D Pletzer received a Cystic Fibrosis Canada postdoctoral fellowship and REW Hancock holds a Canada Research Chair in Health and Genomics and a UBC Killam Professorship. The authors research was supported by grants from the Canadian Institutes for Health Research (CIHR) FDN-154287 and the Cystic Fibrosis (CF) Canada Award Number 2585. The content is solely the responsibility of the authors and does not necessarily represent the official views of the CIHR. The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

No writing assistance was utilized in the production of this manuscript.