Among other things, he was accused of demanding that women masturbate him or massage him naked. A manicurist said that when she went to his office for an appointment in 2005, he pressured her to disrobe, lie on his massage table and have sex. The woman told co-workers about the episode at the time and filed a human resources report. Ultimately, Mr. Wynn paid her a $7.5 million settlement, according to The Journal.

Mr. Wynn has denied all the allegations, calling them “preposterous.”

Within a day of the article’s publication, Mr. Wynn, a major Republican donor, stepped down as finance chairman of the Republican National Committee. A few days later, the University of Pennsylvania revoked his honorary degree and removed his name from a campus plaza and scholarship. And the Massachusetts Gaming Commission promised an investigation, as Wynn Resorts is building a multibillion-dollar casino outside Boston.

After Mr. Wynn announced his resignation on Tuesday, the commission said it would “need to assess the overall impact and implications of this significant development.”

Mr. Wynn also stepped down as chairman of Wynn Macau, the arm of the company that focuses on Macau, the Chinese gambling enclave. Shares of Wynn Macau, which are traded in Hong Kong, had been halted pending the release of the announcement, but the company said it would seek to resume trading on Thursday. Wynn Resorts’ stock price had already tumbled in response to the misconduct allegations, from $200.60 on Jan. 25 to $163.22 on Tuesday.

In a statement, the company’s board said it had accepted Mr. Wynn’s resignation “reluctantly.”

“Steve Wynn is an industry giant,” Boone Wayson, nonexecutive director of the board, said in the statement. “He is a philanthropist and a beloved leader and visionary. He played the pivotal role in transforming Las Vegas into the entertainment destination it is today.”