Sen. Susan Collins delivered the likely final blow to the Senate Republicans’ latest effort to repeal and replace the 2010 health care law.

“Sweeping reforms to our health care system and to Medicaid can’t be done well in a compressed time frame, especially when the actual bill is a moving target. Today, we find out that there is now a fourth version of the Graham-Cassidy proposal, which is as deeply flawed as the previous iterations,” the Maine Republican said in a statement of the effort spearheaded by Sens. Lindsey Graham of South Carolina and Bill Cassidy of Louisiana.

“The fact that a new version of this bill was released the very week we are supposed to vote compounds the problem,” she added.

Collins became the third GOP vote in the “no” column, meaning Republicans cannot adopt the Graham-Cassidy measure even with the help of Vice President Mike Pence. Arizona Sen. John McCain and Kentucky Sen. Rand Paul are also opposed.

While Collins had been leaning against the proposal for days, she withheld formal judgment until after a bare-bones analysis from the Congressional Budget Office on Monday showed millions more would be uninsured than under the current law.