Nurse Jackie will remain on duty for a seventh season, but the cast will look a little different. Showtime has handed out an early seventh season renewal to the Edie Falco series, but Peter Facinelli will not return to the cable series as a regular. E! News has confirmed he will appear in some capacity.

Season six of Nurse Jackie is set to premiere on Sunday, April 13, at 9 p.m.

"In the twilight of season six, Peter asked to be released from his contract to pursue new creative challenges. Nothing will eclipse the incredible contribution he made to the success of Nurse Jackie since the dawn of the show," showrunner Clyde Phillips said in a statement, referencing Facinelli's Twilight film series work.