Free of major upsets thus far this season, college football could get wacky in Week 3 when we least expect it.

Surprising results is what makes this game great and there after several opportunities on Saturday that could spell trouble for a couple title contenders and others off to a fast start this fall.

For the first time this season, four of the nation's Top 6 teams will play on the road — all as double-digit favorites — but not all matchups should be considered worrisome. Clemson is a four-touchdown favorite at Syracuse, a team that has played the Tigers tough (including a win) the last two years. But the Orange are coming into their prime-time showdown limping after a loss to Maryland and have seen inconsistent play thus far out of the quarterback spot.

Another elite power, Oklahoma, travels to UCLA, who's off to a disastrous start in Chip Kelly's second campaign. The Bruins have lost to Cincinnati and San Diego State and now face off with Heisman frontrunner Jalen Hurts and the red-hot Sooners offense.

There's as many as six Top 25 teams who could go down this week to unranked opponents in spots with upset potential written all over them.

Here are seven games worth taking a closer look at with favorites clearly on Upset Alert in Week 3. For this exercise to constitute an 'upset', the opening line must be at least a touchdown: