Individuals with autism spectrum disorder (ASD) often have difficulty recognizing and interpreting how facial expressions convey various emotions – from joy to puzzlement, sadness to anger. This can make it difficult for an individual with ASD to successfully navigate social situations and empathize with others.

A study led by researchers at Children’s Hospital Los Angeles and Columbia University used functional magnetic resonance imaging (fMRI) to study the neural activity of different brain regions in participants with ASD, compared with typically developing (TD) participants, when viewing facial emotions.

The researchers found that while behavioral response to face-stimuli was comparable across groups, the corresponding neural activity between ASD and TD groups differed dramatically.

“Studying these similarities and differences may help us understand the origins of interpersonal emotional experience in people with ASD, and provide targets for intervention,” said principal investigator Bradley S. Peterson, MD, director of the Institute for the Developing Mind at Children’s Hospital Los Angeles. The results have been published online in advance of publication by the journal Human Brain Mapping.

While there is a general consensus that individuals with ASD are atypical in the way they process human faces and emotional expressions, researchers have not agreed on the underlying brain and behavioral mechanisms that determine such differences.

In order to more objectively look at how participants in both groups responded to a broad range of emotional faces, the study used fMRI to measure two neurophysiological systems, called valence and arousal, that underlie all emotional experiences. “Valence” refers to the degree to which an emotion is pleasant or unpleasant, positive or negative. “Arousal” in this model represents the degree to which an emotion is associated with high or low interest.

For example, a “happy” response might arise from a relatively intense activation of the neural system associated with positive valence and moderate activation of the neural system associated with positive arousal. Other emotional states would differ in their degree of activation of these valence and arousal systems.

“We believe this is the first study to examine the difference in neural activity in brain regions that process valence or arousal between typically developing individuals or those with ASD,” said Peterson, who is director of the Division of Child and Adolescent Psychiatry at Keck School of Medicine of USC.

To address this question, the researchers enrolled 51 individuals with ASD and 84 TD individuals. Each participant was shown a range of facial emotions in order to assess these two aspects of emotional experience, based first on their responses, both valence (is the emotion pleasant or unpleasant?) and arousal (degree of interest or attention).

The responses were then separately correlated with neural activity in order to identify systems related to valence and arousal. While the valence was remarkably similar between the two groups, the corresponding neural activity for arousal differed prominently.

There was much more neural activity in participants with ASD when they viewed arousing facial emotions, like happiness or fear. The TD individuals, on the other hand, more strongly activated attentional systems when viewing less arousing and more impassive expressions.

“Human beings imbue all experiences with emotional tone. It’s possible, though highly unlikely, that the arousal system is wired differently in individuals with ASD,” says Peterson. “More likely, the contrast in activation of their arousal system is determined by differences in how they are experiencing facial expressions. Their brain activity suggests that those with ASD are much more strongly affected by more arousing facial expressions than are their typically developing counterparts.”

The scientists concluded that the near absence of group differences for valence suggests that individuals with ASD are not atypical in all aspects of emotion processing. But the study suggests that TD individuals and those with ASD seem to find differing aspects of emotional stimuli to be relevant.

About this Autism research

Additional contributors include first author Angela Tseng, Zhishun Wang, Yuankai Huo and Suzanne Goh of Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute; and James A. Russell of Boston College.

Funding: The study was supported by the National Institute of Mental Health grants RO1 MH089582 and 5 T32 MH016434.

Source: Debra Kain – Children’s Hospital Los Angeles

Image Credit: The image is in the public domain

Original Research: Abstract for “Differences in neural activity when processing emotional arousal and valence in autism spectrum disorders” by Angela Tseng, Zhishun Wang, Yuankai Huo, Suzanne Goh, James A. Russell and Bradley S. Peterson in Human Brain Mapping. Published online November 3 2015 doi:10.1002/hbm.23041

Abstract

Differences in neural activity when processing emotional arousal and valence in autism spectrum disorders

Individuals with autism spectrum disorders (ASD) often have difficulty recognizing and interpreting facial expressions of emotion, which may impair their ability to navigate and communicate successfully in their social, interpersonal environments. Characterizing specific differences between individuals with ASD and their typically developing (TD) counterparts in the neural activity subserving their experience of emotional faces may provide distinct targets for ASD interventions. Thus we used functional magnetic resonance imaging (fMRI) and a parametric experimental design to identify brain regions in which neural activity correlated with ratings of arousal and valence for a broad range of emotional faces. Participants (51 ASD, 84 TD) were group-matched by age, sex, IQ, race, and socioeconomic status. Using task-related change in blood-oxygen-level-dependent (BOLD) fMRI signal as a measure, and covarying for age, sex, FSIQ, and ADOS scores, we detected significant differences across diagnostic groups in the neural activity subserving the dimension of arousal but not valence. BOLD-signal in TD participants correlated inversely with ratings of arousal in regions associated primarily with attentional functions, whereas BOLD-signal in ASD participants correlated positively with arousal ratings in regions commonly associated with impulse control and default-mode activity. Only minor differences were detected between groups in the BOLD signal correlates of valence ratings. Our findings provide unique insight into the emotional experiences of individuals with ASD. Although behavioral responses to face-stimuli were comparable across diagnostic groups, the corresponding neural activity for our ASD and TD groups differed dramatically. The near absence of group differences for valence correlates and the presence of strong group differences for arousal correlates suggest that individuals with ASD are not atypical in all aspects of emotion-processing. Studying these similarities and differences may help us to understand the origins of divergent interpersonal emotional experience in persons with ASD.

“Differences in neural activity when processing emotional arousal and valence in autism spectrum disorders” by Angela Tseng, Zhishun Wang, Yuankai Huo, Suzanne Goh, James A. Russell and Bradley S. Peterson in Human Brain Mapping. Published online November 3 2015 doi:10.1002/hbm.23041

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