Two children have been injured by shattered glass from an awning, after a woman fell from the Aurora Towers Oaks building in Queen Street in Brisbane's CBD.

The Queensland Ambulance Service (QAS) attended the scene on Queen Street, near Customs House.

The woman's death is not being treated as suspicious.

A QAS spokesman said two children under 10 years of age suffered cuts from the falling glass.

They have been taken to the Queensland Children's Hospital at South Brisbane in a stable condition.

A witness told the ABC he saw the incident and called triple-0.

Police said the two children were sitting on the bench with their mother.

Inspector Steve Flori said they were "lucky to be alive" after the woman narrowly missed them.

"It's a sad event just before Christmas for everybody … we wish these two children and their mother well in recovering from having to witness this very sad event," Inspector Flori said.

He said the children had to be transported to hospital to have some of the glass shards removed.

"The events occurred within centimetres from where this woman was sitting with these two children, and it's only a stroke of luck or an act of God that has prevented them from being seriously hurt or killed," he said.

The mother was not injured.

Queen Street near Eagle Street was closed by police for several hours while crews spent the afternoon cleaning up the remaining glass.

Callie Wood was with a group of friends in one of the apartments getting ready for a birthday party.

"We were just sitting up there and we heard a bang, thinking it was a car crash maybe, we looked down and it was just chaos," she said.

"It was horrible — I think we're all a bit in shock to be honest — don't know how to react."