A man injured in an explosion Tuesday at a south Edmonton home ran screaming from the house with his clothes burned off, say neighbours.

"He looked like his skin, face, arms, front, legs are really red; no clothes; burned right off," said Feroza Anthony, who lives next door.

Anthony said she ran out of her home when she heard the blast and shattering glass. She said she briefly smelled a chemical or gas odour before calling 911.

The man who owned the home came outside and told them everything is OK, she said.

He then took the injured man to hospital, she said.

Firefighters arrived at the home at 58th Street and 18th Avenue SW around 5:30 p.m. Tuesday.

Police and firefighters continue to investigate the blast Wednesday. (CBC) They called police to the scene a short time later.

Anthony said she and her husband have known the two men who live in the home for more than four years and had never had any problems with them..

A neighbour who lives across the street said his wife saw the injured man running from the house.

Police are not saying what caused the explosion or if they think it is criminal in nature.

On Tuesday night they said two men were in hospital with serious, but non-life-threatening, injuries.