



RESEARCH LETTER Year : 2016 | Volume : 7 | Issue : 1 | Page : 22-24

Inhibition of astrocyte activation is involved in the prevention of postoperative latent pain sensitization by ketamine and gabapentin in mice



Elizabeth Romero-Alejo, Margarita M Puig, Asunción Romero

Department of Anesthesiology, Pain Research Unit, Universitat Autónoma de Barcelona, Barcelona, Spain



Date of Submission 27-Sep-2015 Date of Decision 04-Nov-2015 Date of Acceptance 01-Feb-2016 Date of Web Publication 29-Mar-2016

Correspondence Address:

Asunción Romero

Department of Cellular Biology, Physiology and Immunology, Faculty of Veterinary Medicine, Universitat Autónoma de Barcelona, Barcelona

Spain

Source of Support: None, Conflict of Interest: None Check 1

DOI: 10.4103/0976-500X.179357





How to cite this article:

Romero-Alejo E, Puig MM, Romero A. Inhibition of astrocyte activation is involved in the prevention of postoperative latent pain sensitization by ketamine and gabapentin in mice. J Pharmacol Pharmacother 2016;7:22-4

How to cite this URL:

Romero-Alejo E, Puig MM, Romero A. Inhibition of astrocyte activation is involved in the prevention of postoperative latent pain sensitization by ketamine and gabapentin in mice. J Pharmacol Pharmacother [serial online] 2016 [cited 2020 Sep 21];7:22-4. Available from: http://www.jpharmacol.com/text.asp?2016/7/1/22/179357

Figure 1: Effects of ketamine (50 mg/kg) and gabapentin (100 mg/kg) in a murine model of incisional pain. Data expressed as mean ± standard error mean.*P < 0.001 versus baseline; #P < 0.001 versus INC + SS



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Figure 2: Effects of ketamine (50 mg/kg) and gabapentin (100 mg/kg) on: (a) Microglia immunoreactivity. A1: Histograms (mean ± standard error mean): Number of ionized calcium binding adapter molecule 1 positive cells. A2: Representative photomicrographs of Iba-1 positive cells expression by immunofluorescence in spinal cord at day 1. (b) Astrocyte immunoreactivity. B1: Histograms (mean ± standard error mean)% of glial fibrillary acidic protein stained area. B2: Representative photomicrographs of glial fibrillary acidic protein expression by immunofluorescence in spinal cord, at 1 and 21 days after surgery.*P < 0.001 versus baseline; #P < 0.001 versus INC + SS



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References

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