The West Coast Eagles' hopes of winning an historic first ever derby at Optus Stadium have been rocked with mounting injury doubts for star midfielders Elliot Yeo, Luke Shuey and Dom Sheed.

Elliot Yeo is in doubt for the derby. Credit:Quinn Rooney

Superstar forward Josh Kennedy is also nursing alarming leg soreness and faces fitness tests over the weekend ahead of the decision on whether the big scoring source plays against the Eagles' bitter enemy.

Kennedy, 30, has booted 514 West Coast goals and will create a new Eagles record with his next major at the game’s highest level.