In case you haven’t heard, “Avengers: Infinity War” is heading towards an opening weekend that could end all opening weekends.

The Marvel superhero adventure is eyeing a debut weekend of $225 million to $245 million, with a possibility of even crossing the $250 million mark. If numbers reach the end of that range, “Infinity War” could have one of the biggest debuts of all time. The hefty launch should go a long way to justify its wildly expensive price tag of somewhere from $300 million to $400 million.

As of now, the biggest opening weekend of all time belongs to “Star Wars: The Force Awakens,” which bowed with $248 million in 2015 and went on to make over $936.6 million domestically. Only five films in history have hit the $200 million mark in their debuts.

“Infinity War” picks up two years after the events of “Captain America: Civil War” with the Avengers teaming up with the Guardians of the Galaxy to stop the evil Thanos from inter-galactic dominance. The heroic ensemble cast includes Robert Downey Jr.’s Iron Man, Chris Hemsworth’s Thor, Chris Evans’ Captain America, Scarlett Johansson’s Black Widow, Chadwick Boseman’s Black Panther, Chris Pratt’s Star Lord, Benedict Cumberbatch’s Doctor Strange, and Mark Ruffalo’s Hulk.

Joe and Anthony Russo directed from a script by Christopher Markus and Stephen McFeely. “Infinity War,” the sequel to 2012’s “The Avengers” and 2015’s “Avengers: Age of Ultron,” is the 19th film in the Marvel Cinematic Universe.

The original “Avengers” had the highest opening to date for a Marvel film, debuting with $207.4 million. Its sequel, “Age of Ultron,” launched with $191 million. The first movie earned $623 million in North America, while the second made $459 million.

“Infinity War” comes on the coattails of the Disney-owned Marvel’s most recent success, “Black Panther,” which opened to a massive $202 million in February. Ryan Coogler’s tentpole continues to shatter records, and has earned an impressive $1.3 billion worldwide.

Naturally, no other studio considered a wide release for the superhero-intensive weekend. “A Quiet Place” will likely drop to the No. 2 slot in its fourth frame. The surprise hit, directed by John Krasinski and co-starring Krasinski and Emily Blunt, has made $131 million in North America. Other recent releases, such as Amy Schumer’s “I Feel Pretty” and Dwayne Johnson’s “Rampage” should also see drops as “Infinity War” will presumably gobble up the rest of the box office.