A woman's driver's licence has been cancelled by a court after she caused two fatal crashes at the same country intersection.

Pompoota farmer Michelle Leanne Thiele failed to give way at the intersection near Mannum in South Australia in 2000.

That smash killed John Eric Mitchell, 69.

Thiele did the same thing at the same intersection in 2007, killing motorcyclist Graham Bryant, 51.

A coronial inquest found Thiele was an incompetent driver and the Registrar of Motor Vehicles cancelled her licence.

After a series of appeals, the District Court granted her a conditional licence last December.

But the Registrar appealed against that ruling in the SA Supreme Court.

It has now set aside the orders and cancelled Thiele's driver's licence.

Justice Timothy Anderson said there was nothing to stop Thiele from making a fresh application for a learner's permit, but that should be dealt with out of court to avoid more litigation.