French President Emmanuel Macron addresses a news conference during European Union leaders informal summit in Brussels, Belgium, February 23, 2018. REUTERS/Francois Lenoir

PARIS (Reuters) - French President Emmanuel Macron has asked his Iranian counterpart Hassan Rouhani to put pressure on the Syrian government to end attacks against Syria’s besieged eastern Ghouta region and allow humanitarian aid to flow.

In a phone conversation on the eve of Foreign Minister Jean-Yves Le Drian’s trip to Tehran, the two presidents agreed to work together in the coming days with the United Nations, Damascus and other countries who are involved to improve the situation for civilians and make a ceasefire effective.

France also expects Iran to make a “constructive contribution” to solving crises in the Middle East, the presidency statement said.

Violence has escalated in eastern Ghouta, despite a U.N. ceasefire call a week ago and the bombing of the besieged Syrian enclave represents a “simply unacceptable” punishment of civilians, the United Nations said on Sunday.

Le Drian also said that Iran needed to address concerns over its ballistic missile program or risk new sanctions.

Iran said France’s concern over its ballistic missile program was “wrong”, the semi-official Fars News agency said.