Brett Ratner, a top producer and director whose films include “Rush Hour” and “The Revenant,’’ is facing allegations from women who said he had sexually harassed or assaulted them over the course of two decades, making him the latest prominent Hollywood figure to be accused of sexual misconduct.

In an article published Wednesday in The Los Angeles Times, six women described encounters with Mr. Ratner that ranged from lewd comments to assault.

One actress, Natasha Henstridge, who has appeared in films including the “Species” series and “The Whole Nine Yards,” said that Mr. Ratner had forced her to perform oral sex more than 20 years ago. Another, Olivia Munn, said Mr. Ratner had masturbated in front of her when, as an aspiring actress, she delivered food to his trailer.

Late Wednesday, Mr. Ratner issued a statement saying that “in light of the allegations being made’’ he was stepping away from all activities related to Warner Bros., the movie studio with which he has a $450 million agreement to cofinance films.