A-League leaders Brisbane have suffered a double setback before Saturday's A-League clash with Perth at Suncorp Stadium.

Goalkeeper Michael Theo has been scratched due to a shoulder injury while defender Jade North is being rested after complaining of tightness in his groin.

Youngster Matt Acton will debut for the Roar in goal, becoming the 100th player to represent the club.

"We've rested him for six days and we feel that if we get another six days rest in him, he'll be ready for the game after," coach Mike Mulvey said of Theo's injury.

"It's Matty Acton's time to shine."