Residential and commercial buildings of Wuhan in China's central Hubei province. HECTOR RETAMAL/AFP/Getty Images

A California-bound flight chartered by the US State Department is scheduled to depart Wuhan Tianhe International Airport on Wednesday morning local time, a State Department official told CNN.

Stopping to refuel: The plane will stop to refuel at Ted Stevens International Airport in Anchorage, Alaska, before arriving in Ontario, California, about 35 miles east of downtown Los Angeles.

Who's on board: About 240 Americans are expected to arrive in Anchorage, Alaska Department of Health and Social Services spokesman Clinton Bennett said. About three dozen US diplomats and their families are also expected to be on board, a US official with knowledge of the matter told CNN Saturday.

Priority has also been given to US citizens who are "most at risk for contracting coronavirus" if they stay in city, the State Department official said. There are about 1,000 Americans living in Wuhan.

"All passengers will be subject to CDC screening, health observation, and monitoring requirements," the State Department said in a statement.

How Ontario is preparing: Ontario Airport said in a statement Monday it has been working closely with federal, state, county and city partners to prepare for the arrival of the Wuhan flight. The airport has "conducted extensive training in managing situations such as this" and health, safety and security preparations are underway ahead of the flight's planned arrival, the statement read.

Ontario Airport will operate under normal operations during the flight's arrival, and the facility is taking steps to minimize risk to other travelers, staff, and the community, the statement read.

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