Mammalian Biology: ImmunologyGroup LeaderKanury Venkata Subba RaoICGEB LaboratoriesICGEB CampusAruna Asaf Ali Marg110 067 New Delhi, INDIAE-mail: kanury@icgeb.res.inOffice tel: +91-11-26741680Office fax: +91-11-26742316EducationPune University, Department of Chemistry, Pune, India, MSc, 1979MS University, Department of Chemistry, India, PhD, 1983Career HistorySince 1995, Group Leader of the Immunology Group, International Centre for GeneticEngineering and Biotechnology (ICGEB), New Delhi, India.1991-1994, Assistant Scientist, ICGEB New Delhi.1988-1991, Research Scientist, ICGEB New Delhi.Teaching ActivityTutoring activities in the ICGEB Ph.D. Programme.Scientific ActivityOur long-term interest is in understanding the regulatory parameters that influence theoutcome of an immune response. Within this our current focus is to understand themechanisms controlling plasticity in receptor-initiated signaling pathways. The experimentalstrategy involves a ‘systems level’ analysis of the antigen receptor-dependent signaltransduction network. We measure the kinetic and quantitative contributions of variousintermediates in the signaling pathways and then monitor how these contributions aremodulated in response to specific perturbations within the network. Our larger goal is todelineate the overall structure of this network and also to characterize its dynamic features.We are particularly interested in deriving both quantitative and qualitative measures of signaloutput under conditions where the receptor is differentially activated. The aim here is toeventually understand how such information processing impacts on the gene expressionprofile.Selected publications