Dr. Lim proposes a plan to encourage healthy competition between the residents. Dr. Melendez along with Dr. Brown and Dr. Resnick treat a father of twin girls who has appendicitis but complications occur when his the doctors discover he's taken too much extra medication. Morgan and Claire get to know each other's differences and develop a rivalry Dr. Lim along with Dr. Murphy and Dr. Kalu treat a young girl who has testicular cancer who is biologically male but identifies as female. Murphy learns to accept that you aren't confined to the gender you're born with. Doctor Andrews and his wife see a fertility specialist to help with their problems conceiving.