Vandals have smashed the electoral office of Peter Dutton, who was vying for the Liberal leadership, with brick pavers thrown at the front windows and doors of his local headquarters at Strathpine, north of Brisbane.

Six windows have been smashed and the two front doors have holes in the laminated glass the size of a football.

Police said they believed no-one entered the building when it was damaged just before 2:00am.

Police have appealed for witnesses.

Authorities are also investigating graffiti on a footpath about 200 metres down the road from Mr Dutton's office.

Graffiti was also spray painted on a footpath about 200 metres from Mr Dutton's office. ( ABC News: Mark Slade )

Andrew Schloss, who works in a disability support centre next door, said it was not the first time Mr Dutton's office had been targeted.

"Everything from people dressed up as witches through to the 'get up and go people' — a lot of people out here saying 'free Manus Island' and so on," he said.

"It's usually his stuff around his portfolio, but not damage like this."

Police said they believed no-one entered the building when it was damaged about 2:00am. ( ABC News: Rachel Riga )

Peter Dutton lost the leadership ballot for the Liberal Party today after a noon showdown, with Scott Morrison elected as new leader.