Former Queensland MP Scott Driscoll has been charged with multiple counts of fraud following an investigation by police and the state's corruption watchdog.

The 39-year-old is due to appear in court later this month on 16 charges, including soliciting secret commissions, fraud and fraudulent falsification of records, the Crime and Corruption Commission (CCC) said in a statement today.

It will be alleged that between August 2011 and May 2013 Driscoll committed fraud offences worth $725,000.

It is also claimed he solicited at least $400,000 in secret commissions from two entities, but never received the money.

"The CCC will not allege that the man ever received the secret commissions," the statement said.

Mr Driscoll resigned from the Brisbane bayside seat of Redcliffe in November 2013, after the Parliament's Ethics Committee recommend he be fined $90,000.

The committee had found him guilty of 49 counts of contempt for deliberately misleading Parliament and hiding his personal income and business dealings and recommended he be expelled.

Mr Driscoll won Redcliffe for the LNP in 2012, but he became an independent when the party lost confidence in him in March 2013.

Premier Campbell Newman today would not be drawn on the charges, saying the matter was for the courts.

Mr Driscoll is scheduled to appear in the Brisbane Magistrates Court on October 23.

His wife Emma also appeared in court this year on 13 fraud-related charges and perjury.

Police and the CCC began investigating Mr Driscoll in April 2013, and a brief of evidence was referred to the Director for Public Prosecutions to consider criminal charges in January this year.