Due to the effects this drug has on the brain, along with our limitations in understanding how the brain actually works, certain vets advise against giving this drug to pets exhibiting signs of aggression, warning that the effect of alprazolam is just strong enough to rid these pets of the very anxiety that is holding back their aggressive outbursts.

Alprazolam should be given cautiously to pets with liver or kidney disease, glaucoma, pregnant, are elderly, or in a debilitated condition.

Taking alprazolam with antacids might slow the rate of absorption, and the two medications should be separated by at least two hours if being taken concurrently.

Drugs like cimetidine, erythromycin, itraconazole, ketoconazole, propranolol, or valproic acid might decrease the metabolism of alprazolam, and cause an increase in sedition.

Flumazenil might reverse the effects of alprazolam, making it useful in the event of an overdose.

The effects of digoxin might be increased if taking with alprazolam, and should be monitored.

In general, taking alprazolam with barbiturates or other CNS depressants might increase the sedative effects.

Hepatic enzyme inhibitors might alter the metabolism of other cytochrome P-450 metabolized drugs.