Andy Puzder withdrew from consideration for Labor secretary Wednesday as Republican Senate opposition to President Donald Trump's choice mounted.

The confirmation of the CKE Restaurants chief executive looked increasingly in peril in recent days amid concerns about his business record and personal issues. Puzder needed a majority of Senate votes to become Labor secretary, but reports indicated that at least four of the 52 GOP senators could vote against him.

Puzder's hearing before the Senate Health, Education, Labor and Pensions Committee was set for Thursday.

"After careful consideration and discussions with my family, I am withdrawing my nomination for Secretary of Labor. I am honored to have been considered by President Donald Trump to lead the Department of Labor and put America's workers and businesses back on a path to sustainable prosperity," Puzder said in a statement Wednesday. "

"While I won't be serving in the administration, I fully support the President and his highly qualified team."

Puzder's withdrawal deals yet another setback to Trump's administration, which on Monday saw the resignation of National Security Advisor Michael Flynn. Trump and some Senate Republicans have already knocked Democrats for the slow pace of Cabinet confirmations, which the minority party insists is because of concerns about the nominees' qualifications and ethics paperwork.