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Flyers right wing Wayne Simmonds (right) scored his 28th goal and suffered a season-ending injury during Wednesday night's 4-1 win over Brad Richards (left) and the Chicago Blackhawks. (Eric Hartline | USA TODAY Sports)

PHILADELPHIA — A feel-good night for the Flyers, one that temporarily took away a little of the pain of a season that will end with no playoffs, ended with more anguish.

As much fun as it was for the Flyers to play well in a 4-1 win over Kimmo Timonen and the Chicago Blackhawks, they have to just be sick about the post-game medical news.

A little more than an hour after their victory, the Flyers tweeted that right wing Wayne Simmonds, their leading goal scorer, is done for the season with a lower-body injury.

Also, the Flyers announced that defenseman Andrew MacDonald suffered a season-ending upper-body injury.

It's believed Simmonds broke his left leg and MacDonald suffered a broken right hand.

Both injuries occurred late in the third period with the Flyers ahead 3-1.

MacDonald was hurt when he was struck in the hand by a puck just before Blackhawks captain Jonathan Toews was sent off for hooking 14:44 into the third.

With the Flyers on a power play, Simmonds was injured a few seconds later when he was in front of the Chicago net and struck in the left foot or leg on a shot from the point by Mark Streit.

Simmonds limped off right away, Michael Raffl replaced him on the power play and promptly scored for a 4-1 lead.

The Flyers issued no updates during post-game media availability.

The Flyers, who are nine points out of a playoff spot with seven games to play, now have had 17 players injured this season (not including Chris Pronger).

Through Wednesday, the Flyers have lost 286 man games to injuries (not including Pronger, their most since 440 in 2011-12.

Simmonds, who suffered a broken foot during the preseason but was ready for the season opener, is No. 17.

MacDonald missed 10 games with a broken foot from Oct. 25 to Nov. 19.

The Flyers, who have a day off on Thursday, likely will call up two players from the AHL's Lehigh Valley Phantoms for Friday's practice or Saturday's home game against the San Jose Sharks.

Brandon Manning likely will replace MacDonald on the roster to give the Flyers a seventh defenseman. The will need another blueliner just to have six for Saturday unless Luke Schenn, out the last two games with a lower-body injury, is ready to play.

The forward coming up to replace Simmonds likely will be either Scott Laughton, Petr Straka, Jason Akeson or Taylor Leier.

Simmonds' leg injury ends his season with 28 goals, one below his career-high of 29 that was set last season. His 28th was the opening goal on Wednesday.

Meantime, MacDonald's frustrating first full season as a Flyer is over.

Acquired in trade-deadline deal from the Islanders last season last March, MacDonald signed to a six-year, $30 million contract extension last April and was being counted on to play a lot of minutes this season.

Instead, MacDonald made the signing look bad by having a disappointing 2014-15 campaign, which included six healthy scratches as well as two injuries.

MacDonald finished his season with two goals, 12 points and a minus-5 in 58 games. His ice time this season was 20:01, down from 24:37 in 2013-14 over 82 games for the Islanders and Flyers.

Randy Miller may be reached at rmiller@njadvancemedia.com. Follow him on Twitter @RandyJMiller. Find NJ.com Philadelphia Sports on Facebook.