New road safety initiatives will be fast-tracked after a devastating 24 hours on Victorian roads, with five people killed in separate accidents.

Key points: Victorian road toll at 204, compared with 171 at the same time in 2015

Victorian road toll at 204, compared with 171 at the same time in 2015 TAC to put new short-term measures in place

TAC to put new short-term measures in place Five die on Victorian roads in 24 hours

Three motorcyclists died and two drivers were killed in Melbourne and in Victoria's north-west in the past 24 hours.

The deaths bring the state's road toll to 204, compared with 171 at the same time last year.

Transport Accident Commission (TAC) chief executive Joe Calafiore said motorcycle fatalities so far this year were already twice the previous year's toll.

"What we are going to be looking at is between now and Christmas, what shorter term initiatives can be pulled forward to see what we can do to accelerate some reductions in road trauma," he said.

"We can be doing so much better than we are doing right now."

Mr Calafiore said it was unacceptable for the road toll to be so high.

"We've had a horrific 24 hours and to be honest we've had a horrific year," he said.

"The levels of road trauma in Victoria now are simply unacceptably too high

Roads Minister Luke Donnellan said people need to be more responsible on the roads.

"We can provide better infrastructure, but if people aren't making the right decisions, we can't cushion them from the effects of death or serious injury," he said.

Of the five deaths, a man died after losing control of his bike on the Calder Freeway near Keilor Park Drive in Melbourne's north-west just after 11:30pm on Friday.

It followed the death of a motorcyclist after a collision with a truck on Warrigal Road in Oakleigh, in Melbourne's south-east five hours earlier.

Another motorcycle fatality occurred in Coolaroo in the city's north earlier in the day.

Meanwhile, a 22-year-old woman died in a crash near Swan Hill in Victoria's north-west at 4:00pm on Friday and another female driver died at Narre Warren in Melbourne's south-east two hours earlier.