No team was happier to see David Ortiz walk away than the Toronto Blue Jays.

The man known as Big Papi hit more homers (62) and drove in more runs (192) against the Blue Jays in his amazing career than he did against any other ballclub, a resume that’s enhanced even further by 41 round-trippers at the Rogers Centre alone.

While Jays arms will be relieved to know they won’t have to deal with Ortiz when they battle the Boston Red Sox 19 times this season, he wasn’t the only Blue Jays’ nemesis.

Here are 10 active Jays killers to keep an eye on this season:

10. RHP Jake Odorizzi, Tampa Bay Rays: .203 average against

Of all the American League East pitchers who could give the Jays trouble, Odorizzi has been the stingiest, holding Toronto bats to a paltry .203 batting average over 66.1 innings. It hasn’t been perfect — he’s given up nine home runs — but the 27-year-old righty has posted a solid 3.26 ERA against the birds in blue, better than his 3.75 career mark. His teammate, centre fielder Kevin Kiermaier, has also experienced a bunch of success against the Jays early in his career, with the second-best active career average against Toronto (.335) and an .877 OPS (on-base plus slugging) in 175 plate appearances.

9. 1B Eric Hosmer, Kansas City Royals: .331 batting average

Twelve active players have .300 or better career averages when facing the Blue Jays, and Hosmer sits third on that list behind only Kiermaier and a name you’ll find closer to the top of this list in Albert Pujols (.340). In 160 at-bats, the Royals’ 27-year-old first sacker has touched grass 53 times, with 12 of those hits going for extra bases.

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8. 3B Manny Machado, Baltimore Orioles: .904 OPS

One of the premier talents in the game today, Machado, like most of the names on this list, is a thorn in everyone’s side. Machado’s .904 OPS against the Jays places him eighth amongst active players, and he’s nowhere near the prime of his career yet as he approaches the age of 25. Machado is going to be peppering major league pitching for a long, long time.

7. OF Mike Trout, Los Angeles Angels: .940 OPS

Take everything written about Machado, amplify it a little bit, sprinkle in a couple of MVP awards, and look to the outfield instead of the hot corner. That’s where you’ll find Trout, undeniably the best player in all of baseball right now. Luckily for the Blue Jays, Trout resides out in California instead of the AL East, so they don’t have to deal with the ridiculous .940-career OPS he’s posted against their pitching as often as they would if he played in the division.

6. RHP Masahiro Tanaka, New York Yankees: 2.34 ERA

The owner of a 3.12 ERA in his three MLB seasons, you knew Tanaka was going to have excellent numbers against his AL East rivals. In fact, Tanaka’s 2.34 ERA in 10 career starts versus the Jays is the second best active mark in all of baseball, behind only Matt Garza’s surprising 2.14 ERA against the Jays.

5. 1B Carlos Santana, Cleveland Indians: .942 OPS

This isn’t the 1B/DH that Jays fans will be paying attention to when the Indians are on the schedule this season — that’ll be some guy trotting around with a parrot on his shoulder — but the pitching staff would be wise to bold his name. Santana’s career OPS against Toronto is a gaudy .942 on the strength of reaching base at an amazing .445 clip, far and away the best active mark off Jays’ pitching in 200 plate appearances.

4. LHP David Price, Boston Red Sox: 17-3, 2.42 ERA

It may not matter much if his suddenly balky left elbow doesn’t cooperate this season, but Price has been lights out against the Jays in his career, running up the most active wins (17) and a minuscule 2.42 ERA over eight seasons. Only three active pitchers have a sub-3.00 ERA against the Jays.

3. 1B Albert Pujols, Los Angeles Angels: .340 batting average

Similar to Machado and Trout, Pujols has been laying a beating on just about every team over his career, the only difference being this sure-fire Hall of Famer is already on the back nine. Pujols only arrived in the American League in 2012, but thanks to a sprinkling of Interleague at-bats, the 37-year-old has the highest active average against the Blue Jays at .340 and the sixth-best OPS at .915.

2. OF Nelson Cruz, Seattle Mariners: .946 OPS

We’re starting to get into some monster OPS numbers in this area of the list, and Cruz’s .946 mark is one of the biggest, sitting just behind Los Angeles Dodgers first baseman Adrian Gonzalez’s .968 OPS for the second-best active mark against Toronto. Nellie has sunk the Jays with the longball, crushing 21 homers in 77 games to help him to a .585 slugging percentage. The 36-year-old is aging like a fine wine, too, surpassing 40 homers, overall, in each of the past three seasons.

1. 1B Chris Davis, Baltimore Orioles: 1.017 OPS

As a 31-year-old who’s a decade into his major league career, the book on Davis is out. When he connects, it’s going a long way. That’s if he connects. But connecting is something Davis has done with regularity in 447-career trips to the plate against the Blue Jays, as he’s absolutely destroyed just about everything Toronto arms have thrown at him, running up a 1.017 OPS that includes 35 home runs, the most of any player. Over his career, Davis has slashed .250/.330/.499, but those numbers jump to .287/.383/.634 when he’s facing the Blue Jays.

smitchell@postmedia.com