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The teenage attacker detonated the explosive device at the Shah Noorani Shrine in the Khuzdar District of Balochistan, police sources told the Pakistani Express Tribune reports.

Eyewitnesses told local media that more than 500 people were attending a dance event at the memorial when the attack happened.

Emergency services have arrived at the scene of the blast – about 100km north of the port city of Karachi.

Dozens of casulties are now being rushed to the nearby town of Hub and to Karachi, rescue official Hakeem Nasi told Geo TV.

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It is not yet known exactly how many people were killed in the blast.

Hashim Ghalzai, a local district commissioner, said that the toll was based on initial reports, and could rise further.

Balochistan Home Minister Sarfaraz Bugti said told Express News: “Our focus is on rescue services at the moment. We can’t be certain about the exact number of casualties and the nature of attack that took place today."

Many women and children are reported to be among the casulties.

The suicide bomber was a boy of 14, police sources told local media.

Authorities have described it as the deadliest terror attack of 2016 in Pakistan, Dunya News reports.

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Pakistani Prime Minister Nawaz Sharif has condemned the attack, the Express Tribune reports.

Sufi Muslim worshippers at the shrine were performing dhamal – a trance-like dance – when the bomb hit.

Nawaz Ali, the shrine's custodian, said: "Every day, around sunset, there is a dhamaal here, and there are large numbers of people who come for this."

Extremists oppose Sufism, which is a tolerant, mystical denomination of Islam.

ISIS have claimed responsibility for a previous terror attack in the region.

It comes after dozens were killed in an attack on a police station in October.