ORIGINAL ARTICLE Pemphigus Vulgaris and Foliaceus IgG Autoantibodies Directly Block Heterophilic Trans-Interaction Between Desmoglein and Desmocollin FREE

Ishii et al. demonstrate that pathogenic autoantibodies that are reactive with desmogleins 1 and 3 and are obtained from patients with pemphigus vulgaris and pemphigus foliaceus sterically inhibit heterophilic trans-interactions between desmogleins and desmocollins. This causes physical desmosome disruption, which leads to the observed skin-blistering phenotype in these patients. .

ORIGINAL ARTICLE Murine Epidermal Ceramide Synthase 4 is a Key Regulator of Skin Barrier Homeostasis FREE

Peters et al. provide evidence that lipid homeostasis underlies maintenance of adult skin barrier function and demonstrate that ceramide synthase 4 is essential for skin barrier maintenance, but not skin barrier establishment. To learn more about the techniques used in this paper, visit the Research Techniques Made Simple article

ORIGINAL ARTICLE The Role of Teledermatology and Teledermascopy in the Diagnosis of Actinic Keratosis and Field Cancerization FREE

Sola-Ortigosa et al. report that teledermoscopy is superior to primary care physician diagnosis as well as to teledermatology for the diagnosis of atrophic, pigmented, and type I and II actinic keratoses. They suggest that when it is used in a gatekeeper health care system, this methodology may nearly reproduce the accuracy of face-to-face diagnoses by dermatologists. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article

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