"What worries me very much is the breaking down of international cooperation," Sanders told MSNBC's "Morning Joe."

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"On the other hand, I think what this vote is about is an indication that the global economy is not working for everybody," he continued.

"It's not working in the United States for everybody and it's not working in the U.K. for everybody."

The Democratic presidential hopeful has focused much of his campaign on economic inequality and criticized international trade agreements the U.S. has engaged in. On Friday, he called for more international cooperation but added that "we do not forget about the people left behind."

Sanders's remarks came after Britain voted to leave the EU, a stunning result that prompted immediate global financial uncertainty and a plunge in value for the British pound.

British Prime Minister David Cameron, who advocated remaining in the EU, said he would step down amid speculation over the U.K.'s future.