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Fabric nightclub is today facing closure after four drug-related deaths at the venue.

Police have called for a review of its licence, saying that over the past three years, eight people have collapsed, four of whom died, at the Farringdon club after taking MDMA, ecstasy and other drugs.

In the last incident in September, an 18-year-old girl fell ill and later died in hospital after buying MDMA inside the venue — twice voted the world’s best club.

Islington council’s licensing committee is due to review Fabric’s licence tonight.

In a police report submitted to the committee, Pc Steven Harrington said: “It attracts clientele from all over Europe and it would seem that the immaturity or lifestyle of these patrons leads to them becoming actively involved in the taking of illegal drugs and this could account for the disproportionate and wholly unacceptable number of deaths and near death incidents at the venue.”

Stripping Fabric of its licence is being “seriously considered”, the police said. They are demanding the club increases security, including using sniffer dogs. Police said Fabric is one of the capital’s most troublesome clubs, with 12 drug possession or dealing offences for MDMA, ecstasy and Ketamine recorded between April and October this year.

Tonight’s licence review has sparked floods of letters from members of the public, both for and against closure.

One local resident described watching a group of men “out of their box on something more than alcohol” trying to climb fences. But another neighbour wrote: “Keep it open... this is the funkyness of the area we embraced.”

Famous for house and techno nights, Fabric has been crowned best club in the world twice by DJ Magazine.

A spokesman for Fabric declined to comment.