There's something in the air at Denver Broncos headquarters -- and it ain't love.

Multiple Broncos players, including quarterback Trevor Siemian, linebacker Shane Ray and defensive end Shelby Harris, are dealing with a "flu bug" that's spreading throughout the team facility, coach Vance Joseph revealed Wednesday.

"Hopefully guys take care of themselves and we can get a handle on that," said Joseph. "It’s about four or five guys that are sick right now, especially in the D-line room.”

Among the aforementioned, Harris seems to have been affected the worst. He did not practice as the team began preparations for Sunday's road contest against the Dolphins. Siemian got in a full session while Ray was listed as limited on the first Week 13 injury report.

“A couple of us got it," said Siemian. "We’ll be alright.”

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Denver's defensive line is racked with maladies at the moment; nose tackle Domata Peko (knee) is iffy to play and DE Derek Wolfe (neck) is unlikely to suit up.

The Broncos are keeping especially close tabs on Wolfe, who's visiting with multiple doctors after spraining his neck in last week's loss to the Raiders. There's a chance he's shut down for the rest of the year.

“He is being evaluated," said Joseph. "When you’re talking about a neck and a head injury, you want to be smart with those guys. His overall health is more important than our next five games. We want to make sure he’s ready to play before we get him back on the field. It’s a neck injury, so that can be scary without knowing everything about it.”

Right guard Ronald Leary (back), quarterback Paxton Lynch (ankle), wide receiver Emmanuel Sanders (ankle) also did not practice. Inside linebacker Todd Davis (ankle/shoulder), DE Adam Gotsis (ankle/shoulder) and tight end Jeff Heuerman (knee) were limited.

Defensive lineman Zach Kerr, who has a toe injury, was a full participant.

The Broncos will release an updated injury report on Thursday.

For more Broncos news, follow Zack Kelberman on Twitter: @Kelberman247