The United Kingdom's Parliament on Tuesday voted overwhelmingly against British Prime Minister Theresa May's Brexit deal, delivering a blow to her plan to leave the European Union.

The Parliament's lower house, the House of Commons, voted 432-202 to reject May's plan in one of the biggest defeats for a prime minister in recent British history, The New York Times reported.

There is little certainty about what will happen next, as there is no consensus on a path forward on Brexit.

Labor Party leader Jeremy Corbyn on Tuesday called for a vote of "no confidence" in May's government, German broadcaster Deutsche Welle reported.

The failure of the Tuesday vote came after months of negotiating between the EU and U.K., with May pressing this deal as the only viable option for Brexit. Britain's departure from the EU had been set to take place on March 29.

The negotiations opened up rifts within May's party and among the country's lawmakers.

The deal was rejected by lawmakers from within May's party as well as other parties. May had expected to lose the vote, according to the Times, though her allies attempted to whip up support in the days prior.

May earlier Tuesday called the vote a "historic decision."

"The responsibility on each and every one of us at this moment is profound," May said, according to the Times. "This is a historic decision that will set the future of our country for generations."

Almost 52 percent of U.K. voters supported Brexit in a 2016 referendum.

Updated at 3:09 p.m.