WASHINGTON — A missile strike from an American military drone in a remote region of Yemen on Thursday was aimed at killing Anwar al-Awlaki, the radical American-born cleric believed to be hiding in the country, American officials said Friday.

The attack does not appear to have killed Mr. Awlaki, the officials said, but may have killed operatives of Al Qaeda’s affiliate in Yemen.

It was the first American strike in Yemen using a remotely piloted drone since 2002, when the C.I.A. struck a car carrying a group of suspected militants, including an American citizen, who were believed to have Qaeda ties. And the attack came just three days after American commandos invaded a compound in Abbottabad, Pakistan, and killed Osama bin Laden, the founder of Al Qaeda.