Diving Down

This dynamic map allows for direct access to the genes showing reproducible differential expression between structure pairs by clicking on a fixed square. For example, clicking on the square representing the pair “SFG-m” (Superior frontal gyrus – medial aspect in the frontal lobe) and “LiG-str” (Lingual gyrus – striate containing primary visual cortex in the occipital lobe) returns a list of genes highly differentially expressed between these cortical regions. Included in this list is the proto-oncogene receptor tyrosine kinase MET. MET is widely known to have a strong anterior (frontal) to posterior (occipital) differential relationship as demonstrated here by clicking on the gene symbol to view the microarray heatmap for this gene.

Continue