Citation Jørgensen, Søren Peter, et al. "Active Crohn's Disease Is Associated With Low Vitamin D Levels." Journal of Crohn's & Colitis, vol. 7, no. 10, 2013, pp. e407-13. Jørgensen SP, Hvas CL, Agnholt J, et al. Active Crohn's disease is associated with low vitamin D levels. J Crohns Colitis. 2013;7(10):e407-13. Jørgensen, S. P., Hvas, C. L., Agnholt, J., Christensen, L. A., Heickendorff, L., & Dahlerup, J. F. (2013). Active Crohn's disease is associated with low vitamin D levels. Journal of Crohn's & Colitis, 7(10), e407-13. https://doi.org/10.1016/j.crohns.2013.01.012 Jørgensen SP, et al. Active Crohn's Disease Is Associated With Low Vitamin D Levels. J Crohns Colitis. 2013;7(10):e407-13. PubMed PMID: 23403039.

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TY - JOUR T1 - Active Crohn's disease is associated with low vitamin D levels. AU - Jørgensen,Søren Peter, AU - Hvas,Christian Lodberg, AU - Agnholt,Jørgen, AU - Christensen,Lisbet Ambrosius, AU - Heickendorff,Lene, AU - Dahlerup,Jens Frederik, Y1 - 2013/02/09/ PY - 2012/08/24/received PY - 2012/12/13/revised PY - 2013/01/14/accepted PY - 2013/2/14/entrez PY - 2013/2/14/pubmed PY - 2014/5/17/medline KW - (TGF)-β KW - 1,25(OH)(2)D KW - 1,25-(OH)(2) vitamin D KW - 25-OH vitamin D KW - 25OHD KW - C-reactive protein KW - CD KW - CDAI KW - CRP KW - Crohn's disease KW - Crohn's disease activity index KW - INF-γ KW - Smoking KW - TNF-α KW - VDR KW - Vitamin D KW - interferon gamma KW - transforming growth factor KW - tumour necrosis factor alpha KW - vitamin D receptor SP - e407 EP - 13 JF - Journal of Crohn's & colitis JO - J Crohns Colitis VL - 7 IS - 10 N2 - BACKGROUND AND AIMS: Crohn's disease prevalence increases with increasing latitude. Because most vitamin D comes from sunlight exposure and murine models of intestinal inflammation have demonstrated beneficial effects of 1,25-(OH)2 vitamin D treatment, we hypothesised that Crohn's disease activity is associated with low vitamin D levels. METHODS: In a cross-sectional study of 182 CD patients and 62 healthy controls, we measured serum 25-OH vitamin D. Stratified analysis was used to compare 25-OH vitamin D levels with Crohn's disease activity index, C-reactive protein, smoking status, intake of oral vitamin D supplements and seasonal variation in CD patients and healthy controls. RESULTS: Serum 25-OH vitamin D was inversely associated with disease activity: Median 25-OH vitamin D levels of Crohn's disease in remission, mildly, and moderately active diseases evaluated by Crohn's disease activity index were 64, 49, and 21 nmol/l (p<0.01) and by CRP 68, 76, and 35 nmol/l (p<0.05), respectively. Patients who took oral vitamin D supplementation had lower Crohn's disease activity index (p<0.05) and C-reactive protein (p=0.07) than non-users. Crohn's disease patients who smoked had lower vitamin D levels (51 nmol/l) than patients who did not smoke (76 nmol/l), p<0.01. Overall, Crohn's disease patients did not differ from healthy controls regarding 25-OH vitamin D levels. CONCLUSIONS: Active Crohn's disease was associated with low serum 25-OH vitamin D. Patients who smoked had lower 25-OH vitamin D levels than patients who did not smoke, independently of disease activity. SN - 1876-4479 UR - https://www.unboundmedicine.com/medline/citation/23403039/Active_Crohn's_disease_is_associated_with_low_vitamin_D_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1873-9946(13)00032-9 DB - PRIME DP - Unbound Medicine ER -