WASHINGTON -- An hour after his team finished a dominating defensive performance to close in on the Final Four, Syracuse coach Jim Boeheim stood in a hallway and talked on and on about his trademark 2-3 zone.

Proud as can be. And rightly so.

"You have to know what to do against it," Boeheim said.

Indiana most certainly did not.

Limiting the No. 1-seeded Hoosiers to their lowest output of the season while forcing 19 turnovers and blocking 10 shots, fourth-seeded Syracuse used Michael Carter-Williams' 24 points to upset Indiana 61-50 on Thursday night and reach the East Regional final.

"Our perimeter defense was tremendous," Boeheim said, his arms crossed across his purple tie, the way he stood for much of the lopsided game. "This is one of our best defensive teams ever. They play it well."

The last time these two schools faced off in the NCAA tournament, Indiana won on a late shot -- and it took winning a national title for Boeheim to get over it. This meeting, 26 years later, was never close enough to come down to the final seconds.

After getting past preseason No. 1 Indiana, Syracuse (29-9) will face No. 3 seed Marquette on Saturday night in an all-Big East matchup, assuring the soon-to-be-reconfigured conference a berth in the Final Four. Boeheim and the Orange haven't been to the national semifinals since Carmelo Anthony led them to the 2003 championship.

Marquette beat No. 2 seed Miami 71-61 in Thursday's first game in Washington.

Syracuse, which is leaving for the Atlantic Coast Conference this summer, lost at Marquette 74-71 during the Big East regular season on Feb. 25.

"We're much better when we play teams that don't know us," Boeheim said. "Marquette knows us. They know how to play against us, so it will be very difficult."

Less than a half-minute into Thursday's game, as Indiana star Victor Oladipo headed to the free throw line, the arena's overhead scoreboard showed a replay of "The Shot," as it's come to be known -- Keith Smart's baseline jumper in the final seconds that lifted Bob Knight's Hoosiers past Boeheim's Orange in the 1987 national title game.

Boeheim said he wasn't able to put that behind him until 16 years later, when he got his title. Boeheim entered Thursday with 50 wins in the tournament, fourth-most in history, and more than 900 victories overall, with so much of that success built on his unusual zone defense, 40 minutes of a puzzle for opponents to try and solve.

Indiana (29-7), like most teams outside the Big East, isn't used to seeing that sort of thing, and it showed right from the outset. Didn't matter that Indiana ranked third in the country this season in scoring, putting up 79.5 points per game -- and never fewer than 56 -- while making 48.6 percent of its shots.