The Senate is poised to vote on Betsy DeVos’s confirmation as secretary of Education at noon Tuesday, with Vice President Pence possibly casting a tie-breaking vote backing President Trump’s controversial Cabinet pick.

Republicans have only 50 votes behind DeVos with the defections of GOP Sens. Susan Collins Susan Margaret CollinsThe Hill's Campaign Report: Biden asks if public can trust vaccine from Trump ahead of Election Day | Oklahoma health officials raised red flags before Trump rally Gideon leads Collins by 12 points in Maine Senate race: poll Senate leaders quash talk of rank-and-file COVID-19 deal MORE (Maine) and Lisa Murkowski Lisa Ann MurkowskiGOP ramps up attacks on Democrats over talk of nixing filibuster OVERNIGHT ENERGY: House Democrats tee up vote on climate-focused energy bill next week | EPA reappoints controversial leader to air quality advisory committee | Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' House Democrats tee up vote on climate-focused energy bill next week MORE (Alaska), which could lead to a historic moment for Pence.

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He would be the first vice president to ever cast a decisive vote in a 50-50 tie over confirming a Cabinet nominee.

Pence would also be the first vice president to break a Senate tie since 2008, when then-Vice President Dick Cheney cast a vote on a tax adjustment plan.

No Democrats are backing DeVos, and no other Republicans are expected to break with her, despite a last-ditch effort by the minority party to put pressure on the GOP.

Republican Sens. Pat Toomey (Pa.), John Hoeven John Henry HoevenDavis: The Hall of Shame for GOP senators who remain silent on Donald Trump Bottom line Bipartisan senators seek funding for pork producers forced to euthanize livestock MORE (N.D.), Dean Heller Dean Arthur HellerOn The Trail: Democrats plan to hammer Trump on Social Security, Medicare Lobbying World Democrats spend big to put Senate in play MORE (Nev.) and Deb Fischer Debra (Deb) Strobel FischerHillicon Valley: Election officials prepare for new Russian interference battle | 'Markeyverse' of online fans helps take down a Kennedy | GOP senators unveil bill to update tech liability protections Google, Apple, eBay to meet virtually with lawmakers for tech group's annual fly-in Congress botched the CFPB's leadership — here's how to fix it MORE (Neb.) — each considered potential swing votes — have announced their support for DeVos.

Minority Leader Charles Schumer Chuck SchumerDemocrats scramble on COVID-19 relief amid division, Trump surprise Pelosi, Schumer 'encouraged' by Trump call for bigger coronavirus relief package Schumer, Sanders call for Senate panel to address election security MORE (D-N.Y.) on Monday pled with Republicans from the Senate floor, urging them not to put “party above country.”

“We need just one more vote, and we can get a lot better secretary of Education than the one who was nominated,” Schumer said.

Democrats have targeted eight Trump Cabinet picks, including DeVos, but Schumer argued that the Education pick is the “least qualified” of Trump’s nominees.

DeVos, a GOP mega-donor long active on education issues, has been the subject of fierce opposition from teachers unions and other liberal groups opposed to her support for charter schools and tuition vouchers that use public funds.

She has also come under fire from Democrats over reports that several lines and phrases in her committee-submitted questionnaire appeared to be lifted without attribution from other sources.

And DeVos endured a rocky confirmation hearing in which she at one point appeared to advocate for guns in school because of the possibility of a grizzly bear attack, at least in Wyoming.

Sen. Elizabeth Warren Elizabeth WarrenNo new taxes for the ultra rich — fix bad tax policy instead Democrats back away from quick reversal of Trump tax cuts It's time for newspapers to stop endorsing presidential candidates MORE (D-Mass.) joined the Democratic floor protest, arguing “it is difficult to imagine a worse choice” to head up the department.

“The Republicans have made it clear no matter her experience, no matter her radical views ... they will ram this nomination down the throats of the American people sideways,” Warren, a possible presidential candidate in 2020, said during a nearly hourlong speech.

Warren said on Monday that DeVos’s performance during her confirmation hearing — which was panned by pundits in both parties — was “shocking.”

“I assume that the rush to complete this nomination has something to do with the fact that Republicans’ phones have been ringing off the hook,” she added.

Liberals have sought to jam Republican phone lines with protests over DeVos’s nomination. Senators in both parties say they have received thousands, if not tens of thousands, of calls, emails and letters urging them to oppose the nomination.

Progressive groups, including the American Federation of Teachers and the Leadership Conference on Civil and Human Rights, paired up with teachers and students to rally against DeVos’s nomination outside of the Capitol on Monday evening.

Republicans on Monday said they were confident DeVos would win a victory on Tuesday.

“I’m confident we’ll get Ms. DeVos confirmed soon,” said Sen. John Cornyn John CornynSenate Republicans signal openness to working with Biden Hillicon Valley: DOJ indicts Chinese, Malaysian hackers accused of targeting over 100 organizations | GOP senators raise concerns over Oracle-TikTok deal | QAnon awareness jumps in new poll Republican Senators raise concerns over Oracle-TikTok deal MORE (Texas), the No. 2 Senate Republican. “Then, thanks to former Democratic leader Harry Reid Harry Mason ReidSenate Republicans signal openness to working with Biden Mellman: The likely voter sham Bottom line MORE ... every single one of President Trump’s Cabinet nominees will be confirmed. We can take that to the bank.”

In a 2013 decision, Democrats, led by the Nevada senator, decided to get rid of the higher 60-vote procedural threshold for lower-court nominees and Cabinet picks.

The Democrats’ decision made it easier to confirm some of Obama’s nominees in 2013 and 2014, but under the old rules, DeVos’s confirmation almost certainly would have been blocked.

Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellSenate Republicans signal openness to working with Biden Hillicon Valley: DOJ indicts Chinese, Malaysian hackers accused of targeting over 100 organizations | GOP senators raise concerns over Oracle-TikTok deal | QAnon awareness jumps in new poll The Hill's Campaign Report: Biden asks if public can trust vaccine from Trump ahead of Election Day | Oklahoma health officials raised red flags before Trump rally MORE (R-Ky.) blasted Democrats for slow-walking Trump’s nominees. Trump has gotten seven of his picks confirmed — the same number President Obama got confirmed on the first day of his administration in 2009.

“Enough is enough,” McConnell said on Monday. “It’s far past time to put the election behind us and put this President’s Cabinet into place — just as previous Senates have done for previous newly elected Presidents of both parties.”

Republicans on Monday noted that the pace of Trump’s nominees is the slowest since George Washington, citing data from the Senate Historical Office.

The growing GOP frustration over the treatment of Trump’s nominees comes after Republicans changed the rules on some committees to leapfrog Democratic boycotts and approve Trump’s nominees without a Democrat present.

Cornyn — who has defended the GOP maneuvers — accused Democrats of playing “petty politics.”

“This type of behavior is pretty juvenile if you ask me, and it can’t actually accomplish anything,” he said. “They don’t have any particular goal in mind because at the end of the day, the president will get the Cabinet that he has nominated and deserves.”