Four Senate conservatives have announced their opposition to the Senate GOP bill repealing ObamaCare, a power move intended to give them leverage going forward.

Sens. Rand Paul Randal (Rand) Howard PaulRon Paul hospitalized in Texas The Hill's Morning Report - Sponsored by Facebook - Trump previews SCOTUS nominee as 'totally brilliant' Rand Paul says he can't judge 'guilt or innocence' in Breonna Taylor case MORE (R-Ky.), Mike Lee Michael (Mike) Shumway LeeBipartisan representatives demand answers on expired surveillance programs McConnell shores up GOP support for coronavirus package McConnell tries to unify GOP MORE (Utah), Ted Cruz Rafael (Ted) Edward CruzCrenshaw looms large as Democrats look to flip Texas House seat SCOTUS confirmation in the last month of a close election? Ugly The Hill's Morning Report - Sponsored by Facebook - Trump previews SCOTUS nominee as 'totally brilliant' MORE (Texas) and Ron Johnson Ronald (Ron) Harold JohnsonThe Hill's Morning Report - Sponsored by Facebook - Trump previews SCOTUS nominee as 'totally brilliant' The Hill's 12:30 Report: Ginsburg lies in repose CHC leaders urge Senate to oppose Chad Wolf nomination MORE (Wis.) all said they are not ready to vote for the bill in a joint statement.

While the statement was not scathing, it said the current bill would not lower healthcare costs enough to win their support.

“Currently, for a variety of reasons, we are not ready to vote for this bill, but we are open to negotiation and obtaining more information before it is brought to the floor," the statement said.

"There are provisions in this draft that represent an improvement to our current healthcare system but it does not appear this draft as written will accomplish the most important promise that we made to Americans: to repeal Obamacare and lower their healthcare costs.”

The early opposition of Senate conservatives is a blow to the bill but doesn’t mean it’s dead yet, even though Republicans control only 52 seats and can afford no more than two defections and still pass the measure.

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Conservatives want to pressure Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellDemocratic senator to party: 'A little message discipline wouldn't kill us' House to vote on resolution affirming peaceful transition of power Republican lawyers brush off Trump's election comments MORE (R-Ky.) to revise the legislation and move it further to the right.

McConnell is also under pressure from GOP centrists, creating a difficult balancing act for the leader. Each move he makes to one of the two sides risks losing support from the other.

Of the four conservatives, Paul has long been seen as the least likely to end up voting for the bill. The other lawmakers have been seen as more likely to get to "yes,."

Paul, speaking only for himself, said the bill did not repeal enough of Obamacare, pointing to core elements of the GOP bill such as its tax credits and stabilization fund as "new entitlements."

He said now that leadership knows there are not 50 votes for the bill, he hopes a negotiation can begin.

Paul also said it was not clear whether the four senators would stay united as talks continue.

"We have an agreement on the statement, let's see where it goes from there," he said.

Cruz, in a separate statement, emphasized the need to rein in Medicaid spending and lower premiums. He said he was encouraged by parts of the bill, but that more work needed to be done.

Johnson told reporters earlier in the day that he worried the Senate bill would do little to lower premiums, which is a primary goal of many GOP lawmakers.

“I don’t think there’s enough, probably, in there to bring down those premiums, which I think is a problem with both the House and maybe the Senate bill now,” he said.

Peter Sullivan and Nathan Weixel contributed.