Conceived online after President Trump's inauguration and galvanized by the administration's handling of science issues, the march has gained a lot of steam in recent months. In February, some of the nation's biggest scientific organizations, including the American Association for the Advancement of Science, said they'd join in. Some 800,000 people have said online that they'll attend one of the events.

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Nye said Wednesday that he's never seen the scientific community so energized — or troubled by — political issues. Researchers are concerned by the president's proposed funding cuts to science agencies like the National Institutes of Health and the Environmental Protection Agency. And everyone should be alarmed by the Trump administration's skepticism of climate change, Nye said — “the most serious issue facing humankind.”

“Science is what makes our world what it is,” Nye said. “To have a movement or a tendency to set science aside is in no one’s best interest ... but nevertheless, that's what's happening in the U.S.”

Nye is the only bona fide celebrity of the three co-chairs. The 1990s TV icon, who has squared off against creationists and climate change deniers and is now CEO of the space advocacy group the Planetary Society, is exactly the kind of person you'd expect to headline a science march.

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Hanna-Attisha and Villa-Komaroff are giants in the public health and science communities but not necessarily household names.

The Flint pediatrician risked her career to alert officials to the dangerous levels of lead in her patients' blood. Her whistleblowing drew public attention to the crisis and led to an investigation of the city's water system. Time magazine named her one of its 100 most influential people in 2016, and her work garnered awards from environmental and social justice organizations.

In 1975, Villa-Komaroff became the third Mexican American woman to receive a science doctorate in the United States. Shortly after getting her PhD in the 1970s, she was part of the team of researchers who discovered that bacteria could be used to generate insulin — a vital medication for treating diabetes. She is a fierce advocate for diversity in science and a founder of SACNAS, the Society for Advancement of Chicanos/Hispanics and Native Americans in Science.

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These two co-chairs were consciously selected to address criticisms that the March for Science hasn't done enough to include women and minorities, who often face additional barriers working in scientific fields. The organizers — volunteers who are mostly new to political protest — have scrambled to address that and other concerns.

Some people say the march risks turning scientists into an interest group and are skeptical of explicit references to diversity. “Science sees no color” is a frequent refrain in online debates.

On the other hand, many contend that the march needs to be more aggressive in addressing inequality. An early organizer, University of Maine paleoecologist Jacquelyn Gill, quit the march's organizing committee over frustration with its leadership's handling of diversity issues. The diversity statement on the march website has gone through four revisions as organizers tried to keep up with criticisms.

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According to BuzzFeed, march organizers initially planned to announce Nye as the first co-chair last week, but held off after deciding it would look bad to name a white man as the event's first public face.

Adding Hanna-Attisha and Villa-Komaroff “was an opportunity to put up a picture of science that did not just fit the white male image,” organizer Stephani Page told BuzzFeed. Page was invited to join the march's steering committee in February after she faulted its handling of diversity.

March spokesman Aaron Huertas stressed that the work Hanna-Attisha and Villa-Komaroff have done is more important than their backgrounds. Both have devoted their careers to serving marginalized communities, and their research benefits people who might otherwise be left behind.

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“What happened in Flint is so illustrative of why we want and need a March for Science,” Huertas said, because it shows "what happens when scientific information is hidden from the public.”