The San Francisco 49ers have a history of taking risks on injured players coming out in the NFL Draft. With the 2016 draft just around the corner, who are some prospects the Niners may look at as high-risk, high-reward candidates?

If San Francisco 49ers fans want to bet on two things, they can all but certainly state the Niners will trade down at some point in the 2016 NFL Draft to accumulate more picks and take a shot on a prospect with an injury history.

49ers general manager Trent Baalke has a history of doing both. But let’s focus on the latter.

Last year, wide receiver DeAndre Smelter found his way to San Francisco in Round 4 despite a knee injury, which kept him off the field during his rookie season.

In previous years, the 49ers brought in injury-concern prospects like defensive end Tank Carradine, running back Marcus Lattimore, offensive guard Brandon Thomas and cornerback Keith Reaser, to name a few.

But these risky picks of Baalke’s “All ACL” team haven’t exactly panned out to the 49ers’ best hopes.

Lattimore retired before ever seeing NFL action. Carradine and Thomas haven’t exactly wowed despite being viewed as top-tier collegiate prospects. And the book is still out on Reaser. Who knows what the team will get out of Smelter.

And yet Baalke may take the same route in 2016 — not necessarily because he likes prospects who are injured but because some of them may simply be too enticing to pass on.

College standouts. Top talents. The potential is there.

But there comes some risk with Jaylon Smith, Myles Jack. https://t.co/vVXeoN310v — NFL (@NFL) April 17, 2016

So let’s take a look at some of these high-risk, high-reward prospects in whom the Niners may have interest.

Are they worth a shot even if the injury concerns are real?