The mother of a 4-year-old girl killed Thursday by a bullet wound to her face has been charged with third degree murder, according to police.

The mother was identified as 25-year-old Shakeya Holmes.

An arrest warrant was also issued for Holmes' boyfriend in connection with the little girl's death.[[384320141, C]]

Earlier Friday, police said the girl appeared to have shot herself with a handgun.

Police have not yet identified the girl, who was found by police with a gunshot to her eye at a North Philadelphia house where she lived with her mother and a younger sister.[[384217951, C]]

The investigation has revealed that the gunshot appears self-inflicted, a police spokeswoman said. Charges against the mother was confirmed on Friday evening.

EMS rushed to the Montgomery Townhomes on the 1800 block of North 20th Street shortly after noon Thursday. Medics then took the girl to Hahnemann Hospital where she died around 1 p.m., police said.

[PHI] 4-year-old shot

The girl's mother and a 3-year-old sister were in the home when the child was shot, police said. Police recovered a gun from inside the home.

Neighbors said the mother ran outside holding her daughter and yelled for help.

"Her little sister standing over her, I said what happened, she said, she got shot with a gun," Margie Malabet recalled the frantic scene when she ran to help after hearing the mother's cries, "Save my baby, please, save my baby."

NBC10’s Deanna Durante was live on the scene as the story was developing Thursday afternoon