Nick Kaldas the NSW Deputy Commissioner makes a statement about the two shootings in Sydney last night.

PREMIER Barry O'Farrell has been advised that the family of the 13-year old girl-shot overnight are currently talking to police.

Earlier today, he had lashed out at the parents for not co-operating with police.

The girl was hit when three gunmen believed to be looking for her brother let off four shotgun blasts into the single-storey brick house on Sunnyholt Rd, Blacktown about 11pm.

Police revealed this morning she is the sister of the intended victim, who is believed to have links to the Brothers For Life bikie gang.

She is recovering in Westmead Children's Hospital.

He said the gunmen's actions had taken the recent string of Sydney shootings to a whole new level.

"As they left the home they decided to blast shotgun pellets into the building and those pellets injured a 13-year-old girl," he said.

"There are families of these criminal outlaws who know what's happened and who by their silence are putting other people at risk."

Police have not discounted Brothers for Life founder Bassam Hamzy somehow being involved in the shootings despite being locked up for life in Goulburn's super max prison.

Deputy police commander Nick Kaldas said it was "possible'' Hamzy's influence could extend beyond prison bars.

"He can still talk to people even in side jail,'' he said.

Police would not comment on whether Hamzy had been interviewed by police over the shooting.

Quakers Hill Inspector, David Lagets, said the worst fears of police had been realised with the shooting of an innocent girl.

"I think the public are over these public shootings; I think our greatest fears have now been reached with an innocent person, a 13-year-old girl, now becoming a victim of this type of senseless activity," he said.

Insp Lagets said the attack was targeted with the girl's father, mother and two brothers also at the house which was known to police.

"Three males approached the front door and knocked on it, which was answered by the father, asking for a resident of the home as it's been targeted," he said.

"A verbal altercation was held at the front door and as a result four shotgun shots were let off at the front door. The three males have then walked off.

"As a result a 13-year-old occupant inside the house was struck by pellets and suffered wounds to her back.

"The mother and two brothers were also home. I believe that the person they asked for may have been home and the residence is known to police."

Distraught family members had to be calmed down by officers before they went to Westmead Children's Hospital.

The father spoke to detectives outside the house before he was taken to Quakers Hill Police Station to be interviewed.

"I was in my room and I heard people shouting and yelling," neighbour Prianka Naidoo said. "Then right after that there were four shots."

"It was really loud...at first I thought it was fireworks but then I realised it wasn't.

"Then I heard a woman screaming. She was screaming and another person was yelling. It was horrible."

Ms Naidoo, who only moved to the area recently, said the family who lived in the home seemed nice.

"They would always drive past and smile or wave at me," she said. "They don't look like they would have any enemies."

"I wanted to run out and see if they were ok but I was too scared."

A member of Anytime Fitness directly across the road from where the attack happened described chaotic scenes unfolding when he arrived at the gym.

"I was driving down and thought 'what is going on' as there were police, ambulances, dog squad and commotion all over the street," he said.

"Then I watched from the car park and there was screaming and police dragged out a guy who was pretty vocal, protesting and carrying on (police later confirmed the man was a family member not under arrest).

"There's been so many shootings, I live not far away and it's just creeping closer and closer."

Another man at Anytime Fitness said a man aged 19 or 20 who lives at the house was a member of the gym.

Police with torches carried out a line search out the front and to the sides of the house looking for evidence.

Forensic officers arrived and laid down evidence markers where the shotgun cartridges had fallen on the driveway before they were placed in plastic containers.

The driveway was examined with torches and the inside of the house was photographed before items were removed in brown paper evidence bags.

It is the latest incident of gun crime to rock Sydney in just over a week with people, cars and houses shot up across the city.

A woman's car was fired upon in a roadrage attack on Iris St, Riverwood about 10:30pm last night.

On Sunday night 27-year-old Brothers for Life gang member Michael Odisho was shot in the thighs and arms at his Winston Hills home about 11:15pm.

On the same night shots were fired into a three-storey townhouse on Blaxell St, Granville.

Yesterday morning shots were also fired at a house on McGuirk Way, Rouse Hill about 4am.

Last week Brothers for Life gang member Mahmoud Hamzy, 25, was shot dead by three gunmen inside the garage of his home at Revesby Heights about midnight.

Later in the week Raymond Pasnin, 27, was shot five times in the back and killed as he walked towards his car - parked in the driveway of his mother's Pendle Hill home - just after midnight