FRIDAY, May 11, 2018 (HealthDay News) -- Americans are fast becoming a very depressed lot.

New research shows there's been a sharp spike in cases of major depression in the United States in recent years, especially among teens and millennials.

The Blue Cross Blue Shield Association analysis of medical claims data showed that the overall rate of major depression was 4.4 percent and that diagnosis rates rose 33 percent between 2013 and 2016. Those rates increased 63 percent among teens and 47 percent among millennials.

Diagnosis rates in 2016 varied by as much as 300 percent between states, from a high of 6.4 percent in Rhode Island to lows of 2.1 percent in Hawaii and 3.2 percent in Nevada.

Diagnosis rates differed by as much or more than 400 percent among cities, from a high of 6.8 percent in Topeka, Kan., to lows of 1.5 percent in Laredo, Texas, and 2 percent in McAllen/Edinburg/Mission, Texas.

Women were twice as likely to be diagnosed with major depression than men, 6 percent vs. 3 percent, according to the health insurance company's Health of America Report, released Thursday.

People with major depression are nearly 30 percent less healthy, on average, than those without depression. Eighty-five percent of people with major depression have one or more other serious chronic health conditions, and nearly 30 percent have four or more other health conditions, according to the report authors.

People with major depression also use health care services more than those without a depression diagnosis, resulting in significantly higher health care spending -- about $10,673 compared to $4,283.

"Major depression diagnoses are growing quickly, especially for adolescents and millennials," said Trent Haywood, senior vice president and chief medical officer for Blue Cross Blue Shield.

"The high rates for adolescents and millennials could have a substantial health impact for decades to come. Further education and research is needed to identify methods for both physicians and patients to effectively treat major depression and begin a path to recovery and better overall health," Haywood said in a association news release.