I, Frankenstein is written and directed by Australian Stuart Beattie, whose writing credits include Australia and the Pirates of the Caribbean franchise. He also wrote and directed Tomorrow, When The War Began.

The film, which is being produced by Hopscotch Features in partnership with Lakeshore Entertainment, has been adapted from the graphic novel of the same name by Kevin Grevioux.

Film Victoria CEO Jenni Tosi said making the film in Victoria cemented the state as Australia's leading production destination.

"Film Victoria worked hard to secure this project for the state and for the local industry, so we're thrilled the talents of Victoria's screen practitioners get to shine on such a high-quality, large-scale production," Ms Tosi said in a statement.

Victorian Minister for Innovation, Services and Small Business Louise Asher said the film had created 500 jobs for cast and crew, and would inject up to $37 million into the state's economy.