The world’s worst Ponzi schemer is hoping for a big break from President Trump.

Bernie Madoff has filed a petition for commutation of the 150-year prison sentence he’s serving for his epic, $65 billion fraud.

The clemency request is pending, according to the US Justice Department’s website.

It’s unclear whether Trump will consider Madoff’s application, according to CNBC, which first reported on the filing.

If granted, commutation would reduce the notorious crook’s sentence either totally or partially — and could eliminate the $170 billion in restitution he was ordered to pay following his 2009 guilty plea — but would not erase his conviction like a pardon.

The Justice Department website doesn’t show when Madoff filed his request, but the feds told CNBC that it typically takes one to three months for such records to appear online.

Madoff’s lawyer, Ira Lee Sorkin, had no information about Madoff’s filing, CNBC said.

Madoff, 81, is locked up in the medical center at the federal prison complex in Butner, North Carolina, according the federal Bureau of Prisons website.

In a 2014 email to CNBC, Madoff said he had suffered a heart attack and had Stage 4 kidney disease, but wasn’t receiving dialysis treatment.

In addition to the suffering inflicted on his victims, Madoff’s crimes took a devastating toll on his family, with older son Mark hanging himself in his Soho apartment in 2010, on the two-year anniversary of his father’s arrest.

The HBO movie “Wizard of Lies” suggested that Mark committed suicide after reading a Post report that authorities were considering charges against him, younger brother Andrew and their uncle, Peter Madoff.

Neither brother ultimately was charged, but Peter Madoff, Bernie’s younger brother, pleaded guilty to conspiracy and related charges in 2012 and was sentenced to 10 years in prison.

Andrew died of mantle-cell lymphoma in 2014, following a recurrence of the cancer that he blamed on stress and shame over his dad’s infamy.

“Even on my deathbed, I will never forgive him for what he did,” Andrew told People magazine a year earlier.

Two years ago, The Post found Madoff’s wife, Ruth, living in virtual exile in a rented townhouse in Old Greenwich, Connecticut, after Trump, in his pre-White House days, refused to rent her an apartment in any of his Manhattan buildings.