The New York state attorney general has begun issuing subpoenas to 33 financial institutions and investment advisers with ties to the Sackler family, part of an aggressive effort to track billions of dollars that prosecutors claim the family siphoned out of Purdue Pharma to hide profits gained from the company’s opioid painkillers.

The recipients of the subpoenas ranged from major Wall Street firms to obscure offshore holding companies as well as two family investment offices and four individual advisers , according to court documents. The action is part of a broad attempt to hold individual Sacklers, who are owners of Purdue Pharma, accountable in some measure for unleashing the opioid crisis that has killed more than 200,000 Americans over the past two decades.

Purdue Pharma is widely seen as playing a central role in creating the opioid epidemic by misleading doctors about its drug OxyContin’s addictive properties and playing down evidence that the drug was being abused.

New York State and others, most recently Arizona, have charged that as reports grew about Purdue’s marketing of OxyContin, the Sackler family began transferring money out of Purdue into a far-flung network of surrogate companies and foundations, installing successive generations of relatives as overseers, to keep the money away from the scrutiny of potential litigants.