The active ingredient in Differin Gel is a synthetic retinoid known as adapalene. First approved by the U.S. Food & Drug Administration in 1996, adapalene debuted as Differin, a sheer gel formula designed to treat acne and its symptoms in a slightly different (some would say more precise) way than previous-generation retinoids such as tretinoin, aka Retin-A.

After over 20 years of only being available by prescription, Differin was given approval to be sold over-the-counter. What you're getting is the original strength in the exact same ultra-light, opaque tube-packaged, fragrance-free formula, which is great.

What's not so great—and why this missed our top rating—is that Differin missed an opportunity to retool its original formula to make it even better for reducing acne.

As an example, the company could've added some proven soothing ingredients to better target redness. Despite this letdown, Differin's active ingredient can still make a big difference for many people struggling with acne and clogged pores. And of course, now you don't need to bother getting a prescription to see how Differin might work for your breakouts.

Just as with the prescription form (and note that stronger versions of Differin containing 0.3% adapalene remain available by prescription only), you're directed to apply a sheer layer of Differin Gel to cleansed skin once daily. As with any topical retinoid, pay close attention to how your skin responds, and adjust frequency of application as needed if you see redness, flaking, or signs of sensitivity.

In terms of cost, while the OTC version of Differin Gel is certainly less expensive than the prescription versions—including generic adapalene—there are other prescription retinoids available as generics that could end up costing less depending on the product and if you have a prescription coverage plan.

One more comment: Differin may be used with other topical anti-acne products, including those medicated with benzoyl peroxide and salicylic acid and/or other non-retinoid topical prescription products. Consult your physician or pharmacist for advice on how to combine use of OTC Differin with topical prescription acne products.

Pros: Ultra-light sheer gel texture is easy to apply and won't clog pores.

Can be used with other topical anti-acne treatments.

Fragrance free.