USA TODAY Sports

Indianapolis Colts (1-2) vs. Jacksonville Jaguars (0-3) in London

TV: Sunday, 9:30 a.m. ET, CBS (Greg Gumbel, Trent Green, Jamie Erdahl)

Line: Colts by 2

Story lines: QB Andrew Luck and the Colts flirted with disaster again but ultimately defeated the San Diego Chargers in another fourth-quarter thriller to avoid falling into their first 0-3 hole since 2011. The defense finally managed to hold a team under 30 points, and that was the difference. ... After opening with a loss to the Green Bay Packers, the Jaguars were blown out in San Diego. They hosted the Baltimore Ravens in Week 3 and had victory in their sights until a blocked field goal try led to a 19-17 loss. QB Blake Bortles was sacked four times. A win might silence calls for coach Gus Bradley’s job.

Fantasy football rankings: Week 4

Tennessee Titans (1-2) at Houston Texans (2-1)

TV: Sunday 1 p.m. ET, CBS (Tom McCarthy, Adam Archuleta)

Line: Texans by 6

Story lines: Hosting an Oakland Raiders defense that was the first in 49 years to allow 500 yards of offense in its first two games, Tennessee couldn’t even get to 400. In their 17-10 Week 3 loss, the Titans moved the ball effectively but had three costly turnovers. QB Marcus Mariota threw two picks and fumbled twice (losing one), squandering a dazzling performance from the offensive line and RB DeMarco Murray (114 yards rushing and a TD, plus 41 yards on five catches). They’ll need more from Mariota to upset Houston on the road, though he may still be without TE Delanie Walker. ... With DE J.J. Watt going on injured reserve, the Texans’ D-line will continue to struggle. Houston got punched in the mouth again by the New England Patriots last week 27-0, its first shutout since 2003. QB Brock Osweiler has taken much of the blame, but the offensive line got manhandled in the loss and will be without LT Duane Brown again.

Duke Johnson heads this week's list of deep fantasy sleepers

Cleveland Browns (0-3) at Washington Redskins (1-2)

TV: Sunday 1 p.m. ET, CBS (Kevin Harlan, Rich Gannon, Stacey Dales)

Line: Redskins by 8

Story lines: The winless Browns have been competitive in two heartbreaking losses, but it’s not about moral victories. Considering Cleveland already had one of the league’s youngest rosters before losing its top two quarterbacks and several other starters to injuries, progress is being made. Rookie QB Cody Kessler wasn’t great but got more confident as the game went on, and the Browns turned to WR Terrelle Pryor as a quarterback, running back and playmaker all over the field. The young defense is still susceptible to big plays. ... Last weekend’s win at the New York Giants was likely a must for Washington to stay in the NFC East race. QB Kirk Cousins passed for 296 yards and two TDs, and a defense that’s been far from great delivered in the biggest moments. The Redskins still need more out of their running game, but this weekend should see the chance to score a bunch of points and climb back to .500.

Start or sit: Can Blake Bortles get back on track?

Seattle Seahawks (2-1) at New York Jets (1-2)

TV: Sunday, 1 p.m. ET, Fox (Kevin Burkhardt, John Lynch, Pam Oliver)

Line: Seahawks by 1½

Story lines: While Seattle’s offense finally got on track last Sunday, the defense has this team back on the radar as an NFC front-runner. That could be a big factor this weekend. The only thing that has slowed this team has been the health of QB Russell Wilson. First an ankle injury, then a sprained medial collateral ligament in his left knee in the win vs. the San Francisco 49ers. Coach Pete Carroll said he planned to play Wilson, who wasn't even listed on the final injury report. RB Thomas Rawls could miss a few weeks with a broken leg, but RB Christine Michael stepped in to rush for 106 yards and two TDs. ... New York’s humbling loss to the Kansas City Chiefs last weekend might be the worst performance of coach Todd Bowles’ tenure. QB Ryan Fitzpatrick threw six interceptions, one short of the NFL record, in the eight-turnover fiasco. The Jets need a quick turnaround but won't have WR Eric Decker (shoulder).

USA TODAY Sports' Week 4 NFL picks: Big games in Pittsburgh, Minnesota

Buffalo Bills (1-2) at New England Patriots (3-0)

TV: Sunday 1 p.m. ET, CBS (Ian Eagle, Dan Fouts, Evan Washburn)

Line: Patriots by 4

Story lines: The Bills ended a two-game losing streak with a 33-18 upset of the Arizona Cardinals with a dominating defense, sacking QB Carson Palmer five times and intercepting four passes. CB Stephon Gilmore had two interceptions and four pass breakups. RB LeSean McCoy rushed for 110 yards, and QB Tyrod Taylor added 76 yards on nine carries, including a 49-yard run, longest by a quarterback in Bills history. ... Coach Bill Belichick has guided New England to an unbeaten start despite missing suspended QB Tom Brady and having limited use of injured TE Rob Gronkowski (questionable/hamstring). Belichick has deftly shuffled reserve quarterbacks because of injuries. It’s uncertain whether Jimmy Garoppolo, Jacoby Brissett or WR Julian Edelman (quarterback at Kent State) will start. Belichick will have Brady and suspended LB Rob Ninkovich back next weekend.

Why do Patriots keep winning? Hall of Fame coaches explain Bill Belichick's success

Carolina Panthers (1-2) at Atlanta Falcons (2-1)

TV: Sunday, 1 p.m. ET, Fox (Dick Stockton, Chris Spielman, Kristina Pink)

Line: Panthers by 3

Story lines: The Panthers’ O-line was overpowered in passing situations vs. the Minnesota Vikings, leaving QB Cam Newton few downfield options and often defenseless in the pocket. That likely won’t happen against the pass-rush-challenged Falcons, though losing LT Michael Oher (concussion) this week doesn't help. If the Panthers can’t protect Newton better against the league’s top-tier teams, then a return trip to the Super Bowl is a pipe dream. ... Atlanta can expect to see a refocused Carolina team in the Georgia Dome, where the Panthers are 2-6 in their last eight visits. That includes a 20-13 loss last season in Week 16 that ended the Panthers’ 15-game winning streak.

Where did Colin Kaepernick get start as an activist?

Oakland Raiders (2-1) at Baltimore Ravens (3-0)

TV: Sunday, 1 p.m. ET, CBS (Andrew Catalon, Steve Tasker, Steve Beuerlein, Chris Fischer)

Line: Ravens by 3

Story lines: The defense is still finding its way, but the Raiders remain a young team with room to grow. Last weekend’s win at Tennessee featured a much-improved defensive effort. If the Raiders can play good defense and run the ball effectively, they trust that QB Derek Carr, WR Amari Cooper and WR Michael Crabtree will make big plays in big spots. The Raiders are playing their third road game in four weeks. Will they have enough left in the tank to win this one in the fourth quarter? ... The Ravens are enjoying their return to first place after being devastated by injuries last season. QB Joe Flacco has been his usual steady self, and the defense hasn’t been great but has delivered solid second-half performances to preserve wild wins the last two weeks. But the run game will have to improve despite a battered O-line.

Detroit Lions (1-2) at Chicago Bears (0-3)

TV: Sunday, 1 p.m. ET, Fox (Kenny Albert, Daryl Johnston, Laura Okmin)

Line: Lions by 3

Story lines: The Lions have a top-five scoring offense and bottom-five scoring defense. QB Matthew Stafford and WR Marvin Jones might have the NFL’s hottest connection, but the defense’s inconsistent pass rush (still without injured DE Ziggy Ansah) and inability to generate takeaways are major issues. The running game has been ineffective. ... The Bears sit 0-3 for the second consecutive season, with an NFL-worst minus-38 point differential. With QB Jay Cutler (thumb) injured, backup Brian Hoyer moved the offense, but not until his team faced a 24-3 halftime deficit. Missing NT Eddie Goldman, ILB Danny Trevathan, nickel Bryce Callahan and others, the defense was gashed.

Denver Broncos (3-0) at Tampa Bay Buccaneers (1-2)

TV: Sunday, 4:05 p.m. ET, CBS (Spero Dedes, Solomon Wilcots)

Line: Broncos by 3

Story lines: In his first big road test, Broncos QB Trevor Siemian passed with flying colors in a 29-17 win at the Cincinnati Bengals. Trailing 17-16 in the fourth quarter, the Broncos finished drives of 82 and 83 yards with Siemian TD passes. Siemian passed for 312 yards and four TD passes. The defense stepped up again, stopping two fourth-quarter possessions with a three-and-out and an interception by S Will Parks. ... Tampa Bay found a way to lose its home opener to the Los Angeles Rams 37-32, despite having far more first downs (30-18) and yards (472-320). Big plays doomed the Bucs. The defense allowed TD passes of 43 and 44 yards, along with a crucial 77-yard fumble return by Rams DE Ethan Westbrooks. QB Jameis Winston, who fumbled on a key sack late, passed for 405 yards, but the running game was spotty with Doug Martin out.

Los Angeles Rams (2-1) at Arizona Cardinals (1-2)

TV: Sunday, 4:25 p.m. ET, Fox (Thom Brennaman, Charles Davis, Peter Schrager)

Line: Cardinals by 8

Story lines: The Rams are on a two-game win streak after their Week 1 disaster vs. the Niners. QB Case Keenum did enough Sunday to quiet the calls for Jared Goff. RB Todd Gurley finally started to make an impact, and the defense had issues but was able to make a red-zone stand when it counted. ... Considering the Rams have given the Cardinals fits and Arizona’s October schedule includes consecutive games against Seattle and Carolina, it wouldn’t be shocking to see the Cards’ wheels start to come off heading into their Week 9 bye. QB Carson Palmer threw four interceptions and was sacked five times in the Week 3 loss to Buffalo, and Arizona fared no better on defense.

New Orleans Saints (0-3) at San Diego Chargers (1-2)

TV: Sunday, 4:25 p.m. ET, Fox (Chris Myers, Ronde Barber, Jennifer Hale)

Line: Chargers by 4

Story lines: QB Drew Brees,San Diego’s second pick (32nd overall) in the 2001 draft, is 37 and in his 11th season with New Orleans. He still plays at a Hall of Fame level and has every intention of playing into his 40s. He passed for 376 yards and three TDs Monday, but his team fell 45-32 to the Falcons. New Orleans ranks second to last in yards and points allowed. ... San Diego could be 3-0 but instead finds itself in last place in the AFC West at 1-2 after blowing late leads against the Kansas City Chiefs and Indianapolis. Losing close games has become a way of life for coach Mike McCoy, who is 3-11 in games decided by eight points or fewer since last season. ... Both teams have beaten-up offensive lines.

Dallas Cowboys (2-1) at San Francisco 49ers (1-2)

TV: Sunday, 4:25 p.m. ET, Fox (Joe Buck, Troy Aikman, Erin Andrews)

Line: Cowboys by 3

Story lines: Rookie QB Dak Prescott continues to make Dallas’ fan base forget about Tony Romo. While it’s unlikely Prescott will remain the starter when Romo returns from his back injury, he was again flawless in last weekend’s easy win against the Bears, throwing for one TD and running for another. He hasn’t thrown an interception. But Dallas likely won't have WR Dez Bryant (knee) Sunday. ... The Niners are coming off back-to-back 19-point losses. The defense has been trampled, allowing 83 points and 947 yards to the Panthers and Seahawks, and coach Chip Kelly’s offense has looked even more ghastly than it did in his final days with the Eagles. That’s not all his fault, though. QB Blaine Gabbert threw for 119 yards and had a 51.9 passer rating vs. Seattle. That sparked speculation that Colin Kaepernick could find his way back in the lineup.

Kansas City Chiefs (2-1) at Pittsburgh Steelers (2-1)

TV: Sunday, 8:30 p.m. ET, NBC (Al Michaels, Cris Collinsworth, Michele Tafoya)

Line: Steelers by 5½

Story lines: The Chiefs became a takeaway machine at home, forcing the Jets into eight in a 24-3 win Sunday. They intercepted QB Ryan Fitzpatrick six times, five on the Jets’ final five possessions, and three were in the end zone. One was returned 55 yards for a TD by LB Derrick Johnson. Kansas City QB Alex Smith rebounded from the 68.1 passer rating with a rating of 105.2. RB Jamaal Charles (knee) may finally play Sunday. ... The experienced Steelers were expected to burst Eagles rookie QB Carson Wentz’s bubble, but it never came close to happening in a 34-3 Philadelphia win. Wentz passed for 301 yards and two TDs, while Ben Roethlisberger was sacked four times. Pittsburgh’s defense couldn’t stop rookie RB Wendell Smallwood and Kenjon Barner, who combined for 121 yards.

New York Giants (2-1) at Minnesota Vikings (3-0)

TV: Monday, 8:30 p.m. ET, ESPN (Sean McDonough, Jon Gruden, Lisa Salters)

Line: Vikings by 4½

Story lines: New York might have played its most complete game of the season last weekend and held Washington without a touchdown on four possessions inside the red zone. But the Giants lost because of a sloppy, undisciplined performance. They committed 11 penalties for 128 yards, turned the ball over three times and gave up a 31-yard pass on a fake punt. RB Shane Vereen will need season-ending surgery on his triceps. ... The Vikings rolled over the defending NFC champion Panthers on the road, sacking Cam Newton eight times and forcing four turnovers. Minnesota is using what might be the NFL’s best defense to take pressure off a battered offense missing injured RB Adrian Peterson, QB Teddy Bridgewater and LT Matt Kalil.

Byes: Green Bay Packers, Philadelphia Eagles

PHOTOS: Week 4 games ranked by watchability