Alas, it seems that for A.P. Bio, school’s out both for the summer and forever. NBC canceled the comedy in the back end of its second season, prompting the usual wave of disappointment among fans who wished the network would have let the series continue to grow. Now costars Patton Oswalt and Glenn Howerton are trying to save it. Could they possibly succeed?

For the uninitiated, A.P. Bio stars Howerton as a disgraced Harvard philosophy professor named Jack Griffin who moves back to his hometown of Toledo, Ohio, and gets a job teaching advanced placement biology. Rather than teach his students much of anything, however, Jack decides to use their brains for his own gain—whether it be through revenge schemes or crowdsourcing market research for a new book. Oswalt plays Principal Durbin, who tries to rein Jack in.

NBC canceled the series on Friday; by Saturday, the hashtag “#SaveAPBio” was trending on Twitter.

Oswalt immediately began retweeting fan eulogies and pleas to save the show—including a few from celebrities like Paula Pell and Mark Hamill. He encouraged fans to binge the series over Memorial Day weekend, and has continued retweeting messages of support and admiration for the show.

In addition to Oswalt, executive producer Seth Meyers and creator Mike O’Brien have joined the effort to save their show. O’Brien seems particularly miffed at NBC’s apparent focus on overnight ratings; addressing a fan who tweeted their regret for not watching the show the night it airs, O’Brien tweeted, “I’m saying none of you should have to apologize for how you watch it. The people airing the shows need to adjust to you. And some have. But I still see all the articles quote our NightOf numbers. Someone needs to post our dvr/streaming numbers and compare to other canceled shows.”

Fan campaigns to save canceled shows have grown increasingly common as social media offers the most ardent viewers an avenue to voice their frustration. Sometimes, these efforts can work; just look at Timeless, which NBC brought back from the dead after fans decried its cancellation after season one. (That said, the series was subsequently canceled again and granted one final movie to wrap things up.) A more encouraging success story might be Brooklyn Nine-Nine, which NBC picked up after Fox chose to cancel it. Most of the time, however, shows that get canceled still stay canceled—as with One Day at a Time, which remains kaput despite fan outcry and interest from outside parties to save it from Netflix. So although momentum behind A.P. Bio does appear to be building, at least on social media, it might be best to temper any expectations.

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