A continuing police crackdown near Melbourne's busy Chapel Street has ended with a dozen arrests for drug-related offences.

Operation Safenight, which launched in April and continues on Saturday nights until August, saw officers once again target the entertainment precinct in Prahran.

Police caught a dozen people for drug-related offences. Credit:Scott Barbour/Fairfax Media

Seven people were arrested overnight for drug offences while another five people were caught driving while on drugs for a total of a dozen drug-related arrests.

Drugs seized during the operation included cannabis and GHB with a total of 44 offences detected overnight, ranging from drug possession to drink driving and driving while disqualified.