Emergency crews cover wreckage of a silver Nissan after it was struck by a wrong-way driver on the 403 early Saturday. The driver of another vehicle faces seven charges. (Tony Smyth/CBC) A "horrific scene" opened the long weekend on the roads after police say a truck drove the wrong way on Highway 403 in Burlington, killing an eastbound driver early Saturday.

The Ford F-150 pickup truck was seen going the wrong way on the eastbound 403 near Waterdown Road around 3:30 a.m. Saturday when the truck struck a silver Nissan head-on, killing the 29-year-old Hamilton man who was driving the Nissan, the Ontario Provincial Police said. A 20-year-old Etobicoke woman riding in the Nissan was taken to hospital with serious but non-life-threatening injuries.

Police got a call about the wrong-way driver, and then within one minute received another call about the collision, OPP spokesman Sgt. Kerry Schmidt said

Someone this morning will get a knock on their door, telling them that their loved one will never come home. - Kerry Schmidt, OPP

A transport truck also struck the Nissan and spun it around after the original collision. Police say the man was killed in the first collision, and no one in the transport truck was injured.

The driver of the Ford truck, who was its sole occupant, received minor injuries.

The 35-year-old man from Brampton, Ont., was arrested at scene.

He faces seven charges including impaired driving causing death, impaired driving causing bodily harm, driving while over the legal alcohol limit, dangerous driving and possession of under 30 grams of marijuana.

A woman in the Nissan suffered serious but non-life-threatening injuries. (Tony Smyth/CBC) The highway was closed for six hours Saturday morning for the investigation but has been reopened.

It was "a horrific scene," Schmidt said. "Massive damage to the vehicles. A head-on collision at highway speed is going to result in tremendous damage. There was a lot of glass and debris strewn around the highway."

Schmidt said incidents like this one are why police tell people not to drink and drive.

"This is something that needs to stop," he said. "We don't want to have to knock on anyone else's door. Someone this morning will get a knock on their door, telling them that their loved one will never come home."

The OPP is asking any witnesses who may have seen the Ford prior to the collision to call the investigating officer Tim Schulz at the Burlington OPP detachment at 905-681-2511.