Benefits of using this medication

Diphenhydramine belongs to a group of medications known as antihistamines. Antihistamines are used to treat symptoms caused by allergies, including itchy and watery eyes, sneezing, runny nose, and skin irritation. Diphenhydramine also causes drowsiness, and can be used by adults and children 12 years of age and older who occasionally have trouble sleeping (insomnia). The effects of diphenhydramine can last for up to 6 hours.

If you have trouble sleeping, don’t take this medication for more than a few nights in a row. Talk to your physician about other treatment options suitable for you if you have chronic (long-term) insomnia that persists for more than a few nights at a time.

Your physician may have suggested this medication for conditions other than those listed in this article. If you have not discussed this with your physician or aren’t sure why you are taking this medication, speak to your physician. Do not stop taking this medication without consulting your physician.

dosage forms of medication

This medication is available as a 25 mg capsule and a 50 mg/30 mL liquid preparation.

dose of medication

The regular dose for adults and children 12 years of age and older to help with sleep is 25 mg to 50 mg taken by mouth at bedtime. Some people may only need to take 25 mg at bedtime if they are drowsy in the morning (e.g., they find it interferes with their daily activities) after taking the 50 mg dose.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your physician has recommended a dose different from the ones listed here, don’t change the way that you are taking the medication without consulting your physician.

It is important to take this medication exactly as prescribed by your physician.

Store this medication at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Contraindications to the use of the medication

Do not take this medication if you:

are allergic to diphenhydramine or any ingredients of the medication

have an enlarged prostate

have an obstructed bladder

have asthma or chronic lung disease

have certain stomach conditions (e.g., stenosing peptic ulcer or pyloroduodenal obstruction)

have narrow-angle glaucoma

have taken an antidepressant medication known as a MAO inhibitor (e.g., phenelzine, tranylcypromine, linezolid) within the past 2 weeks

side effects of the medication

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below aren’t experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your physician.

These symptoms may occur in some patients and in this case, you should refer to your consultant. But the majority of the patients don’t suffer from any side effects, so do not stop using the medicine because of fear of in listed side effect . , .

Contact your physician if you experience these side effects and intolerable. Your pharmacist may be able to advise you on managing side effects.

chest congestion

constipation

dizziness

drowsiness

dry mouth, nose, and throat

headache

inability to concentrate

increased perspiration

nausea or vomiting

restlessness

upset stomach

Although most of the side effects listed below don’t happen very often, they could lead to serious problems if you don’t seek medical attention.

Check with your physician as soon as possible if any of the following side effects occur:

decreased muscle coordination

difficulty in passing urine

excitation (especially in children)

insomnia

muscle weakness

nervousness

rapid heart rate

vision problems

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest tightness

skin rash or hives

wheezing

Some people may experience side effects other than those listed. Check with your physician if you notice any symptom that worries you while you are taking this medication.

precautions of the medication

Before you start using a medication, be sure to inform your physician of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Bladder or urinary problems: Diphenhydramine can worsen symptoms of bladder problems. If you have a history of bladder problems, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Drowsiness/reduced alertness: Avoid driving or operating machinery until you have determined that you don’t become drowsy during the day or experience impaired mental or physical abilities while taking this medication. Alcohol, sedatives, and pain medications can increase the side effects (e.g., drowsiness, inability to concentrate) of this medication. Do not undertake any activities that require alertness until you know how this medication affects you.

High blood pressure: If you have high blood pressure, discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Lung problems: This medication can make breathing problems worse. If you have lung problems such as asthma or chronic obstructive pulmonary disease (COPD), discuss with your physician how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Medical conditions: For some people, insomnia is caused by other medical conditions. If you have trouble sleeping for longer than 2 weeks, contact your physician before taking this medication.

Thyroid disease: People with thyroid disease should discuss with their physician how this medication may affect their medical condition, how their medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Pregnancy: This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your physician immediately.

Breast-feeding: This medication may pass into breast milk. If you are a breast-feeding mother and are taking diphenhydramine, it may affect your baby. Talk to your physician about whether you should continue breast-feeding.

Children: Diphenhydramine isn’t recommended for use as a sleep aid for children less than 12 years of age.

Seniors: Seniors may experience more side effects with this medication. Talk to your physician before taking this medication.

Drug-Drug interaction of the medication

There may be an interaction between diphenhydramine and any of the following:

aclidinium

alcohol

alfuzosin

amiodarone

amphetamines (e.g., dextroamphetamine, lisdexamphetamine)

antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)

atomoxetine

atropine

azelastine

barbiturates (e.g., butalbital, pentobarbital, phenobarbital)

belladonna

benzodiazepines (e.g., alprazolam, diazepam, lorazepam)

benztropine

botulinum toxins

brimonidine

buprenorphine

buspirone

captopril

carvedilol

chloral hydrate

chloroquine

cyclobenzaprine

degarelix

dextromethorphan

disopyramide

dofetilide

domperidone

donepezil

doxorubicin

dronabinol

dronedarone

efavirenz

flavoxate

flecainide

galantamine

general anesthetics (medications used to put people to sleep before surgery)

glycopyrrolate

hyaluronidase

ipratropium

ketotifen

lopinavir

macrolide antibiotics (e.g., clarithromycin, erythromycin)

magnesium sulfate

methadone

methamphetamine

metoprolol

mexiletine

mifepristone

minocycline

mirabegron

mirtazapine

muscle relaxants (e.g., baclofen, cyclobenzaprine, methocarbamol, orphenadrine)

nabilone

narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone)

nefazodone

olopatadine

other antihistamines (e.g,. cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)

oxybutynin

perampanel

pimozide

potassium chloride

pramipexole

procainamide

quinidine

quinine

quinolone antibiotics (e.g., ciprofloxacin, ofloxacin, sparfloxacin)

rilpivirine

rivastigmine

ropinirole

rotigotine

rufinamide

scopolamine

secretin

seizure medications (e.g., clobazam, ethosuximide, felbamate, levetiracetam, phenobarbital, phenytoin, primidone, topiramate, valproic acid, zonisamide)

selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, duloxetine, fluoxetine, paroxetine, sertraline)

serotonin agonists (e.g., dolasetron, granisetron, ondansetron)

sotalol

tamoxifen

tapentadol

thalidomide

timolol

tiotropium

tolterodine

topiramate

tramadol

tranylcypromine

trazodone

tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline)

tyrosine kinase inhbitors (e.g., lapatinib, pazopanib, sunitinib)

umeclidinium

venlafaxine

voriconazole

zolpidem

zopiclone

If you are taking any of these medications, talk to your physician or pharmacist. Depending on your specific circumstances, your physician may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications doesn’t always mean that you must stop taking one of them. talk to your physician about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your physician or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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