Not for the first time is "Millmania" threatening to sweep through the Australian Open, with a local crowd favourite progressing to the third round for the second occasion in his career.

Key points: John Millman has made the third round of the Australian Open for the first time since 2016 and will next play Roger Federer

John Millman has made the third round of the Australian Open for the first time since 2016 and will next play Roger Federer Jordan Thompson saved four match points in his five-set defeat to Italian 12th seed Fabio Fognini

Jordan Thompson saved four match points in his five-set defeat to Italian 12th seed Fabio Fognini Australian wildcard Marc Polmans tried hard but went down to Dusan Lajovic 6-2, 6-4, 6-3

The 30-year-old John Millman thrilled a vocal Melbourne Arena crowd with a 6-4, 7-5, 6-3 triumph over Polish 31st seed Hubert Hurkacz to advance to the last 32 for the first time in four years.

Day three results (men's draw) Novak Djokovic (SRB, 2) def. Tatsuma Ito (JAP) 6-1, 6-4, 6-2

Novak Djokovic (SRB, 2) def. Tatsuma Ito (JAP) 6-1, 6-4, 6-2 Roger Federer (SUI, 3) def. Filip Krajinovic (SRB) 6-1, 6-4, 6-1

Roger Federer (SUI, 3) def. Filip Krajinovic (SRB) 6-1, 6-4, 6-1 Stefanos Tsitsipas (GRE, 6) def. Philipp Kohlschreiber (GER) W/O

Stefanos Tsitsipas (GRE, 6) def. Philipp Kohlschreiber (GER) W/O Tennys Sandgren (USA) def. Matteo Berrettini (ITA, 8) 7-6 (9/7), 6-4, 4-6, 2-6, 7-5

Tennys Sandgren (USA) def. Matteo Berrettini (ITA, 8) 7-6 (9/7), 6-4, 4-6, 2-6, 7-5 Roberto Bautista Agut (ESP, 9) def. Michael Mmoh 5-7, 6-2, 6-4, 6-1

Roberto Bautista Agut (ESP, 9) def. Michael Mmoh 5-7, 6-2, 6-4, 6-1 Diego Schwartzman (ARG, 14) def. Alejandro Davidovich Fokina (ESP) 6-1, 6-4, 6-2

Diego Schwartzman (ARG, 14) def. Alejandro Davidovich Fokina (ESP) 6-1, 6-4, 6-2 Tommy Paul (USA) def. Grigor Dimitrov (BUL, 18) 6-4, 7-6 (8/6), 3-6, 6-7 (3/7), 7-6 (10/3)

Tommy Paul (USA) def. Grigor Dimitrov (BUL, 18) 6-4, 7-6 (8/6), 3-6, 6-7 (3/7), 7-6 (10/3) Marin Cilic (CRO) def. Benoit Paire (FRA, 21) 2-6, 7-6 (8/6), 6-3, 1-6, 7-6 (10/3)

Marin Cilic (CRO) def. Benoit Paire (FRA, 21) 2-6, 7-6 (8/6), 6-3, 1-6, 7-6 (10/3) Guido Pella (ARG, 22) def. Gregoire Barrere (FRA) 6-1, 6-4, 3-6, 6-3

Guido Pella (ARG, 22) def. Gregoire Barrere (FRA) 6-1, 6-4, 3-6, 6-3 Yoshihito Nishioka (JPN) def. Daniel Evans (GBR, 30) 6-4, 6-3, 6-4

Yoshihito Nishioka (JPN) def. Daniel Evans (GBR, 30) 6-4, 6-3, 6-4 Milos Raonic (CAN, 32) def. Cristian Garin (CHI) 6-3, 6-4, 6-2

Australian fans were unlucky not to see Millman joined in the third round by countryman Jordan Thompson, who came from two sets down and saved four match points before losing to 12th seed Fabio Fognini 7-6 (7/4), 6-1, 3-6, 4-6, 7-6 (10/4) in a classic encounter that finished beyond midnight in Melbourne.

Millman now faces the daunting task of trying to take down 20-time major winner Roger Federer in the third round, although he has reason to back his chances, considering he beat the Swiss in four sets at the 2018 US Open.

Millman spoke only yesterday about how much he thrives on the raucous support of his fans when he plays at the Australian Open, and he even joked he did not mind when they had a few drinks under their belt.

The Queenslander gave the spectators what they came for tonight, with another gutsy performance built on his never-say-die attitude.

He won the first set despite having his serve broken twice, as the pressure he built on the Hurkacz serve was enough to secure three breaks of his own.

The second was almost identical to the first, with breaks of serve exchanged, and as the crowd chanted "Johnny, Johnny!" at the conclusion of the set, Hurkacz's spirit seemed to be crushed.

With Millman leading 5-2 in the third set, the Pole did not endear himself to the crowd when he requested the stadium roof be fully closed because of some spots of rain, causing a delay and requiring a number of ball kids to mop up the court surface with towels.

The brief halt to proceedings did little to rattle Millman, however, who used his next service game to clinch victory, before he accepted the wild applause of the crowd and even had time to pose for selfies.

"I love a vocal crowd," Millman told his media conference.

"Obviously the matches I played — probably two really special courts, Show Court Three and Melbourne Arena — are notorious for the crowd support you get there, the vocal Aussies.

"I think the people who know me know that I'm just your typical Aussie bloke. So I'm one of the people."

Thompson falls just short

Thompson appeared set for an early night when he trailed Fognini by two sets to love on Margaret Court Arena.

But the 25-year-old dug deep and with Australian Davis Cup captain Lleyton Hewitt watching on, he fought his way back into the contest to force a deciding set.

Jordan Thompson saved four match points before Fabio Fognini claimed victory. ( AAP: Scott Barbour )

At 5-4 and with Thompson serving, Fognini earned two match points but each was saved by his fiery opponent, who was feeding off the energy of the boisterous late-night crowd.

Thompson faced another two match points when Fognini led 6-5, both of which were saved, but when the match entered a fifth-set "super tiebreaker" it proved a bridge too far for the local hope.

Fognini crunched a clean backhand winner to claim the match after four hours and five minutes on court, before tossing his racquet in the air as relief and joy set in for the well-travelled Italian, who has now won consecutive five-set matches.

The second-round finish equalled Thompson's best showing at the Open.

Polman gallant in defeat

Local wildcard Marc Polmans has been unable to repeat his heroics from the first round, having exited the tournament in straight sets at the hands of Serbian Dusan Lajovic.

Polmans was forced to back up just over 24 hours after beating Mikhail Kukushkin in five sets in the first round and he found Lajovic a class above as an opponent, with the 24th seed victorious 6-2, 6-4, 6-3 on court three at Melbourne Park.

Marc Polmans reached the second round of the Australian Open for the first time in his career. ( AAP: Natasha Morello )

Lajovic, who reached the final of the Monte Carlo Masters last year, burst out of the blocks to comfortably win the first set, and a single break was enough to secure the second and establish a two-sets-to-love lead.

A break of the Polman serve in the fifth game of the third set sent Lajovic on his way to victory and he will play 14th seed Diego Schwartzman in the third round.

Fatigue was an issue for both players, with Lajovic's first-round match against Kyle Edmund beginning on Monday, before being postponed until Tuesday because of the lengthy rain delay on day one.

Polmans did not get on the court at all on the opening day and when he finally did he needed four hours and 17 minutes to get past the plucky Kukushkin out on court seven.

But the 22-year-old lost no admirers in going down to Lajovic, whose crisp single-handed backhands proved too good for his younger opponent on several occasions. He also posted 12 aces and did not drop serve once.

Polmans, who was playing only his third match at a major, should enjoy a rankings spike up from his current standing of 133.