Tame Impala frontman Kevin Parker and The Waifs' Donna Simpson were among musicians amplifying a chorus of opposition to the state government's Roe 8 road project on Monday.

They joined local bands Koi Child, POW! Negro and Grace Barbé on the line-up for Live! In The Wetlands, the latest community effort to save the Beeliar Wetlands, which are in the path of Roe 8.

Thousands were expected to show up for the concert, scheduled to continue all afternoon at Manning Park Sound Shell.

"Many of the people involved in opposing this incredibly destructive road to nowhere are ordinary families who just want to do their bit," organiser Danielle Lake, from Hamilton Hill Community Group, said.