WASHINGTON—A senior Islamic State leader was killed, and his wife captured, in a raid in eastern Syria by U.S. Special Operations forces, the first on-the-ground mission in that country targeting wanted extremists, defense officials said on Saturday

The operation was conducted at Al-Amr, in the eastern region of Syria, to capture Abu Sayyaf and his wife, Umm Sayyaf, also thought to be part of the organization, Pentagon officials said.

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