Salesforce.com Inc. investors need not fret too much, as Wall Street analysts rushed to calm those worried that the cloud computing company may be close to buying Twitter Inc.

Salesforce stock CRM, +1.11% slipped 0.1% in afternoon trade, toward the lowest close since March 8. On Friday, it had tumbled 5.6% after CNBC reported that Twitter was closing in on a buyout deal, and that Salesforce was one of the potential suitors.

Raymond James analyst Terry Tillman said that while buying Twitter could provide Salesforce with some technology synergies, he believes the likelihood that a deal could generate shareholder returns represents “quite a stretch” and would be wrought with execution risk.

“ ‘Please don’t focus on what could become a bad science experiment with an acquisition of Twitter.’ ” — Terry Tillman, analyst at Raymond James

In a research note titled “Tweedle Dee, Twitter Dumb: Please Don’t Do It,” Tillman wrote:

“We implore management to not pursue a large dilutive acquisition such as this that could distract from maximizing what we see as a confluence of growth catalysts and mating and cash flow expansion opportunities.”

He said if Salesforce just can’t help itself making an aggressive acquisition, then it should just acquire Workday Inc. “Please don’t focus on what could become a bad science experiment with an acquisition of Twitter,” he wrote.

“We do not comment on rumors,” a Salesforce.com spokesperson said in an emailed statement to MarketWatch.

Twitter’s stock TWTR, +7.09% dropped more than 4% intraday Monday, before reversing higher in afternoon trade, after Bloomberg reported Walt Disney Co. DIS, +1.43% was working with an adviser on a possible bid for the company. Earlier losses followed a downgrade to a rare bearish rating at Oppenheimer, which said the company was worth significantly less to a potential suitor than what the current stock price was suggesting. The stock had soared 21% in the previous session.

Disney did not immediately respond to a request for comment.

Albert Fried & Co. analyst Richard Tullo said a strategic case could be made for Disney to buy Twitter, if one considers that streaming video might be disruptive to live sports, but “a deal makes no sense” on the surface, especially because the stock is expensive “on virtually every metric.”

BTIG’s Rich Greenfield said he still believes Disney should have interest in buying Twitter, but valuations don’t add up. “The problem is Twitter doesn’t make money, so it’d be a highly dilutive acquisition,” Greenfield told MarketWatch.

Among other media companies said to have interest in Twitter, a Verizon Communications Inc. VZ, +0.35% spokesperson told MarketWatch that a recent rumor it had made a bid for Twitter was “not true,” but had “no comment” about reports of interest in a deal.

Why a Salesforce-Twitter deal wouldn't work

Nomura analyst Frederick Grieb said he understands why Salesforce.com has been brought up as a potential suitor, because its customers are now more often interacting with service professionals through social media, and considering it was a bidder for LinkedIn before losing out to Microsoft Corp.

That said, a deal is “unlikely,” as “the costs could outweigh the benefits,” Grieb said. “While we believe there is a rationale for Salesforce to acquire Twitter, we are hopeful that given Salesforce’s negative stock price reaction to news that the company could be in talks with Twitter, that Salesforce will decide on the less risky path of organic growth.”