Kathy Griffin continued her feud with Sarah Palin after the former Governor accused her of being a ‘has-been’ and a ‘bully’ over jokes the comedian made about Willow and Bristol Palin.

The 50-year-old feisty stand-up said: ‘If you think a comedian is a bully, what that tells me is you’ve never been bullied.’

She refused to rule out making jokes at Mrs Palin’s 16-year-old daughter’s expense, angry that the teenager used gay slurs on her Facebook.

At war: Kathy Griffin, left, and Sarah Palin latest feud started when Griffin said she would 'take down' Palin's daughter Willow for offensive comments she made

She told ABC's Nightline: ‘One time on her Facebook wall she used the f-word which is a pejorative term about gay people, not the swearing f-word which I enjoy, the other f-word which I don’t use.

‘The point is, when you’re 16 you know not to be using the f-word about gay people.’

She also responded to Mrs Palin’s comments that she was a ‘has-been comedienne’, responding: ‘I’m sorry, is this from the former Governor? She’s not the current Governor? She has-been the Governor? It’s interesting that she has-been.

When asked if she would like the politician to run for President in 2012 she said: ‘I really am praying for Sarah Palin to run for anything – local school commissioner, employee of the month at Dunkin Donuts – I don’t care what it is, I just want her to run for something.’

Angry: Griffin responded to comments she's a 'has-been comedienne' she called Palin a 'has-been Governor'

Mrs Griffin, who will play a Palin-esq character in TV show, Glee, after a run on Broadway in her own show, has previously attacked Mrs Palin's daughter Bristol, poking fun at her performance on Dancing with the Stars.

Last year, at a rally for U.S. troops Mrs Griffin said: 'She's the only contestant in the history of the show to actually gain weight.

'She gained like 30 pounds a week, I swear to God, it was fantastic. She's like the white Precious.'

The comments received a round of boos from the troops, with whom Mrs Palin is a popular figure.

Targets: Griffin has made jokes about Bristol, right, and Willow Palin, left. While their mother, Sarah, called on her to 'come up to Alaska and pick on me'

The latest spat kicked off when Mrs Palin told Fox News: 'Kathy Griffin can do anything to me or say anything about me, because you know, she's a 50-year-old adult bully is really what she is.

'She's kind of a has-been comedian and she can do those things to me.

'I would just ask for respect of my children.

'As she had stated on CNN that her New Year's resolution was to destroy my 16-year-old daughter, that takes it a little too far.

'Kathy, pick on me, come up to Alaska and pick on me, but leave my kids alone.'

Mrs Griffin responded on her Twitter page telling Mrs Palin: 'U made my day.'

She had previously told the Hollywood Reporter on January 1: ‘I've already gone for Sarah, Todd and Bristol obviously. But I think it's Willow's year to go down.’