TV hostess Rachael Ray is “grief-stricken” after her pit bull bit the ear off another dog, the latest in a series of vicious fights involving the pooch.

Isaboo, a brown and white pit bull that Ray calls her “baby,” is familiar to her fans from appearances on “The Rachael Ray Show.”

In the latest incident, on Feb. 1, one of Isaboo’s handlers was walking her on a leash in Greenwich Village when she met another leashed dog, according to Radar Online.

“Isaboo lashed out . . . quickly and ripped the other dog’s ear off before its handler could pull it away,” the source said.

Isaboo’s handler notified Ray’s husband, John Cusimano, who contacted the other dog’s owner and “offered to pay for the medical bills, as well as any additional costs.”

The wounded dog was taken to a veterinarian, who was able to save part of its severed ear. The owner of the other dog has refused comment.

When Cusimano told Ray about the incident, the source said, the celeb was “grief-stricken.” The couple is now thinking about putting a muzzle on Isaboo and giving her extra training.

But the report also said that Ray was worried that her beloved pet had become such a menace, and knows she might have to be euthanized.

“While she loves the dog, she can’t help worrying what would happen if Isaboo attacked a person,” Radar reported.

A spokesman for Ray, Charlie Dougiello, insisted that “Isaboo is one of the warmest and most loving dogs I’ve ever been around.”

Isaboo has been in other dogfights, and Ray reportedly received a gash on her hand in 2007 when she tried to get between her dog and another.