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At least five people were killed and dozens injured in a horrific pileup including a bus traveling from New York City early Sunday on the Pennsylvania Turnpike, officials said.

The charter bus was heading on a downhill curve around 3:40 a.m. and struck an embankment, causing a crash with several passenger vehicles and three tractor-trailers in Mount Pleasant Township, TribLive reported.

Photos of the wreckage showed a FedEx truck crashed head-on to the side of another vehicle, as well as a charter bus from Ohio Coach Inc. on its side.

The bus company — which runs daily Chinatown service from Canal Street — said the passengers were traveling from New York City to Columbus, Ohio, news station WTAE reported.

Pennsylvania Turnpike spokesman Carl DeFebo said there were five people pronounced dead at the scene, which is around 30 miles east of Pittsburgh.

“About 60 patients have been transported to three area hospitals in Westmoreland County due to multi-vehicle crash,” DeFebo wrote on Twitter.

Excela Frick Hospitals said there were 25 victims, including nine minors, brought for treatment at the medical center. Their conditions are unknown.

Another 18 victims were transported to the University of Pittsburgh Medical Center Somerset Hospital, though 15 have since been treated and released, WTAE reported.

Forbes Regional Hospital received 11 people injured in the crash, including one victim who is in critical condition, TribLive reported.

The turnpike is closed for an 86-mile stretch between New Stanton and Breezewood as authorities investigate.

It’s not clear what caused the accident amid a forecast of light precipitation and temperatures just below freezing.

DeFobo said it was “premature” to determine whether weather played a role in the crash.

Ohio Coach Inc. said it was unable to provide further details about the crash.

“I have no idea what’s going on right now,” a woman reached at the company headquarters told The Post. “[The managers] don’t know either, they are going there to find out now.”

With Post wires