A Sydney man who ploughed into seven cyclists while driving in the south-eastern suburbs last year may withdraw his guilty pleas because the charges do not "fit the evidence", a court has heard.

And the man's barrister says his client "deeply regrets" the incident despite having "no knowledge or memory" of what happened.

The seven cyclists suffered multiple injuries ranging from minor abrasions to spinal fractures when Thomas Kerr, 28, ran into the back of their group as they rode along Southern Cross Drive, Eastlakes, on March 16.

All were taken to hospital and one is facing years of rehabilitation after losing function in her right hand.