Three people have been killed and eight injured when a pickup truck fleeing Border Patrol agents at speeds topping 100mph hit a spike strip and rolled over in California near the Mexican border.

According to California Highway Patrol, the deadly crash took place in Campo at around 4.30pm Thursday on westbound Interstate 8 near Crestwood Road.

Officials say the incident began unfolding when Border Patrol agents patrolling the US-Mexico Border in East San Diego County noticed tire tracks headed north and a piece of a vehicle.

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This white Chevy Silverado carrying 11 people rolled over on westbound Interstate 8 in Campo, California, fleeing Border Patrol Thursday

A woman and two men were killed in the wreck, and eight others were injured

Debris is seen scattered on the roadway at the site of Thursday afternoon's crash

Another agent spotted a white Chevy Silverado, which was missing a part, and attempted to pull it over, according to NBC San Diego, but the driver refused to stop and sped away eastbound on Interstate 8 before turning around to the opposite direction.

Witnesses say the pickup was weaving through traffic and traveling at speeds of more than 100mph, reported Good Morning America.

Agents deployed a spike strip to stop the runaway vehicle before the pickup truck lost control and drove into an embankment, causing several passengers to be ejected.

CHP spokesman Officer Travis Garrow says a male driver and a female passenger were believed to be seated in the cab of the truck, and nine men were lying unrestrained in the bed.

Officials say the pickup truck was doing more than 100mph when Border Patrol agents deployed a spike strip to stop it

The driver, a US citizen, was taken into custody and then hospitalized with injuries

Several of the 11 people in the pickup truck were ejected onto the road because they were riding unrestrained

The driver, believed to be a US citizen, was the only one wearing a seat belt in the truck. He was taken into custody and transported to a hospital to be treated for injuries.

Officials have not released any personal information concerning the three fatalities, only saying that one of them was a woman.

Cal Fire San Diego tweeted that of the eight people who survived the crash, three were seriously injured and the other five sustained minor injuries.

The immigration statuses of the passengers in the wrecked Chevy were not immediately available.