Chris Cuomo is giving another update on his battle with the coronavirus.

During a Wednesday on-air interview with his brother, New York Gov. Andrew Cuomo, the CNN anchor revealed that his wife Cristina Greeven Cuomo has also tested positive for COVID-19.

"It's very rare for a family to be one-and-done," Cuomo said on his show "Cuomo Prime Time." "Cristina now has COVID. She is now positive, and it just breaks my heart. It is the one thing I was hoping wouldn't happen, and now it has."

His brother responded by describing the difficulty of self-isolating in a home shared by multiple people.

"It's very hard for a person to quarantine in a home and other people not to get infected. That's why we talked about people who quarantine in hotels," the governor said. "But to do it in a home, where a person is bringing you dishes, bringing you food. Even if they're wearing a mask and gloves, that virus can live on some surfaces up to two days."

During a press conference Thursday, the governor added that Cristina became infected because she was taking care of his brother.

"He's sick in the basement, Cristina's quarantined upstairs," Cuomo said. "It's a practical hardship, but he's feeling better."

During a Tuesday interview on his show with Dr. Sanjay Gupta, Cuomo said he had hoped to make it 72 hours off Tylenol with no fever, but developed a 101 degree temperature after just 60 hours.

"I have to be honest, I got a little cocky," Cuomo said. "I started thinking about, 'Oh great, I want to get retested and then I'm going to do this and I'm going to do that and I'm going to do this.' Not the way COVID works. … It comes in waves."

And the previous night, Cuomo expressed frustration with the fact that he couldn't shake the virus, despite some symptoms improving.

"I'm scared by this. I'm scared by the potential of this and it frustrates me because I can't get out of this basement," he said Monday. "Everybody tells me it's gradual, it takes time – anywhere from two to three-and-a-half weeks, but it is maddening to have this little, stupid fever."

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Cuomo said during the Monday show he sees himself as a "metaphor" for the rest of the United States hoping to get things back to normal: "I'm ready to get out of the basement. I'm sick of being sick. I've had it. I want to get back to work. But I'm not ready and I don't have a plan to be ready. That's where we are right now."

The anchor said coronavirus has also negatively affected his mental state.

"This virus creates emotional illness and creates psychological illness," he said. "I'm telling you: It is in my head. Not just figuratively in terms of messing with you because you're sick for a long time. It is causing people depression. And it's creating brain fog. And it's creating edginess in people. … I'm experiencing that. It messes with your head, this virus. And I don't know where it leaves you after."

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Cuomo also made headlines this week after expressing frustration over elements of his job, saying he was tired of interviewing disingenuous politicians and didn’t “value indulging irrationality, hyper-partisanship.” He added: “I don’t like what I do professionally.″

He since reaffirmed his commitment to CNN and his gratitude for his prime-time perch, adding he had no intention of leaving the network But he questioned how much of a difference he was making.

Cuomo clarified his comments Tuesday on his SiriusXM show, saying “it is frustrating to do this job in an environment where people are not interested and open. It is hard to practice journalism when people are so intent on believing what they want to believe for political advantage.”

The anchor said he’s been “rethinking a lot of things on an existential basis all the time" while isolated in his basement.

“I was talking about having legitimate questions,” he said. “Is the way I do this working? If it’s not working, can I do it differently, do I want to do it differently? Would that work?”

On March 31, Cuomo announced he had tested positive for COVID-19. Since then, the anchor has kept viewers updated in broadcasts from isolation, detailing his latest symptoms, which at times included hallucinations, profuse sweating, headaches, pains in his face and weight loss.

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"When the fever spikes you just want to curl up in a ball and stay there for the next six, seven hours and you can't. You've got to bundle up your clothes, you've got to start drowning yourself in fluid," Cuomo said on air last week.

He said he had begun to feel symptoms a few days before officially testing positive and knew "as an essential worker" that he needed to be tested, "because I was in the mix."

Contributing: Hannah Yasharoff