I've been maintaining a Sitecore framework that handles a number of common features: Meta Tags, Social Tags, Redirection, White Listing etc. To make it easier for site administrators to manage this configuration, I store configuration settings for each of these features in a single item, called "Site Configuration".

Unfortunately, I implemented all the fields in separate sections of the template for "Site Configuration", so after time this became a pretty monolithic template, and I was scared to refactor because I had a number of sites dependent on it and didn't want to have to try to reconfigure everything just to clean up dependency management.