Forget Iron Man and Pepper Potts, or Black Widow and The Hulk – the greatest romance in the MCU is between Bruce Banner and Tony Stark, but Avengers: Infinity War may be about to bring that to an end.

Mark Ruffalo has revealed that, when Bruce returns after his Thor: Ragnarok adventure, he may no longer see eye-to-eye with the other half of the Science Bros.

"Banner's had a life-changing experience in Thor 3 that makes him much more expressive and not so internalised, you know?" he told Cinema Blend.

Disney

"So, it's not combative, but [Bruce and Tony are] not so in-sync as they were. Plus, Banner doesn't understand Civil War. He just doesn't get it."

The Hulk took a leave of absence from the team at the end of Avengers: Age of Ultron, and so missed the conflict between Stark and Steve Rogers in Captain America: Civil War.

This content is imported from YouTube. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

In Infinity War, Banner will apparently return to Earth via a hole in the roof of the Sanctum Sanctorum, before teaming up with Doctor Strange, Wong, Iron Man and, possibly, Spider-Man.

Bruce and Tony's friendship in the Marvel movies spawned the Science Bros meme, which naturally includes a ton of slash fiction and raunchy fan art. Back in 2013, Ruffalo was delighted to be introduced to the meme.

Avengers: Infinity War will be released on April 26 in the UK and April 27 in the US.

This content is imported from YouTube. You may be able to find the same content in another format, or you may be able to find more information, at their web site.

Want up-to-the-minute entertainment news and features? Just hit 'Like' on our Digital Spy Facebook page and 'Follow' on our @digitalspy Twitter account and you're all set.

This content is created and maintained by a third party, and imported onto this page to help users provide their email addresses. You may be able to find more information about this and similar content at piano.io