The Buckeyes will be multi-score favorites for this week's top-10 matchup with Penn State as Ohio State opens as a 19-point favorite over the Nittany Lions with the scoring total set at 59, according to Vegas Insider.

Ohio State was favored by fewer points against Indiana, Nebraska, Cincinnati and Wisconsin so far this season.

The Buckeyes have been double-digit favorites in every game so far this season, and have failed to cover just twice. Ohio State failed to cover the 28-point spread in the season opener against Florida Atlantic and did not cover the 52.5-point spread against Rutgers this weekend.

Bill Connelly of ESPN's SP+ model predicts a Buckeye victory by 14.7 points.