Biggest threat on offense: Whether it’s because of the offensive line or a regression in his decision-making, Newton hasn’t looked like he did last year. Last season’s league MVP has completed a career-low 53.5 percent of his passes with 15 touchdowns and nine interceptions. Newton is still a dual-threat quarterback who can carry a team with his play, but the Panthers are 19th in total yards (340.3) and 13th in points per game (23.9).

Biggest threat on defense: Carolina rescinded the franchise tag on Redskins cornerback Josh Norman, but didn’t have anyone of his caliber to replace him. Despite a talented front seven, the Panthers have the third-worst pass defense in the league, allowing 272.4 yards per game. Still, Carolina is tough to run against — it’s fifth in the league, allowing 90.2 yards per game. Defensive tackles Star Lotulelei and Kawann Short are good interior linemen that will make it difficult for Washington to find any running lanes.

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Key injuries: The Panthers have been decimated by injuries. Four of their 11 players on injured reserve are offensive linemen, including center Ryan Kalil and tackle Michael Oher. Linebacker Luke Kuechly, who is the most important player on Carolina’s defense, has missed the past three games because of a concussion. Defensive end Charles Johnson (hamstring) did not play against San Diego and hasn’t practiced all week.