Four children have been charged over a fire at the Big Brother house at Dreamworld on the Gold Coast.

The children, aged between 11 and 15, were charged with arson, while two additional nine-year-olds were released after assisting police with their investigation.

The fire at the dilapidated mansion property at Coomera broke out around 2.15pm yesterday, sending thick black smoke into the air.

Police allege the children entered the premises and deliberately lit the fire before they were seen running from the scene by witnesses.

They were eventually taken to the local police station and quizzed over the blaze, which was described as "suspicious".

Smoke rises from the site this afternoon. (9News)

A Queensland Fire and Emergency Services confirmed to 9News.com.au that multiple crews were required to tackle the blaze.

At the time, QFES warned smoke may affect motorists on the M1, north of Exit 54. Motorists in the area should drive with caution and to conditions.

The adjacent theme park is not affected but nearby residents affected by smoke should close their windows and doors, and keep any necessary respiratory medication close by.

The house at Dreamworld hosted 11 seasons of the popular reality television series, which first aired in 2001.

The abandoned house has recently been in media after a YouTuber filmed inside the dilapidated mansion.

Aussie YouTuber MuiTube recently filmed inside the dilapidated compound. (YouTube)