Russia and Iran have warned the US they will “respond with force” if their own “red lines” are crossed in Syria.

Following Friday’s cruise missile strike on a Syrian airbase, in retaliation for the chemical attack on Khan Sheikhoun earlier in the week, the alliance supporting Syrian President Bashar al-Assad made a joint statement threatening action in response to “any breach of red lines from whoever it is”.

“What America waged in an aggression on Syria is a crossing of red lines. From now on we will respond with force to any aggressor or any breach of red lines from whoever it is and America knows our ability to respond well,” the group’s joint command centre said.

Syria missile strike: Trump calls on 'all civilised nations to end the slaughter and bloodshed'

US President Donald Trump said the strike on al Shayrat airbase, near Homs, with some 60 Tomahawk missiles was “representing the world”. The base was allegedly used by Syrian forces to conduct the attack, which killed more than 70 people.

On Sunday the UK’s Defence Secretary, Sir Michael Fallon, demanded Russia rein in Mr Assad, claiming that Moscow is “responsible for every civilian death” in Khan Sheikhoun.

Sir Michael said the attack had happened “on their watch” and that Vladimir Putin must now live up to previous promises that Mr Assad’s chemical weapons had been destroyed.

Experts have dismissed Russia’s claim that a rebel chemical weapons facility caused the deaths.

Britain, the US and France accused Mr Assad’s regime of gassing civilians in the opposition-held town, but Damascus claimed it destroyed its toxic stockpiles following an international agreement struck in 2013.

Defence Secretary Michael Fallon says UK backs US airstrikes on Syria

The Russian defence ministry put out a competing version of events claiming legitimate Syrian air strikes against “terrorists” had struck a warehouse used to produce and store shells containing toxic gas, which were allegedly being sent to Iraq.

The joint command centre also said on Sunday the missile strike would not deter it from “liberating” Syria, and that the US military presence in the north of the country amounted to an illegal “occupation”.

Mr Putin and Iranian leader Hassan Rouhani have called for an objective investigation into the chemical attack.

US Secretary of State Rex Tillerson said on Sunday that Moscow had failed to carry out the 2013 agreement to secure and destroy chemical weapons in Syria.

US/South Korea joint exercise Operation Pacific Reach Show all 10 1 /10 US/South Korea joint exercise Operation Pacific Reach US/South Korea joint exercise Operation Pacific Reach US Marine soldiers patrol during the US-South Korea joint Exercise Operation Pacific Reach in Pohang, South Korea. North Korea is vowing tough counteraction to any military moves that might follow the US move to send the USS Carl Vinson aircraft carrier and its battle group to waters off the Korean Peninsula AP US/South Korea joint exercise Operation Pacific Reach South Korean soldiers take part in the Operation Pacific Reach joint logistic exercise in Pohang, South Korea Reuters US/South Korea joint exercise Operation Pacific Reach North Korea is vowing tough counteraction to any military moves that might follow the US move to send the USS Carl Vinson aircraft carrier and its battle group to waters off the Korean Peninsula AP US/South Korea joint exercise Operation Pacific Reach South Korean marine soldiers stand guard during the US-South Korea joint Exercise Operation Pacific Reach in Pohang, South Korea AP US/South Korea joint exercise Operation Pacific Reach A US Marine takes part in Operation Pacific Reach joint logistic exercise in Pohang, South Korea Reuters US/South Korea joint exercise Operation Pacific Reach A US Marine takes a position during a Combined Joint Logistics Over-the-Shore (CJLOTS) exercise as part of a joint defence exercise at a beach in Pohang Getty Images US/South Korea joint exercise Operation Pacific Reach South Korea and the United States kicked off a combined distribution exercise focused on integrating the two sides alliance logistics capabilities, in Pohang, 260 kms southeast of Seoul Getty Images US/South Korea joint exercise Operation Pacific Reach South Korea and the United States kicked off a combined distribution exercise focused on integrating the two sides alliance logistics capabilities Getty Images US/South Korea joint exercise Operation Pacific Reach A US Marine walks past a military vehicle during a Combined Joint Logistics Over-the-Shore (CJLOTS) exercise as part of a joint defence exercise in Pohang Getty Images US/South Korea joint exercise Operation Pacific Reach US Marines gather at a beach during a Combined Joint Logistics Over-the-Shore (CJLOTS) exercise as part of a joint defence exercise in Pohang, 260 kms southeast of Seoul, South Korea Getty Images

“The failure related to the recent strike and the recent terrible chemical weapons attack in large measure is a failure on Russia’s part to achieve its commitment to the international community,” he said on ABC’s This Week.

Mr Tillerson is expected in Moscow in the coming days for talks with Russian officials.

He stopped short of accusing Russia of being directly involved in the planning or execution of the attack.

But he said the US expected Russia to take a tougher stance against Syria by rethinking its alliance with Mr Assad because “every time one of these horrific attacks occurs, it draws Russia closer into some level of responsibility.”