NSW Police have seized cannabis and methamphetamine as well as a rifle, a crossbow and a slingshot in raids on three houses on the state's southern border.

After a seven-month investigation, police arrested five people in Lavington, Springdale Heights and Wodonga on Wednesday.

A 31-year-old Springdale Heights woman has been charged with 17 counts of supplying or possessing a prohibited drug and is due to appear in Albury Local Court on July 14.

A 52-year-old Wodonga woman has been charged with drug and firearm offences, a 33-year-old Lavington woman has been charged with possessing and cultivating a prohibited drug, a 31-year-old Lavington man has been charged with possessing a prohibited drug, and a 36-year-old Springdale Heights man has been charged with possessing a prohibited drug.

AAP