By Ryan Dunleavy | NJ Advance Media for NJ.com

No matter what happens in the first 14 games of the 2018 season, Giants quarterback Eli Manning can do something he never has done before in Week 16: Beat the Colts.

The Colts are one of two teams in the NFL that Manning has not defeated during his 14-year Hall of Fame career. Which is the other team that always has his number?

Which team does he have the most wins against? The most touchdown passes? The most yards?

Which team has never intercepted him?

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Ryan Dunleavy | NJ Advance Media for NJ.com

With an assist from ProFootballReference.com, NJ Advance Media has sorted Manning's career by opponents, organized in order from his best regular-season winning percentage to his worst.

Manning's career record as a starter in the regular season is 111-103, plus two appearances off the bench as a rookie behind starter Kurt Warner in 2004.

Scroll to the end for a breakdown of what the numbers mean against the 2018 schedule:



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Raiders (3-0)

Next meeting: 2021

Manning's streak of 210 consecutive starts ended last season when the Giants started Geno Smith in a 24-17 loss to the Raiders. General manager Jerry Reese and coach Ben McAdoo were fired the next day, and Manning was reinstated as the starting quarterback for the final month of a 3-13 season. He also came out of a game against the Raiders due to injury in 2009, but already had built a dominant first-half lead.

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Tim Farrell | NJ Advance Media for NJ.com

Dolphins (3-0)

Next meeting: 2019

Manning has beaten the Dolphins in three stadiums over two different continents, with wins at MetLife Stadium (2011), Sun Life Stadium (2015) and in Wembley Stadium in London (2007). His 67.3 completion percentage against the Dolphins is the best against any opponent, and the Dolphins are the only opponent never to intercept Manning.

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Bills (3-0)

Next meeting: 2019

Playing in rain, sleet and snow, the Giants clinched a playoff spot with a Week 16 win at Buffalo in 2007 (despite just seven completions from Manning) and went on to win the Super Bowl.

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Chris Faytok | The Star-Ledger

Texans (3-0)

Next meeting: Sept. 23 in Houston

The Texans beat the Giants for their win as an expansion franchise in 2002 but will look to best Manning for the first time in Week 3 of this season.

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Rams (5-1)

Next meeting: TBD

Manning was 5-0 against the Rams — including a win in London and three games with 37 or more points scored — until arguably the on-field low point of the 2017 season: A defensive no-show 51-17 loss by the Giants at home as they fell to 1-7.

Manning's 14:2 touchdown-to-interception ratio against the Rams is his best against any opponent.

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Buccaneers (4-1)

Next meeting: Nov. 18 in East Rutherford

Another team that was winless against Manning until 2017, when they beat the Giants on a last-second field goal in Week 4. Manning earned a playoff win against the Buccaneers to start the run to his first Super Bowl ring. He also threw for a career-high 510 yards in a 2012 shootout win against Josh Freeman.

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Chiefs (3-1)

Next meeting: 2021

Manning beat the Chiefs, 12-9 in overtime, for their Giants' win in 2017 against a playoff team. It avenged a loss in 2013 to his old nemesis, coach Andy Reid who went from the Eagles to the Chiefs.

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Will Odell Beckham contract force Giants' hand on Eli Manning?

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John Munson | NJ Advance Media for NJ.com

Redskins (18-9)

Next meeting: Oct .28 in East Rutherford

Manning has more wins at the Redskins' expense than any other team in the NFL even though he only has 29 career touchdown passes (compared to 25 interceptions) in 27 games. Strange but true: Three of his six career rushing touchdowns are against the Redskins.

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Lions (4-2)

Next meeting: 2019

Manning won his first two meetings with the Lions and picked up an overtime win in 2013, but he lost the 2017 home-opener as his offense sputtered to a an 0-2 start with one touchdown in two games.

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Browns (2-1)

Next meeting: 2020

The defending Super Bowl champion Giants were 4-0 and on the way to 11-1 when they lost to the Derek Anderson-quarterbacked Browns, 35-14, in 2008. It seemed another shocker was in store in 2012, when the Browns jumped up 14-0, but Manning led the Giants to 20 second-quarter points and a 41-27 win.

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Jets (2-1)

Next meeting: 2019

The Giants' win on Christmas Eve 2011 included a 99-yard touchdown pass from Manning to Victor Cruz and launched the Giants on their way to Manning's second Super Bowl ring. Manning suffered his first loss to the Jets in overtime in 2015.

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49ers (5-3)

Next meeting: Nov. 12 in San Francisco

One of Manning's signature performances was when he threw 52 passes to lead an overtime upset in the 2011 NFC Championship Game. He won his first three regular-season games against the 49ers, too. But the Giants lost to the winless 49ers in November of last season. He also had a five-interception game in a 2014 loss.

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John Munson | NJ Advance Media for NJ.com

Bears (3-2)

Next meeting: Dec. 2 in East Rutherford

Manning led the Giants to a second-half comeback win when these teams last met in 2016. He has won three of the last four against the Bears.

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Panthers (4-3)

Next meeting: Oct. 7 in Carolina

Manning's first meeting with the Panthers was his first playoff game, and it resulted in a 23-0 shutout loss. He has had the upper hand since then, despite some blowout losses like 41-9 in 2009 and 38-0 in 2013.

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Falcons (4-3)

Next meeting: Oct. 22 in Atlanta

Manning made his first career start (a 14-10 loss that included a touchdown pass to Jeremy Shockey) against the Falcons as a rookie in 2004. He won his next four meetings with the Falcons, including one in the NFC Wild Card Playoffs in 2007 and two in the Georgia Dome.

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Cardinals (3-3)

Next meeting: TBD

The Giants trailed by 11 points with less than four minutes remaining in 2011, but Manning threw two touchdown passes for one of his best career regular-season comebacks. He has lost both meetings to the Cardinals since then, including a Week 16 shutout last season.

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Tony Kurdzik | The Star-Ledger

Ravens (2-2)

Next meeting: 2020

Manning was 4-of-18 for 27 yards and benched against the Ravens as a rookie starter in 2004. He has won two of three since then, including a thriller in 2016 when he hit Odell Beckham for a go-ahead 66-yard catch-and-run touchdown in the final two minutes.

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Bengals (2-2)

Next meeting: 2020

Manning has alternated loss, win, loss, win against the Bengals, including an overtime win in 2008 and a one-point win courtesy of a 3-yard touchdown pass to Sterling Shepard with 55 seconds remaining in 2016.

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Broncos (2-2)

Next meeting: 2021

One of Manning's earliest fourth-quarter comebacks was to overcome a 13-point deficit against the Broncos in 2005, capping the rally with a touchdown pass to Amani Toomer with five seconds on the clock. He also beat the Broncos in Denver for the first time to get the Giants their first win of 2017.

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Cowboys (13-14)

Next meeting: Sept. 16 in Dallas

Manning earned his first win and his first game-winning drive in the 2004 season finale against the Cowboys. He has thrown 49 touchdowns compared to 28 interceptions, including some shining moments.

He won at Dallas in the playoffs in 2007 to set up his first Super Bowl and swept Dallas in two December regular-season matchups, including a 12-point comeback over the final six minutes on the road, in 2011 to set up his second.

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Saints (3-4)

Next meeting: Sept. 30 in East Rutherford

Manning threw for 350 yards and six touchdowns with no interceptions and still lost (52-49) when these teams met in 2015. He gained revenge in 2016 in a low-scoring 16-13 game, by driving the Giants into position to win on a walk-off field goal.

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Andy Mills | NJ Advance Media for NJ.com

Eagles (10-18)

Next meeting: Oct. 11 in East Rutherford

Manning has thrown for more yards (7,213) and more touchdowns (51) against the Eagles than he has against any other opponent, but the Eagles mostly have had his number, including 54 sacks. In 2006, the Giants rallied from a 17-point fourth-quarter deficit to force overtime, which ended with a Manning 31-yard touchdown pass to Plaxico Burress on a third-and-11.

Manning is 0-2 against the Eagles in the playoffs, including a loss as the No. 1 seed in the 2008 season.

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Packers (2-4)

Next meeting: 2019

Manning's two regular-season wins against the Packers were in 2012 and 2013, both at MetLife Stadium. The teams also have met at Lambeau Field three times in the playoffs during Manning's career, with the visiting quarterback pulling the upset over Brett Favre once and Aaron Rodgers once.

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Jaguars (1-2)

Next meeting: Sept. 9 in East Rutherford

Manning is 0-2 all-time in Jacksonville and needed an eight-point fourth-quarter comeback for his one win against the Jaguars. The Giants and Jaguars open the 2018 season head-to-head, with former Giants coach and No. 1 Eli Manning supporter Tom Coughlin as the architect of the Jaguars roster.

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Patriots (1-2)

Next: 2019

This is misleading because it doesn't count Manning's two Super Bowl wins — both on fourth-quarter comebacks — against the Patriots. But his one regular-season win went the same way, with a last-minute fourth-quarter touchdown pass to Jake Ballard sealing a 2011 win in Foxboro. Manning also went toe-to-toe with the Patriots in a loss to end the 2007 regular season, as the Patriots finished 16-0.

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Titans (1-2)

Next meeting: Dec. 16 in East Rutherford

Manning started 0-2 against the Titans — the Giants squandered a 21-point fourth-quarter lead to Vince Young in 2006 — before coasting to a 36-7 win in Nashville in 2014. Manning's two career touchdown passes against the Titans are his fewest against any opponent.

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Chris Faytok | The Star-Ledger

Vikings (2-6)

Next meeting: 2019

The Vikings are responsible for causing fits for Manning, who has five touchdowns and 15 interceptions combined in his nine starts. Manning has three different games with at least three interceptions, including one with five, and his career quarterback rating against the Vikings (56.1) is far and away his worst against any opponent. He won games in 2010 and 2013.

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Seahawks (2-6)

Next meeting: TBD

Seattle universally is considered the toughest environment in the NFL, so it is not a surprise Manning is 1-3 playing there. He also is 1-3 at home. It's a bit surprising given he has more touchdowns (15) than interceptions (13) against the Seahawks. One of his biggest career blowouts was a 44-6 rout of the Seahawks in 2008.

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Steelers (1-3)

Next meeting: 2020

It is surprising these teams haven't yet met in a Super Bowl during the 14-year era of Manning and fellow 2004 first-round pick Ben Roethlisberger. They have five Super Bowl appearances and four rings between them, but Manning's only head-to-head win was in Pittsburgh in 2008, when the Giants scored 12 unanswered points to win 21-14. Roethlisberger beat Manning in East Rutherford in 2012, shortly after Hurricane Sandy.

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Colts (0-3)

Next meeting: Dec. 22 or Dec. 23 in Indianapolis

Eli Manning was 0-2 when his older brother, Peyton, was with the Colts, and then didn't fare any better against Andrew Luck in 2014. In fact, the last Giants quarterback to beat the Colts was Kerry Collins on the turf in 2002. This looks like one of the most winnable games on the Giants' 2018 schedule, however.

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Would you rather have Eli Manning or this quarterback in 2018?

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Chargers (0-4)

Next meeting: 2021

If Manning ends up beating 30 of the 31 NFL teams in his career, the Giants-Chargers matchup last season — when both teams were 0-4 — is going to be the one that got away because the Giants blew two second-half leads.

Philip Rivers, who the Giants drafted No. 4 overall in 2004 and traded to the Chargers for Manning, was the starter for three of those wins against Manning.

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2018 schedule (69-64)

Manning's career record against the 13 different opponents on the 2018 schedule (counting division rivals Washington, Dallas and Philadelphia only once each) is 69-64. He will face on team he is undefeated against (Texans) and one team he is winless against (Colts).

Manning has a losing record against six of the 13 opponents, including four of the first six (Jaguars, Cowboys, Saints and Eagles).

Just more proof that, any way you slice it, the first half of the Giants' schedule will be more difficult than the second.

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John Munson NJ Advance Media for NJ.com

WATCH: Eli Manning, Odell Beckham take extra snaps after practice

Ryan Dunleavy can be reached at rdunleavy@njadvancemedia.com. Follow him on Twitter @rydunleavy.