A motorcyclist has been killed in a hit and run incident on Mitchell Freeway.

A white Hilux utility travelling north at Leederville hit the motorcycle, dragging it for some distance along the freeway about 4.45pm.

Traffic is expected to be affected for several hours. Credit:Silvana Sukoski/Ten News Perth

The utility, registration 1CQA735, may have exited at Cedric Street.

Major traffic delays can be expected and motorists are advised to avoid the area.

The freeway is closed between the Leederville train station and the Vincent Street exit and will likely remain closed for several hours.