Hamilton Fish, the president and publisher of The New Republic, has resigned from the magazine after allegations of inappropriate conduct. The move came less than a week after Mr. Fish was asked to take a leave of absence pending an investigation into recent complaints from women about their interactions with him.

In a letter on Friday to Win McCormack, the owner of The New Republic, Mr. Fish wrote that he was submitting his resignation “after much reflection.”

“As I understand it, some employees, to my deep dismay, complained this week that my presence had led them to feel uncomfortable at The New Republic,” he wrote, adding later, “It’s my sense that our office culture has been harmed, and the best way for me to help the organization move past this is by withdrawing.”

He added: “Women have longstanding and profound concerns with respect to their treatment in the workplace. Many men have a lot to learn in this regard. I know I do.”