It leads to glomerulonephritis, kidney disease, and hearing loss. It is an X-linked dominant disorder and involves many gene mutations. Mainly, the genes present on the X chromosome get mutated and hence, get passed on from one generation to another. The mode of inheritance of Alport’s syndrome depends on the X chromosome consisting of mutated genes. It either gets inherited from the mother or the father. Certain genes including the COL4A3, COL4A4, and COL4A5 play an important role in the biosynthesis of collagen. Mutations in any of these genes alter its production. Typically, the collagen associated with the glomerulus gets affected. The type IV collagen is important in the basement membrane in the kidneys, lung alveoli, inner ear, and eye. Majority of the mutations occur in COLA5 gene leading to Alport syndrome. In case of more than one gene mutation on the same autosome, it becomes an autosomal recessive disorder.