A large section of the Brisbane River bank has slipped due to recent heavy rain over the Easter long weekend.

The slip of more than 40 metres of the river bank at Tennyson in the city's south has destroyed the local bikeway, walkway and threatens a nearby building.

Brisbane City Council has closed a section of Ken Fletcher Park near the landslip to prevent nearby residents from entering the area until repair work can be done.

Environment Parks and Sustainability committee chairman Councillor Matthew Burke said the area had been significantly damaged.

"We lost 600 square metres of land [soil] at Ken Fletcher Park and it is a major slip," he said.

"This is a natural occurrence as the river does from time-to-time slip and move.

"No one was injured or nearby when it happened, it could have been catastrophic if there was someone on the bike path at the time."

A temporary building situated on the riverbank is the council's main concern as it continues to move towards the river.

"We have moved the canoe club that was taking use of the temporary facility [building] out and we are working now at how we can remove the building," Cr Burke said.

"If we try to do piling work to restore the bank there is a big change that the building will fall into the river.

"We will remove the temporary structure and finding a new home for the canoe club in the process."

Storm water pipes cause worry

Further landslips have occurred in the area this week and Cr Burke said he believed it was due to storm water pipes beneath the nearby building.

"The soil continues to move and there is a network of storm water pipes, some dating back to the original power station," he said.

Sandbags line the landslip at Tennyson near the unstable building. ( 612 ABC Brisbane: Terri Begley )

"We believe one of the pipes may have cracked and saturated the soil and that is what has caused a further slip."

The council is reassuring residents that landslips are not occurring in other places along the river.

"Through the CBD we have river walls which offers protection, this section is not protected by a river wall so we can have natural occurrences like this," Cr Burke said.

"We are working with our engineers around this before we can give commitments to timeframes around the removal of the building and the re-opening to the public."

Sections of Ken Fletcher Park and the playground remain open.