Abstract

Background Memory deficit is a co-morbid disorder in patients suffering from neuropathic pain. Gabapentin and pregabalin (gabapentinoids) are among the widely prescribed medications for the treatment of neuropathic pain. Memory loss and sedation are the commonly reported side effects with gabapentinoids. Improving the cognitive functions and attenuating drug-induced side effects may play a crucial role in the management of pain.

Methods We evaluated the effects of 5-HT 6 receptor antagonists on the memory deficits associated with neuropathy. We also studied the effects of 5-HT 6 receptor antagonists on the side effects, and the analgesic effects of gabapentinoids.

Results 5-HT 6 receptor antagonists attenuated the cognitive deficits in neuropathic rats. Neuropathic rats co-treated with 5-HT 6 receptor antagonist and gabapentinoids showed improvement in memory. 5-HT 6 receptor antagonists enhanced the analgesic effects of gabapentinoids but had no effect on the motor side effects. The observed effects may not be due to pharmacokinetic interactions.