Floyd Mayweather Jr. does not plan on taking another 16-month vacation from the boxing ring, like he did after easily outpointing Shane Mosley in May 2010.

Instead, Mayweather, who knocked out Victor Ortiz on Sept. 17, will make a relatively hasty return: May 5 at the MGM Grand in Las Vegas, adviser Leonard Ellerbe told ESPN.com on Wednesday night.

Mayweather's opponent has not been determined but Ellerbe said, "We're looking to make the biggest fight possible and everyone knows what that fight is, the little fella."

Ellerbe was, of course, referring to Manny Pacquiao. The welterweight champions and the top two pound-for-pound fighters in the world have been on a collision course for years. However, negotiations have fallen apart over drug testing protocol.

Pacquiao is set to fight Juan Manuel Marquez for the third time Nov. 12 at the MGM Grand and is a heavy favorite.

"Floyd made it very clear that he wants to give the fans the biggest fights that are out there. He wants to stay active," Ellerbe said. "We're going to do everything in our power to make the biggest fight out there for the fans and we all know what the fight is."

Mayweather, a five-division champion, has fought only five times since 2007.

Ellerbe said Mayweather informed him and fellow adviser Al Haymon on Wednesday of his decision to return in May.

"We had a discussion, Floyd, me and Al," Ellerbe said. "Floyd made it very clear to us what he wanted to do. He told us he is looking to make the biggest fight that is out there and to make it in May."

Ellerbe also informed Golden Boy promoter Richard Schaefer, who does not have a contract with Mayweather but has promoted his last five bouts, of the plan.