Updated Amnestics Guide

Proposal for the Classification of Synthetic, Non-Anomalous Amnestic Agents

Foreword

Both the Foundation and its predecessor organizations have relied on memory affecting agents in order to expunge sensitive data from the minds of unauthorized individuals. Though we have generally classified such agents under the umbrella term ‘amnestics’ (and less accurately, amnesiacs), we have, in fact, used a wide variety of different agents to accomplish this task.

Many of our commonly used amnestics are themselves anomalous, either in origin or mechanism. The fact that amnestics are frequently anomalies themselves effectively renders them Thaumiel class SCPs, recklessly handed out to any MTF, Field Agent, or Researcher who wants them. Furthermore, the collection of these amnestics are often either fraught with danger or are otherwise ethically problematic.

Fortunately, neuroscience has advanced significantly since the Foundation was founded, and we now have the means to mass produce non-anomalous amnestic drugs. In addition to being wholly non-anomalous, the next generation of amnestic drugs is expected to be more cost-effective for the Foundation and boast a better safety profile for their subjects. These drugs function primarily by inducing memory deconsolidation, breaking down the neural pathways responsible for encoding episodic memories. The drugs themselves are encased within specially designed nanoparticles, allowing for the targeting of specific areas of the brain, drastically reducing the amount of drug required as well as side effects.

The O5 Council is currently reviewing proposals to gradually phase out the use of traditional amnestics and replace them with non-anomalous alternatives. In order to facilitate this transition among Foundation personnel, we submit the following revisions to the current amnestics classification system. Please note that all classes of amnestics are now available in oral, inhalant, and intravenous forms for the convenience of amnestics officers, and still retain the taste of batteries and peppermint that none of us can remember but always find familiar.

Class A, General Retrograde

For erasing recent and/or specific episodic memories

While Class-A amnestics will technically deconsolidate memories at random, they will mostly affect engrams within the ‘memory reconsolidation window’ of 5-6 hours, as these are the memories that will be at the forefront of the subject’s mind. This is especially true for highly unique episodic memories, such as encounters with anomalous phenomena. While these will be most effective after initial exposure, it is possible to re-open a memory reconsolidation window, allowing for amnestics officers to trigger and then erase specific memories long after their initial formation.

Class B, Regressive Retrograde

For the incremental erasure of recent memories

Class B amnestics start by deconsolidating the most recently formed memories first, and then working their way backwards. The extent of the memory erasure is dependent on dosage, with a 75 mg dose resulting in approximately 24 hours of memory loss on average. These are ideal for erasing recent memories older than six hours without having to trigger specific memories.

Class C, Targeted Retrograde

For the removal of specific memories from any point in the subject's life

Class C amnestics are used in conjunction with high fidelity neuro-imaging and transcranial stimulation. Neuro-imagers will locate the specific memory engrams within the subject’s brain, and upon reaching those specific engrams the amnestics will be activated through the use of precise, non-invasive stimulation, typically ultrasound or magnetic fields.

The benefit of Class C amnestics is that they allow for the surgically precise removal of memories regardless of when they formed, and are ideal for expunging classified data from the minds of D-class personnel and neutralized humanoid SCPs prior to their release. The major drawback of Class C amnestics is the required equipment’s lack of portability. As such, Class C amnestics are most efficiently administered at Foundation sites, though mobile amnestic field clinics are currently under development.

Class D, Progressive Retrograde

For the removal of early memories

Class D amnestics are the opposite of Class Bs. They target the oldest memories first and work their way forward, the effects depending on dosage. As this is a fairly niche application, Class D amnestics are rarely used. Though they are, by design, more potent than their counterparts, it still requires an extremely high dosage to expunge a significant portion of a subject’s life. As such, their risk of side effects is dangerously high. It should be noted that Class D amnestics only target explicit memories. Implicit memories, namely skills that the individual learned in their youth, will remain unaffected.

Class E, Ennui

To induce psychological complacency with the anomalous

To be frank, ‘ennui’ isn’t actually the proper term for the psychological effects of Class E amnestics. They would more accurately be considered an ‘anti-nostalgia’ drug. Though they still target the neural pathways for memories, they do not deconsolidate them. Rather, they merely weaken the pathways while disassociating the memory with any emotions, positive or negative, removing any incentive to think about it and thus allowing it to naturally decay on its own.

Class E amnestics are most effective in situations where the suppression of the anomalous is not possible, and thus in order to preserve normality, the anomaly must be perceived as normal. Class E amnestics cause subjects to accept the world as it is, and forget that it was ever any different.

Class F, Fugue

For erasing and rebuilding the subject's identity

As with the old Class F, these amnestics induce a Fugue State, or dissociative amnesia, in the subject. The subject will forget their identity and may either be provided with a new one by the amnestics officer, or allowed to develop one on their own.

Class G, Gaslighting

To cause subjects to doubt the authenticity of their memories

Class G amnestics induce derealisation of memories, making them seem fantastic or dreamlike, causing the subject to doubt their authenticity. Standard field Class-G amnestics are formulated to target memories of the anomalous, and are best administered when the subject lacks any tangible evidence of their account and targeting specific memories is infeasible. Class-G amnestics that target non-anomalous memories, however, have been banned by the Ethics Committee are currently under development at the request of the O5 Council.

Class H, Anterograde

To prevent the formation of new memories

Class H amnestics prevent the subject from forming new memories, blocking memory consolidation for as long as the agent is in the subject’s system. Duration is dependent on dosage, with 75 mg lasting for approximately 24 hours on average.

Class I, Transient

For inducing a temporary amnesic state

Class I amnestics induce transient amnesia by blocking the neural pathways responsible for long-term memories, temporarily preventing subjects from recalling their past. Duration is dependent on dosage, again with 75 mg lasting approximately 24 hours on average.

Class W-Z, Mnestics

Protection against anti-memetic and other mnemonic anomalies

Classes W-Z refer to mnestic drugs, or drugs that prevent/reverse memory erasure, and are most commonly used by the antimemetics department. Though in function they are the opposite of amnestics, they both work by targeting the neural pathways for memory, allowing for the creation of non-anomalous mnestic drugs.

Class W mnestics allow the subject to perceive and retain knowledge of antimemes, in addition to general memory enhancement. Class X restores awareness of previously perceived antimemes or suppressed memories. Class Y grants the subject perfect recall for any memories gained during its period of effect, and a single dose of Class Z renders the subject biochemically incapable of forgetting anything for the remainder of their lives. Class Zs are invariably fatal, with death by seizure typically resulting in a matter of hours.

Combining amnestic and mnestic drugs is not recommended.

Report to Overseer Council Regarding the Ethics of Non-Anomalous Amnestics