A million-dollar hydroponic marijuana crop has been discovered in a rural home in central Victoria, with police investigating its connection to a sophisticated Vietnamese drug syndicate.

Police said 500 plants were found throughout a home in Millers Lane, Rushworth, east of Bendigo on Tuesday morning.

The house was identified during two simultaneous drugs taskforce investigations, codenamed Kanji and Reexposing, that have identified an organised Vietnamese crime syndicate.

Six alleged members of the syndicate, including two suspected kingpins, were charged almost two weeks ago following raids in Melbourne's north and west in which $10 million in drugs were seized including cannabis, ice, heroin and cocaine.

A sports bar manager who allegedly rented 21 properties in his name for the syndicate has also been arrested and charged in raids in early January in which almost $3 million in cannabis was found.

Assistant Commissioner Stephen Fontana told media previously that the syndicate would have international links, with the heroin and cocaine sourced internationally.

He said the investigation into the syndicate had crossed over with a number of other operations and other organised Australian crime groups, but did not involve outlaw motorcycle gangs.