A HOMICIDE investigation has been launched after a man was fatally stabbed north of Brisbane.

Emergency services were called to Blyth Rd at Murrumba Downs about 5.45am to find a man lying in the middle of the road with “significant injuries”.

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He died at the scene and a crime scene has been declared.

media_camera Inspector Steve Flori talks to media at the scene of the incident.

Police now believe the man was in a car prior to his death.

A manhunt us now underway for the attacker, who police say is known to the victim.

Investigators have spent the day scouring the area, looking for evidence.

Officers were joined by SES in the search.

A weapon is yet to be located.

Speaking from the scene, Inspector Steve Flori said the man was with a woman at the time of the stabbing.

She phoned police and was hysterical.

“That woman is uninjured however she is extremely distressed,” he said.

“We are still trying to find out exactly what’s happened but I can say that we believe another party was involved.

“We have launched a homicide investigation.”

media_camera The crime scene on Blyth St, Murrumba Downs. Picture: Annette Dew

The man has yet to be formally identified and the relationship between he and the woman is unknown.

“There is some disparity between their ages so whether they are friends … whether they were just together is still a mystery.”

The man is believed to be about 40-years-old.

media_camera Police search the scene of the stabbing for evidence. Picture: Annette Dew

Police have taken the 19-year-old woman back to a station in an attempt to calm her down.

It’s believed the man was still alive when the woman called police.

It took four minutes for officers to arrive, but when they did the man had already died.

Emily Nott, who lives in the Complex behind where the body was found, said she heard a woman screaming loudly this morning.

media_camera Neighbours said they woke early this morning when they heard the 19-year-old woman screaming. Picture: Jacob Miley

After hearing the screams, she went to the street to investigate.

“I saw the body, the tarp and lots of police and a crying lady. She was really distraught and I couldn’t even imagine what she’s going through,” she said.

Ms Nott said she didn’t recognise the woman.

media_camera A forensic officer at the scene. Picture: Annette Dew

Another man, Ian Grisan, also heard loud screaming, but just thought it was coming from next door and thought nothing of it.

About 15 minutes later he said he tried to drive of the complex, but was told to return to his property.

“I drove out and saw the ambulance, the police car was out there. The cops said turn back, go into your house so I did.

“I went back half an hour later and someone said there had been a fatality.”

media_camera The street will remain closed while police do their work. Picture: Queensland Police Service

Blyth St will remain closed for some time while scientific officers and detectives go about their work.

Police do not believe it was a random attack and there is no immediate threat to the public.