A Gold Coast tradie has been left fighting for life after he was ambushed by up to 13 people in a road rage attack on the Gold Coast.

Brock Prime, 29, was assaulted with an "unknown weapon" after he pulled over at Yatala and was confronted by a van-load of men about 9.45pm yesterday.

Police found Mr Prime in a "seriously injured state" and rushed him to hospital, where he remains fighting for life.

Brock Prime is fighting for life after a road rage attack on the Gold Coast. (Instagram)

"Two vehicles came close to a collision somewhere about the Coomera area, those vehicles were a black Subaru Forester wagon and a white van," Detective Inspector Mark Thompson told reporters this morning.

"Subsequent to that near-collision, the two vehicles continued northbound on the highway and entered into what could be described as a game of cat and mouse, swerving in and out of traffic with the van following the black Subaru."

"Witnesses have said that they believe the victim was being struck with an implement, but at this stage we have not confirmed what that implement was," he added.

As many as 13 people may have been travelling in the van, which left the scene before emergency services arrived.

Mr Prime remains in critical condition with life-threatening injuries at the Gold Coast University Hospital.

His family and friends have used social media to appeal for information to help find the "cowards".

"What is the Gold Coast coming to," Haley Gibson wrote.

"Sending my prayers and thoughts to Brock Prime and his loved ones."

A man suffered life-threatening head injuries in an assault on the M1 between Yatala and Pimpama. (9NEWS)

The man was assaulted with an "unknown weapon" on the M1 between Yatala and Pimpama. (9NEWS)

Police want anyone with dascham footage taken on on the M1 between Yatala and Pimpama at the time to come forward. (9NEWS)

Police have appealed for any witnesses or anyone with dashcam footage taken in the area between 9.30pm and 9.45pm to contact them.