Rodent Research 6 (RR-6): In support of the on-going RR-6 investigation, the crew removed the mice and restocked the rodent habitats with new food bars in addition to cleaning the lids and interiors cages of the habitats. The Rodent Research-6 (RR-6) mission uses mice flown aboard the International Space Station (ISS) and maintained on Earth to test drug delivery systems for combatting muscular breakdown in space or during disuse conditions. RR-6 includes several groups of mice selectively treated with a placebo or implanted with a nanochannel drug delivery chip that administers compounds meant to maintain muscle in low gravity/disuse conditions.

Amyloid Sample Transfer: To prepare for incubation activities tomorrow, today four Amyloid samples were retrieved from the -95 degree Celsius Dewar of the Minus Eighty Degree Celsius Laboratory Freezer for ISS (MELFI) and installed into the +2 degree Celsius Dewar of the MELFI. Amyloid fibril is the protein aggregation that is known to be associated with various diseases including Alzheimer’s disease and diabetes. To develop treatments for Alzheimer’s disease, it is important to elucidate the mechanism of amyloid fibril formation. In this study, aiming to elucidate the mechanism of amyloid fibril formation, we will prepare the high-quality homogeneous amyloid fibrils using microgravity environment, and bring back the samples to characterize the fibrillation process and intermediate structure by NMR and electron microscopic analyses.

Cell Science Validation Bag Change-Out Operations: The crew replaced the Bioculture System Cassette media and sump bags in the MSG with the media and sump bags from an ambient stowage container. After the bags were changed out, the cassettes were transferred back into the Bioculture System. This flight of the Bioculture System is to validate the hardware by testing and checking out its engineering and operational capability to maintain cell cultures for a long duration in the space flight environment on the ISS. Furthermore, the new enabling capabilities and procedures to manually conduct experiments with the specimens cultured in the Bioculture System will be demonstrated. Overall, the validation of the performance of the Bioculture System in the space flight environment is a critical step to insure the success of future space bioscience experiments that will be conducted on ISS using this facility.

Space Test Program – H5 (STP-H5) Innovative Coatings Experiment (ICE): The crew photographed ICE material strips on STP-H5 from the Cupola and Japanese Experiment Module (JEM) windows. The harsh radiation and extreme temperatures of space can corrode the paint and coatings that protect spacecraft exteriors, potentially damaging a spacecraft’s hull. Optical coatings are also important for robotic and human navigators, who would rely on specialized markings to capture or repair spacecraft. The STP-H5 ICE investigation studies new coatings for use on spacecraft in low Earth orbit, determining their stability after 2 years in space. Photographs are taken at 60-day intervals.

Earth Imagery from ISS Target Operations: Using the RED camera, the crew took images of Italy and the Nile Delta. This investigation creates a series of videos, showcasing Earth from space. These videos are taken with cameras on the ISS in 6K hi-resolution, then integrated into videos for screensavers for public enjoyment, exploration, and engagement.

NanoRacks External Platform (NREP)-3: The crew pressurized the Japanese Experiment Module Airlock (JEMAL) and performed a leak check today in preparation for return of the slide table and the (NREP)-3 into the JEM. The Cavalier Space Processor, a passive remote sensor with onboard processing capability, will be installed on the NREP-3, which will be attached to the JEM External Facility next week. NREP represents the first external commercial research capability for testing in support of scientific investigations, sensors, and electronic components in space.

Node 3 Waste and Hygiene Compartment (WHC) Maintenance: The crew removed and replaced the WHC urine receptacle and insert filter. This was nominally planned periodic maintenance.

Mobile Servicing System (MSS) Operations: This afternoon, Ground Controllers will translate the Mobile Transporter (MT) from Worksite 4 (WS4) to WS6 in preparation for Dragon external cargo activities scheduled for the next few days. Once the MT is positioned at WS6, the Space Station Remote Manipulator System (SSRMS) will be configured for external Dragon cargo operations. They will unstow Special Purpose Dexterous Manipulator (SPDM) and setup for Total & Spectral solar Irradiance Sensor (TSIS) extraction from the Dragon trunk. They also will perform a Dragon Trunk Camera checkout and Dragon Trunk cargo survey.

Today’s Planned Activities

All activities are complete unless otherwise noted.



Life On The Station Photo and Video

Preparation of Reports for Roscosmos Web Site and Social Media

SCENARIO. Observations and photography

БВН grille cleaning in Soyuz 734

URAGAN. Observation and photography

ECON-M. Observation and photography

Prepare and activate SM [КСПЭ] camcorder (for TV PAO “QDC Removal” in mpeg2 format

Virus Definition File Update on Auxiliary Computer System [ВКС] Laptops and report

Rodent Research Node 2 Camcorder Video Setup

Daily Planning Conference

JEM Airlock Press

Rodent Research Habitat 1 & 2 Restock

Progress 436 Activation, Air Duct Removal

ISS Crew Orientation

Cell Science Validation Bag Ops Review 2

Soyuz 737 transfer ops, IMS update

ISS CREW/SSIPC CONFERENCE

Removal of Quick Disconnect Screw Clamps in the Docking and Internal Transfer System [ССВП]. SM Aft – Progress 436 interface Video Recording

JEM Airlock Leak Check

SM Aft – Progress 436 (DC) Hatches Close

ПрК-СУ and Progress-СУ Hatch Leak Check

Handover of Increment 54 Crew

[КСПЭ] camcorder, TV-system control hardware deactivation and application shutdown

ИП-1 sensors positioning check

Rodent Research Habitat 3 & 4 Restock

In Flight Maintenance (IFM) Waste and Hygiene Compartment (WHC) Urine Receptacle (UR) and Insert Filter (IF) Remove and Replace

Public Affairs Office (PAO) High Definition (HD) Config JEM Setup

Public Affairs Office (PAO) Event in High Definition (HD) – JEM

Crew time for ISS adaptation and orientation

PROFILAKTIKA-2. Experiment Setup. Tagup with specialists

PROFILAKTIKA-2. Assistance During the Experiment

HRF Generic Frozen Blood Collection Setup

Multi-purpose Small Payload Rack (MSPR) Two-Phase Flow Experiment Equipment Deactivation

PROFILAKTIKA-2. Experiment Ops on БД-2 (MO-3 test in passive mode). Tagup with specialists

PROFILAKTIKA-2. Closeout Ops. Tagup with specialists

Cell Science Validation Glacier Sample Removal

Cell Science Validation Bag Change Out Ops Session2

Amyloid sample Retrieval from MELFI -95 degrees C.

Amyloid sample Insertion into MELFI +2 degrees C.

Environmental Health System (EHS) Total Organic Carbon Analyzer (TOCA) Water Recovery System (WRS) Sample Analysis

Cyclops ICE Experiment Photos

Amyloid Item Gathering

MELFI 3 Ice Brick Retrieve

Microbial Tracking-2 Saliva Setup

Cargo Transfer to Dragon

HRF Generic Urine Collection Setup First Time

Personal CO2 Monitor iPad Data Collection

Filling (separation) of ЕДВ (КОВ) for Elektron or ЕДВ-СВ

Preparation for replacement of low frequency telemetry receiving/processing unit [БПИ НЧ]. Tagup with specialists as necessary

СОЖ Maintenance

APEX-05 Spare Petri Plate Photo

CONTENT. Experiment ops

Soyuz 737 transfer ops with IMS update

Public Affairs Office (PAO) High Definition (HD) Config LAB Setup

Public Affairs Office (PAO) Event in High Definition (HD) – Lab

Health Maintenance System (HMS) Profile of Mood States (POMS) Questionnaire

Crew time for ISS adaptation and orientation

Manufacturing Device Locker Move

Made In Space Fiber Optics Locker and Cable Setup

Environmental Health System (EHS) Total Organic Carbon Analyzer (TOCA) Sample Data Record

Manufacturing Device Locker Move

Dragon Cargo Operations Conference

Completed Task List Activities

None

Ground Activities

All activities are complete unless otherwise noted.



Standard commanding

JEM Airlock Pressurization

Three-Day Look Ahead:

Wednesday, 12/27: 67P Undock, HRF Collections, Arthrospira; JEM Gas Trap, Dragon Cargo Ops, PAO EDU Imagery, MELFI EU Braycote, Crew Handover, APEX-5, Microbial Tracking, JAXA Video Part 3

Thursday, 12/28: Dragon Cargo Ops, EVA SLE Rotation, IFM N2 Nadir Bolt 1-3 R&R, EVA Safer Swap, Cell Science Validation, APEX-5 Harvest, Marrow Air

Friday, 12/29: Dragon Cargo Ops, CIR Ops, NH3 Chip Replacement, HRF Collections, Synthetic Bone, Crew Handover, BRIC LED, Personal CO2 Sensor Cal, EIISS, Cell Science Validation,

QUICK ISS Status – Environmental Control Group: