Hollywood can eat talent up and spit it right back out. It’s hard to get a break, and even harder to stay relevant. The struggle to get to Hollywood can be difficult, and some have faced greater challenges than others. While these actors, writers, and directors have had to battle great odds to become successes, those battles have given them the strength to stay relevant in a town where fame is extremely fleeting.

Another great list you might enjoy is about famous trios from history. The list contains fictional and non-fictional characters who've made a name for themselves.