Researchers have captured and killed the largest Burmese python to be removed from Big Cypress National Preserve in the Florida Everglades, wildlife officials say.

The 5.2-metre, 64-kilogram female snake - an invasive species devastating to native wildlife - was discovered using a new tracking approach that leans on technology and the laws of attraction.

Burmese pythons caught in Florida are often 1.8 to three metres long, the Florida Fish and Wildlife Conservation Commission said. In their native lands, the snakes commonly reach 5.5 to more than six metres.

Wildlife officials say this snake is the largest Burmese python ever to be removed from Big Cypress National Preserve in the Florida Everglades. Credit:US National Park Service via The Washington Post

Male pythons are tagged with radio transmitters, allowing researchers to track the male as it moves towards breeding females. The female python that wildlife officials found last week contained 73 developing eggs. The breeding season for Burmese pythons is between January and April.