NFL Nation reporters assess the biggest injuries across the league for Week 2.

AFC East | AFC North| AFC South | AFC West

NFC East | NFC North | NFC South | NFC West

AFC EAST

The Bills listed Sammy Watkins as questionable for Thursday's game against the Jets, but he insists his sore foot won't keep him out of action. If he can't play, the Bills are likely to use a mix of Greg Salas and Marquise Goodwin in his place. Left tackle Cordy Glenn is out because of an ankle injury, and 2014 second-round pick Cyrus Kouandjio will receive his third career start in Glenn's place. -- Mike Rodak

The Dolphins put starting defensive end Mario Williams, who didn't finish last week's game, in concussion protocol. Williams didn't practice Wednesday, and his status is in question for Sunday's game against New England. If Williams cannot play, Cameron Wake will get more reps in his place. Wake played just 29 snaps as a situational pass-rusher but would have to increase his workload with a shorter rotation at defensive end. -- James Walker

Linebacker Dont'a Hightower was not present at Wednesday's practice after he injured his knee on the second series of the opener. He played through the injury, but his status bears monitoring this week. Meanwhile, tight end Rob Gronkowski and left tackle Nate Solder, both of whom missed the season opener because of hamstring injuries, were limited participants in Wednesday's practice. Unless this changes in the next two days, it likely means they will be questionable for Sunday's home opener against the Dolphins. If Gronkowski doesn't play, the Patriots will once again rely on Martellus Bennett as the top tight end option; he played 69 of 71 offensive snaps in the season opener. -- Mike Reiss

The Jets are in good shape for Thursday night against the Bills. The only two notable injuries are defensive end Muhammad Wilkerson (ankle, toe) and linebacker David Harris (shoulder), both of whom are questionable. The team expects both to play, though Harris will be less than 100 percent, especially in a short week. The injury happened three weeks ago, and he's still undergoing treatment. He played every defensive snap in the opener. -- Rich Cimini

AFC NORTH

Wide receiver Breshad Perriman is on the injury list again. He's dealing with a minor calf issue, but it was enough to keep him sidelined Wednesday, and it could keep him out of Sunday's game against the Browns. Without Perriman, the Ravens would rely even more on Mike Wallace in the deep passing game. Linebacker Elvis Dumervil remains out with a foot injury, and it's unlikely he'll play. With backup Za'Darius Smith also sidelined by an ankle injury, Baltimore might look to rookie Matt Judon to be an outside edge rusher. -- Jamison Hensley

Tight end Tyler Eifert said Wednesday that he would miss Sunday's game against the Steelers. His ankle injury is still keeping him off the practice field. Cornerback Darqueze Dennard practiced fully for the first time, which indicates that he could return to the lineup Sunday. C.J. Uzomah, Eifert's replacement who had only one catch as a rookie, had a breakout game against the Jets, with a 54-yard pass reception. Dennard will likely man the slot upon his return. -- Katherine Terrell

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Josh McCown takes over for Robert Griffin III at quarterback with Griffin sidelined by a fracture in his shoulder. "I'm full speed ahead with Josh," coach Hue Jackson said. The only other injury of note was to backup safety Derrick Kindred, who was limited by an ankle on Wednesday. Kindred played well in relief of Ibraheim Campbell in the opener. -- Pat McManamon

Linebacker Ryan Shazier missed Wednesday's practice because of a knee injury, and though it isn't considered serious, his status for the Bengals game is in doubt. Shazier, fresh off an interception in Week 1, is pushing hard behind the scenes. He doesn't want to miss any time. -- Jeremy Fowler

AFC SOUTH

Besides inside linebacker Brian Cushing and left tackle Duane Brown, who will definitely not play Sunday against the Chiefs, the Texans are relatively healthy. Coach Bill O'Brien said Brown and Cushing are weeks away from returning. While Brown has been out, tackle Chris Clark has played in his place. He played every offensive snap Sunday and was solid against the Bears. After Cushing left Sunday's game early in the first quarter, Max Bullough filled in at inside linebacker and improved as the game went along, registering five combined tackles, including one for a loss. The Texans have depth at linebacker, including Akeem Dent and Brian Peters. -- Sarah Barshop

Outside linebacker Robert Mathis did not practice Wednesday because of a foot injury. He said on his weekly radio show on WNDE 1260 AM in Indianapolis that he has a hyperextended toe and is wearing a protective boot. The Colts can't afford to lose Mathis, who was held out of the preseason, because they had only one sack in their Week 1 loss to Detroit. Trent Cole, who had three sacks last season, will likely start if Mathis doesn't play. -- Mike Wells

Running back Chris Ivory was released from the hospital Tuesday, but the Jaguars aren't sure whether he'll be available for Sunday's game in San Diego. Ivory was hospitalized Sunday morning with what the team said was a "general medical issue." Ivory did not practice Wednesday, though he is expected to hold a news conference to address his injury at some point this week. If Ivory does not play against the Chargers -- and that's the way it's looking -- the Jaguars might give kick returner Corey Grant some reps on offense, in addition to Denard Robinson. Ivory is expected to return to the field at some point, but it looks like that will be next week at the earliest. -- Mike DiRocco

Outside linebacker Derrick Morgan (left hamstring) was out Wednesday, but coach Mike Mularkey left open the possibility that Morgan could practice Thursday, and that would give him a chance to play. If the Titans are without him, David Bass and two rookies -- Kevin Dodd and Aaron Wallace -- will combine to fill in, and Mularkey expects production. The Titans were thin behind Morgan and Brian Orakpo last season, which was a big reason they spent the first pick of the second round on Dodd. -- Paul Kuharsky

AFC WEST

All eyes are on wide receiver Demaryius Thomas, who is getting treatment on the left hip injury he suffered in the first quarter of the regular-season opener against the Panthers. Thomas was held out of Monday's practice, but he practiced on a limited basis Wednesday. Coach Gary Kubiak said Thomas took "about a third of the reps'' in Wednesday's practice. Kubiak added that Thomas "is on course to make it to Sunday.'' The Broncos could be helped by the fact that they played Thursday because that meant they could give Thomas treatment through the weekend. At Wednesday's practice, Thomas could be seen hitting his left hip after he ran at times. The Broncos have some depth issues overall, given that Bennie Fowler, the team's No. 3 receiver in training camp, is still trying to come back from the fracture near his right elbow that he suffered in the preseason opener. -- Jeff Legwold

Right guard Laurent Duvernay-Tardif has a high ankle sprain and is unlikely to be available when the Chiefs play the Texans on Sunday. The Chiefs would fill in with their veteran backup, Zach Fulton, who is a former starter, but the injury still comes at a bad time. Duvernay-Tardif had one of the best games of his career last week against the Chargers, and the Chiefs were hoping for offensive line stability, something they didn't have last season. Duvernay-Tardif was injured on the game's final play, quarterback Alex Smith's overtime touchdown run. -- Adam Teicher

The Raiders' makeshift offensive line, which helped them to that epic comeback win in New Orleans, has questions all over the place, especially on the right side. While backup right tackle Austin Howard practiced fully Wednesday for the first time since he sprained his right ankle on Sept. 1, center Rodney Hudson (knee), left guard Gabe Jackson (left knee) and right tackles Menelik Watson (groin) and Matt McCants (left knee) all sat out practice. Hudson and Jackson are expected to play in Sunday's home opener against the Falcons, but keep an eye on rookie guard/tackle Vadal Alexander, who was a healthy scratch Sunday in New Orleans. -- Paul Gutierrez

Joey Bosa is still nursing a hamstring injury and did not practice Wednesday, which means the rookie defensive end will likely miss his second game when the Chargers play host to the Jaguars in the team's home opener on Sunday. Bosa has not participated in a padded practice since he signed his rookie deal on Aug. 29. "Like I've been saying, he's day-to-day," Chargers coach Mike McCoy said. "I really can't give you a great update until he's out here in pads and he's out here practicing with the team. Then his odds will go way up, whether or not he's going to play in a game. But I'm never going to rule him out until he's officially out." -- Eric D. Williams

NFC EAST

Left tackle Tyron Smith (stinger) and cornerback Orlando Scandrick (hamstring) were knocked from the opener because of injuries, but the Cowboys believe that because they were able to return to the game, there shouldn't be issues moving forward. Smith's injury was a reoccurrence of a training camp hit, and he is being fitted for a larger neck roll. Scandrick has battled through a hamstring injury before. Both players were able to go through full practices on Wednesday. -- Todd Archer

The Giants are shockingly healthy, even though they lost reserve linebacker J.T. Thomas for the season in the opener. All 22 starters are practicing this week and are expected to play. Linebacker Jonathan Casillas' hand might be the only concern, but that isn't serious. -- Jordan Raanan

Tight end Zach Ertz is expected to be sidelined this week after he suffered a rib displacement against the Browns. "It's a dangerous situation with a displaced bone," coach Doug Pederson said. "You are talking up around the neck and head area, so any type of blow again could do further damage to that. That's why it's a week-to-week deal to see how it heals and recovers." Trey Burton could have a fairly significant role in Ertz's absence. Starting cornerback Leodis McKelvin is also week-to-week because of a hamstring injury. Ron Brooks and rookie Jalen Mills will be called on to pull extra weight if he can't go. -- Tim McManus

The Redskins are a healthy team, and there isn't much concern, though defensive end Chris Baker was limited in practice because of rib and knee issues. Losing him would be a big blow, considering he is the team's best defensive lineman, but at this point, it appears he'll play. -- John Keim

NFC NORTH

The biggest injury concern for the Bears is still Kyle Long's left shoulder. Long is determined to play the entire year on a torn labrum, but he is often in visible pain during and immediately after games. Long deserves a ton of credit for attempting to play through such a difficult shoulder injury, but there is concern that eventually the shoulder will simply give out. Long is such an important member of the offensive line. It's hard to envision the Bears running the football successfully without him at right guard, where he has been voted to multiple Pro Bowls. -- Jeff Dickerson

DeAndre Levy missed practice Wednesday and was the only player not at least partially available for Detroit. If Levy were unable to play Sunday, it would leave a massive hole at linebacker. The team's depth there would be thin, and Kyle Van Noy or rookie Antwione Williams would likely have to fill in. The play of both would be a drop-off from one of the best coverage linebackers in the NFL. -- Michael Rothstein

Cornerback Sam Shields sustained his second concussion in less than nine months late in Sunday's win over the Jaguars. It was his fourth since 2011. He missed a month last time he was concussed, but the time before that, he played the following week. The Packers were so thin at cornerback on Wednesday -- rookie Josh Hawkins (hamstring) was also out -- that practice-squad receiver Herb Walker had to line up on defense. -- Rob Demovsky

Left tackle Matt Kalil was seen leaving the team's training facility in a T-shirt and shorts just before practice started Wednesday, and Kalil was listed as a non-participant because of the hip injury that has bothered him for a couple weeks. Kalil said at the end of training camp that he was simply "resting up some little things," but given the tackle's injury history -- and the task the Vikings face Sunday night against a blitz-heavy Packers defense -- it bears watching what the Vikings do with Kalil the rest of the week. -- Ben Goessling

NFC SOUTH

The Falcons' top two wide receivers, Julio Jones and Mohamed Sanu, are dealing with ankle injuries. Both were limited during Wednesday's practice, as the Falcons continued preparation for Sunday's matchup with the Raiders. Jones told ESPN he's going to be fine, while Sanu said "I'm good" when asked about his ankle. Another key offensive player, running back Devonta Freeman, was limited Wednesday by a quad injury. -- Vaughn McClure

Running back Jonathan Stewart showed up on the injury report with a sprained ankle that coach Ron Rivera expressed no concern about. Stewart isn't sure how he suffered it. Safety Dean Marlowe (hamstring) was limited in practice, but he appears close to being ready to give the Panthers much-needed depth at the position. -- David Newton

The Saints know they won't have top cornerback Delvin Breaux for about six weeks, which is a huge loss, considering they're about to face Odell Beckham Jr. and the Giants. The biggest issue this week is whether left tackle Terron Armstead can get closer to 100 percent with his quad injury. Armstead will play, but he admitted to shaking off some rust last week. He is one of the Saints' two or three best players and will face a tough challenge against Giants pass-rusher Olivier Vernon. -- Mike Triplett

This isn't really a question -- it's definitive that defensive end Jacquies Smith is done for the season because of a torn ACL. He led the team with four sacks this preseason and was the top pass-rushing defensive end the past two seasons. Although the Bucs have more of a rotation going along the defensive line, this still hurts. How much? That depends on who steps in. They'll have William Gholston for their base defense, but in terms of a pass-rusher? Noah Spence didn't line up on the left at all during camp. He's an option, as is Howard Jones. Also keep an eye out for DaVonte Lambert. -- Jenna Laine

NFC WEST

The biggest injury concern for the Cardinals this week is right guard Evan Mathis, who sustained a mid-foot sprain in the second quarter Sunday night. He didn't practice Wednesday, and coach Bruce Arians listed Mathis as day-to-day and added that the team will see how Mathis practices Thursday, if he's able to take the field. With defensive end Frostee Rucker out two to three weeks because of an MCL injury, Ed Stinson has been taking his snaps, and Rodney Gunter has been working at right end. -- Josh Weinfuss

The Rams need as much help as they can get at wide receiver, but it doesn't look like they'll get it immediately. Nelson Spruce (knee) and Pharoh Cooper (shoulder) were both inactive for Week 1 and probably won't be available in Week 2. Rams coach Jeff Fisher said Spruce is "probably a week or two away." He has yet to comment on Cooper, who injured himself while making an acrobatic catch in the third preseason game, but shoulder injuries take time. Both can be major assets in the intermediate passing game that suits Case Keenum's skill set. -- Alden Gonzalez

The 49ers came out of the season opener relatively healthy, with only two additions to the injury report Wednesday. One guy to keep an eye on is defensive lineman Arik Armstead. He has been battling a shoulder issue, and that limited him in the preseason and in Wednesday's practice. The Niners used him mostly on passing downs in the opener, but they're hoping to work him in more as he continues to manage the injury. He was effective in a fairly small sample size against the Rams, and the 49ers are hoping more reps mean a breakout season for the 2015 first-round pick. -- Nick Wagoner

Russell WIlson's right ankle will be in the spotlight Sunday against the Rams. Wilson suffered a sprain last week against the Dolphins, but he practiced Wednesday, and offensive coordinator Darrell Bevell said he expects the quarterback to be "full go" this weekend. If Wilson is limited from a mobility standpoint on Sunday, Bevell will have to adjust the game plan accordingly. But barring a setback, the team is counting on Wilson to start. He has never missed a game in his NFL career. -- Sheil Kapadia