New York (Reuters) - Wall Street’s three major indexes fell more than 4% on Wednesday, after President Donald Trump’s dire warning on the U.S. death toll from the coronavirus sent investors running from even the most defensive equities.

Trump warned Americans late Tuesday of a “painful” two weeks ahead and health officials highlighted research predictions of an enormous jump in virus-related deaths.

Economic data did little to lift the mood. While U.S. manufacturing activity contracted less than expected in March, new orders received to factories fell to an 11-year low. And business closures pushed private payrolls down by 27,000 jobs last month, the first decline since September 2017, according to the ADP National Employment Report.

But money managers mostly focused on Trump’s comments and those of New York Governor Andrew Cuomo, a state badly hit by the virus.

“With comments from President Trump and Cuomo suggesting this is going to get worse before it gets better, investors are coming to the realization the virus will be with us for longer than they would have expected,” said Chris Zaccarelli, Chief Investment Officer, Independent Advisor Alliance, Charlotte, NC.

“Because of that the bear market is going to last longer,” he said. “The longer people stay home the longer it takes for the economy to restart and the longer it takes for corporate earnings to come back.”

The Dow Jones Industrial Average .DJI fell 973.65 points, or 4.44%, to 20,943.51, the S&P 500 .SPX lost 114.09 points, or 4.41%, to 2,470.5 and the Nasdaq Composite .IXIC dropped 339.52 points, or 4.41%, to 7,360.58.

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Even sectors generally seen as the safer bets because of high dividends saw a stampede to the exits. Real estate .SPLRCR and utilities .SPLRCU each declined 6%, making them the leading percentage losers among the S&P's 11 major sectors.

Virus worries also heightened nerves over the upcoming earnings season which starts in roughly two weeks. Some companies have withdrawn their financial guidance.

“We don’t know all the economic and earnings impact yet and this is a sober thought for Americans with those projections of the death rate,” said John Augustine, chief investment officer at Huntington National Bank in Columbus, Ohio.

S&P 500 firms are expected to enter an earnings recession in 2020, falling 4.3% in the first quarter and 10.9% in the second, according to the latest estimates gathered by Refinitiv.

Consumer staples .SPLRCS, down 1.8%, fared the best of the S&P's sectors as many consumers have been stockpiling goods due to government directives to stay at home.

Shares of airlines and cruise operators were among the S&P's biggest laggards, with United Airlines UAL.O down 18.7% and Carnival Corp CCL.N plunging 33%.

Declining issues outnumbered advancing ones on the NYSE by a 9.47-to-1 ratio; on Nasdaq, a 7.15-to-1 ratio favored decliners.

The S&P 500 posted 1 new 52-week highs and 11 new lows; the Nasdaq Composite recorded 7 new highs and 91 new lows.

On U.S. exchanges 12.29 billion shares changed hands compared with the 15.81 billion average for the last 20 sessions.