UPDATE: A cyclist has died in hospital after riding into the back of a Transperth bus in Melville.

According to police, the 57-year-old man crashed into the bus which was stopped on Marmion Street around 4.40pm on Thursday.

Camera Icon Police at the crash scene. Credit: 7 News

The Transperth bus was in the process of picking up and dropping off passengers when the male cyclist crashed into the back of it.

An off-duty nurse, who was at the neighbouring shops, rushed to provide first aid until paramedics arrived.

“The man sustained serious head injuries and was treated by paramedics at the scene,” a police spokesperson said.

He was rushed to Fiona Stanley Hospital but sadly died a short time later.

There are reports the injured cyclist, who was riding in a cycle lane at the time, was not wearing a helmet.

Camera Icon Major Crash investigators will arrive at the scene. Credit: 7 News

Major Crash officers are now investigating the crash and have put out a call for any witnesses to come forward.

Anyone with information is asked to call Crime Stoppers on 1800 333 000 or report it online at www.crimestopperswa.com.au