Three years into the Hudson River Derby, New York clearly has remained red. Upstart New York City FC have had the money, yet the old-guard Red Bulls have had the wins.

Nevertheless, NYCFC have a golden opportunity to change the narrative with a single win in their first elimination game with silverware implications: Wednesday’s U.S. Open Cup fourth-round showdown at Red Bull Arena (8 p.m., streaming online).

“Of course we’re growing up as a football club. It’s important for us to win the silverware,’’ said NYCFC coach Patrick Vieira, whose team was eliminated in the Cup by the Cosmos the past two years. “The Open Cup is one of the competitions we’re in, and we want to represent the fans, we want to represent the club really well. That’s why we have to perform. We have to give ourselves the best chance to win.

“We want to make this cup a little more spicy because the game’s against the Red Bulls. We know how important those games are for the fans and for the football club. We’re going to go there and try our best to win the game, of course.”

The rivalry has made up in spice what it lacks in history or competitiveness.

The Red Bulls, despite a frugal payroll dwarfed by big-spending NYCFC’s, are 5-1 with a plus-13 goal differential in the Derby, all so far played in the MLS regular season. Bradley Wright-Phillips (a team-high six goals this year) has personally outscored NYCFC 8-5 in the series, and his Red Bulls are 3-0 at home.

Vieira and counterpart Jesse Marsch got heated in the Red Bulls’ 4-1 home win last July 29, when Vieira said Marsch’s pregame comments influenced referee Mark Geiger. Vieira got dismissed from the sidelines by Geiger, and had a verbal confrontation with Marsch on his way off the field.

But on Wednesday it’s Marsch who is suspended, a result of being ejected in the Red Bulls’ fifth-round loss at Philadelphia last June 29.

This is NYCFC’s best team, third in the East at 7-5-3 with young Jack Harrison emerging to help star David Villa. The Red Bulls, meanwhile, are stuck in sixth at 6-7-2.

“[NYCFC] is a good team. I’ve heard them say things like, ‘This is the best team that they’ve had,’ and I agree with that,’’ said Marsch, who will give way to assistant Chris Armas. “It’s been an up-and-down year for every team, except maybe Toronto. But they’re good. They’ll miss some guys because of international break like us in some of the same positions. But it sets up for a great game, a game we’re really excited for. We know that we’ll get their best, and they know we’re going to give our best.”

NYCFC will be without forward Khiry Shelton (hamstring), defender Maxime Chanot (hamstring) is questionable and Yangel Herrera unlikely to play after a grueling run to the U-20 World Cup final with Venezuela. But they will get midfielder Andrea Pirlo (knee) back for the first time since May 17. The Red Bulls could get back defender Aurelien Collin (abdominal strain).