Massachusetts Sen. Elizabeth Warren’s vow to battle President-elect Donald Trump “and his team of billionaires, bigots and Wall Street bankers” as she announced her re-election plans yesterday could trigger the vengeful Manhattan mogul’s wrath in an ugly 2018 Bay State Senate race.

“(There’s) an added incentive for the Trump administration, knowing how vehemently she worked against his election,” said state Rep. Geoff Diehl, who co-chaired the president-elect’s Bay State campaign. “I’d expect him to get involved.”

Warren blasted Trump on Twitter and at press conferences throughout the 2016 presidential campaign, and is hoping to ride a likely anti-Trump backlash in Massachusetts all the way back to Washington in 2018.

But the brash billionaire has a long memory, almost always hits back and can be intensely motivated by vengeance. Some of Trump’s closest supporters believe he decided to run for the White House after President Obama unrelentingly roasted him at the White House Correspondents’ Dinner in 2011.

With Democrats already forced to defend 25 of the 33 open Senate seats in 2018 (including two independents who caucus with the Dems), Trump could make it his personal mission to take out the insult-hurling Warren at the polls.

Warren officially announced she’s running for re-election, putting Republicans on notice to field their own challenger.

“(The) people of Massachusetts didn’t send me to Washington to roll over and play dead while Donald Trump and his team of billionaires, bigots, and Wall Street bankers crush the working people of our Commonwealth and this country,” she wrote. “This is no time to quit.”

So far, the only possible big-name candidate is former Red Sox ace Curt Schilling, but more may surface in the next few months.

“There are several people who are legitimately looking at it,” said Massachusetts Republican National Committeeman Ron Kaufman, who declined to name them because he said he had been asked not to.

“I think she’ll have a challenge from within the party and a challenge from our side. I think it’ll be a spirited race,” he said.

Schilling, who has said he’s considering a run, yesterday tweeted, “If I run we will kick her (expletive). Book it.”

But he declined a request for a formal interview. “She seems to be doing all right ruining herself every time she opens her mouth,” he told the Herald. “No need for me to help.”

Former Massachusetts Gov. William F. Weld, who ran for vice president last year on a ticket with Libertarian nominee Gary Johnson, ruled out a 2018 Senate run yesterday.

“Not interested,” Weld wrote in an e-mail to the Herald asking if he planned to challenge Warren.

Both Diehl and former state Rep. and Judge Dan Winslow said they haven’t ruled out runs themselves.

The early Republican playbook seems to be to cast Warren as too liberal even for Massachusetts.

“Whoever ends up running, … they will all be to the center of Warren,” said Kaufman. “Michael Dukakis would be to the center of Elizabeth Warren.”