Enabling this option makes it so a USB device is assigned to a specific user in their remote desktop session and is invisible to others. Now you can be safe that your USB device will not be occupied by other RDP sessions.

Per-user isolation

This option allows isolating a connected USB device from other Windows users. It will be useful when there is the constant switching between the accounts but you would like to keep a particular USB device exclusive to only one account.

Note: USB device isolation was tested with cameras, printers, scanners, hard drives, 3D mouses, sound cards and other devices. USB device isolation is supported by Windows 8 and newer and by all Windows Server versions.