Based on Esposito's life, the single-camera entry will follow the lives of two very different sisters in their 30s.

You're the Worst creator Stephen Falk is ready to explore gender and sexuality for FX.

Falk is teaming with Cameron Esposito for an untitled comedy that is based on the life of the stand-up comedian, The Hollywood Reporter has learned.

The single-camera entry follows the relationship between Cameron (played by Esposito) and Eve, two very different sisters in their early 30s — one straight and one gay. The potential series, which is in development at FX, is poised to explore the spectrum of gender, sexuality, options and mistakes that exist in 2016. It's described as an update on the "can she have it all" premise to "What if she had it all and it sucked so bad she had to start again." Esposito is set to star in the comedy about adulthood without a finish line.

Falk and Esposito are set to pen the script and exec produce alongside Brillstein Entertainment Partners. FX declined comment.

The Esposito vehicle marks the third sale for Falk under his rich overall deal with FX Productions and FX Networks. The Orange Is the New Black and Weeds alum, whose critical darling FXX comedy returns this year for a third season, is also reteaming with three You're the Worst writers for two different comedies for FX. The first, from Alison Bennett, is a female take on the "you can't go home again" story. Falk and Bennett will co-write the script. The second, Join Me, is from YTW scribes Franklin Hardy and Shane Kosakowski, who will pen the adaptation of the book of the same name by Danny Wallace. Falk exec produces.

Out comic Esposito, meanwhile, has seen her career take off over the past few years. The L.A.-based stand-up comic, actress and writer has had recurring roles on IFC's Maron and recently wrapped a supporting role in the feature Mother's Day, starring Julia Roberts, Jennifer Aniston and Kate Hudson. Her indie features Sleight and First Girl I Loved were both Sundance 2016 selections, with a third, Operator, set to bow at South by Southwest. Her third album and debut stand-up special, Marriage Material, is due March 24 on NBC's Digital platform Seeso, where Esposito and her wife, Rhea Butcher, are also prepping stand-up series Take My Wife. Her debut book will be released this year by Grand Central Publishing.

Falk is repped by UTA and Jackoway Tyerman; Esposito is with Gersh, Brillstein and Hansen Jacobson.