Steven Soderbergh (Traffic, Side Effects, HBO’s “Behind the Candelabra”) will direct Clive Owen (Children of Men, HBO’s “Hemingway & Gellhorn”) in the entire ten-episode season of the Cinemax original series “The Knick,” which begins production in New York in September.

Michael Lombardo, president, HBO Programming, says, “We are thrilled that Steven and Clive have chosen to bring this unique and exciting series to Cinemax.”

Set in downtown New York in 1900, “The Knick” centers on Knickerbocker Hospital and the groundbreaking surgeons, nurses and staff, who push the bounds of medicine in a time of astonishingly high mortality rates and zero antibiotics.

The writing team of Jack Amiel and Michael Begler (Raising Helen, Big Miracle), who wrote the pilot for the series, will serve as executive producers, along with Soderbergh, Owen, Michael Sugar (Rendition) and Gregory Jacobs (“Behind the Candelabra”). Michael Polaire (“Behind the Candelabra”) produces. Kary Antholis, president, HBO Miniseries and CINEMAX Programming, and David Levine, vice president, HBO Entertainment, will oversee the series, which will debut on the network in 2014.