The Senate confirmed CIA Director Mike Pompeo Michael (Mike) Richard PompeoOvernight Defense: Pentagon redirects pandemic funding to defense contractors | US planning for full Afghanistan withdrawal by May | Anti-Trump GOP group puts ads in military papers Overnight Defense: House Democrats unveil stopgap spending measure to GOP opposition | Bill includes .6B for new subs | Trump issues Iran sanctions after world shrugs at US action at UN Navalny calls on Russia to return clothes he was wearing when he fell ill MORE to be secretary of State on Thursday, overcoming steep opposition to his nomination.

Senators voted 57-42, well over the simple majority needed for approval by the chamber.

Pompeo’s confirmation was a virtual lock after Sen. Rand Paul Randal (Rand) Howard PaulSecond GOP senator to quarantine after exposure to coronavirus GOP senator to quarantine after coronavirus exposure The Hill's Morning Report - Sponsored by National Industries for the Blind - Trump seeks to flip 'Rage' narrative; Dems block COVID-19 bill MORE (R-Ky.) reversed his position and said he would support Trump’s pick.

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The announcement came amid an intense pressure campaign by the White House and spared Pompeo the dubious distinction of being the first secretary of State nominee since at least 1925 to fail to win over the Senate Foreign Relations Committee.

“After calling continuously for weeks for Director Pompeo to support President Trump Donald John TrumpOmar fires back at Trump over rally remarks: 'This is my country' Pelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Trump mocks Biden appearance, mask use ahead of first debate MORE’s belief that the Iraq war was a mistake, and that it is time to leave Afghanistan, today I received confirmation that Director Pompeo agrees with President Trump,” Rand said explaining his decision.

But Pompeo’s nomination faced historic opposition from Democrats, sparking an unusually partisan confirmation fight for a secretary of State nomination.

"In his role at the CIA, Mr. Pompeo has demonstrated the ability to be an effective manager and operator on the world stage," Jones said in a statement explaining his decision to back Pompeo.

But that’s substantially less than the 14 Democrats plus King, who caucuses with the Democrats, who supported Pompeo last year to be CIA director.

Pompeo is poised to come close to a record on opposition votes received by a secretary of State nominee. That record is currently held by Trump’s first secretary of State, Rex Tillerson Rex Wayne TillersonGary Cohn: 'I haven't made up my mind' on vote for president in November Kushner says 'Alice in Wonderland' describes Trump presidency: Woodward book Conspicuous by their absence from the Republican Convention MORE, who was confirmed 56-43 last year.

Senate Minority Leader Charles Schumer Chuck SchumerSenate Democrats introduce legislation to probe politicization of pandemic response Schumer interrupted during live briefing by heckler: 'Stop lying to the people' Jacobin editor: Primarying Schumer would force him to fight Trump's SCOTUS nominee MORE (D-N.Y.), who supported Pompeo to be CIA director, said this week that he would oppose him, in part, because of the investigation into Russian meddling in the presidential election.

Schumer told reporters that he asked Pompeo if he would publicly urge Trump not to fire special counsel Robert Mueller Robert (Bob) MuellerCNN's Toobin warns McCabe is in 'perilous condition' with emboldened Trump CNN anchor rips Trump over Stone while evoking Clinton-Lynch tarmac meeting The Hill's 12:30 Report: New Hampshire fallout MORE or Deputy Attorney General Rod Rosenstein Rod RosensteinDOJ kept investigators from completing probe of Trump ties to Russia: report Five takeaways from final Senate Intel Russia report FBI officials hid copies of Russia probe documents fearing Trump interference: book MORE, but Pompeo “demurred.”

Pompeo, according to Schumer, also refused to walk back some of Trump's "nasty comments" about American Muslims or individuals from South Asia.

"I am voting 'no' for those reasons, and I think people have good reasons to vote 'no' for Secretary Pompeo, both on the foreign policy sphere, and in these areas," Schumer added

Pompeo’s confirmation was a setback for liberals, who wanted to force Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellPelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Senate GOP aims to confirm Trump court pick by Oct. 29: report Trump argues full Supreme Court needed to settle potential election disputes MORE (R-Ky.) to try to discharge Pompeo’s nomination from the committee. The unusual move would have required 60 votes and given Democrats an opening to try block Pompeo — the first time they would have been able to scuttle a Trump nominee on the Senate floor.

But that strategy failed to take hold as vulnerable Democrats began coming out in support of Pompeo's nomination.

Red-state Democrats faced intense pressure from both sides, with progressive groups urging them to block Trump’s “war cabinet” and conservatives arguing opposition was a sign they were too liberal for their home states.

“So, what are red state Dems to do? Placate the base to pass the liberal Kamala Harris Kamala HarrisButtigieg stands in as Pence for Harris's debate practice First presidential debate to cover coronavirus, Supreme Court Harris joins women's voter mobilization event also featuring Pelosi, Gloria Steinem, Jane Fonda MORE litmus test? Or vote to confirm Pompeo? Either way red state Dems are left in a no-win situation,” Katie Martin, a spokeswoman for the National Republican Senatorial Committee (NRSC), said ahead of the vote.

Democratic Sens. Jon Tester Jonathan (Jon) TesterPence seeks to boost Daines in critical Montana Senate race This World Suicide Prevention Day, let's recommit to protecting the lives of our veterans Filibuster fight looms if Democrats retake Senate MORE (Mont.), Debbie Stabenow Deborah (Debbie) Ann StabenowOVERNIGHT ENERGY: Trump rollbacks could add 1.8 billion tons of greenhouse gas emissions over 15 years: analysis | Intensifying natural disasters do little to move needle on climate efforts | Experts warn wildfire smoke could worsen COVID-19 GAO report finds brokers offered false info on coverage for pre-existing conditions Democrats back away from quick reversal of Trump tax cuts MORE (Mich.) and Bob Casey Robert (Bob) Patrick CaseySecond GOP senator to quarantine after exposure to coronavirus GAO report finds brokers offered false info on coverage for pre-existing conditions Catholic group launches .7M campaign against Biden targeting swing-state voters MORE Jr. (Pa.) were among the red and purple state senators who opposed Pompeo. Sen. Mark Warner Mark Robert WarnerIntelligence chief says Congress will get some in-person election security briefings Overnight Defense: Trump hosts Israel, UAE, Bahrain for historic signing l Air Force reveals it secretly built and flew new fighter jet l Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' House approves bill to secure internet-connected federal devices against cyber threats MORE (D-Va.), who isn't up for reelection but supported Pompeo to be CIA director, announced his opposition moments before the vote.

But Republicans lashed out at Democrats throughout the week. Sen. Cory Gardner Cory Scott GardnerOvernight Health Care: US coronavirus deaths hit 200,000 | Ginsburg's death puts future of ObamaCare at risk | Federal panel delays vote on initial COVID-19 vaccine distribution The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Senate GOP sees early Supreme Court vote as political booster shot MORE (R-Colo.), the chairman of the NRSC, accused Democrats of “procedural sabotage.”

McConnell on Thursday called the Democratic tactics a failed attempt to “play politics.”

“It’s just too bad Director Pompeo’s confirmation process has offered such a prime example of the historic partisan obstruction that my colleagues across the aisle are visiting on the Senate,” he said.