Outraged Minnesotans stormed the dental office of Dr. Walter James Palmer Wednesday, infuriated that the big-game hunter forked over $50,000 to kill Zimbabwe’s most famous lion just for sport.

“Murderer,” read one sign emblazoned with a picture of a lion alongside a photo of Palmer.

“Everyone around the world knows who he is, so he might be put out of business entirely,” protester Isela Pena of Bloomington told The Post.

“Something like this really brings attention to the cruelty animals get that’s OK for some reason.”

By early evening, more than 300 protesters had gathered in front of Palmer’s Bloomington practice, River Bluff Dental, holding signs that said, “Prosecute Palmer,” and shouting, “Shut him down!”

Rachel Augusta, a member of the Animal Rights Coalition, which organized the protest, said, “People kill lions every day and it’s disgusting and horrible, but it’s not illegal. This is illegal.”

“This was a protected lion living in a sanctuary. The sad reality is that you can pay $50,000 and go kill a lion on a farm. It was illegal. He lured the lion out.”

The office remained closed all day Wednesday, with a sign posted on the front door in blood red reading, “You are a coward and a killer,” above a menagerie of stuffed lions, monkeys and other animals surrounding the door.

Palmer was said to be in hiding somewhere in the Twin Cities.

The business’s phone line was also disconnected, and even River Bluff Dental’s Facebook page was scrubbed from the Internet — but not before hundreds of furious posts.

“You are a disgusting excuse for a human being. I hope the bad press destroys your dental practice and you are extradited to Zimbabwe for trial. You have shamed America,” wrote Sarah Morrison.

It only got worse on the practice’s Yelp page, where thousands of people eviscerated the hunting enthusiast and his practice.

I understand and respect that not everyone shares the same views on hunting. - Dr. Walter James Palmer

“Would you trust a sociopath with violent tendencies with your mouth or your children’s mouths? I know I wouldn’t,” one message read.

Celebrities also continued to vent their rage, penning pointed tweets — including 70-year-old Mia Farrow, who sent Palmer’s Eden Prairie home address to her more than 654,000 followers. The tweet was later deleted.

PETA President Ingrid Newkirk said he should be “extradited, charged, and, preferably, hanged.”

In early July, Palmer went out with two African men — a professional hunter and a farm owner — and lured Cecil out of his sanctuary at Hwange National Park in the middle of the night with an animal carcass tied to a car, according to Zimbabwe wildlife officials.

Palmer shot the majestic creature with a bow and arrow, then tracked the wounded animal for another 40 hours before finally gunning him down.

They skinned and beheaded the majestic Cecil, known for his black-tinged mane, and destroyed his GPS collar so he couldn’t be tracked.

Authorities found his headless carcass a few days later, after a researcher noticed his collar had stopped sending data. They confiscated the head, which will be used as evidence in the investigation, according to Johnny Rodrigues of the Zimbabwe Conservation Task Force.

The carcass was left to vultures and other scavengers, and the bones from the rest of his body will be transformed into an anti-poaching memorial at Hwange National Park, TMZ reported.

The Zimbabwe Parks and Wildlife Management Authority and the Safari Operators Association of Zimbabwe deemed the hunt “illegal” because “the land owner was not allocated a lion on his hunting quota for 2015.”

Palmer, who is married with two kids, issued a statement to his patients, insisting he had “no idea” he had illegally killed a local treasure.

“I’ve been a lifelong hunter since I was a child growing up in North Dakota,” he wrote in the note to his “valued patients.”

“I don’t often talk about hunting with my patients because it can be a divisive and emotionally charged topic. I understand and respect that not everyone shares the same views on hunting.”

Palmer loves to pose proudly with his catch, and has slaughtered some 43 animals with his high-tech bow as part of the Safari Club International, a big-game hunting group with 55,000 members worldwide.

His kills include a polar bear, buffalo and mountain lion, many of which he’s posed with in pics posted to a Flickr account.

His hobby has gotten him in trouble with authorities before — once in 2008, when Palmer pleaded guilty for lying to federal wildlife officials about killing a black bear in Wisconsin, and once more in 2003, when he was convicted in a Minnesota court for fishing without a license.

The public outcry over Cecil’s death has prompted federal authorities to investigate as well.

A spokeswoman for the US Fish and Wildlife Service said the agency is “deeply concerned” about the killing.

“We are currently gathering facts about the issue and will assist Zimbabwe officials in whatever manner requested,” spokeswoman Vanessa Kauffman said in a statement.

The US Justice Department told the Minneapolis Star Tribune that it is “aware of the situation and . . . looking into the facts.”

Zimbabwe authorities have said they are looking for Palmer, but it remains unclear whether he will be charged with a crime. Since he was just a “client” and relied on his guides during the hunt, he could get off the hook, according to the UK charity LionAid.

With Post Wires