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Fontella Bass -- famous for her epic,1965 hit song "Rescue Me" -- died Wednesday in Missouri. She was 72.

According to Fontella's family, the singer passed away in a St. Louis hospital from complications she suffered following a heart attack three weeks ago. Bass also had several strokes since 2005.

The R&B star scored a ton of hits over her career -- including "You'll Miss Me (When I'm Gone)" and "Don't Mess Up a Good Thing" -- but none as big as "Rescue Me."