One of Victoria's largest suppliers of medical cannabis has been charged with serious trafficking offences, despite a push by federal and state governments to decriminalise the drug for those suffering from terminal illnesses and chronic pain.

Police raided the Carrum Downs home of Matthew and Elizabeth Pallett on May 20 and seized more than five kilograms of marijuana and derivative products, before charging the couple with possession, cultivation and trafficking offences.

Matthew and Elizabeth Pallett at home with their dog Champ. Credit:Joe Armao

The disabled pensioners have openly provided cannabis-based tinctures, chocolates and butters to about 80 regular clients, who suffer from medical conditions including multiple sclerosis, cancer, epilepsy and Crohn's disease.

"We only accept donations. And we only give it to people who show us a medical report confirming diagnosis with legitimate medical needs," Mr Pallett said.