Ms Pike — along with former Transport Minister Lynne Kosky — was the longest-serving female minister in Victorian politics.

She faced tight battles against Greens in the last two state elections, but was aided at the 2010 poll when the Liberals preferenced the Greens last on their how-to-vote cards.

Ms Pike said this afternoon that she had decided after the 2010 election that she would not be part of the next Labor government after serving more than 12 years in parliament.

"It is a chance for the party to renew and bring new people in and continue to build for the future," Ms Pike said.

She said approving the new Children's Hopsital as health minister in the Brumby government was one of her key achievements.