Halton Regional Police are searching for two brothers in their 20s who disappeared mysteriously after working out at a Mississauga gym on Friday night.

Hamza Khan, 22, and Shahruka Khan, 20, went missing only hours after a family lunch at their Oakville home, their father, Mohammad Khan, told CBC News. They were last seen at a plaza in the Tenth Line and Thomas Street area around 9:15 p.m, where Khan says they met up with friends after working out.

Khan says the two men went to the gym together in one car. Police say they were driving a four-door silver, 2011 BMW car with the licence plate BWCJ918.

"We are praying for them to come back safe. Wherever they are, God keep them safe," an emotional Khan said Monday, adding they've never gone missing before.

"They never do this. If they go for a couple of hours from home or they go to the gym, they keep in touch ... It's the first time."

Cell phones last registered Friday, father says police told him

Khan said he and his family spent much of the weekend searching for the brothers, checking with local hospitals, scouring area roads for the car and visiting the plaza where he says their cell phone signals last registered.

They are two of seven children in the Khan family, their father said. Sharuka, a high school student, went to White Oaks Secondary School while Hamza was studying architecture at Sheridan College.

Khan says he doesn't believe the brothers have left the country, saying their passports remain at home.

Halton Police Staff Sgt. Ray Bruce wouldn't confirm to CBC News if any other agencies are involved in the search.

Police describe Hamza Khan as 6' 2", 140 lbs, slim build, black hair, and goatee and of Middle Eastern descent. They say he was possibly wearing black square-rimmed eye glasses, a black hooded winter jacket (with fur edging around the hood), along with a grey Adidas athletic top with the logo on the sleeve, dark sweat pants and Nike athletic running shoes.

Shahruka Khan is described as 5 '9", 165 lbs and medium build, with short black hair, and a goatee and of Middle Eastern descent. He was last seen wearing a black athletic pullover top with a zipper on the right shoulder area and dark sweatpants.

Khan says the family has tried repeatedly to call the brothers' cell phones to no avail.

"Everyday we're trying to call them."

Anyone with information on the whereabouts of the brothers is asked to contact the Halton Regional Police Service Communications Bureau at 905-825-4747, ext. 5155 or the on-duty Two District Staff Sergeant at 905-825-4747, ext. 2210.