Jimmy Kimmel, unexpected guardian of healthcare, has issued his latest monologue on the Cassidy-Graham bill, attacking President Trump and the Republican party for the third night straight.

The talk show host ignited an argument with one of the bill's creators, Louisiana senator Bill Cassidy, earlier in the week, but on Thursday night channelled his disbelief largely at the president.

"For Donald Trump, this isn’t about the Graham-Cassidy bill, it’s about getting rid of Obamacare, which he hates — primarily because Obama’s name is on it," Kimmel said.

"He likes to have his name on things, buildings, boxes. And, at this point, he’d sign anything if it meant getting rid of Obamacare. He’d sign copies of the Qur’an at the Barnes & Nobel in Fallujah if it meant he could get rid of Obamacare."

Many have speculated that Trump doesn't particular care about healthcare legislation but is simply looking for a win in Congress, and Kimmel echoed this.

"I guarantee [Trump] doesn’t know anything about this Graham-Cassidy bill," he declared. "He doesn’t know the difference between Medicare and Medicaid. He barely knows the difference between Melania and Ivanka!"

After Kimmel's initial healthcare comments made headlines, some questioned his political acumen - something the host addressed head-on Thursday night.

"I see these comments from these angry people, that say 'what qualifies you to talk about this stuff, you’re a comedian — go back to being not funny.'"

"And I feel like it’s my duty to remind these people who are so concerned about my qualifications — the guy you voted for President — his job qualification? Was this! He fired Meatloaf. And you put him in the White House."