“Old lady house,” is the way Trey and Jenny Laird describe their four-story Upper East Side townhome, but the contemporary art inside — by the likes of Cindy Sherman, Louise Lawler, Michaël Borremans, Jenny Holzer and Tracey Emin — does not seem outdated in the least.

The Lairds, married for 22 years, divide their collection of about 300 works evenly among their three homes; the others are in the Hamptons and in Marfa, Tex. Both the Lairds are natives of the Lone Star State, and have occasionally bought art by Texans, including the sculptor Tony Feher.

“The houses all have a little bit of a different personality,” said Mr. Laird, 54, who founded the creative and branding agency Laird + Partners. “But at the same time, it’s always our aesthetic.”