Arber S.

Barbayannis F.A.

Hanser H.

Schneider C.

Stanyon C.A.

Bernard O.

Caroni P. Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature. 393 : 805-809 View in Article Google Scholar

Augustine R.C.

Vidali L.

Kleinman K.P.

Bezanilla M. Actin depolymerizing factor is essential for viability in plants, and its phosphoregulation is important for tip growth. Plant J. 54 : 863-875 View in Article Google Scholar

Bamburg J.R.

Bernstein B.W. Roles of ADF/cofilin in actin polymerization and beyond. F1000 Biol. Rep. 2 : 62 View in Article Google Scholar

Bamburg J.R.

Bray D. Distribution and cellular localization of actin depolymerizing factor. J. Cell Biol. 105 : 2817-2825 View in Article Google Scholar

Bamburg J.R.

Wiggan O.P. ADF/cofilin and actin dynamics in disease. Trends Cell Biol. 12 : 598-605 View in Article Google Scholar

Bellenchi G.C.

Gurniak C.B.

Perlas E.

Middei S.

Ammassari-Teule M.

Witke W. N-cofilin is associated with neuronal migration disorders and cell cycle control in the cerebral cortex. Genes Dev. 21 : 2347-2357 View in Article Google Scholar

Blanquie O.

Bradke F. Cytoskeleton dynamics in axon regeneration. Curr. Opin. Neurobiol. 51 : 60-69 View in Article Google Scholar

Bradke F.

Dotti C.G. The role of local actin instability in axon formation. Science. 283 : 1931-1934 View in Article Google Scholar

Bradke F.

Dotti C.G. Differentiated neurons retain the capacity to generate axons from dendrites. Curr. Biol. 10 : 1467-1470 View in Article Google Scholar

Bradke F.

Fawcett J.W.

Spira M.E. Assembly of a new growth cone after axotomy: the precursor to axon regeneration. Nat. Rev. Neurosci. 13 : 183-193 View in Article Google Scholar

Bravo-Cordero J.J.

Magalhaes M.A.

Eddy R.J.

Hodgson L.

Condeelis J. Functions of cofilin in cell locomotion and invasion. Nat. Rev. Mol. Cell Biol. 14 : 405-415 View in Article Google Scholar

Brieher W. Mechanisms of actin disassembly. Mol. Biol. Cell. 24 : 2299-2302 View in Article Google Scholar

Chandran V.

Coppola G.

Nawabi H.

Omura T.

Versano R.

Huebner E.A.

Zhang A.

Costigan M.

Yekkirala A.

Barrett L.

et al. A systems-level analysis of the peripheral nerve intrinsic axonal growth Program. Neuron. 89 : 956-970 View in Article Google Scholar

Chen H.

Bernstein B.W.

Bamburg J.R. Regulating actin-filament dynamics in vivo. Trends Biochem. Sci. 25 : 19-23 View in Article Google Scholar

Cho Y.

Sloutsky R.

Naegle K.M.

Cavalli V. Injury-induced HDAC5 nuclear export is essential for axon regeneration. Cell. 155 : 894-908 View in Article Google Scholar

Cho Y.

Shin J.E.

Ewan E.E.

Oh Y.M.

Pita-Thomas W.

Cavalli V. Activating injury-responsive genes with hypoxia enhances axon regeneration through neuronal HIF-1α. Neuron. 88 : 720-734 View in Article Google Scholar

Coles C.H.

Bradke F. Coordinating neuronal actin-microtubule dynamics. Curr. Biol. 25 : R677-R691 View in Article Google Scholar

Conde C.

Arias C.

Robin M.

Li A.

Saito M.

Chuang J.Z.

Nairn A.C.

Sung C.H.

Cáceres A. Evidence for the involvement of Lfc and Tctex-1 in axon formation. J. Neurosci. 30 : 6793-6800 View in Article Google Scholar

Costigan M.

Befort K.

Karchewski L.

Griffin R.S.

D’Urso D.

Allchorne A.

Sitarski J.

Mannion J.W.

Pratt R.E.

Woolf C.J. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci. 3 : 16 View in Article Google Scholar

Curcio M.

Bradke F. Axon regeneration in the central nervous system: facing the challenges from the inside. Annu. Rev. Cell Dev. Biol. 34 : 495-521 View in Article Google Scholar

Dawe H.R.

Minamide L.S.

Bamburg J.R.

Cramer L.P. ADF/cofilin controls cell polarity during fibroblast migration. Curr. Biol. 13 : 252-257 View in Article Google Scholar

Dent E.W.

Gupton S.L.

Gertler F.B. The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb. Perspect. Biol. 3 : a001800 View in Article Google Scholar

Dotti C.G.

Sullivan C.A.

Banker G.A. The establishment of polarity by hippocampal neurons in culture. J. Neurosci. 8 : 1454-1468 View in Article Google Scholar

Eiseler T.

Döppler H.

Yan I.K.

Kitatani K.

Mizuno K.

Storz P. Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot. Nat. Cell Biol. 11 : 545-556 View in Article Google Scholar

Endo M.

Ohashi K.

Sasaki Y.

Goshima Y.

Niwa R.

Uemura T.

Mizuno K. Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. J. Neurosci. 23 : 2527-2537 View in Article Google Scholar

Fawcett J.W. The extracellular matrix in plasticity and regeneration after CNS injury and neurodegenerative disease. Prog. Brain Res. 218 : 213-226 View in Article Google Scholar

Feng G.

Mellor R.H.

Bernstein M.

Keller-Peck C.

Nguyen Q.T.

Wallace M.

Nerbonne J.M.

Lichtman J.W.

Sanes J.R. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron. 28 : 41-51 View in Article Google Scholar

Flynn K.C.

Hellal F.

Neukirchen D.

Jacob S.

Tahirovic S.

Dupraz S.

Stern S.

Garvalov B.K.

Gurniak C.

Shaw A.E.

et al. ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain. Neuron. 76 : 1091-1107 View in Article Google Scholar

Forscher P.

Smith S.J. Actions of cytochalasins on the organization of actin filaments and microtubules in a neuronal growth cone. J. Cell Biol. 107 : 1505-1516 View in Article Google Scholar

Garvalov B.K.

Flynn K.C.

Neukirchen D.

Meyn L.

Teusch N.

Wu X.

Brakebusch C.

Bamburg J.R.

Bradke F. Cdc42 regulates cofilin during the establishment of neuronal polarity. J. Neurosci. 27 : 13117-13129 View in Article Google Scholar

Gomis-Rüth S.

Wierenga C.J.

Bradke F. Plasticity of polarization: changing dendrites into axons in neurons integrated in neuronal circuits. Curr. Biol. 18 : 992-1000 View in Article Google Scholar

Gurniak C.B.

Perlas E.

Witke W. The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev. Biol. 278 : 231-241 View in Article Google Scholar

Gurniak C.B.

Chevessier F.

Jokwitz M.

Jönsson F.

Perlas E.

Richter H.

Matern G.

Boyl P.P.

Chaponnier C.

Fürst D.

et al. Severe protein aggregate myopathy in a knockout mouse model points to an essential role of cofilin2 in sarcomeric actin exchange and muscle maintenance. Eur. J. Cell Biol. 93 : 252-266 View in Article Google Scholar

He Z.

Jin Y. Intrinsic control of axon regeneration. Neuron. 90 : 437-451 View in Article Google Scholar

Hellal F.

Hurtado A.

Ruschel J.

Flynn K.C.

Laskowski C.J.

Umlauf M.

Kapitein L.C.

Strikis D.

Lemmon V.

Bixby J.

et al. Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury. Science. 331 : 928-931 View in Article Google Scholar

Hilton B.J.

Bradke F. Can injured adult CNS axons regenerate by recapitulating development?. Development. 144 : 3417-3429 View in Article Google Scholar

Hilton B.J.

Blanquie O.

Tedeschi A.

Bradke F. High-resolution 3D imaging and analysis of axon regeneration in unsectioned spinal cord with or without tissue clearing. Nat. Protoc. 14 : 1235-1260 View in Article Google Scholar

Hu G.

Huang K.

Hu Y.

Du G.

Xue Z.

Zhu X.

Fan G. Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons. Sci. Rep. 6 : 31851 View in Article Google Scholar

Kaplan A.

Morquette B.

Kroner A.

Leong S.

Madwar C.

Sanz R.

Banerjee S.L.

Antel J.

Bisson N.

David S.

et al. Small-molecule stabilization of 14-3-3 protein-protein interactions stimulates axon regeneration. Neuron. 93 : 1082-1093 View in Article Google Scholar

Kremneva E.

Makkonen M.H.

Skwarek-Maruszewska A.

Gateva G.

Michelot A.

Dominguez R.

Lappalainen P. Cofilin-2 controls actin filament length in muscle sarcomeres. Dev. Cell. 31 : 215-226 View in Article Google Scholar

Kuhn T.B.

Meberg P.J.

Brown M.D.

Bernstein B.W.

Minamide L.S.

Jensen J.R.

Okada K.

Soda E.A.

Bamburg J.R. Regulating actin dynamics in neuronal growth cones by ADF/cofilin and rho family GTPases. J. Neurobiol. 44 : 126-144 View in Article Google Scholar

Kunda P.

Paglini G.

Quiroga S.

Kosik K.

Caceres A. Evidence for the involvement of Tiam1 in axon formation. J. Neurosci. 21 : 2361-2372 View in Article Google Scholar

Lowery L.A.

Van Vactor D. The trip of the tip: understanding the growth cone machinery. Nat. Rev. Mol. Cell Biol. 10 : 332-343 View in Article Google Scholar

McQuarrie I.G.

Grafstein B.

Gershon M.D. Axonal regeneration in the rat sciatic nerve: effect of a conditioning lesion and of dbcAMP. Brain Res. 132 : 443-453 View in Article Google Scholar

Meberg P.J. Signal-regulated ADF/cofilin activity and growth cone motility. Mol. Neurobiol. 21 : 97-107 View in Article Google Scholar

Meberg P.J.

Ono S.

Minamide L.S.

Takahashi M.

Bamburg J.R. Actin depolymerizing factor and cofilin phosphorylation dynamics: response to signals that regulate neurite extension. Cell Motil. Cytoskeleton. 39 : 172-190 View in Article Google Scholar

Mizuno K. Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation. Cell. Signal. 25 : 457-469 View in Article Google Scholar

Moriyama K.

Yahara I. Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are affected differentially by mutations around the actin-binding helix. EMBO J. 18 : 6752-6761 View in Article Google Scholar

Moriyama K.

Yahara I. The actin-severing activity of cofilin is exerted by the interplay of three distinct sites on cofilin and essential for cell viability. Biochem. J. 365 : 147-155 View in Article Google Scholar

Moriyama K.

Iida K.

Yahara I. Phosphorylation of Ser-3 of cofilin regulates its essential function on actin. Genes Cells. 1 : 73-86 View in Article Google Scholar

Neumann S.

Woolf C.J. Regeneration of dorsal column fibers into and beyond the lesion site following adult spinal cord injury. Neuron. 23 : 83-91 View in Article Google Scholar

Neumann S.

Bradke F.

Tessier-Lavigne M.

Basbaum A.I. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation. Neuron. 34 : 885-893 View in Article Google Scholar

Nishita M.

Wang Y.

Tomizawa C.

Suzuki A.

Niwa R.

Uemura T.

Mizuno K. Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. J. Biol. Chem. 279 : 7193-7198 View in Article Google Scholar

O’Connor T.P.

Bentley D. Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ. J. Cell Biol. 123 : 935-948 View in Article Google Scholar

Oh Y.M.

Mahar M.

Ewan E.E.

Leahy K.M.

Zhao G.

Cavalli V. Epigenetic regulator UHRF1 inactivates REST and growth suppressor gene expression via DNA methylation to promote axon regeneration. Proc. Natl. Acad. Sci. USA. 115 : E12417-E12426 View in Article Google Scholar

Oleinik N.V.

Krupenko N.I.

Krupenko S.A. ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A. Oncogene. 29 : 6233-6244 View in Article Google Scholar

Ono S. Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics. Int. Rev. Cytol. 258 : 1-82 View in Article Google Scholar

Pak C.W.

Flynn K.C.

Bamburg J.R. Actin-binding proteins take the reins in growth cones. Nat. Rev. Neurosci. 9 : 136-147 View in Article Google Scholar

Pollard T.D.

Blanchoin L.

Mullins R.D. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu. Rev. Biophys. Biomol. Struct. 29 : 545-576 View in Article Google Scholar

Puttagunta R.

Tedeschi A.

Sória M.G.

Hervera A.

Lindner R.

Rathore K.I.

Gaub P.

Joshi Y.

Nguyen T.

Schmandke A.

et al. PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. Nat. Commun. 5 : 3527 View in Article Google Scholar

Qiu J.

Cai D.

Dai H.

McAtee M.

Hoffman P.N.

Bregman B.S.

Filbin M.T. Spinal axon regeneration induced by elevation of cyclic AMP. Neuron. 34 : 895-903 View in Article Google Scholar

Richardson P.M.

Issa V.M. Peripheral injury enhances central regeneration of primary sensory neurones. Nature. 309 : 791-793 View in Article Google Scholar

Riedl J.

Crevenna A.H.

Kessenbrock K.

Yu J.H.

Neukirchen D.

Bista M.

Bradke F.

Jenne D.

Holak T.A.

Werb Z.

et al. Lifeact: a versatile marker to visualize F-actin. Nat. Methods. 5 : 605-607 View in Article Google Scholar

Rodriguez O.C.

Schaefer A.W.

Mandato C.A.

Forscher P.

Bement W.M.

Waterman-Storer C.M. Conserved microtubule-actin interactions in cell movement and morphogenesis. Nat. Cell Biol. 5 : 599-609 View in Article Google Scholar

Rosenblatt J.

Agnew B.J.

Abe H.

Bamburg J.R.

Mitchison T.J. Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. J. Cell Biol. 136 : 1323-1332 View in Article Google Scholar

Ruschel J.

Bradke F. Systemic administration of epothilone D improves functional recovery of walking after rat spinal cord contusion injury. Exp. Neurol. 306 : 243-249 View in Article Google Scholar

Ruschel J.

Hellal F.

Flynn K.C.

Dupraz S.

Elliott D.A.

Tedeschi A.

Bates M.

Sliwinski C.

Brook G.

Dobrindt K.

et al. Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury. Science. 348 : 347-352 View in Article Google Scholar

Sandner B.

Puttagunta R.

Motsch M.

Bradke F.

Ruschel J.

Blesch A.

Weidner N. Systemic epothilone D improves hindlimb function after spinal cord contusion injury in rats. Exp. Neurol. 306 : 250-259 View in Article Google Scholar

Schaffran B.

Hilton B.J.

Bradke F. Imaging in vivo dynamics of sensory axon responses to CNS injury. Exp. Neurol. 317 : 110-118 View in Article Google Scholar

Schwab M.E.

Strittmatter S.M. Nogo limits neural plasticity and recovery from injury. Curr. Opin. Neurobiol. 27 : 53-60 View in Article Google Scholar

Silver D.J.

Silver J. Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer. Curr. Opin. Neurobiol. 27 : 171-178 View in Article Google Scholar

Sivadasan R.

Hornburg D.

Drepper C.

Frank N.

Jablonka S.

Hansel A.

Lojewski X.

Sterneckert J.

Hermann A.

Shaw P.J.

et al. C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. Nat. Neurosci. 19 : 1610-1618 View in Article Google Scholar

Smith D.S.

Skene J.H. A transcription-dependent switch controls competence of adult neurons for distinct modes of axon growth. J. Neurosci. 17 : 646-658 View in Article Google Scholar

Sun F.

Park K.K.

Belin S.

Wang D.

Lu T.

Chen G.

Zhang K.

Yeung C.

Feng G.

Yankner B.A.

He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 480 : 372-375 View in Article Google Scholar

Takano T.

Xu C.

Funahashi Y.

Namba T.

Kaibuchi K. Neuronal polarization. Development. 142 : 2088-2093 View in Article Google Scholar

Tedeschi A. Tuning the orchestra: transcriptional pathways controlling axon regeneration. Front. Mol. Neurosci. 4 : 60 View in Article Google Scholar

Tedeschi A.

Bradke F. Spatial and temporal arrangement of neuronal intrinsic and extrinsic mechanisms controlling axon regeneration. Curr. Opin. Neurobiol. 42 : 118-127 View in Article Google Scholar

Tedeschi A.

Dupraz S.

Laskowski C.J.

Xue J.

Ulas T.

Beyer M.

Schultze J.L.

Bradke F. The calcium channel subunit Alpha2delta2 suppresses axon regeneration in the adult CNS. Neuron. 92 : 419-434 View in Article Google Scholar

van Beuningen S.F.B.

Will L.

Harterink M.

Chazeau A.

van Battum E.Y.

Frias C.P.

Franker M.A.M.

Katrukha E.A.

Stucchi R.

Vocking K.

et al. TRIM46 controls neuronal polarity and axon specification by driving the formation of parallel microtubule arrays. Neuron. 88 : 1208-1226 View in Article Google Scholar

Van Goor D.

Hyland C.

Schaefer A.W.

Forscher P. The role of actin turnover in retrograde actin network flow in neuronal growth cones. PLoS ONE. 7 : e30959 View in Article Google Scholar

Vartiainen M.K.

Mustonen T.

Mattila P.K.

Ojala P.J.

Thesleff I.

Partanen J.

Lappalainen P. The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. Mol. Biol. Cell. 13 : 183-194 View in Article Google Scholar

Wang Y.

Shibasaki F.

Mizuno K. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. J. Biol. Chem. 280 : 12683-12689 View in Article Google Scholar

Weng Y.L.

Wang X.

An R.

Cassin J.

Vissers C.

Liu Y.

Liu Y.

Xu T.

Wang X.

Wong S.Z.H.

et al. Epitranscriptomic m(6)A regulation of axon regeneration in the adult mammalian nervous system. Neuron. 97 : 313-325 View in Article Google Scholar

Witte H.

Neukirchen D.

Bradke F. Microtubule stabilization specifies initial neuronal polarization. J. Cell Biol. 180 : 619-632 View in Article Google Scholar

Ylera B.

Ertürk A.

Hellal F.

Nadrigny F.

Hurtado A.

Tahirovic S.

Oudega M.

Kirchhoff F.

Bradke F. Chronically CNS-injured adult sensory neurons gain regenerative competence upon a lesion of their peripheral axon. Curr. Biol. 19 : 930-936 View in Article Google Scholar