New research shows that nanoparticles carrying a toxin found in bee venom are capable of destroying HIV cells while leaving others intact. Researchers at Washington University in St. Louis (WU) say they’ve found a way to effectively destroy the HIV virus using a toxin found in bee venom. The study, published Thursday in the journal Antiviral Therapy, states that the technique not only destroys the virus that causes AIDS, but also leaves surrounding cells intact. Researchers say they hope the nanoparticle technology could be incorporated into a vaginal gel to prevent the spread of HIV in areas with high rates of infection.

How Nanoparticles & Bee Venom Destroy HIV Microscopic nanoparticles have unique and exciting properties. In biomedicine, they are used to transport important proteins throughout the body. Bee venom’s principle toxin is melittin, a small protein. Researchers used nanoparticles to distribute melittin in laboratory studies. Similar to the way a bee injects its venom into your skin using its stinger, the toxin melittin is able to poke holes in the protective coating of HIV and other viruses.



“We are attacking an inherent physical property of HIV,” Dr. Joshua L. Hood, a research instructor in medicine at WU, said in a press release. “Theoretically, there isn’t any way for the virus to adapt to that. The virus has to have a protective coat, a double-layered membrane that covers the virus.” When researchers loaded the toxin into nanoparticles, they found that it didn’t harm normal cells because of a protective bumper added to the nanoparticle’s surface. Because HIV cells are smaller than regular cells, they slide between the bumpers while leaving healthy, normal cells intact. Most current HIV treatments focus on inhibiting HIV’s ability to replicate, but do nothing to stop the initial infection. However, researchers say that because the venom-laced nanoparticles attack a crucial part of HIV’s structure, they can kill before the virus has a chance to infect a person.