Finding could help experts develop more effective treatments for depression

Functions in mood, regulation and motivation are likely to be the same

Institute discovered that the dorsal medial habenula controls the desire to exercise in mice

Ever struggle to stay motivated when planning a trip to the gym? Well, it way not be your fault - it may all be down to the way your brain's wired.



Scientists have pinpointed the region of the brain that is responsible for exercise motivation.

While the finding could one day lead to a way of encouraging people to be fit and healthy, researchers say it could also be used to create better treatments for depression.

Scientists have pinpointed the region of the brain that is responsible for exercise motivation, which many people struggle with and make excuses for dodging the gym (stock image). Experts from Seattle Children’s Research discovered that the dorsal medial habenula controls the desire to exercise in mice

Eric Turner and Yun-Wei Hsu, of Seattle Children’s Research Institute’s Centre for Integrative Brain Research, discovered that the dorsal medial habenula controls the desire to exercise in mice.

The structure of the habenula is similar in humans and rodents and these basic functions in mood regulation and motivation are likely to be the same across species, they explained.

The knowledge that such a specific area of the brain may be responsible for motivation to exercise could help researchers develop more targeted, effective treatments for depression.

Exercise is known to be the most effective non-pharmaceutical therapy for melancholy.



The structure of the habenula (illustrated) is similar in humans and rodents and these basic functions in mood regulation and motivation are likely to be the same across species, they explained

While the finding could one day lead to a way of encouraging people to be fit and healthy, researchers think it could be used to create better treatments for depression (illustrated in this stock image)

WHAT IS THE DORSAL MEDIAL HABENULA?

The dorsal media habenula is a tiny area of the brain that is responsible for exercise motivation. It has been found to control the desire to exercise in mice. The structure of the habenula is similar in humans and rodents. The knowledge that such a specific area of the brain may be responsible for motivation to exercise could help researchers develop more targeted, effective treatments for depression. Past studies have attributed many different functions to the habenula. A 2010 study revealed that the habenula plays a key role in helping animals survive in a world full of hidden rewards and dangers, by helping them make the best choices. It inhibits dopamine-releasing neurons when an animal fails to obtain a reward and is involved in behavioural responses to pain, stress, anxiety, sleep and reward. Dopamine is a neurotransmitter that helps control the brain's reward and pleasure centres. The habenula’s dysfunction is associated with depression, schizophrenia and psychosis. Advertisement

‘Changes in physical activity and the inability to enjoy rewarding or pleasurable experiences are two hallmarks of major depression,’ Dr Turner said.

‘But the brain pathways responsible for exercise motivation have not been well understood. Now, we can seek ways to manipulate activity within this specific area of the brain without impacting the rest of the brain’s activity.’

The research, published in the Journal of Neuroscience, used mice that were genetically engineered to block signals from the dorsal medial habenula.

Dr Turner's team collaborated with experts at the University of Washington to show that the genetically engineered mice were lethargic and ran far less than typical mice, which love to run in their exercise wheels.

The genetically engineered mice also lost their preference for drinking sugary water.

‘Without a functioning dorsal medial habenula, the mice became couch potatoes,’ Dr Turner said.

‘They were physically capable of running but appeared unmotivated to do it.’

In another group of mice, the team activated the dorsal medial habenula using laser technology called optogenetics.

The mice could choose to activate this area of the brain by turning one of two wheels with their paws.