Two teenagers from the Taber area were killed Thursday when their pickup truck collided with a semi on a rural road, according to Alberta RCMP.

Coaldale RCMP responded to the collision at the intersection of Township Road 100 and Range Road 192 around 3:35 p.m.

"The 17-year-old driver and 14-year-old passenger were both crushed within the cab of the truck and pronounced deceased at the scene," RCMP said in a release.

The 25-year-old driver of the semi suffered less serious injuries and was taken to hospital in Lethbridge for treatment.

RCMP said the collision occurred at the intersection of Township Road 100 and Range Road 192. (CBC)

The investigation found the semi was travelling westbound on the township road and the southbound F350 "slammed broadside" into the trailer.

"This was a high-speed impact that caused the semi and trailer to be flipped at least once," police said.

The investigation is ongoing but RCMP said there are yield signs posted on both the north and south sides of the intersection between the two gravel roads.

Conditions were sunny and clear at the time of the crash.