The Indianapolis Colts defense has been rounding into form over the past handful of weeks, but they are set to run into a buzzsaw in Tennessee Titans running back Derrick Henry for the Week 13 matchup at Lucas Oil Stadium.

A run defense that struggled at the beginning of the season, the Colts have been stout over the last four weeks. The unit hasn’t allowed more than 100 rushing yards to an opposing offense over that span.

However, defensive coordinator Matt Eberflus knows just what type of game they must have against Henry—the engine of the Titans offense.

“I just think his talent level and the way the offensive line is blocking for him. He’s a downhill runner and has a great ability to capture the edge. He also has the ability to cut back. It’s his style of running. He’s hard to get down and he creates a challenge,” Eberflus told reporters Tuesday.

Henry has been enjoying a career season in 2019. Finally getting the full workload, the Alabama product has been terrorizing the league with powerful and explosive runs.

On the season, Henry has taken 206 carries for 991 rushing yards and 10 touchdowns while averaging 4.8 yards per carry. He’s sixth in the NFL in rushing yards and fourth in rushing touchdowns. Henry has scored six total touchdowns over the last three games.

The Colts will also have to deal with the change at quarterback in Ryan Tannehill, but Henry is likely going to be the priority from the defensive side of the ball.

“Overall, their play-action pass is really good, their screen game is good and they are really good at the boots that complement the running game,” said Eberflus. “He’s a challenge every time we play him.”

This matchup is crucial for both teams trying to stay in the playoff hunt and for the Colts, that starts with keying on Henry as the top priority on the Titans offense.