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A man has been arrested and will be charged with three counts of murder in connection with the disappearance of Alvin and Kathryn Liknes and their five-year-old grandson Nathan O'Brien.

The trio have not been found, but Calgary police chief Rick Hanson said investigators concluded on Sunday that they were dead and the suspect was arrested at 1:30 a.m. on Monday in the Airdrie area. Police are not looking for any other suspects.

The first degree murder charges relate to Alvin and Kathryn Liknes, the second-degree charge to Nathan O'Brien.

Due to the stage of the investigation, Hanson said he could not name the man who will be charged.

"The preponderance of evidence is such that is has led our investigators to believe they are dead.

"This investigation has been painstaking. This file has been built piece but piece by piece by piece. This has been the confirmation of an immense investigation."

Hanson offered his "sincere and heartfelt condolences" to the Liknes and O'Brien families.

"It's extremely tragic. It's devastated them. I think it's safe to say even as the days went by there's always a glimmer of hope. Unfortunately with the laying of charges we have taken the hope away from the family."

He asked people in the Airdrie community, where the bulk of the investigation has taken place, to remain vigilant and report anything pout of the ordinary to police.

He was confident bodies of the three would be found.