Outspoken, pro-LGBT pop singer Lady Gaga blasted Vice President Mike Pence during a weekend concert after he defended his wife Karen teaching at a Christian school that prohibits "homosexual activity."

During her song "Million Reasons" in Las Vegas on Saturday, the singer stopped and had a few words for Pence that the crowd loved.

"To Mike Pence, who thinks it's acceptable that his wife work at a school that bans LGBTQ, you are wrong," Lady Gaga said while sitting a piano as the audience cheered. "You say we should not discriminate against Christianity; you are the worst representation of what it means to be a Christian. I am a Christian woman, and what I do know about Christianity is that we bear no prejudice, and everybody is welcome. So you can take all that disgrace Mr. Pence, and you can look yourself in the mirror, and you'll find it right there."

The singer — who recently got rave reviews for her acting alongside Bradley Cooper in the remake of "A Star Is Born" — also tore into President Donald Trump over the government shutdown: "If the f***ing president of the United States could please put our government back in business," she said while audience members yelled "f*** Trump." She added that "there are people who live paycheck to paycheck and need their money."

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What did Mike Pence say that got Lady Gaga in a twist?

After Karen Pence was criticized for taking her teaching position at the Christian school, Mike Pence sat down for an interview with EWTN's Lauren Ashburn and decried the attack on Christian education.

"My wife and I have been in the public eye for quite a while but I have to tell you, to see major news organizations attacking Christian education is deeply offensive," Pence said. "We have a rich tradition of Christian education and, frankly, religious education broadly defined. We celebrate it. The freedom of religion is enshrined in the Constitution of the United States. The Constitution prohibits a religious test for holding public office, so we'll let critics roll off out backs."

PREVIEW -- @VP @mike_pence responds to critics of @SecondLady's new job. "The criticism of Christian education in America should stop." Tune in tonight for part one of my full interview with the Vice President on @EWTNNewsNightly at 7 PM EST on @EWTN. pic.twitter.com/YKEHyroswC

— Lauren Ashburn (@LaurenAshburn) January 17, 2019

What was the response to Karen Pence taking her teaching job?

"Why not teach at a school that welcomes everyone, instead of choosing one that won't serve LGBTQ kids, kids of LGBTQ parents?" JoDee Winterhof, senior vice president for policy and political affairs at the Human Rights Campaign, told the Huffington Post in a statement. "The Pences never seem to miss an opportunity to show their public service only extends to some."

GLAAD is circulating a petition titled "Tell Karen Pence and Her School to Stop Discriminating Against LGBTQ Students," and the ACLU tweeted that Karen Pence's decision to teach at the school "sends a terrible message to students. Do we want to live in a country with leaders who are willing to disavow LGBTQ youth?"