Serving Liberal senator Jane Hume has ruled out a switch to the lower house, declaring she will not seek preselection for the seat of Higgins following Kelly O'Dwyer's resignation.

Senator Hume - who lives in the federal seat and thought "long and hard" over the weekend about running - said the vacancy was an opportunity to bring "fresh talent" into the Liberal team.

Liberal senator Jane Hume lives in Higgins but ruled herself out of a tilt at the seat on Monday morning. Credit:Alex Ellinghausen

"I won't be contesting this preselection," she told ABC Radio National on Monday morning.

"Of course I thought about it over the weekend. I just love my roles in the Senate ... I realise the party has given me an extraordinary privilege by endorsing me for the next six years and I am very reluctant to leave the good work that I am doing there.