1. Minoxidil for generating new hair follicles and treating baldness

Source

The method comprises disrupting an epidermis of the scalp

and contacting it with minoxidil

2.

Shh signaling pathway stimulating agents for treating hair loss (FGF9 !! )

Source

A composition for use in treating hair loss in a subject

an agent that stimulates one or more members of the SHH signaling pathway to the subject

The invention relates to pharmaceutical compositions and methods for treating hair loss and regenerating hair follicles . Specifically, the invention relates to fibroblast growth factor-9 polypeptides and administering a fibroblast growth factor-9 polypeptide for treating hair loss or regenerating hair follicles .

. Specifically, the invention relates to fibroblast growth factor-9 polypeptides and . [0028]

The present invention provides methods of treating hair loss, treating, inhibiting, or suppressing a degenerative skin disorder, and treating androgenetic alopecia (Androgenetic Alopecia) in a subject and generating new hair follicles (HF) and increasing the size of existing HF, comprising epidermal disruption or administration of wnt, and administration of a fibroblast growth factor-9 polypeptide or another compound that upregulates sonic hedgehog gene signaling .



FGF9

[0059]

In one embodiment, the methods of the present invention comprise the step of administering a composition comprising a fibroblast growth factor-9 polypeptide, alone or in composition with one or more additional compounds. In one embodiment, FGF9 refers to Fgf-9, FGF-9, Fibroblast growth factor 9, GAF, glia activating factor, Glia-activating factor precursor, or HBGF-9. In one embodiment, the FGF9 protein of the methods of the present invention has the sequence:

In one embodiment, the methods of the present invention comprise the step of administering a composition comprising a fibroblast growth factor-9 polypeptide, alone or in composition with one or more additional compounds. In one embodiment, FGF9 refers to Fgf-9, FGF-9, Fibroblast growth factor 9, GAF, glia activating factor, Glia-activating factor precursor, or HBGF-9. In one embodiment, the FGF9 protein of the methods of the present invention has the sequence: administration of recombinant human FGF9 increased levels of sonic hedgehog (SHH) gene expression

3.

Methods and compositions for inhibiting or reducing hair loss (PGD2 !)

Source



EXAMPLE 7: HAIRED SCALP CONTAINS A POPULATION OF CD200 HIGH ALPHA-6 INTEGRIN HIGH CELLS THAT ARE LACKING IN BALD SCALP

[0500]

Haired and bald scalp samples from 5 Androgenetic Alopecia patients were subjected to staining and FACS for alpha-6 integrin and CD200. In each case, haired and bald samples from the same patient were compared. A population of alpha-6 integrinhigh CD200high cells was found to be present in the haired but not bald samples (Figure 9). These findings demonstrate the existence of a stem cell population that can be transplanted to generate new HF and treat baldness. Further, these findings demonstrate that administration of CD200 and analogues thereof can be used to treat baldness.

4. Topical Aza-dC treatment on wound healing enhanced hair follicle regeneration.

Early Topical Treatment of DNA Methyl Transferase Inhibitor, Aza-Deoxycytidine (Aza-dC), to the Healing Wound Enhanced Regeneration After Healing