Comedian Larry Wilmore remained composed through his anger as he told Milo Yiannopoulos 'go f*** yourself,' in response to comments made by the controversial conservative figure about the comedian's intelligence.

Yiannopoulos went on a five-minute rant against transgender people, saying that he did not want them in the bathroom with little girls, on Bill Maher's 'Overtime' on Friday night.

When the conversation got heated, Yiannopoulos criticized the rest of the panel, saying that Maher 'needs to start inviting higher IQ guests' onto the show.

In response to his calling dedicated counter terrorism official Malcom Nance and former Georgia representative Jack Kingston on the show's panel 'stupid' Wilmore couldn't hold himself back.

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Friday night's 'Overtime' with Bill Maher featured right-wing Breitbart columnist Milo Yiannopoulos (far right), former Georgia representative Jack Kingston (center), comedian Larry Wilmore (center left), and counter terrorism official Malcom Nance (far left)

L-R: Malcom Nance, Larry Wilmore, Jack Kingston. Wilmore remained composed through his anger as he told Milo Yiannopoulos 'go f*** yourself,' in response to comments made by the right-wing figure about the rest of the panel's intelligence

'If your argument is that these people are stupid you didn't hear a word this man said earlier in this segment because he can talk circles around your pathetic, douchey little a**,' Wilmore said to roars from the audience.

Yiannopoulos has been lauded by the alt-right movement as a face to their campaign.

Wilmore's outburst comes a few weeks after Yiannopoulos had to cancel a speaking event at the University of California-Berkeley because his presence sparked violent protests on campus.

The protests were enough to catch the President's attention, and Trump defended Yiannopoulos as a proponent of 'free speech'.

Milo Yiannopoulos is a staunch Trump supporter, and has been accused of peddling racism, xenophobia and Islamophobia. His following began on Breitbart while current White House chief strategist Steve Bannon was still in charge

Trump also threatened to cut federal funds to Berkeley unless it stopped perpetuating violence on 'innocent people'.

Yiannopoulos is a staunch Trump supporter, and has been accused of peddling racism, xenophobia and Islamophobia.

His following began on Breitbart while current White House chief strategist Steve Bannon was still in charge.

Earlier in the night, speaking to Maher, Yiannopoulos said: 'All I care about is free speech and free expression,' before criticizing democrats in America, saying that they 'take the bait' too easily

Wilmore (left) mentioned comments made about 'Ghostbusters' actress Leslie Jones on Friday night, telling the Breitbart editor: 'And one last thing, Leslie Jones is not "barely literate." Go f*** yourself again for that one'

Earlier in the night, speaking to Maher, Yiannopoulos said: 'All I care about is free speech and free expression,' before criticizing democrats in America, saying that they 'take the bait' too easily.

However, he has been criticized by many on both sides of the spectrum for comments that he made against 'Ghostbusters' and 'Saturday Night Live' star Leslie Jones.

Yiannopoulos viciously attacked the actress's performance in 'Ghostbusters' and has referred to her as 'illiterate'.

Wilmore mentioned it on Friday night, telling the Breitbart editor: 'And one last thing, Leslie Jones is not "barely literate." Go f*** yourself again for that one.'