Democrats on Thursday blocked a last-ditch effort from Republicans to stop the Iran nuclear deal by linking the agreement to Israel and American prisoners.

Senators voted 53-45 on an amendment from Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellGraham: GOP will confirm Trump's Supreme Court nominee before the election Trump puts Supreme Court fight at center of Ohio rally The Memo: Dems face balancing act on SCOTUS fight MORE (R-Ky.) that would have prevented President Obama from lifting sanctions on Iran until the country releases American prisoners and publicly recognizes Israel's right to exist. Sixty votes were needed to move forward.

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Under the Iran Nuclear Agreement Review Act, Thursday is the final day for Congress to approve a resolution stopping the nuclear deal, though some conservatives dispute that deadline.

With Democrats having held firm in the Senate, it appears the nuclear pact — negotiated by the United States and other world powers — will begin taking effect next month.

While the amendment vote Thursday was intended to be politically tough for Democrats, the 42 Dems who are in favor of the Iran deal voted against the Republican leader's amendment.

Sens. Ben Cardin Benjamin (Ben) Louis CardinCongress must finish work on popular conservation bill before time runs out PPP application window closes after coronavirus talks deadlock Congress eyes tighter restrictions on next round of small business help MORE (D-Md.), Bob Menendez Robert (Bob) MenendezKasie Hunt to host lead-in show for MSNBC's 'Morning Joe' Senators ask for removal of tariffs on EU food, wine, spirits: report VOA visa decision could hobble Venezuela coverage MORE (D-N.J.) and Charles Schumer Chuck SchumerJacobin editor: Primarying Schumer would force him to fight Trump's SCOTUS nominee CNN's Toobin: Democrats are 'wimps' who won't 'have the guts' to add Supreme Court seats Republican senator says plans to confirm justice before election 'completely consistent with the precedent' MORE (D-N.Y.), who are among a small group of Democrats who oppose the Iran deal, also joined supporters in voting "no."

Sen. Joe Manchin Joseph (Joe) ManchinTrump meets with potential Supreme Court pick Amy Coney Barrett at White House Names to watch as Trump picks Ginsburg replacement on Supreme Court Momentum growing among Republicans for Supreme Court vote before Election Day MORE (D-W.Va.), who also opposes the Iran deal, was the only Democrat to vote for the amendment.

Cardin, the ranking member of the Foreign Relations Committee, said ahead of the vote that even if Iran does recognize Israel, "I must tell you that I would have no trust in their statement, or confidence in their statement."

"This conditional approval gives up any of the disapproval resolution on the nuclear agreement," he added. "That makes absolutely no sense whatsoever."

Menendez agreed, saying that he voted "no" because he does not "want to give any idea that we would support this agreement ... simply because the hostages would be released and Iran would recognize Israel."

McConnell defended his amendment, suggesting that passing it was the "least" the Senate could do if lawmakers weren't willing to pass a resolution of disapproval.

“I understand that there is strong division in this Senate — a bipartisan majority opposed, a partisan minority in favor — over the broader Iran deal," he added. “But at the very least, we should be able to come together over the vote we’ll take today."

But his tactics drew pushback from his fellow Republicans.

Sen. Jeff Flake Jeffrey (Jeff) Lane FlakeJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Republican former Michigan governor says he's voting for Biden Maybe they just don't like cowboys: The president is successful, some just don't like his style MORE (R-Ariz.) said that while he supports releasing hostages and Iran supporting Israel, “should a whole agreement be based on those two items? No."

Flake at one time was considered the Republican most likely to support Obama’s diplomatic pact, though he ended up coming out against it. He added that while he would support McConnell’s amendment for the procedural vote, he would vote against it if it were to come up for a final vote.

It's not the first time Israel has tied up the Senate. Sens. Marco Rubio Marco Antonio RubioMurky TikTok deal raises questions about China's role Sunday shows preview: Justice Ginsburg dies, sparking partisan battle over vacancy before election Florida senators pushing to keep Daylight Savings Time during pandemic MORE (R-Fla.) and Tom Cotton Tom Bryant CottonGOP brushes back charges of hypocrisy in Supreme Court fight Trump uses bin Laden raid to attack Biden Battle lines drawn on precedent in Supreme Court fight MORE (R-Ark.) earlier this year tried to force a vote on an amendment linking support to Israel to the Iran review bill.

But their move effectively shut down debate, with Democrats, and some Republicans, arguing that their amendment was a poison pill for the legislation.

The Obama administration, and Democrats who support the deal, have long argued that the pact is focused solely on Iran’s nuclear program and does not address other areas of concern, including the country’s support for terrorist groups.

Minority Leader Harry Reid Harry Mason ReidOn The Trail: Battle over Ginsburg replacement threatens to break Senate Democrats fear Russia interference could spoil bid to retake Senate Graham signals support for confirming a Supreme Court nominee this year MORE (D-Nev.) doubled down on that position Thursday, saying that when it comes to the agreement, the issue has already been “decided” in the Senate.

“What the Republican colleagues are doing right now is very, very cynical,” he added. “They’re taking serious issues and turning them into pawns in a political issue.”

Sens. Rand Paul Randal (Rand) Howard PaulSecond GOP senator to quarantine after exposure to coronavirus GOP senator to quarantine after coronavirus exposure The Hill's Morning Report - Sponsored by National Industries for the Blind - Trump seeks to flip 'Rage' narrative; Dems block COVID-19 bill MORE (R-Ky.) and Marco Rubio (R-Fla.), who participated in last night’s presidential debate in California, missed the amendment vote.