The ASUS Republic of Gamers Crosshair VI Extreme Extended ATX Motherboard supports AMD Ryzen, A-series, and Athlon processors compatible with AM4 sockets and X370 chipsets, so you can build an AMD desktop system. With an X370 chipset, the ROG Crosshair VI Extreme provides two PCIe 3.0 x16 and three PCIe 2.0 x1 slots along with one PCIe 2.0 x16 slot. When an AMD Ryzen processor is installed, the two PCIe 3.0 x16 slots are enabled. For memory support, the motherboard comes equipped with four DDR4 slots, eight SATA connectors, and two M.2 slots. There's also 802.11ac Wi-Fi and Bluetooth 4.2 modules for wireless connections.

The ROG Crosshair VI Extreme provides features that allow you to overclock the AMD processor by coming armed with water-cooling support, QLED, and 5-Way Optimization technology. For customization, AURA Sync technology and onboard LEDs are available.

The back of the motherboard has two USB 3.1, six USB 3.0, and four USB 2.0 ports. One of the USB 3.1 ports with 10 Gb/s speeds sports a USB Type-C interface for easy connections with your USB-C cable. Other notable connections include an Intel Gigabit Ethernet port and optical S/PDIF out as well as five audio jacks, powered by a SupremeFX S1220 chipset.