A 37-year-old woman with a history of IV heroin use crushed a whole black widow spider, mixed it in 10 mL of distilled water, and injected the mixture intravenously. One hour later she presented to the emergency department complaining of severe, generalized muscle pain and cramping, mainly affecting her abdomen, thighs, and back, and of a headache and anxiety. She stated that she had given herself the injection with the intent of getting a high, and she denied suicidal ideation.