Marnus Labuschagne has gone big in notching his maiden Test ton with a swashbuckling 185 batting Pakistan out of the first Test in Brisbane.

State of play: Pakistan has an uphill battle for survival, after the top order faltered to be 3-64 at stumps, still trailing by 276

Pakistan has an uphill battle for survival, after the top order faltered to be 3-64 at stumps, still trailing by 276 Earlier, Australia lost 7-112 to be all out for 580, a lead of 340 on the first innings

Earlier, Australia lost 7-112 to be all out for 580, a lead of 340 on the first innings Marnus Labuschagne got within sight of a maiden double century, before falling for 185

At stumps on day three, Pakistan was 3-64, trailing Australia by 276 after the hosts were bowled out for 580 at the Gabba.

Mitchell Starc (2-25) had opener Azhar Ali out LBW for 1, before Haris Sohail (8) edged a poor shot behind.

Asad Shafiq (0) did not trouble the scorers before he nicked Pat Cummins (1-16) to slip, but the day belonged to the batsmen, particularly South African-born Labuschagne.

Mitchell Starc broke through early as Pakistan stared down a monstrous deficit. ( AAP: Darren England )

David Warner added just three runs to his overnight score before a Naseem Shah short ball followed him and he edged to the keeper for 154.

Labuschagne had already asserted himself as the primary run-scorer before Warner's dismissal, finding the boundary at will as Warner slowed down following day two's carnage.

The crowd got what they wanted to see when Steve Smith walked out to the middle, but it lasted mere minutes as Smith missed everything, trying to whip Yasir Shah (4-205) through the leg side, instead seeing his off stump cleaned up for 4.

Matthew Wade joined Labuschagne and they combined for 110 runs for the fourth wicket as Wade got his eye in early, belting seven fours and a six in an entertaining 60.

Wade's dismissal was a soft one, getting an edge to the keeper while playing back to the spin of Haris Sohail (2-75), but by then Australia was loving life at 4-468.

Marnus Labuschagne was gutted when he was finally dismissed on 185. ( AP: Tertius Pickard )

In the meantime, Labuschagne had reached his maiden ton off 161 balls, edging a drive to the third-man fence and punching the air with delight.

It capped a superb rise from cricketing prospect to near-certain Test pick since coming on as a concussion substitute for Smith in the recent Ashes tour.

Travis Head (24) came and went in a 29-ball knock before he succumbed to excellent keeping from Mohammad Rizwan, who anticipated the batsman's attempt to play the ball fine on the leg side, switching sides to take a sharp catch.

Tim Paine fell cheaply for 13, edging an awkward pull shot behind off Shaheen Afridi's (2-96) short-of-a-length ball, before Labuschagne finally fell to a thick edge to the slips cordon.

Starc was trapped plumb LBW by Yasir for 5, before Cummins (7) edged behind. Nathan Lyon fell for 13, trapped on his pads by Yasir, as Australia was dismissed 340 runs in front.

Look back at how the day unfolded in our live blog below.