Scientists have discovered the precise brain mechanism that causes the body to hold onto fat, raising hopes of a cure for obesity.

For the first time, lab trials have explained how the brain’s ability to sense insulin in the body, levels of which are raised after a meal, is coordinated with expending or conserving energy.

Researchers at Monash University in Australia have described the findings as “very exciting”, and said they highlight targets for potential fat-inhibiting medicines for people who cannot help putting on weight.