At least 12 people have been injured in an early morning blaze in Manhattan.

New York firefighters were battling the fire on the 29th floor of a building located at 1295 Fifth Avenue in East Harlem.

Authorities said one adult and two children who were hospitalized with life-threatening injuries.

The fire was reported around 6.45am and it was under control by 7.52am.

At least 12 people have been injured in an early morning blaze in Manhattan. New York firefighters were battling the fire on the 29th floor of a building located at 1295 Fifth Avenue (pictured) in East Harlem

Authorities said one adult and two children who were hospitalized with life-threatening injuries. The fire was reported around 6.45am and it was under control by 7.52am

The early morning fire on Sunday broke out at 1295 Fifth Avenue (pictured)

According the FDNY, two people were found in a hallway, while others were found inside an apartment on the same floor.

One New Yorker posted a video of the fire on Twitter.

'Fire in the building across the street. FDNY on site quickly, with massive response. Couple of people have been carried out on stretchers,' the user tweeted.

The video shows thick smoke coming from one of the building's windows as firefighters sprayed water on the blaze from inside the complex.

Authorities are investigating the fire to determine what caused it.

The fire in Harlem comes just hours after three people were killed and eight others injured in a house fire in Queens.

The fire in Harlem comes just hours after three people were killed and eight others injured in a house fire in Queens (pictured)

Authorities said the blaze broke out late Saturday night at a two-story home. An 82-year-old woman, an 87-year-old man and a 32-year-old woman were all killed in the fire

Eight other people were taken to area hospitals. Three, including an eight-year-old girl, have been listed in critical condition

Authorities said the blaze broke out late Saturday night at a two-story home.

An 82-year-old woman, an 87-year-old man and a 32-year-old woman were all killed in the fire.

Eight other people were taken to area hospitals. Three, including an eight-year-old girl, have been listed in critical condition.

The other five are hospitalized in stable condition with injuries that are not believed to be life-threatening.

It took 138 firefighters nearly 90 minutes to get the three-alarm blaze under control.

The cause of the Queens fire remains under investigation.