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Oprah Winfrey isn't stupid ... she knows 50 Cent named his dog 'Oprah' to diss the talk show queen after a recent feud ... and when the two sat down together, she totally called him out on it.

"I heard you have a dog named Oprah ... that was not a compliment," she said to the rapper.

Fiddy sheepishly replied, "I love you ... you know how they say a dog is a man's best friend?"

During the confrontation, part of Oprah's new show, "Next Chapter," ... 50 explained how he felt Oprah's famous campaign against the N-word and degradation of women in hip hop felt like a personal attack.

"I would see moments where you would discuss your feelings on the culture, and everything that was wrong with the culture was on my CD ... and I was like, 'She doesn't like me.' "

So why name the dog Oprah? 50 told her O-ness, "At the time, I was just looking at the situation and I saw I was developing negative feelings for someone who doesn't even know me."

50 said he also got a cat ... and named it Gayle.

But now, the hatchet appears to be buried ... and 50 even told Oprah he pampers the hell out of the animals ... even hiring a babysitter to take care of them while he's out of town.