The CEO of one of Melbourne's busiest public hospital networks has resigned amid concerns about the service's performance.

On Monday, the recently appointed chair of the Northern Health Board, Jennifer Williams, announced that the Northern Hospital's Chief Executive Officer, Janet Compton, had resigned, effective immediately.

Janet Compton has resigned as CEO of Northern Health. Credit:Helen Grimaux

Ms Compton's resignation comes after the Epping hospital consistently failed some of the state government's key performance indicators during the year to March. It also follows investigations into bullying and concerns about patient care among plastic surgeons.

The state government's most recent hospital performance report revealed the Northern Hospital in Melbourne's booming northern suburbs has been struggling to meet targets for emergency and surgical care.