The Napthine Government is heading for a crushing loss at next month's Victorian election, according to the latest opinion poll.

The IPSOS poll of more than 1,400 people, published in The Age newspaper, found the Coalition trailing Labor 44 per cent to 56 per cent on a two-party preferred basis.

If the result was replicated on 29 November Labor would win government, gaining as many as 10 seats depending on how preferences were distributed.

The Coalition's primary vote was on 39 per cent, compared to almost 45 per cent at the 2010 election.

Premier Denis Napthine said polls could not be trusted.

"There's only one poll that counts and that's on 29th of November," he said.

"If you look back four years ago the polls were saying the Brumby government were going to win."

As with other recent polls Dr Napthine remained the preferred premier, leading Daniel Andrews 45 per cent to 36 per cent.

The majority of those polled also believed Labor was the better party to manage health, education, employment, public transport and the environment.

The Coalition was seen as the better party for managing roads, law and order and finances.

There was also good news for the Greens, with the poll finding its primary vote is on 17 per cent, up from 11 per cent at the 2010 election.

The poll was conducted between October 23 and 26.

The IPSOS poll is the latest in a string of bad polls for the Napthine Government but the result was worse than previous polls.