Hillsborough Avenue in Tampa could be closed until at least mid-afternoon following a multi-vehicle crash near Seminole Heights on Monday morning.

The crash occurred just hours after two other crashes closed lanes a block away, at N 11th Street, and on Sligh Avenue.

Tampa police say the most recent crash occurred before 11 a.m.

Hillsborough Avenue is closed in both directions between Nebraska Avenue and N 12th Street, police said.

Two people were hospitalized with serious injuries, police said.

Crews are on the scene, and the road could be closed for up to five hours while cleanup continues, police said.

Drivers can use East Hanna or East Osborne avenues as alternates.

The earlier crash resulted in an overturned truck blocking eastbound and westbound traffic just east of Interstate 275, police said.

Also early Monday morning, traffic was shut down on Sligh Avenue at N Navin Avenue after a truck hit a pole, resulting in a downed power line. Navin Avenue is west of I-275, between Central and Florida avenues.

Stay with tampabay.com for updates.