Gov. Janet Napolitano is President-elect Barack Obama's top choice to lead the department of Homeland Security, CNN is reporting.

Napolitano, according to reports airing this evening, has indicated she would accept the Cabinet post. The Governor's Office is not confirming the CNN report, but is not denying it, either.

When asked whether the governor has been offered the Homeland Security post, or whether she has indicated she would accept it, Napolitano spokeswoman Jeanine L'Ecuyer said repeatedly, "I can't answer that."

A two-term governor and early Obama supporter, Napolitano has been the focus of Cabinet speculation for weeks. But she has always turned aside questions about her interest in joining the new administration.

She did the same Wednesday morning, telling reporters she is focused on her state duties and isn't seeking a new job.

If Napolitano does, in fact, depart Arizona for a post in Washington, D.C., it would create a sizable shakeup in state government.

Republican Secretary of State Jan Brewer would serve the remaining two years of Napolitano's term, as next-in-line to the governorship. Brewer, a former state legislator, would appoint a replacement for secretary of state.