At least two people have been killed and more than a dozen others wounded in a shooting at a nightclub in Fort Myers, Florida.

A shooting at a Florida nightclub early Monday morning (Monday afternoon NZ Time) killed two people and wounded at least 17, police said.

The attack apparently occurred at a teen party, billed as a "Swimsuit Glow Party," at Club Blu in Fort Myers, according to local media.

Police detained three people and said the area around the club had been deemed safe, police Captain Jim Mulligan said in a statement.

Stephanie Tinoco/TWITTER Two are reported dead and up to 17 injured after a shooting at a nightclub in Fort Myers, Florida, US.

It was not immediately clear what triggered the violence.

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Two people have been shot dead at a Florida nightclub.

Three people remained hospitalised Monday morning, Cherly Garn, a spokeswoman for Lee Memorial Health System, said in an email. All others were treated and released. Two people brought to two other area hospitals were also treated and released, Garn said.

Ages of the patients ranged from 12 to 27, Garn said.

The club is in a strip mall that includes a daycare centre and is across the street from a large apartment complex. Officers had the area taped off as crime scene technicians scoured the strip mall parking lot for clues.

The shooting comes more than a month after a nightclub shooting in Orlando that was the deadliest shooting in modern US history. The shooting at the Pulse nightclub on June 12 left 49 victims dead and 53 others wounded.

The violence at Club Blu erupted about 12:30am on Monday (4.30pm NZ Time), Mulligan said. There were two active crime scenes, police said. Several hours later a street in the area remained closed as police investigated.

In a statement, authorities said the Fort Myers police and the Lee County Sheriff's Office were "actively canvassing the area looking for other persons who may be involved in this incident."

The names of the victims were not immediately available.