A man has been killed and another left seriously injured following a horror machete attack in Melbourne on Saturday night.

Police have reported a brawl broke out between two groups of men on Castley Crescent, in Braybrook, around 9.30pm.

A car full of machete-wielding men allegedly used their vehicle to hit the two men, before assaulting them with weapons.

A man has been killed and another left seriously injured following a horror machete attack in Melbourne on Saturday night

The gang of four to six men are believed to be of African appearance.

The violent offenders then fled the scene in a silver or grey hatchback, striking both victims as they left.

A 40-year-old man was taken to hospital with life threatening injuries, where he later died.

A 44-year-old man was also taken to hospital with life threatening injuries.

Anyone who witnessed the incident or with any information is urged to contact Crime Stoppers on 1800 333 000.