Three people have been taken to the hospital — two with critical injuries — after an early morning crash Monday in San Francisco’s South of Market neighborhood, authorities said.

The crash, which occurred at 7:21 a.m., involved a pickup truck and a car in the area of 10th and Harrison streets, according to San Francisco police. One of the vehicles was traveling the wrong way on a one-way street.

The accident remains under investigation.

Residents were advised to stay clear of the area. Delays were expected.

Check back for updates.

Michael Cabanatuan is a San Francisco Chronicle staff writer. Email: mcabanatuan@sfchronicle.com Twitter: @ctuan