An analysis in the CDC report showed that if these ACEs were eliminated, there could be a reduction of up to 1.9 million cases of heart disease (the leading cause of death in the U.S.), up to 21 million cases of depression and up to 2.5 million cases of obesity, using 2017 data. Other estimations in the analysis included a potential reduction in depressive disorder, cancer and stroke, as well as risky behaviors like smoking, and socioeconomic challenges like unemployment.