Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellFEC flags McConnell campaign over suspected accounting errors Poll: 59 percent think president elected in November should name next Supreme Court justice Mark Kelly: Arizona Senate race winner should be sworn in 'promptly' MORE (R-Ky.) said Friday night that the fight over Supreme Court nominee Brett Kavanaugh was a "wake-up call" ahead of the November midterm elections.

"It's a wake-up call to why it's important to hold the Senate. You know the Senate's in the personnel business," McConnell told Fox News's Laura Ingraham.

McConnell's comments come as the Senate is poised to confirm Kavanaugh to the Supreme Court on Saturday.

The expected vote will give Republicans their second Supreme Court victory in as many years and a significant win roughly a month before the midterm election.

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McConnell added on Friday night that he would use the fight over Kavanaugh's nomination to "remind everybody about the importance of the Senate" heading into the fall elections.

"These are lifetime appointments with conservative men and women who believe that the job of a judge is to interpret the law as its written," McConnell said.

Republicans are heading into November with a largely favorable map. Democrats are defending 10 seats in states won by President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE in 2016. Republicans, by comparison, are defending one seat in a state won by Hillary Clinton Hillary Diane Rodham ClintonDemocratic groups using Bloomberg money to launch M in Spanish language ads in Florida The Hill's Campaign Report: Presidential polls tighten weeks out from Election Day More than 50 Latino faith leaders endorse Biden MORE — Nevada, held by Sen. Dean Heller Dean Arthur HellerOn The Trail: Democrats plan to hammer Trump on Social Security, Medicare Lobbying World Democrats spend big to put Senate in play MORE (R).

Only one Democratic senator is expected to vote for Kavanaugh on Saturday, Sen. Joe Manchin Joseph (Joe) ManchinManchin defends Supreme Court candidate Barrett: 'It's awful to bring in religion' The Hill's Morning Report - Sponsored by Facebook - Trump, GOP allies prepare for SCOTUS nomination this week Trump meets with potential Supreme Court pick Amy Coney Barrett at White House MORE (D-W.Va.). Manchin, who is running for reelection in a state Trump won by 42 points, announced his support on Friday.

Democratic Sens. Heidi Heitkamp Mary (Heidi) Kathryn HeitkampHarris faces pivotal moment with Supreme Court battle Centrists, progressives rally around Harris pick for VP 70 former senators propose bipartisan caucus for incumbents MORE (N.D.) and Joe Donnelly Joseph (Joe) Simon DonnellyHarris faces pivotal moment with Supreme Court battle Trump meets with potential Supreme Court pick Amy Coney Barrett at White House Names to watch as Trump picks Ginsburg replacement on Supreme Court MORE (Ind.), who are also up for reelection in states won by Trump, both joined Manchin last year in voting to confirm Neil Gorsuch, Trump's first Supreme Court nominee.

Heitkamp and Donnelly have both said they will vote against Kavanaugh.