Besides the change in eye color, there are other signs a snake is getting ready to shed. Its skin may appear dull, and it may become aggressive, hissy or refuse to be held or touched, in the case of captive snakes. Some may refuse food, at least until their eye color clears. Once their eyes clear, it means the shedding time is near. Some then regain their appetites, but others wait until after they actually finish the shedding process.