On 22 August 1965 Janet Reimer was granted her dearest wish: she gave birth to twins. The two boys, Brian and Bruce, were healthy babies, but they would lead tragic lives, blighted by one scientist's radical theory.

When they were seven months old, the boys, who lived in Winnipeg, Canada, were sent to the local hospital for a routine circumcision. Unfortunately the doctor in charge of the procedure was using electrical equipment, which malfunctioned several times. On the last trial, Bruce's entire penis was burnt off. Brian was not operated on. The family were distraught. In the Sixties plastic surgery was not an option: even today it is not recommended that new-borns undergo penis reconstruction operations.

It wasn't until several months later that Janet and her husband, Ron, saw a television programme that gave them some hope. Dr John Money, a highly renowned sexologist, featured in a debate about sex change operations on transsexuals. He had brought a transsexual with him who was convincingly feminine looking.