of the University of Pennsylvania can has cortex?

An intensive summer institute for non-neuroscientists seeking a better understanding of the science behind the proliferation of new “neurofields” including neuroethics.



)

control condition) in

(a)

(b)

Our results were hypothesis driven so comparisons were only tested for the major structures of the frontal, temporal, and parietal lobes, as well as the amygdala, hippocampus, striatum, and thalamus, and thus a correction for multiple comparisons was not performed.

Of all places, the FaithWorld blog at Reuters has some excellent coverage of the ongoing Penn Neuroscience Boot Camp The post begins with " god spot? no there's not " researcher Dr. Andrew Newberg , who has done neuroimaing studies of glossolalia (or speaking in tongues ) and meditative prayer The figure above illustrates the singing state (and the glossolalia state in. The authors say there is decreased regional cerebral blood flow (rCBF) bilaterally in the frontal lobes and unilaterally in the left caudate during glossolalia, so we'll just have to take their word for it . BUT:

[I don't think that having a hypothesis exonerates one from correcting for multiple comparisons.]

So should we be skeptical of these pretty pictures? Yes! The press routinely portrays fMRI as capable of mind reading, for example, and lie detection. However, Aguirre (an expert in fMRI methodology) says this is “science fiction, science fantasy.” What are his reasons for skepticism? FaithWorld outlines them in Beware brain scientists bearing gifts (gee-whiz journalists too…):

scientific awesomeness — “This is an incredible technology. Neuroimaging is not phrenology. It really is a scientific discipline that has reproducible results that makes valuable predictions that explain larges areas of cognition and cognitive neuroscience that previously had been inaccessible.”

— “This is an incredible technology. Neuroimaging is not phrenology. It really is a scientific discipline that has reproducible results that makes valuable predictions that explain larges areas of cognition and cognitive neuroscience that previously had been inaccessible.” image properties — “There’s definitely an esthetic in the presentation of this data. People see this as a natural aspect of the brain, not the result of tests. Some groups made a very wise investment in the display technology for how neuroimaging results were reported. Those were the images that got displayed on the covers of the top scientific journals and made a splash.”

— “There’s definitely an esthetic in the presentation of this data. People see this as a natural aspect of the brain, not the result of tests. Some groups made a very wise investment in the display technology for how neuroimaging results were reported. Those were the images that got displayed on the covers of the top scientific journals and made a splash.” thresholding — The brain images leave out data outside the main focus. “This contributes to the overly localised view of brain function. So we say, ‘ah this is the spot for love’ or whatever, because it’s all that we see.”

— The brain images leave out data outside the main focus. “This contributes to the overly localised view of brain function. So we say, ‘ah this is the spot for love’ or whatever, because it’s all that we see.” overinference — “It’s very easy to believe a lot of things about these images that might not be true… It’s also implied that when you’ve found activisation in a region, you’ve found the region ‘for’ something. But what does that mean?”

— “It’s very easy to believe a lot of things about these images that might not be true… It’s also implied that when you’ve found activisation in a region, you’ve found the region ‘for’ something. But what does that mean?” chicken versus egg problem — “Just because you find a difference between groups in some brain imaging measure does not mean that structural difference was genetically determined.” But the brain also develops according to its owner’s environment and experience, so this is too narrow a focus.

— “Just because you find a difference between groups in some brain imaging measure does not mean that structural difference was genetically determined.” But the brain also develops according to its owner’s environment and experience, so this is too narrow a focus. lurking Cartesian dualism — “In the way we think about people’s actions and describe the effect of diseases or drugs, there is frequently a lurking dualism there. We say, ‘oh it wasn’t his fault, his brain did that.’ Well, who else could it have been? Where else could those thoughts and feeling or plans have come from, except in the brain? This idea that the brain and the mind are separate is part of what makes these images so remarkable. Wow look! Here’s a part of the brain that’s more active when you’re feeling romantic love or not! That’s just astounding to folks who would have thought romantic love was outside the brain, in the heart or the soul and far away.”



Cartesian dualism — “In the way we think about people’s actions and describe the effect of diseases or drugs, there is frequently a lurking dualism there. We say, ‘oh it wasn’t his fault, his brain did that.’ Well, who else could it have been? Where else could those thoughts and feeling or plans have come from, except in the brain? This idea that the brain and the mind are separate is part of what makes these images so remarkable. Wow look! Here’s a part of the brain that’s more active when you’re feeling romantic love or not! That’s just astounding to folks who would have thought romantic love was outside the brain, in the heart or the soul and far away.” illusion of inferential proximity — “It doesn’t automatically follow that a brain imaging technology is going to give you greater inferential leverage on a question than just talking to somebody. There’s an illusion that somehow you’re getting much closer to the behavior you want to measure, just because you’re measuring a brain image. That might not be the case.”



— “It doesn’t automatically follow that a brain imaging technology is going to give you greater inferential leverage on a question than just talking to somebody. There’s an illusion that somehow you’re getting much closer to the behavior you want to measure, just because you’re measuring a brain image. That might not be the case.” ease of imaging — Many hospitals have brain scanners and researchers can use them and free imaging software to create impressive images. “If you have an internet connection and a scanner, you can be a cognitive neuroscientist and publish a paper. Lots of the variance in the lousy scientific papers over these years can be explained this way. What will come out will be a well-formed brain image that will give the impression you must be a very good scientist because you created something that looks very polished.”

References

Psychiatry Res.

Psychiatry Research: Neuroimaging

J Cog Neurosci.