Tom Castles

Image courtesy of King's College, London, UK

About 65% of patients with schizophrenia experience verbal auditory hallucinations, which are characterized by harsh voices that emanate from body-less “others.” Usually, these “others” fit a common profile – they're domineering, derogatory and unremittingly hostile, making an already-burdensome condition even more painful for those who suffer from it.Current treatments for schizophrenia like psychosocial therapy and antipsychotic medications help to ease hallucinations in many patients, but for roughly a quarter of people with psychotic conditions, available treatments just aren’t enough. What’s worse, many antipsychotic medications can lead over time to serious side effects like Parkinson disease and tardive dyskinesia, 2 debilitating movement disorders.But a new therapy moving through the clinical trial pipeline could provide hope for patients who aren’t getting the results they need from conventional therapies, and so far, it hasn’t shown any adverse safety events. It’s called AVATAR therapy, an aptly-named acronym that stands for Audio Visual Assisted Therapy Aid for Refractory auditory hallucinations.>> READ: Beyeonics Raises $11.5M to Develop AR and VR for Eye Surgeons AVATAR therapy first garnered attention when it was pilot tested as a treatment for patients with auditory hallucinations between 2009 and 2011 by the UK’s National Institute for Health Research. The hypothesis driving the therapy is novel, but based on an old cliché: face your fears. Study authors hypothesized that if patients could confront the voice in their heads by virtually personifying it through a software program and challenging their punitive and domineering tendencies, the patient could either overcome the voice, learn to live with it, or eliminate it entirely.In AVATAR therapy, patients build a customizable visual representation of the voice in their heads, known as the “persecutor.” The avatar has an appearance and tone of speech that closely matches the pitch and tone of the hallucinated persecutory voice. Suddenly, the hallucination enters the realm of reality.Patients are then encouraged to engage in a dialogue with the avatar, who is remotely controlled by a therapist. Rather than propagating a relationship where the persecutory voice dominates a submissive patient, the therapist controls the avatar so that slowly, over time, it yields control to the patient.>> Get the best insights in healthcare analyticsResults of the pilot study were encouraging. Patients who underwent the novel AVATAR therapy showed mean reductions in total Psychotic Symptom Rating Scale (PSYRATS) auditory hallucinations of 8.75 (P = .003), and in the Omnipotence and Malevolence subscales of the Revised Beliefs About Voices Questionnaire (BAVQ-R) of 5.88 (P = .004). On the other hand, the control group experienced no changes during the study period.Researchers behind a recent follow up study published in The Lancet set out to recreate those results in a larger, powered, randomized controlled trial, and again found that patients experienced favorable outcomes, with 83% meeting the primary end point – a reduction in auditory verbal hallucinations at 12 weeks.The study’s lead author Tom K J Craig, PhD, FRCP, emeritus professor of social psychiatry at King’s College London (pictured), was surprised by the study’s positive results. But he said the evidence was compelling, and that he was most impressed by the number of patients who clearly improved with therapy.“Most dramatic were the people for whom voices stopped entirely. Although Julian Leff had found this in his first pilot work, we did not really expect to see it repeated in our larger [powered, randomized] controlled study,” Craig told MD Magazine, a sister publication of Healthcare Analytics News™. “While that was the most striking outcome, the wider reductions in frequency and severity of voices reported by many people was also striking.”In the follow up study, Craig and colleagues described the significance behind the transition of power from persecutor to patient.“The operation of power within this relationship is viewed as crucial…the voice-hearer assum[es] a submissive role characterized by feelings of inferiority and powerlessness that can reflect social relationships more generally,” researchers wrote. “The therapist (switching between speaking as therapist and as avatar) facilitates a dialogue in which the voice-hearer gradually gains increased power and control within the relationship, with the initially omnipotent voice loosening its grip over the hearer by becoming more conciliatory over time."The results are especially encouraging because the trial involved a sample of people suffering from persistent psychoses who reported unremitting and distressing auditory hallucinations for at least the previous year, despite regular supervision and continuing pharmacological treatment. Moreover, more than a third of all patients across both therapy groups had a clinical record of treatment resistance and were prescribed clozapine before the start of the study.In the follow-up study, the reduction in PSYRATS total score at 12 weeks was significantly greater for AVATAR therapy than for supportive counseling, with a mean difference of -3.82 [SE 1.47], 95% CI -6.70 to -0.94; (P