Dave B. Mitchell ... Festus / Dog - Dead Money DLC / God - Dead Money DLC (voice)

Fred Tatasciore ... Tabitha / Rhonda / Tour Guide / Mr. Janitor / Mr. Handy / Doctor Orderly MD PHD DDS - Old World Blues DLC / Sparks - Old World Blues DLC / Mister Orderly - Old World Blues DLC (voice)

Wil Wheaton ... Robobrain / Super-Ego - Old World Blues DLC / X-8 Robobrain - Old World Blues DLC (voice)

Zoë Bell ... Melissa / Diane / Linda Schuler / Alice Hostetler / Brotherhood of Steel Initiate / Caravaneer / Crimson Caravan Trader / Crimson Caravan Guard / Destitute Traveler / Gambler / Great Khan / Gun Runner Guard / NCR Engineer / Prospector / Traveler (voice) (as Zoe Bell)

Jude Ciccolella ... Thomas Hildern / Mortimer / Dusty McBride / Johnson Nash / Orion Moreno / Chomp Lewis / Crandon / Gunderson Hired Hand / Gambler / Traveler (voice)

Emerson Brooks ... McMurphy / General Lee Oliver / Major Polatli / Ambassador Dennis Crocker / Ranger Andy / 10 of Spades / Jean-Baptiste Cutting / Eddie / Sammy Wins / Tyrone / Bryce Anders / Romanowski / Corporal Sterling / Sergeant McCredie / Lieutenant Monroe / Doctor Alex Richards / Sergeant Kilborn / Jules / Daniel Wyand / Dermot / Frank Weathers / Gourd / Private Jeremy Watson / Johnny / Logan / Ranger Milo / Marco / Private Reynolds / Ranger Stevens / Troike / Boomer Chef / Boomer Guard / Caravaneer / Crazed Chem Addict / Crucified Trooper / Escaped Convict / Gambler / Great Khan / Gomorrah Entrance Guard / Goodsprings Settler / Gunderson Hired Hand / Injured Trooper / Jackal Gang Member / Mercenary / NCR Engineer / NCR Heavy Trooper / NCR Military Police / NCR Ranger / NCR Recruit / NCR Trooper / NCR Trooper MP / NCR Veteran Ranger / New Vegas Citizen / North Vegas Resident / Novac Settler / Omerta Thug / Outer Vegas Defender / Powder Ganger / Prospector / Refugee / Thug / Traveling Merchant / Vault 34 Dweller / Viper Gunslinger / Viper Leader / Wastelander (voice)

Marc Graue ... Super Mutant / Davison / Keene (voice)

Robin Atkin Downes ... Super Mutant / Deputy Beagle / Mr Gutzy Robots / Creature Mutants / Ironbelly - Old World Blues DLC (voice)

Chris Andrew Ciulla ... Ghoul / Harland / Hadrian / Grecks / Private Kyle Edwards / Norton / Klamath Bob / Dennis / NCR Ranger / NCR Veteran Ranger / Bright Follower (voice) (as Chris Ciulla)

Sam Riegel ... Ghoul / Chris Haversam / Rotface / Andy Scabb / Bert Gunnarsson / Philip Lem / Rotson / NCR Ranger / Bright Follower (voice)

Karen Strassman ... Ghoul / Beatrix Russell / Calamity / Followers' Guard / Bright Follower / Wastelander (voice)

Suzan Brittan ... Ghoul / Keely / Gomorrah Bartender / Bright Follower (voice)

Sam Cohen ... Children / Pete / Legion Child / Mini Boomer / New Vegas Citizen / Refugee (voice)

Ashley McGullam ... Children / Lindsay / Melody / Stacey / Mini Boomer / Refugee / New Vegas Citizen / Atomic Wrangler Crier (voice)

Anthony Crehan ... Children / The Forecaster / Hector / Max / Legion Child / Mick and Ralph's Crier / Mini Boomer / New Vegas Citizen / Refugee (voice)

Zeus Mendoza ... Sergeant Daniel Contreras / Ezekiel / Chavez / Nero / Genaro / Scrambler / Caleb McCaffery / Kenny Weathers / Wayne / Big Beard / Atomic Wrangler Guard / Beggar / Bodyguard for Hire / Crucified Slave / Drunk / Escaped Convict / Followers' Guard / Followers' Medical Student / Freeside Thug / Gomorrah Bartender / Gomorrah Floor Manager / Kings Gang Member / Local / NCR Engineer / Omerta Thug / Powder Ganger / Powder Ganger Bodyguard / Roulette Dealer / Van Graff Thug (voice) (as Alex Mendoza)

Andrea Thompson ... Dazzle / Lady Jane / Hooker / Disguised Hooker / Card Dealer (voice)

April Stewart ... Mags / Ranger Ghost / Lieutenant Haggerty / Private Christina Morales / Private Ortega / Sergeant Reyes / Ranger Lineholm / Captain Gilles / Captain Marie Pappas / Raquel / Jacklyn / Liza O'Malley / Doctor Alvarez / Doctor Luria / Followers' Guard / Local / NCR Heavy Trooper / NCR Trooper / NCR Veteran Ranger (voice)

Ari Rubin ... Fantastic / Meyers / Dawes / Little Buster / Miguel / Jack / Argyll / Chet / Ted Gunderson / Dale Barton / Cursor Lucullus / Cato Hostilius / Barton Thorn / Carter / Roller / Weather Station Guard / Boomer Chef / Boomer Guard / Centurion / Crazed Chem Addict / Jackal Gang Member / Legion Explorer / Legionary Assassin / Legionary Blacksmith / Legionary Main Gate Guard / New Vegas Citizen / Powder Ganger / Powder Ganger Bodyguard / Prime Legionary / Prospector / Recruit Legionary / Veteran Decanus / Veteran Legionary / Vikki and Vance Dealer / Vikki and Vance Floor Manager / Viper Gunslinger (voice)

Avery Kidd Waddell ... Malcolm Holmes / Boxcars / Stanton / Simon / Joe Cobb / Hannigan / Samuel Cooke / Dobson / Chauncey / Roy Gottlieb / Brotherhood of Steel Scout / Crucified Slave / Escaped Convict / Great Khan / Gun Runners Guard / Gun Runners Gunsmith / Kings Gang Member / NCR Engineer / NCR Ranger / NCR Trooper / NCR Heavy Trooper / Powder Ganger / Powder Ganger Bodyguard / Van Graff Thug (voice) (as Avery Waddell)

Cindy Robinson ... Angela Williams / Francine Garret / Corporal Betsy / Melissa Watkins / Michelle Kerr / Sammy Weathers / Arms Merchant / Brotherhood of Steel Initiate / Caravaneer / Crimson Caravan Guard / Gambler / Gun Runners Guard / Gun Runners Gunsmith / Local / NCR Engineer / NCR Prospector / Refugee / Street Vendor / Vault 3 Fiend Guard / Dr. Howard - Lonesome Road DLC / The Kid - Lonesome Road DLC / Trooper Gleason - Lonesome Road DLC (voice)

Courtenay Taylor ... Gloria Van Graff / Janet / Jas Wilkins / Morgan Blake / Mrs. Hostetler / Lupe / Anne / Rachel / Assistant / Boulder City Worker / Caravaneer / Crimson Caravan Guard / Gambler / NCR Engineer / NCR Prospector / Refugee / Traveler (voice)

Dante Reid ... Fisto / Primm Slim / Vendortron / Protectrons / Construction Drone Forman - Old World Blues DLC / The Custodian - Old World Blues DLC (voice)

Debra Wilson ... Kate / Sweeite / Yvette / Boomer Teacher / Jackal Gang Member / Mercenary / New Vegas Citizen / Novac Settler / Prospector / The Tops Cashier / Traveling Merchant / Vault 34 Dweller / Vikki and Vance Dealer / Viper Gunslinger / Viper Leader / White Gloves Society Member (voice)

Gwen McGee ... Jane / Comm. Officer Lenk / Lacey / April Martimer / Ranger Gomez / NCR Ranger (voice)

Katherine Pawlak ... Sunny Smiles / Ada Straus / Knight Torres / Pauline Wins / Major Elizabeth Kieran / Martina Groesbeck / Allison Valentine / Stella / Violet / King Groupie / Bodyguard for Hire / Brotherhood of Steel Initiate / Crazed Chem Addict / Crimson Caravan Guard / Followers' Guard / Great Khan Armorer / Goodsprings Settler / Jackal Gang Member / Mercenary / NCR Ranger / NCR Trooper / New Vegas Citizen / North Vegas Resident / Novac Settler / Outer Vegas Defender / Prospector / Traveling Merchant / Vikki and Vance Dealer / Viper Gunslinger / Wastelander (voice)

Laura Bailey ... Julie Farkas / Lieutenant Carrie Boyd / Doctor Usanagi / Female Courier / Christine - Dead Money DLC / Starlet - Dead Money DLC (voice)

Lora Cain ... Trudy / Red Lucy / Emily Ortal / Pretty Sarah / Sarah Wientraub / Comm. Officer Scheffer / Siri / Brotherhood of Steel Initiate / Caravaneer / Crazed Chem Addict / Crucified Slave / Followers' Guard / Gambler / Jackal Gang Leader / Jackal Gang Member / Mercenary / New Vegas Citizen / Novac Settler / Prospector / Prospector Merchant / Traveling Merchant / Vault 34 Dweller / Vikki and Vance Cashier / Vikki and Vance Dealer / Viper Gunslinger / White Gloves Society Member / White Gloves Society Bouncer (voice)

Marianne Muellerleile ... Alice McLafferty / Old Lady Gibson / Pearl / Ethel Phebus / Daisy Whitman / Ruby Nash / Catty Clara / Irate Ida / Malefic Maud / Rancorous Ruth / Maude / Jeannie May Crawford / Marjorie / New Vegas Citizen / Traveling Merchant (voice)

Mela Lee ... Joana / Layla / Ranger Kudlow / Ranger Erickson / Private Gilbert / Great Khan / Gomorrah Receptionist / Hooker / NCR Trooper (voice)

Ron Yuan ... Ignacio Rivas / Tommy Torini / Paladin Ramos / Tom Anderson / Captain Ronald Curtis / Mike Lawson / Whitley / Paladin Sato / Paladin Todd / Boulder City Worker / Brotherhood of Steel Initiate / Brotherhood of Steel Scout / Caravaneer / Chairman Bodyguard / Clinic Guard / Crimson Caravan Guard / Crimson Caravan Trader / Destitute Traveler / NCR Mercenary / Quarry Worker / Refugee / The Top Bartender / The Tops Promoter / Traveler (voice)

Shane Johnson ... Manny Vargas / Regis / Old Ben / Canyon Runner / Jack / Roy / Mick / Oscar Velasco / Atomic Wrangler Guard / Centurion / Gourmand Food Supplier / Great Khan / Legionary Assassin / Legionary Blacksmith / Legion Explorer / Legion Vexillarius / Local / Praetorian Guard / Prime Decanus / Prime Legionary / Recruit Decanus / Recruit Legionary / Silver Rush Crier / Thug / White Gloves Society Head Waiter / Ultra-Luxe Floor Manager / Van Graff Thug / Veteran Decanus / Veteran Legionary (voice)

Steve Blum ... Justice Bloc HQ Security Tape Voice 2 (voice)

Yuri Lowenthal ... Elder Nolan McNamara / Lucius / Aurelius of Phoenix / Ringo / Oliver Swanick / Henry Jamison / Lars Taggart / Fitz / Keller / Scribe Ibsen / Knight Lorenzo / Ike / Antony / Otho / Alexus / Sergio / Rick Lancer / Alerio / Male Courier / Andrews / Daniel / Tapper / Boulder City Worker / Brotherhood of Steel Initiate / Brotherhood of Steel Scout / Caravaneer / Centurion / Crimson Caravan Guard / Crimson Caravan Trader / Crucified Slave / Drunk / Escaped Convict / Followers' Guard / Freeside Thug / Gambler / Great Khan / Kings Gang Member / Legion Explorer / Legionary Assassin / NCR Engineer / NCR Prospector / NCR Trooper / NCR Heavy Trooper / NCR Ranger / NCR Mercenary / Powder Ganger / Praetorian Guard / Prime Decanus / Prime Legionary / Quarry Worker / Recruit Decanus / Recruit Legionary / Refugee / Roulette Dealer / Strange Man / The Tops Promoter / Traveler / Vagrant / Van Graff Thug / Veteran Legionary / Wastelander (voice)

Barry Dennen ... Dean Domino - Dead Money DLC (voice)

Richard Herd ... Father Elijah - Dead Money DLC (voice)

Rick Pasqualone ... Daniel - Honest Hearts DLC (voice)

Dave Fennoy ... Jed Masterson - Honest Hearts DLC (voice)

Misi L. Lecube ... Walking Cloud - Honest Hearts DLC (voice)

Adam Gifford ... Salt-Upon-Wounds - Honest Hearts DLC (voice) (as Adam G.)

Christian Lanz ... Follows-Chalk - Honest Hearts DLC (voice)

Alejandro Furth ... Sorrows males - Honest Hearts DLC (voice)

Eliza Schneider ... Stella - Honest Hearts DLC / Sorrows females - Honest Hearts DLC (voice)

Eduardo Roman ... Dead Horse males - Honest Hearts DLC (voice) (as Eduardo Iduñate)

Elisa Gabrielli ... Dead Horse females - Honest Hearts DLC (voice)

Marcelo Tubert ... White Legs males - Honest Hearts DLC (voice)

Michelle C. Bonilla ... White Legs females - Honest Hearts DLC (voice) (as Michelle Bonilla)

Cam Clarke ... Dr. Mobius - Old World Blues DLC (voice)

Jim Ward ... Dr. Klein - Old World Blues DLC / Prototype Auto-Doc - Old World Blues DLC / Sink Central Intelligence Unit - Old World Blues DLC / Y-7 Trauma Override Harness - Old World Blues DLC (voice)

Beau Weaver ... Dr. Borous - Old World Blues DLC / Book Chute - Old World Blues DLC (voice)

Jocelyn Blue ... Dr. Dala - Old World Blues DLC / Sink - Old World Blues DLC (voice)

James Urbaniak ... Dr. 0 - Old World Blues DLC (voice)

Sunil Malhotra ... Player's Brain - Old World Blues DLC / X-8 Robobrain - Old World Blues DLC / Muggy - Old World Blues DLC (voice)

Veronica Belmont ... Christine Royce - Old World Blues DLC / Stealth Suit - Old World Blues DLC / Light Switch 01- Old World Blues DLC / Light Switch 02 - Old World Blues DLC (voice)

Jace Hall ... Toaster - Old World Blues DLC (voice)

Rashawn Underdue ... Blind Diode Jefferson - Old World Blues DLC (voice)

Monroe Hayden ... Captain - Dead Money DLC (voice)