Product Description

Lorcaserin (1431697-94-7) video

Raw Lorcaserin(1431697-94-7) HCL powder basic Characters

Name: Lorcaserin hydrochloride powder CAS: 1431697-94-7 Molecular Formula: C11H15Cl2N Molecular Weight: 232.1525 Melt Point: 212°C Storage Temp: -20℃ Color: White powder

What is Lorcaserin

Lorcaserin (CAS 1431697-94-7), marketed under the brand name is BELVIQ, the main ingredient is Lorcaserin HCL powder 846589-98-8. The FDA approved lorcaserin HCL for people who are obese (with a body mass index, or BMI, of 30 or higher) or who are overweight (with a BMI of 27 or above) and also have at least one weight-related health condition such as Type 2 diabetes, high blood pressure or high cholesterol.

What is Lorcaserin use for

Lorcaserin HCL powder 846589-98-8, is in a class of drugs known as serotonin receptor agonists. Lorcaserin HCL is used along with diet and bodybuilding to treat obesity, for fat loss. It is sometimes given to treat obesity associated with high cholesterol, high blood pressure, or type2 diabetes. But Lorcaserin hydrochloride(Lorcaserin HCL) will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure).

Lorcaserin mechanism of action

Lorcaserin hydrochloride powder works by controlling appetite — specifically by activating brain receptors for serotonin, a neurotransmitter that triggers feelings of satiety and satisfaction. Intake of food is controlled by satiety center, located in ventromedial nucleus of hypothalamus and hunger center present in lateral hypothalamus. Various inputs from higher centers and gastrointestinal tracts converge in arcuate nucleus, where two types of neurons controlling food intake is present. Firstly, food intake stimulatory group producing agouti-related protein and neuropeptide Y; and secondly, food intake inhibitory group containing cocaine and amphetamine regulated transcript (CART) and pro-opiomelanocortin (POMC) neurons. POMC contains 5-HT 2C receptors, which when activated releases alpha-melanocyte-stimulating hormone (alfa-MSH).Both inhibitory and stimulatory neurons further projects paraventricular nucleus in the hypothalamus.Paraventricular nucleus contains melanocyte 4 receptors (MC4R) that inhibits appetiteIn therapeutic doses lorcaserin acts as a selective 5-HT 2C agonist on POMC neurons, which in turn causes release of alfa MSH. Further alfa MSH acts on MC4R in paraventricular nucleus in the hypothalamus, leading to decrease in appetite. In supratherapeutic doses, lorcaserin also acts on 5-HT 2B and 5-HT 2A receptors.

How to use Lorcaserin HCL powder (CAS 1431697-94-7)

Lorcaserin HCL powder is a white to off-white powder with solubility in water greater than 400 mg/mL. Each BELVIQ XR tablet contains 20.8 mg of crystalline lorcaserin hydrochloride hemihydrate, equivalent to 20.0 mg lorcaserin hydrochloride powder, and the following inactive ingredients: microcrystalline cellulose NF; mannitol USP; hypromellose 2208 USP; ethylcellulose dispersion Type B NF; hypromellose 2910 USP; colloidal silicon dioxide NF; polyvinyl alcohol USP; polyethylene glycol NF; titanium dioxide USP; talc USP; FD&C yellow #6/sunset yellow FCF; aluminum lake; iron oxide yellow NF; iron oxide red NF; and magnesium stearate NF.

Lorcaserin HCL powder 846589-98-8 comes in tablet form and is taken typically 1-2 times a day, with or without food. Lorcaserin must be used along with a reduced calorie diet and an exercise plan.

Lorcaserin Interactions

-monoamine oxidase inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Emsam, Eldepryl, Zelapar), rasagiline (Azilect)

-selective serotonin reuptake inhibitors (SSRIs) such as escitalopram (Lexapro), sertraline (Zoloft), citalopram (Celexa), paroxetine (Paxil), fluoxetine (Prozac, Sarafem), and fluvoxamine (Luvox)

-tricyclic antidepressants such as trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil), and clomipramine (Anafranil)

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