Time to redo the Giants depth chart.

Tight end Evan Engram (knee), cornerback Eli Apple (groin) and linebacker Olivier Vernon (ankle) will not play Sunday against the Saints, according to coach Pat Shurmur.

No. 3 halfback Jonathan Stewart (foot) and No. 3 wide receiver Cody Latimer (knee) also are ruled out. Cornerback Antonio Hamilton (groin) and wide receiver/returner Stacy Coley (hamstring) are listed as "questionable" on the official injury report.

Defensive tackle Damon Harrison was limited in Friday's practice but is expected to play. Linebacker Connor Barwin was a full participant after missing time earlier this week.

The loss of Engram is no surprise given he reportedly suffered a strained MCL against the Texans, when he couldn't finish the game and left the locker room wearing a knee brace.

Vernon will be sidelined for the fourth straight game to open the season, matching the total number of games he missed last season due to injury. He returned to practice on a limited basis earlier in the week but did not participate Friday.

"No setback," Shurmur said. "This was a fast practice with preparation for New Orleans. He's made great progress this week and he's close. He just wasn't quite ready."

The loss of Apple might be the biggest blow given he was playing at a career-high level through three games.

"Definitely disappointed," Apple said. "But I know it's the best thing right now for me and the team. I'm going to be the best teammate I can be on gameday."

Apple said he is "really close" to returning. He was a limited participant in Friday's practice.

"I've got to get faster, back to my normal speed. I'm not there yet," Apple said. "It's going to be a collective type of effort. Everybody is going to have to step up. We're going against a great offense."

Apple cited a wet field as a reason for taking it easier Friday, though the Giants could have moved practice inside if it was a major concern.

"We're going to take the necessary precautions and get ready for next week," Apple said. "I feel good."

In the absence of Engram, the Giants will turn to Rhett Ellison as the starter, with Scott Simonson as the No. 2 tight end and rookie Garrett Dickerson, who was just promoted from the practice squad, set to make his NFL debut.

B.W. Webb will slide from the nickel to outside corner to replace Apple, with Donte Deayon and safety Michael Thomas filling in on the slot. It seems likely defensive backs Kamrin Moore and/or Jordan will be active on gameday for the first time.

The Saints are averaging 428 yards and 34.7 points per game — both top four in the NFL — entering the game against a short-handed Giants defense.

If Coley joins Latimer on the sideline, the Giants will be without their two primary returners, which increases the likelihood of Odell Beckham or Saquon Barkley on special teams.

Shurmur had said Stewart, Latimer and Harrison were dealing with "wear and tear," but two of the three are out. The extent of Harrison's injury is unknown because he has not talked to the media during three of the four regular-season weeks thus far.

Ryan Dunleavy may be reached at rdunleavy@njadvancemedia.com. Follow him on Twitter @rydunleavy. Find our Giants coverage on Facebook.