Story highlights "Hillary Clinton is not running against me, she's running against change," Trump said

Trump's served up the biting remark in a speech just 17 days from Election Day

Gettysburg, Pennsylvania (CNN) Donald Trump on Saturday ratcheted up his attacks on his Democratic rival Hillary Clinton, accusing her of "running against all of the American people."

"Hillary Clinton is not running against me, she's running against change. And she's running against all of the American people and all of the American voters," the Republican nominee said Saturday, 10 minutes into a speech billed by his senior aides as his "closing argument" in the presidential race.

Trump's remark came as he argued that an outsider was needed to come into Washington and shake up the system, arguing that "we will never solve our problems by relying on the same politicians who created these problems in the first place."

But his accusation that Clinton is running against all Americans is the latest in a long line of escalating attacks against Clinton, whom he has previously called "the devil" and said he would seek to jail should he be elected president.

JUST WATCHED Trump: I am asking the American people to dream big Replay More Videos ... MUST WATCH Trump: I am asking the American people to dream big 00:50

A message left with the Clinton campaign seeking response to Trump's comments was not immediately returned. But Christina Reynolds, a Clinton spokeswoman, called Trump's speech -- in which he also threatened to sue women who have accused him of sexual impropriety -- "full of conspiracy theories."

Read More