The opera star Plácido Domingo resigned on Wednesday from his position as general director of Los Angeles Opera, a company that he helped found, and withdrew from his upcoming performances there. They were his last scheduled engagements in the United States after others were canceled amid allegations that he had sexually harassed multiple women over several decades.

His departure from Los Angeles Opera raised the possibility that the storied, five-decade American opera career of Mr. Domingo, 78, could be drawing to a close. The announcement came a week after he agreed to withdraw from a run of performances at the Metropolitan Opera and said that he would not return there, and after several other prominent American arts organizations canceled his appearances. His European calendar, however, remains full.

Mr. Domingo said in a statement that his ability to continue with the Los Angeles company had been “compromised” since The Associated Press in recent months reported allegations that he had sexually harassed numerous women over the years.

“I hold Los Angeles Opera very dearly to my heart and count my work to create and build it as among my most important legacies,” Mr. Domingo said in a statement to The New York Times. “However, recent accusations that have been made against me in the press have created an atmosphere in which my ability to serve this company that I so love has been compromised.”