SAN FRANCISCO -- Carlos Santana didn't leave his heart in San Francisco on Friday night, but he did leave a potential Indians victory in the rubble of his performance at AT&T Park.

After hitting a two-run double in the first inning, Santana made two errors at first base in the sixth and was picked off first base in the eighth as the Giants rallied to beat the Indians, 4-3, in front of a soldout crowd of 41,690 fans.

To make the loss sting even more, Indians right fielder Shin-Soo Choo left the game in the fourth inning with a broken left thumb after being hit on the left hand by a Jonathan Sanchez pitch. He was placed on the 15-day disabled list after the game.

"Losing Choo is a big blow for us," said manager Manny Acta. "He means so much to us not only offensively, but defensively and running the bases. He's a very important part of our lineup. Especially the way he was coming on with the bat the last couple of weeks."

Acta didn't know how long Choo would be on the disabled list. He was still at the hospital being examined when the game ended. He also suffered a cut on the thumb from the pitch that deflected off his hand and hit him in the batting helmet.

The Giants entered the sixth trailing Carlos Carrasco, 3-1, but that was before Santana's first baseman's glove deserted him. Santana, the Indians' regular catcher, is scheduled to see most of the playing time at first on this nine-game interleague trip against the Giants, Diamondbacks and Reds. Friday was Santana's 19th start at first this year.

"It was a bad night, but tomorrow is a new day," said Santana. "I'm going to come to the park with a lot of energy and try to help this team win."

Chris Stewart started the inning with a single to left. Pinch-hitter Nate Schierholtz sent a chopper to Santana. He made a leaping catch, but his throw to second for the force got past Asdrubal Cabrera for his first error to put runners on first and second.

"The throw to second base, I have seen Asdrubal catch tougher balls, but it wasn't a good throw," said Acta.

Andres Torres singled to center to load the bases. Emmannuel Burris followed with a slow roller to first. Santana charged the ball with the intention of going home for the force, but didn't handle it cleanly as Stewart scored to make it 3-2. That was error No.2.

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"On the ball coming in, he had a chance to pick it and get the force at the plate," said Acta. "He just bobbled it."

Pablo Sandoval tied it at 3 with a sacrifice fly to right as Torres advanced to third. Aubrey Huff sent a foul pop down the left-field line. Jack Hannahan, backpedaling on the ball, made the catch, but couldn't make a strong throw home as Torres scored for a 4-3 lead.

Carrasco (7-4, 3.62) finally ended the inning by retiring Pat Burrell on a fly ball to center. All three San Francisco runs were unearned. Carrasco's first complete game of the season came with four strikeouts. He allowed six hits.

"I was impressed with Carrasco in that inning," said Acta. "He didn't crumble. He could have given up a ton of runs and lose his concentration. He just kept his composure and went after hitters and kept the game at 4-3.

"He's maturing fast as a pitcher and we're happy to see that."

Indians meet Giants on the West Coast 6 Gallery: Indians meet Giants on the West Coast

Santana's two-run double in the first off Sanchez gave the Indians the early 2-0 lead. Orlando Cabrera and Asdrubal Cabrera walked in front of Santana and scored on his drive to the wall in left center. Sanchez leads the NL in walks with 59.

Carrasco, trying to win his fourth consecutive start, faced the minimum in the first three innings. Torres started the game with a bunt single, but catcher Lou Marson threw him out on an attempted steal of second. Marson has thrown out 54 percent (15-for-28) of the runners who have tried to steal against him.

Hannahan pushed the Tribe lead to 3-0 with a RBI single in the fourth. It was only his third RBI in June and his sixth in the last two months. But that hit -- only the Indians' second of the night -- was their last of the night.

Torres gave the Giants their first run with a leadoff homer in the fourth. He hit Carrasco's 3-2 pitch.

Sanchez allowed three runs on two hits in 4 2/3 innings. He walked six and struck out six, but the Indians didn't make the most of the runners he put on base. In his second start against the Indians, Sanchez thew 94 pitches, including 49 for strikes.

Brian Wilson pitched the ninth for his 22nd save. Santiago Casilla (1-1), who relieved Sanchez in the fifth, earned the victory.

Cinesport video: Giants 4, Indians 3

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