This story appears in the May 2017 issue of National Geographic magazine.



The Mütter Museum in Philadelphia houses an array of singular medical specimens. On the lower level the fused livers of 19th-century conjoined twins Chang and Eng float in a glass vessel. Nearby, visitors can gawk at hands swollen with gout, the bladder stones of Chief Justice John Marshall, the cancerous tumor extracted from President Grover Cleveland’s jaw, and a thighbone from a Civil War soldier with the wounding bullet still in place. But there’s one exhibit near the entrance that elicits unmatchable awe. Look closely at the display, and you can see smudge marks left by museumgoers pressing their foreheads against the glass.

The object that fascinates them is a small wooden box containing 46 microscope slides, each displaying a slice of Albert Einstein’s brain. A magnifying glass positioned over one of the slides reveals a piece of tissue about the size of a stamp, its graceful branches and curves resembling an aerial view of an estuary. These remnants of brain tissue are mesmerizing even though—or perhaps because—they reveal little about the physicist’s vaunted powers of cognition. Other displays in the museum show disease and disfigurement—the results of something gone wrong. Einstein’s brain represents potential, the ability of one exceptional mind, one genius, to catapult ahead of everyone else. “He saw differently from the rest of us,” says visitor Karen O’Hair as she peers at the tea-colored sample. “And he could extend beyond that to what he couldn’t see, which is absolutely amazing.”

Throughout history rare individuals have stood out for their meteoric contributions to a field. Lady Murasaki for her literary inventiveness. Michelangelo for his masterful touch. Marie Curie for her scientific acuity. “The genius,” wrote German philosopher Arthur Schopenhauer, “lights on his age like a comet into the paths of the planets.” Consider Einstein’s impact on physics. With no tools at his disposal other than the force of his own thoughts, he predicted in his general theory of relativity that massive accelerating objects—like black holes orbiting each other—would create ripples in the fabric of space-time. It took one hundred years, enormous computational power, and massively sophisticated technology to definitively prove him right, with the physical detection of such gravitational waves less than two years ago.

Einstein revolutionized our understanding of the very laws of the universe. But our understanding of how a mind like his works remains stubbornly earthbound. What set his brainpower, his thought processes, apart from those of his merely brilliant peers? What makes a genius?

View Images A century after Einstein predicted the existence of gravitational waves—ripples in the fabric of space-time— in his general theory of relativity, scientists like Kazuhiro Yamamoto (on bicycle) plan to use the first underground gravitational wave telescope, KAGRA, in Hida, Japan, to explore what he deduced but could not detect.

Philosophers have long been pondering the origins of genius. Early Greek thinkers believed an overabundance of black bile—one of the four bodily humors proposed by Hippocrates—endowed poets, philosophers, and other eminent souls with “exalted powers,” says historian Darrin McMahon, author of Divine Fury: A History of Genius. Phrenologists attempted to find genius in bumps on the head; craniometrists collected skulls—including philosopher Immanuel Kant’s—which they probed, measured, and weighed.

None of them discovered a single source of genius, and such a thing is unlikely to be found. Genius is too elusive, too subjective, too wedded to the verdict of history to be easily identified. And it requires the ultimate expression of too many traits to be simplified into the highest point on one human scale. Instead we can try to understand it by unraveling the complex and tangled qualities—intelligence, creativity, perseverance, and simple good fortune, to name a few—that entwine to create a person capable of changing the world.

Intelligence has often been considered the default yardstick of genius—a measurable quality generating tremendous accomplishment. Lewis Terman, the Stanford University psychologist who helped pioneer the IQ test, believed a test that captured intelligence would also reveal genius. In the 1920s he began tracking more than 1,500 Californian schoolkids with IQs generally above 140—a threshold he labeled as “near genius or genius”—to see how they fared in life and how they compared with other children. Terman and his collaborators followed the participants, nicknamed “Termites,” for their lifetimes and mapped their successes in a series of reports, Genetic Studies of Genius. The group included members of the National Academy of Sciences, politicians, doctors, professors, and musicians. Forty years after the study began, the researchers documented the thousands of academic reports and books they published, as well as the number of patents granted (350) and short stories written (about 400).

But monumental intelligence on its own is no guarantee of monumental achievement, as Terman and his collaborators would discover. A number of the study’s participants struggled to thrive, despite their towering IQ scores. Several dozen flunked out of college at first. Others, tested for the study but with IQs that weren’t high enough to make the cut, grew up to become renowned in their fields, most famously Luis Alvarez and William Shockley, both of whom won Nobel Prizes in physics. There’s precedent for such underestimation: Charles Darwin recalled being considered “a very ordinary boy, rather below the common standard in intellect.” As an adult he solved the mystery of how the splendid diversity of life came into being.

View Images Unexpected flashes of insight still require some thought. After seeing an apple fall perpendicularly to the ground in 1666, Isaac Newton reasoned that, in a friend’s telling, “there must be a drawing power in matter.” The tree that sparked his law of gravity remains rooted next to his childhood home at Woolsthorpe Manor, England.

Scientific breakthroughs like Darwin’s theory of evolution by natural selection would be impossible without creativity, a strand of genius that Terman couldn’t measure. But creativity and its processes can be explained, to a certain extent, by creative people themselves. Scott Barry Kaufman, scientific director of the Imagination Institute in Philadelphia, has been bringing together individuals who stand out as trailblazers in their fields—people like psychologist Steven Pinker and comedian Anne Libera of the Second City—to talk about how their ideas and insights are kindled. Kaufman’s goal is not to elucidate genius—he considers the word to be a societal judgment that elevates a chosen few while overlooking others—but to nurture imagination in everyone.

These discussions have revealed that the aha moment, the flash of clarity that arises at unexpected times—in a dream, in the shower, on a walk—often emerges after a period of contemplation. Information comes in consciously, but the problem is processed unconsciously, the resulting solution leaping out when the mind least expects it. “Great ideas don’t tend to come when you’re narrowly focusing on them,” says Kaufman.

Studies of the brain offer hints at how these aha moments might happen. The creative process, says Rex Jung, a neuroscientist at the University of New Mexico, relies on the dynamic interplay of neural networks operating in concert and drawing from different parts of the brain at once—both the right and left hemispheres and especially regions in the prefrontal cortex. One of these networks fosters our ability to meet external demands—activities we must act on, like going to work and paying our taxes—and resides largely in outer areas of the brain. The other cultivates internal thought processes, including daydreaming and imagining, and stretches mainly across the brain’s middle region.

View Images Prodigious productivity is a defining characteristic of genius. Charcoal sketches cover the walls of a once concealed room beneath the Medici Chapel in Florence, where Michelangelo hid for three months in 1530 after defying his patrons. The drawings include a sketch of a seated figure (right) who appears on a tomb in the chapel above.

Jazz improvisation provides a compelling example of how neural networks interact during the creative process. Charles Limb, a hearing specialist and auditory surgeon at UC San Francisco, designed an iron-free keyboard small enough to be played inside the confines of an MRI scanner. Six jazz pianists were asked to play a scale and a piece of memorized music and then to improvise solos as they listened to the sounds of a jazz quartet. Their scans demonstrate that brain activity was “fundamentally different” while the musicians were improvising, says Limb. The internal network, associated with self-expression, showed increased activity, while the outer network, linked to focused attention and also self-censoring, quieted down. “It’s almost as if the brain turned off its own ability to criticize itself,” he says.

This may help explain the astounding performances of jazz pianist Keith Jarrett. Jarrett, who improvises concerts that last for as long as two hours, finds it difficult—impossible, actually—to explain how his music takes shape. But when he sits down in front of audiences, he purposefully pushes notes out of his mind, moving his hands to keys he had no intention of playing. “I’m bypassing the brain completely,” he tells me. “I am being pulled by a force that I can only be thankful for.” Jarrett specifically remembers one concert in Munich, where he felt as if he had disappeared into the high notes of the keyboard. His creative artistry, nurtured by decades of listening, learning, and practicing melodies, emerges when he is least in control. “It’s a vast space in which I trust there will be music,” he says.

One sign of creativity is being able to make connections between seemingly disparate concepts. Richer communication between areas of the brain may help make those intuitive leaps possible. Andrew Newberg, director of research at the Marcus Institute of Integrative Health at Thomas Jefferson University Hospitals, is using diffusion tensor imaging, an MRI contrast technique, to map neural pathways in the brains of creative people. His participants, who come from Kaufman’s pool of big thinkers, are given standard creativity tests, which ask them to come up with novel uses for everyday objects like baseball bats and toothbrushes. Newberg aims to compare the connectivity in the brains of these high achievers against that of a group of controls to see if there is a difference in how effectively the various regions of their brains interact. His ultimate goal is to scan as many as 25 in each category and then pool the data so he can look for similarities within each group as well as differences that may appear across vocations. For instance, are certain areas more active in a comedian’s brain compared with a psychologist’s?

View Images Some 10,000 pairs of identical and fraternal twins are part of geneticist Robert Plomin’s longitudinal study at King’s College London, providing clues about how genes and environment affect development. The genetics of intelligence are enormously complex. “Most geniuses,” says Plomin, “don’t come from genius parents.”

A preliminary comparison of one “genius”—Newberg uses the word loosely to distinguish the two groups of participants—and one control reveals an intriguing contrast. On the subjects’ brain scans, swaths of red, green, and blue illuminate tracts of white matter, which contain the wiring that allows neurons to transmit electrical messages. The red blotch on each image is the corpus callosum, a centrally located bundle of more than 200 million nerve fibers that joins the two hemispheres of the brain and facilitates connectivity between them. “The more red you see,” Newberg says, “the more connecting fibers there are.” The difference is notable: The red section of the “genius” brain appears to be about twice as wide as the red of the control brain.

“This implies that there’s more communication going on between the left and the right hemispheres, which one might expect in people who are highly creative,” says Newberg, stressing that this is an ongoing study. “There’s more flexibility in their thought processes, more contributions from different parts of the brain.” The green and blue swaths show other areas of connectivity, stretching from front to back—including dialogue among the frontal, parietal, and temporal lobes—and may reveal additional clues, says Newberg. “I don’t know yet what else we might find out. This is just one piece.”

Even as neuroscientists try to understand how the brain fosters the development of paradigm-shifting thought processes, other researchers are wrestling with the question of when and from what this capacity develops. Are geniuses born or made? Francis Galton, a cousin of Darwin, objected to what he called “pretensions of natural equality,” believing that genius was passed down through family bloodlines. To prove it, he mapped the lineages of an array of European leaders in disparate fields—from Mozart and Haydn to Byron, Chaucer, Titus, and Napoleon. In 1869 Galton published his results in Hereditary Genius, a book that would launch the “nature versus nurture” debate and spur the misbegotten field of eugenics. Geniuses were rare, Galton concluded, numbering roughly one in a million. What was not unusual, he wrote, were the many instances “in which men who are more or less illustrious have eminent kinsfolk.”

View Images Stephen Wiltshire, a British artist with autism, created an exquisitely accurate panorama of Mexico City after one afternoon’s viewing and five days of drawing. Psychiatrist Darold Treffert believes that unique wiring between the brain’s right and left hemispheres allows people like Wiltshire to access reserves of creativity. Watch Wiltshire draw an entire city from memory.

Advances in genetic research now make it possible to examine human traits at the molecular level. Over the past several decades, scientists have been searching for genes that contribute to intelligence, behavior, and even unique qualities like perfect pitch. In the case of intelligence, this research triggers ethical concerns about how it might be used; it is also exceedingly complex, as thousands of genes may be involved—each one with a very small effect. What about other kinds of abilities? Is there something innate in having an ear for music? Numerous accomplished musicians, including Mozart and Ella Fitzgerald, are believed to have had perfect pitch, which may have played a role in their extraordinary careers.

Genetic potential alone does not predict actual accomplishment. It also takes nurture to grow a genius. Social and cultural influences can provide that nourishment, creating clusters of genius at moments and places in history: Baghdad during Islam’s Golden Age, Kolkata during the Bengal Renaissance, Silicon Valley today.

A hungry mind can also find the intellectual stimulation it needs at home—as in suburban Adelaide, Australia, in the case of Terence Tao, widely considered one of the greatest minds currently working in mathematics. Tao showed a remarkable grasp of language and numbers early in life, but his parents created the environment in which he could flourish. They provided him with books, toys, and games and encouraged him to play and learn on his own—a practice his father, Billy, believes stimulated his son’s originality and problem-solving skills. Billy and his wife, Grace, also sought out advanced learning opportunities for their son as he began his formal education, and he was fortunate to meet educators who helped foster and stretch his mind. Tao enrolled in high school classes when he was seven years old, scored 760 on the math section of the SAT at age eight, went to university full-time when he was 13, and became a professor at UCLA at 21. “Talent is important,” he once wrote on his blog, “but how one develops and nurtures it is even more so.”

Age and Achievement Are you over the hill? Depends on what you’re trying to achieve. In 1953 psychologist Harvey Lehman published what remains the most comprehensive study of age and achievement. Using the most cited works at the time—and the age of each work’s creator—he illustrated when outstanding achievement is most likely by discipline. There are exceptions: Giuseppe Verdi composed Aida at 58, two decades older than grand opera’s peak age range. Lehman offered 16 factors for why achievement occurs when it does, including declining health and motivation as we age. Psychologist Dean Keith Simonton, an expert on genius, maintains that the arc of a career depends on two things: your chosen discipline, and how soon you master it. Poets tend to turn ideas into finished works faster than novelists; within a field, geniuses are the quickest studies. “Individual differences are actually so large that they swamp the impact of age,” wrote Simonton. “A first-rate genius at 80 is worth more than a second-rate talent at half that age.” Years with highest probability for producing a work of genius Discipline Number of works by number of individuals Name Work 100% AGE 20 30 40 50 60 A LIFE’S WORK Lehman divided the number of works produced in each discipline during each five-year interval by the number of creators who were alive in that span. He charted those rates as percentages of peak output. Marie Curie Discovered radium Chemistry works by 46 chemists AGE 20 30 40 50 60 70 80 Srinivasa Ramanujan Highly composite numbers Mathematics Albert Einstein Theories of relativity Isaac Newton Principia Physics Thomas Edison Phonograph SCIENCE Inventions 30-34 Sigmund Freud Psychoanalysis Psychology AGE 20 30 40 50 60 70 80 Johannes Kepler Astronomia Nova Astronomy 40-44 J. S. Bach Cello suites Instrumental Music 10 20 25-29 Ludwig van Beethoven Symphony No. 5 Symphonies MUSIC 30-34 Grand Operas Giuseppe Verdi Aida 35-39 Rembrandt Etching “The Three Trees” AGE 20 30 40 50 60 70 80 Michelangelo Sculpture “David” ART Michelangelo Sistine Chapel ceiling Painting 35-39 William Wordsworth Poetry “Tintern Abbey” Elizabeth Bishop “Sestina” 25-29 William Shakespeare Hamlet Theater LITERATURE Virginia Woolf Mrs Dalloway Novels AGE 20 30 40 50 60 70 80 Age and Achievement Marie Curie Discovered radium Chemistry works by 46 chemists Are you over the hill? Depends on what you’re trying to achieve. In 1953 psychologist Harvey Lehman published what remains the most comprehensive study of age and achievement. Using the most cited works at the time—and the age of each work’s creator—he illustrated when outstanding achievement is most likely by discipline. There are exceptions: Giuseppe Verdi composed Aida at 58, two decades older than grand opera’s peak age range. Lehman offered 16 factors for why achievement occurs when it does, including declining health and motivation as we age. Psychologist Dean Keith Simonton, an expert on genius, maintains that the arc of a career depends on two things: your chosen discipline, and how soon you master it. Poets tend to turn ideas into finished works faster than novelists; within a field, geniuses are the quickest studies. “Individual differences are actually so large that they swamp the impact of age,” wrote Simonton. “A first-rate genius at 80 is worth more than a second-rate talent at half that age.” AGE 20 30 40 50 60 70 80 Srinivasa Ramanujan Highly composite numbers Mathematics Albert Einstein Theories of relativity Isaac Newton Principia Physics SCIENCE Thomas Edison Phonograph Inventions 30-34 Sigmund Freud Psychoanalysis Psychology AGE 20 30 40 50 60 70 80 Johannes Kepler Astronomia Nova Astronomy 40-44 J. S. Bach Cello suites Instrumental Music 10 20 25-29 Ludwig van Beethoven Symphony No. 5 Symphonies MUSIC 30-34 Giuseppe Verdi Aida Grand Operas 35-39 Rembrandt Etching “The Three Trees” AGE 20 30 40 50 60 70 80 Michelangelo Years with highest probability for producing a work of genius Sculpture “David” ART Discipline Number of works by number of individuals Name Work Michelangelo Sistine Chapel ceiling Painting 100% 35-39 AGE 20 30 40 50 60 William Wordsworth Elizabeth Bishop Poetry “Tintern Abbey” A LIFE’S WORK Lehman divided the number of works produced in each discipline during each five-year interval by the number of creators who were alive in that span. He charted those rates as percentages of peak output. “Sestina” 25-29 William Shakespeare Hamlet Theater LITERATURE Virginia Woolf Mrs Dalloway Novels AGE 20 30 40 50 60 70 80 Oliver Uberti. CONSULTANT: DEAN KEITH SIMONTON, PROFESSOR EMERITUS, University of California, DAVIS

Source: age and Achievement, by Harvey C. Lehman

Social Networks of Genius Lone geniuses are exceedingly rare. Dean Keith Simonton scoured biographical dictionaries for mentions of relationships among 2,026 scientists and 772 artists. He found that members of each field created within a web of connections, as shown below for Isaac Newton and Michelangelo. 14 idols, including Bacon Copernicus Descartes Galileo Kepler 3 rivals Hooke Huygens Leibniz 1 mentor Barrow 1 collaborator Halley 10 associates Flamsteed Newton 1 friend Locke 12 admirers Einstein Euler Goethe According to the poet William Words­worth, Isaac Newton was “a mind for ever Voyaging through strange seas of Thought, alone.” But Newton knew the leading scientists in Europe. He read their work, and they read his. In a letter Newton wrote, “If I have seen further it is by standing on the shoulders of Giants.” 8 idols Donatello Ghiberti Giotto Masaccio 2 rivals Leonardo Signorelli 2 mentors Bertoldo Ghirlandaio 1 collaborator Sebastiano Michelangelo 2 apprentices Cellini Condivi 1 friend Vasari 1 co-pupil Torrigiano 40 admirers Rubens Titian Velázquez With help from his father, Michelangelo landed an apprenticeship with Domenico Ghirlandaio, a Florentine painter. The teacher soon sent his gifted student to work in Lorenzo de’ Medici’s sculpture garden. That break immersed Michelangelo in some of the world’s greatest art—and its deepest pockets. Social Networks of Genius Lone geniuses are exceedingly rare. Dean Keith Simonton scoured biographical dictionaries for mentions of relationships among 2,026 scientists and 772 artists. He found that members of each field created within a web of connections, as shown below for Isaac Newton and Michelangelo. 8 idols Donatello Ghiberti Giotto Masaccio 14 idols, including Bacon Copernicus Descartes Galileo Kepler 2 rivals Leonardo Signorelli 3 rivals Hooke Huygens Leibniz 2 mentors Bertoldo Ghirlandaio 1 collaborator Sebastiano 1 collaborator Halley 1 mentor Barrow 10 associates Flamsteed Michelangelo Newton 2 apprentices Cellini Condivi 1 friend Vasari 1 friend Locke 40 admirers Rubens Titian Velázquez 1 co-pupil Torrigiano 12 admirers Einstein Euler Goethe According to the poet William Words­worth, Isaac Newton was “a mind for ever Voyaging through strange seas of Thought, alone.” But Newton knew the leading scientists in Europe. He read their work, and they read his. In a letter Newton wrote, “If I have seen further it is by standing on the shoulders of Giants.” With help from his father, Michelangelo landed an apprenticeship with Domenico Ghirlandaio, a Florentine painter. The teacher soon sent his gifted student to work in Lorenzo de’ Medici’s sculpture garden. That break immersed Michelangelo in some of the world’s greatest art—and its deepest pockets. Oliver Uberti. Source: DEAN KEITH SIMONTON, PROFESSOR EMERITUS, University of California, DAVIS

Portrait Photos: Paul D. Stewart, Science Source (Newton); Scala/Art Resource, NY (Michelangelo)

Natural gifts and a nurturing environment can still fall short of producing a genius, without motivation and tenacity propelling one forward. These personality traits, which pushed Darwin to spend two decades perfecting Origin of Species and Indian mathematician Srinivasa Ramanujan to produce thousands of formulas, inspire the work of psychologist Angela Duckworth. She believes that a combination of passion and perseverance—what she calls “grit”—drives people to achieve. Duckworth, herself a MacArthur Foundation “genius” and a professor of psychology at the University of Pennsylvania, says the concept of genius is too easily cloaked in layers of magic, as if great achievement erupts spontaneously with no hard work. She believes there are differences when it comes to individual talent, but no matter how brilliant a person, fortitude and discipline are critical to success. “When you really look at somebody who accomplishes something great,” she says, “it is not effortless.”

Nor does it happen on the first try. “The number one predictor of impact is productivity,” says Dean Keith Simonton, professor emeritus of psychology at UC Davis and a longtime scholar of genius. Big hits emerge after many attempts. “Most articles published in the sciences are never cited by anybody,” says Simonton. “Most compositions are not recorded. Most works of art aren’t displayed.” Thomas Edison invented the phonograph and the first commercially viable light bulb, but these were just two of the thousand-plus U.S. patents he was awarded.

Lack of support can stunt prospects for potential geniuses; they never get the chance to be productive. Throughout history women have been denied formal education, deterred from advancing professionally, and under-recognized for their achievements. Mozart’s older sister, Maria Anna, a brilliant harpsichordist, had her career cut short by her father when she reached the marriageable age of 18. Half the women in the Terman study ended up as homemakers. People born into poverty or oppression don’t get a shot at working toward anything other than staying alive. “If you do believe that genius is this thing that can be singled out and cultivated and nurtured,” says historian Darrin McMahon, “what an incredible tragedy that thousands of geniuses or potential geniuses have withered and died.”

Lateral prefrontal deactivation Self-monitoring Medial prefrontal activation Self-expression Charles Limb (brain image) Lateral prefrontal deactivation Self-monitoring Medial prefrontal activation Self-expression Charles Limb (brain image) An fMRI brain scan illustrates brain activity during improvisation.



Sometimes, by sheer good fortune, promise and opportunity collide. If there were ever an individual who personified the concept of genius in every aspect, from its ingredients to its far-reaching impact, it would be Leonardo da Vinci. Born in 1452 to unmarried parents, Leonardo began life in a stone farmhouse in Italy’s Tuscan hills, where olive trees and dusky blue clouds blanket the Arno Valley. From these simple beginnings, Leonardo’s intellect and artistry soared like Schopenhauer’s comet. The breadth of his abilities—his artistic insights, his expertise in human anatomy, his prescient engineering—is unparalleled.

Leonardo’s pathway to genius began with an apprenticeship with master artist Andrea del Verrocchio in Florence when he was a teenager. Leonardo’s creativity was so robust that in his lifetime he filled thousands of pages in his notebooks, which brimmed with studies and designs, from the science of optics to his famed inventions, including a revolving bridge and a flying machine. He persisted no matter the challenge. “Obstacles cannot crush me,” he wrote. “He who is fixed to a star does not change his mind.” Leonardo also lived in a place (Florence) and at a time (the Italian Renaissance) when the arts were cultivated by wealthy patrons and inventiveness coursed through the streets, where great minds, including Michelangelo and Raphael, jostled for acclaim.

Leonardo delighted in envisioning the impossible—hitting a target that, as Schopenhauer wrote, “others cannot even see.” Today an international group of scholars and scientists has taken on a similar mission, and its subject is just as elusive: Leonardo himself. The Leonardo Project is tracing the artist’s genealogy and hunting down his DNA to learn more about his ancestry and physical characteristics, to verify paintings that have been attributed to him—and, most remarkably, to search for clues to his extraordinary talent.

Team member David Caramelli’s high-tech molecular anthropology lab at the University of Florence sits in a 16th-century building with a glorious view of the Florentine skyline. Jutting out majestically is the dome of the city’s prominent cathedral, Santa Maria del Fiore, whose original crowning copper-gilt ball was made by Verrocchio and raised to the top of the cupola with Leonardo’s help in 1471. This juxtaposition of past and present is a fitting setting for Caramelli’s expertise in ancient DNA. Two years ago he published preliminary genetic analyses of a Neanderthal skeleton. Now he is poised to apply similar techniques to Leonardo’s DNA, which the team is hoping to extract from some form of biological relic—the artist’s bones, a strand of hair, skin cells left behind on his paintings or notebooks, or perhaps even saliva, which Leonardo may have used to prepare canvases for his silverpoint drawings.

View Images Throughout history bright minds have flocked to nexuses of creativity like Silicon Valley, where Wenzhao Lian, a researcher at Vicarious, an artificial intelligence company, teaches a robot how to recognize and manipulate objects. The company aims to develop programs that mimic the brain’s capacity for vision, language, and motor control.

It is an ambitious plan, but team members are optimistically laying the groundwork. Genealogists are tracking down Leonardo’s living relatives on his father’s side for cheek swabs, which Caramelli will use to identify a genetic marker to confirm the authenticity of Leonardo’s DNA if it is found. Physical anthropologists are seeking access to remains that are believed to be Leonardo’s at Amboise castle in France’s Loire Valley, where he was buried in 1519. Art historians and geneticists, including specialists at the institute of genomics pioneer J. Craig Venter, are experimenting with techniques to obtain DNA from fragile Renaissance-era paintings and paper. “The wheels are starting to turn,” says Jesse Ausubel, vice chairman of the Richard Lounsbery Foundation and an environmental scientist at Rockefeller University in New York City, who is coordinating the project.

View Images Mathematician Terence Tao’s formulas on fluid dynamics are written on the blackboard behind him. Hailed for his “otherworldly ingenuity,” Tao won the prestigious Fields Medal in 2006 at the age of 31. Yet he rejects lofty notions of genius. What really matters, he writes, is “hard work, directed by intuition, literature, and a bit of luck.”

One of the group’s early goals is to explore the possibility that Leonardo’s genius stemmed not only from his intellect, creativity, and cultured environment but also from his exemplary powers of perception. “In the same way that Mozart may have had extraordinary hearing,” says Ausubel, “Leonardo appears to have had extraordinary visual acuity.” Some of the genetic components of vision are well identified, including the red and green color-vision pigment genes, located on the X chromosome. Thomas Sakmar, a specialist in sensory neuroscience at Rockefeller, says it’s conceivable that scientists could explore those regions of the genome to see if Leonardo had any unique variations that changed his color palette, allowing him to see more hues of red or green than most people are able to perceive.

The Leonardo Project team doesn’t yet know where to look for answers to other questions, such as how to explain Leonardo’s remarkable ability to visualize birds in flight. “It’s as if he was creating stroboscopic photographs of stop-action,” says Sakmar. “It’s not far-fetched that there would be genes related to that ability.” He and his colleagues view their work as the beginning of an expedition that will lead them down new pathways as DNA gives up its secrets.

The quest to unravel the origins of genius may never reach an end point. Like the universe, its mysteries will continue to challenge us, even as we reach for the stars. For some, that is as it should be. “I don’t want to figure it out at all,” says Keith Jarrett when I ask if he is comfortable not knowing how his music takes hold. “If someone offered me the answer, I’d say, Take it away.” In the end it may be that the journey is illuminating enough and that the insights it reveals along the way—about the brain, about our genes, about the way we think—will nurture glimmers of genius in not just the rare individual but in us all.