ROME — Pope Francis has accepted the resignation of Cardinal Theodore E. McCarrick, the former archbishop of Washington, from the College of Cardinals, ordering him to a “life of prayer and penance” after allegations that the cardinal sexually abused minors and adult seminarians over the course of decades, the Vatican announced on Saturday.

Acting swiftly to contain a widening sex abuse scandal at the highest levels of the Roman Catholic Church, the pope officially suspended the cardinal from the exercise of any public ministry after receiving his resignation letter Friday evening. Pope Francis also demanded in a statement that the prelate remain in seclusion “until the accusations made against him are examined in a regular canonical trial.”

Cardinal McCarrick appears to be the first cardinal in history to step down from the College of Cardinals because of sexual abuse allegations. While he remains a priest pending the outcome of a Vatican trial, he has been stripped of his highest honor and will no longer be called upon to advise the pope and travel on his behalf.

A prominent Roman Catholic voice in international and public policy, Cardinal McCarrick was first removed from public ministry on June 20, after a church panel substantiated allegations that he had sexually abused a teenage altar boy 47 years ago while serving as a priest in New York.