Mayor Bill de Blasio skipped the NYPD’s monthly crime rate announcement for the first time in more than two years on Tuesday and instead hunkered down in Gracie Mansion amid devastating new poll numbers and a damning profile by the New York Times.

De Blasio’s absence from the news conference at One Police Plaza marked the first time he’s missed a chance to crow about the Big Apple being the “safest big city in America” since July 2017, and only the third time since he began making monthly appearances with police officials in January 2016.

When asked why his boss wasn’t present on Tuesday, NYPD Commissioner James O’Neill blamed an unspecified “scheduling conflict.”

A mayoral spokesperson said de Blasio was holding meetings at his official residence and tending to matters related to his presidential campaign, but wouldn’t provide any details.

A public schedule released by his office on Monday night showed just one planned event – participation in the National Night Out Against Crime with O’Neill – but noted that details were still “being finalized.”

A poll released Tuesday morning by Siena College ranked de Blasio the single most unpopular political figure in New York state, with a staggering 57% of voters saying they viewed him unfavorably.

A second poll, released later in the day by Quinnipiac University, also showed that less than 1% of Democrats and Democratic-leaning voters would pick him to be the party’s presidential candidate.

Meanwhile, a 6,500-plus-word profile that was posted online ahead of publication in Sunday’s New York Times Magazine quoted several former allies blasting de Blasio’s performance as mayor and was summed up with the headline, “How Bill de Blasio Went From Progressive Hope to Punching Bag.”

One former de Blasio insider told The Post that the negative coverage in the Times – which “firmly” endorsed his re-election in 2017 – was the reason Hizzoner didn’t appear at the NYPD news conference.

“He has lived and died by this media availability for more than two years and then he doesn’t show the day he gets lambasted in the Times Magazine,” the source said.

“You do the math.”

De Blasio press secretary Freddi Goldstein said, “The mayor’s schedule was finalized days ago and made public last night. Any suggestion that a story or a poll played a role is both dishonest and incorrect.”

Additional reporting by Haley Lerner