Ryan Mathews was already ruled out of Sunday's game against the Seattle Seahawks with a knee injury.

According to ESPN's Adam Caplan, Mathews has suffered a sprained MCL and will be further evaluated in 24 hours.

Initial word on #Eagles RB Ryan Mathews: MCL sprain, source said. He'll be further evaluated over next 24 hours. #PHIvsSEA — Adam Caplan (@caplannfl) November 20, 2016

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Mathews had seven carries for 31 yards prior to the injury. The Eagles are without their top two running backs as Darren Sproles also left the game with a rib injury.