Former Vice President Joe Biden Joe BidenPelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Hillicon Valley: Subpoenas for Facebook, Google and Twitter on the cards | Wray rebuffs mail-in voting conspiracies | Reps. raise mass surveillance concerns Fox News poll: Biden ahead of Trump in Nevada, Pennsylvania and Ohio MORE and Sen. Kamala Harris Kamala HarrisHundreds of lawyers from nation's oldest African American sorority join effort to fight voter suppression Biden picks up endorsement from progressive climate group 350 Action 3 reasons why Biden is misreading the politics of court packing MORE (D-Calif.) were center stage in Detroit on the second night of the Democratic presidential primary debates — and it got ugly in a hurry.

Here are five takeaways from a brutal night of intraparty fighting among Democrats in the Motor City on Wednesday:

No clear winner emerges after an ugly night

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This was not the debate that Democrats were hoping for.

"The person that's enjoying this debate most right now is Donald Trump Donald John TrumpSteele Dossier sub-source was subject of FBI counterintelligence probe Pelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Trump 'no longer angry' at Romney because of Supreme Court stance MORE, as we pit Democrats against each,” Sen. Cory Booker Cory Anthony Booker3 reasons why Biden is misreading the politics of court packing Bipartisan praise pours in after Ginsburg's death DHS opens probe into allegations at Georgia ICE facility MORE (D-N.J.) said amid an extended and nasty fight between the candidates over their health care plans.

“Fact check: True,” Trump campaign spokesman Tim Murtaugh responded over Twitter.

The attacks on Biden began during the opening remarks and escalated from there as he sustained shots on everything, including his record on civil rights, women’s rights, his health care and environmental plans and the Obama administration's record on deportations.

After catapulting into the top tier of candidates following the first debate, Harris was in everyone’s crosshairs over a health care plan that tries to find a middle ground on "Medicare for All."

And Harris’s record as attorney general of California become an issue for her after Rep. Tulsi Gabbard Tulsi GabbardRepublicans call on DOJ to investigate Netflix over 'Cuties' film Hispanic Caucus campaign arm endorses slate of non-Hispanic candidates Gabbard says she 'was not invited to participate in any way' in Democratic convention MORE (D-Hawaii) unsparingly characterized the Harris state Justice Department as craven, racist and corrupt.

The split between the centrists and liberals on Tuesday night was back on full display once again on Wednesday, with moderates such as Sen. Michael Bennet Michael Farrand BennetOVERNIGHT ENERGY: House Democrats tee up vote on climate-focused energy bill next week | EPA reappoints controversial leader to air quality advisory committee | Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' Senate Democrats demand White House fire controversial head of public lands agency Next crisis, keep people working and give them raises MORE (D-Colo.) pleading with Democrats to not run too far to the left.

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There were times during the debate, such as during the Gabbard and Harris exchange, where the candidates genuinely seemed to not like each other.

That’s a sign that the Democratic primary is about to get a lot nastier with 10 more debates and months to go before votes are cast.

Candidates pile on Biden

Biden was everybody’s main target on Wednesday night, and each of his nine rivals onstage took a shot at him at some point with cutting lines they hoped would leave a mark, as Harris did at the first debate.

The first candidate to speak on Wednesday night was New York City Mayor Bill de Blasio Bill de BlasioOVERNIGHT ENERGY: California seeks to sell only electric cars by 2035 | EPA threatens to close New York City office after Trump threats to 'anarchist' cities | House energy package sparks criticism from left and right EPA threatens to close New York City office after Trump threats to 'anarchist' cities New Year's Eve in Times Square to be largely virtual amid pandemic MORE (D), who promptly ripped Biden for “telling wealthy donors nothing will fundamentally change if he were president.”

From there it was open season on the front-runner, who was squeezed by his two fiercest critics in the race, Harris and Booker.

Harris re-upped the federal busing attack that was so effective for her in the first Democratic debates in Miami, saying that if the segregationist senators Biden worked with decades ago had their way he never would have been the vice president for the nation’s first black president.

Booker hammered Biden for his record on civil rights, blaming him for being the architect of what he described as a racist criminal justice system that has incarcerated scores of young racial minorities.

Biden also absorbed attacks from Washington Gov. Jay Inslee Jay Robert InsleeBarr asked prosecutors to explore charging Seattle mayor over protest zone: report Bottom line Oregon senator says Trump's blame on 'forest management' for wildfires is 'just a big and devastating lie' MORE (D) for his climate plan.

And he took heat from former Housing and Urban Development Secretary Julián Castro for refusing to support the decriminalization of illegal border crossings.

Biden told Castro that he never brought up his concerns when they were in the Obama administration.

“One of us has learned the lessons of the past and one of us hasn’t,” Castro shot back.

Biden seemed tongue-tied at times but never completely off guard or slow to respond, as he seemed to be at the first debates.

There were a few instances where he was quick on his feet, as he memorably dismissed de Blasio’s influence over the future of the Democratic Party.

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“We hope you’re a part of it,” Biden said.

And he shook away an attack from Sen. Kirsten Gillibrand Kirsten GillibrandSunday shows preview: Justice Ginsburg dies, sparking partisan battle over vacancy before election Suburban moms are going to decide the 2020 election Jon Stewart urges Congress to help veterans exposed to burn pits MORE (D-N.Y.), who tried to portray him as an opponent of women’s rights.

“I don’t understand what’s happened other than now you’re running for president,” Biden said.

Rivals chip away at Harris

Harris was the unquestioned breakout candidate from the Miami debates last month after her brutal exchange with Biden on federal busing.

But her performance in Detroit was much more muddled and mixed, and she sustained cutting attacks over her record as attorney general in California and questions about whether she’s flip-flopped on key issues.

The first hour of the debate was centered almost exclusively on health care, with Harris’s proposed Medicare for All plan the centerpiece of conversation.

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Harris has been under scrutiny for being unclear on whether her plan would result in a tax increase on the middle class and whether she would abolish private insurance. Critics say Harris’s plan is impossible to implement without doing both of those things, and the subject matter did not seem to be in her wheelhouse.

Harris fired back, accusing her rivals of using “Republican talking points,” but the sustained attacks from Biden and Bennet were effective and kept her on the defensive.

But perhaps the worst moment for Harris came during an exchange with Gabbard, who signaled that she’d go hard after Harris this week when she said the California Democrat should not be put in charge of the military.

Gabbard accused Harris of locking up scores of racial minorities for low-level drug offenses, accused her of hiding evidence that would free an innocent man on death row and said she kept people imprisoned for longer sentences to use them as cheap prison labor.

“The people who suffered under your reign as prosecutor, you owe them an apology,” Gabbard said.

Harris had good moments as well. She repeatedly stood up to Biden and questioned his own decades long record, but she spent much of the night on the defensive and turned in a choppier performance.

Booker stands out with viral zingers

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The debates have been a reminder for Democrats that the New Jersey senator can be a charismatic and effective communicator, even if he hasn’t had the breakout moment he craves.

It’s unclear whether Booker will get that coming out of Detroit, but he brought zingers that earned him internet fame, which is part of the equation for any candidate hoping to stand out.

Booker’s best line came at the expense of Biden, who had just criticized Booker’s civil rights record as mayor of Newark, N.J.

“There’s a saying in my community: You’re dipping into the Kool-Aid and you don’t even know the flavor,” Booker said.

That line was Kool-Aid approved, earning an “Oh yeah” from Kool-Aid’s fruit punch mascot on Twitter.

Later, Booker landed a punch, telling Biden “you can’t have it both ways” when it comes to Obama’s legacy.

“You invoke President Obama more than anybody in this campaign,” he said. “You can’t do it when it’s convenient and then dodge it when it’s not.”

Democrats were united on health care in 2018; now they’re terribly divided

Democrats regained the House in 2018 in part by running on a message that they would protect ObamaCare from the GOP’s repeal and replace efforts.

In 2020, the issue of health care is tearing the party apart and has emerged as the central animating issue dividing centrist Democrats from liberal progressives.

On both nights of the Detroit debates, health care dominated for at least the first half hour, with the candidates exchanging nasty jabs about the motives of their rivals.

The progressives, led by Sens. Bernie Sanders Bernie SandersThe Hill's Campaign Report: Trump faces backlash after not committing to peaceful transition of power Bernie Sanders: 'This is an election between Donald Trump and democracy' The Hill's 12:30 Report: Trump stokes fears over November election outcome MORE (I-Vt.) and Elizabeth Warren Elizabeth WarrenHillicon Valley: Subpoenas for Facebook, Google and Twitter on the cards | Wray rebuffs mail-in voting conspiracies | Reps. raise mass surveillance concerns On The Money: Anxious Democrats push for vote on COVID-19 aid | Pelosi, Mnuchin ready to restart talks | Weekly jobless claims increase | Senate treads close to shutdown deadline Democratic senators ask inspector general to investigate IRS use of location tracking service MORE (D-Mass.), say the party must fully embrace a Medicare for All plan that raises taxes and eliminates private insurers, but that would also eliminate deductibles and copays and would ensure everyone is covered.

Mainstream Democrats say the astronomical cost of Medicare for All would bankrupt the government and warn that taking away people’s current plans is a surefire election loser.

Those trying to stake out a middle ground, such as Harris, are getting hammered by both the centrists, for not being honest about the implications of a health care overhaul, and by the left, for not going far enough.

Biden is staking his claim on ObamaCare, betting that sticking close to the popular law and the popular former president will help him weather the debate.