A man is dead after a rollover crash on Highway 403 in Ancaster.

Two cars collided near on the highway west of Wilson Street around 11:30 p.m., after one vehicle is believed to have crossed over into oncoming traffic, according to Hamilton Paramedic superintendent Dave Thompson.

The man, who paramedics say was in his 50s, pronounced dead on scene.

A 27-year-old man and 26-year-old woman were also transported to hospital with serious injuries, but are expected to survive, said Thompson.

Photos from the scene show two heavily-damaged cars, with one resting on its roof and the other in the grassy median.

The highway was closed for several hours, but has since reopened.