Darren Woodson and Tedy Bruschi agree that the Jaguars' defense will have success against the 49ers' offense in Week 16. (0:45)

JACKSONVILLE, Fla. -- The Jacksonville Jaguars will be without leading receiver Marqise Lee for Sunday's game at San Francisco because of an ankle injury.

The team ruled him out on Friday and also listed receiver Allen Hurns (ankle) as questionable.

Lee, who was hurt early in the Jaguars' 45-7 victory over Houston last Sunday, leads the team in receptions (56) and receiving yards (702). This will be the first game he has missed since Week 9 of the 2015 season.

Hurns (36 catches for 446 yards and two TDs) practiced on a limited basis this week for the first time since he suffered a sprained ankle late in the Jaguars' victory over the Los Angeles Chargers on Nov. 12.

Rookies Dede Westbrook, Keelan Cole and Jaydon Mickens helped the Jaguars offset the loss of Hurns. They've combined to catch 44 passes for 705 yards and six touchdowns in the last five games.

The Jaguars (10-4) can clinch the AFC South by beating the 49ers (4-10) or with a Tennessee Titans loss to the Los Angeles Rams earlier in the day.