For the first time in many weeks, Denver is not the biggest favorite on the board.

The Week 7 honor of being the biggest chalk goes to Green Bay, which opened as 11.5-point favorites to visiting Cleveland.

Still, the Broncos were laying six points as they head to Indianapolis for Peyton Manning's return. It's a game that sees number solid trends favoring Colts bettors, including the 5-0 ATS run against the Broncos and the 7-0 ATS run in their last seven games as home underdogs.

Seattle opened as 7-point chalk at Arizona, but the Cardinals have owned the Seahawks in recent years (7-1 SU and ATS). That game goes Thursday as the Cards try to avoid their eighth straight division loss.

San Diego, which ground out a Monday Night win over the Colts, lay nine points at Jacksonville. All five career meetings have played OVER and the Chargers have played OVER in 13 of the past 14 seasons before a bye week.

Six teams are headed to their bye weeks, forcing NFL bettors to focus on bye week angles in Week 7. Opening numbers courtesy of 5Dimes.eu.

Seattle -7 at Arizona +7, Total 40 - Matchup Report



Trends: The total has gone OVER in 8 of Seattle's last 9 games when playing on the road against Arizona

The total has gone OVER in 8 of Arizona's last 9 games when playing at home against Seattle

Chicago PK at Washington PK, Total 51 - Matchup Report



Trends: The total has gone OVER in 8 of Chicago's last 9 games on the road

Washington is 6-1 SU in its last 7 games when playing at home against Chicago

San Diego -9 at Jacksonville +9, Total 45.5 - Matchup Report



Trends: The total has gone OVER in 5 of San Diego's last 5 games when playing Jacksonville

The total has gone UNDER in 5 of Jacksonville's last 5 games at home

Buffalo +7.5 at Miami -7.5, 41 - Matchup Report



Trends: The total has gone UNDER in 6 of Buffalo's last 7 games when playing on the road against Miami

The total has gone UNDER in 6 of Miami's last 7 games when playing at home against Buffalo

Tampa Bay +9 at Atlanta -9, Total 42.5 - Matchup Report



Trends: The total has gone UNDER in 8 of Tampa Bay's last 9 games

The total has gone OVER in 5 of Atlanta's last 5 games at home

New England -3.5 at NY Jets +3.5, Total 43.5 - Matchup Report



Trends: New England is 5-0 SU in their last 5 games when playing NY Jets

The total has gone OVER in 7 of the NY Jets last 8 games when playing New England

St. Louis +6 at Carolina -6, Total 42 - Matchup Report



Trends: The total has gone OVER in 5 of St. Louis's last 6 games

Carolina is 4-1 SU in its last 5 games when playing St. Louis

Dallas +2.5 at Philadelphia -2.5, Total 56.5 - Matchup Report



Trends: The total has gone UNDER in 10 of Dallas's last 13 games on the road

The total has gone OVER in 8 of Philadelphia's last 9 games

Cincinnati +2.5 at Detroit -2.5, Total 47 - Matchup Report



Trends: Cincinnati is 7-1 SU in its last 8 games when playing Detroit

The total has gone OVER in 5 of Detroit's last 6 games at home

San Francisco -4.5 at Tennessee +4.5, Total 39.5 - Matchup Report



Trends: The total has gone OVER in 4 of San Francisco's last 5 games on the road

Tennessee is 6-0-1 ATS in its last 7 games when playing San Francisco

Houston +7.5 at Kansas City -7.5, Total 40 - Matchup Report



Trends: The total has gone OVER in 5 of Houston's last 7 games

Kansas City is 5-0 SU in its last 5 games

Cleveland +11.5 at Green Bay -11.5, Total 46 - Matchup Report



Trends: The total has gone UNDER in 5 of Cleveland's last 7 games on the road

Green Bay is 5-0 SU in its last 5 games at home

Baltimore +1 at Pittsburgh -1, Total 40.5 - Matchup Report



Trends: The total has gone UNDER in 4 of Baltimore's last 5 games

The total has gone UNDER in 11 of Pittsburgh's last 13 games at home

Denver -7 at Indianapolis +7, Total 55.5 - Matchup Report



Trends: Denver is 5-0 SU in its last 5 games

Indianapolis is 5-0 SU in its last 5 games when playing Denver

Minnesota +3.5 at NY Giants -3.5, Total 46.5 - Matchup Report



Trends: The total has gone OVER in 5 of Minnesota's last 5 games

The total has gone OVER in 4 of the NY Giants last 5 games at home