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Chile's northern coast has been hit by more than 300 earthquakes in the past week in what seismologists warned Tuesday could be the precursor to a long-overdue disaster.

Most of these quakes have been too small to be felt on land, but people living near the city of Iquique have experienced the rumbling of up to a dozen tremors per day.

Experts analyzing this flood of data are worried the increased seismic activity could be a sign the region is about to experience its first devastating quake in 137 years. The last event, a magnitude-8.5 quake in 1877, killed thousands of people and created a deadly tsunami that reached Hawaii and Japan.

"It is very unusual activity and we are trying to find out what is causing it," said Mario Pardo, deputy head of the seismology center at the University of Chile.

A screenshot of a United States Geological Survey (USGS) map showing earthquakes in the past seven days stronger than magnitude-4.5 off the northern coast of Chile. USGS

"We usually get around 10 earthquakes per day in this area [many of them very small], but now we have been getting up to 100 per day," he told NBC News via telephone from the country's capital Tuesday.

Pardo told NBC News that seismologists are particularly concerned about this cluster of quakes because press reports following the 1877 event said there was a similar "swarm" of tremors beforehand.

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"We have been waiting for a big one in this area for some time - this is a place where we are expecting an earthquake of over 8.5 magnitude," he said.

Paulina Gonzalez, an expert at the University of Santiago, backed up this analysis. "The latest string of quakes is noteworthy because the last one happened in this seismic zone more than 130 years ago. It's a zone where quakes should happen more often, and they haven’t in a very long time," she told The Associated Press.

"A big earthquake could strike in a number of years or it could strike sooner - the only thing we can be certain of is that it will strike."

The United States Geological Survey (USGS) said its own analysis showed that in the past seven days there had been 41 quakes in the area stronger than magnitude 4.5.

Janan Purstey, a geophysicist at the National Earthquake Information Center, part of the USGS in Denver, said seismologists in Chile would be better placed than anyone to assess the threat of the current activity.

Chile is one of the world's most earthquake-prone countries, with its 2,500-mile coastline tracing where the Nazca tectonic plate meets the South American plate.

In 1960 it was hit by the largest earthquake ever recorded: The Valdivia earthquake, also known as the Great Chilean Earthquake, was a catastrophic magnitude-9.5 event that killed up to 6,000 people and created an 80-foot tsunami that reached as far as Hong Kong.

Men and women on a main street in Concepcion, Chile, look up toward building tops as an earthquake hits the country on May 21, 1960. ALEJANDRO MORENA ASEGURA / AP, file

But this, along with a magnitude-8.8 earthquake in 2010, hit much farther south than the region affected by the current cluster. The major worry for northern Chile is that the 1877 quake created what is known as a seismic gap - a fault line likely to produce earthquakes because it has been quiet for some time.

The recent northern flurry began on March 16 with a magnitude-6.7 tremor off of Iquique, home to 180,000 people. People living in low-lying areas evacuated their homes to higher ground (shown in the full-bleed image above) but no tsunami materialized.

Since then, Pardo and his peers have seen the needles on their seismographs barely take a rest. They are still unsure of what it means, but they have given a series of hypothetical situations to state and government officials.

"We are working with all our authorities and they now have immediate access to our information in real time," he said. "We just want to make sure people are prepared."

"A big earthquake could strike in a number of years or it could strike sooner," he added. "The only thing we can be certain of is that it will strike."

The Associated Press contributed to this report.