Senate Republicans are facing a potential intraparty brawl as they fight to hold on to the chamber next year.

Republicans are defending 22 seats in 2020, mostly in deep-red states, limiting Democrats’ pickup opportunities and increasing the odds of the GOP keeping the Senate.

But nasty primary fights brewing in a handful of key states could threaten to throw a curveball into the Republican strategy, potentially setting the party up for a repeat of previous cycles when conservatives caused headaches by defeating more mainstream GOP candidates, only to lose to Democrats in November.

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Three races have jumped into the spotlight as looming problem areas for Republicans: In Alabama and Kansas, where conservatives Roy Moore Roy Stewart MooreVulnerable Senate Democrat urges unity: 'Not about what side of the aisle we're on' Sessions hits back at Trump days ahead of Alabama Senate runoff Judge allows Roy Moore lawsuit over Sacha Baron Cohen prank to proceed MORE and Kris Kobach, respectively, are flirting with Senate bids, and in North Carolina, where Sen. Thom Tillis Thomas (Thom) Roland TillisThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting OVERNIGHT ENERGY: EPA head questions connection of climate change to natural disasters | Pebble Mine executives eye future expansion in recorded conversations | EPA questions science linking widely used pesticide to brain damage in children Liberal super PAC launches ads targeting vulnerable GOP senators over SCOTUS fight MORE (R-N.C) is viewed as vulnerable to a primary challenge.

“There are still Republicans ... who are upset that we gave away Senate seats in Nevada, Missouri and Indiana that were right there for the taking,” said Doug Heye, a former Republican National Committee spokesman. “So I think folks here [in Washington] are very mindful of that.”

A national GOP strategist added that “there’s a pretty broad recognition that we’ve got to nominate candidates who are electable, and unfortunately the party has learned that lesson the hard way.”

National Republican groups aren’t ruling out intervening in the three GOP primaries as part of an effort to fend off candidates viewed as unelectable in November, including Moore and Kobach, who have both lost statewide races.

The GOP frustration with a potential Senate bid by Moore boiled over this week after the former Alabama chief justice predicted he could beat Sen. Doug Jones (D) in a 2020 rematch after losing in a 2017 special election.

Moore doubled down Wednesday, telling The Associated Press that “everybody knows I can win.”

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A second Senate bid would be a nightmare for national Republicans, who view Moore as a guarantee that Jones will be reelected despite Trump winning the state by nearly 30 points in 2016.

Kevin McLaughlin, executive director of the National Republican Senatorial Committee (NRSC), has described the Senate GOP campaign wing’s stance as “ABRM: anyone but Roy Moore.”

Moore, during his Senate campaign, faced allegations of sexual misconduct with teenage girls from when he was in his 30s. Moore denied the allegations but Senate Republicans, including the NRSC, cut ties with him.

“There are a lot of Republicans in the state of Alabama who can beat Doug Jones, and Roy Moore has proven that he’s not one of them,” the national GOP strategist told The Hill. “We still think he could potentially be a force in a primary, and he’s not who we want as our general election nominee.”

Republicans point to Rep. Bradley Byrne Bradley Roberts ByrneBottom line Jerry Carl wins GOP Alabama runoff to replace Rep. Bradley Byrne Jeff Sessions loses comeback bid in Alabama runoff MORE (R-Ala.) or former Auburn University head football coach Tommy Tuberville as alternative candidates to Moore that the party could rally around as they seek to unseat Jones and win back the seat previously held by former Attorney General Jeff Sessions Jefferson (Jeff) Beauregard SessionsGOP set to release controversial Biden report Trump's policies on refugees are as simple as ABCs Ocasio-Cortez, Velázquez call for convention to decide Puerto Rico status MORE.

Trump, in a break from his 2017 stance, made it clear Wednesday that he does not want Moore to run, saying he “cannot win” and that Jones keeping the seat will have “devastating” repercussions.

"Republicans cannot allow themselves to again lose the Senate seat in the Great State of Alabama,” Trump said in a tweet Wednesday.

GOP strategists view Trump’s tweet urging Moore not to run, while caveating that he has nothing personally against the failed candidate, as a sign that the president and his supporters have learned a lesson from previous bloody primaries.

“I think the president’s comments were illuminating and on par with what the broader Republican Party believes in terms of Roy Moore and the Alabama Senate race,” said a second GOP operative. “I think the president highlights a very good point that Doug Jones is actively cheering for Roy Moore.”

Moore isn’t the only conservative causing heartburn for Republicans as they try to solidify their 2020 strategy. National Republicans have similar concerns about Kobach, who lost his 2018 bid to be Kansas’s governor and said earlier this month that he was still “actively considering” a 2020 Senate run.

The GOP strategist described the concerns about Kobach as national Republicans being “pro-winning” and “pro-keeping the majority.”

“He found a way to lose a statewide election” in Kansas, the strategist added.

Kobach lost his 2018 gubernatorial bid to Democratic nominee Laura Kelly by more than 4 percentage points.

Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellFEC flags McConnell campaign over suspected accounting errors Poll: 59 percent think president elected in November should name next Supreme Court justice Mark Kelly: Arizona Senate race winner should be sworn in 'promptly' MORE (R-Ky.) and his allies are hoping to persuade Secretary of State Mike Pompeo Michael (Mike) Richard PompeoTreasury sanctions individuals, groups tied to Russian malign influence activities Navalny released from hospital after suspected poisoning Overnight Defense: Pentagon redirects pandemic funding to defense contractors | US planning for full Afghanistan withdrawal by May | Anti-Trump GOP group puts ads in military papers MORE, who previously served as a House lawmaker from Kansas, to jump into the Senate race. Pompeo said in February that he had “ruled out” a bid, but national Republicans hope that it’s still early enough in the cycle that he could be wooed into changing his mind.

If Pompeo doesn’t run it would be a wide-open field to succeed retiring Sen. Pat Roberts Charles (Pat) Patrick RobertsThe Hill's Morning Report - Sponsored by Facebook - Washington on edge amid SCOTUS vacancy The Hill's Morning Report - Sponsored by National Industries for the Blind - Trump seeks to flip 'Rage' narrative; Dems block COVID-19 bill GOP senators say coronavirus deal dead until after election MORE (R-Kan.). A second GOP operative rattled off a list of names of potential candidates viewed in Washington as being a better GOP nominee than Kobach: Kansas Treasurer Jake LaTurner, former Gov. Jeff Colyer and Kansas Senate President Susan Wagle.

It’s not the first time Republicans have watched as conservative challengers have threatened to upset their game plan for keeping the Senate and holding onto what are viewed as reliably red-state, or flippable, seats.

During the 2012 cycle, then-Sen. Claire McCaskill Claire Conner McCaskillMomentum growing among Republicans for Supreme Court vote before Election Day Democratic-linked group runs ads in Kansas GOP Senate primary Trump mocked for low attendance at rally MORE (D-Mo.) was viewed as likely to lose her race until GOP nominee Todd Akin, who defeated more-mainstream picks during the primary, said that “if it's a legitimate rape, the female body has ways to try to shut that down.”

In the same election cycle, conservative challenger Richard Mourdock defeated longtime Sen. Richard Lugar (R-Ind.) during the primary, only to lose against Democratic candidate Joe Donnelly Joseph (Joe) Simon DonnellyHarris faces pivotal moment with Supreme Court battle Trump meets with potential Supreme Court pick Amy Coney Barrett at White House Names to watch as Trump picks Ginsburg replacement on Supreme Court MORE.

But it’s not just open seats that are showing signs of trouble for Republicans.

Sen. Ben Sasse Benjamin (Ben) Eric SasseTrump says he'll sign order aimed at protecting premature babies in appeal to religious voters Government watchdog recommends creation of White House cyber director position Chamber of Commerce endorses McSally for reelection MORE (R-Neb.), a conservative who has publicly aired concerns about Trump, has also sparked national chatter about a potential primary fight. The Nebraska Republican has broken with Trump on high-profile issues like withdrawing troops from Syria and lifting sanctions on three Russian companies.

He has also talked publicly about leaving the Republican Party, rhetoric that could raise concerns with many red-state voters.

But a GOP strategist on Wednesday dismissed the chances of a primary fight. And Heye, when asked about competitive races beyond North Carolina, Alabama and Kansas, said he "hadn't heard much" about a primary challenge developing against Sasse.

John Hibbing, a professor of political science at the University of Nebraska-Lincoln, said he was skeptical that Sasse would get a competitive Republican challenger. He noted that early chatter about a high-profile primary fight has died down as Sasse has stuck with Trump on recent fights, including voting against nixing his emergency declaration.

"I think as long as Sasse continues to back the president on those kinds of issues, he'll be fine," Hibbing added.

The group previously tried to unseat Sen. Thad Cochran William (Thad) Thad CochranEspy wins Mississippi Senate Democratic primary Bottom Line Mike Espy announces Mississippi Senate bid MORE (R-Miss.) during the 2014 cycle.

Reports about the group trying to recruit a challenger were met with swift pushback from Senate Republicans, reminiscent of the primary wars from previous cycles.

“Club for Growth had their head handed to them when they challenged Trump in the 2016 presidential primary,” said Jack Pandol, spokesman for the McConnell-aligned Senate Leadership Fund, in a statement this month. “They’ll get the same result here in North Carolina.”

The NRSC and the Senate Leadership Fund have both pledged they won’t work with consultants who work on campaigns challenging a sitting GOP senator, marking part of an effort to dissuade top operatives from joining insurgency challengers.

“Party committees, their job is to protect their incumbent members and to win seats that currently belong to the other party,” Heye said, adding that there was “a lot of frustration ... in past cycles about primarying incumbent members.”

Updated at 12:28 p.m.