A 61-year-old woman has been charged with running over a cyclist and trying to run over four others in horrifying road rage killing in California.

Sandra Marie Wicksted ran over Leslie Ann Pray, 54, as she rode her bicycle in a Claremont neighborhood around 11.30am Sunday morning, according to prosecutors.

Authorities said the impact of the crash sent Pray across a yard and into a driveway where she died.

Sandra Marie Wicksted, 61, has been charged with murder for allegedly running over cyclist, Leslie Pray (pictured), 54, and trying to run over four others in horrifying road rage killing in California

Pray (left) was riding her bicycle in a Claremont neighborhood on Saturday when the incident occurred. Pray's partner of nine years, Betsey Hipple (right), spoke during a vigil on Monday night. 'I cherished her. She was a profoundly gentle soul'

Authorities said the impact of the crash sent Pray across a yard and into a driveway (pictured) where she died

Video courtesy KTLA

Pray was on the bike lane, Wicksted was across the street in another lane. Skids marks from the incident were visible at the scene.

'The fact that the bicyclist was driving northbound on Mills in a bicycle lane, and the vehicle was travelling southbound, with skids we found at the scene shows a direct line right into the bicyclist,' Lt Eric Huizar told ABC 7.

'It's clear to us that she intended to strike the bicyclist.'

Claremont Police Chief Shelley Vander Veen echoed Huizar's conclusion and said their 'investigation shows it was an intentional act and it was completely senseless'.

Four other cyclists told investigators that Wicksted tried to hit them just moments before Pray was killed.

Hundreds attended a vigil on Monday night on Mills Avenue to remember Pray.

Pray's partner of nine years, Betsey Hipple, spoke during the vigil.

'I cherished her. She was a profoundly gentle soul,' she said, according to CBS.

Hundreds (pictured) attended a vigil on Monday night on Mills Avenue to remember Pray

Pray had just rekindled her passion for cycling (pictured is her bike) this summer after 25 years. Wicksted faces one count of murder and four counts of attempted murder. Her bail was set at $2million

'I think I'll have a sadness and carry a big gaping hole in my heart for the rest of my life.'

According to the station, Pray had just rekindled her passion for cycling this summer after 25 years.

Wicksted faces one count of murder and four counts of attempted murder.

If convicted as charged, Wicksted faces a possible maximum sentence of life in state prison.

Wicksted's bail was set at $2million.

The case remains under investigation by the Claremont Police Department.