A man and a woman have been stabbed after they confronted two intruders who were trying to get into their Glen Iris home.

The couple, aged in their 50s, were at home on Adrian Street when the two offenders came into the back garden about 4am.

A police spokeswoman said the couple confronted the pair and there was an altercation.

The residents were stabbed in the upper body and taken to hospital with non-life threatening injuries.