Hillary Clinton Hillary Diane Rodham ClintonButtigieg stands in as Pence for Harris's debate practice Senate GOP sees early Supreme Court vote as political booster shot Poll: 51 percent of voters want to abolish the electoral college MORE on Tuesday called San Francisco Mayor Ed Lee’s death a “terrible loss” for the city.

Mayor Ed Lee’s death is a terrible loss for the people of San Francisco. He was a good friend & a vocal advocate for the city he served & loved. My thoughts are with his family. — Hillary Clinton (@HillaryClinton) December 12, 2017

Lee died Tuesday at the age of 65 after suffering a heart attack.

Lee became mayor when his predecessor, Gavin Newsom, left to become the state’s lieutenant governor in January 2011. He won a full term that November, and was reelected in 2015.

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London Breed, the president of the city’s Board of Supervisors, will now serve as acting mayor.

Sen. Kamala Harris Kamala HarrisButtigieg stands in as Pence for Harris's debate practice First presidential debate to cover coronavirus, Supreme Court Harris joins women's voter mobilization event also featuring Pelosi, Gloria Steinem, Jane Fonda MORE (D-Calif.) praised Lee as “an outspoken advocate for diversity and inclusion.”

Sen. Dianne Feinstein Dianne Emiel FeinsteinBiden leads Trump by 12 points among Catholic voters: poll Names to watch as Trump picks Ginsburg replacement on Supreme Court McConnell says Trump nominee to replace Ginsburg will get Senate vote MORE (D-Calif.) called Lee’s death a “sad day for San Francisco and all of us who knew him.”