Donald and Melania Trump’s relationship has been a constant source of unbridled attention and speculation. From ongoing guesswork about the first lady’s body language towards the president to unverified, contested rumours purporting they sleep in separate beds, onlookers have relished in considering what goes on behind scenes.

Rosie O’Donnell, one of Mr Trump’s longest standing and most vocal critics, has now joined the swathes of people weighing in on their relationship.

The American comedian has urged Ms Trump to leave her husband and take their 11-year-old son Barron Trump with her.

The input was prompted by a tweet composed by the First Lady which said: “We must continually reaffirm our American values as we join with the international community to make our world safer!”

O’Donnell, a former host on The View, snapped back: "Which is why you need to divorce him - take your son and parents and FLEE."

Sevnica: Melania Trump's home town Show all 18 1 /18 Sevnica: Melania Trump's home town Sevnica: Melania Trump's home town The 12th-century castle dominates Sevnica old town Getty Images Sevnica: Melania Trump's home town The old town has a beautiful riverside setting Getty Images Sevnica: Melania Trump's home town 'White House' slippers in Sevnica castle Nick Redmayne Sevnica: Melania Trump's home town The annual salami festival, the Salamiada Nick Redmayne Sevnica: Melania Trump's home town Sevnica was a nondescript town before Melania hit the big time AFP/Getty Images Sevnica: Melania Trump's home town Sevnica butchers take their sausage-making skills seriously Nick Redmayne Sevnica: Melania Trump's home town Only men are allowed in the Salamiada Nick Redmayne Sevnica: Melania Trump's home town As American as.... a Sevnica apple pie Nick Redmayne Sevnica: Melania Trump's home town There are no plans to make a Donald pie Nick Redmayne Sevnica: Melania Trump's home town The slippers featured in a recent fashion show AFP/Getty Images Sevnica: Melania Trump's home town The castle is one of the top tourist sites in town Getty Images Sevnica: Melania Trump's home town Melanija cake has gone down a storm AFP/Getty Images Sevnica: Melania Trump's home town The smart house still owned by Melania's parents Nick Redmayne Sevnica: Melania Trump's home town They live in America but visit occasionally Nick Redmayne Sevnica: Melania Trump's home town The communist block of flats in which Melania grew up Nick Redmayne Sevnica: Melania Trump's home town Melania skin cream, for a presidential complexion Nick Redmayne Sevnica: Melania Trump's home town First lady chocolates, dusted with gold Nick Redmayne Sevnica: Melania Trump's home town Even locals can't get enough of the Melanija cake Nick Redmayne

Marking a significant break with tradition, the First Lady is currently living separately from the US President in Trump Tower in New York so Barron can finish the school year. According to reports she will be moving into the White House with him in June of this year.

It's worth noting that O’Donnell’s comments have not come from nowhere. She has an age-old feud with Mr Trump which goes way back to the mid-noughties. Back in 2006, O'Donnell criticised the billionaire businessman for holding a conference to announce Miss USA 2006, Tara Conner, could retain her crown after being criticised for publicly partying.

Since then, the pair have publicly criticised each other on more occasion than one. In one particularly angry rant on Entertainment Tonight in 2006, Mr Trump said: “Rosie O'Donnell is disgusting, both inside and out.”

“If you take a look at her, she's a slob. How does she even get on television? If I were running [US talk show] The View, I'd fire Rosie. I'd look her right in that fat, ugly face of hers and say, 'Rosie, you're fired.'“

He has also previously called her a "pig" and a "degenerate".

More recently, Mr Trump used his fiery debut presidential debate to argue that O’Donnell had deserved all of his pejorative remarks towards her.