Soul Pattison chemist on Sydney's Pitt Street Mall is set to close its doors in June after 145 years following the sale of the building, in which it occupies the ground floor.

In a deal, said to be worth about $100 million, the property at 160 Pitt Street, owned by Washington H Soul Pattinson and Company has been sold to the private group Kingvest, which is run by Sydney retail landlord Victor Comino.

Washington H. Soul Pattinson building at 160 Pitt Street Mall has been sold for circa $100m.

The deal will shake up Pitt Street Mall, said to be one of the 10 most expensive retail strips by rent per capita in the world, and will add to Mr Comino's $400 million portfolio, which also includes the Apple, Telstra and Louis Vuitton stores on the King and George corner.

It is the first large-scale retail site that has been offered along the strip since November 2015 and was one of only four freehold buildings within Pitt Street Mall retail precinct, running between King and Market streets.

JLL’s Simon Rooney and Rob Sewell, who advised Washington H Soul Pattinson and Co on the deal, said the Sydney CBD is going through dramatic overhaul which will attract even more customers and tourists to the CBD and drive growth in retail spending - particularly along Pitt Street Mall.

“The infrastructure upgrades in the Sydney CBD and residential development will underpin the long term demand for retail space,'' Mr Rooney said.

''As a result of the high retailer demand for presence along Pitt Street, it now commands some of the highest rents in the world, with recent evidence showing rates of $12,000 per square metre per annum - $15,000 per sqm p.a.''