Runaway Premier League leaders Liverpool named an entirely changed starting line-up for their FA Cup fourth-round tie at Shrewsbury as top-flight sides made over six alterations on average.

The Reds sit 16 points clear at the league summit with a game in hand but, given their continued participation in other competitions, manager Jurgen Klopp opted to make wholesale changes.

All 11 of the team that started the 2-1 win over Wolves on Thursday dropped out as a mixture of fringe players and youth talent took centre-stage.

Klopp's young side looked to be getting the job done as they went 2-0 up through Curtis Jones' opener and Donald Love's own goal right at the start of the second half, but substitute Jason Cummings was introduced on the hour mark and bagged a brace to earn the Shrews a replay.

In Monday night's match at the Vitality Stadium, both Eddie Howe and Mikel Arteta introduced fresh faces to their respective line-ups.

50 biggest January transfers Show all 52 1 /52 50 biggest January transfers 50 biggest January transfers 50 most expensive January transfers Click through the gallery to see the biggest deals, steals and flops in history. Getty 50 biggest January transfers 50. Paco Alcacer (£19.4m) Borussia Dortmund to Villarreal (2020) Bongarts/Getty Images 50 biggest January transfers 49. Enzo Perez (£19.5m) Benfica to Valencia (2015) AP 50 biggest January transfers 45= Yohan Cabaye (£20m) Newcastle to Paris Saint-Germain (2014) 2015 VI-Images 50 biggest January transfers 45= Odion Ighalo (£20m) Watford to Changchun Yatai (2017) Getty Images 50 biggest January transfers 45= Morgan Schneiderlin (£20m) Manchester United to Everton (2017) Getty Images 50 biggest January transfers 45= Theo Walcott (£20m) Arsenal to Everton (2018) Reuters 50 biggest January transfers 44. Lucas Tousart (£20.3m) Lyon to Hertha Berlin (2020) Getty 50 biggest January transfers 42= Nemanja Matic (£21m) Benfica to Chelsea (2014) Twitter/@ChelseaFC 50 biggest January transfers 42= Miguel Almiron (£21m) Atlanta to Newcastle (2019) Getty Images 50 biggest January transfers 40= David Luiz (£21.5m) Benfica to Chelsea (2011) GETTY IMAGES 50 biggest January transfers 40= Stanislav Lobotka (£21.5m) Celta Vigo to Napoli (2020) AFP/Getty Images 50 biggest January transfers 39. Sander Berge (£22m) Genk to Sheffield United (2020) Getty Images 50 biggest January transfers 38. Paco Alcacer (£22.7m) Barcelona to Borussia Dortmund (2019) AFP/Getty Images 50 biggest January transfers 37. Luis Suarez (£22.8m) Ajax to Liverpool (2011) EPA 50 biggest January transfers 36. Krzysztof Piatek (£22.8m) AC Milan to Hertha Berlin (2020) REUTERS 50 biggest January transfers 35. Juan Cuadrado (£23.3m) Fiorentina to Chelsea (2015) Getty 50 biggest January transfers 31= Ramires (£25m) Chelsea to Jiangsu Suning (2016) Getty Images 50 biggest January transfers 31= Dimitri Payet (£25m) West Ham to Marseille (2017) Getty 50 biggest January transfers 31= Steven Bergwijn (£25m) PSV to Tottenham (2020) Getty 50 biggest January transfers 31= Lucas Moura (£25m) Paris Saint-Germain to Tottenham (2018) AFP via Getty Images 50 biggest January transfers 30. Goncalo Guedes (£25.5m) Benfica to Paris Saint-Germain (2017) EPA 50 biggest January transfers 29. Reinier (£25.6m) Flamengo to Real Madrid (2020) Getty 50 biggest January transfers 28= Gabriel Jesus (£27m) Palmeiras to Manchester City (2017) Visionhaus 50 biggest January transfers 28= Cenk Tosun (£27m) Besiktas to Everton (2018) Getty 50 biggest January transfers 27. Wilfried Bony (£27.5m) Swansea to Manchester City (2015) Getty 50 biggest January transfers 26. Inigo Martinez (£28m) Real Sociedad to Athletic Club (2018) GETTY IMAGES 50 biggest January transfers 25. Dejan Kulusevski (£29.8m) Atalanta to Juventus (2020) AP 50 biggest January transfers 24. Giovani Lo Celso (£30m) Real Betis to Tottenham (2020) REUTERS 50 biggest January transfers 23. Willian (£30m) Anzhi Makhachkala to Chelsea (2013) Getty 50 biggest January transfers 22. Krysztof Piatek (£30.9m) Genoa to AC Milan (2019) Getty 50 biggest January transfers 21. Lucas Paqueta (£31.4m) Flamengo to AC Milan (2019) EPA 50 biggest January transfers 19= Shoya Nakijima (£31.5m) Portimonense to Al-Duhail (2018) Getty 50 biggest January transfers 19= Edin Dzeko (£31.5m) Wolfsburg to Manchester City (2011) Getty Images 50 biggest January transfers 18. Julian Draxler (£34.1m) Wolfsburg to Paris Saint-Germain (2017) Getty 50 biggest January transfers 17. Leandro Paredes (£34.7m) Zenit to Paris Saint-Germain (2019) GETTY IMAGES 50 biggest January transfers 16. Andy Carroll (£35m) Newcastle to Liverpool (2011) Getty 50 biggest January transfers 15. Cedric Bakambu (£35.3m) Villarreal to Beijing Guoan (2018) Getty 50 biggest January transfers 14. Jackson Martinez (£35.7m) Atletico Madrid to Guangzhou Evergrande (2016) Getty Images 50 biggest January transfers 13. Juan Mata (£37.1m) Chelsea to Manchester United (2014) Manchester United via Getty Imag 50 biggest January transfers 12. Lucas Moura (£38m) Sao Paulo to PSG (2013) Getty Images 50 biggest January transfers 11. Alex Teixeira (£38.5m) Shakhtar Donetsk to Jiangsu Suning (2016) AFP/Getty 50 biggest January transfers 10. Paulinho (£44.2m) Barcelona to Guangzhou Evergrande (2019) Getty Images 50 biggest January transfers 9. Bruno Fernandes Sporting to Manchester United (£46.5m) Getty 50 biggest January transfers 8. Fernando Torres (£50m) Liverpool to Chelsea (2011) Getty 50 biggest January transfers 7. Oscar (£52m) Chelsea to Shanghai SIPG (2017) Getty 50 biggest January transfers 6. Pierre-Emerick Aubameyang (£56m) Borussia Dortmund to Arsenal (2018) PA 50 biggest January transfers 5. Diego Costa (£57m) Chelsea to Atletico Madrid (2017) Getty 50 biggest January transfers 4. Aymeric Laporte (£57.2m) Athletic Club to Manchester City (2018) Getty Images 50 biggest January transfers 3. Christian Pulisic (£57.5m) Borussia Dortmund to Chelsea (2019) PA 50 biggest January transfers 2. Virgil van Dijk (£75m) Southampton to Liverpool (2018) REUTERS 50 biggest January transfers 1. Philippe Coutinho (£106m) Liverpool to Barcelona (2018) AFP/Getty Images

Bournemouth boss Howe made six alterations for the visit of the Gunners, while Arteta named five different players from the side that drew 2-2 against Chelsea at Stamford Bridge.

Eddie Nketiah started his first game of the campaign for Arsenal following a loan spell with Leeds, and he scored his side's second of the night as the north London club progressed to the next stage with a 2-1 win.

The 14 Premier League sides who played in the fourth round made on average 6.14 changes to the team that started their previous match.

After Liverpool it was Leicester who made the next highest number of alterations of the top-flight sides in action over the weekend as Brendan Rodgers shuffled his pack for the trip to Brentford.

The Foxes, showing nine changes with only Caglar Soyuncu and Ayoze Perez retained from the midweek win over West Ham, still had enough to secure a 1-0 win through Kelechi Iheanacho's early effort.

Fellow top-four sides Chelsea and Manchester City made eight changes apiece for their ties against Sky Bet Championship opposition.

Frank Lampard handed a rare start to Michy Batshuayi at Hull and he provided the opening goal, with recalled defender Fikayo Tomori also finding the back of the net in a 2-1 victory which saw only Cesar Azpilicueta, Mateo Kovacic and Callum Hudson-Odoi keep their spots.

City cruised through at home to Fulham, largely thanks to an early red card for Tim Ream.

Pep Guardiola followed Lampard's lead by naming just three of the side who started the Premier League win over Sheffield United.

Gabriel Jesus missed a penalty against the Blades but made up for that by notching a double in a 4-0 success, with Riyad Mahrez and Nicolas Otamendi also included once again.

The fewest changes came from Tottenham, with Jose Mourinho potentially identifying the FA Cup as his best chance of landing his first trophy at the club.

But things did not go to plan at in-form Southampton as Spurs, with only three changes from their last league outing against Norwich, were pegged back late on to draw 1-1.

New signing Gedson Fernandes made his full debut as Davinson Sanchez and Japhet Tanganga also started, with Southampton's four alterations seeing Danny Ings return but unable to add to his impressive recent scoring record.

Manchester United, losers at home to Burnley on Wednesday night and with the second leg of their Carabao Cup semi-final against neighbours City coming up, showed six changes at Tranmere.

Ole Gunnar Solskjaer rotated more than half of his starting line-up against Tranmere (PA)

Ole Gunnar Solskjaer would have still been after a response and he got just that as the Red Devils romped to a 6-0 win on a poor pitch - Diogo Dalot, Jesse Lingard and Mason Greenwood all finding the back of the net on their returns to the starting XI.

Fresh from that famous win at Old Trafford, Burnley boss Sean Dyche made five changes of his own as the Clarets were beaten at home by the Premier League's bottom side Norwich, who themselves rotated seven players.

West Ham, struggling for league form, somewhat surprisingly made only the four changes but were still beaten 1-0 at home by Championship leaders West Brom.

Sheffield United and Newcastle made five alterations apiece but fared differently in their respective ties.

The Blades won 2-0 at Millwall despite changing half of their outfield players but Steve Bruce's Newcastle were held at home to a goalless draw by League One play-off hopefuls Oxford.