Hours after three Republican senators including John McCain dealt a crushing blow to President Donald Trump's hopes of repealing Obamacare, at least one political operative claimed the Trump presidency "is effectively over."

Sen. Ted Cruz's former campaign manager Rick Tyler made the stunning declaration during an appearance on MSNBC's Morning Joe on Friday.

"I think this presidency is effectively over," Tyler told co-host Mika Brzezinski.

"If you look back to different presidencies, you look at Bill Clinton," he continued. "He had a rough first two years, very difficult two years. But after Oklahoma City he was able to regain his footing and become presidential until he slipped on a blue dress."

"But saying that aside, this president cannot change. Nothing about his behavior tells me, since the beginning of this process, that he was going to change," he added. "If he cannot change and he cannot become presidential and he cannot convince the majority of the American people to enact some legislative agenda that he wants passed, his presidency, legislatively, is effectively over."

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Tyler was forced to resign from the Cruz campaign in early 2016 after circulating a false story about fellow Republican presidential hopeful Marco Rubio. Before working with Cruz, who challenged Trump longer than anyone else in the Republican Party and even withheld his support until after the convention, Tyler worked for former House Speaker Newt Gingrich.

Fellow MSNBC panelist Donny Deustch agreed with Tyler's assessment, chiming in to claim that the failure to pass health care legislation proves Trump's "incompetence."

"He never understood the job of pushing legislation through," Deustch added.

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