Former Vice President Joe Biden Joe BidenSenate Republicans face tough decision on replacing Ginsburg What Senate Republicans have said about election-year Supreme Court vacancies Biden says Ginsburg successor should be picked by candidate who wins on Nov. 3 MORE hit back Wednesday at a campaign ad from former New York City Mayor Michael Bloomberg Michael BloombergTop Democratic super PAC launches Florida ad blitz after Bloomberg donation The Hill's 12:30 Report - Presented by Facebook - Latest with the COVID-19 relief bill negotiations The Memo: 2020 is all about winning Florida MORE highlighting Biden’s previous praise of his fellow Democratic presidential candidate.

“The best way to predict the future is to create it. I don’t know anybody I’ve worked with in my career, and I’ve been hanging around a long time, who does more to create the future than you, Mike,” Biden says in the clip shown in the Bloomberg ad.

“Mike Bloomberg transformed the city of New York into a global leader on public health and environmental stewardship. Mike Bloomberg transformed the city of New York into a global leader on public health and environmental stewardship. While others talked about climate change, Mike took action,” he continues.

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In a tweet accompanying the video, Bloomberg's campaign said, "Joe Biden has dedicated his life to this country. As a senator, and as a vice president, he has always stood by the side of great men. We are honored to have Joe’s support."

“I don’t endorse Republicans,” Biden tweeted in response on Wednesday. Bloomberg won his first term as mayor running as a Republican in New York and spoke at the 2004 Republican National Convention, later switching his affiliation to independent.

I don’t endorse Republicans. https://t.co/uQMjLdxHA3 — Joe Biden (Text Join to 30330) (@JoeBiden) February 19, 2020

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The back and forth comes ahead of Wednesday evening’s Democratic debate in Nevada, the first where the former mayor has qualified to take the stage.

Numerous candidates have taken aim at Bloomberg as he gains steam in the polls, with Sens. Elizabeth Warren Elizabeth WarrenBiden's fiscal program: What is the likely market impact? Warren, Schumer introduce plan for next president to cancel ,000 in student debt The Hill's 12:30 Report - Presented by Facebook - Don't expect a government check anytime soon MORE (D-Mass.) and Bernie Sanders Bernie SandersKenosha will be a good bellwether in 2020 Biden's fiscal program: What is the likely market impact? McConnell accuses Democrats of sowing division by 'downplaying progress' on election security MORE (I-Vt.) accusing him of trying to buy the election and billionaire Tom Steyer Tom SteyerTV ads favored Biden 2-1 in past month Inslee calls Biden climate plan 'perfect for the moment' OVERNIGHT ENERGY: Trump administration finalizes plan to open up Alaska wildlife refuge to drilling | California finalizes fuel efficiency deal with five automakers, undercutting Trump | Democrats use vulnerable GOP senators to get rare win on environment MORE highlighting his support for stop-and-frisk policing as mayor.

Biden also reportedly took issue with Bloomberg’s prominent usage of former President Obama in his advertising, telling a attendees at a New York fundraiser last week that “the advertising I’ve seen, you’d think that Mike was Barack’s vice president."