BOSTON — The Yankees head to Fenway Park for the first time this season in less than ideal shape.

They’ve lost players to the disabled list, just dropped a series in The Bronx to the Orioles and have seen their newest star, Giancarlo Stanton, open more eyes with his strikeouts than his homers.

And now, they’ll face a red-hot Red Sox team that will have Chris Sale on the mound for the series opener.

“It was definitely a tough weekend,’’ Dellin Betances said Sunday. “We lost a lot of players. We had to pitch a lot of innings, but this team has fought back.”

That’s been true in the past, but this will be the Yankees’ first true test of the 2018 season, with the hosts carrying an MLB-best 8-1 record into the series.

“I’m aware they’re 8-1,” general manager Brian Cashman said Monday. “I’d rather we were 8-1.”

Boston’s record is in part due to them opening against Tampa Bay and Miami, who have four wins between them. The Yankees are 5-5 and have been hobbled by injuries.

“They’re all important,’’ Cashman said of the Boston series. “We just lost three of four to a team that’s not Boston.”

Still, they can put that ugly weekend behind them by beating their AL East rivals — and presumptive main competition in the division this season.

To do so, the Yankees will probably need more from Stanton than the slugger provided in a first homestand that didn’t come close to following the script of him making easy work of the homer-friendly Stadium.

Instead, Stanton went 3-for-28 with a homer and 16 strikeouts — including the first two five-strikeout games of his professional career. And he also heard plenty of boos from the home crowd.

Cashman didn’t put much stock into Stanton’s rough start or the added pressure of playing in The Bronx.

“I don’t think New York had anything to do with it,” Cashman said. “Slumps are part of the game. It’s frustrating for any player to go through it, but he’s battle-tested.”

And the GM doesn’t expect those problems to linger.

“It was a rough weekend for him,” Cashman said. “That will be in the past soon enough. He’s been through rough patches before and come through them. He’ll carry his teammates at some point this season.”

Tuesday would be a good place to start, but he will face a tough task against Sale, who led the majors with 308 strikeouts last season.

Stanton has played only three games in Boston, where the Marlins were swept in 2012; Stanton went 3-for-9 with a homer.

Betances believes being in enemy territory may help his new teammate.

“You have to feed off that energy,’’ the right-hander said. “You saw what he was able to do in the first game in Toronto [when Stanton homered twice]. That was an intense environment. I think he’ll handle it well. Everything’s gonna be all right. He’s a big bat. Sometimes guys like that, they go through bumps here and there. His swing won’t be quiet for long.”

CC Sabathia, one of the players the Yankees lost to the DL over the weekend, said he hopes Stanton can use the next three games as a springboard for the rest of the season.

“If you use this atmosphere the right way, it could help you for playoff games in the future,’’ Sabathia said. “That’s what I did in ’09. I treated my first games against the Red Sox as a playoff game and it got me ready for the postseason.”

Of course, the Yankees have to get to October before they can worry about how Stanton will react to his first postseason.

The spotlight on Stanton’s rough start will be significantly intensified if it continues against the Red Sox.

And Aaron Judge has struggled so far in his career in Boston.

In nine career games at Fenway, Judge is 3-for-36 with one homer, six walks and 14 strikeouts. His OPS of .399 is by far his worst at any ballpark.

“I feel like I see the ball well there,” Judge said. “They’ve got great pitching. … It’s a hostile environment, but something is different in the air. I enjoy it. I think we’re gonna be fine.”