USA TODAY Sports college football staff picks for Week 3

USA TODAY Sports

Show Caption Hide Caption College football game of the week: Clemson vs. Louisville SportsPulse: USA TODAY Sports' George Schroeder breaks down Louisville and how Lamar Jackson will fair against the Clemson Tigers' vaunted defense.

No. 2 Clemson and No. 14 Louisville met in one of the best games in the regular season last year. The two schools will clash again in the centerpiece matchup in Week 3.

Cardinals quarterback Lamar Jackson had 457 yards of total offense, but the Tigers rallied with two late scores for the win last year. Jackson will be tested Saturday night by a Clemson defensive front that had 11 sacks against Auburn last week.

The other Top 25 matchup takes place in Gainesville. No. 23 Tennessee tries for its second consecutive defeat of No. 25 Florida after ending its 11-game losing streak to the Gators last year.

With both Butch Jones and Jim McElwain under the microscope, the loser will take a hit in the SEC East race and its coach also must deal with an increase of pressure from an unhappy fan base.

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