Two Republican senators said Wednesday that they won’t support President Trump’s nominee to lead the Environmental Protection Agency’s (EPA) chemical safety office.

The opposition from North Carolina Sens. Thom Tillis Thomas (Thom) Roland TillisTrump supporters chant 'Fill that seat' at North Carolina rally Momentum growing among Republicans for Supreme Court vote before Election Day Vulnerable GOP incumbents embrace filling Supreme Court seat this year MORE and Richard Burr Richard Mauze BurrRep. Mark Walker says he's been contacted about Liberty University vacancy Overnight Defense: Trump rejects major cut to military health care | Senate report says Trump campaign's Russia contacts posed 'grave' threat Senate report describes closer ties between 2016 Trump campaign, Russia MORE puts Michael Dourson’s nomination in danger. If one more Republican votes against him, he likely wouldn’t be confirmed to the post.

Even before Tillis’s and Burr’s opposition, Dourson was one of Trump’s most polarizing nominees. Democrats and environmentalists saw him as a lackey for the chemical industry who, for years, was paid to underplay the harms of various chemicals.

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The opposition from the North Carolina senators, first reported by the Wilmington, N.C., Star News, stems from a pair of major health controversies in the state surrounding water contamination at the Marine Corps Base Camp Lejeune and the recent discovery of the as-yet-unregulated chemical GenX in the Cape Fear River. The senators do not believe Dourson would be an effective force to protect the victims of those incidents.

“I will not be supporting the nomination of Michael Dourson. With his record and our state’s history of contamination at Camp Lejeune as well as the current Gen X water issues in Wilmington, I am not confident he is the best choice for our country,” Burr said in a statement.

“Over the last several weeks, Sen. Tillis has done his due diligence in reviewing Mr. Dourson’s body of work. Sen. Tillis still has serious concerns about his record and cannot support his nomination,” Tillis’s office said.

Dourson worked at the EPA until 1995. When he left, he started a nonprofit firm to evaluate chemical toxicity, often working for the chemical industry and making conclusions more industry-friendly than states, the EPA or universities.

In 2015, Dourson merged his firm into the University of Cincinnati, where he became part of the faculty, but did similar toxicology assessment work.

Democrats repeatedly hounded him on his history at a contentious hearing last month.

“You’re not just an outlier on this science, you’re outrageous in how far from the mainstream of science you actually are,” said Sen. Ed Markey Edward (Ed) John MarkeySchumer: 'Nothing is off the table' if GOP moves forward with Ginsburg replacement Democrats see fundraising spike following Ginsburg death Democratic senator calls for eliminating filibuster, expanding Supreme Court if GOP fills vacancy MORE (D-Mass.). Dourson has defended his work and committed to following sound science at the EPA.

After the hearing, EPA head Scott Pruitt Edward (Scott) Scott PruittJuan Williams: Swamp creature at the White House Science protections must be enforceable Conspicuous by their absence from the Republican Convention MORE hired Dourson as an adviser, bringing criticisms that he was circumventing the confirmation process.

Republicans have 52 seats in the Senate, compared to 48 in the Democratic caucus. If all remaining senators stay along party lines, Vice President Pence could break a 50-50 tie.

The Environment and Public Works Committee voted late last month along party lines in favor of Dourson.