LSD administered in a medically supervised psychotherapeutic setting can be safe and generate lasting benefits in patients with a life-threatening disease. Explanatory models for the therapeutic effects of LSD warrant further study.

None of the participants reported lasting adverse reactions. The significant benefits as measured with the STAI were sustained over a 12-month period. In the QCA participants consistently reported insightful, cathartic and interpersonal experiences, accompanied by a reduction in anxiety (77.8%) and a rise in quality of life (66.7%). Evaluations of subjective experiences suggest facilitated access to emotions, confrontation of previously unknown anxieties, worries, resources and intense emotional peak experiences à la Maslow as major psychological working mechanisms. The experiences created led to a restructuring of the person’s emotional trust, situational understanding, habits and world view.

12 months after finishing LSD psychotherapy, 10 participants were tested for anxiety (STAI) and participated in a semi-structured interview. A Qualitative Content Analysis (QCA) was carried out on the interviews to elaborate about LSD effects and lasting psychological changes.

A recently published study showed the safety and efficacy of LSD-assisted psychotherapy in patients with anxiety associated with life-threatening diseases. Participants of this study were included in a prospective follow-up.

References

Abramson, H (ed) ( 1967 ) The Use of LSD in Psychotherapy and Alcoholism. New York : Bobbs-Merrill .

Google Scholar

Adlam, J, Zaman, R ( 2013 ) The role of BDNF and memory in major depressive disorder . Psychiatr Danub 2013( Suppl 2 ): S368 – S369 .

Google Scholar

Behrendt, RP ( 2003 ) Hallucinations: Synchronisation of thalamocortical gamma oscillations underconstrained by sensory input . Conscious Cogn 12: 413 – 451 .

Google Scholar Crossref | Medline

Béïque, JC, Imad, M, Mladenovic, L. ( 2007 ) Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex . Proc Natl Acad Sci U S A 104: 9870 – 9875 .

Google Scholar Crossref | Medline | ISI

Bullmore, E, Barnes, A, Bassett, DS. ( 2009 ) Generic aspects of complexity in brain imaging data and other biological systems . Neuroimage 47: 1125 – 1134 .

Google Scholar Crossref | Medline

Carhart-Harris, RL, Friston, KJ ( 2010 ) The default-mode, ego-functions and free-energy: A neurobiological account of Freudian ideas . Brain 133: 1265 – 1283 .

Google Scholar Crossref | Medline | ISI

Carhart-Harris, RL, Erritzoe, D, Williams, T. ( 2012a ) Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin . Proc Natl Acad Sci U S A 109: 2138 – 2143 .

Google Scholar Crossref | Medline | ISI

Carhart-Harris, RL, Leech, R, Hellyer, PJ. ( 2014 ) The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs . Front Hum Neurosci 8: 20 .

Google Scholar Crossref | Medline | ISI

Carhart-Harris, RL, Leech, R, Williams, TM. ( 2012b ) Implications for psychedelic-assisted psychotherapy: Functional magnetic resonance imaging study with psilocybin . Br J Psychiatry 200: 238 – 244 .

Google Scholar Crossref | Medline | ISI

Cohen, J ( 1960 ) Lysergic acid diethylamide: Side effects and complications . J Nerv Ment Dis 130: 30 – 40 .

Google Scholar Crossref | Medline | ISI

Cyr, M1, Landry, M, Di Paolo, T ( 2000 ) Modulation by estrogen-receptor directed drugs of 5-hydroxytryptamine-2A receptors in rat brain . Neuropsychopharmacology 23: 69 – 78 .

Google Scholar Crossref | Medline | ISI

Diesch, M ( 2014, in print ) LSD: Rückkehr in die klinische Forschung. Solothurn : Nachtschatten .

Google Scholar

Eliade, M ( 1975 ) Schamanismus und archaische Ekstasetechnik. Frankfurt : Suhrkamp .

Google Scholar

Fiorella, D, Rabin, RA, Winter, JC ( 1995 ) The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis . Psychopharmacology (Berl) 121: 347 – 356 .

Google Scholar Crossref | Medline

Gasser, P ( 1996 ) Die Psycholytische Therapie in der Schweiz von 1988 – 1993 . Schweiz Arch Neurol Psych 147: 59 – 65 .

Google Scholar

Gasser, P, Holstein, D, Michel, Y. ( 2014 ) Safety and efficacy of LSD-assisted psychotherapy for anxiety associated with life-threatening diseases . J Nerv Ment Dis 202: 513 – 520 .

Google Scholar Crossref | Medline

Gouzoulis-Mayfrank, E, Schreckenberger, M, Sabri, O. ( 1999 ) Neurometabolic effects of psilocybin, 3,4-methylenedioxyethylamphetamine (MDE) and d-methamphetamine in healthy volunteers. A double-blind, placebo-controlled PET study with [18F]FDG . Neuropsychopharmacology 20: 565 – 581 .

Google Scholar Crossref | Medline | ISI

Griffiths, RR, Johnson, MW, Richards, WA. ( 2011 ) Psilocybin occasioned mystical-type experiences: Immediate and persisting dose-related effects . Psychopharmacology 218: 649 – 665 .

Google Scholar Crossref | Medline | ISI

Griffiths, RR, Richards, WA, McCann, U. ( 2006 ) Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance . Psychopharmacology 187: 268 – 283 .

Google Scholar Crossref | Medline | ISI

Grob, CS, Danforth, AL, Chopra, GS. ( 2011 ) Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer . Arch Gen Psychiat 68: 71 – 78 .

Google Scholar Crossref | Medline

Grof, S ( 1975 ) Realms of the Human Unconscious. New York, NY : Viking .

Google Scholar

Grof, S ( 1980 ) LSD Psychotherapy. Pomona, CA : Hunter House .

Google Scholar

Grof, S, Goodman, LE, Richards, WA. ( 1973 ) LSD-assisted psychotherapy in patients with terminal cancer . Int Pharmacopsychiatry 8: 129 – 144 .

Google Scholar Crossref | Medline

Gusnard, DA, Akbudak, E, Shulman. ( 2007 ) Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function . Proc Natl Acad Sci U S A 98: 4259 – 64 .

Google Scholar Crossref

Hagmann, P, Cammoun, L, Gigandet, X. ( 2008 ) Mapping the structural core of human cerebral cortex . PLoS Biol 6: e159 .

Google Scholar Crossref | Medline | ISI

Halberstadt, AL, Geyer, MA ( 2011 ) Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens . Neuropharmacology 61: 364 – 381 .

Google Scholar Crossref | Medline | ISI

Hariri, AR, Drabant, EM, Weinberger, DR ( 2006 ) Imaging genetics: Perspectives from studies of genetically driven variation in serotonin function and corticolimbic affective processing . Biol Psychiatry 59: 888 – 897 .

Google Scholar Crossref | Medline

Hintzen, A, Passie, T ( 2010 ) The pharmacology of LSD. Oxford, UK : Oxford University Press .

Google Scholar

James, W ( 1902 ) The varieties of religious experience. New York : Longmans Green .

Google Scholar

Jiang, C1, Salton, SR ( 2013 ) The role of neurotrophins in major depressive disorder . Transl Neurosci 4: 46 – 58 .

Google Scholar Crossref | Medline

Kast, E ( 1967 ) Attenuation and anticipation: A therapeutic use of lysergic acid diethylamide . Psychiatric Quarterly 41: 646 – 657 .

Google Scholar Crossref | Medline

Kirchner, K ( 2010 ) LSD-supported psychotherapy: effects on daily life and longterm changes. MA Thesis, University of Zurich, Switzerland .

Google Scholar

Kurland, AA ( 1985 ) LSD in the supportive care of the terminally ill cancer patient . J Psychoactive Drugs 17: 279 – 290 .

Google Scholar Crossref | Medline

Leuner, H ( 1962 ) Die experimentelle Psychose. Berlin, Göttingen, Heildelberg : Springer .

Google Scholar Crossref

Leuner, H ( 1967 ) Present state of psycholytic therapy and its possibilities . In: Abramson, HA (ed) The use of LSD in Psychotherapy and Alcoholism. New York et al. : Bobbs-Merrill, pp . 101 – 116 .

Google Scholar

Leuner, H ( 1981 ) Halluzinogene. Bern : Huber .

Google Scholar

McGlothlin, W, Cohen, S, McGlothlin, MS ( 1967 ) Long lasting effects of LSD on normals . Arch Gen Psychiat 17: 521 – 532 .

Google Scholar Crossref | Medline

MacLean, KA, Johnson, MW, Griffiths, RR ( 2011 ) Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness . J Psychopharmacol 25: 1453 – 1461 .

Google Scholar SAGE Journals | ISI

Malleson, N ( 1971 ) Acute adverse reactions to LSD in clinical and experimental use in the United Kingdom . Brit J Psychiatry 118: 229 – 230 .

Google Scholar Crossref | Medline

MAPS ( 2007 ) LSD-assisted psychotherapy in persons suffering from anxiety associated with advanced-stage life threatening diseases . Study Report. Available at: http://maps.org/pdf/LDA1_FINAL_CSR_20Aug13.pdf ( ).

Google Scholar

Martín-Ruiz, R, Puig, MV, Celada, P. ( 2001 ) Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism . J Neurosci 21: 9856 – 9866 .

Google Scholar Crossref | Medline | ISI

Maslow, A ( 1962 ) Lessons from the peak experience . J Humanistic Psychol 2: 9 – 18 .

Google Scholar SAGE Journals

Maslow, A ( 1970 ) Religions, values, and peak experiences. New York : Viking .

Google Scholar

Maxwell, JA ( 2009 ) Designing a qualitative study . In: Bickman, L, Rog, DJ (eds) Handbook of Applied Social Research Methods. Los Angeles, CA : Sage, pp . 214 – 253 .

Google Scholar Crossref

Mayring, P, Glaeser-Zikuda, M (eds) ( 2008 ) Die Praxis der qualitativen Inhaltsanalyse. Weinheim : Beltz .

Google Scholar

Meert, TF ( 1996 ) Serotonin mechanisms in antipsychotic treatment: evidence from drug discrimination studies . In: Kane, JM, Moller, H-J, Awouters, F (eds) Serotonin in antipsychotic treatment. New York : Marcel Dekker , pp. 109 – 130 .

Google Scholar

Nichols, DE ( 2004 ) Hallucinogens . Pharmacol Ther 101: 131 – 181 .

Google Scholar Crossref | Medline | ISI

Northoff, G ( 2007 ) Psychopathology and pathophysiology of the self in depression – neuropsychiatric hypothesis . J Affect Disord 104: 1 – 14 .

Google Scholar Crossref | Medline | ISI

Pahnke, WN ( 1969 ) The psychedelic mystical experience in the human encounter with death . Harvard Theol Rev 62: 1 – 21 .

Google Scholar Crossref

Pahnke, WN, Kurland, AA, Unger, S. ( 1970 ) The experimental use of psychedelic (LSD) psychotherapy . JAMA 212: 1856 – 1863 .

Google Scholar Crossref | Medline | ISI

Passie, T, Halpern, JH, Stichtenoth, DO. ( 2008 ) The pharmacology of lysergic acid diethylamide: A review . CNS Neurosci Ther 14: 295 – 314 .

Google Scholar Crossref | Medline | ISI

Pizzagalli, DA ( 2011 ) Frontocingulate dysfunction in depression: toward biomarkers of treatment response . Neuropsychopharmacology 36: 183 – 206 .

Google Scholar Crossref | Medline | ISI

Pierce, PA, Peroutka, SJ ( 1989 ) Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex . Psychopharmacology 98: 118 – 122 .

Google Scholar Crossref

Puig, MV, Celada, P, Díaz-Mataix, L. ( 2003 ) In vivo modulation of the activity of pyramidal neurons in the rat medial prefrontal cortex by 5-HT2A receptors: relationship to thalamocortical afferents . Cereb Cortex 13: 870 – 82 .

Google Scholar Crossref | Medline | ISI

Raichle, ME ( 1998 ) The neural correlates of consciousness: An analysis of cognitive skill learning . Philos Trans R Soc Lond B Biol Sci 353: 1889 – 1901 .

Google Scholar Crossref | Medline

Richards, WA, Rhead, JC, Dileo, FB. ( 1977 ) The peak experience variable in DPT-assisted psychotherapy with cancer patients . J Psychoactive Drugs 9: 1 – 10 .

Google Scholar Crossref

Savage, C, Fadiman, J, Mogar, R. ( 1966 ) The effects of psychedelic (LSD) therapy on values, personality, and behavior . Int J Neuropsychiatry 2: 241 – 254 .

Google Scholar Medline | ISI

Schultes, RE, Hofmann, A ( 1980 ) Plants of the Gods: Origins of Hallucinogenic Use. London : Hutchinson .

Google Scholar

Schweizerische Krebsliga ( 2005 ) Schlussbericht Bestandesaufnahme psychosoziale Onkologie in der Schweiz. Bern : Krebsliga Schweiz .

Google Scholar

Sewell, RA, Halpern, JH, Pope, HG ( 2006 ) Response of cluster headache to psilocybin and LSD . Neurology 66: 1920 – 1922 .

Google Scholar Crossref | Medline | ISI

Spielberger, CS, Gorsuch, RL, Lushene, RE ( 1970 ) Manual for the State Trait Anxiety Inventory. Palo Alto, CA : Consulting Psychologists Press .

Google Scholar

Stuhrmann, A1, Suslow, T, Dannlowski, U ( 2011 ) Facial emotion processing in major depression: A systematic review of neuroimaging findings . Biol Mood Anxiety Disord 1: 10 .

Google Scholar Crossref | Medline

Terrill, James ( 1962 ) The nature of the LSD experience . J Nerv Ment Dis 135: 425 – 29 .

Google Scholar Crossref | Medline

Unger, SM ( 1963 ) Mescaline, LSD, psilocybin, and personality change . Psychiatry 26: 111 – 125 .

Google Scholar Crossref | Medline | ISI

Vaidya, VA, Marek, GJ, Aghajanian, GK. ( 1997 ) 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex . J Neurosci 17: 2785 – 2795 .

Google Scholar Crossref | Medline | ISI

Vázquez-Borsetti, P1, Cortés, R, Artigas, F ( 2009 ) Pyramidal neurons in rat prefrontal cortex projecting to ventral tegmental area and dorsal raphe nucleus express 5-HT2A receptors . Cereb Cortex 19: 1678 – 1686 .

Google Scholar Crossref | Medline

Vollenweider, FX, Geyer, MA ( 2001 ) A systems model of altered consciousness: Integrating natural and drug-induced psychoses . Brain Res Bull 56: 495 – 507 .

Google Scholar Crossref | Medline | ISI

Vollenweider, FX, Kometer, M ( 2010 ) The neurobiology of psychedelic drugs: Implications for the treatment of mood disorders . Nat Rev Neurosci 11: 642 – 651 .

Google Scholar Crossref | Medline | ISI

Vollenweider, FX, Leenders, KL, Scharfetter, C. ( 1997 ) Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis . Neuropsychopharmacology 16: 357 – 372 .

Google Scholar Crossref | Medline | ISI

Vollenweider, FX, Vontobel, P, Hell, D. ( 1999 ) 5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man – a PET study with [11C]raclopride . Neuropsychopharmacology 20: 424 – 433 .

Google Scholar Crossref | Medline

Vollenweider, FX, Vollenweider-Scherpenhuyzen, MF, Bäbler, A. ( 1998 ) Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action . Neuroreport 9: 3897 – 3902 .

Google Scholar Crossref | Medline | ISI

Weiss, RS ( 1995 ) Learning from Strangers: The Art and Method of Qualitative Interview Studies. New York, NY : Free Press .

Google Scholar