Signs reading "Stay Home" and "Greetings from Quarantine" hang from an apartment window along Massachusetts Ave in Boston on March 22, 2020. Jessica Rinaldi | Boston Globe | Getty images

A growing list of states is telling residents to stay at home during the coronavirus crisis, as COVID-19 takes hold in the U.S. As of Monday, the virus had infected 41,500 people in the U.S. and killed at least 499, according to Johns Hopkins University. Health officials have said "social distancing" is key to slowing the spread of the virus, leading schools, places of worship and other large gathering spaces to shutter. Here's a round-up of what states announced on Monday:

New Mexico stay-at-home instruction now in effect

Michelle Lujan Grisham, governor of New Mexico, speaks during an interview at her office in Santa Fe, New Mexico, U.S., on Thursday, Aug. 8, 2019. Steven St John/Bloomberg via Getty Images Steven St John | Bloomberg via Getty Images

New Mexico Gov. Michelle Lujan Grisham issued "stay-at-home" instructions late Monday, to take effect Tuesday. Residents should remain in their homes except for outings absolutely necessary for health, safety and welfare, Grisham said in a statement. "The only way for us to stop the spread of this virus is for New Mexicans to stop interacting with each other," Lujan Grisham said. "New Mexicans must be crystal-clear on this point. Right now, every time you leave your house, you are putting yourself, your family and your community at risk." New Mexico Secretary of Health Kathy Kunkel also issued an order closing all non-essential businesses. The public health emergency order requires 100% of the state's non-essential workforce to work from home. It is in effect until April 10. Essential businesses that are allowed to remain open include health-care operations, homeless shelters and grocery stores. As of Tuesday morning, New Mexico has 83 coronavirus cases, according to the New Mexico Department of Health.

State of Washington issues 'stay home, stay healthy' order

Washington State Governor Jay Inslee announces measures to help contain the spread of coronavirus at a press conference on March 11, 2020 in Seattle, Washington. John Moore | Getty Images

The state of Washington on Monday issued a stay at home order effective immediately, Gov. Jay Inslee announced in a series of tweets. The order says Washingtonians must stay at home except for essential activity, which includes grocery shopping, doctor appointments and essential work duty, Inslee said. People can still go outside for a walk, a bike ride or to garden, but they must remain six feet away from others at all times, Inslee said. "This order is enforceable by law, but the legal penalties are not what should convince people to follow these orders," Inslee tweeted. "The real penalty may be the loss of a loved one to COVID-19."

Indiana has 'stay-at-home' executive order

Eric Holcomb, governor of Indiana, in National Harbor, Maryland, U.S., on Thursday, June 21, 2018. Andrew Harrer | Bloomberg via Getty Images

Indiana residents have been ordered to "hunker down" and remain at home, Gov. Eric Holcomb announced Monday. The "stay-at-home" executive order is effective Tuesday at 11:59 pm and ends April 6, but could be extended if the outbreak worsens. "Stay at home unless you're going out on an essential errand or essential work or essential business," Holcomb said at a press briefing Monday. Essential businesses and services include grocery stores, pharmacies, gas stations, police stations, fire stations, hospitals, doctor's offices, health care facilities, garbage pickup, public transit and public service hotlines such as SNAP and HIP 2.0, as well as others, according to a statement from the governor's office. The "Stay order will be enforced by the Indiana State Police and local law enforcement, but not the National Guard. Holcomb also issued an executive order that authorizes the state's Alcohol and Tobacco Commission to suspend the food and beverage licenses of bars and restaurants that still allow sit-down dining. He said these measures are necessary to help stop the outbreak. "Our neighbors and our economy need to see that we're taking steps that will help flatten the curve to ensure our health-care system is able to treat the most vulnerable," Holcomb said. Indiana currently has 259 total positive cases of the coronavirus, according to the Indiana State Department of Health.

Virginia closes certain nonessential businesses

Virginia Governor Ralph Northam speaks with reporters at a press conference at the Governor's mansion on February 2, 2019 in Richmond, Virginia. Alex Edelman | Getty Images

Virginia Gov. Ralph Northam ordered the closure of certain nonessential businesses and banned gatherings of more than 10 people. The order goes into effect Tuesday at 11:59 pm until April 23. Northam also shuttered the state's K-12 schools for the rest of the academic year. "This is an unprecedented situation, and it requires unprecedented actions to protect public health and save lives," Northam said in a statement. Non-essential businesses ordered to be closed include theaters, fitness centers, bowling alleys and hair salons, as well as others. Restaurants and other dining establishments are mandated to close to the public, but can still provide take-out and delivery services. "These restrictions on non-essential businesses will create hardships on the businesses and employees affected," Northam said in a statement. "But they are necessary, and we do not undertake them lightly." Certain retailers that are considered essential are allowed to remain open such as grocery stores, electronics stores, pet stores and laundromats. Virginia currently has 254 reported cases of the coronavirus, according to the Virginia Department of Health.

West Virginia ordered to 'stay at home'

Jim Justice, governor of West Virginia, applauds on stage before participating in a round table discussion on tax reform with U.S. President Donald Trump, not pictured, at the White Sulphur Springs Civic Center in White Sulphur Springs, West Virginia, U.S., on Thursday, April 5, 2018. Luke Sharrett/Bloomberg via Getty Images Luke Sharrett | Bloomberg | Getty Images

West Virginia Gov. Jim Justice issued a "stay at home" order for the entire state on Monday. It will go into effect Tuesday at 8:00 pm. "This order asks West Virginians to stay at home and limit movements outside beyond essential needs," Justice said in a tweet. Only those who provide essential services or are employed by essential businesses can go to work, according to the order. Residents will still be allowed to go to grocery, convenience and warehouse stores, as well as to the pharmacy. They can also bike ride, jog and walk outside as long as they maintain distances of six feet apart from other people. West Virginia has 16 confirmed cases of the coronavirus, according to data gathered by the state.

Maryland closes non-essential businesses

Maryland Governor Larry Hogan enters a press conference where he addressed the coronavirus and the states efforts to battle the virus at the State House in Annapolis, Maryland on March 12, 2020. Michael Robinson Chavez | The Washington Post via Getty Images

Maryland Gov. Larry Hogan enacted an executive order Monday that closes non-essential business, organizations and facilities in the state. The order goes into effect 5:00 pm Monday. Hogan said at a press briefing Monday that he is following federal guidelines in determining which businesses are essential. Maryland currently does not have a stay-at-home order like other states have implemented. "We are not issuing or ordering a shelter-in-place directive or forcing people to stay at home," Hogan said. However, Hogan urged residents to practice social distancing. The state previously banned gatherings of more than 10 people and Hogan admonished residents for holding large gatherings in public places like parks and beaches. "If you are engaged in this kind of activity, you are breaking the law and you are literally endangering the lives of your family, your friends and your fellow citizens," Hogan said. Maryland currently has 288 confirmed coronavirus cases, according to data from the state.

Michigan executive order to 'stay home'

Gretchen Whitmer, Michigan governor. Bill Pugliano | Getty Images

Michigan Gov. Gretchen Whitmer issued a "Stay Home, Stay Safe" executive order Monday that directs residents to remain at home as much as possible. The restrictions go into effect on March 24 at 12:01 am, and continues through April 13. "If we all stay at home, except for critical work and needs, we can mitigate the spread of COVID-19," Whitmer said in a tweet announcing the order. The order will also help prevent the state's health care system from being overwhelmed, allow time for the production of critical medical equipment like test kits and ventilators, and prevent deaths from the virus, according to a statement from the Michigan state government. Michigan has 1,035 confirmed cases of the virus, according to data compiled by the state.

Massachusetts

Governor Charlie Baker holds a press conference on the state's efforts in dealing with the coronavirus at the Massachusetts State House in Boston on March 17, 2020. Matthew J. Lee | Boston Globe | Getty Images