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North Carolina A&T (2-0) at Charlotte (0-2), 6 p.m. ET

Charlotte only scored seven points in losses to both Eastern Michigan and Kansas State. North Carolina A&T, which blew out its first two opponents, will present a considerable challenge for the 49ers. Charlotte will stave off the upset thanks to dual-threat quarterback Hasaan Klugh, though.

Prediction: Charlotte 27, North Carolina A&T 24

Colgate (1-1) at Buffalo (0-2), 6 p.m. ET

Defense hasn't been a problem for Buffalo, since the unit limited Minnesota and Army to fewer than five yards per play on the road. Expect more of the same when Colgate comes to town. Moving the ball more consistently will get the Bulls over the hump against a solid FCS opponent.

Prediction: Buffalo 24, Colgate 16

Bethune-Cookman (1-1) at Florida Atlantic (0-2), 6:30 p.m. ET

Bethune-Cookman is absolutely capable of putting a scare into Florida Atlantic. BCU quarterback Larry Brihm Jr. accurately tossed short passes against Miami and threw for 354 yards in his second start. FAU should finally get its running game on track, which will be the difference in a contested finish.

Prediction: Florida Atlantic 31, Bethune-Cookman 23

Kent State (1-1) at Marshall (1-1), 6:30 p.m. ET

While nobody expected Kent State to compete with Clemson, the Golden Flashes allowed a few too many yards for comfort against Howard. Yes, the FCS squad had just shocked UNLV, but it doesn't bode well for Kent State's outings with quality offenses like Marshall. Chase Litton and Co. will jump ahead early and hang on.

Prediction: Marshall 37, Kent State 24

Southern Miss (1-1) at Louisiana-Monroe (0-1), 7 p.m. ET

Louisiana-Monroe gave Memphis a four-quarter test before falling 39-27. Was that simply a bad day for Memphis, or did ULM improve immensely during the offseason? Southern Miss is the better team and should record a road victory, but this is a statement opportunity for the Warhawks.

Prediction: Southern Miss 37, Louisiana-Monroe 27

Southern (1-1) at UTSA (1-0), 7 p.m. ET

Baylor's offense has been far less successful than expected, but UTSA had a wonderful performance against the Bears in Week 2. The Roadrunners should be able to carry over that defensive effort against Southern, which has only scored 14 total points in two games.

Prediction: UTSA 34, Southern 7

Arkansas-Pine Bluff (1-1) at Arkansas State (0-1), 7 p.m. ET

Nebraska isn't a great team, but putting up 36 points on the Cornhuskers was a commendable performance. Behind quarterback Justice Hansen, Arkansas State will painlessly navigate an Arkansas-Pine Bluff team coming off a 49-point loss to Akron.

Prediction: Arkansas State 45, Arkansas-Pine Bluff 13

Idaho (1-1) at Western Michigan (0-2), 7 p.m. ET

Giving up 357 rushing yards to UNLV is not an encouraging sign for Idaho prior to meeting Western Michigan, which piled up 263 yards on the ground against USC. The Vandals won't enjoy the trip to Kalamazoo unless they force a couple of fumbles.

Prediction: Western Michigan 37, Idaho 20

Alabama A&M (0-2) at South Alabama (0-2), 7 p.m. ET

"Overpowered and outmatched" is the story of September for both programs, but South Alabama is more likely to buck the trend. Alabama A&M trudged to 286 total yards in losses to UAB and Vanderbilt, so a little bit of defense will go a long way for South Alabama.

Prediction: South Alabama 34, Alabama A&M 10

Tulsa (1-1) at Toledo (2-0), 7 p.m. ET

Do you like scoring? Have we got the game for you. Tulsa hung 66 points on Louisiana, and Toledo is averaging 42 despite almost exclusively running the ball in the fourth quarter so far. Given Tulsa's explosiveness, the Rockets will unleash quarterback Logan Woodside for the first time in 2017. And he'll torch a hapless secondary.

Prediction: Toledo 48, Tulsa 38

Appalachian State (1-1) at Texas State (1-1), 7 p.m. ET

On one side of the ball, Texas State could compete. The defense has accumulated 14 tackles for loss and ceded a meager 1.9 yards per carry over two showings. Unfortunately for the Bobcats, their offense will struggle to put together enough scoring drives to threaten Appalachian State.

Prediction: Appalachian State 33, Texas State 14

Idaho State (1-1) at Nevada (0-2), 7 p.m. ET

Following a pair of losses to quality opponents in Northwestern and Toledo, Nevada should find its way into the win column. It won't happen without a decent fight from Idaho State, but the FCS visitors won't have the firepower to hang around in the second half. Running back Jaxson Kincaide will propel the Wolf Pack.

Prediction: Nevada 37, Idaho State 17

Georgia State (0-1) at No. 5 Penn State (2-0), 7:30 p.m. ET

Georgia State dropped its season opener against Tennessee State of the FCS. Have fun with Saquon Barkley and Penn State! The Nittany Lions should quickly build a multi-possession advantage on the scoreboard and cruise to a third straight win.

Prediction: Penn State 48, Georgia State 7

Samford (2-0) at No. 13 Georgia (2-0), 7:30 p.m. ET

Jacob Eason could return soon, but at Notre Dame the defense showed it's capable of carrying the Dawgs against even above-average competition. Although Samford has a respectable offense, a couple of takeaways will put Georgia on a winning path.

Prediction: Georgia 45, Samford 13

Bowling Green (0-2) at Northwestern (1-1), 7:30 p.m. ET

Northwestern is prone to slow starts, and an ugly loss at Duke only continued the trend. Fortunately for the Wildcats, they can rebound against a Bowling Green team that played poorly at Michigan State and fell to FCS opponent South Dakota.

Prediction: Northwestern 38, Bowling Green 14