A woman has been charged over the alleged stabbing of a man in a domestic violence incident in Sydney's western suburbs this morning.

Emergency services were first called to a home on Saddington Street in St Marys about 12.50am following reports of a domestic incident.

Police who arrived at the home found a 29-year-old man with a stab wound to his shoulder.

A man has been taken to hospital and a woman charged by police in an alleged domestic violence incident. (9news)

He was taken to Nepean Hospital, where he remains today in a stable condition with non-life-threatening injuries.

The female offender had allegedly fled the scene before police arrived.

A crime scene was established at the home and detectives from the Nepean Police Area Command started an investigation into the incident.

The 29-year-old man was found with a stab wound to his shoulder by police who attended the St Mary's home, in Sydney's west. (9news)

The 20-year-old woman allegedly fled the scene and was later arrested by police. (9news)

Police later found a 20-year-old woman about 2am at another home on Mamre Road.

She has since been taken to Penrith Police Station, where she was this morning charged with wounding a person with intent to cause grievous bodily harm.

The woman was also refused bail and will appear at Parramatta Bail Court later today.