Invention is a process for development of scaffold from plant tissues for application in skin tissue engineering. Its a method to prepare plant-derived artificial skin which closely resembles skin micro-environment. Skin tissue engineering involves remodeling of native skin for various applications. The main limitations being immune rejection, slow healing, pain, scarring and infection. Also, various ethical issues arise on usage of animals for skin testing experiments. Our plant-derived artificial skin can be utilized as a substitute for animal testing, in wound healing and in high throughput screening of drugs and cosmetics .