A man has been charged with two counts of manslaughter after allegedly losing control of his speeding BMW on a major Brisbane road and causing a seven-vehicle crash that killed two people.

Witnesses estimated 37-year-old Michael James Smith was speeding up to 150 kilometres per hour before the crash late on Saturday night and was, at times, on the wrong side of the road before the alleged hit-and-runs, the Brisbane Magistrates Court heard.

Police alleged Mr Smith first collided with a moped that was travelling in the same direction on Lutwyche Road at Windsor, killing its 32-year-old male driver.

Mr Smith is accused of then veering into the southbound lanes to became airborne, colliding with a Subaru driven by a 23-year-old Acacia Ridge man, and then a Jeep.

The drivers of the moped and the Subaru died at the scene.

Three other cars travelling on Lutwyche Road also sustained minor damage.

'Shocking' traffic history

Police alleged the BMW finally came to rest on its roof and its driver, with Mr Smith and one of his passengers allegedly fleeing.

Another passenger, a 24-year-old Aspley woman, was seriously injured and taken to hospital.

Mr Smith was charged with two counts of manslaughter and one of dangerous driving causing grievous bodily harm, excessive speed, and failing to remain at the scene.

The drivers of the moped and the Subaru died at the scene. ( ABC News )

He applied for bail in the Brisbane Magistrates Court but it was refused and the case was adjourned until next month.

The police prosecutor opposed bail, describing Mr Smith's traffic history — which was said to have included unlicensed and disqualified driving — as "shocking".

Defence lawyer Nick Dore told the court his client had surrendered himself to police this morning and his family was prepared to pay a surety of up to $30,000 if he was to be released on bail.

When asked by the magistrate about his client allegedly fleeing the scene of the crash, Mr Dore said people could "do silly things" when in a state of panic.