Cowboys at Jets, 4:25 p.m., CBS

Line: Cowboys -7 | Total: 43

The Luke Falk era is over. Asking the Jets (0-4) to suddenly snap into some form of relevance is too much, but with Sam Darnold, the team’s promising second-year quarterback — and unwitting subject of a fairly amusing meme — back from a bout with mononucleosis, they should at least rise above embarrassing. This week could still be a tough one, as the Cowboys (3-2) are reeling from consecutive losses and may be looking to prove a point about their offensive relevance against a lesser opponent. Pick: Cowboys -7

Eagles at Vikings, 1 p.m. Fox

Line: Vikings -3 | Total: 44

Philadelphia’s defense is not as good as it appeared in last week’s annihilation of the Jets, in which it produced 10 sacks and two interceptions. To be fair, no defense is that good. But if you combine that laugher with a huge win over Green Bay in Week 4, then building enthusiasm for the Eagles (3-2) seems warranted. The Vikings (3-2) are tough at home, but most likely can’t withstand Philadelphia’s strong pass-rush. Pick: Eagles +3

Seahawks at Browns, 1 p.m., Fox

Line: Seahawks -1.5 | Total: 47

A lot of the criticism of Baker Mayfield and the Browns (2-3) has been warranted, but the hubbub in the past week about Mayfield supposedly not shaking Richard Sherman’s hand — a melodrama that fizzled quickly when video emerged of the second-year quarterback clearly doing just that — indicates people may just want to be mad at the player and the team. The Seahawks (4-1) still have Bobby Wagner making plays all over the field, but their defense is otherwise weakened from previous seasons. That could give Mayfield some openings to take shots downfield to Odell Beckham Jr., but Seattle’s offense is strong enough to keep up with him, even on the road. Pick: Seahawks -1.5