A controversial flu researcher has modified the flu virus responsible for the 2009 pandemic to allow it evade the human immune system. His lab’s previous works include recreating the Spanish flu and making a deadly bird flu strain highly transmittable.

The yet-to-be-published research by Professor Yoshihiro Kawaoka and his team is meant to give scientists better ways to fight influenza outbreaks, but gives chills to some people in academia, who are fearful that accidental release of the strain would result in a global disaster, according to a report by the Independent.

At his level-3 biosafety lab at Wisconsin University’s Institute for Influenza Virus Research in Madison, Kawaoka experimented with the H1N1 flu strain that was responsible for the pandemic in 2009, dubbed the swine flu pandemic by the media. The work resulted in a mutated strain that is able to evade the human antibodies, effectively rendering humans defenseless against the virus.

“He took the 2009 pandemic flu virus and selected out strains that were not neutralized by human antibodies. He repeated this several times until he got a real humdinger of a virus,” a scientist familiar with Kawaoka’s research told the British newspaper.

“He’s basically got a known pandemic strain that is now resistant to vaccination. Everything he did before was dangerous but this is even madder. This is the virus,” he added.

H1N1 flu had caused serious outbreaks and two recorded pandemics, the first being the notorious Spanish flu of 1918. Kawaoka’s newest work is partially derived from his experience in recreating the deadly strain.

The first H1N1 pandemic left between 50 and 100 million people dead, according to estimates. The 2009 pandemic death toll is debated, with some estimates putting the number as high as 560,000, most of them in Africa and Southeast Asia.

The professor assured the newspaper that the mutant virus is well under control in his lab and that making a strain that can beat human immune system will help epidemiologists be prepared for a contingency of a similar mutation occurring naturally.

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