LOS ANGELES — A prominent Republican fund-raiser was charged Wednesday in a federal grand jury indictment with orchestrating a Ponzi scheme that defrauded investors of hundreds of millions of dollars.

The fund-raiser, Timothy Durham, 48, was arrested early in the morning at his West Hollywood home and charged with 12 counts of securities and wire fraud in federal court here.

Prosecutors accuse Mr. Durham of taking money investors trusted to his business, the Fair Finance Company, and using it make loans to himself and his businesses; earlier investors were repaid with money from newer ones.

From 2002 to 2009, more than 5,000 investors were defrauded out of more than $200 million, the indictment said. The company later filed for bankruptcy.