Two people have died and 10 others are injured after a major crash involving seven vehicles on the Newell Highway near Dubbo on Tuesday.

Nine ambulances and three helicopters were called to the scene about 12.30pm, with reports multiple cars driving southbound had collided with two trucks.

A man and woman, both in their 20s, died at the scene, while others had to be cut free from the wreckages of their vehicles.

NSW Ambulance Superintendent Kathy Golledge said the crash scene was "absolute carnage".