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Five people have been shot dead after a "disgruntled" sacked employee went on a gun rampage at an RV motorhome business in Orlando, Florida.

Police have revealed the male shooter, 40, was sacked from Fiamma Incorporated in April and had returned to the business located on a busy industrial estate.

Orange County Sheriff's Office confirmed officers had attended a "workplace violence incident" three years ago involving the same person allegedly battering an employee.

Four males and one female were killed in the shooting spree at about 8am local time (1pm UK time) today.

The male shooter, 45, turned the gun on himself at the scene.

But the other seven people in the business survived the bloodshed, escaping uninjured.

(Image: WFTV)

Sheriff Jerry Demings said police arrived within two minutes of the 911 call at 8.03am local time to discover four dead victims plus the dead shooter.

The fifth victim died after being rushed to hospital.

"It's a sad day for us once again here in Orange County," he said.

"Our hearts and prayers go out to the families of the victims.

"The individual was armed with a handgun and a knife. There is no indication he used a knife on any of the vitims.

"He shot five innocent people this morning, then turned the gun on himself."

(Image: @fernandez_johny/Twitter)

A woman at the scene, Shelley Adams, told Orlando6 News that her sister, Sheila McIntyre, who works at Fiamma Inc, was in the bathroom when she heard gunshots.

Adams said her sister called her and kept repeating: "My boss is dead. My boss is dead."

Sheriff Demings said there was no suggestion this was terrorism related and instead appeared to be a case of workplace violence.

It had involved a "disgruntled employee" who had been fired recently, he added.

(Image: WFTV) (Image: WFTV)

Sheriff Demings revealed that police had been called to the business three years ago after the man had allegedly battered a colleague. He was not charged.

"He is a former employee of this business," Sheriff Demings said.

"He was fired in April of this year.

"He was a disgruntled (former) employee who came back to this business."

(Image: WFTV)

The man had a "minor" criminal history including being charged with possession of marijuana, DUI and misdemeanor battery.

The premises are located on Forsyth Road - near the junction with Hanging Moss Road.

The FBI joint terrorism task force is at the scene.

The location is about 25 minutes from the scene of the Pulse Nightclub shooting a year ago next week (June 12) when 49 people were shot dead by a gunman.

The location is also unclear but is understood to be a warehouse on an industrial estate.

(Image: WFTV)

The specific address for the shooting is given as being on North Forsyth Road near Hanging Moss Road, northwest of Colonial Drive and State Road 417.

Police dogs have been spotted being used at the location.

Forsyth Road is closed from University and State Road 50, local media reports.