Seahawks at Titans, 4:05 p.m. on Fox

Line: Titans by 2.5

The Seahawks (1-1) have been horrid offensively, and a lot of the blame has been placed on the team’s offensive line. Pro Football Focus backs that blame up by rating three of the team’s five starters as “poor,” with Rees Odhiambo, the team’s starting left tackle, picking up the rear with a player rating of 25.9 that ranks 72nd among tackles. The interesting thing, though, is that according to Sportradar, Russell Wilson has had an average of 2.57 seconds in the pocket before he releases the ball or the pocket collapses, which is better than last season’s mark of 2.29 seconds, and is the fifth most time of any quarterback. He has been hit an average of 6.5 times a game, which is tied for the 12th most, and has been sacked six times, which is tied for 9th. Wilson undoubtedly could use better protection, but placing all of the blame on the guys up front may be misguided. In the meantime, Seattle’s defense is mostly making up for the offensive inadequacy, and should be able to handle Tennessee (1-1), especially if DeMarco Murray is unable to play. Pick: Seahawks

Giants at Eagles, 1 p.m. on Fox

Line: Eagles by 6

Coach Ben McAdoo of the Giants (0-2) did not hold back during a conference call this week.

“Yeah, we can’t keep doing the same thing over and over again,” McAdoo said. “That’s insanity. It’s not working. So we are going to look to make some changes this week, like we did last week. Maybe it will be a little more drastic this week, to use your word.”

It is hardly sunshine and puppy dogs in Philadelphia, as the Eagles (1-1) are struggling to find any sort of offensive balance, and have some key injuries on defense, but playing at home against a team in disarray can do a lot to make a team look like it has everything together. Pick: Eagles

Buccaneers at Vikings, 1 p.m. on Fox

Line: N/A

No one is sure what to make of this game since the status of Minnesota’s starting quarterback, Sam Bradford, has yet to be determined. The Vikings (1-1) looked terrific in Week 1, with Bradford earning N.F.C. offensive player of the week honors for his performance against New Orleans, but a knee injury kept him out of Week 2 and the result was a 26-9 loss to Pittsburgh. If Bradford, who practiced in a limited capacity on Wednesday, is able to play, Minnesota would seemingly be at an advantage, but without him the Vikings will struggle to score, even though his backup, Case Keenum, has a 2-0 record against Tampa Bay (1-0) over the last two seasons. Pick: Vikings

Broncos at Bills, 1 p.m. on CBS

Line: Broncos by 3

Denver (2-0) barely escaped with a victory in Week 1, but then absolutely dominated one of the N.F.L.’s best teams in Week 2, so figuring out exactly where they fit leaguewide can be difficult. Trevor Siemian may not be able to reel off four passing touchdowns every week, but if the team’s run defense can play as well as it did while humiliating Ezekiel Elliott, then the Broncos will be no fun for opponents. Buffalo (1-1) will do its best to get something going with LeSean McCoy, but the Bills will eventually need to throw the ball, and it’s hard to believe that Tyrod Taylor can find openings with Aqib Talib and Chris Harris Jr. roaming the field. Pick: Broncos