Lobbyists, public relations consultants, and the usual special interests types who infest the halls of power inside the Beltway are in meltdown mode now that Donald Trump has effectively secured the GOP nomination.

After Trump’s decisive Indiana victory, GOP lobbyists and Establishment standard-bearers are now faced with coming to terms with this notion: The former GOP sacred cows of free trade and foreign intervention could be slaughtered under a Trump presidency or in a GOP dominated by populists.

They’re not handling it very well.

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“As a Republican, I’m depressed,” said Tom Korologos, a strategic adviser for the law firm DLA Piper.

Korologos, who served as the ambassador to Belgium during the George W. Bush administration, met with other lobbyists on Wednesday and noted that “they were all depressed.”

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“A lot of people woke up and went, ‘Oh, gosh, this is not a dream,'” said Jeff MacKinnon, principal and co-founder of Farragut Partners. “I don’t think Downtown [Washington] was really prepared for it happening so quickly. It did catch people off guard.”

“Everyone is scrambling for relevancy right now,” MacKinnon continued. “Everyone wants to be a player on some level, but they don’t even have a uniform on right now — they’re still trying to figure out which one to wear, or if they’ll even be put in the game.”

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But the cloud of uncertainty covering K Street is clearly mixed with a significant dose of fear.

“He’s going to have a hard time coalescing the support that the business community has typically given to the nominee,” one lobbyist told The Hill, speaking anonymously.

His “policies are tough to deal with, but when you add on to that the temperament and the foreign policy stuff, it’s a lot for people to work through,” the lobbyist added.

It’s not surprising that the complete and utter destruction of GOP “business as usual” has K Street rattled. Trump has not only spoken out repeatedly against the negative influence of K Street money, but also threatens to change irrevocably the sociopolitical orientation of the GOP.

A few lobbyists, however, have warmed up to Trump. David Urban, president of the lobbying firm American Continental Group, even began campaigning for Trump last week.

“You don’t need to have unanimity to have unity in our party,” said Urban. “I think the base and the party is going to get behind him pretty quickly.” he said.

But “what a Trump administration would mean for K Street? I think people are worried about winning the White House. I think that’s what Republicans on K Street should be worried about.”