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Different cannabis effects different people differently.

Of course, but the same cannabis affects different people differently, too. Why is that? Lots of potential reasons for sure, psychological familiar and tolerance being a couple of obvious ones. However, one reason that may not immediately come to mind is each person’s unique genetic variants and how those genes affect cannabinoid metabolism.

The study of how our genes influence what is or is not healthy for us in medicine, diet, and lifestyle is called nutrigenomics. Today’s episode explores cannabis nutrigenomics, or in other words, how your genes affect your high.

Additionally, with the guest for this episode, David Krantz, we also explore epigenetics (or how the environment and behavior overtime changes our gene behavior) and its connection to cannabis nutrigenomics. How does regular cannabis affect our epigenetic health?

David Krantz is a certified Epigenetic Coach and sought-after expert in the field of individualized genetic-based nutrition and peak performance. As a lifelong musician, David sees the various systems of the body as parts of a complex symphony. And, as a coach, he excels at helping clients fine-tune those parts to create resonant harmonious health and harness their creative and personal power.

An expert in the pharmacogenetics of the endocannabinoid system, David is best known for developing a proprietary genetic test that helps people understand their unique and individual response to cannabinoids. He was nominated in 2019 as a Top 100 Health innovator by the International Forum For Healthcare Advancement. A biohacker by training and artist by nature, David enjoys working with others who have a deep passion for getting the most out of life.

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Episode Breakdown

a general rundown of nutritional genomics and its application in understanding biology

the profound health issues David faced that brought him into nutritional genomics

(special note about the value of understanding polyvagal theory)

the failure of the pre-packed dietary approach, be it veganism, paleo, or low-carb

the endocannabinoid system

the genetic differences of cannabis metabolism between different people

why some people can “smoke weed every day” and make millions, and others can’t get off the couch

how cannabis effects working memory differently in different genetic predispositions in each people based on baseline dopamine levels

how our brain hides from itself

the phenomena of “used to smoke all the time without issues then all of a sudden cannabis creates anxiety and paranoia”

epigenetics and how cannabis changes how our genes express

the genetic variant that increases the chances of developing cannabis-induced psychosis

genetic profiling as a screening platform to understand what medical intervention would be most helpful for specific people

the institutional complications that might prevent the introduction of genetic-specific medical care into the medical infrastructure

how these ideas fit inside the modern context of the climate crisis

how do genetic profiles influence dose-response differences with psychedelics

speculating on the long term epigenetic impact of psilocybin use

speculating on the long term epigenetic impact of therapeutic/healing work

Relevant Links

Learn more about David Krantz and his work with Cannabis Nutrigenomics, including details on how you can have a free 30min consult with him.

Follow David On Instagram and on Facebook