Multidimensional studies





Myalgic Encephalomyelitis/Chronic Fatigue Syndrome at the National Institutes of Health



National Institute of Neurological Disorders and Stroke (NINDS)

Study Start Date: January 21, 2016

Estimated Study Completion Date: September 15, 2020

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Dr Avindra Nath presenting the study (video)

Lead researcher: Avindra NathNational Institute of Neurological Disorders and Stroke (NINDS)Study Start Date: January 21, 2016Estimated Study Completion Date: September 15, 2020

ME/CFS Severely ill Big Data Study



More information Open Medicine Foundation





NIH ME/CFS centers:



*Cornell ME/CFS Collaborative Research Center



Cornell University, Ithaca, New York

Center registration

More information Lead researcher: Maureen Hanson, Ph.D.Cornell University, Ithaca, New York

Main research projects:

- Brain imaging study, led by Dikoma Shungu (See the neurology studies list below for more information)

- Extracellular vesicles, led by Hanson (See the immunology studies list below for more information)

- RNAs in white blood cells, led by Andrew Grimson (See the genetic studies list below for more information)



* Center for Solutions for ME/CFS



Columbia University, New York City

Center registration

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Lead researcher: W. Ian Lipkin, M.D.Columbia University, New York City

*Topological Mapping of Immune, Metabolomic and Clinical Phenotypes to Reveal ME/CFS Disease Mechanisms



The Jackson Laboratory, Farmington, Connecticut

Center registration

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Lead researcher: Derya Unutmaz, M.D.The Jackson Laboratory, Farmington, Connecticut

*Data Management and Coordinating Center (DMCC) for the ME/CFS Collaborative Research Centers



Research Triangle Institute, Research Triangle, North Carolina

Center registration





ME/CFS Collaborative Research Center at Stanford Lead researcher: Rick L. Williams, Ph.D.Research Triangle Institute, Research Triangle, North Carolina



Research projects:

T cells and the molecular immunology of ME/CFS

Extended big data study in families

Developing blood-based diagnostic and drug screening technology

More information

S4ME thread



Immunology Lead researcher: Ronald W. DavisResearch projects:T cells and the molecular immunology of ME/CFSExtended big data study in familiesDeveloping blood-based diagnostic and drug screening technology

Immune System Dysfunction



ME Association Ramsay Research Fund / Action for ME

Start: 2014

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Lead researchers: Professor Stephen Todryk and Professor Julia NewtonME Association Ramsay Research Fund / Action for MEStart: 2014

Cyclophosphamide in Myalgic Encephalopathy/ Chronic Fatigue Syndrome (ME/CFS) (CycloME) Treatment study



Haukeland University Hospital

Start: 2015

Estimated Study Completion Date: January 2017

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Lead researchers: Mella Olav, Øystein FlugeHaukeland University HospitalStart: 2015Estimated Study Completion Date: January 2017

The role of autoantibodies in ME/CFS



Institute of Medical Immunology, Charité University Medicine Berlin, Berlin, Germany

MERUK

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Lead researchers: Dr Madlen Löbel & Prof. Carmen ScheibenbogenInstitute of Medical Immunology, Charité University Medicine Berlin, Berlin, GermanyMERUK

An immunosignature assay for rituximab therapy?



School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, USA

MERUK

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Lead researcher: Prof. David PatrickSchool of Population and Public Health, University of British Columbia, Vancouver, British Columbia, USAMERUK

Lymphocyte phenotype and cytokine production in ME/CFS patients and patients treated with chemotherapy for breast cancer



Leeds NHS Teaching Hospital NHS Trust, St James’s University Hospital, Leeds

MERUK

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Lead researchers: Dr Clive Carter, Dr Philip Wood and colleaguesLeeds NHS Teaching Hospital NHS Trust, St James’s University Hospital, LeedsMERUK

Ampligen in Chronic Fatigue Syndrome Treatment study



Study Start Date: March 1997

Estimated Study Completion Date: February 2019

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S4ME thread

HemispherxStudy Start Date: March 1997Estimated Study Completion Date: February 2019

Extracellular vesicles



Cornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center

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Lead researcher: Maureen HansonCornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center

Combatting oxidative stress



Vascular & Inflammatory Diseases Research Unit, Division of Cardiovascular & Diabetes Medicine and Division of Cancer Research, Ninewells Hospital & Medical School, Dundee, UK

MERUK

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Lead researchers: Dr Faisel Khan, Prof JD Hayes, Prof J Belch, et al.Vascular & Inflammatory Diseases Research Unit, Division of Cardiovascular & Diabetes Medicine and Division of Cancer Research, Ninewells Hospital & Medical School, Dundee, UKMERUK

Immunoadsorption in patients with autoantibodies to ß adrenergic receptors Treatment study



Charité, Berlin, Germany

Fresenius Medical Care

More information (German)

Lead researcher: Carmen ScheibenbogenCharité, Berlin, GermanyFresenius Medical Care

HyQvia in patients with immunoglobulin deficiency, frequent infections and CFS Treatment study



Baxalta

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Information on HyQvia



Chronic fatigue syndrome: Leptin, interleukin 6 and clinical symptoms

Lead researcher: Michael Musker

South Australian Health And Medical Research Institute (SAHMRI), Australia

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Charité, Berlin, GermanyBaxaltaLead researcher: Michael MuskerSouth Australian Health And Medical Research Institute (SAHMRI), Australia

Immuno-senescence and cell-cycle analysis in the pathophysiology of ME/CFS



Washington University (USA), Cambridge University (UK)

SMCI

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Biomarkers for initiation (infection) and metabolic derangement in ME/CFS

Lead researchers: Drs. Blomberg, Bergquist, Gottfries, and Zachrisson

Gottfries clinic, Mölndal, Uppsala University Hospital (Sweden)

SMCI, Ramsay Award Program (2017)

Start: 2018 Lead researchers: Dr. Sheila Stewart, Dr. Masashi NaritaWashington University (USA), Cambridge University (UK)SMCILead researchers: Drs. Blomberg, Bergquist, Gottfries, and ZachrissonGottfries clinic, Mölndal, Uppsala University Hospital (Sweden)SMCI, Ramsay Award Program (2017)Start: 2018

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Immunometabolism of T cells and monocytes in ME/CFS

Lead researchers: Drs. Carmen Scheibenbogen and Franziska Sotzny

Charité – Universitätsmedizin Berlin (Germany)

SMCI, Ramsay Award Program (2017)

Start: 2018

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Metabolic Analysis of B Cell Maturation

Lead researchers: Chris Armstrong, Fane Mensah and Professor Jo Cambridge



SMCI, Ramsay Award Program (2016)

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SMCI presentation Melbourne Bioanalytics (Australia), University College London (UK)SMCI, Ramsay Award Program (2016)



Metabolic Assessment of Natural Killer Cells

Lead researchers: Drs. Isabel Barao-Silvestre, Ruben Dagda, and Victor Darley-Usmar

University of Nevada Reno, University of Alabama, Birmingham (USA)

SMCI, Ramsay Award Program (2016)

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Identifying Autoimmune signatures in ME/CFS

Lead researchers: Dr. Carmen Scheibenbogen and Madlen Lobel

Charité University Medicine Berlin, Charité Universitatsmedizin Berlin (Germany)

SMCI, Ramsay Award Program (2016)

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The potential role of HHV-6 in ME/CFS

Lead researcher: Bhupesh Prusty

Julius Maximilian University of Wurzburg (Germany)

SMCI, Ramsay Award Program (2016)

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Investigation of human endogenous retrovirus expression in individuals with myalgic encephalomyelitis

Lead researcher: Dr Camila Malto Romano

USP - Universidade de São Paulo (Brazil)

Using UK ME CFS Biobank

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Droplet digital PCR for evaluation of associations between human Herpes virus infection and Myalgic encephalomyelitis/chronic fatigue syndrome(ME/CFS)

Lead researchers: Eleanor Riley, Jackie Cliff

London Sch/Hygiene & Tropical Medicine

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A longitudinal immunological and virological study for ME CFS biomarker discovery

Lead researcher: Luis Nacul

London Sch/Hygiene & Tropical Medicine

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Defining autoimmune aspects of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

PhD research: Katharine Seton

Invest in ME

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Drs. Carmen Scheibenbogen and Franziska SotznyCharité – Universitätsmedizin Berlin (Germany)Lead researchers: Chris Armstrong, Fane Mensah and Professor Jo CambridgeLead researchers: Drs. Isabel Barao-Silvestre, Ruben Dagda, and Victor Darley-UsmarUniversity of Nevada Reno, University of Alabama, Birmingham (USA)SMCI, Ramsay Award Program (2016)Dr. Carmen Scheibenbogen and Madlen LobelCharité University Medicine Berlin, Charité Universitatsmedizin Berlin (Germany)SMCI, Ramsay Award Program (2016)Bhupesh PrustyJulius Maximilian University of Wurzburg (Germany)SMCI, Ramsay Award Program (2016)Lead researcher: Dr Camila Malto RomanoUSP - Universidade de São Paulo (Brazil)Using UK ME CFS BiobankLead researchers: Eleanor Riley, Jackie CliffLondon Sch/Hygiene & Tropical MedicineLead researcher: Luis NaculLondon Sch/Hygiene & Tropical MedicinePhD research: Katharine SetonInvest in ME

Energy metabolism



Examining Mitochondria in ME/CFS

Lead researcher: Dr Karl Morten

ME Association Ramsay Research Fund

Using UK Biobank samples

Start: 2017

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S4ME thread

Lead researcher: Dr Karl MortenME Association Ramsay Research FundUsing UK Biobank samplesStart: 2017

Comparison of results from a commercial and NHS blood test to assess mitochondrial function



ME Association Ramsay Research Fund

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Lead researcher: Dr Sarah Jayne BoultonME Association Ramsay Research Fund

Abnormalities in Mitochondrial Function in Skeletal Muscle



ME Association Ramsay Research Fund/Medical Research Council

Preliminary results (2015)

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Bioenergetics capacity, ATP production and potential drug targets using advanced technologies

Lead researcher: Dr. Ralph Garippa

Memorial Sloan Kettering Cancer Center (MSKCC), New York City (USA)

SMCI

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Lead researcher: Professor Anne McArdleME Association Ramsay Research Fund/Medical Research CouncilLead researcher: Dr. Ralph GarippaMemorial Sloan Kettering Cancer Center (MSKCC), New York City (USA)SMCI

Projects

Longitudinal metabolic and genomic study



Melbourne Bioanalytics, Australia

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Mitochondrial Respiratory Function and Cellular Metabolism in Lymphoblasts

Lead researcher: Chris Armstrong, Daniel Missailidis and Paul Fisher

Melbourne Bioanalytics, LaTrobe University, Australia

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Lead researcher: Chris ArmstrongMelbourne Bioanalytics, Australia

Muscles studies

Investigating abnormalities in AMPK activation



Lead researcher: Dr Audrey Brown

Institute of Cellular Medicine, Newcastle University, Newcastle, UK

MERUK

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Lead researcher: Dr Audrey BrownInstitute of Cellular Medicine, Newcastle University, Newcastle, UKMERUK

Muscle metabolites in patients before and after exercise



University of Washington

SMCI, Cathleen J. Gleeson PhD Fund

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Lead researchers: Pr. Kevin Conley, Pr. David MaughanUniversity of WashingtonSMCI, Cathleen J. Gleeson PhD Fund

Neurology studies

Neurological biomarkers in paediatric ME/CFS



Murdoch Children’s Research Institute, The Royal Children’s Hospital, University of Melbourne, Melbourne, Australia

MERUK

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Lead researcher: Dr Sarah Knight and colleaguesMurdoch Children’s Research Institute, The Royal Children’s Hospital, University of Melbourne, Melbourne, AustraliaMERUK

Markers of neuroinflammation and oxidative stress



Cornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center

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Lead researcher: Dikoma ShunguCornell Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Center

Interrogating the brain: experiments with laser-evoked potentials and cerebral blood flow



Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium

MERUK

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Lead researchers: Prof. J. Nijs, Prof P. Cras, Prof F. visser, M. de Kooning and colleaguesFaculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, BelgiumMERUK

Development of surrogate end-point biomarkers for chronic fatigue and myalgic encephalmyelitis/chronic fatigue syndrome (ME/CFS)



Lead researcher: Watanabe

Pet Scan study

Japan

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S4ME thread



Exploring Brain Inflammation

Lead researcher: Dr. Jarred Younger

University of Alabama, Birmingham (USA)

SMCI, Ramsay Award Program (2016)

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Lead researcher: WatanabePet Scan studyJapanLead researcher: Dr. Jarred YoungerUniversity of Alabama, Birmingham (USA)SMCI, Ramsay Award Program (2016)

Projects



Glial activation in brainstem



Massachusetts General Hospital

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S4ME thread



Dr. Michael VanElzakkerMassachusetts General Hospital

Autonomic system

ME/CFS: Activity Patterns and Autonomic Dysfunction