Patients left paralysed by injury or illness could be back on their feet again, thanks to a breakthrough by Melbourne researchers who have designed a revolutionary bionic spine.

With human trials set for next year, the device implanted into the brain will enable patients with spinal cord injuries to control a robotic limb by harnessing the power of thought.

"It's the holy grail for research in bionics," said Terence O'Brien from the Royal Melbourne Hospital where patient trials will begin late next year.

Professor O'Brien is overseeing the groundbreaking project, which involves a team of 39 neurologists and biomedical engineers from the hospital, Melbourne University and the Florey Institute of Neuroscience and Mental Health.