Play video content EXCLUSIVE

Hillary Clinton got the George Bush treatment in Vegas Thursday -- an unidentified woman threw a shoe at the former Secretary of State during a speech ... and TMZ has obtained crazy video of the incident.

Clinton was speaking at Mandalay Bay for the Institute of Scrap Recycling Industries when the assailant threw the shoe at her.

Watch the video to see what happens -- Clinton dodges it like a champ and then has some hilarious words for the audience.

The shoe thrower was escorted out of the hotel immediately -- and law enforcement sources tell us, she's currently in custody with the Secret Service.