The Lady in Grey – Hair Loss From Low Stomach Acid

by Jeffrey Dach MD

Mary is a 62 year old accountant who arrived in my office with a chief complaint of hair loss. Mary was dressed smartly, wearing a grey suit. Not only that, but her skin tone was also a peculiar grey color matching the color of her suit. Upper Left Image: Lady Jane Grey, engraving Date 1620, by Willem van de Passe, courtesy of Wikimedia Commons

Mary arrived in my office with a large bag of vitamins for her hair, which included biotin, and Chinese herbs (shin bet). She had been to dermatologists and hair loss doctors who gave her creams and shampoos. Nothing seems to be helping. Mary sat down and told me her story.

Mary had been doing fine until about two years ago when she had experienced a stressful family event when her mom passed away. Shortly after that she noticed her hair thinning and falling out. She also noticed leg cramps at night which wake her up. She has gas and bloating after meals, and finds that many foods don’t agree with her.

Mary’s nails were soft and peeling, and there were patches of absent or thinning hair on her scalp. Mary’s tongue was red and beefy (Hunter’s Glossitis from low B12). We gave Mary a lab sheet and sent her to the lab for blood work. The lab panel showed low B12, low Iron, Low Ferritin, low magnesium, low selenium and borderline anemia, and Mary’s serum gastrin was elevated, a finding diagnostic for hypochlorhydia (low stomach acid). This explained Mary’s hair loss and other symptoms.

Mary’s story reminded me of “the Grey Man”, a patient seen by Jonathan Wright MD who had peculiar grey skin tone and severe fatigue from years of acid blocker drug use.

This “Grey Man” story can be found in the book: “Why Stomach Acid Is Good for You: Natural Relief from Heartburn, Indigestion, Reflux and GERD” by Jonathan Wright, MD and Lane Lenard, PhD (Amazon Listing). We keep a few of these books in the office for patients to borrow and read.

Mary wasn’t taking any acid blocking drugs. Instead, Mary had gastric atrophy causing the low acid production, a common condition in which the acid producing cells of the stomach lining gradually disappear, leaving behind a stomach unable to produce much gastric acid.

Why We Need Stomach Acid

You might then ask:

“Well, So What ?, We don’t need gastric acid anyway because millions of people are on gastric acid blocking drugs handed out freely by the medical profession”.

Unfortunately this is wrong. The body does need gastric acid. Without gastric acid we are unable to digest and absorb proteins, vitamins and minerals. The minerals are iron, calcium, magnesium, selenium and zinc. Without gastric acid we are unable to absorb vitamins like B12, thiamine and folate. Without gastric acid we are unable to digest and absorb amino acids for protein production. This leads to inability to form collagen, hair loss and muscle loss. Gastric acid plays a huge role in sterilizing our food and protecting us from infection. Low gastric acid allows for candida overgrowth, and gut dysbiosis as well as chronic GI parasites. Low gastric acid leads to large undigested food particles entering the circulation through the “leaky gut” and causing an immune response which may lead to multiple food allergies, and autoimmune diseases.

Symptoms of Low Gastric Acid

1) Belching, bloating, burning, or “acid reflux” after eating, immediately after meals.

2) a sense of fullness after eating.

3) Indigestion and constipation because food is not being digested properly

4) Skin conditions such as Acne, Rosacea, Urticaria, Eczema

Dilated blood vessels in the cheeks and nose (in non-alcoholics), this is called “Rosacea Acne

5) Vertical ridging on the nails because of inability to absorb nutrients from food, Weak, peeling, and cracked fingernails.

6) Leg and foot cramps from mineral deficiencies because you are not absorbing minerals.

7) Chronic injuries due poor amino acid status and inability to restore tissue, muscle atrophy and wasting.

8) Multiple Food allergies, which may be associate d with asthma.

9) Gallstones. You may have already had a cholecystectomy.

10) Poor cognitive function and the onset of dementia.

11) Low bone mineral density and osteoporosis.

12) Itching around the rectum from parasites.

Diseases Associated with Low Gastric Acid

Addison’s disease

Anemia-Iron Deficiency

Asthma – see the Jonathan Wright Book for a discussion of proper treatment of asthma in children with B12 injections, B6 Magnesium, avoiding food allergens and addressing low gastric acid.

Celiac disease – Wheat gluten sensitivity – Enterolabs, Cyrex labs, antigliadin antibody

Chronic autoimmune disorders-entire list of autoimmune diseases

Chronic hives

Cognitive Dysfunction and Dementia from B12 deficiency

Dermatitis herpetiformis (herpes)-typical for wheat gluten sensitivity

Depression- Leaky Gut with LPS (see articles by Michael Maes)

Diabetes – Autoimmune type one

Eczema

Gall bladder disease – associated with hypochlorhydia

Graves disease-Autoimmune-Elevated TSH receptor ab-Yersinia molecular Mimciry with TSH receptor

Hepatitis

Iron deficiency-Low Iron and Low ferritin

Hyper and hypothyroidism- Autoimmune-Hashimotos Thyroiditis

Lupus erythematosus -autoimmune

Myasthenia gravis

Neuropathy and NeuroPsychiatric Disorder from B12 deficiency

Osteoporosis-from Calcium Malabsorption

Pernicious anemia – Parietal Cell Antibodies-B12 deficiency-gastric atrophy

Psoriasis-autoimmune

Rheumatoid arthritis-autoimmune

Rosacea

Sjögren’s syndrome – Autoimmune

Thyrotoxicosis-three types: Graves, Hashitoxicosis, and Txic Nodular Goiter

Vitiligo

Chronic intestinal parasites or abnormal flora -GI-Fx shows parasite DNA

Undigested food in stool-Demonstrated on GI-FX test

Chronic candida infections-from gut dysbiosis

Upper digestive tract gassiness-from dysbiosis

Testing for Low Stomach Acidity -Diagnosis of Low Gastric Acid

The Heidelberg Capsule

Jonathon Wright MD uses the Heidelberg capsule at the Tahoma Clinic to measure gastric acid. The patient swallows a small disposable oral capsule containing a pH meter and radio-telemetry device. This is the most accurate and direct way to measure gastric acid. Dr. Wright has done this on literally thousands of patients, laying the ground work for his book on “Why You Need Gastric Acid.”

Indirect Lab Tests Useful in Detecting Low Gastric Acid

Indirect lab tests may be useful. Serum gastrin is elevated in patients with low gastric acid. Serum amino acids, B12, Iron, Ferritin and Hbg/Hct may be low from malabsorption. Serum Triglycerides may be low indicating fat malabsorption. Stool testing (GI-Fx) may show dysbiosis with overgrowth of candida, parasites or incomplete digestion with Fat and Protein malabsorption.

Treatment of Low Gastric Acid- Without Drugs

Treatment of low gastric acid is done with natural supplements and without drugs, explaining why mainstream medicine is blind to this diagnosis and treatment.

Mainstream medicine docs will never measure gastric acid. Instead, mainstream docs merely assume the problem is excess stomach acid, and then prescribe acid blocking drugs like the proton pump inhibitors, Prilosec, Nexium, Tagamet, etc. As you know by now, acid blocking drugs are not the answer to a low gastric acid condition , and will merely make the patient worse.

Betain HCL with Pepsin, Digestive Enzymes, Probiotics

Acid replacement is readily available from the health food store as Betain HCL with Pepsin. The Betaine HCL capsules are taken with meals according to a Schedule Sheet which we review and hand out at the office. The sheet can be found Here:Testing_Low_Stomach_Acidity

Self-testing and treatment for low HCl / Hypochlorhydria:

1. Begin by taking one capsule of Betaine HCl/Pepsin with a large meal containing fat and protein. A normal response in a healthy person would be discomfort—basically a heartburn feeling. If you do not feel a burning sensation, at the next meal, start taking two capsules with each large meal.

2. If there are no adverse “heartburn feelings” or other discomfort after two days, then increase the number of capsules with each meal to three capsules.

3. Continue increasing the number of capsules every 2 days, using up to eight capsules with each meal if necessary. These dosages may seem large, but a normally functioning stomach manufactures considerably more. You’ll know you’ve taken too much if you experience tingling, heartburn, diarrhea, or any type of discomfort including a feeling of unease, digestive discomfort, neck ache, backache, headache, or any new odd symptom. If you experience tingling, burning, or any symptom that is uncomfortable, you can neutralize the acid with 1 tsp baking soda in water or milk.

4. When you reach a state of tingling, burning, or any other type of discomfort, cut back by one capsule per meal. If the discomfort continues, discontinue the HCl and consult with your healthcare professional.

5. Once you have established a dose (either 8 capsules or less, if warmth or heaviness occurs), continue this dose.

6. With smaller meals, you may require less Betaine HCl so you may reduce the amount of capsules taken.

7. Individuals with very moderate HCl deficiency generally show rapid improvement in symptoms and have early signs of intolerance to the acid. This typically indicates a return to normal acid secretion.

8. Individuals with low HCl/pepsin typically do not experience such quick improvement, so to maximize the absorption and benefits of the nutrients you take, it is important to be consistent.

Treatment with Apple Cider Vinegar

A milder form of treatment is with the acid, apple cider vinegar, one tablespoon taken before each meal. Use the raw/unpasteurized Apple Cider Vinegar. The apple cider vinegar commonly found in supermarkets is usually pasteurized.

Braggs or something similar at the health food store is a good bet. Besides being unpasteurized, it may be unfiltered with floating particulate matter, called the mother which causes the vinegar to ferment, and isn’t harmful.

How to take your Apple Cider Vinegar

Start with a small amount, a teaspoon or half a teaspoon in a glass of water and drink. After a few days, gradually increase to one or two tablespoons before each meal. If you continue more than two weeks,, drink through a straw to avoid fental exposure to the acid.

Link to Basic Supplement for Hair Skin and Nails:

Buy Hair/Skin/Nails Ultra by Pure Encapsulations

Buy DIgestive Enzyme w/Betaine HCL direct from Purecaps

Other Hair Loss Strategies:



Tocotrienol Vitamin E was found to increase hair growth in a 2010 study by Dr. Beoy.(16)

Testosterone (DHT) Blocking Drugs for androgenic alopecia in females: Spironolactone with topical Minoxidil (17-22)

Phyotherapy with Saw Palmetto, a 5-alpha reductase inhibitor which inhibits conversion of testosterone to DHT, has been found effectivc for androgenic alopecia in females. (23-34)

Articles with related interest

Heartburn, GE Reflux (GERD), and Acid Blocker Drugs

The Grocery Store as Mine Field, Avoiding the Dangers

Selling Sickness in the Lobby, Fast Food in Hospitals

Jeffrey Dach MD

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Links and References

PDF FILE Testing for Low Stomach Acidity

1) www.funmedidaho.com/wp-content/uploads/2011/03/Testing_Low_Stomach_Acidity.pdf

Self-testing and treatment for low HCl/hypochlorhydria

2) www.jointspinecenter.com/files/TestingforLowStomachAcidity.pdf

Testing for Low Stomach Acidity

3) drnatashaturner.com/wp-content/uploads/2010/08/Clear-MedicineHCL-challenge.pdf TAKE THE HCL CHALLENGE This simple test can help you determine whether you have the appropriate level of hydrochloric acid in your stomach for optimal digestion Maximize Your Progress with Hydrochloric Acid

4)360optimalfitness.com/articles/Hydrochloric_Acid.pdf www.life-enthusiast.com/hydrochloric-acid-a-1331.html

Hydrochloric Acid by Kelly – Gregory S. video of jonathan wright

5)nutritiongang.com/low-stomach-acidity-hypochlorhydria/

99% of the Time it is Low Stomach Acidity (Hypochlorhydria) Which Causes Heartburn and Acid Reflux – Antacids Make The Problem Worse! Source

6) nutritiongang.com/low-stomach-acidity-hypochlorhydria/

How To Test For Hypochlorhydria At Home

There are a variety of simple at-home tests available that can help patients self-diagnose Hypochlorhydria, as well as advanced diagnostic procedures that are performed by a licensed medical practitioner.

Here are the two most commonly-used home tests for low stomach acid:

The “Lemon Test”

One of the simplest ways to test for low stomach acid in the comfort of your own home is known as the “lemon test.” When you are suffering from stomach discomfort, simply place a teaspoon of lemon juice in 2-4 ounces of water and drink the mixture. If there is not enough acid in your stomach, the addition of the acid-filled lemon juice mixture will provide you with relief from your symptoms. In people with too much stomach acid, drinking acidic beverages like lemon water will make digestive discomfort worse.

Testing For Hypochlorhydria Using Betaine Hydrochloride (Betaine HCL)

According to Dr. Natasha Turner, a Toronto, Canada-based Naturopathic Doctor, best-selling author and regular guest of the Dr. Oz Show, the following is a simple test that can be used at home to test for low stomach acid”

Note: People who have ulcers should NOT attempt this test: Prepare for the test by purchasing Betaine Hydrochloride, also known as BH, HCL or Betaine HCL capsules. Look for BH which has been produced by a reputable supplement company and be sure not to confuse BH with Betaine Anhydrous, a product used to treat some rare genetic disorders.

Betaine Hydrochloride (BH) is an over-the-counter supplement that contains hydrochloric acid; it is sold in most pharmacies, health stores and online supplement retailers.

Prior to eating your largest meal of the day which includes a portion of protein, take one capsule or tablet of BH. Shortly afterwards, you should feel a warm, slightly burning sensation throughout your stomach. This indicates that the BH has activated the existing acid in your stomach, letting you know that your naturally-occurring levels of stomach acid are sufficient. (Burning, stomach pain, acid stomach, nauseousness/queasiness, constipation, loose stool, burning stool or rectum, acid reflux can all be symptoms of taking too much HCL.)

Patients who feel no effects whatsoever after taking a single dose of BH should repeat the above process the following day prior to their largest meal, however, the dose should now be increased to two tablets or capsules of BH.

Once again, pay attention to any warming or burning sensations in the stomach or digestive tract. If you feel a warm sensation in your stomach after taking two BH tablets, repeat the procedure the next day before your main meal, reducing the dose back down to one tablet or capsule.

Dr. Turner advises that patients continue this course of treatment (taking one tablet of BH prior to the largest meal each day) until a feeling of warmth or burning occurs after taking the supplement. This warming sensation indicates that there is enough acid in the stomach to support healthy functions without the need for supplementation with BH. She advises that patients should then begin taking a digestive enzyme product prior to each meal to help maintain a healthy digestive system.

What It Means If You Feel Nothing After Taking Two Pills of Betaine Hydrochloride

Dr. Turner advises that people who have relatively sufficient levels of naturally-occurring stomach acid will feel a warm, mildly burning sensation in their stomach after taking one or two doses of BH. However, people who suffer from low stomach acid will require larger doses of BH to activate their stomach acid, a definitive sign of low stomach acidity. If you follow the above BH/meal protocol and do not feel these sensations, take one additional pill of BH prior to your largest meal each day until you do feel a warm, burning sensation in your abdomen, up to a maximum of 10 BH pills per day.

According to Dr. Turner, the amount of BH supplementation it takes to elicit a symptomatic response (warmth and burning in the digestive tract) is relative to the severity of the patients’ Hypochlorhydria – the lower the levels of naturally-occurring stomach acid are, the greater the dose of BH needs to be to activate the heartburn symptoms. Simply put, if you test yourself for low stomach acid by taking one, then two, tablets of BH prior to eating a meal and you do not feel any sort of warming or burning sensation in your stomach or digestive tract, you can be relatively certain that you are suffering from Hypochlorhydria (low stomach acid). Dr. Turner further discusses that effectively treating low stomach acidity requires strict adherence to a regiment of BH supplementation for an extended period of time: Correcting a hydrochloric acid deficiency may take a few weeks or even months.

7) www.ndhealthfacts.org/wiki/Hypochlorhydria_%28Low_Stomach_Acid%29 Hypochlorhydria (Low Stomach Acid)

People with low stomach acid usually have a number of the following symptoms/signs. Stomach aching/pain/discomfort or bloating after meals Feel unwell/fatigued right after meals Food or water ‘sits in stomach’ High fat foods cause nausea/stomach upset Undigested food in stool Reflux &/or heartburn Poor appetite or feel overly full easily Multiple food sensitivities Trouble digesting red meat Constipation Low iron levels Frequent nausea Nausea/reflux after supplements (e.g. fish oil) Burping after meals

The Adverse Effects of Hypochlorhydria These include:

Malnutrition

a. amino acid deficiencies due to poor digestion and assimilation of protein. Low grade amino acid deficiencies can be associated with muscle wasting, immuno-deficiency, nervous system dysfunction and reduce liver detoxification.

b. multiple mineral deficiencies particularly of calcium, iron, magnesium and possibly selenium, chromium, manganese, copper and other trace minerals. Deficiencies of these minerals can further cause ill health and increased risk to degenerative diseases.

c. vitamin B12 deficiency. This is particularly seen in achlorhydric patients where there is no production of intrinsic factor. This is a chemical compound produced by the stomach which tags onto vitamin B12 released from protein in the stomach and carries it down the intestine to allow B12 to be absorbed in the lower part of the small intestine.

Food Intolerances

When protein is poorly digested, partially digested fragments can gain access to the body and initiate an activation of the immune system causing conditions associated with food intolerance, e.g. arthritis, rhinitis, asthma, eczema, urticaria (hives) and colitis.

Colon Toxicity

An increased lead of undigested protein fragments can get to the colon and feed a section of the flora there which overgrow, produce poisonous substances (like ammonia and various biogenic aminos) which are toxic to the body if allowed access to the general circulation. This is called putrefaction of the bowel.

Conditions Associated with Hypochlorhydria

These are numerous and include:

Patients with auto immune disease.

These diseases include

Type 1 diabetes,

thyroiditis,

lupus erythematous,

rheumatoid arthritis,

pernicious anemia,

multiple sclerosis and so on.

Clinical observation has elucidated that hypochlorhydria is present in 90% of lupus, 80% in rheumatoid arthritis and 60% in multiple sclerosis. Patients on gastric acid inhibitory drugs and antacids are often hypochlorhydric before they even started these drugs in about 90% of the cases!

Asthma, especially in childhood. The incidence is around 80%.

Osteoporosis. In 90% of patients, as those patients with hypochlorhydria cannot assimilate calcium and other minerals well which are vital for bone integrity.

Signs and Symptoms of Low Stomach Acid

Capillary dilatation in the cheeks. This gives a rosy red complexion. There is a very high correlation with gastric hypoacidity, especially in younger persons.

Fingernails that break easily. This is generally seen in women. Nails tend to be paper thin, crack, chip or layer back.

Hair loss in women. One also sees this in women who are pregnant, on oral contraceptive pills or estrogen replacement therapy and in folic acid deficient individuals.

Abdominal bloating, in the upper part with consumption if animal protein, especially beef, when food just “sits there like a rock” and doesn’t “digest” well.

Burping and belching.

Constipation.

8) www.wholehealthchicago.com/4370/a-disgusting-taste-in-her-mouth/

A Disgusting Taste in Her Mouth David Edelberg, MD

9) www.ncbi.nlm.nih.gov/pmc/articles/PMC2773890/

World J Gastroenterol. 2009 November 7; 15(41): 5121–5128.

Pernicious anemia: New insights from a gastroenterological point of view Edith Lahner and Bruno Annibale Edith Lahner, Bruno Annibale, Department of Digestive and Liver Disease, University Sapienza, 2nd Medical School, Ospedale Sant’Andrea, Via di Grottarossa 1035, 00189 Roma, Italy

10) drmyhill.co.uk/wiki/Hypochlorhydria_-_lack_of_stomach_acid_-_can_cause_lots_of_problems

Hypochlorhydria – lack of stomach acid – can cause lots of problems

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Betaine HCL

11) scdlifestyle.com/2012/03/3-tests-for-low-stomach-acid/

3 Tests for Low Stomach Acid by Steven Wright

12) scdlifestyle.com/2012/06/hypochlorhydria-3-common-signs-of-low-stomach-acid/ Hypochlorhydria:

3 Common Signs of Low Stomach Acid by Steven Wright

Conventional vs. Natural Heartburn Remedies –

How to Test for Hypochlorhydria to Determine the Best Treatment Should I choose the conventional purple pill or natural heartburn remedies? Before you decide, learn why testing your stomach acid levels for hypochlorhydria can be beneficial.

13) www.townsendletter.com/July2004/unseenepidemic0704.htm

The Unseen Epidemic: The Linked Syndromes of Achlorhydria and Atrophic Gastritis by Dr. Nigel Plummer

1) Belching, bloating, or “acid reflux” after eating

2) Indigestion and constipation because food is not being digested properly

3) Skin conditions such as acne

4) Vertical ridging on the nails because of inability to absorb nutrients from food

5) Leg and foot cramps because you are not absorbing minerals

6) Chronic injuries due poor amino acid status and inability to restore tissue

7) Food allergies and asthma

8) Gallstones

9) Poor cognitive function and the onset of dementia

10) Low bone mineral density and osteoporosis

14) www.selfgrowth.com/articles/Control_Autoimmune_Diseases_With_Stomach_Acid.html Control Autoimmune Diseases with Stomach Acid? By Marcus Laux, ND Marcus Laux, ND, is a licensed naturopathic physician who earned his doctorate at the National College of Naturopathic Medicine in Portland, Oregon.

15) The Whole Journey Stomach Acid Acne Christa Orecchio

16) Beoy, Lim Ai, Wong Jia Woei, and Yuen Kah Hay. “Effects of tocotrienol supplementation on hair growth in human volunteers.” Tropical life sciences research 21.2 (2010): 91.

The number of hairs of the volunteers in the tocotrienol supplementation group increased significantly as compared to the placebo group, with the former recording a 34.5% increase at the end of the 8-month supplementation as compared to a 0.1% decrease for the latter. Nevertheless, the cumulative weight of 20 strands of hair clippings did not differ much from the baseline for both supplementation groups at the end of the study period. In conclusion, this trial demonstrated that supplementation with tocotrienol capsules increases hair number in volunteers suffering from hair loss as compared to the placebo group. This observed effect was most likely to be due to the antioxidant activity of tocotrienols that helped to reduce lipid peroxidation and oxidative stress in the scalp, which are reported to be associated with alopecia.

17) Rathnayake, Deepani, and Rodney Sinclair. “Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss.” Dermatologic clinics 28.3 (2010): 611-618.

Since the serendipitous discovery 20 years ago that spironolactone given to a woman for polycystic ovary syndrome (PCOS) and associated hypertension also improved hirsutism, it has been used as a primary medical treatment for hirsutism. Spironolactone both reduces adrenal androgen production and exerts competitive blockade on androgen receptors in target tissues. Spironolactone has been used off-label in FPHL for over 20 years. It has been shown to arrest hair loss progression with a long-term safety profile. A significant percentage of women also achieve partial hair regrowth. Spironolactone is not used in male androgenetic alopecia because of the risk of feminization.

18) Burns, Laura J., et al. “Spironolactone for treatment of female pattern hair loss.” Journal of the American Academy of Dermatology 83.1 (2020): 276-278.

19) Sinclair, Rodney D. “Female pattern hair loss: a pilot study investigating combination therapy with low‐dose oral minoxidil and spironolactone.” International Journal of Dermatology 57.1 (2018): 104-109.

20) Hoedemaker, Carlijn, Sylvia Van Egmond, and Rodney Sinclair. “Treatment of female pattern hair loss with a combination of spironolactone and minoxidil.” Australasian journal of dermatology 48.1 (2007): 43-45.

21) Yazdabadi, Anosha, Jack Green, and Rod Sinclair. “Successful treatment of female‐pattern hair loss with spironolactone in a 9‐year‐old girl.” Australasian journal of dermatology 50.2 (2009): 113-114.

22) Shannon, Famenini, et al. “Demographics of women with female pattern hair loss and the effectiveness of spironolactone therapy.” Journal of the American Academy of Dermatology 73.4 (2015): 705.

23) Chatterjee, S., and S. K. Agrawala. “Saw palmetto (Serenoa repens) in androgenic alopecia An effective phytotherapy.” (2003).

24) Farris, Patricia K., M. D. Nicole Rogers, and M. D. Amy McMichael. “A Novel Multi-Targeting Approach to Treating Hair Loss, Using Standardized Nutraceuticals.” Journal of Drugs in Dermatology 16.11 Suppl (2017): s141-148.

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Jeffrey Dach MD

7450 Griffin Road, Suite 190

Davie, Fl 33314

954-792-4663

www.jeffreydachmd.com

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