The scene of hit-run crash in Pakenham in which seven children and an adult were injured. Credit:Nine News

A driver has fled the scene after hitting seven children and seriously injuring a woman as they crossed a road in Melbourne's south-east on Friday afternoon.

It is believed a ute struck the woman and children as they crossed the intersection of Cardinia Road and Princes Highway in Pakenham just after 3.30pm.

The driver left his vehicle and ran away, police said.

A woman aged in her 30s suffered chest, back and shoulder injuries and was taken to The Alfred hospital in a serious condition, an Ambulance Victoria spokeswoman said.