1 Matt Ryan, Falcons vs. Buccaneers. The Buccaneers have been the worst fantasy defense against QBs this season and prior to their bye week, they allowed Mitchell Trubisky to score 55.46 points on them. With Matty Ice and the Falcons in desperate need of a win, expect him to bring his A-game. He should be able to put up a few TDs and establish himself as the top QB this week.

2 Patrick Mahomes II, Chiefs @ Patriots. Mahomes is coming off his worst outing so far, but he still passed for 313 yards and added a TD on the ground against one of the league's best defenses. This matchup with the Patriots should be an excellent Sunday night battle, but the Patriots will have a lot more trouble containing him than the Jaguars did.

3 Tom Brady, Patriots vs. Chiefs

4 Jared Goff, Rams @ Broncos. Goff is basically matchup-proof, and the Denver defense hasn't lived up to expectations anyway. The only glitch for Goff is that he might be without Brandin Cooks and Cooper Kupp as they deal with concussions. Even still, Goff should be able to put up solid numbers thanks to his other weaponry and he's posted at least 20 fantasy points in 4-of-5 games.

5 Kirk Cousins, Vikings vs. Cardinals. The Cardinals just allowed C.J. Beathard to throw for 349 yards and two TDs, so Goff should establish himself as a top option even with a makeshift receiving corps. Just imagine what Kirk Cousins, averaging 338 yards and 2.2 TDs per game, will be able to do against them.

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6 Aaron Rodgers, Packers vs. 49ers. Rodgers just had a massive 442-yard, three TD outburst against the Lions, but a lot of that came in garbage time. He just hasn't been himself this season as he continues to deal with the knee injury he suffered in Week 1. Realistically, you can never sit Rodgers, so he stays in the top-six with a favorable home matchup against the 49ers, who have allowed the seventh-most FPPG to QBs this year.

7 Ben Roethlisberger, Steelers @ Bengals. Starting Big Ben on the road is always a bit of a risk, but he should be able to put up quality numbers again. The Bengals give up the fifth-most FPPG to QBs and the Steelers defense is still bad, which means that Roethlisberger will need to continue to throw the ball. That's a recipe for success and makes him a top option for Week 6.

8 Carson Wentz, Eagles @ Giants. The Giants matchup may look favorable on paper, but with Wentz still not 100 percent and the Eagles on a short week on the road, he gets downgraded a bit. Also, it's worth noting that the Giants have held all but one QB to under 20.38 points this season, so Wentz may end up being a bit of a disappointment to his fantasy owners this week.

9 Deshaun Watson, Texans vs. Bills. Watson has posted at least 375 passing yards in three-straight games, and he's also been getting the job done with his legs this season (at least 36 rushing yards in every game this season). The biggest issue with him is that he hasn't scored a lot of TDs so far (just nine in five games). That may change against the Bills, who have allowed the 12th-most FPPG to QBs this season -- though they have done well to limit Kirk Cousins, Aaron Rodgers, and Marcus Mariota in consecutive weeks. Still, Watson has the weaponry and athletic ability needed to challenge the Bills defense, so he's a solid play.

10 Philip Rivers, Chargers @ Browns. Rivers continues to be remarkably consistent, recording at least 226 yards and multiple TDs in every game this year. The Browns have been up-and-down against QBs this season, but they recently allowed Derek Carr to post nearly 40 points against them. Rivers could find similar success and post one of his better outings of the year even on the road.

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11 Russell Wilson, Seahawks vs. Raiders (in London). Wilson hasn't been asked to do as much this season because of the Seahawks resurgent ground game, but he posted three TDs last week against the Rams and their strong defense. The Raiders have a weak stop-unit and have allowed QBs to account for 10 TDs this season. Wilson is one of the best they are facing so far this year, and with both teams playing in an unfamiliar setting, it could end up being an offensive showdown between the two west-coast teams.

12 Andy Dalton, Bengals vs. Steelers. Dalton is easily the best streaming matchup this week against a Steelers defense that allows the second-most FPPG to QBs. They have allowed Tyrod Taylor (25.58) and Ryan Fitzpatrick (31.14) to shred them, so Dalton figures to have a good chance to put up a few scores and continue building on his solid start to the season.

13 Cam Newton, Panthers @ Redskins

14 Andrew Luck, Colts @ Jets. In consecutive weeks, Luck has posted at least 365 yards and three TDs while being forced to throw the ball 121 total times in two games. That type of volume is unlikely to continue, but as long as his running game is virtually non-existent, he will be forced to shoulder the load. That gives him volume and upside, though the road matchup with the Jets defense could be tougher than most anticipate (Jets have allowed just seven TDs to QBs this season).

15 Derek Carr, Raiders vs. Seahawks (in London)

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16 Jameis Winston, Buccaneers @ Falcons. The Falcons defense has been fourth-worst against QBs this season, and they have allowed at least 27.6 fantasy points to each QB since Week 1. Winston is making his first start of the season, but he's surrounded by a lot of solid offensive weaponry and should be in good shape to perform well. He can be started as one of the top streamers in Week 6.

17 Mitchell Trubisky, Bears @ Dolphins. Trubisky put up a ridiculous 55.46 fantasy points last time on the field before the bye. Granted, that was against the Bucs, but the Dolphins are starting to decline after a strong start to the season. Trubisky can do damage through the air and with his legs and that makes him a fine starter if you need to replace a bye-week guy. Don't expect another 50-point outburst, but as a mid-tier QB2, he could be good.

18 Alex Smith, Redskins vs. Panthers

19 Baker Mayfield, Browns vs. Chargers. In two games as a starter, Mayfield has averaged 318.5 passing yards, 1.5 TDs, and 1.5 interceptions. Once he cuts down on his mistakes, he'll be more of a viable fantasy play. For now, he's just a middling option.

20 Marcus Mariota, Titans vs. Ravens. Mariota had a great outing against the Eagles and then completely regressed against the Bills. He's too inconsistent to trust -- especially against a very good Ravens defense.

21 Joe Flacco, Ravens @ Titans

22 Blake Bortles, Jaguars @ Cowboys. Will we get four TD Bortles or four pick Bortles this week? The world may never know. That said, the Cowboys have been middle-of-the-pack against QBs, but haven't allowed more than 24.78 points to any quarterback or more than two TDs. That caps Bortles' upside, as a lot of his value is TD-dependent.

23 Sam Darnold, Jets vs. Colts

24 Case Keenum, Broncos vs. Rams

25 Dak Prescott, Cowboys vs. Jaguars. Prescott has posted multiple scores just once this year. It's unlikely that will happen against the Jaguars.

26 Brock Osweiler, Dolphins vs. Bears

27 C.J. Beathard, 49ers @ Packers. Beathard has actually put up decent numbers in two starts this year, totaling 647 passing yards, five total scores, and four picks. Still, he's not very good and can't be trusted to consistently score non-garbage time TDs.

28 Josh Allen, Bills @ Texans. Allen had less than 100 passing yards against the Titans. He has mobility, but there's not enough here to trust him as a starting QB.

29 Josh Rosen, Cardinals @ Vikings