LOS ANGELES - The New Madrid fault zone in the nation's midsection is active and could spawn large earthquakes, scientists reported Thursday.

It's "not dead yet," said U.S. Geological Survey seismologist Susan Hough, who was part of the study published online by the journal Science.

Researchers have long debated just how much of a hazard New Madrid poses. The zone stretches 150 miles, crossing parts of Arkansas, Illinois, Indiana, Kentucky, Mississippi, Missouri and Tennessee.

In 1811 and 1812, it unleashed a trio of powerful jolts - measuring magnitudes 7.5 to 7.7 - that rattled the central Mississippi River valley. Chimneys fell and boats capsized. Farmland sank and turned into swamps. The death toll is unknown, but experts don't believe there were mass casualties because the region was sparsely populated then.

Unlike California's San Andreas and other faults that occur along boundaries of shifting tectonic plates, New Madrid is less understood since it's in the middle of the continent, far from plate boundaries.

Previous studies have suggested that it may be shutting down, based on GPS readings that showed little strain accumulation at the surface. Other research came to the same conclusion by blaming ongoing quake activity on aftershocks from the 1800s, which would essentially relieve strain on the fault.

The latest study suggests otherwise. Hough and USGS geophysicist Morgan Page in Pasadena, Calif., analyzed past quakes in the New Madrid region and used computer modeling to determine that the continuing tremors are not related to the big quakes two centuries ago.

"Our new results tell us that something is going on there, and therefore a repeat of the 1811-1812 sequence is possible," Hough said.

The USGS estimates there's a 7 to 10 percent chance of that happening in the next 50 years.

Philip Carpenter, a professor in the department of geology and environmental sciences at Northern Illinois University, said he's been to meetings where heated debates erupt over the future of the New Madrid fault zone.

"Intraplate earthquake activity is very difficult to understand," he said.

If there were a significant earthquake along the fault line, residents of northern Illinois "would definitely feel a major shock ... and possibly experience some minor damage, such as pictures falling, plates and dishes slipping off shelves and tables."

"Earthquake waves that are strong enough to be felt travel enormous distances through the crust and mantle of the central and eastern U.S. because it is older and more solid than the crust and mantle of the western U.S."

Arthur Frankel, a seismologist with the USGS in Seattle who had no role in the study, said the latest results seem plausible. His recent field work using GPS shows significant movement of land along the fault in the past decade, indicating a buildup of strain that could lead to potentially dangerous quakes.

Others said this won't end the debate about the hazards on the New Madrid seismic zone.

Andrew Newman, a geophysicist at the Georgia Institute of Technology, said the method used in the study works well for faults along plate boundaries, but he's unsure if it applies to enigmatic faults like New Madrid.

Register Star reporter Dorothy Schneider contributed to this report.