Anson R.M.

Guo Z.

de Cabo R.

Iyun T.

Rios M.

Hagepanos A.

Ingram D.K.

Lane M.A.

Mattson M.P. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc. Natl. Acad. Sci. USA. 100 : 6216-6220 View in Article Scopus (421)

PubMed

Crossref

Google Scholar

Arum O.

Bonkowski M.S.

Rocha J.S.

Bartke A. The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. Aging Cell. 8 : 756-760 View in Article Scopus (35)

PubMed

Crossref

Google Scholar

Arumugam T.V.

Phillips T.M.

Cheng A.

Morrell C.H.

Mattson M.P.

Wan R. Age and energy intake interact to modify cell stress pathways and stroke outcome. Ann. Neurol. 67 : 41-52 View in Article Scopus (150)

PubMed

Crossref

Google Scholar

Atkinson S.N.

Ramsay M.A. The Effects of Prolonged Fasting of the Body Composition and Reproductive Success of Female Polar Bears (Ursus maritimus). Funct. Ecol. 9 : 559-567 View in Article Scopus (160)

Crossref

Google Scholar

Bayer-Carter J.L.

Green P.S.

Montine T.J.

VanFossen B.

Baker L.D.

Watson G.S.

Bonner L.M.

Callaghan M.

Leverenz J.B.

Walter B.K.

et al. Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment. Arch. Neurol. 68 : 743-752 View in Article Scopus (91)

PubMed

Crossref

Google Scholar

Carlson A.J.

Hoelzel F. Apparent prolongation of the life span of rats by intermittent fasting. J. Nutr. 31 : 363-375 View in Article PubMed

Google Scholar

Castello L.

Froio T.

Maina M.

Cavallini G.

Biasi F.

Leonarduzzi G.

Donati A.

Bergamini E.

Poli G.

Chiarpotto E. Alternate-day fasting protects the rat heart against age-induced inflammation and fibrosis by inhibiting oxidative damage and NF-kB activation. Free Radic. Biol. Med. 48 : 47-54 View in Article Scopus (51)

PubMed

Crossref

Google Scholar

Cherel Y.

Groscolas R. Relationships between nutrient storage and nutrient utilisation in long-term fasting birds and mammals. in: Adams N.J. Slotow R.H. Proc. 22 Int. Ornithol. Congr., Durban. BirdLife South Africa , Johannesburg : 17-34 View in Article Google Scholar

Cherel Y.

Le Maho Y. Five months of fasting in king penguin chicks: body mass loss and fuel metabolism. Am. J. Physiol. 249 : R387-R392 View in Article PubMed

Google Scholar

Cherel Y.

Leloup J.

Le Maho Y. Fasting in king penguin. II. Hormonal and metabolic changes during molt. Am. J. Physiol. 254 : R178-R184 View in Article PubMed

Google Scholar

Cherel Y.

Robin J.P.

Walch O.

Karmann H.

Netchitailo P.

Le Maho Y. Fasting in king penguin. I. Hormonal and metabolic changes during breeding. Am. J. Physiol. 254 : R170-R177 View in Article PubMed

Google Scholar

Cherel Y.

Attaix D.

Rosolowska-Huszcz D.

Belkhou R.

Robin J.P.

Arnal M.

Le Maho Y. Whole-body and tissue protein synthesis during brief and prolonged fasting in the rat. Clin. Sci. 81 : 611-619 View in Article PubMed

Google Scholar

Descamps O.

Riondel J.

Ducros V.

Roussel A.M. Mitochondrial production of reactive oxygen species and incidence of age-associated lymphoma in OF1 mice: effect of alternate-day fasting. Mech. Ageing Dev. 126 : 1185-1191 View in Article Scopus (60)

PubMed

Crossref

Google Scholar

Duan W.

Mattson M.P. Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson’s disease. J. Neurosci. Res. 57 : 195-206 View in Article Scopus (355)

PubMed

Crossref

Google Scholar

Duan W.

Guo Z.

Jiang H.

Ware M.

Li X.J.

Mattson M.P. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proc. Natl. Acad. Sci. USA. 100 : 2911-2916 View in Article Scopus (321)

PubMed

Crossref

Google Scholar

Favier R.J.

Koubi H.E. Metabolic and structural adaptations to exercise in chronic intermittent fasted rats. Am. J. Physiol. 254 : R877-R884 View in Article PubMed

Google Scholar

Flegal K.M.

Kit B.K.

Orpana H.

Graubard B.I. Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA. 309 : 71-82 View in Article Scopus (1928)

PubMed

Crossref

Google Scholar

Fontán-Lozano A.

Sáez-Cassanelli J.L.

Inda M.C.

de los Santos-Arteaga M.

Sierra-Domínguez S.A.

López-Lluch G.

Delgado-García J.M.

Carrión A.M. Caloric restriction increases learning consolidation and facilitates synaptic plasticity through mechanisms dependent on NR2B subunits of the NMDA receptor. J. Neurosci. 27 : 10185-10195 View in Article Scopus (126)

PubMed

Crossref

Google Scholar

Fontana L.

Weiss E.P.

Villareal D.T.

Klein S.

Holloszy J.O. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell. 7 : 681-687 View in Article Scopus (234)

PubMed

Crossref

Google Scholar

Gonidakis S.

Finkel S.E.

Longo V.D. Genome-wide screen identifies Escherichia coli TCA-cycle-related mutants with extended chronological lifespan dependent on acetate metabolism and the hypoxia-inducible transcription factor ArcA. Aging Cell. 9 : 868-881 View in Article Scopus (23)

PubMed

Crossref

Google Scholar

Goodrick C.L.

Ingram D.K.

Reynolds M.A.

Freeman J.R.

Cider N. Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age. Mech. Ageing Dev. 55 : 69-87 View in Article Scopus (168)

PubMed

Crossref

Google Scholar

Grandison R.C.

Wong R.

Bass T.M.

Partridge L.

Piper M.D. Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster. PLoS ONE. 4 : e4067 View in Article Scopus (61)

PubMed

Crossref

Google Scholar

Guevara-Aguirre J.

Balasubramanian P.

Guevara-Aguirre M.

Wei M.

Madia F.

Cheng C.W.

Hwang D.

Martin-Montalvo A.

Saavedra J.

Ingles S.

et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci. Transl. Med. 3 : 70ra13 View in Article Scopus (413)

PubMed

Crossref

Google Scholar

Halagappa V.K.

Guo Z.

Pearson M.

Matsuoka Y.

Cutler R.G.

Laferla F.M.

Mattson M.P. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer’s disease. Neurobiol. Dis. 26 : 212-220 View in Article Scopus (312)

PubMed

Crossref

Google Scholar

Halberg N.

Henriksen M.

Söderhamn N.

Stallknecht B.

Ploug T.

Schjerling P.

Dela F. Effect of intermittent fasting and refeeding on insulin action in healthy men. J. Appl. Physiol. 99 : 2128-2136 View in Article Scopus (120)

PubMed

Crossref

Google Scholar

Harvie M.N.

Pegington M.

Mattson M.P.

Frystyk J.

Dillon B.

Evans G.

Cuzick J.

Jebb S.A.

Martin B.

Cutler R.G.

et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int. J. Obes. (Lond). 35 : 714-727 View in Article Scopus (280)

PubMed

Crossref

Google Scholar

Heilbronn L.K.

Smith S.R.

Martin C.K.

Anton S.D.

Ravussin E. Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am. J. Clin. Nutr. 81 : 69-73 View in Article PubMed

Google Scholar

Johnson J.B.

Summer W.

Cutler R.G.

Martin B.

Hyun D.H.

Dixit V.D.

Pearson M.

Nassar M.

Telljohann R.

Maudsley S.

et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic. Biol. Med. 42 : 665-674 View in Article Scopus (310)

PubMed

Crossref

Google Scholar

Kaeberlein T.L.

Smith E.D.

Tsuchiya M.

Welton K.L.

Thomas J.H.

Fields S.

Kennedy B.K.

Kaeberlein M. Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell. 5 : 487-494 View in Article Scopus (203)

PubMed

Crossref

Google Scholar

Le Maho Y.

Delclitte P.

Chatonnet J. Thermoregulation in fasting emperor penguins under natural conditions. Am. J. Physiol. 231 : 913-922 View in Article PubMed

Google Scholar

Le Maho Y.

Vu Van Kha H.

Koubi H.

Dewasmes G.

Girard J.

Ferré P.

Cagnard M. Body composition, energy expenditure, and plasma metabolites in long-term fasting geese. Am. J. Physiol. 241 : E342-E354 View in Article PubMed

Google Scholar

Lee C.

Safdie F.M.

Raffaghello L.

Wei M.

Madia F.

Parrella E.

Hwang D.

Cohen P.

Bianchi G.

Longo V.D. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 70 : 1564-1572 View in Article Scopus (130)

PubMed

Crossref

Google Scholar

Lee C.

Raffaghello L.

Brandhorst S.

Safdie F.M.

Bianchi G.

Martin-Montalvo A.

Pistoia V.

Wei M.

Hwang S.

Merlino A.

Emionite L.

de Cabo R.

Longo V.D. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci. Transl. Med. 4 ( ) https://doi.org/10.1126/scitranslmed.3003293 View in Article Scopus (267)

Crossref

Google Scholar

Longo V.D.

Ellerby L.M.

Bredesen D.E.

Valentine J.S.

Gralla E.B. Human Bcl-2 reverses survival defects in yeast lacking superoxide dismutase and delays death of wild-type yeast. J. Cell Biol. 137 : 1581-1588 View in Article Scopus (163)

PubMed

Crossref

Google Scholar

Mager D.E.

Wan R.

Brown M.

Cheng A.

Wareski P.

Abernethy D.R.

Mattson M.P. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J. 20 : 631-637 View in Article Scopus (146)

PubMed

Crossref

Google Scholar

Milanski M.

Arruda A.P.

Coope A.

Ignacio-Souza L.M.

Nunez C.E.

Roman E.A.

Romanatto T.

Pascoal L.B.

Caricilli A.M.

Torsoni M.A.

et al. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes. 61 : 1455-1462 View in Article Scopus (138)

PubMed

Crossref

Google Scholar

Mitchell J.R.

Verweij M.

Brand K.

van de Ven M.

Goemaere N.

van den Engel S.

Chu T.

Forrer F.

Müller C.

de Jong M.

et al. Short-term dietary restriction and fasting precondition against ischemia reperfusion injury in mice. Aging Cell. 9 : 40-53 View in Article Scopus (133)

PubMed

Crossref

Google Scholar

Pedersen W.A.

Mattson M.P. No benefit of dietary restriction on disease onset or progression in amyotrophic lateral sclerosis Cu/Zn-superoxide dismutase mutant mice. Brain Res. 833 : 117-120 View in Article Scopus (79)

PubMed

Crossref

Google Scholar

Peng W.

Robertson L.

Gallinetti J.

Mejia P.

Vose S.

Charlip A.

Chu T.

Mitchell J.R. Surgical stress resistance induced by single amino acid deprivation requires Gcn2 in mice. Sci Transl. Med. 4 ( ) https://doi.org/10.1126/scitranslmed.3002629 View in Article Scopus (90)

Crossref

Google Scholar

Raffaghello L.

Lee C.

Safdie F.M.

Wei M.

Madia F.

Bianchi G.

Longo V.D. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc. Natl. Acad. Sci. USA. 105 : 8215-8220 View in Article Scopus (264)

PubMed

Crossref

Google Scholar

Reed M.J.

Penn P.E.

Li Y.

Birnbaum R.

Vernon R.B.

Johnson T.S.

Pendergrass W.R.

Sage E.H.

Abrass I.B.

Wolf N.S. Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice. Mech. Ageing Dev. 89 : 21-43 View in Article Scopus (71)

PubMed

Crossref

Google Scholar

Reilly J.J. Adaptations to prolonged fasting in free-living weaned gray seal pups. Am. J. Physiol. 260 : R267-R272 View in Article PubMed

Google Scholar

Robin J.P.

Cherel Y.

Girard H.

Géloen A.

Le Maho Y. Uric acid and urea in relation to protein catabolism in long-term fasting geese. J. Comp. Physiol. B. 157 : 491-499 View in Article Scopus (63)

PubMed

Crossref

Google Scholar

Robin J.P.

Frain M.

Sardet C.

Groscolas R.

Le Maho Y. Protein and lipid utilization during long-term fasting in emperor penguins. Am. J. Physiol. 254 : R61-R68 View in Article PubMed

Google Scholar

Rothman S.M.

Griffioen K.J.

Wan R.

Mattson M.P. Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health. Ann. N Y Acad. Sci. 1264 : 49-63 View in Article Scopus (91)

PubMed

Crossref

Google Scholar

Safdie F.M.

Dorff T.

Quinn D.

Fontana L.

Wei M.

Lee C.

Cohen P.

Longo V.D. Fasting and cancer treatment in humans: A case series report. Aging (Albany, N.Y. Online). 1 : 988-1007 View in Article PubMed

Google Scholar

Sakamoto K.

Grunewald K.K. Beneficial effects of exercise on growth of rats during intermittent fasting. J. Nutr. 117 : 390-395 View in Article PubMed

Google Scholar

Shariatpanahi Z.V.

Shariatpanahi M.V.

Shahbazi S.

Hossaini A.

Abadi A. Effect of Ramadan fasting on some indices of insulin resistance and components of the metabolic syndrome in healthy male adults. Br. J. Nutr. 100 : 147-151 View in Article Scopus (50)

PubMed

Crossref

Google Scholar

Singh R.

Lakhanpal D.

Kumar S.

Sharma S.

Kataria H.

Kaur M.

Kaur G. Late-onset intermittent fasting dietary restriction as a potential intervention to retard age-associated brain function impairments in male rats. Age (Dordr.). 34 : 917-933 View in Article Scopus (65)

PubMed

Crossref

Google Scholar

Stranahan A.M.

Mattson M.P. Recruiting adaptive cellular stress responses for successful brain ageing. Nat. Rev. Neurosci. 13 : 209-216 View in Article PubMed

Google Scholar

Teng N.I.

Shahar S.

Manaf Z.A.

Das S.K.

Taha C.S.

Ngah W.Z. Efficacy of fasting calorie restriction on quality of life among aging men. Physiol. Behav. 104 : 1059-1064 View in Article Scopus (36)

PubMed

Crossref

Google Scholar

Tessitore L.

Tomasi C.

Greco M.

Sesca E.

Laconi E.

Maccioni O.

Ramo R.

Pani P. A subnecrogenic dose of diethylnitrosamine is able to initiate hepatocarcinogenesis in the rat when coupled with fasting/refeeding. Carcinogenesis. 17 : 289-292 View in Article Scopus (33)

PubMed

Crossref

Google Scholar

Thissen J.P.

Ketelslegers J.M.

Underwood L.E. Nutritional regulation of the insulin-like growth factors. Endocr. Rev. 15 : 80-101 View in Article PubMed

Google Scholar

Thissen J.P.

Pucilowska J.B.

Underwood L.E. Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture. Endocrinology. 134 : 1570-1576 View in Article Scopus (98)

PubMed

Crossref

Google Scholar

Varady K.A.

Hellerstein M.K. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am. J. Clin. Nutr. 86 : 7-13 View in Article PubMed

Google Scholar

Wan R.

Camandola S.

Mattson M.P. Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose improve functional and metabolic cardiovascular risk factors in rats. FASEB J. 17 : 1133-1134 View in Article PubMed

Google Scholar

Wei M.

Fabrizio P.

Hu J.

Ge H.

Cheng C.

Li L.

Longo V.D. Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9. PLoS Genet. 4 : e13 View in Article Scopus (301)

PubMed

Crossref

Google Scholar

Wei M.

Fabrizio P.

Madia F.

Hu J.

Ge H.

Li L.M.

Longo V.D. Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension. PLoS Genet. 5 : e1000467 View in Article Scopus (145)

PubMed

Crossref

Google Scholar

Weindruch R.

Walford R.L. The Retardation of Aging and Disease by Dietary Restriction. C.C. Thomas , Springfield, Ill., U.S.A. View in Article Google Scholar