A frat war involving students at St. John’s University led to four arrests Wednesday, when up to 20 men from one disgraced fraternity broke into the Queens home of another and started brawling, police and law-enforcement sources said.

The battle between members of Tau Kappa Epsilon (TKE) and Kappa Sigma started with the 4:15 a.m. break-in at an unofficial Kappa Sigma one-family home at 69-20 178th St. in Flushing, said cops and a source with knowledge of the situation.

Two people were punched in the face as thugs from TKE stole a pair of Greek letters and ransacked the place, causing damage of more than $250 before fleeing in three cars, according to sources and police.

“They showed up … and broke the door in, trashed the house. They had baseball bats,” said one of the attacked home’s residents, Vincent Razzano, 20, a junior. “This wasn’t just a joke. It wasn’t a prank.”

Another resident of the house, 19-year-old Jeremy Thomas, said: “They were TKE, about 20 of them with bats. They took our Kappa. There were only a couple of us here.

“They threw my fridge out and trashed my living room.”

Suspects Anthony Vithayathil, 19, Brandon Wong, 19, Sebastian Willams, 22, and Nicholas Crocco, 19, were arrested shortly after and all charged with burglary and criminal mischief, police said.

Authorities said they are still looking for the other frat brothers involved in the incident.

Cops were called to the residence – which is about a mile away from St. John’s University – for a “home-invasion” involving between 13 and 20 men, sources said.

The drama leading up to the break-in was sparked the night before by a bar fight at nearby Parsons Ale House that escalated throughout the night, cops and witnesses said.

“There was a dispute last night at a bar, some people talking sh–t. It spilled over into the street, and then they came here,” Thomas said.

According to police, both fraternities involved previously lost their charters and standing on campus. The victims and the suspects are St. John’s students.

The victims, authorities said, knew at least some of the perps and gave their names up to police.

“Last night, I heard people came into my house and stole some sh–t,” said Amir Kerrar, 20, a junior who is among six men who live at the attacked home, where beers cans filled several black garbage bags outside, red Solo cups littered the lawn, and two couches were piled on the small front porch.

Kerrar, who had to move a beer keg out of the way to answer the door, said he and his pals moved into the home two months ago and insisted, “We’re not a frat, just college students.

“A couple of juniors, a couple of sophomores, a couple of freshman,” Kerrar said.

The economics major added: “People were arrested who didn’t live here.”

Not all of the students who live at 69-20 178th St. are part of a fraternity, a source said.

Neighbors say rowdy activity is a common occurrence at the home near 69th Avenue.

“They are totally out of control,” said Jose Chan, a married optometrist with two young children who lives across the street. “It’s like a nightclub! Always people rolling up at all hours, 50 people, sometimes 100 people. It’s bad!”

Chan said that when the students moved in over the summer “I had to log a 311 complaint.

“The noise, the coming and going, they love to hang out front. I don’t get it, look at that lawn!” he said. “A lot of nights they hang out in their front yard and spill over into other people’s yards.”

Another neighbor, Edward Pan, said there were up to 50 people at the house Tuesday night.

“The parties are outside. They are always out front drinking beers with the music loud,” Pan said. “They party every week. …They never clean up.”

St. John’s University spokesman Brian Browne said in a statement: “We are concerned about the report that several of our students were involved in an off-campus incident between two non-sanctioned fraternities. The University is cooperating with law enforcement and the students involved will be subject to disciplinary action under the University’s code of conduct.”

The Roman Catholic college does not have official fraternity housing on or off campus.