Herman Cain's path to the Federal Reserve Board could get blocked before President Donald Trump even nominates him.

At least three GOP senators plan to vote against the former Godfather's Pizza CEO and Kansas City Fed chairman if Trump formally chooses him for the central bank seat, according to multiple reports. If Cain loses one more Republican and all Democrats oppose him as expected, his path to the Fed board would be blocked.

Sen. Mitt Romney, R-Utah, expects to oppose Cain's nomination if it comes before the Senate, a spokeswoman for the Romney confirmed. Sen. Lisa Murkowski, R-Alaska, has said she will not support Cain for the Fed seat, according to a spokeswoman for Murkowski.

Sen. Cory Gardner, R-Colo., also reportedly plans to vote against Cain, who unsuccessfully ran for president in 2012. A spokesman for Gardner did not immediately respond to CNBC's request to comment.