ORIGINAL ARTICLE REDD1 (regulated in development and DNA damage 1) prevents dermal adipocyte differentiation and is required for hair cycle-dependent dermal adipose expansion FREE

In studies in mice that lack regulated development of DNA damage responses 1 (REDD1), a negative regulator of mTOR/protein kinase B, Rivera-Gonzalez et al. reveal that this factor regulates adipogenesis via induced expansion of dermal white adipose tissue through hypertrophy and hyperplasia, highlighting the possibility for therapeutic approaches to target skin-associated adipose tissue. .

ORIGINAL ARTICLE Flotillin and AP2A1/2 promote insulin-like growth factor receptor-1 association with clathrin and internalization in primary human keratinocytes FREE

Dam et al. provide evidence to support a mechanism by which IGF1R, which is integral to keratinocyte proliferation, migration, and survival, associates with flotillin-1 and clathrin in keratinocytes for internalization and rapid recycling via an endocytosis mechanism that is complementary to the classical AP2 complex pathway.

ORIGINAL ARTICLE A Randomized Placebo Controlled Trial of Secukinumab on Aortic Vascular Inflammation in Moderate to Severe Plaque Psoriasis (VIP-S) FREE

Although chronic inflammation in psoriasis has been linked to increased risk for cardiovascular disease, Gelfand et al. report that treatment of moderate-to-severe psoriasis with the efficacious IL-17A inhibitor secukinumab does not induce any change in aortic vascular inflammation or biomarkers of cardiometabolic disease. To learn more about the techniques used in this paper, visit this Research Techniques Made Simple article

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