The Uranium Producers of America, an industry group, is pushing the Environmental Protection Agency to withdraw regulations proposed by the Obama administration to strengthen groundwater protections at uranium mines. Mining groups have also waged a six-year legal battle against a moratorium on new uranium mining on more than a million acres of land adjacent to the Grand Canyon.

For the Navajo, the drive for new mines is a painful flashback.

“Back then, we didn’t know it was dangerous — nobody told us,” Mr. Holiday said, as he pointed to the gashes of discolored rocks that mark where the old uranium mines cut into the region’s mesas. “Now they know. They know.”

Supporters of the mining say that a revival of domestic uranium production, which has declined by 90 percent since 1980 amid slumping prices and foreign competition, will make the United States a larger player in the global uranium market.

It would expand the country’s energy independence, they say, and give a lift to nuclear power, still a pillar of carbon-free power generation. Canada, Kazakhstan, Australia, Russia and a few other countries now supply most of America’s nuclear fuel.

The dwindling domestic market was thrust into the spotlight by the contentious 2010 decision under the Obama administration that allowed Russia’s nuclear agency to buy Uranium One, a company that has amassed production facilities in the United States. The Justice Department is examining allegations that donations to the Clinton Foundation were tied to that decision.

“If we consider nuclear a clean energy, if people are serious about that, domestic uranium has to be in the equation,” said Jon J. Indall, a lawyer for Uranium Producers of America. “But the proposed regulations would have had a devastating impact on our industry.”