Republican presidential hopeful Jeb Bush on Saturday sneezed at the notion of serving as the running mate to primary front-runner Donald Trump Donald John TrumpHR McMaster says president's policy to withdraw troops from Afghanistan is 'unwise' Cast of 'Parks and Rec' reunite for virtual town hall to address Wisconsin voters Biden says Trump should step down over coronavirus response MORE.

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“No,” he responded sharply to a reporter in South Carolina, drawing laughs. “Let’s be clear: I don’t think he would ask me.”

Former Republican primary candidate Sen. Lindsey Graham Lindsey Olin GrahamThe Hill's Campaign Report: Arizona shifts towards Biden | Biden prepares for drive-in town hall | New Biden ad targets Latino voters Senate Democrats' campaign arm announces seven-figure investment to boost Graham challenger Graham: Comey to testify about FBI's Russia probe, Mueller declined invitation MORE (R-S.C.), who has endorsed Bush for president, can be seen chuckling at the suggestion, as well.

The former Florida governor has repeatedly questioned Trump’s conservatism and balked at the billionaire businessman’s abrasive manner.

Trump, for his part, has needled Bush as a “low-energy” candidate and accused his brother, former President George W. Bush, of lying about the Iraq invasion.