The woman who accuses Prince Andrew of having sex with her when she was 17 appears to have tweeted an eerie message to say she is not suicidal - just in case something happens to her.

Former American Virginia Roberts Giuffre, who now lives in Queensland, says she was a teenager when she was trafficked by dead paedophile Jeffrey Epstein to have sex with Prince Andrew in 2001.

Epstein died in a New York prison of an apparent suicide in August this year, about a month after his arrest on sex trafficking charges.

However, many people believe Epstein was murdered in an effort to keep him quiet about his many high-profile friends who may have participated in his sex parties at various locations across the world.

"I am making it publicly known that in no way, shape or form am I suicidal," Giuffre said via a Twitter account that appears to be genuine on Wednesday.

"I have made this known to my therapist and GP - If something happens to me - (for) the sake of my family do not let this go away and help me to protect them. Too many evil people want to see me quietened."

Abuse allegations

The 36-year-old recently gave an interview to the BBC program Panorama and alleged she had been forced to have sex with Prince Andrew three times - in New York, London and on Epstein's private Caribbean island.

It came just a few weeks after Prince Andrew gave a badly received interview to the BBC in which he "categorically denied" having sex with Giuffre.

The 59-year-old royal also denied ever having met Giuffre.

On the night she alleges they had sex after going to a London nightclub, the prince said he had taken his daughters to a pizza restaurant and so the liaison could not have occurred.

The widely circulated photo of Prince Andrew with the 17 year-old Virginia Roberts and Ghislain Maxwell taken inside her Belgravia apartment. Credit: Supplied / Virginia Roberts Giuffre

Jeffrey Epstein and Ghislaine Maxwell in 2005 and inset, Prince Andrew. Credit: Getty/AP

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The Duke of York also said he could not recall Epstein taking a picture of the royal with his hand around Giuffre's waist, and Epstein's friend Ghislaine Maxwell - who is accused of helping Epstein traffick young women and girls - in the background, suggesting the image could have been faked.

Just four days after the interview, Prince Andrew stood down from all public duties.

Conspiracy theories

One of Giuffre's followers said in reply to the tweet: "You aren't suicidal, and if you die in an 'accident', it wasn't no accident."

The tweet comes as British newspaper The Sun reports that Ghislaine Maxwell is set to do a US TV interview in order to defend Prince Andrew against the underage sex claims.

Ghislaine Maxwell in 2000. Credit: Matthew Polak / Sygma via Getty Images

The controversy surrounding Prince Andrew continues to deepen Credit: GETTY

Maxwell has not been seen in public since June and The Sun is offering a 10,000 pound ($A20,000) reward for information leading to her being found.

"Ghislaine is in hiding and knows the only way to stop being hunted is to speak on her own terms," an unnamed source told the paper.

“She will do a sit-down interview with a big US network and defend the Duke.

"Apparently, she’ll say Virginia Giuffre is lying and Andrew never had sex with her,” the source said.