If that other borough can reinvent itself, why not the Bronx?

That is the premise behind the Bronx Beer Hall, which drew hundreds of people for its opening on Feb. 1. Consider it a cross-cultural experiment in a neighborhood of entrenched ethnicity: two brothers whose family hails from Puerto Rico selling craft beer made in the Bronx in the heart of its Little Italy.

“We knew we wanted to help change the perception of the borough we grew up in and love,” said Anthony Ramirez II, 34, one of the owners, in the days before the opening.

“We want to get the word out, it’s an amazing community. It’s more than just burned-out buildings.”

His brother and business partner, Paul, 31, added, “So many non-Italians have no idea about Arthur Avenue and we want to reintroduce everyone to the Bronx through the beer hall.”

The brothers have been working on re-branding the borough for six years, along with Anthony’s high school friend John Martin, 34, another partner in the bar. They started a business called Mainland Media out of the Ramirez home in Parkchester, designing and selling Bronx hoodies, hats, posters, patches, postcards, pins and T-shirts. Two shirts with retro lettering will be sold at the Museum of Modern Art’s design store this spring.