Hundreds of Richmond residents have called on the Andrews government to reconsider its opposition to safe injecting rooms following the deaths of 34 drug addicts in the laneways of North Richmond last year.

A crowd of about 600 listened to the heart-wrenching accounts of families who had lost loved ones to drug addiction, which they insist could have been prevented.

Protesters rally in Victoria Street, Richmond, for a safe injecting room. Credit:Paul Jeffers

But Premier Daniel Andrews again refused to budge on the issue, which could play a key role in the battle with the Greens for the seat of Richmond at next year's election.

Following a rally on Victoria Street on Sunday, Laura Turner spoke of the death of her sister Skye, who died from a heroin overdose in March 2017. "She lay dead in the back of a van on Elizabeth Street in the CBD, that beautiful face, that incredible mind, had slipped away," she said.