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Belgium meet Chris Coleman's side at the Cardiff City Stadium on Friday night but Manchester United midfielder Fellaini will miss the top-of-the-table clash.

The two sides are on 11 points in Group B and the winner will take a huge step towards reaching next summer's finals.

Fellaini's late injury will come as a blow to Belgian boss Marc Wilmots, whose side are up to second in the latest FIFA rankings, as he scored twice in Sunday's impressive 4-3 friendly win over neighbours France.

Former Wales and Norwich striker Iwan Roberts believes a win for Wales would represent their finest hour in international football.

He said: "Belgium are second in the FIFA rankings and beating them in competition would be the biggest win in our history because of what it means.

"They have got some fantastic players and everybody expected them to run away with the group, not just be on top on goal difference at this stage of the campaign."