Talk show host Oprah Winfrey would easily beat President Trump in a 2020 match-up, a new poll indicates, but Democratic and liberal household names Joe Biden and Bernie Sanders would best the Republican by more.

The new survey, conducted by SSRS and commissioned by CNN, found that Winfrey would best Trump among registered voters by nine points, with the talk show queen receiving 51 per cent and the sitting president getting 42 per cent.

Former Vice President Joe Biden would take 57 per cent of registered voters surveyed, to Trump's 40 per cent – winning by the biggest margin of the three – while former Democratic candidate, Sen. Bernie Sanders of Vermont, would beat Trump 55 per cent to 42 per cent.

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President Trump's battle for re-election is looking like an uphill climb, with new numbers from CNN suggesting he could be easily beat by former Vice President Joe Biden, Sen. Bernie Sanders and Oprah Winfrey, whose Golden Globe speech prompted calls for her to run

While all three Democrats polled higher than President Trump in a 2020 match-up, Vice President Joe Biden (right) and Sen. Bernie Sanders (left) performed better than Oprah Winfrey (center), who has no political experience

Among registered voters, new polling indicates that former Vice President Joe Biden would have the biggest edge against President Trump in a potential 2020 match-up, but the Republican would also be defeated by Sen. Bernie Sanders and Oprah Winfrey

Winfrey, who has no political experience, earns the biggest chunk of undecided registered voters when she's matched up against Trump, with 7 per cent saying they don't know who they would vote for or would choose someone else.

President Trump trounced 2016 Democratic nominee Hillary Clinton with the white vote, 57 per cent to 37 per cent, according to CNN's exit polls.

That margin evaporates in the newest poll, with Biden getting the most support among white registered voters, beating Trump 50 per cent to 48 per cent.

Sanders and Winfrey perform better too, with Sander attracting 48 per cent to Trump's 49 per cent, and Winfrey receiving 45 per cent to Trump's 50 per cent of white registered voters.

The poll also shows white women voting for the Democratic candidates instead of the Republican, like they did in 2016.

Biden wins white women by 23 points, while Sanders has a 17-point edge and Winfrey wins the group by 14 points.

When women of color are added into the equation the Democrats have an even better showing, with Winfrey holding a 29-point lead over Trump, Sanders receiving a 30 point lead over the president and Biden, again doing the best, with a 36-point spread.

Former Vice President Biden has said he's purposely not making a decision about 2020 yet, while Sanders – an independent who ran for the nomination the last time around – hasn't laid out his plans yet.

Winfrey has said in the past she has no plans to run for office, but was intrigued by calls for her to run in the aftermath of an impassioned Golden Globes speech.

Political polling is something that has always riled up President Trump, as he relished good numbers on the campaign trail through 2016, while refusing to believe he actually has historically low approval numbers this year and last.

His current Real Clear Politics approval average stands at 39.6 per cent.

Vanity Fair reported Monday that Trump was 'frustrated that he's not getting more credit for positive news like the booming stock market and low employment numbers,' the president told a friend.

The president also insisted, the magazine said, that his real approval rating was 'in the high 50s.'