http://www1.play.it/audio/gamertag-radio/episode-626/



Two major things:

1. El Sueno (the main boss) and his four “executives” will not be available to find and kill at the beginning of the game.

2. Guns are not purely aesthetic! If you stow them away you will appear less threatening to NPCs. This still does not apply to clothing, however. It was last confirmed that clothing is still purely aesthetic.