Weapon breaking/degradation. I thought I wasn't gonna touch the subject of weapon degradation from the game, since it has been one of the most talked subjects in the community. Some people love the mechanic, others hate it. Since enemies can become stronger per area or based on the gear you are wearing, having a 4 DMG Axe won't do much against a Lynel. There is no weapon too cool or too unique to lose and not be able to get it again by simply playing the game. Consider this: it's way more fun to try different weapons with different enemies and learn how what works best depending on your strategy.

Strategy. This is one of the substantial changes, reflected by a mix of game design and mechanics. Everyone will approach the game differently, because there is no unique way to play the game. One of the points that will make this game timeless.

Slow motion. Who doesn't like slow motion, seriously?

Mini bosses. Did you get bored trying to collect fifteen Energetic Rhyno Bettles? Or 55 Rushrooms for only a single diamond? No problem. Now there are mini bosses all across the map for when you want a change of pace. And get some good materials to upgrade your items or sell, too.

Gear & Great Fairies. Upgrading gear is just another positive addition to enhance the sense of progression. The mechanic of Buffs provided by upgraded gear is a welcome new feature.

The Legend of Kass. "I happen to know a song about the ancient hero. It was passed down by my teacher. Do you care to hear it?" -Kass. What Kass didn't tell you is that he is the true legend of this game.

No Magic Bar. Having a magic bar was annoying, and now every other Zelda game with it will feel obsolete. Bomb flowers were cool, but infinite cube bombs are cooler.