AURORA, Colo. (July 24, 2019) - Physicians in the United States may prescribe opioids more frequently to patients during hospitalization and at discharge when compared to their physician peers in other countries, according to a recently published study led by researchers from the University of Colorado School of Medicine.

The study reviewed prescribing practices at 11 academic hospitals in eight countries - the United States, Canada, Spain, Italy, Taiwan, South Korea, the United Kingdom, and New Zealand. The four hospitals in the United States were the University of Colorado Hospital, Denver Health, Hennepin Healthcare in Minneapolis, and Legacy Health in Portland, Oregon.

"Compared with patients hospitalized in other countries, a greater percentage of those hospitalized in the US were prescribed opioid analgesics both during hospitalization and at the time of discharge, even after adjustment for pain severity as well as several other factors like how ill the patients were," wrote the authors of the article that was published online today in the Journal of Hospital Medicine.

The first author of the article is Marisha Burden, MD, associate professor of medicine at the CU School of Medicine and head of the Division of Hospital Medicine.

The study is important because the epidemic misuse of opioid medications has led to addiction and premature death in many communities across the country.

For the newly published study, the researchers approached 1,309 eligible patients and 981 of them consented to the study. Five hundred three were in the United States and 478 were from other countries. Seventy-nine percent of the patients in U.S. hospitals who experienced pain were prescribed opioids during hospitalization, compared with 51 percent of patients at the sites in other countries.

In addition to prescribing practices, the authors note that the patients' perception of pain and the cultural biases toward pain medication may have affected the prescribing practices.

"While we observed that physicians in the US more frequently prescribed opioid analgesics during hospitalizations than physicians working in other countries, we also observed that patients in the US reported higher levels of pain during their hospitalization," Burden and her co-authors wrote. "Our study also suggests that reducing the opioid epidemic in the US may require addressing patients' expectations regarding pain control in addition to providers' inpatient analgesic prescribing patterns."

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Twenty-five authors are listed on the article. In addition to Burden, members of the CU School of Medicine faculty who are authors are Angela Keniston, MSPH; Mary Anderson Wallace, MD; John M. Cunningham, MD; Anna Munoa, MD; Jeffrey Spence, MD; Lindsay Thurman, MD; and Richard K. Albert, MD.

About the University of Colorado School of Medicine

Faculty at the University of Colorado School of Medicine work to advance science and improve care. These faculty members include physicians, educators and scientists at UCHealth University of Colorado Hospital, Children's Hospital Colorado, Denver Health, National Jewish Health, and the Veterans Affairs Eastern Colorado Health Care System. The school is located on the Anschutz Medical Campus, one of four campuses in the University of Colorado system.