A 33-year-old Melbourne man has died after suffering numerous fractures and burns to 50 per cent of his body in a fiery crash in the city's east on Wednesday.

Police are looking for four youths who drove a stolen black BMW four-wheel drive at high speed through a give way sign on Glenburnie Road in Mitcham on Wednesday afternoon and collided with a motorcycle.

The motorbike and driver were dragged up to 85 metres, before the bike became trapped underneath the car.

The four-wheel drive reversed and left the scene and the bike burst into flames.

"Friction has caused the motorcycle to catch fire and as a result the rider has also been burnt, significantly," Detective Inspector Stuart McGregor of the Major Collision Investigation Unit said.

The man died of his injuries in the Alfred Hospital and was identified as a Mitcham resident, who was a sheet metal worker.

Police are still trying to contact family overseas.

Detective Inspector McGregor said it appeared the four young people who stole the four-wheel drive behaved like they were playing a video game and "in real life people get hurt".

He warned the suspects would be arrested and "would go to jail".

The youths went on to steal a white Toyota Camry from a home in Scoresby. ( Supplied )

Police said the incident was connected to other crimes in Melbourne's south-east.

Investigators believe the group later abandoned the car in Scoresby before breaking into a home and stealing a white Toyota Camry.

That car was found burnt out overnight at Narre Warren, about 22 kilometres away.

"It's like they're playing a video game and unfortunately this is a real-life game and what happens is people get hurt," Detective Inspector McGregor said.

"What happens is people go to jail and that's going to be the result of this.

"Someone got hurt and these guys are going to go to jail.

"The fact is we're going to arrest you."

The motorcyclist remains in a critical condition in hospital. ( ABC News: James Hancock )

'United Nations of offending'

Deputy Commissioner Andrew Crisp told ABC Radio Melbourne investigators believed the group was responsible for a series of other crimes.

"We're throwing a lot of our resources at this and we certainly have some strong suspects," he said.

Deputy Commissioner Crisp described the crimes as "networked offending", rather than being the work of an organised gang.

They were similar to a wave of aggravated burglaries and violent carjackings last year, which prompted the Victorian Government to introduce new offences to deal with the issue.