A doctor has been shot dead by an intruder at his home in Brisbane's south overnight.

General practitioner Luping Zeng, 56, was shot in the chest following a confrontation with an intruder in the garage at his Delfin Drive home in MacGregor about 11.40pm on Monday.

Detectives assured residents of the MacGregor street they were safe, despite a well-planned burglary three months ago two houses down from the scene of Monday's shooting.

Dr Zeng worked at the Waterford Seven Day Medical Centre and Skin Cancer Clinic as a GP with specialised skin cancer training.