Major League Baseball and 12 players have agreed to 50-game suspensions for their roles in the Biogenesis case, multiple media outlets reported Monday, with the harshest penalty, against Alex Rodriguez, set to be handed down in the afternoon.

The players' union made a late appeal to MLB for a deal for Rodriguez but was told there would be no more negotiations. He will be punished under the Joint Drug Agreement and other areas of the league's collective-bargaining agreement but will be allowed to play while he appeals.

The other players, initially confirmed by FoxSports.com, who have agreed to the suspensions without the right to appeal are:

Rangers All-Star outfielder Nelson Cruz was among 12 players who agreed to 50-game suspensions for their roles in the Biogenesis case. Tom Pennington/Getty Images

• Nelson Cruz, Rangers outfielder

• Everth Cabrera, Padres shortstop

• Jhonny Peralta, Tigers shortstop

• Antonio Bastardo, Phillies reliever

• Francisco Cervelli, Yankees catcher (on DL)

• Jordany Valdespin, Mets outfielder (minors)

• Jesus Montero, Mariners catcher (minors)

• Cesar Puello, Mets outfielder (minors)

• Sergio Escalona, Astros pitcher (minors)

• Fernando Martinez, Yankees outfielder (minors)

• Fautino De Los Santos, free-agent pitcher

• Jordan Norberto, free-agent pitcher

Beyond Rodriguez, the suspensions come with potentially stiff consequences for at least two of the players and their teams. Cruz, Cabrera and Peralta were each All-Stars this season, with Cruz's Rangers and Peralta's Tigers contending for playoff berths.

Milwaukee outfielder Ryan Braun was the first player to reach an agreement with MLB on a suspension for his connection to the Biogenesis case. The 2011 NL MVP accepted a season-ending 65-game suspension last month.