Indiana health officials on Friday reported the state's first vaping-related death, marking the third such death nationwide.

“The tragic loss of a Hoosier and rising number of vaping-related injuries are warnings that we cannot ignore,” Indiana Health Commissioner Kris Box said in a statement Friday.

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“We know that these products typically contain nicotine, which is highly addictive, and many cases report inhaling THC and other substances not available in commercial products," she added. "While it is unclear what substances are causing injury, when you use these products with other chemicals, you may not know everything that you’re inhaling and the harm it can cause.”

Nationwide, the Centers for Disease Control and Prevention is investigating 450 possible cases of lung illness associated with vaping.