Two German patients have died of coronavirus, both in North Rhine-Westphalia, the nation’s most populous state.

The deaths, the first in Germany, were an elderly woman in the city of Essen and a man in the district of Heinsberg, Bloomberg reported Monday, citing the state’s health ministry.

Germany’s total number of cases surpassed 1,100 in recent days, with Chancellor Angela Merkel announcing emergency economic measures for the nation, which is heavily dependent on exports and trade with China specifically, as well as auto parts suppliers in northern Italy, the epicenter of the virus in Europe.

Germany has joined other countries in canceling major events that could be vectors for the virus, such as the ITB tourism trade show and the Leipzig book fair.

More extreme measures such as sealing off cities, which Italy has done for the hardest-hit northern regions, are also on the table, Bloomberg reported.