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Four people were sent to hospital Saturday afternoon in a serious collision that shut down part of the southwest leg of Anthony Henday Drive.

The multi-vehicle crash happened at 1:40 p.m. in the westbound lanes between the Terwillegar Drive and Cameron Heights overpasses, according to Edmonton police.

READ MORE: 26-year-old woman killed in collision on Anthony Henday Drive

Two vehicles were involved in the crash. Alberta Health Services said an adult in their 30s and three children were transported via ambulance in stable condition, while others on scene declined to go to hospital.

Police said three injured people — two boys and a woman — were in one car, while the fourth patient was in the other vehicle. All had non-life-threatening injuries.

Terwillegar West closed! Have to take the exit. Henday below covered in snow, so it’s been closed for most of the day. Fatality investigation?? #yegtraffic pic.twitter.com/HdfMzUlTDr — Courtney Schultz (@courtxschultz) December 29, 2018

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North and westbound traffic on Anthony Henday Drive was being diverted onto Terwillegar Drive and Rabbit Hill Road, and drivers were asked to avoid the area.

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Traffic on the major ring road was backed up several kilometres because of the closure, which ended around 5 p.m.

The EPS Major Collision Investigations Section is investigating, but police believe snowy roads were a factor in the crash.

Poor road conditions contributed to many collisions in the Edmonton region on Saturday, including a large pileup on the Yellowhead west of the city involving about 30 vehicles.

READ MORE: Large pileup near Spruce Grove prompts RCMP warning of poor road conditions

Edmonton police said 122 collisions were reported over a 24-hour period, from 5 p.m. Friday to the same time on Saturday.

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One of the collisions, which happened Friday night on the southeast leg of the Henday, claimed the life of a 26-year-old woman. Eight other collisions left people with injuries, while another 22 crashes were hit-and-runs.

Mounties said northern, western and central Alberta was experiencing heavy snowfall and extremely poor road conditions, and RCMP advised drivers to reconsider travel at this time.

Edmonton police asked drivers to slow down and allow themselves extra time to reach their destination.