An armed man has been arrested but his female accomplice remains on the run after an alleged botched burglary of a suspected cannabis grow house led to a stand-off with police in Melbourne's south-west.

The Wyndham Vale area is in lockdown and residents have been told to stay indoors as police search for the woman.

A man and a woman were spotted allegedly breaking into the suspected drug house on Brougham Avenue. They fled when police arrived.

The man ran to a house on Clitheroe Drive and hid in the roof cavity before surrendering to police.