Border Patrol agents in the US have seized a nearly 45kg bundle of marijuana after spotting it flying over the Mexican border fence.

Surveillance video on Wednesday (Thursday NZ Time) captured the large package launching through the air over the fence from Mexico into southern Arizona. Agents on the ground found a large, plastic-wrapped bundle worth about US$48,000 (NZ$66,000).

Spokeswoman Stephanie Dixon said drug smugglers were increasingly launching massive bundles of pot over the border fence, posing a danger to nearby residents and businesses because of the weight of the bundles. She said she knew of one incident in which a bundle went through the roof of a dog house.

It's unclear what smugglers used to launch this particular package, but in the past they've used home-made catapults and air cannons.

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