This country needs a few good Republicans — one more would do — to rescue it from Betsy DeVos, one of President Trump’s worst cabinet choices and his pick to run the Department of Education.

The vote to confirm Ms. DeVos is expected as soon as Monday, and the Republican senators Lisa Murkowski of Alaska and Susan Collins of Maine now say they’ll vote against her, citing hundreds of calls they’ve received from furious voters. The result would be a tie that Vice President Mike Pence would break in Ms. DeVos’s favor. The extra Republican vote could come from one of several independent-minded senators; one candidate is Lamar Alexander, an expert on public schools who actually owes the country a good turn because of his failure as chairman of the committee vetting Ms. DeVos to question her closely and to give more time to her critics.

There are few more telling examples of Mr. Trump’s disdain for the federal government’s critical role in lifting up America’s schoolchildren than his choice of Ms. DeVos. She has spent years funneling her inherited fortune into a campaign to replace the nation’s traditional public schools with federally funded charter schools, regardless of the latter’s performance, and supporting vouchers, which help families send children to private or parochial schools and drain funds from public schools that need more, not less, support.

Mr. Alexander didn’t give senators much time to question Ms. DeVos, but it was sufficient to reveal her near-total unfamiliarity with public education law, standards and even problems. A conservative ideologue, she fell back on most policy questions to an assertion that states should make their own rules, even on settled matters of federal law, like access for handicapped children.