Bill Maher is ready to make personal sacrifices in order to make sure Donald Trump does not become the President of the United States… and he’s hoping others will do the same.

“New rule: From now until election day, everything else — every issue, every fight, every cause — has to take a backseat to defeating Trump. He’s like an infection — you don’t fool around with it,” he said on Friday’s Real Time. “We all have our issues that are important to us and so, just to lead by example, let me say that I will take my own, close-to-the-heart pet cause, pot legalization, off the table. And you know me: I have seeds in my urine.”

“If someone told me that pushing for pot might cost Hillary [Clinton] Ohio, until November 8th, I’m just going to shut the f—k up about it,” he added.

The topic came about because of recent headlines regarding transgendered bathrooms.

“There’s no room for boutique issues in an armageddon election,” Maher declared.

He continued, “I’m not suggesting that we throw the transgendered under the bus or discount their struggle — it can’t be easy finding panty hose when you’re 6’4″ — but this is exactly the kind of culture war issue that rousts a certain type of voter out of their trailers on Election Day.”

Watch the full clip above.

Real Time with Bill Maher airs Fridays at 10 p.m. on HBO.