The principal supplier of street level drugs in Kings Cross has been arrested during early morning raids in Sydney's inner east on Tuesday, police will allege.

The 41-year-old woman was one of four people arrested at properties in Darlinghurst, Surry Hills and Redfern, all in connection with the supply of heroin and ice in the Kings Cross area.

Two men, aged 40 and 43, and a 34-year-old woman were also arrested when search warrants were executed at two properties on Darlinghurst Road, Kings Cross about 6am on Tuesday.

The 40-year-old male remained in St Vincent's Hospital on Tuesday afternoon after sustaining a facial injury during the arrest, when it is alleged he became aggressive towards police.