4:05 p.m. ET | FOX

Matchup rating: 38 | Spread: ARI -6.5 (46)

What to watch for: The matchup to watch will be Cardinals quarterback Kyler Murray vs. Washington edge rusher Chase Young. It's a matchup of two of the best young players in the NFL, last year's No. 1 pick and this year's No. 2 pick. It's a dream matchup. In their respective openers, Murray ran for 91 yards, and Young had 1.5 sacks. While this matchup won't determine the game, it'll definitely have an impact and will be quite fun to watch. -- Josh Weinfuss

Bold prediction: Washington will hold Murray to 50 yards rushing, and Young will sack him twice (giving him 3.5 sacks two games into his NFL career). Young can be moved around but had his best success as a right end against Jason Peters last week. He'll also be used on some stunts inside, and that's where he'll get Murray. But Murray will still throw for 225 yards in a win. -- John Keim

Stat to know: Washington quarterback Dwayne Haskins Jr. had an off-target percentage of 30% in Week 1, which ranked No. 31 out of 32 qualified quarterbacks.

Injuries: Washington | Cardinals

What to know for fantasy: Washington posted a sack on 16% of Philadelphia drop backs last week, the highest rate in the league and better than any performance it had last season. And since the beginning of last season, Murray ranks 27th in completion percentage when under pressure (37.7%). See Week 2 rankings.

Betting nugget: The total has gone under in nine of Arizona's last 11 September games. Read more.

Keim's pick: Cardinals 21, Washington 17

Weinfuss' pick: Cardinals 31, Washington 24

FPI prediction: ARI, 68.2% (by an average of 6.8 points)

Matchup must-reads: Young, Washington's pass rush 'as advertised' in promising start ... Hopkins has championship aspirations with Murray as his QB