In vitro fertilization (IVF) clinics specialize in obtaining, storing, and culturing sperm and eggs from donors to generate live embryos. Because they handle large quantities of human-derived primary cells, these labs must be tightly regulated. The guidelines state that every device, including those used to cryogenically store sperm and eggs, must be clearly and permanently labeled with patient identification codes and the date the samples were taken. Many labs will also require that their devices have low levels of volatile organic compounds (VOCs).

Labeling IVF cryo straws for long-term cryogenic storage

IVF straws are typically used to store eggs, sperm, and embryos, which undergo a process called vitrification. Vitrification is performed by rapidly freezing the cells in liquid nitrogen with the help of a cryoprotectant solution, usually composed of ethylene glycol, glycerol, or propylene glycol. As such, these straws require wrap-around labels with a strong cryo-adhesive to easily conform to the small diameter of the straws and to remain permanently attached during snap-freezing and cryogenic storage. Using the wrong type of label on vitrification straws will result in the label losing adhesion and slipping off the straw, as most adhesives do not stick well when exposed to vitrification or cryoprotectant solution. Given the importance of the information inscribed on the label, the ink used to print the labels should also not smudge or fade during cryogenic storage. The ideal solution to avoid these potential hazards requires using a cryogenic label specially designed for IVF vitrification straws alongside a thermal-transfer printer that uses a smudge and alcohol-proof resin ribbon, which will allow you to avoid accidental removal of the label and incidental smudging. Labels specially made for IVF procedures must also contain relatively low levels of VOCs; however, the exact limit varies depending on the testing standards of the lab using them.