We thank members of the Segal group and the Center for Studies in Physics and Biology for discussions. E.S. is supported by grants from the European Research Council and the Israel Science Foundation. D.Z. is supported by the James S. McDonnell Foundation and the Dan David Prize Scholarship. D.Z. and T.K. were partly supported by the Israeli Ministry of Science and Technology. Lifelines DEEP was funded by: ERC-2012-322698 and NWO-SPI-92-266 to C.W.; ERC-715772 and NWO-178.056 to A.Z.; NWO-864.13.013 and CVON-2012-03 to J.F.

Reviewer information

Nature thanks Ami Bhatt, Julie Segre and the other anonymous reviewer(s) for their contribution to the peer review of this work.