Kevin Meaney, a headliner on the stand-up comedy circuit for more than 30 years, was found dead on Friday at his home in Forestburgh, N.Y. He was 60.

Mr. Meaney’s former wife, Mary Ann Halford, confirmed his death. She said the cause was not yet known.

Mr. Meaney made numerous appearances on late-night television talk shows, including more than a dozen on “The Tonight Show Starring Johnny Carson” beginning in 1987, a year after his first HBO special, according to his website.

He played the title role, an irresponsible slob saddled with raising his brother’s three children, on “Uncle Buck,” a CBS sitcom based on the John Candy movie of the same name. The show lasted only one season (a 2016 version, starring Mike Epps, had an even shorter run), but Mr. Meaney was seen frequently on television after it was canceled in 1991.