To start, there are numerous guests, including musicians like the Doubleclicks, Molly Lewis, Paul & Storm and Seth Boyer. Actress Ashly Burch, Penny Arcade's Jerry Holkins and others will also make appearances. And of course, there's the obligatory mix of auctions and giveaways, including the all-important 10th anniversary Jenga set.

The charity isn't the biggest (Extra Life raises millions each year), but its unique non-stop, single-game hook has its allure. The charity managed to raise almost $684,000 in 2015, and each year has represented a big jump in donations. In short: the odds are good that kids in hospitals will have something to celebrate when Desert Bus 10 finally wraps up.