If you’re ranking the best quarterbacks in football right now, it’s possible the top two will be facing off this weekend in Kansas City.

Tom Brady has the best resumé and Russell Wilson is on a great roll, but it’s hard to deny Patrick Mahomes is No. 1 on the list. Deshaun Watson has a great case to be right behind him.

Mahomes’ Kansas City Chiefs and Watson’s Houston Texans face off Sunday in what should be the most entertaining game of the day. Most Las Vegas sportsbooks have the over/under for Texans-Chiefs at 55 points, easily the largest total on the board this week. This is going to be an exciting matchup.

All of a sudden there are some questions about the Chiefs. They looked like the first- or second-best team in the NFL before last week, without much argument. Then the Indianapolis Colts came to Kansas City and pushed them around, handing the Chiefs their first loss of the season. Kansas City has a long injury list with some key players, though Tyreek Hill has a chance to return this week from a shoulder injury. Mahomes is banged up, too. He limped around on an ankle injury he aggravated twice against the Colts. The Chiefs won’t be at full strength this week.

The Texans have been hard to predict, but they’re coming off a great game. Watson threw for 426 yards, five touchdowns and no interceptions against an overmatched Atlanta Falcons defense in a 53-32 win last week. It was a perfect 158.3 passer rating. Among starting quarterbacks, Watson ranks second in the NFL in passer rating and Mahomes is third. Wilson leads the league.

Houston is a 4.5-point underdog at Kansas City, and I like the Texans getting those points. The Chiefs have a ton of injuries and it showed last week. The Texans can score a ton, too, thanks to their dynamic quarterback, and I think Watson can at least keep it close. If nothing else, settle in for what should be the best quarterback matchup we’ll see all season.

Houston Texans quarterback Deshaun Watson (4) is coming off a huge game against the Falcons. (Getty Images) More

Here are the Week 6 NFL against-the-spread picks:

SUPERCONTEST

Jaguars (-1.5) over Saints: This feels like a letdown spot for the Saints. They come out of a rough scheduling spot of tough teams or divisional rivals to face a Jaguars team that will be tough to get up for. Remember when it seemed the Saints would be in good shape if they went 3-3 without Drew Brees? Well, they’ve already got the three wins without him. Jalen Ramsey’s status is crucial here though, because he is one of the few cornerbacks who can reasonably cover Michael Thomas.

Falcons (-2.5) over Cardinals: I understand the Falcons aren’t good. Their defense in particular is bad. But the Cardinals are bad, too. Atlanta just has more top-end talent, and I don’t see how the Cardinals slow them down. This could be a surprisingly entertaining game with a ton of points. And if the Falcons lose, I don’t see how coach Dan Quinn has his job by Week 7.

Redskins (-3.5) over Dolphins: Washington is bad. Really bad. But before you take the Dolphins here, remember that Miami has looked like the worst team in the NFL’s modern era through the first quarter of the season.

49ers (+3.5) over Rams: It’s never the best idea to put too much stock into what we just saw. On Monday night, the 49ers looked incredible in blowing out the Browns. Recency bias can be intoxicating. But I’m starting to believe in this 49ers team. They really are sound across the board. This is a fascinating matchup.

Broncos (-2.5) over Titans: Let’s imagine an alternate universe in which the Broncos didn’t get bad roughing-the-passer penalties against the Bears or Jaguars, and they don’t lose on last-second field goals. We’d think a lot differently about a 3-2 Broncos team, right? The loss to the Raiders actually doesn’t look too bad now. A loss at the Packers wasn’t a blowout. Are the Broncos secretly kind of good?

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