BALTIMORE — Three innings into Wednesday night’s Yankee-Orioles game, there was a sense the next six frames would be worth watching.

How silly was that thinking? From the fourth to sixth inning, the Orioles displayed all the symptoms of a team that should be put to sleep by Major League Baseball.

Lefty John Means blanked the Yankees through three innings, but didn’t make it out of the fourth when the visitors scored four runs. Two more in the fifth set the Yankees up with a comfortable cushion, and five in the sixth led to a 14-2 whipping of the Orioles in front of an announced gathering of 16,299.

Led by two homers each from Gio Urshela and Kyle Higashioka, the Yankees slammed five homers and finished the three-game series with 16. That tied a major league record for a three-game series.

“It seemed like he set the tone for us and got us rolling,’’ Aaron Boone said of Urshela, who hit a two-run homer in the fifth and another two-run poke in the sixth after missing the previous two games after fouling pitches off each leg during the same at-bat Sunday night. “It is good to have him in there.’’

Higashioka’s first two-homer game in the big leagues produced five RBIs and earned him the game belt from his teammates. Cameron Maybin homered in the ninth and went 4-for-5 with two RBIs.

“I am getting more comfortable, less anxious at the plate, less anxious in the box,’’ said Higashioka, who has been splitting the catching duties with Austin Romine while Gary Sanchez has been on the injured list for the second time this season.

James Paxton was the beneficiary of the home run orgy and improved to 7-6 with his second straight victory. In 6 ²/₃ innings, his second longest outing of the season, the left-hander gave up a run, five hits and fanned seven.

“We can sure hit,’’ Paxton said. “Those guys, up and down the lineup, are swinging the bat well.’’

How well is hard to judge because the Orioles stink and the odor coming off them against the Yankees, especially at Camden Yards, is horrific.

The Yankees have won 15 straight at Camden Yards and are the second team to go 10-0 or better at a visiting ballpark since 1955. The five homers hiked the Yankees’ season total versus the O’s this year to 52, which is the major league record for homers against a single opponent.

Sixteen of those 52 homers were hit in these three games and Aaron Judge didn’t lose one ball, Gary Sanchez and Giancarlo Stanton are on the IL and Gleyber Torres, who destroys the Orioles at Camden Yards, didn’t play Wednesday after leaving Tuesday’s game early with an injury.

The 75-39 Yankees’ eighth straight win ties a season high and sent the them to Canada for a four-game series against the Blue Jays with a 10-game lead over the second-place Rays in the AL East.

With a pitching staff that would be in the middle of the Triple-A pack, the O’s lineup is their strength but the most excitement it caused Wednesday was in the fifth inning when Chris Davis had to be restrained from going after manager Brandon Hyde in the dugout.

Baltimore’s offensive output was Trey Mancini’s homer off Paxton in the fourth and Steve Wilkerson’s RBI double in the ninth off Chance Adams and they finished 0-for-4 with runners in scoring position.

Earlier in the day the Yankees got what they believed to be good news after tests done in New York on Torres kept him off the IL and the All-Star second baseman arrived from here in the eighth inning.

And no, Torres didn’t streak to the bat rack to get a hack at the slop coming from the Orioles’ pitchers. But who would have blamed him if he did?