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A day after 200 faculty members at the University of Southern California demanded that the university president, C.L. Max Nikias, step down, the Academic Senate officially called on him to resign, saying that “new leadership is in the best interest of the university now and going forward.”

Earlier Wednesday, the executive committee of the board of trustees announced plans to hire an independent lawyer and conduct a full investigation “into the misconduct and reporting failures that occurred at the U.S.C. student health center.”

The vote and investigation, which is likely to take months, come a week after U.S.C. officials said they should have acted more quickly to dismiss and report Dr. George Tyndall, who was the primary gynecologist at the student health center for decades.

An internal investigation had found that Dr. Tyndall performed pelvic exams inappropriately and made comments that amounted to sexual harassment, but university officials allowed the doctor to resign quietly with a payout, rather than report him to the medical board.