Eight senior figures from the Islamic State (IS) were killed in an airstrike while meeting in a town in western Iraq, but the group's reclusive leader Abu Bakr al-Baghdadi did not appear to be among them, residents of the town and hospital sources said.

Iraq said on Sunday its air force hit the meeting and also struck a convoy that was carrying Baghdadi to attend it. It said Baghdadi had been driven away from the convoy in an unknown condition.

The Iraqi military's announcement was the latest unconfirmed report of the possible death or injury of Baghdadi, who has survived a year of US-led air strikes and multi-sided wars in two countries since proclaiming himself caliph of all Muslims after his forces swept through most of northern Iraq last year.

A Twitter account that publishes IS statements said "rumors" that an airstrike had targeted Baghdadi were false.

The United States military declined to comment on the Iraqi military's report.

"Iraqi air forces have bombed the convoy of the terrorist Abu Bakr al-Baghdadi while he was heading to Karabla to attend a meeting with Daesh commanders," the Iraqi military said in a statement, using the Arabic acronym for IS.

Karabla is a town in Iraq's Anbar province near the Syrian border, an IS stronghold, not to be confused with Kerbala, a Shiite holy city in the south.

"The location of the meeting was also bombed and many of the group's leaders were killed and wounded. The fate of murderer al-Baghdadi is unknown and he was carried away by a vehicle. His health condition is still unclear," the Iraqi military said.

Hospital sources and residents said airstrikes hit two houses and killed eight senior local leaders of an IS police force in the town.

IS supporters said on Twitter that even if Baghdadi had been killed, his self-proclaimed caliphate straddling large areas of Iraq and Syria would survive.

"Do you think we would leave the State of the caliphate and abandon it, oh vile world?," asked one of his followers. "This is the religion of God, it rose on the skulls of heroes and martyrs and every time one of them is martyred we rise."

Baghdadi has galvanized militants from around the world, encouraged by his military successes and plans to redraw the map of the Middle East to create a self-sustaining caliphate.

His successes prompted the United States to re-engage in Iraq with airstrikes against his fighters three years after pulling out following a long, costly occupation.

Russia, which has launched a bombing campaign to aid its Syrian ally Bashar al-Assad, says the militant group is its main enemy as well.

An IS fighter reached by telephone could not confirm to Reuters whether Baghdadi had been in a convoy that was struck, but said the group would fight on whatever his fate.

"Even if he was martyred then it will not affect Islamic State," he said. "We will lose a leader but there are a thousand Baghdadis."

Baghdadi has survived multiple previous airstrikes that were rumored to have killed him over the past year, though reports in April suggested he was seriously wounded and no longer in full control of the group. The US has put a $10 million bounty on his head.