It's Ernest Rutherford's birthday today. Along with Michael Faraday, Rutherford was the greatest experimentalist in modern history and the twentieth century's experimental counterpart to Einstein. Rutherford stands out because he defies the traditional notion of genius. He was a gruff, plain spoken man with a booming voice who came from simple farming roots. He had little patience for philosophizing and even less for high-flying theorizing; he once said that "theorists play games with their symbols while we discover truths about the universe". And yet he had an eye for theoretical talent that allowed him to nurture Niels Bohr, as dyed-in-the-wool a theoretician and philosopher as you could find. When asked why he adored Bohr in spite of his general disdain for theoreticians, he famously quipped, "Bohr is different. He's a football player". A grateful Bohr held Rutherford in immense regard all his life and even named one of his sons after the master. Not just Bohr but many others benefited from Rutherford's tutelage; in a record that is unlikely to be ever topped, no fewer than 12 of his students and associates won Nobel Prizes.

As defining as these qualities were, to me Rutherford appears as a unique historical figure because in this age of Big Science and increasing complexity, he stands out as the undisputed master of the simple experiment. Throughout his career Rutherford made game-changing discoveries using equipment costing at best a few hundred dollars. The early twentieth century was an age of "string and sealing wax" physics and Rutherford harnessed this medium better than any other (Fermi came close). Whether he was bouncing alpha particles off nuclei, studying the disintegration of atoms or discovering radioactive transmutation, Rutherford's main goal was to illustrate deep physical principles in the simplest and most direct way possible.

It's not that he disdained fancy and expensive equipment; his students Ernest Walton, John Cockcroft and Piotr Kapitza did construct giant machines accelerating particles to high speeds and generating intense magnetic fields. But in his own work Rutherford exemplified the very ideal of the minimalist. An illustration was his beautiful discovery of radioactive transmutation on which he collaborated with his student Ernest Marsden. Marsden had observed that when he bombarded hydrogen atoms in a sealed box with a scintillation screen with alpha particles, he predictably observed hydrogen atoms striking the scintillation screen and setting off flashes. Things got more interesting when he realized that he could observe scintillations even when the box was emptied of hydrogen. This is when Rutherford took over. He realized that the goal was basically one of exclusion; if he could systematically exclude possible suspects that could react with the alpha particle and produce scintillations, he could determine the culprit. It was with this intent that he pumped the box with pure oxygen, carbon dioxide and dry air. Only in the last case did the scintillations double, indicating that there was something in the air that was producing hydrogens. After eliminating every source of contamination, Rutherford realized the revolutionary interpretation of the experiment; the alpha particles were interacting with the nitrogen in air to create oxygen and spit out hydrogen atoms. In one fell swoop Rutherford had realized the dream of alchemists, in spirit if not in every detail; he had literally changed one element into another. There were few other experiments in the history of science that demonstrated mankind's awesome intellect and mastery over nature.

Rutherford's students all stood upon his shoulders when it came to making deep discoveries about the universe using simple approaches. Other researchers also followed suit. The Davisson-Germer experiment, the discovery of nuclear fission and the Pound-Rebka experiment are but three instances of the triumph of simple, small science. Perhaps the most notable of all of Rutherford's disciples was James Chadwick who, in 1932, discovered the neutron. The husband-wife team of Joliot-Curies and other physicists from Germany had observed a penetrating radiation arising from beryllium when it was bombarded by alpha particles. Everyone assumed this radiation to be gamma particles. To prove otherwise, Chadwick used an ingenious and simple method in which he interposed screens at different distances from the source of the mysterious radiation to determine its range and direction. Then, knowing the energy of the incoming particles and the outgoing particles and using classical physics, he determined that the emanating particles must be neutral and must have masses equal to protons. The discovery of the neutron was a watershed in the history of science; since it led directly to nuclear fission and atomic bombs, in one sense it separated history into two stark periods.

Already the age of simple science was diminishing by the time Rutherford died in 1937. By then another Ernest - Ernest Lawrence - was well on his way toward constructing cyclotrons with increasing sizes and energies, a development that led to even bigger and more expensive particle accelerators after World War 2 and culminated in the discovery of the Higgs boson at the LHC last year. Big Science has arrived with a resounding bang, not just in physics but in other fields like molecular biology and astronomy. One wonders what Rutherford and his counterparts would have thought of these endeavors comprising thousands of scientists, a mind boggling array of instrumentation and the expenditure of billions of dollars. And you also have to ponder what the man who once said "If you need statistics to do science, then it's not science" would have had to say about particles like the Higgs whose existence hangs on the edge of five and six sigma tests of statistical significance rather than direct observation. He must of course have recognized that you cannot discovery everything there is to discover about nature using a two-man team and equipment built in your lab's machine shed, but he also would have disapproved of the general shift toward Big Science from small science in ways that biases funding agencies' and individual scientists' priorities.

Fortunately the age of simplicity is not dead. The 2010 Nobel Prize in physics went to physicists who discovered graphene using scotch tape. Discoveries in other disciplines like neuroscience are also being engineered using simple techniques; V. S. Ramachandran's work in determining important neural pathways is particularly notable in this regard. Going hand in hand with this kind of simple science is "amateur science", another endeavor which Rutherford would have approved of. Amateur astronomers have discovered extrasolar planets, amateur engineers have built computers and amateur DIY biologists are doing genetic engineering in their garages. In their own way these amateurs, using simple, inexpensive equipment bought off of eBay and pushing the boundaries of what's possible in garages and home labs, are keeping Rutherford's legacy alive. The man who revolutionized our understanding of the universe using little more than string and sealing wax would have watched with pride and hope.