The Community and Public Sector Union (CPSU) has lodged a dispute with the Fair Work Commission, alleging the CSIRO has unfairly tried to cut jobs in areas like climate science.

The CPSU has already launched action to halt a controversial restructure that would see hundreds of jobs lost.

However, the new dispute claims the CSIRO breached its enterprise agreement by not adequately trying to redeploy staff.

CPSU national secretary Nadine Flood said the cuts would affect hundreds of workers.

"Today we are going back to Fair Work ... arguing that CSIRO is unfairly targeting particular scientists and areas, such as climate change, and that they are not complying with their enterprise agreement," she said.

"They have picked on areas of research like climate change, and said that everyone in that area is redundant.

"We're arguing that that doesn't actually comply with their obligations to consider scientists' skills and whether they can be moved into other areas of research."

So far only voluntary redundancies have been implemented, however forced redundancies are expected to begin in July and August.

Ms Flood said the cuts would hit jobs in Victoria, Tasmania, southern Queensland and the ACT.

"The overall impact of this is that we are heading to one-in-four CSIRO scientists having lost their jobs, so it's an absolutely extraordinary process of gutting a world-class research organisation," she said.

"Already we've seen vital research abandoned in climate change and other areas, but the loss of these 275 further jobs nationally will have an enormous impact on our scientific capacity."