There is a Mayhem in the now-defunct MC2 imprint, known largely for its depiction of Peter Parker's teenage daughter May as Spider-Girl. In this, Mayhem was a clone of Spider-Girl produced by combining May's DNA with the Venom symbiote's cells, giving the clone the ability to morph her body in ways similar to Venom. She was initially a pawn for Norman Osborn, but May convinced her to turn against Osborn and the clone became part of the family as May's strangely similar-looking cousin April Parker. Like Ben Reilly with Peter, April dyed her hair to distinguish herself from May, only curly black as opposed to May's straight brown, and she later took up the name Mayhem when she began acting as an anti-hero and embracing her darker side, much to the consternation of May.



Background details aside, this is actually a pretty interesting merger, and technically, we have seen Spider-Man merge with both symbiotes individually. The black suit is an infamous example, especially since Peter was the Venom symbiote's first host, and Carnage was something that happened three times in three different media. In the comics, it was Ben Reilly-as-Spider-Man that bonded with the Carnage symbiote; in the 90s animated finale, it was an alternate universe's Peter Parker that was driven completely insane by his bond with Carnage and decided to annihilate all reality as revenge for the lifelong pain and misery inflicted on him by the world in repayment for his heroism as Spider-Man; and in the Ultimate Spider-Man video game, it was the remnants of the Venom Suit inside his bloodstream that took him over and became Carnage. All the same, the new look for Spider-Man is pretty freaking awesome, though I'm sure it'd be really terrifying with the prerequisite symbiotic mouth. Great work.