A Great Dane bolted from Central Park on Tuesday morning and was fatally struck by a hit-and-run driver in Midtown, law enforcement sources and police said.

The dog had been running around off-leash inside the park at 59th Street and West Drive shortly before it was struck around 6:30 a.m. at West 57th Street and Broadway, cops said.

At one point, the canine ran into a 68-year-old cyclist, who lost control of his bike — sending him flipping over his handlebars, police said.

The bicyclist was taken to Mount Sinai Hospital with facial injuries, according to sources.

Shortly after, the Great Dane ran out of the park where it was struck by the vehicle, which did not remain at the scene, sources said.

It’s possible the motorist did not even know the dog was struck, a source said.

“A million people saw it,” said a nearby food stand owner of the crash. “A poor puppy was killed, and the car went zoom zoom. People were standing over the puppy’s body. I stayed away.”

The owner of the collar-wearing dog never showed up at the scene, sources said.

Additional reporting by Elizabeth Rosner