See where you are coming from Jaiho with your first combo, and if I had to, and I mean "had to" use an SSRI again, then Sertraline plus a TCA would be where I would go. I just don't believe the DRI effect of Sertraline is in the least bit noticeable, from my experience at 50mg right up to 250mg. I much prefer the dopamine action from 5HT antagonism.



So I take Nardil 75mg, Trazodone 150mg and Amitriptyline 20mg and its extremely effective. I`m so self-confident I`ll take you all on !! :-)



Nardil speaks for itself. The trazodone has some antagonist action on 5ht2a and @ 150mg, some effect on 5ht2c, and hopefully being on just 150mg will keep me away from any SRI action. It also helps me reduce the number of Nardil early awekenings, which I do love, but after a few days they can catch up on you and it helps firm things up if you know what I mean :-) (Not that I need it haha ).



The low dose of amitriptyline somehow just rounds things off nicely, increased energy, mood and quite hedonistic for some reason. As per Nortriptyline (its metabolite) I know it has some 5ht receptor stuff but not sure what dose that kicks in at.