The new story picks up as Lizzie is just about to turn 30. She seemingly has it all - her dream job as an assistant to a fancy New York City interior designer, her dream guy, and a picturesque Brooklyn apartment - but things aren't always as they seem. With a little help from her old friends and some new ones to come, her well-meaning family and her 13-year-old alter-ego in animated form, Lizzie navigates the ups and downs of adulthood.