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"I think it would be pretty odd for members on the other side of the aisle who almost unanimously supported the Iranian nuclear agreement ... [to] deny a weapons sale to somebody who is in the fight with you," Graham said from the Senate floor.

"You're talking about ass-backwards."

The Senate is expected to vote Wednesday afternoon on a resolution of disapproval that would block a $1.15 billion sale of tanks and related military equipment.

Graham argued the push is misguided given the current fight against the Islamic State in Iraq and Syria (ISIS) and recent ballistic missile tests by Iran.

"Saudi Arabia shared intelligence that's made Americans safe. They have allowed us to use their air bases in time of conflict," he said. "They are all-in against [ISIS]."

The vote also comes as the Senate expects to take a veto override vote on legislation that would allow families of victims of the Sept. 11, 2001, terrorist attacks to sue Saudi Arabia in U.S. courts.