A man in his 30s has been arrested for suspected impaired driving after a crash on the QEW in Mississauga early Sunday morning sent six people to hospital.

The crash has prompted lane closures on the QEW. Ontario Provincial Police say one eastbound lane on the QEW from Hurontario Street to Cawthra Road is now open, while the other eastbound lanes remain closed. Two right westbound lanes are now open at Dixie Road.

Peel paramedics said they took two people with serious but not-life threatening injuries to a trauma centre in Toronto and four people with minor injuries to a local hospital. Police and paramedics were called to the scene shortly after 4:00 a.m.

About 10-metres of guardrail will need to be repaired as a result of the crash, according to provincial police. (Sgt. Kerry Schmidt/Twitter) The crash involved two vehicles, both of which rolled over, according to Sgt. Kerry Schmidt, spokesperson for the OPP's Highway Safety Division.

"As the vehicles rolled and tumbled across the highway, they took out a large section of the steel guardrail that separates directions of highway," Schmidt said.

"There was debris across all lanes. Several vehicles travelling westbound also sustained damage as a result of debris going into the lanes but no injuries were reported in those incidents."

Schmidt says the lane restrictions will follow the road closures give crews from Ontario's ministry of transportation time to repair nearly 10 metres of guardrail. OPP anticipate the repairs will take several hours.

OPP trying to piece together what led to crash

Police said they are trying to determine the circumstances that led to the crash. Both vehicles were travelling eastbound when they collided.

Five of the injured were in an SUV, while the sixth injured person, the driver of a sedan, was taken to hospital as a precaution, Schmidt said.

The driver could be facing two counts of impaired driving causing bodily harm, he added.

The OPP's Port Credit detachment, along with a collision reconstruction team, is investigating.

Anyone with dashboard camera video or relevant information is urged to call the OPP at (905) 278-6131.