A West Australian lotto player has made history by taking out the entire $50 million division 1 prize in Thursday night's Powerball jackpot.

A ticket purchased in WA was the only one to match all the correct numbers from the draw.

Lotterywest said it was the largest Lotto prize ever won in the state.

The lottery operator said the record-breaking win beat WA's previous biggest prize of $30 million, a dividend taken out four times, most recently in May.

"I'm sure this news will create great excitement and anticipation among local Lotto players and certainly among those who purchased a ticket in tonight's jackpot," Lotterywest chief executive Paul Andrew said.

The winning numbers were 3, 9, 21, 25, 27, 32 and the Powerball 18.

Lotterywest said it encouraged all players who purchased a ticket in the draw to check their numbers.

The winning ticket holder is the 50th division 1 Lotto winner this year.

The division 2 prize was shared among 14 other tickets, with two players in WA set to claim close to $75,000.

In 2013, a group of friends who bought a ticket on Queensland's Gold Coast scooped the entire $70 million first prize pool in Oz Lotto.