(Reuters Health) - An increasing proportion of U.S. women are experiencing serious and potentially life-threatening complications while giving birth, government researchers report.

Between 2006 and 2015, rates of severe complications rose by 45 percent overall, according to a report released by the Agency for Healthcare Research and Quality’s Healthcare Cost and Utilization Project (HCUP).

The researchers found that rates of kidney failure, shock, sepsis and ventilator use more than doubled during the 10-year period. Blood transfusions, an indicator of hemorrhage, increased by 54 percent.

Moreover, the highest rates of severe complications occurred in mothers over age 40, as well as those who lived in large urban areas or were poor, uninsured, or on Medicaid. Black and Hispanic women were also more likely to experience severe complications compared with white women.

The increasing complication rate “is an urgent public health issue in this country despite what people might want to believe,” said study coauthor, Megan Hambrick, a program analyst with the Agency for Healthcare Research and Quality. “Our study also highlights significant racial and ethnic disparities.”

The HCUP databases come from hospital administrative data and include information on diagnoses and procedures, patient discharge status and patient demographics, as well as the hospitals’ charges.

During the 10-year period studied, severe complications rose from 101 per 10,000 deliveries to 147 per 10,000 deliveries. Blood transfusions, the most common complication, often occurred when patients had other serious complications, such as shock or hysterectomy.

Hambrick and her colleagues found that while deaths decreased overall, black women were three times as likely as white women to die when delivering a baby in 2015 – their mortality rate was 11 deaths per 100,000, compared with 4 deaths per 100,000 among white women.

Severe complications were also more likely in certain minorities. Black women were 110 percent more likely than whites to experience severe complications and Hispanic women were 40 percent more likely to experience severe complications compared with whites.

The data don’t offer an answer as to why complications are on the rise or why minorities are more at risk.

That’s something for future research, experts said.

“The statistics presented are certainly disturbing, and in line with all the recent publicity surrounding this problem around the country,” said Dr. Alan Peaceman, a high-risk obstetrician at Northwestern Medicine in Chicago, who wasn’t involved in the study. “It does not determine, however, the causes of the increase in severe maternal morbidity over the 10-year timespan. On the healthcare side, the rise in the rate of cesarean sections may be contributing to the increase in morbidity. Patient changes that could be factors including increasing rates of obesity and diabetes, older maternal age, and use of infertility treatments.”

The causes are most likely multifactorial, agreed Dr. Andrew Satin, the Dr. Dorothy Edwards Professor and director of gynecology and obstetrics at Johns Hopkins Medicine in Baltimore, Maryland.

“Older women are getting pregnant as well as women with preexisting conditions,” said Satin, who also was not involved in the report. “Obesity is clearly a contributor. And our use of cesarean delivery really contributed to this. When more women are having cesarean sections there’s more risk for hemorrhage. And repeat cesarean sections create more risk for hemorrhage.”

As for the increased risk of hysterectomy, that may also be related to C-sections, Satin said. When women have C-sections, they can develop scar tissue, which can cause the placenta to adhere to the uterus, he said. “In a normal delivery, the placenta naturally separates from the uterine wall, he explained. “When there is scar tissue sometimes the placenta doesn’t come out or it comes out in pieces. That can lead to hemorrhage, at which point a hysterectomy can be life-saving.”

The situation can be improved with the implementation of safety packages and guidelines and with greater access to care for pregnant women, Satin said. Hospital staff need to be prepared for emergencies, he added. For example, “you should have a hemorrhage cart that’s stocked with the devices and medications commonly used,” Satin said. “And there should be a team that’s used to dealing with massive hemorrhages. And a checklist on the wall, so nobody forgets what to do.”

The fact that other countries have lower rates of maternal complications means that the situation can be improved, Satin said. “I believe we can do better and we should do better.”

SOURCE: bit.ly/2wNZ5db Agency for Healthcare Research and Quality HCUP Statistical Brief number 243, September 2018.