A Crime Stoppers caller has reportedly claimed Karlie Pearce-Stevenson was a drug runner who had up to $25,000 in debt.

Police have been told Ms Pearce-Stevenson may have been pursued for the $25,000 of drug debt in the months leading up to her death, the Adelaide Advertiser reports.

The informant reportedly claimed Ms Pearce-Stevenson allegedly fled Alice Springs with her daughter Khandalyce Pearce and the $25,000 in cash which was supposed to be used to buy drugs which were then to be smuggled interstate.

However, she never purchased the drugs.

Khandalyce Pearce. (Supplied)

The informant also reportedly told police Ms Pearce-Stevenson’s grandmother was charged with serious drug offences in 2008.

Ms Pearce-Stevenson reportedly lived with her grandmother as a teenager and shortly before she disappeared.

The informant also claimed Ms Pearce-Stevenson was heavily involved with Daniel Holdom, the man charged with her murder.

Daniel Holdom. (Supplied)

Police allege Ms Pearce-Stevenson was killed in December of 2008 after which her mobile phone was used to contact her family and provide false proof of life.

It is alleged her bank accounts were accessed and her Centrelink benefits taken for a number of years.