In 2014, Karen Kirsch lost Wayne Best Jr., whom she helped raise and considered her son, to gun violence. And now the Schenectady woman has lost her home in what police and fire investigators are probing as a suspicious fire Friday that gutted 1052-1054 Parkwood Blvd.

It was outside the home along this quiet street on the city’s North side where Best, 25, was gunned down during the early morning hours of Dec. 9, 2014

Kirsch, who was home when the fire erupted around 12:30 a.m. Friday had to be rescued by firefighters from the upstairs apartment.

Three other tenants downstairs made it out safely.

Kirsch, who was initially taken to Ellis Hospital was later transferred downstate to Westchester Medical Center for treatment.

Late Friday, investigators used a rake and shovel and were assisted by a fire dog as they combed through the debris, mostly focusing on the front porch of the charred remains of the home. It was later demolished.

The inferno happened on the same day 29-year-old Todd Macon, one of the defendants arrested in the Best slaying pleaded not guilty in count court to a 10 count indictment, that includes charges of second-degree murder and robbery offenses.

His co-defendant, Christopher Johnson, 25, is scheduled to be arraigned next week on similar charges.

The criminal complaint says Best was shot in the chest with a .25-caliber gun during an attempted robbery even the attorneys for Macon and Johnson have said their clients are not the shooter.

Schenectady County District Attorney Robert Carney has said they expected to make more arrests.

Best was well-known and involved in water-skiing, riding BMX bikes and skateboarding. He competed in the 2006 Empire State Games in lacrosse.

During a December graveside memorial at Best’s grave in Vale Cemetery, Best’s parents, relatives, and friends planted a Christmas tree and made emotional appeals for the public’s help in the then unsolved homicide.

Kirsch said she fears that Johnson and Macon were part of a group that followed Best from the Saw Mill, South Avenue bar, and tried to rob him of $300.

The probe was handled by city police, prosecutors, the State Police and the U.S. Bureau of Alcohol, Tobacco, Firearms and Explosives.