A medical evacuation plane has exploded in a ball of flames during take-off in the Philippine capital, killing all eight passengers and crew on board, officials say.

The Lion Air plane was bound from Manila to Haneda, Japan, and burst into flames at the end of the runway about 8pm local time, Manila’s main airport said.

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It’s reported the flight was carrying medical supplies the coronavirus crisis.

A medical evacuation plane has caught fire after taking off from Manila International Airport. Credit: REUTERS

Video footage showed a huge plume of smoke rising into the night sky as fire crews doused the fuselage with foam.

The twin-jet West Wind 24 was carrying three medical personnel, three flight crew, a patient and a companion, Richard Gordon, a senator and head of the Philippine Red Cross, said on Twitter.

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“Unfortunately, no passenger survived the accident,” the Manila International Airport Authority (MIAA) said in a statement.

An investigation by the Civil Aeronautics Authority of the Philippines was under way, MIAA said.