Senate Minority Leader Harry Reid Harry Mason ReidGraham signals support for confirming a Supreme Court nominee this year Trump signals he will move to replace Ginsburg 'without delay' Senate Republicans signal openness to working with Biden MORE (D-Nev.) is throwing a wrench into Hillary Clinton Hillary Diane Rodham ClintonJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Momentum growing among Republicans for Supreme Court vote before Election Day Warning signs flash for Lindsey Graham in South Carolina MORE’s plans for picking a vice presidential candidate, warning any senator from a state with a Republican governor is off limits.

Reid, who wants Democrats to take back the Senate in his final year as leader, said his answer to whether Clinton should pick a running mate who could be replaced in the Senate by a Republican was “hell no.”

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“If we have a Republican governor in any of those states, the answer is not only no, but hell no. I would do whatever I can, and I think most of my Democratic colleagues here would say the same thing," Reid told MSNBC's "AM Joy.” “[I would] yell and scream to stop that.”

The comments mean Reid would be in opposition to Clinton picking Elizabeth Warren Elizabeth WarrenBiden's fiscal program: What is the likely market impact? Warren, Schumer introduce plan for next president to cancel ,000 in student debt The Hill's 12:30 Report - Presented by Facebook - Don't expect a government check anytime soon MORE (Mass.) or Sherrod Brown Sherrod Campbell BrownBipartisan praise pours in after Ginsburg's death Emboldened Democrats haggle over 2021 agenda Hillicon Valley: Russia 'amplifying' concerns around mail-in voting to undermine election | Facebook and Twitter take steps to limit Trump remarks on voting | Facebook to block political ads ahead of election MORE (Ohio), two senators with big progressive fan bases who are on most short lists. It would also be a reason against picking New Jersey Sen. Cory Booker.

Reid offered no hints about who he’d like to see Clinton pick. Virginia Democratic Sens. Tim Kaine Timothy (Tim) Michael KaineBarrett seen as a front-runner for Trump Supreme Court pick Biden promises Democratic senators help in battleground states Second GOP senator to quarantine after exposure to coronavirus MORE and Mark Warner Mark Robert WarnerIntelligence chief says Congress will get some in-person election security briefings Overnight Defense: Trump hosts Israel, UAE, Bahrain for historic signing l Air Force reveals it secretly built and flew new fighter jet l Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' House approves bill to secure internet-connected federal devices against cyber threats MORE, however, have also been seen as under consideration and represent a state with a Democratic governor.

Other names that have been floated include Labor Secretary Tom Perez, Housing and Urban Development Secretary Julián Castro and Colorado Gov. John Hickenlooper.

A Democratic leadership aide said Reid was responding to a specific question and was not offering indication that he would increasingly weigh in on Clinton’s vice presidential pick. Instead, the comments were “purely based” on his wanting to keep GOP governors from being able to make political appointments.

“I wouldn't look too deep into his comments,” the aide told The Hill. “He didn't want Republican governors to be in line to appoint [GOP senators]."

Virginia Gov. Terry McAuliffe, a longtime Clinton insider, has been pushing his state’s senators for months. But many have speculated that Brown or Warren would be stronger picks for Clinton, who may need to find a running mate that excites the liberal base after her bruising primary battle with Sen. Bernie Sanders (I-Vt.). Warren and Brown are beloved by the left, partly for their willingness to oppose trade deals and battle with Wall Street.

Democrats are fighting to regain control of the Senate majority this election cycle. They'll need a net gain of four seats to win back the chamber if they retain the White House and a net gain of five seats to win the Senate back outright.

The 2016 map is titled in favor of Senate Democrats: They are defending 10 Senate seats, compared to 24 for Republicans. While Reid is optimistic that Democrats will win back the upper chamber, a net gain of five seats is an uphill climb.

Warren, Brown and Booker all hail from states with Republican governors. If one of them were picked for vice president and Clinton won the White House, they would need to step down.

That could pave the way for a GOP governor to temporarily appoint a Republican to fill a Senate seat, forcing Democrats to win an extra seat to reclaim the majority.

Brown, who has declined having any interest in joining Clinton on the Democratic ticket, has said that he's worried about allowing John Kasich, Ohio's Republican governor, to fill his seat.

“If I were on the ticket and Hillary were to win, that John Kasich would nominate and would appoint my successor, and that bothers me so,” he told MSNBC's “Hardball” earlier this month.

Reid’s comments aren’t the first time the battle for the Senate has bled over into the presidential election.

In 2008, then-Sen. Joe Biden Joe BidenMomentum growing among Republicans for Supreme Court vote before Election Day Trump expects to nominate woman to replace Ginsburg next week Video of Lindsey Graham arguing against nominating a Supreme Court justice in an election year goes viral MORE, from Delaware, and Sen. Jack Reed John (Jack) Francis ReedWhen 'Buy American' and common sense collide Hillicon Valley: Russia 'amplifying' concerns around mail-in voting to undermine election | Facebook and Twitter take steps to limit Trump remarks on voting | Facebook to block political ads ahead of election Top Democrats press Trump to sanction Russian individuals over 2020 election interference efforts MORE (D-R.I.) were speculated as potential running mates for then-Sen. Barack Obama Barack Hussein ObamaMomentum growing among Republicans for Supreme Court vote before Election Day Warning signs flash for Lindsey Graham in South Carolina Majority of voters say Trump should not nominate a Supreme Court justice: poll MORE.

But Reed faced a major roadblock: who would succeed him. Heading into the 2008 election, Democrats controlled the Senate by a slim 51-49 majority. If Reed had been selected, then-Rhode Island Gov. Don Carcieri, a Republican, likely would have appointed a Republican to fill his seat.

Instead, Obama picked Biden. The move allowed Delaware Gov. Ruth Ann Minner, a Democrat, to appoint Ted Kaufman, a Democrat and former Biden aide, to fill the seat until a special election in 2010.

Reid also pointed out that then-Sen. Lloyd Bentsen (D-Texas) was appointed as Treasury Secretary under Bill Clinton William (Bill) Jefferson ClintonDolly Parton remembers Ginsburg: 'Her voice was soft but her message rang loud' Sunday shows preview: Justice Ginsburg dies, sparking partisan battle over vacancy before election Calls grow for Biden to expand election map in final sprint MORE’s administration. Though Bob Krueger, a Democratic appointee, temporarily succeeded Bentsen, he was beat in a special election by Kay Bailey Hutchison, a Republican.

“We have never recovered from that,” Reid said. “Had we not gone along with that we could still have a Democratic senator from Texas.”