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ISLAMABAD — Demonstrators clashed with police in the Pakistani city of Peshawar on Friday as anger over insults to the Prophet Muhammad boiled over despite calls from political and religious leaders across the Muslim world for peaceful protest.

Western diplomatic missions throughout the Muslim world tightened security, with some closing down on expectation of big protests after Friday prayers.

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An anti-Islam film made in America has enraged Muslims and led to days of protests across the Muslim world while cartoons mocking the Prophet Muhammad published in a French magazine on Wednesday were expected to compound the anger.

Egypt’s highest Islamic legal official said on Thursday Muslims should follow his example of enduring insults without retaliating.

But the call looked unlikely to calm the outrage.

“An attack upon the Holy Prophet is an attack on the whole 1.5 billion Muslims. Therefore, this is something unacceptable,” Pakistani Prime Minister Raja Pervez Ashraf said in a speech to politicians, religious leaders and others.