Transcript for Clinton on Defense After Trump Attacks Clinton Foundation, Health

Donald Trump is opening up new lines of attack hitting Hillary Clinton for alleged connections between the Clinton foundation and the state department and ramping up his questions about her health. Clinton meanwhile is firing back. And as you're about to see, the political fireworks are not just flying between the candidates. Here's ABC's David Wright. Reporter: Tonight Hillary Clinton faces an attack on two fronts. Donald Trump is hammering the Clinton foundation for what he says is a conflict of interest. It is impossible to figure out where the Clinton foundation ends and the state department begins. Reporter: While also questioning Clinton's physical fitness to serve. She also lacks the mental and physical stamina. Reporter: Today Hillary Clinton did her best to shrug it off in the photo booth with Justin Timberlake and Jessica biel at a $33,000 a ticket fund-raiser. Tonight her campaign is on the defensive. Trump even calling for the appointment of a special prosecutors. Quickly or impartially investigate Hillary Clinton's new crimes which happen all the time. Reporter: The Clinton foundation controversy stems from a series of e-mails from top Clinton aides released by the conservative group judicial watch which says that the e-mails reveal a pattern of big-money donors getting streamlined access to the secretary of state's office. For instance, the crown prince of Bahrain got a meeting with Clinton, only after exhausting all the Normal channels, and turning to the Clinton foundation for help. His government had given between $50,000 and $100,000 to the foundation. An executive from the foundation stepped in. Good friend of ours, he noted in an e-mail to a top Clinton aide. Within 48 hours the meeting was set. I'd like to invite to the stage Raj Fernando -- Reporter: Rajiv Fernando was a big donor who somehow got a state department appointment to a sensitive international security board, even though Fernando had no known experience in that area. My colleague Brian Ross first dug into his story, Fernando went after his cameras and threatened to have Brian arrested. Have you arrested for asking questions. Reporter: Eventually Fernando resigned from the board but Brian's team caught up with him again at the democratic national convention. Rajiv Fernando, Clinton superdelegate. I'm just trying to help secretary Clinton get elected. Reporter: Today the Clinton campaign pushed back on these and other stories connecting the dots between the donors and the secretary's daily diary claiming reporters had cherry-picked a limited subset of secretary Clinton's schedule to give a distorted portrayal of how often she crossed paths with individuals connected to charitable donations to the Clinton foundation. To help us hash it out, we invited two of the sharpest tongues in both parties to P.J. Clarke's, the conservative Ann poulter, the raging caging James Carville. Both of whom have new books out. "In trump we trust." His, "We're still right, they're still wrong: The democrats' case for 2016." A big question is Washington politicians bought and sold by special interests. Let's stipulate the Clintons have cashed in on the presidency like nobody else. The only former president -- not the only former president who gave speeches. They've gotten a lot more at it. They're more successful at it. This week in answer to a lot of criticism they finally said, if Hillary Clinton wins in November, no more foreign contributions no more corporate contributions. That promise still gives the foreign despots and the corporations a few more months for their checks to clear. Isn't it a bit late? First of all, you're going to win. The pressure's going to win this fight. They will shut the Clinton foundation down, it will be a great try yul . Now 11 million people that get their HIV drugs, they're not going to fare so well. The potential is there. You have to concede the appearance of a conflict when donors to the Clinton foundation got special access in terms of the secretary of state. The Clintons have never taken a nickel out of the Clinton foundation. So how does it profit them? Not out of the Clinton foundation but they get money into the Clinton foundation, oh by the way, my husband gives a great speech and then bill Clinton gets hired to give $600,000 speech. Reporter: The fight over the foundation is just one prong of attack this week. The trump and surrogates, Hillary's health a talking point. I think Hillary's tired. Reporter: The republicans publicly and repeatedly raising doubts. I'm not saying that she's had a stroke or anything like that. But this is not the woman that we're used to seeing that would come at you and get in your grille. Reporter: Republicans have pointed to this awkward head wag at a muffin shop in June suggesting Clinton might have been having a seizure. Reporters who were there say they saw no such thing that the best they could tell, she was merely being evasive. Republicans point to Clinton's persistent cough. Noted her stumbling on the stairs of her plane. So last night on jimmy Kimmel -- Are you in good health? Well, this has become one of their themes. You take my pulse while I'm talking to you. Jimmy: Oh my god, there's nothing there! There's nothing there, what can I say. Reporter: Clinton laughed it off. In October "The national enquirer" said I would be dead in six months. With every breath I take -- You have a new lease on life. Reality check. Trump is 70. Clinton 68. Trump would be the oldest president ever elected. Clinton would be second-oldest. Second only to Ronald Reagan, who was a few months oldre than she is when he was elected in 1980. I will not make age an issue of this campaign. I am not going to exploit, for political purposes, my opponent's youth and inexperience. Both these candidates refused to release their full medical records. Last year Clinton's campaign released a two-page letter from her doctor concluding she's in excellent physical condition and fit to serve as president of the United States. Trump released just a brief note from his gastroenterologist full of trumpy superlatives describing his test results as astonishingly excellent, adding that trump would be the healthiest individual ever elected to the presidency. Go figure. I don't think we need to see about trump's health, I've never seen anyone so healthy, I just try to follow him online and I'm exhausted, giving a speech every day. She seems to have some trouble. Maybe we can find common ground and push for total transparency. She should release her health records, he should release his taxes. If the idea is he can give a longer speech? I go around the country, I do a lot of stuff. Every time people say, I wish these politicians would give a longer speech, that's what this country really, really needs is a longer speech. That's not what we wanted, it's a sign of energy. Reporter: This is already an awfully ugly election. Win or lose, does either of you have any hope that the day after election day, whoever wins is going to be able to get anything done? Sure. This is one of the very clever things I think about the trump campaign. An awful lot of the things he's talking about, frankly, they are executive branch powers. Renegotiating trade deals. Putting limits on certain types of immigrants coming in. Building a wall. None of that even needs congressional approval. I think this is going to break a jail. Because voters have very clear chois. One candidate says he's going to make America great again, he's going to take us back to something. Another candidate talking about moving forward. Reporter: It's not even labor day and already this race is the political equivalent of total war. Hey, if we can get these two to the table, maybe there's hope yet. I'm David Wright for "Nightline" in New York.

This transcript has been automatically generated and may not be 100% accurate.