The show will air on Labor Day with comedian David Spade as roast master

Comedian Jimmy Carr went as far as to tell Coulter: 'You could kill yourself'

Even Peyton Manning ribbed her, saying she'd won the Kentucky Derby

But Coulter became the butt of most of the day's jokes - and the cruelest

Eight comedians were supposed to take aim at actor Rob Lowe during show

Comedians in charge of ribbing actor Rob Lowe for a Comedy Central show found a new target when Ann Coulter joined the roast's taping on Saturday.

The eight designated comedians and retired quarterback Peyton Manning, did tease Lowe for his 1988 sex tape and some of his failed projects - but saved their most ferocious jokes for Coulter.

English comedian Jimmy Carr went as far as to say during the taping in Los Angeles: 'Ann is one of the most repugnant, hateful, hatchet-face b****es alive.'

He continued: 'It's not too late to change, Ann. You could kill yourself!'

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Ann Coulter joined Comedy Central's roast of actor Rob Lowe on Saturday in Los Angeles (pictured) - but became the butt of many jokes

Comedian David Spade (pictured right with Lowe during the taping) acted as roast master while eight other designated comedians assisted him

Lowe tried to explain why Coulter had been asked to join in the first place and to step on the daises to roast him.

'I think the best daises are daises where you're like, 'what the f***k, he told reporters after the event according to USA Today.

'You need every flavor to make these things go right and cut them all together for a show.'

Comedian David Spade acted as roast master during Saturday's taping, assisted by Manning, Carr, SNL star Pete Davidson, stand-up comedian Nikki Glaser, singer Jewel, Karate Kid actor Ralph Macchio, former Daily Show correspondent Rob Riggle and Comedy Central roasts alum Jeff Ross.

Lowe (pictured during the taping of his own roast Saturday) tried to explain why Coulter had joined in the first place, saying all flavors were needed for the show

Retired quarterback Peyton Manning (pictured) teased Coulter's physical appearance, saying she had recently 'won the Kentucky Derby' - thus implying she looked like a horse

'She seems stiff and conservative, but Ann gets wild in the sheets. Just ask the Klan,' Spade said.

'It looks like she's having a good time. I haven't seen her laugh this hard since Trayvon Martin got shot.'

Manning meanwhile chose to take a jab at Coulter's appearance, implying that she looked like a horse.

'I just realized that I'm not the only athlete up here tonight. As you all know, earlier this year Ann Coulter won the Kentucky Derby,' he said.

In a similar fashion, Davidson wondered: 'If you are here, Ann, who is scaring the crows away from our crops?'

Ross opted for the same brand of humor and said: 'Ann Coulter wants to help Trump make America great again. You can start by wearing a burka. You have a face that would make doves cry.'

He then attacked Coulter, who has never been married, on her sentimental history.

'Ann's against gay marriage. What's your thinking on that? If I can't get a husband they shouldn't, either?' Ross asked.

Singer Jewel (pictured with Lowe) said: 'As a feminist I can't support everything that's been said tonight, but as someone who hates Ann Coulter, I'm delighted'

SNL star Pete Davidson (pictured) wondered: 'If you are here, Ann, who is scaring the crows away from our crops?'

Lowe (pictured left with Spade) suffered jokes about his 1988 sex tape with an unidentified 16-year-old girl and on some of his failed projects - but insisted it was all fair game

Jewel had this to say: 'As a feminist I can't support everything that's been said tonight, but as someone who hates Ann Coulter, I'm delighted.'

The singer also took a jab at Lowe and played her song You Were Meant For Me, pretending to be the unidentified 16-year-old girl in Lowe's sex tape.

'I'm the best thing Rob Lowe was ever in,' the song went.

Coulter meanwhile made no attempt to hide the fact that she was there only to promote her latest book, In Trump We Trust.

She put a copy of it on the lectern while she delivered a few jokes against Lowe, drawing boos from the audience.

Coulter also tried to rib Davidson, but he managed to get more laughs with a sarcastic 'Good one' to the camera, according to the Hollywood Reporter.

The commentator had never seen a celebrity roast, as she told Fox earlier in the evening.

'There is nothing you can tell me to discourage me,' she said. 'My whole career has been an Ann Coulter roast.'

Lowe meanwhile, thought the taping was fair game: 'If you're in the NFL, hit hard. This is the NFL, you're here to hit,' he said.

'There are other places to do soft jokes. If you're on the Comedy Central Roast, you better bring your A-game.'