Wednesday night is the episode American Horror Story fans won’t want to miss. As EW exclusively revealed, episode 6 of AHS: Roanoke is the game-changing hour that turns the entire show on its head. “It’s the biggest plot twist we’ve ever done on the show,” said co-creator Ryan Murphy on a conference call this morning. “The season was sort of written as if the season was two different shows. Something happens where half the cast is revealed to be playing and doing something absolutely different than you’ve seen in the first five. There’s a startling announcement at the end of act 3 that resets the rest of the season up until episode 10.”