Both applied to medical school at the University of Pennsylvania in Philadelphia, where they were accepted.

But before medical school began in 2015, Ms. Ryles and Mr. Lee made yet another international voyage, a sentimental trip back to China and Japan, where they revisited the Tameike-Sannō subway station in Tokyo to recreate their first kiss.

The next year, Mr. Lee proposed to Ms. Ryles in John F. Collins Park across from where they now live in Philadelphia in front of close friends and family. Mr. Lee’s parents and his younger brother, Jamie, as well as Ms. Ryles’s sister and brother-in-law, Elizabeth and Scott Downie, were all there to witness the moment. Afterward, everyone sat around a photo album that Ms. Ryles had been putting together since the day she met Mr. Lee, flipping through pages filled with pictures of their days in middle school, high school and college, and many other images from across a decade filled with more than 100,000 miles worth of sacrifice, commitment and dedication.

“It’s like no other fairy tale I have ever heard of,” Mr. Lee’s father, Yu-Ching Lee, said.

In May, Ms. Ryles will graduate from medical school and begin applying for obstetrician/gynecological residency programs, while Mr. Lee completes his Ph.D. in genomics and computational biology at the University of Pennsylvania.

“Every day when I see Hannah’s beautiful face,” Mr. Lee said, “I’m reminded that life is an exciting, happy, sad, inspiring, scary, wonderful, beautiful adventure.”

Their adventure continued on Feb. 2 in Philadelphia, where Ms. Ryles and Mr. Lee were married in a self-uniting ceremony at Union Trust, an events space where the reception was also held.