A Sydney truck driver arrested yesterday over the alleged shooting death of his own nephew has been charged with murder.

Heavily armed police arrested 47-year-old Abdul Dwikat yesterday following months of investigations into the alleged shooting murder of 23-year-old Siaf Jouda in April.

The Granville man protested his innocence as police from Strike Force Interface arrested him on Byron Street in Yennora.

Abdul Dwikat was arrested on the arrest occurred on Byron Street, Yennora. (9NEWS)

"You've got the wrong person, mate," he told officers.

Mr Jouda was shot three times in the head after he answered the door of his Horsley Park Home on April 23.

He had immigrated to Australia three months earlier, moving from Palestine to be with his fiancée of three years.

Saif Jouda was shot dead at the door of his Horsley Park home. (Supplied)

Mr Jouda's family have been informed the arrest and were still grieving his death, NSW Police Force Superintendent Peter Lennon said.

"They took it in their stride, [they're] still recovering from the death of their relative, but they were most grateful for the investigations that the police have conducted," he said.

Earlier this year, police appealed for information about a truck seen driving near the murder scene.

Police at the scene of the fatal April 23 shooting. (9NEWS) (9NEWS)

Initial investigations suggested the shooter may have parked their vehicle nearby and walked to Mr Jouda's home to commit the murder.

Mr Dwikat was taken to Fairfield Police Station following his arrest and was charged with murder.