The political nonprofit aligned with House Speaker Paul Ryan is planning an advertising blitz to counteract a potentially bad score for the Republican healthcare bill from the Congressional Budget Office.

American Action Network on Tuesday announced a $2 million ad campaign in 21 House districts and national television, timed to coincide with Wednesday's expected release of the CBO analysis of the American Health Care Act, which passed the House on May 4.

"The ad features Elizabeth Jacinto, a mother of four who shared her health care story in one of AAN's issue advocacy campaigns earlier this year. Under the Affordable Care Act, Elizabeth lost both her doctor and health insurance – despite promises to the contrary. Now, with the passage of the AHCA, Elizabeth is looking forward to what the new plan means for her family, including more choices, lower costs, and better coverage," AAN said in a press release.

The original version of the bill received an initial score that predicted fewer people would be covered by partially repealing Obamacare, contributing to the problems GOP leaders and President Trump had in moving it to the Senate. The first CBO score also delivered projections of cost savings that Republicans found unacceptable.

Republicans are confident that the changes they made to the AHCA will fix the cost problem, at least. The new CBO score could heavily influence the debate in the Senate to craft an Obamacare replacement bill, and exactly how much of the House package is retained.

Districts targeted in the ad include several the Democrats are targeting in 2018, including Rep. Martha McSally of Arizona; California Reps. Jeff Denham, David Valadao, Kevin McCarthy, Steve Knight, Ed Royce and Darrell Issa; Florida Reps. Brian Mast and Carlos Curbelo; Rep. Rod Blum of Iowa; Illinois Reps. Peter Roskam and Rodney Davis; Rep. Kevin Yoder of Kansas; Rep. Bruce Poliquin of Maine; Minnesota Reps. Jason Lewis and Eric Paulsen; Rep. Don Bacon of Nebraska; Ohio Reps. Jim Jordan and Pat Tiberi; and Rep. Greg Walden of Oregon.

The ad also is running in Ryan's Wisconsin district.