A man and a woman were shot Sunday evening when multiple rounds of gunfire - including from police - rang out in a south Huntsville neighborhood.

The shooting occurred around 6 p.m. at a home in the 2500 block of Bonnie Oaks Drive. Lt. Darryl Lawson, a spokesman for the Huntsville Police Department, said that the couple was estranged and that the woman had been living at the home with her mother.

The man, whose name is being withheld by police, broke into the rear of the house armed with a gun, Lawson said. At that time, the woman told her mother to run away and call police.

While the homeowner ran to a neighbor's house, calling 911 and tripping the house's burglar alarm, her daughter armed herself with a shotgun.

When the man did not stop coming toward her or drop his own weapon, she shot him, Lawson said.

Police officers arriving at that moment heard gunshots and saw the woman in the garage, holding the shotgun. They demanded she drop the weapon, and when she turned toward them with the gun in her hand, at least one officer opened fire.

The woman was struck by the police gunfire. Both she and the man were taken to Huntsville Hospital.

Lawson said the woman's condition was listed as non-life-threatening. The man's condition is life-threatening.

As is typical in an officer-involved shooting, the officer who fired the shots will be placed on administrative leave as the department investigates the use of force, Lawson said.

Several neighbors heard the gunfire on the normally quiet street. Angela Humlicek, who lives across the street, said she heard a single shot and, when she went to see what the noise was, she helped the woman's mother to safety.

"She was on the phone with police and the alarm was going off," Humlicek said.

It was not immediately clear if the couple was married or in a dating relationship. Lawson said that the woman had taken at least one restraining order out for her own protection.

AL.com will update this story with more information as it comes in.

Updated from the scene at 8:25 p.m. with additional information.