If your glass desk has a 2 inch hole in the back to mount the base to, then yes it should work fine. I love the stand as it lets me swivel up down and sideways and this allows me to fix or adjust the connections in the back without finding a way to go under the monitor...Make sure your monitors have vesa ports or holes in the back that fit the limited bracket holes on the mount. I had one that sat on the desk and liked it well until I bought this one. But it is an option if you do not have hole and the desk is against the wall. Good luck and remember the cable hiders work weird until you get used to them,,,bottom slides forward and front one pops off.