A Hunter Valley mother accused of poisoning her nine-year-old daughter with urine injections has appeared in a New South Wales court.

Newcastle's Child Abuse Squad began investigating in March this year after the girl was admitted to hospital with medical issues including life-threatening renal failure.

Police documents tendered to Cessnock Local Court alleged the girl's illnesses were caused by the woman injecting her daughter with urine.

The mother is also accused of giving the girl tablets that caused other problems.

The poisoning is alleged to have occurred between 5:24pm on March 11 this year and 5:42am the following morning.

There are a number of independent, medical witnesses.

Police charge papers said the life-threatening infections suffered by the girl had never before been seen by doctors.

The mother was charged with using poison to endanger her daughter's life, and inflicting grievous bodily harm.

The woman was granted bail on the condition that she not have any contact with the girl or with any medical professionals at John Hunter or Westmead hospitals.

Police had raised concern about bail, saying there was a risk the accused would endanger the safety of the victim or interfere with witnesses or evidence.

The defendant has not made any admissions and did not enter a plea in court. The maximum penalty for the offence is 10 years in jail.

The woman was supported by several family members and friends in court today.

Police said the child was recovering after being released from hospital earlier this year.

An apprehended violence order has also been taken out on behalf of the child.

The matter was adjourned to Newcastle Local Court on October 14.