A cyclist was killed after a car pulled out of a driveway in the Dandenong Ranges on Saturday morning.

A Toyota Hilux was pulling out of a private driveway around 10.30am when it collided with two male cyclists travelling north on Mt Dandenong Tourist Road, Kalorama, said police.

One cyclist, a 50-year-old from Croydon, died at the scene. The other was taken to Royal Melbourne Hospital with minor injuries.

In a second fatal accident on Saturday, a man was killed after a motorcycle crash in Labertouche, east of Pakenham.

The motorbike left Labertouche North Road around 3.40pm and ended up on the other side of a small creek, said police.

The rider, believed to be aged in his 20s, was attended to by paramedics but died at the scene. Police will prepare a report for the coroner.

The deaths bring the state's road toll to 19, compared to 13 for the same time last year.