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Hillary Rodham Clinton on Thursday addressed two hot-button topics in the liberal base of the Democratic Party: abortion rights and Wall Street regulation.

At a campaign event in Greenville, South Carolina, Clinton defended Planned Parenthood, which has faced recent criticism for a video made by anti-abortion activists that alleges the group’s clinics are illegally selling tissue from aborted fetuses for profit, a charge the group denies. Mrs. Clinton condemned the recent backlash as another effort to chip away at a woman’s right to a legal abortion.

Mrs. Clinton gave a more nuanced response when a voter asked whether she would reinstate Glass-Steagall, a banking regulation law passed during the Depression. President Bill Clinton successfully pressed Congress to repeal parts of the law in 1999, a move that led to the commingling of commercial and investment banking and that is widely criticized by liberals as contributing to the 2008 financial crisis.

“I think this is a much more complicated issue than to just point at any one piece of legislation and say ‘if we pass that, everything would be fine,’” Mrs. Clinton said. “I’m not interested in just saying there’s one answer to the too-big-to-fail problem.”

Instead, she proposed fully implementing the Dodd-Frank financial reform package, which she will talk about in more detail at a speech in New York on Friday.

“That’s where I part company with candidates on the other side of the aisle, all of whom want to either repeal it or, you know, stop enforcement of it,” she said of the Republican candidates’ positions on Dodd-Frank.

Mrs. Clinton also parts company with two of her Democratic Primary challengers, Senator Bernie Sanders of Vermont, and Martin O’Malley, a former governor of Maryland, on the topic of financial regulation. Both Mr. Sanders and Mr. O’Malley have both been vocal in their support of breaking up the big banks and reinstating Glass-Steagall.

For the first time, Mrs. Clinton weighed in on the controversy that has in recent weeks embroiled Planned Parenthood and roiled both sides of the abortion debate.

She called the video footage, which shows an official from the group discussing the price of providing fetal parts, the latest effort of a years-long “concerted attack” against “a woman’s right to choose.”

“Planned Parenthood has apologized for the insensitivity of the employee who was taped,” Mrs. Clinton said. “And they will continue to answer questions for Congress and others.”