WASHINGTON (AP) — The Latest on the 2016 presidential campaign (all times Eastern Daylight Time):

5:10 p.m.

Donald Trump says President Barack Obama should resign because he "refused to even say the words 'radical Islam'" in his response to the Orlando shooting.

And he says Democrat Hillary Clinton should exit the presidential race if she takes the same approach.

The presumptive Republican nominee made his comments in a statement issued in response to the attack on a Florida gay nightclub, which left at least 50 dead and scores more wounded.

Trump has proposed temporarily barring foreign Muslims from entering the country to protect against potential threats.

The suspect in the early Sunday shooting has been identified as an American citizen whose family was from Afghanistan.

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4:15 p.m.

Hillary Clinton's presidential campaign is postponing its first joint event with President Barack Obama on Wednesday in Green Bay, Wisconsin, because of the deadly shooting in Orlando, Florida.

Clinton's campaign says Sunday the event will be rescheduled in light of the Florida shooting. The White House confirmed the cancellation.

Clinton and Obama were scheduled to make their first appearance together since the president announced his endorsement of the likely Democratic nominee last week.

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4:05 p.m.

Hillary Clinton says the mass shooting at an Orlando nightclub is "an act of terror" and urges the nation to redouble its efforts "to defend our country from threats at home and abroad."

The presumptive Democratic presidential nominee says the deadliest shooting in U.S. history is "also an act of hate," noting that the gunman attacked a gay nightclub during June, when gays and lesbians celebrate Pride Month.

Clinton says the U.S. needs to take more steps to keep guns like the ones used in the shooting "out of the hands of terrorists or other violent criminals.

Clinton's Democratic rival, Bernie Sanders, says Americans are horrified by the shooting but at this point we don't know if it was an "act of terrorism, a terrible hate crime against gay people or the act of a very sick person."

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2:00 p.m.

Donald Trump isn't pausing his political commentary for the biggest mass shooting in U.S. history unfolding in Florida.

It was unclear whether the shooter who killed at least 50 people in an Orlando, Florida nightclub was associated with a radical religious organization. President Barack Obama addressed the nation, calling the shooting "an act of terror" and an "act of hate."

Trump tweeted as Obama began speaking: "Is President Obama going to finally mention the words radical Islamic terrorism? If he doesn't he should immediately resign in disgrace!"

A law enforcement official tells The Associated Press that the shooter was known to the FBI before the incident. The official was not authorized to discuss the ongoing investigation and spoke on condition of anonymity.

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10:15 a.m.

Donald Trump's top supporter in the Senate says it was a "rough week" for the presumptive Republican presidential nominee because it got the candidate off message.

Trump was hounded by Republicans and Democrats for saying a federal judge overseeing a Trump-related case might be biased against Trump because of the judge's Mexican heritage.

Sen. Jeff Sessions — in an interview with "Fox News Sunday" — calls it "one off-the-cuff comment that he probably shouldn't have made."

The Alabama lawmaker says he expects Trump to refocus on the need for change. Sessions says "this man communicates. He's talking about the issues people care about."

Sessions says those issues include unfair imports and excessive immigration that takes jobs away from Americans and pulls wages down.

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10:08 a.m.

Hillary Clinton's campaign is out with its first general election ad.

The ad splices clips of Donald Trump threatening protesters and mocking a disabled reporter with scenes of Clinton visiting factories, greeting diverse groups of voters and stepping off a plane as secretary of state.

She ends the one-minute spot saying: "What kind of America do we want to be? Dangerously divided or strong and united? I believe we are always stronger together."

Trump has been quick to respond. On Twitter, he wrote: "Clinton made a false ad about me where I was imitating a reporter GROVELING after he changed his story. I would NEVER mock disabled. Shame!"