Five teams of firefighters have contained a "fully involved" house fire blazing in Lane Cove, which has been posing a "major traffic hazard" due to thick smoke in the area.

Fire services were called to a property on the corner of Lihon Street and Burns Bay Road shortly before 6pm on Wednesday, after receiving "numerous" reports that a fire was blazing through the roof of the house.

An estimated 26 firefighters undertook "defensive firefighting" to control the fire, spraying water from three sides of the property, in an attempt to prevent the fire from spreading to neighbouring properties.

While the neighbouring properties were not affected, the house was destroyed, with the roof partially collapsing shortly before the fire was contained around 7.30pm.