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Global Human Microbiome Market – Rich Product Pipeline

Human microbiome play a major role in modern healthcare, as it allows easy digestion of food, regulation of immune system, and production of vitamins such as Vitamin K, Vitamin B, and Vitamin B12, which is essential for blood coagulation.

The global human microbiome market size was valued at US$ 46,913.4 million in 2017, and is expected to exhibit a CAGR of 17.5% over the forecast period (2018 – 2026).

Figure 1. Global Human Microbiome Market Value (US$ Mn), by Region, 2017

Source: Coherent Market Insights Analysis (2019)

Increasing prevalence of gastrointestinal disorder and cancer is expected to propel growth of the human microbiome market

Human microbiome boosts immunity, nutrition, and other uses. High incidence of C. difficile infection is expected to propel demand for antibiotics, prebiotics, and probiotics, which in turn is expected to drive the market growth. According to the Centers for Disease Control and Prevention in 2015, Clostridium difficile infection (CDI) is one of the most common healthcare-associated infections in the U.S., affecting over 500,000 people and causing about 29,000 deaths each year. According to a study published in the Clinical Infectious Disease Journal in 2015, about 25% to 33% of antibiotic-associated diarrhea and 90% of pseudomembranous enteritis are caused by CDI.

Similarly, according to International Agency for Research on Cancer September 2018 estimates, around 9.6 million death and 18.1 million new cases of cancer will be diagnosed in 2018.

Furthermore, introduction of probiotic may induce change in intestinal microbiota and can stabilize microbial communities, which may prevent gut inflammation, propelling growth of the human microbiome market during the forecast period. For instance, in February 2018, Dannon expanded its Activia range with the introduction of a range of low-fat yogurt drinks, Activia Dailies, in the U.S. Activia Dailies contain live and active probiotics.

Microbiome based diagnostic and therapeutic is relatively new concept which creates concern about its safety profile. Moreover, there is concern about true efficacy of microbiome-based platform. The establishment of link between dysbiosis of microbiome and disease is critical to establish clinical potential. For a microbiome-based diagnostic, establishing clinical evidence of the link between biomarkers and disease (cancer biomarkers) would be significant. This scenario presents unique set of a challenge for designing clinical trials as the lack of uniformity in microbiome in target patient pool may affect clinical trial outcomes and reproducibility.

Figure 2. Global Human Microbiome Market Share (%), by Product, 2018 and 2026

Source: Coherent Market Insights Analysis (2019)

Increasing prevalence of obesity in Asia Pacific is expected to boost the market growth

Asia Pacific holds dominant position in the global human microbiome market, owing to high prevalence of obesity shows alterations in gastrointestinal microbiota. According to Asian Development Bank Institute (ADBInstitute), June 2017 estimates around 1 billion people in Asia and the Pacific were obese and around 40.9% of adults in the region were overweight in 2013, compared with 34.6% in 1990. Increasing focus on human microbiome therapy in treatment of cancer in the region is also expected to boost the market growth. According to Asian Pacific Journal of Cancer Prevention, February 2004, in year 2000, around 3 million new cancer cases, and around 2 million cancer deaths, and around 5.4 million people living with cancer in Asia Pacific region.

Moreover, increase in need of early detection and diagnostics of cancer is expected to boost demand for human microbiome market. For instance, in August 2014, National Center for Biotechnology Information (NCBI), stated that Colorectal Cancer (CRC) is third most commonly diagnosed malignancy globally which accounts for around half million deaths annually. The abnormality in gut microbiome in CRC, if diagnosed early can exceed survival rate around 90%.

Key Players

Major players operating in the global human microbiome market include, Enterome Bioscience, Yakult Honsha Co., Ltd., DuPont, Metabiomics Corporation, ViThera Pharmaceuticals, Second Genome Inc., AOBiome LLC, Seres Therapeutics, uBiome, Inc., Rebiotix, Inc., Synthetic Biologics, Inc., MicroBiome Therapeutics LLC, Vedanta BioSciences, Osel, Inc., and Merck & Co., Inc.