NRL's CEO Dave Smith has declared the code will consider stiff penalties for any fans found to be a part of last night's violent scenes at the Bulldogs v South Sydney match.

Two people have been charged with assault following the end to the match, which saw two other people taken to hospital including sideline official Darren Alchin who suffered a broken shoulder when he slipped over in an attempt to avoid a thrown water bottle.

One of the men charged with assault allegedly pushed an underage relative to the ground, causing facial injuries.

But Mr Smith said he was "disappointed" with yesterday’s events, which would not be tolerated in rugby league.

“These matters were serious and extremely disappointing for the entire game and do not reflect the game’s values both on and off-the-field,” he said.

“We will be working with the police, ANZ Stadium and the Bulldogs to carefully review all matters regarding fan behaviour.

“Under the game’s code of conduct, there are a range of sanctions available to consider, which we will do in a thorough and considered way.”

Earlier today, Canterbury Bulldogs CEO Raelene Castle said any members found to have contributed to the incident would be banned for life.

Around “eight to ten” Bulldogs fans were involved, she said.

“Unfortunately a handful of idiots ruined it for a crowd that was generally well-behaved and really enjoyed their evening,” she told TODAY co-host Cam Williams.

“Out of a crowd of 40,000 people, that’s a [small] number of absolute idiots and their behaviour was absolutely not acceptable in any way.”

Ms Castle echoed NRL Head of Football and former Bulldogs CEO Todd Greenberg’s calls for life bans for those involved.

There were heightened tensions at the rematch of last year’s grand-final between South Sydney and the Bulldogs.

Late in the game, referee Gerard Sutton infuriated Canterbury with a penalty against James Graham.

People were taken to hospital in the aftermath of the South Sydney-Bulldogs NRL clash. (9NEWS) (9NEWS)

The English prop, in trying to charge down Adam Reynolds' long-range field goal attempt, landed on the halfback's standing leg.

After alerting the official that Reynolds looked badly hurt, Sutton placed Graham on report and awarded a penalty directly in front of the posts.

Stand-in kicker Bryson Goodwin made no mistake to seal the two points.

Graham was animated in his criticism of the referee and Ms Castle admitted the club skipper had overstepped the mark.

“It’s not acceptable for our captain to get in the faces of officials on the field,” she said.

The violence inside the stadium spilled outside, with a 21-year-old man found by police after having been allegedly assaulted from behind as he left the ground.

Witnesses said he had been shoulder-barged by a stranger. The victim received a cut above his eye and was later released from hospital.

A 38-year-old man was arrested and charged with assault occasioning actual bodily harm.

The second man arrested was a 22-year-old accused of pushing an underage relative to the ground, causing minor facial injuries. It’s believed the young boy was attending the game with his parents. He did not require medical treatment.

Both men will face court later this month.

Police are also continuing the search for two men they say were identified as having thrown bottles from the stands.

NRL Head of Football Todd Greenberg said the organisation would also ban any members who participated in the violence for life.

"There are life bans available for us under the rules and we will work with the stadium, with the club and with the police to find those culprits," he said.

At the conclusion of the game, Bulldogs fans lined the stands and began throwing bottles – some full – towards referees and officials.

Referee Gavin Morris was struck and slipped over, but told 9NEWS he was not injured.

During the match, four people were ejected from the stadium.

The Bulldogs, who could now face sanctions from the NRL, said they would open an inquiry into the incident, which would include scouring images of the crowds for the culprits.

"I'll be having as much dialogue as is needed with the club, the stadium and the authorities to ensure appropriate penalties are handed out," Mr Greenberg said.

"There's a lot of marginal calls in Rugby League but the fan behaviour at today's game was completely unacceptable and we won't tolerate it.”