Coronavirus clusters outside of China have prompted US officials to issue travel warnings for Italy and Iran after each country reported a spike in cases.

The US Centers for Disease Control and Prevention raised the threat to level-one status Sunday night for both countries, warning travelers to “practice usual precautions.”

The travel advisory noted that “multiple instances” of the coronavirus spreading within each country had been confirmed.

“This new coronavirus has caused severe disease and death in patients who developed pneumonia,” the advisories said. “Risk factors for severe illness are not yet clear, although older adults and those with chronic medical conditions may be at higher risk for severe illness.”

Italy has reported 219 people who have tested positive for the coronavirus and five who have died. Meanwhile, Iran’s government has said 12 people died from the virus, rejecting earlier reports that the death toll there had hit 50.

Visitors to the coronavirus-stricken destinations are encouraged to “avoid contact with sick people and clean their hands often by washing with soap and water for at least 20 seconds.”

Anyone who visits either country and experiences symptoms of the virus such as a fever, cough or difficulty breathing is urged to seek medical care, as well as to avoid contact with others, officials said.

The new advisories come as Italy has placed a dozen towns under quarantine in the wake of the coronavirus.

The country has effectively sealed off a dozen northern towns in the Lombardy and Veneto regions, two hotspots of the outbreak. Around 50,000 people are prohibited from leaving the towns for the next two weeks without permission.