THE Upper East Side town house where Andy Warhol created some of his earliest and most influential Pop Art is about to go on the market, giving Warhol scholars and fans a rare opportunity to explore the space where he painted his early Campbell’s soup cans, dollar bills and comic strips.

The modest 16-and-a-half-foot-wide five-story house, at 1342 Lexington Avenue near 89th Street, is part of a row designed in 1889 by Henry J. Hardenbergh, the architect of the Plaza Hotel and the Dakota. Warhol bought it in 1959 and moved in with his mother.

He lived there until 1974, and in the early 1960s used the ground floor as his studio, propping his paint-by-number canvases against a large fireplace mantel in a wood-paneled room. The house is often regarded as the first in a series of Warhol factories in Manhattan.

In 1974, he leased it to Frederick W. Hughes, his business manager and later the executor of his estate. In 1989, Mr. Hughes bought it from the Warhol estate for $593,000 and kept a large Warhol portrait of Prince Charles in the foyer. After Mr. Hughes’s death in 2001, it was sold to Dennis Omar and Nancy Smith of Analytic Partners, a global marketing research firm, for $2.55 million.