GOP Sen. Susan Collins Susan Margaret CollinsClub for Growth to spend million in ads for Trump Supreme Court nominee Maryland's GOP governor says Republicans shouldn't rush SCOTUS vote before election The Hill's Morning Report - Sponsored by Facebook - GOP closes ranks to fill SCOTUS vacancy by November MORE (Maine) said Friday that she will support Brett Kavanaugh's Supreme Court nomination, clinching the votes he needs to be confirmed.

"I will vote to confirm Judge Kavanaugh," Collins said at the end of a roughly 45 minute speech on the Senate floor.

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Collins rejected several of the

"Judge Kavanaugh has been unequivocal in his belief that no president is above the law," Collins said.

Collins also dismissed concerns from progressives and Democrats that Kavanaugh would provide a fifth vote for weakening or overturning Roe v. Wade, the landmark 1973 decision that established the right to an abortion. If confirmed, Kavanaugh will succeed former Justice Anthony Kennedy, who was the fifth vote on a 1992 case upholding Roe v. Wade.

"Protecting this right is important to me,” Collins said. “To my knowledge, Judge Kavanaugh is the first Supreme Court nominee to express the view that precedent is not merely a practice and tradition but rooted in Article Three," Collins said.

Almost no Democrats were present while Collins spoke, an apparent reflection of the increasingly clear signals she sent to colleagues over the past 24 hours that she would likely vote 'yes.'

A small group of protesters interrupted the beginning of her speech, chanting “Show up for women!” and “vote no.”

Another group of women dressed mostly in black stomped loudly out of the gallery above the chamber as Collins was midway through her speech.

Many of Collins’s GOP colleagues showed up to listen to her speech and show support.

Sen. Rob Portman Robert (Rob) Jones PortmanMcConnell locks down key GOP votes in Supreme Court fight Romney undecided on authorizing subpoenas for GOP Obama-era probes Congress needs to prioritize government digital service delivery MORE (R-Ohio), one of her closest friends in the Senate, whispered something in her ear shortly before she began speaking while Sen. Cory Gardner Cory Scott GardnerCook Political Report shifts Colorado Senate race toward Democrat Overnight Health Care: US coronavirus deaths hit 200,000 | Ginsburg's death puts future of ObamaCare at risk | Federal panel delays vote on initial COVID-19 vaccine distribution The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting MORE (R-Colo.), who, like Collins, faces a potentially tough re-election in 2020, cracked a joke with her as she walked to her desk.

Collins's decision means Kavanaugh will have at least 50 votes, the amount needed to let Vice President Pence break a tie during a final up-or-down confirmation vote if all senators are voting.

If Pence's vote is needed, it will be the first time a vice president has been used to cast the decisive, tie-breaking vote for a Supreme Court nominee.

It's possible Kavanaugh could get more than 50 votes. Senators voted 51-49 to end debate on his nomination Friday. Sen. Joe Manchin Joseph (Joe) ManchinManchin defends Supreme Court candidate Barrett: 'It's awful to bring in religion' The Hill's Morning Report - Sponsored by Facebook - Trump, GOP allies prepare for SCOTUS nomination this week Trump meets with potential Supreme Court pick Amy Coney Barrett at White House MORE (D-W.Va.), who voted to proceed with the confirmation process, announced immediately after Collins finished speaking on the floor that he will support the nominee during the final vote.

The support from Collins provides a major boost to Republicans, who faced a minor setback earlier in the day when Sen. Lisa Murkowski Lisa Ann MurkowskiClub for Growth to spend million in ads for Trump Supreme Court nominee Pebble Mine CEO resigns over secretly recorded comments about government officials Maryland's GOP governor says Republicans shouldn't rush SCOTUS vote before election MORE (R-Alaska) voted against proceeding with Kavanaugh's nomination.

Murkowski hasn't explicitly said she will oppose Kavanaugh's nomination on Saturday, but told reporters she had "wrestled" with the nomination, which she called the "most difficult" decision she has had to make.

"I believe that Brett Kavanaugh is a good man," Murkowski told reporters on Friday. "I believe he is a good man. It just may be that in my view he's not the right man for the court at this time."

Sen. Jeff Flake Jeffrey (Jeff) Lane FlakeHow fast population growth made Arizona a swing state Jeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Republican former Michigan governor says he's voting for Biden MORE (R-Ariz.), who announced last week that he would support Kavanaugh, reaffirmed on Friday that he would vote "yes" during Saturday's confirmation vote.

Collins's decision comes a day after senators viewed an FBI report on the agency's investigation into sexual assault allegations that have thrown Kavanaugh's nomination into chaos.

Collins told reporters on Thursday morning that she thought the investigation was "very thorough." She declined to say later in the day if she stood by that comment.

During her speech Friday, Collins said that some of the allegations against Kavanaugh were "outlandish," while noting that she believes Christine Blasey Ford, Kavanaugh's first accuser, was sexually assaulted.

"I believe that she is a survivor of a sexual assault and that this trauma has upended her life," Collins said.

But Collins said other individuals allegedly at the party where Ford says Kavanaugh sexually assaulted her in the early 1980s could not corroborate her account.

Collins added that if senators rejected Kavanaugh over the accusations it would be "hugely damaging to this confirmation process."

"This debate is complicated further by the fact that the Senate confirmation process is not a trial ... but certain fundamental legal principles about due process, the presumption of innocence and fairness do bear on my thinking and I cannot abandon them," Collins said.

She added that Ford's allegations did not meet the "more likely than not standard" but tried to stress that she was not saying sexual assault was not a serious problem in the country.

"The 'Me Too' movement is real. It matters. It is needed and it is long overdue," she said.

The Maine Republican has been at the center of the months-long Supreme Court fight and closely watched by her GOP colleagues in the final days of the fight over Kavanaugh's nomination.

Though she’s not up for reelection until 2020, outside groups have raised more than $1.8 million that they pledged to donate to a potential Democratic opponent if she supported Kavanaugh.

Collins blasted the Senate's confirmation fight, saying it has become "so dysfunctional it looks more like a caricature of a gutter-level political campaign instead of a solemn occasion."

Several protesters from the gallery overlooking the chamber interrupted Collins immediately after she began speaking, yelling,"Vote 'no,' show up for Maine women!"

She's also been frequently shadowed by colleagues, most notably Sen. Rob Portman (R-Ohio), and had lunch Friday with with a group of senators, including Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellFEC flags McConnell campaign over suspected accounting errors Poll: 59 percent think president elected in November should name next Supreme Court justice Mark Kelly: Arizona Senate race winner should be sworn in 'promptly' MORE (R-Ky.) and Sen. John Cornyn John CornynThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Liberal super PAC launches ads targeting vulnerable GOP senators over SCOTUS fight Senate GOP faces pivotal moment on pick for Supreme Court MORE (R-Texas), before her floor speech.

Some Republicans had voiced confidence that Collins would ultimately vote with them on Kavanaugh despite being at the center of a multimillion-dollar ad war meant to sway her vote. McConnell told reporters after Friday's lunch that he was feeling "optimistic" about the Saturday vote.

Roughly 20 Republican senators were on the Senate floor as Collins gave her speech, including Cornyn and McConnell, who had his chair turned to face her while she spoke.

GOP Sens. Shelley Moore Capito Shelley Wellons Moore CapitoCongress must finish work on popular conservation bill before time runs out Second GOP senator to quarantine after exposure to coronavirus GOP senator to quarantine after coronavirus exposure MORE (W.Va.) and Cindy Hyde-Smith (Miss.) sat behind Collins as she gave her speech. The two normally sit elsewhere on the Senate floor, and the move appeared to be aimed at showing there were other senators on the floor for those watching on TV.

-- Alexander Bolton contributed reporting. Updated at 5:30 p.m.