15. NEO

Location: 2350 North Clark St.

Website: neo-chicago.com

Tucked behind a hidden door down a narrow alley, NEO is not only Chicago's oldest nightclub, it inspired Keanu Reeves's character's name in the Matrix movies. When you go, you'll see why. This club pumps goth, industrial, alternative, retro, electronic, house, new wave and everything in between, all set against a landscape of concrete, granite, mirrors, and lights. Be prepared to let loose and dance till dawn. Or till the machines come to take you away.