Trends

Caenorhabditis elegans allows the investigation of numerous evolutionarily conserved fat and feeding regulatory mechanisms.

C. elegans studies have led to the deciphering of regulatory connections that were subsequently shown to function similarly in mammals, but also to findings that challenge certain paradigms of mammalian fat biology.

One difficulty in studying lipids in C. elegans is that there are currently no easy methods to unambiguously distinguish lipids in storage depots from those that are in lipoprotein-like yolk particles.

Both lipid synthesis and lipid breakdown pathways are activated in long-lived animals that lack their germlines and specific signaling lipids that promote activity of prolongevity pathways have been identified.

Levels of a specific tryptophan-derived metabolite underlie the incorporation of experience in feeding behavior.