Most common words used in a pathology report is listed below. The terms below pertains to the most commonly reported types of breast pathology. For an extended list please visit my glossary page by clicking on the link or for rare forms of breast pathology please visit the NCI Dictionary by clicking this link…..

Gross description, Initial description of all human specimens provided to the pathologist, the description is provided without the aid of the microscope

Microscopic description, Refer to microscopic examination of the most important parts of the specimen provided.

Special tests aka breast cancer profile, This usually refer to other parameters such as Estrogen Receptor, Progesterone Receptor, and HER2.

Final diagnosis, This is the concluding paragraph that summarizes the most important finding in a pathology report.

Benign, Not cancerous. Benign tumors can grow locally but can not destroy nearby tissues and spread to other parts of the body.

Malignant, Cancerous. Malignant tumors can invade and destroy nearby tissue and spread to other parts of the body.

Non-invasive. Describes specific histology such DCIS which is not capable of distant spread.

Invasive, Describes cancerous histology which does have the potential of distant spread.

DCIS, ductal carcinoma in situ, cancer arising from the duct, and not capable of spreading.

LCIS, lobular carcinoma in situ, cancer arising from the lobule, and not capable of spreading.

IDC, invasive (capable of spreading) ductal cancer

ILC, invasive (capable of spreading) lobular cancer

Grade 1, histologic grading of cancer of least deviation from normal cells.

Grade 2, histologic grading of cancer of intermediate deviation from normal cells.

Grade 3, histologic grading of cancer of highest deviation from normal cells.

Margins, the layer of healthy tissues not affected by cancer.

Estrogen receptor, Estrogen receptors (ERs) are a group of proteins found inside and on cells. They are receptors that are activated by the hormone estrogen (17β-estradiol).

Progesterone receptor, a protein found inside cells. It is activated by the steroid hormone progesterone.

Allred score, a scoring procedure to determine estrogen receptor positivity

HER2, Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients

IHC, immunohistochemistry, a method of histologic examination of tissue utilizing specific immune antibodies. When utilized to detect HER2, the result will come out as,

+1, meaning it is negative for HER2

+2, meaning it is borderline for HER2, and other tests need to be done.

+3, meaning it is positive for HER2

FISH, Fluorescence in situ hybridization (FISH) is a kind of cytogenetic technique which uses fluorescent probes binding parts of the chromosome to show a high degree of sequence complementarity.

Ki-67, a protein, measures the aggressiveness of breast cancer.

S-phase fraction, A measure of the percentage of cells in a tumor that is in the phase of the cell cycle during which DNA is synthesized. The S-phase fraction may be used with the proliferative index to give a complete understanding of how fast a tumor is growing.

Lymphovascular invasion, tumor cells in the breast cancer tissue is advancing and seen in lymph vessels and blood vessels

Lymph node involvement, breast cancer cells seen in the lymph nodes.

Lymph node micro-invasive disease, breast cancer cells seen in the lymph nodes, but at a very small area.

BRCA1 and BRCA2, these are rare abnormal genes underlying hereditary breast-ovarian cancer syndrome, other genes that occur with lesser frequency include ATM, BRIP1, CHEK2, PALB2, PTEN, TP53. Please note that genetic testing for such gene is not the pathology report, genetic testing is not routinely done on each patient, and it is discussed under genetic screening here and for more details here.