Rosie O'Donnell and Madonna at The Plymouth Theater in New York City.

In last night’s debate, Donald Trump inexplicably revived his decade-old feud with Rosie O’Donnell, doubling down on the times he’s called her a “pig,” “fat,” a “slob,” and numerous other repulsive insults. In response, Rosie's longtime friend Madonna came out swinging.

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Madge dug up a shot of her with her co-star from the 1992 cable classic A League of Their Own, and along with it offered a few words for the Republican nominee. “Mess with my girl Rosie and you’re messing with me,” Madonna exclaimed. “Cruelty never made anyone a winner.”

Mess with my girl Rosie and you're messing with me!!! Cruelty never made anyone a winner. ?? #rebelhearts4ever pic.twitter.com/gvkF6HpU47 — Madonna (@Madonna) September 27, 2016

Most major arbiters called Hillary Clinton the winner of last night’s debate, so on this point, Madonna is indeed very tough to dispute. You can view Trump’s anti-O’Donnell diatribe below:

.@RealDonaldTrump on Rosie O'Donnell comments: "she deserved it and nobody feels sorry for her" #DebateNight https://t.co/yuutX34GN0 — Sky News (@SkyNews) September 27, 2016

For more on last night's presidential sound-off, check Billboard’s roundup of how Katy Perry, Chance the Rapper and others reacted to the first Donald Trump vs. Hillary Clinton debate.