Rob Reilly, a partner and worldwide chief creative officer at Crispin Porter + Bogusky, is leaving the agency to pursue “new ventures,” the shop said today.

In addition, his wife, Laura Bowles, a managing director, partner and veteran account leader at the agency, also is exiting.

In 2008, after top creative Alex Bogusky became co-chair at CP+B, Reilly and Andrew Keller assumed the top creative roles at the MDC Partners agency, as co-ecds. Two years later, Keller rose to CEO and Reilly became CCO.

In the wake of Reilly’s departure, CP+B said its creative department will be restructured to have "increased autonomy" at its offices in Miami, Boulder, Los Angeles, London and Gothenburg, Sweden. The ecds of those offices will report to Keller and be supported by Evan Fry, executive director of creative development and Dave Swartz, director of art and design.

During her 16 years at CP+B, Bowles has run Volkswagen, Ikea, Burger King and oversaw the U.S. launch of the Mini Cooper.

In a statement, Reilly said: “We have hired and grown so many great creative leaders, and this seems like the perfect time for me to step away, try some new challenges and put this structure into action. There is always a right way and a wrong way to leave a place that has played such a huge role in your life, and I believe this is the right way.”