Loris Karius will once again be under close scrutiny after a number of mistakes for Liverpool (Getty)

Loris Karius has lost his place in Liverpool’s starting line-up ahead of Wednesday’s trip to Middlesbrough.

The under-fire goalkeeper will be replaced by Simon Mignolet after his mistakes costs points against both Bournemouth and West Ham United.

Aitor Karanka’s men are the Premier League’s lowest scorers and will hope to bounce back from Sunday’s defeat at Southampton.

Kick-off: 7.45pm

Wednesday's Premier League fixtures

Middlesbrough vs Liverpool (7.45pm)

Sunderland vs Chelsea (7.45pm)

West Ham United vs Burnley (7.45pm)

Crystal Palace vs Manchester United (8.00pm)

Manchester City vs Watford (8.00pm)

Stoke City vs Southampton (8.00pm)

Tottenham Hotspur vs Hull City (8.00pm)

West Bromwich Albion vs Swansea City (8.00pm)

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It’s a big game for…

LORIS KARIUS: The German goalkeeper has struggled to keep out of the headlines of late after a number of high profile mistakes and verbal sparring with television pundits. However, here he has the chance to put that business behind him and get Liverpool back to winning ways.

Weird /best stat…

7: Middlesbrough are unbeaten in seven Premier League home matches against Liverpool since a 2-1 defeat in March 2002 (W3, D4).

Remember when…

Liverpool 2 Middlesbrough 2 (14-13 pens) Capital One Cup Third Round 2014

Both teams needed 120 minutes and 28 penalty kicks to separate them but, after Suso dispatched his decisive spot kick for Liverpool, Albert Adomah blazed his effort high and wide to send the Reds through to the fourth round.

Player to watch…

Gaston Ramirez: The Uruguayan is having an impressive season on his return to the Premier League with Boro and could cause a shaky Liverpool defence big problems at the Riverside. His cohesive partnership with Alvaro Negredo gives the home side a real threat going forward.

Past three-meetings…

LIVERPOOL 2 (Rossiter, Fernandez Saez) MIDDLESBROUGH 2 (Reach, Bamford) (14-13 pens), September 2014

MIDDLESBROUGH 2 (Alonso OG, Tuncay Sanli) LIVERPOOL 0, February 2009

LIVERPOOL 2 (Pogatetz OG, Gerrard) MIDDLESBROUGH 1 (Mido), August 2008

Form guide…

MIDDLESBROUGH: LWDLDW

LIVERPOOL: DLWWDW

Vital information…

KICK-OFF TIME: 7:45