A security guard is dead and another is fighting for life after a drive-by shooting outside a nightclub in Melbourne's inner south on Sunday morning.

Key points: A 37-year-old man who worked as a security guard at the venue died in hospital

A 37-year-old man who worked as a security guard at the venue died in hospital Two other security guards and three others were also wounded

Two other security guards and three others were also wounded A black Porsche SUV was seen speeding from the scene and was later found burnt out

Police said at least four people were hit by shots fired from a car into a crowd outside the Love Machine nightclub, near the corner of Little Chapel Street and Malvern Road in Prahran about 3:10am.

Among the victims was 37-year-old security guard and Narre Warren South man Aaron Khalid Osmani, who died in hospital from his injuries.

A Go Fund Me page has been set up to help Mr Osmani's family with funeral costs, which has already raised over $6,000.

"You will be forever remembered for your kindness. You were not just a supervisor but a friend," one donor commented.

Another person who donated said "everyone has the right to go to work and return safe".

Mr Osmani was praised as a great person who would be remembered for his kindness. ( GoFundMe )

Six people received hospital treatment after the shooting, including two other security guards and a patron who was lining up to enter the club.

A 28-year-old man remains in a critical condition in hospital.

A 50-year-old man and a 29-year-old man have non-life-threatening injuries.

Police searched a drain outside the venue. ( AAP: Ellen Smith )

Detective Inspector Andrew Stamper of the homicide squad said investigators had been told a man ran from the scene to Chapel Street, leaving a trail of blood on the footpath.

Police said a 26-year-old man later turned up at hospital with non-life threatening injuries believed to have been sustained in the shooting.

A 20-year-old woman was also injured in the incident.

It was believed she may have fallen at the scene of the shooting and hit her head.

Inspector Stamper declined to detail the injuries of those who were taken to hospital.

"Obviously they're gunshot wounds from fairly close proximity, so horrific injuries," he said.

Inspector Stamper said it was too early to say whether the attack was a targeted one, or whether the shooter had been inside the club earlier.

He said the motive for the attack was unclear.

Police are investigating whether the shooter had earlier been inside the club. ( Facebook: Love Machine )

Detectives will investigate possible links to outlaw motorcycle gangs and other organised crime groups, and any possible connections to other recent shootings.

Over a 10-day period last month, five people were killed in separate shootings in Springvale, Meadow Heights, Dandenong and Kensington.

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Inspector Stamper said the full resources of police would be deployed to find those responsible for the latest shooting.

"We have got a lot of people that are focused on this and we won't stop," he said.

"No stone will be left unturned in terms of finding the people who have carried out this act."



Steve Yousif, who describes himself as a Love Machine host, posted on Facebook that "the love machine family lost a beautiful soul today".

Police are investigating if a black Porsche SUV seen leaving the area is related to the shooting.

Police said the car was later found burnt out in Wollert, in Melbourne's north.

A witness, Daniel, who lives nearby, said he was woken by gunshots.

"I thought it was three gunshots and then there was a bit of screaming and commotion downstairs, so I just stuck my head out the window which looks over Love Machine and then everyone was running around," he said.

He said he saw police with what looked like assault rifles, and heard officers telling people to get out of the way.

He saw paramedics working on three people outside the club before they were taken away in ambulances.

Four men were taken to hospital after the shooting, and one of these men has since died. ( AAP: Ellen Smith )

Forensic police spent this morning searching the footpath and a drain outside the nightclub.

Officers have marked off a large area of the footpath where blood stains can be seen.

Anyone with information is asked to contact Crime Stoppers on 1800 333 000.