And she is trying to sell multiple shows, including a children’s program for which she is writing a script. “You always hope for that magical phone call,” Ms. Micucci said, when I asked about her ambitions. “I hope that can happen — to be a lead in a TV comedy.”

“Right now,” she added, “I don’t know what my next big thing is.”

The future belongs to the women

That night, Ms. Micucci and Ms. Lindhome went to Bar Lubitsch, where they were scheduled to perform in a weekly comedy show called Jetpack. The early headliner was Bob Odenkirk, the star of the “Breaking Bad” spinoff “Better Call Saul.” He labored through a riff about being old and cranky, squeezing laughs from uneven material through the force of his delivery. “I’m trying to do a good show for you, but I will stop this show if my Ring video doorbell goes off,” he warned the audience.

Mr. Odenkirk seemed on the verge of escaping with a B-plus performance when a voice called out from the back. “I’ve been here all night, and you’re killing it,” said the voice. “Kiiiiiiiilllllling it.” It was Andy Dick, the comic who became an outcast in Hollywood after being accused of harassing, groping and exposing himself to people. For a moment, the air drained out of the room.

When Ms. Micucci and Ms. Lindhome took the stage, the audience seemed ready to move on from the 50-something white guys. Some of the night’s loudest laughter came during an edgy riff in their new song about the relentlessly mediocre office worker “Chris”: “If this was a marriage, he’d be the wife,” “If this was the apocalypse, he’d be a butter knife.” Jazz Ponce, a teacher who doubles as one of the show’s talent bookers, cackled uncontrollably.

The evening seemed to suggest something larger. Comedy can be a particular slog for the voicey feminist. Beyond the risk-averse executives and monochromatic writers’ rooms is the problem of the comics themselves: Any job that involves making crowds of strangers laugh will hold a special allure for damaged men.

And yet there are moments when you suspect the future belongs to the women.

“We haven’t performed in like a month; it felt so good to get back out there,” Ms. Lindhome said afterward.

“Maybe in the new year,” Ms. Micucci said, “we can book a couple more dates.”