Tonight, after 340 days in space, seasoned astronaut Scott Kelly will fly home from orbit inside a Soyuz spacecraft.

By all accounts, Kelly has had a sterling turn of work aboard the station during the last 11-plus months, with his health holding steady and his meeting of virtually every milestone NASA has placed before him. Now he will come home for more extensive medical tests to help NASA determine the effects of long-duration spaceflight on the human body.

According to the flight schedule, Kelly and Russian cosmonauts Mikhail Kornienko and Sergey Volkov will undock from the International Space Station tonight at about 8pm ET. After maneuvering away from the space station, they will be in position to begin their de-orbit burn about two hours and 30 minutes later.

Tonight's liveblog will therefore commence at 10:30pm ET (03:30am GMT) and continue through about midnight ET. Landing is scheduled for 11:25pm ET. Join us to track the landing and discuss the significance of Kelly's journey—what it may (or may not) mean for the agency's efforts to send humans back beyond low-Earth orbit for the first time in more than four decades.