Hundreds of people have rallied in Brisbane's CBD in memory of teenager Tyrone Unsworth demanding the implementation of the Safe Schools program across Queensland schools.

Tyrone, 13, took his own life in October after years of homophobic bullying with the story of his torment making headlines.

On Sunday, a crowd featuring Tyrone's family and friends, pop star Jess Origliasso from the Veronicas and Multicultural Affairs Minister Grace Grace honoured the teenager's memory.

Tyrone's mother Amanda was scheduled to speak to the crowd but a family friend told AAP further online attacks against her son's memory had upset her too much to address the rally.

Organiser Jessica Payne told the crowd Tyrone's family wanted him to be remembered as a "hilarious, funny, beautiful person, full of spirit".

AAP

"Things have to change," Ms Payne said.

"We can't just hear more talk. We can't just let Tyrone be another person lost ... action has to be taken.

"The family has been so inspiring in this regard ... the very least we can do is stand with them in solidarity and fight."

Ms Grace, attending in place of Queensland employment minister Kate Jones, said Tyrone's death was a tragedy but she was hopeful his legacy would be a safer environment for all children.

Ms Jones admitted last month Queensland's community had failed Tyrone and work must be done to end bullying and discrimination of the LGBTI community from "the school yard to the workplace".

Facebook / Amanda Unsworth

Ms Jones said however it would be left to individual principals to decide if they wish to be part of the Safe Schools program.

Readers seeking support and information about suicide prevention can contact Lifeline on 13 11 14 and Suicide Call Back Service 1300 659 467.