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Table S1 Years that medical marijuana laws (MML) were enacted for the 50 US states up to 2012 and how participants in these states were coded in Models 1–3. Table S2 Differences in predicted prevalence of driving under the influence of cannabis or alcohol, 1991–1992 to 2001–2002a: non‐early and early‐MML states (model 2)d. Table S3 Differences in predicted prevalence of driving under the influence of cannabis or alcohol, 2001–2002 to 2012–2013a: never‐MML, early‐MML, and late‐MML states (model 3). Table S4 Sensitivity analysis: difference in predicted prevalence of driving under the influence of marijuana or alcohol, with participants in the 11 states not common to the 3 surveys included, 1991–1992 to 2012–2013: never‐ versus ever‐MML states (model 1). Table S5 Sensitivity analysis: differences in predicted prevalence of driving under the influence of marijuana or alcohol, with participants in the 11 states not common to the 3 surveys included, 1991–1992 to 2001–2002a: non‐early and early‐MML states (model 2)d. Table S6 Sensitivity analysis: differences in predicted prevalence of driving under the influence of marijuana or alcohol, with participants in the 11 states not common to the 3 surveys included, 2001–2002 to 2012–2013a: never‐MML, early‐MML, and late‐MML states (model 3). Table S7 Difference in predicted prevalence of driving under the influence of marijuana or alcohol, with participants who only reported using cannabis and alcohol 1–11 times included, 1991–1992 to 2012–2013: never‐ versus ever‐MML states (model 1). Table S8 Differences in predicted prevalence of driving under the influence of marijuana or alcohol, with participants who only reported using cannabis and alcohol 1–11 times included 1991–1992 to 2001–2002a: non‐early and early‐MML states (model 2). Table S9 Differences in predicted prevalence of driving under the influence of marijuana or alcohol, with participants who only reported using cannabis and alcohol 1–11 times included, 2001–2002 to 2012–2013a: never‐MML, early‐MML, and late‐MML states (model 3). Table S10 Predicted prevalence of driving under the influence of cannabis only, alcohol only, or both by survey. Table S11 Sensitivity analysis: difference in predicted prevalence of driving under the influence of marijuana and/or alcohol, using multinomial logistic regression with a four category outcome variable: neither DUI‐C nor DUIA, DUIC only, DUIA only, both DUIC and DUIA, 1991–1992 to 2012–2013: never‐ versus ever‐MML states (model 1). Table S12 Sensitivity analysis: difference in predicted prevalence of driving under the influence of marijuana and/or alcohol, using multinomial logistic regression with a four category outcome variable: neither DUI‐C nor DUIA, DUIC only, DUIA only, both DUIC and DUIA, 1991–1992 to 2001–2002a: non‐early and early‐MML states (model 2)d. Table S13 Sensitivity analysis: difference in predicted prevalence of driving under the influence of marijuana and/or alcohol, using multinomial logistic regression with a four‐category outcome variable: neither DUIC nor DUIA, DUIC only, DUIA only, both DUIC and DUIA, 2001–2002 to 2012–2013a: never‐MML, early‐MML, and late‐MML states (model 3). Table S14 Response rates to survey questions on driving under the influence by state medical marijuana law (MML) status. Table S15 Testing the parallel paths assumption for Colorado and the late‐MML states: differences in predicted prevalence of driving under the influence of cannabis during the earlier period, 1991–1992 to 2001–2002a. Figure S1 Medical marijuana laws (MML) and driving under the influence of marijuana, past 12 months, during (a) overall period (1991–1992 to 2012–2013), (b) early period (1991–1992 to 2001–2002) with California as stand‐alone state, (c) late period (2001–2002 to 2012–2013) with California and Colorado as stand‐alone states. Figure S2 Medical marijuana laws (MML) and driving under the influence of alcohol, past 12 months, during (a) overall period (1991–1992 to 2012–2013), (b) early period (1991–1992 to 2001–2002) with California as stand‐alone state, (c) late period (2001–2002 to 2012–2013) with California and Colorado as stand‐alone states.