The combination of photodynamic therapy and CO 2 laser usage can give full play to their own respective superiority.

No recurrence was found after 6-month follow-up in 6 cases, and HPV detection for all was changed from positive to negative by PCR.

We cured a series of CA grown on cervix, urethra, urinary meatus, vulva, crissum and anal canal with treatment of CO 2 laser combined PDT.

Abstract

Background Condyloma acuminatum(CA) is a venereal disease associated with a high rate of recurrence due to the rapid replication and subtle immune escape mechanism of Human Papillomavirus(HPV). Topical CO 2 laser can remove verruca accurately. Photodynamic therapy with 5-aminolevulinic acid(PDT-ALA) is also an effective therapy which targets on HPV infected sites. Some studies demonstrate that when combined with use of CO 2 lasers, photodynamic therapy can become more effective.

Methods We attempted to clinically cure a series of CA grown on cervix, urethra, urinary meatus, vulva, crissum and anal canal with treatment of topical CO 2 laser combined with ALA photodynamic therapy and report herein 6 cases.

Results Topical CO 2 laser combined photodynamic therapy for CA achieved a complete response after 3 courses of treatment. No recurrence was found after 6-month follow-up in 6 cases, and the HPV PCR detection for all was changed from positive to negative.