Sen. Bernie Sanders Bernie SandersNYT editorial board remembers Ginsburg: She 'will forever have two legacies' Two GOP governors urge Republicans to hold off on Supreme Court nominee Sanders knocks McConnell: He's going against Ginsburg's 'dying wishes' MORE (I-Vt.) on Saturday urged Sens. Chuck Grassley Charles (Chuck) Ernest GrassleySenate Republicans face tough decision on replacing Ginsburg What Senate Republicans have said about election-year Supreme Court vacancies Biden says Ginsburg successor should be picked by candidate who wins on Nov. 3 MORE (R-Iowa) and Joni Ernst (R-Iowa) to vote against the Senate GOP plan to repeal and replace the Affordable Care Act.

"We need one more Republican vote, and I say to Sen. Grassley and Sen. Ernst, please take a hard look at what this disastrous legislation will do to the people of Iowa and the people of America," Sanders told progressive supporters in a speech in Des Moines, Iowa.

"I say to them – I beg of them – please vote no on this legislation," he continued.

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Sanders plea comes as Senate Republican leaders eye a vote on their healthcare measure next week.

The bill can only afford two Republican defections to get the 50 votes needed to pass, and so far, Sens. Susan Collins Susan Margaret CollinsJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Trump supporters chant 'Fill that seat' at North Carolina rally Momentum growing among Republicans for Supreme Court vote before Election Day MORE (R-Maine) and Rand Paul Randal (Rand) Howard PaulSecond GOP senator to quarantine after exposure to coronavirus GOP senator to quarantine after coronavirus exposure The Hill's Morning Report - Sponsored by National Industries for the Blind - Trump seeks to flip 'Rage' narrative; Dems block COVID-19 bill MORE (R-Ky.) have said they will not vote to approve the measure.

In a fiery address at "Revolution Iowa: From Protest to Power," Sanders railed against the Senate's healthcare proposal and took aim at Republicans for drafting the measure "behind closed doors."

"This legislation is so bad, that the Republicans have refused to hold one public hearing and all of their deliberations are behind closed doors," he said. "That's how bad this legislation is."

Sanders also cited opposition to the bill by outside groups such as the AARP and the American Medical Association.

"I say to Sens. Grassley and Ernst, if you don't believe me, then why don't you listen to virtually every major healthcare organization in this country. All of whom oppose this legislation."