A collection of reptiles has been stolen from a wildlife reserve on the New South Wales' mid-north coast.

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Kotara's Blackbutt Reserve said their entire reptile collection was stolen during a break-in overnight.

Among the reptiles stolen were a spotted python, an olive python, shingle back lizards and frilled-neck lizards.

The City of Newcastle posted on social media asking for anyone with information to call police.

Some locals took to Facebook to suggest their reptiles could be borrowed by the reserve for the exhibits.

The wildlife reserve, located in Newcastle, said the daily reptile show was now cancelled until further notice.