Seth Rogen has a a new enemy in the war on weed: Nancy Grace.

The HLN host was tweeting up a storm Wednesday night about Richard Kirk, a Denver man who allegedly shot and killed his wife during a 911 call after he had ingested marijuana.

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“Daddy allegedly snacks on marijuana and kills his wife! Is #PotToBlame” Grace tweeted, with her trademark goofy hashtags.

“If pot makes you mellow and laid back, why does this guy allegedly turn berserk and gun down his wife? #PotToBlame” she added.

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After Grace’s anti-pot rant, Rogen shot a Twitter missive at the HLN host to express his rage.

“You are a f*cking dumbass,” he said bluntly.

Hours later, Grace responded to the pot-loving comedian’s dis.

“hi seth! thx for watching!” she tweeted.

Cops say daddy eats marijuana & goes crazy. He shoots his wife in the head while she pleads with 9-1-1 for help! #PotToBlame? - Nancy Grace (@NancyGraceHLN) April 17, 2014

If pot makes you mellow and laid back, why does this guy allegedly turn berserk and gun down his wife? #PotToBlame? - Nancy Grace (@NancyGraceHLN) April 17, 2014

How many people must die before this stops?! #PotToBlame? - Nancy Grace (@NancyGraceHLN) April 17, 2014