tRNA microarray and ChIP–seq data that support the findings of this study have been deposited in the Gene Expression Omnibus under accession codes GSE116812 and GSE117240, respectively.

The human COAD, BRCA and SARC datasets were derived from the TCGA Data Hub on the University of California Santa Cruz Xena platform (http://xena.ucsc.edu/). The dataset derived from this resource that supports the findings of this study is available in the following links. COAD: https://xenabrowser.net/datapages/?dataset=TCGA.COAD.sampleMap%2FHiSeqV2_PANCAN&host=https%3A%2F%2Ftcga.xenahubs.net&removeHub=https%3A%2F%2Flocal.xena.ucsc.edu%3A7223; BRCA: https://xenabrowser.net/datapages/?dataset=TCGA.BRCA.sampleMap%2FHiSeqV2_PANCAN&host=https%3A%2F%2Ftcga.xenahubs.net&removeHub=https%3A%2F%2Flocal.xena.ucsc.edu%3A7223; SARC: https://xenabrowser.net/datapages/?dataset=TCGA.SARC.sampleMap%2FHiSeqV2_PANCAN&host=https%3A%2F%2Ftcga.xenahubs.net&removeHub=https%3A%2F%2Flocal.xena.ucsc.edu%3A7223. The human DLBCL data were derived from the National Cancer Institute Center for Cancer Genomics website: https://gdc.cancer.gov. The dataset derived from this resource that supports the findings of this study is available at https://gdc.cancer.gov/about-data/publications/DLBCL-2018.

Statistics source data for graphical representations and statistical analyses in Figs. 1–6 and Supplementary Figs. 1–6 are provided in Supplementary Table 3. All other data supporting the findings of this study are available from the corresponding author on reasonable request.