Once, he was the “Most Interesting Man in the World.” Now, he’s just a man.

So it goes for Jonathan Goldsmith, 77, the actor who played the smooth-talking, silver-bearded pitchman for Dos Equis, the Mexican beer. Mr. Goldsmith, who took the role in 2006, now joins the ranks of those who once stood for something — Old Spice, PCs, Macs, Dells, Men’s Warehouse, Subway — but have since been cut off from their fans and television face time, deposed and brandless.

Many pitchmen and women live out their tenure with dignity, and go on to other things, as Mr. Goldsmith is likely to do. Others have rockier endings. Here are some of the more notable spokesmen and spokeswomen who have since moved on.