological changes associated with chronic exposure of pancreatic islet β-cells to fatty acids. J Cell Biochem. 109 : 683-692 View in Article PubMed

Google Scholar

42. Pinnick KE

Collins SC

Londos C

Gauguier D

Clark A

Fielding BA Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity (Silver Spring). 16 : 522-530 View in Article Scopus (109)

PubMed

Crossref

Google Scholar

43. Huang CJ

Lin CY

Haataja L

et al. High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated β-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes. 56 : 2016-2027 View in Article Scopus (288)

PubMed

Crossref

Google Scholar

44. Laybutt DR

Preston AM

Akerfeldt MC

et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia. 50 : 752-763 View in Article Scopus (563)

PubMed

Crossref

Google Scholar

45. Poitout V

Amyot J

Semache M

Zarrouki B

Hagman D

Fontés G Glucolipotoxicity of the pancreatic beta cell. Biochim Biophys Acta. 1801 : 289-298 View in Article Scopus (214)

PubMed

Crossref

Google Scholar

46. Al-Mrabeh A

Hollingsworth KG

Steven S

Taylor R Morphology of the pancreas in type 2 diabetes: effect of weight loss with or without normalisation of insulin secretory capacity. Diabetologia. 59 : 1753-1759 View in Article Scopus (20)

PubMed

Crossref

Google Scholar

47. Al-Mrabeh A

Hollingsworth KG

Steven S

Tiniakos D

Taylor R Quantification of intrapancreatic fat in type 2 diabetes. PLoS One. 12 : e0174660 View in Article Scopus (15)

PubMed

Crossref

Google Scholar

48. van der Zijl NJ

Goossens GH

Moors CC

et al. Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on β-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metab. 96 : 459-467 View in Article Scopus (110)

PubMed

Crossref

Google Scholar

49. Kuhn JP

Berthold F

Mayerle J

et al. Pancreatic steatosis demonstrated at MR imaging in the general population: clinical relevance. Radiology. 276 : 129-136 View in Article Scopus (45)

PubMed

Crossref

Google Scholar

50. Steven S

Hollingsworth KG

Al-Mrabeh A

et al. Very low calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiological changes in responders and nonresponders. Diabetes Care. 39 : 158-165 View in Article Scopus (32)

PubMed

Crossref

Google Scholar

51. Steven S

Hollingsworth KG

Small P

et al. Weight loss decreases excess pancreatic triacylglycerol specifically in type 2 diabetes. Diabetes Care. 39 : 158-165 View in Article Scopus (60)

PubMed

Crossref

Google Scholar

52. Tushuizen ME

Bunck MC

Pouwels PJ

et al. Pancreatic fat content and β-cell function in men with and without type 2 diabetes. Diabetes Care. 30 : 2916-2921 View in Article Scopus (227)

PubMed

Crossref

Google Scholar

53. Szczepaniak LS

Victor RG

Mathur R

et al. Pancreatic steatosis and its relationship to β-cell dysfunction in humans: racial and ethnic variations. Diabetes Care. 35 : 2377-2383 View in Article Scopus (67)

PubMed

Crossref

Google Scholar

54. Redmon JB

Bertoni AG

Connelly S

et al. Effect of the Look AHEAD study intervention on medication use and related cost to treat cardiovascular disease risk factors in individuals with type 2 diabetes. Diabetes Care. 33 : 1153-1158 View in Article Scopus (67)

PubMed

Crossref

Google Scholar

55. Sjostrom L Review of the key results from the Swedish Obese Subjects (SOS) trial—a prospective controlled intervention study of bariatric surgery. J Intern Med. 273 : 219-234 View in Article Scopus (815)

PubMed

Crossref

Google Scholar

56. Sevastianova K

Santos A

Kotronen A

et al. Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr. 96 : 427-434 View in Article Scopus (116)

Crossref

Google Scholar

57. Targher G

Bertolini L

Rodella S

et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care. 30 : 2119-2121 View in Article Scopus (338)

PubMed

Crossref

Google Scholar

58. Perry RJ

Samuel VT

Petersen KF

Shulman GI The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 510 : 84-91 View in Article Scopus (505)

PubMed

Crossref

Google Scholar

59. Lim S

Bae JH

Chun EJ

et al. Differences in pancreatic volume, fat content, and fat density measured by multidetector-row computed tomography according to the duration of diabetes. Acta Diabetol. 51 : 739-748 View in Article Scopus (32)

PubMed

Crossref

Google Scholar

60. Lalloyer F

Vandewalle B

Percevault F

et al. Peroxisome proliferator-activated receptor α improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. Diabetes. 55 : 1605-1613 View in Article Scopus (89)

PubMed

Crossref

Google Scholar

61. Finlayson G

Bryant E

Blundell JE

King NA Acute compensatory eating following exercise is associated with implicit hedonic wanting for food. Physiol Behav. 97 : 62-67 View in Article Scopus (112)

PubMed

Crossref

Google Scholar

62. Hopkins M

Blundell JE

King NA Individual variability in compensatory eating following acute exercise in overweight and obese women. Br J Sports Med. 48 : 1472-1476 View in Article Scopus (44)

PubMed

Crossref

Google Scholar

63. King NA

Horner K

Hills AP

et al. Exercise, appetite and weight management: understanding the compensatory responses in eating behaviour and how they contribute to variability in exercise-induced weight loss. Br J Sports Med. 46 : 315-322 View in Article Scopus (95)

PubMed

Crossref

Google Scholar

64. Wing RR

Phelan S Long-term weight loss maintenance. Am J Clin Nutr. 82 : 222S-225S View in Article PubMed

Crossref

Google Scholar

65. McCombie L

Leslie W

Taylor R

Kennon B

Sattar N

Lean MEJ Beating type 2 diabetes into remission. BMJ. 358 : j4030 View in Article Scopus (27)

PubMed

Crossref

Google Scholar

68. Gregg EW

Chen H

Wagenknecht LE

et al. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA. 308 : 2489-2496 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

70. Lotta LA

Gulati P

Day FR

et al. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat Genet. 49 : 17-26 View in Article Scopus (197)

PubMed

Crossref

Google Scholar

71. Peters C

Steven S

Taylor R Reversal of type 2 diabetes by weight loss despite presence of macro- and micro-vascular complications. in: Draznin B Diabetes case studies: real problems, practical solutions. American Diabetes Association , Alexandria : 271-274 View in Article Google Scholar

72. Doughty R Type 2 diabetes and the diet that cured me. The Guardian. https://www.theguardian.com/lifeandstyle/2013/may/12/type-2-diabetes-diet-cure Date accessed: April 20, 2019 View in Article Google Scholar

73. Brereton MF

Iberl M

Shimomura K

et al. Reversible changes in pancreatic islet structure and function produced by elevated blood glucose. Nat Commun. 5 : 4639 View in Article Scopus (102)

PubMed

Crossref

Google Scholar

74. Spijker HS

Song H

Ellenbroek JH

et al. Loss of β-cell identity occurs in type 2 diabetes and is associated with islet amyloid deposits. Diabetes. 64 : 2928-2938 View in Article Scopus (69)

PubMed

Crossref

Google Scholar

77. White MG

Marshall HL

Rigby R

et al. Expression of mesenchymal and α-cell phenotypic markers in islet β-cells in recently diagnosed diabetes. Diabetes Care. 36 : 3818-3820 View in Article Scopus (54)

PubMed

Crossref

Google Scholar

79. Sun J

Ni Q

Xie J

et al. B-Cell dedifferentiation in patients with T2D with adequate glucose control and nondiabetic chronic pancreatitis. J Clin Endocrinol Metab. 104 : 83-94 View in Article PubMed

Google Scholar

82. Sjostrom L

Peltonen M

Jacobson P

et al. Association of bariatric surgery with long-term remission of type 2 diabetes and with microvascular and macrovascular complications. JAMA. 311 : 2297-2304 View in Article Scopus (484)

PubMed

Crossref

Google Scholar

83. Pearce IA

Ilango B

Sells RA

Wong D Stabilisation of diabetic retinopathy following simultaneous pancreas and kidney transplant. Br J Ophthalmol. 84 : 736-740 View in Article Scopus (73)

PubMed

Crossref

Google Scholar

84. Arun CS

Pandit R

Taylor R Long-term progression of retinopathy after initiation of insulin therapy in type 2 diabetes: an observational study. Diabetologia. 47 : 1380-1384 View in Article Scopus (20)

PubMed

Crossref

Google Scholar

87. Gregg EW

Cheng YJ

Narayan KM

Thompson TJ

Williamson DF The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 1976–2004. Prev Med. 45 : 348-352 View in Article Scopus (110)

PubMed

Crossref

Google Scholar

88. Public Health England Adult obesity and type 2 diabetes. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/338934/Adult_obesity_and_type_2_diabetes_.pdf Date: July 2014 Date accessed: April 20, 2019 View in Article Google Scholar

89. Steven S

Carey PE

Small PK

Taylor R Reversal of type 2 diabetes after bariatric surgery is determined by the degree of achieved weight loss in both short- and long-duration diabetes. Diabet Med. 32 : 47-53 View in Article Scopus (29)

PubMed

Crossref

Google Scholar

90. Dixon JB

Chuang LM

Chong K

et al. Predicting the glycemic response to gastric bypass surgery in patients with type 2 diabetes. Diabetes Care. 36 : 20-26 View in Article Scopus (138)

PubMed

Crossref

Google Scholar

91. Steinarsson AO

Rawshani A

Gudbjornsdottir S

Franzen S

Svensson AM

Sattar N Short-term progression of cardiometabolic risk factors in relation to age at type 2 diabetes diagnosis: a longitudinal observational study of 100 606 individuals from the Swedish National Diabetes Register. Diabetologia. 61 : 599-606 View in Article Scopus (19)

PubMed

Crossref

Google Scholar