Nutritional diet and physical exercise are widely considered as the vital components to make a healthy life style. Physical inactivity is the modifiable risk factor to Alzheimer’s disease, type II diabetes, cardiovascular diseases and metabolic syndromes. Sports/performance nutritional supplements help the athletes to perform high-intensity exercises and trainings and these sports nutritional foods are the functional foods to provide health benefits to not only the athletes but also to make a healthy adult in their day-to-day activities. This can be achieved by minimizing the impact of the factors that cause fatigue and impair the performance of skilled tasks.

To achieve a maximum performance during exercise some of the biological factors like nitric oxide levels, erythropoietin, dopamine and antioxidants should increase in blood. Repeated exercise can lead to an increase in the production of endothelial nitric oxide which if maintained between the exercise sessions, will be an important fact in explaining the beneficial effects of physical fitness on cardiovascular health. Increase of nitric oxide, nitrite, RBC, dopamine content are very important in pre exercise. But during any activity or exercise, the oxidative stress to the tissues and muscles are the principle reasons of fatigue. So it is very important to control the oxidative stress to the tissues and reduce the inflammatory markers in the body.

Erythropoietin (EPO) is an essential hormone for red blood cell production and treatment with recombinant human EPO increases hemoglobin(Hb) concentration and thus improves the aerobic physical fitness significantly. Moreover, it provides a significant increase in perceived physical condition and physical strength. EPO significantly enhances exercise capacity in patients with chronic heart failure and one proposed mechanism of improvement in VO2 is increased oxygen delivery from increased hemoglobin concentration. The neurotransmitter dopamine has become one of the most frequently used drugs in the treatment of critically ill patients with low cardiac output states and/or acute oliguric renal failure During and after exercise, the lower plasma levels of norepinephrine and epinephrine indicate a marked rise in conjugated dopamine which suggests that norepinephrine and epinephrine metabolism is shifted towards conjugated dopamine by exercise training.

Dopamine normally associated with neuromodulatory actions, and may directly affect local cortical blood flow. Some of the natural products fulfill all these requirements listed above for intense trainings and are a better and more accepted option over the chemical supplements widely publicized in the world markets these days. Aurea Biolabs formulated a unique ingredient named Fitnox®, as a formulation for physical endurance. The formulation consists of the extracts from nature which has got a variety of actions. Fitnox® as a single formulation can be used for both Pre and Post exercise. Clinically tested.

A FORMULATION FOR IMPROVING PHYSICAL ENDURANCE IN ATHLETES AND A METHOD FOR PREPARING THE SAME. Pub. No.: WO/2018/033892 International Application No.: PCT/IB2017/055026

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