A PRIEST and two teachers who worked at a West Australian Catholic school for indigenous children in the 1960s have been arrested on multiple child abuse charges.

A 78-year-man, who was a priest at the Wandering Mission and was arrested in Melbourne, has been charged with rape and 12 other offences.

A Perth man, now aged 83, who worked as a teacher at the mission has been charged with 14 offences involving abuse, including rape of five girls who were aged between nine and 13 between 1959 and 2003.

An 82-year-old Perth man is facing seven charges.

WA police said in a statement on Wednesday that the charges follow investigations which stem from the Royal Commission into Institutional Child Sexual Offences.