Last month, artists Michael Di Liberto and Sunia Boneham moved into a two-story, three-bedroom house in Cleveland's Collinwood neighborhood, where about 220 homes out of 5,000 sit vacant and boarded up. They lined their walls with Ms. Boneham's large, neon-hued canvases, turned a spare bedroom into a graphic-design studio and made the attic a rehearsal space for their band, Arte Povera.

The couple used to live in New York, but they were drawn to Cleveland by cheap rent and the creative possibilities of a city in transition....