Police have charged a man with murder over the stabbing death of a man in Fitzroy at the weekend.

Homicide squad detectives charged a 25-year-old man from Preston with murder following the death of Shaun Wright in Fitzroy on Sunday.

Police block traffic on Johnston Street, Fitzroy at the weekend. Credit:Ben Millar

The man is expected to appear in the Melbourne Magistrates Court on Wednesday afternoon.

Police also charged a 20-year-old Burnside woman with one count of affray on Wednesday afternoon.