POLICE are looking at alcohol and speed as possible causes of the horrific multi-vehicle crash that killed two men at Rhodes this morning.

Investigators have labelled the fatal crash as “absolutely devastating” as they look to inform the families of the deceased men.

media_camera Emergency services removing a body from a car at the scene of the fatal Rhodes car crash. Picture: Braden Fastier.

Detective Inspector Adam Powderly said no stone would be left unturned in the efforts to determine the cause of the crash.

“The scene is spread over a few hundred metres, it’s quite horrific,” Det Insp Powderly said.

“The investigation is in its infancy but police will be looking at a number of factors including alcohol and speed.”

media_camera Police and emergency services working to remove a body from the wreckage of the crash. Picture: Braden Fastier.

media_camera Detective Inspector Adam Powderly has said alcohol and speed could be factors in the crash. Picture: Braden Fastier.

The crash occurred at the Concord Road and Mary Street intersection at Rhodes about 10.45am and involved up to six cars and a truck.

The male drivers of two cars, a black Mercedes-Benz and another sedan, were killed in the collision.

In addition to the dead men, two four-year-old girls and their fathers were hospitalised, with one of the fathers trapped in the wreckage for some time before he was freed by emergency services.

The injured were taken to Westmead and Ryde hospitals for treatment.

media_camera The Mercedes-Benz involved in the crash has been completely written off. Picture: Adam Ward.

media_camera The smash caused significant damage to the semi-trailer involved. Picture: Adam Ward.

Canadian student Jonathan Wijayakumar was driving back from the airport with his cousin and uncle when he was nearly involved in the smash.

He described the moment his family were almost hit by the Mercedes-Benz that came tumbling through the air.

“We were driving along like normal, there was a bit of traffic and all of a sudden this car came tumbling through the air towards us,” he said.

“It really was coming straight for us, it was only a few feet from us, then it spun away and landed on the car next to ours.”

“I don’t think we could have been any closer,” he said.

media_camera Police from the Metropolitan Investigation Unit have been at the scene since the morning. Picture: Braden Fastier.

media_camera The fatal crash at Rhodes involved six vehicles including a semi-trailer. Picture: Adam Ward.

Office worker Peter Yuen was one of the first on the scene.

He said he and a few colleagues ran down to help and found debris and smoke everywhere.

“We heard it and just rushed down,” he said.

“We just checked their pulses. The guys who were crushed, we couldn’t do anything for them until the Fire Brigade came.”

The Metropolitan Investigation Unit have launched inquiries into the accident

Concord Road is closed at the scene with the exception of one southbound lane.

A local Mary St resident told the Inner West Courier that she “heard a loud bang possibly semi hitting the cars in opposite direction.”

“I heard a massive bang, by the sounds of it the semi colliding with two cars,” she said.

media_camera Police are speaking to witnesses at the scene of the crash. Picture: Adam Ward.

media_camera Cars have been completely destroyed as a result of the crash. Picture: Adam Ward.

Northbound motorists on Homebush Bay Drive are being diverted to head southbound on Concord Road, while northbound motorists on Concord Rd are being diverted to head southbound on Homebush Bay Drive.

Motorists can use Silverwater Rd and Victoria Rd as an alternative route.

For people travelling by bus, routes 458, 459 and M41 in Rhodes are diverting away from Concord Rd at Mary St.

RHODES: Concord Rd at Mary St is closed n/b & 2 of 3 s/b lanes closed due to serious car & truck accident. Avoid area or expect sig. delays. — Live Traffic Sydney (@LiveTrafficSyd) January 5, 2015