A 27-year-old man shot in Winston Hills last night was home with his mother in a crime police have described as gang-related.

Parramatta police commander Supt Robert Redfern told media this afternoon that the man was shot in the left arm and left leg in the front room of the house in Reilleys Rd at about 11.15pm.

Supt Redfern said the man lived in the house with his 53-year-old mother, who was slightly injured by shattered glass.

Known to police, the man was recovering in Westmead Hospital but had not told police much about the shooting.

"But we hope to speak to him again when he recovers from his treatment," Supt Redfern said.

"It seems the shooting was targeted but that does not make it acceptable and we will use all our resources to find those responsible."

Supt Redfern said "several shots" had been fired into the front window of the house after there had been a knock at the door.

It seems the victim left the house and sought help from a neighbour. He was treated at the scene by ambulance paramedics before being taken to hospital where he remains in a stable condition.

Supt Redfern would not say how the victim was known to police, but said the shooting was likely gang related, although he would not say if that meant there were bikie gang involvement.

"it is early days in the investigation and we urge anyone with any information to report it to Crime Stoppers on 1800 333 000.

There is a description of two suspects, although Supt Redfern would not say if witnesses were neighbours.

"We are looking for two men of Middle Eastern appearance, both aged 20-25 years - one short and of solid build, wearing black clothing and a black hoodie and the other one is described of standard height and build, wearing dark clothing."