CHEYENNE WELLS, Colo. — The Old West has decided it is fed up with the New West.

At Nan’s convenience store here in eastern Colorado, where the front door tells visitors that “Gun Control Is Hitting Your Target,” the farmers, crop sprayers, mechanics and retirees who gather for morning coffee say they have had enough of the state and its Democratic leaders. They bristle at gun control laws and marijuana shops, green energy policies and steps to embrace gay marriage and illegal immigrants.

“I would’ve never believed the state of Colorado would become this liberal,” said Lyle Miller, who owns the convenience store. “I’m afraid for my grandchildren. I want them to have the same heritage I had.”

So in November, this rural county and 10 others will hold a quixotic vote on whether to secede from Colorado and work to form their own state, one that would cherish the farm towns and conservative ideals that people here say have been lost in Denver’s glassy downtown lofts or Aspen’s million-dollar ski condos. It would be called New Colorado, or maybe North Colorado — a prairie bulwark against the demographic changes and urbanization that are reshaping politics and life across this and other Western states.

“People think this is a radical idea,” said Jeffrey Hare, a leader of the 51st State Initiative, which supports secession. “It’s really not. What we’re attempting to do is restore liberty.”