LAS VEGAS — Injuries to quarterbacks are a part of the game and inherent risks that bettors take. A totally unexpected retirement by an elite quarterback is not part of the playbook.

The breaking news of Andrew Luck’s retirement Saturday night forced bookmakers to audible and immediately adjust all odds on the Indianapolis Colts, who no longer were Super Bowl contenders when the books opened for business Sunday morning.

As VSiN analyst and former NFL executive Michael Lombardi said, “Who retires at 30 years old probably in the prime of his career?”

Obviously, Luck is wired a little differently. He spoke of mental and physical fatigue from ankle and calf injuries that lingered all summer and triggered his decision to quit two weeks before the Colts’ season opener. Luck, who will turn 30 on Sept. 12, just had the best year of his career after overcoming a right shoulder injury.

William Hill sportsbook director Nick Bogdanovich said he does not consider this doomsday for the Colts, but he moved their Super Bowl odds from 20/1 to 50/1 and adjusted their win total from 10 (Under -130) to 7½ (Under -120).

The drop-off from Luck to Jacoby Brissett, who has been considered one of the better No. 2 quarterbacks in the league, is at least four points. The Colts are now 7-point road underdogs in their Sept. 8 opener against the Chargers, with some books going to 7½. The line was Chargers -3 before Luck’s retirement.

“I do think the Colts can still be competitive,” Bogdanovich said. “Brissett knows it’s his team now, so maybe he can settle in and play well. Maybe the stars align.”

Bogdanovich’s view is on the optimistic side. William Hill dropped the Colts’ win total from 10 to 7¹/₂. FanDuel sportsbook made the most dramatic adjustment, going from 9½ to 6½.

At the Westgate SuperBook, the Colts’ odds to win the AFC moved from 6/1 to 30/1, and the prop price on Indianapolis to make the playoffs was adjusted from “Yes” -200 to “No” -300. Odds to win the AFC South also changed, with the Colts going from 5/7 favorites to 4/1.

“It was a shocker for sure,” said Westgate SuperBook vice president Jay Kornegay, who made a quick change to the Colts’ playoff odds before any bettors could take a shot at an advantageous number.

At William Hill, Luck was the second choice on the MVP futures board at 8/1 odds and drew only six tickets for a total of $140. But it was a different story at the SuperBook, where Luck ranked third in the MVP ticket count behind Browns QB Baker Mayfield and Bears QB Mitchell Trubisky. The Westgate had written 44 tickets on Luck at 10/1 odds, and the largest wager was for $1,000.

The MVP odds sheet states: “All bets are action.” However, Kornegay said he met with his staff Sunday and the decision was made to refund Luck bets.

“I just felt like it was the right thing to do,” Kornegay said. “It’s retirement. Obviously it’s a totally different situation if the player was injured. If there was a time to refund something, this was it. It was not like we were looking for kudos. People had no shot on this.”

Luck passed for 39 touchdowns last season — second in the league behind the Chiefs’ Patrick Mahomes — as Indianapolis finished 10-6. In the other three seasons Luck did not deal with a right shoulder injury, the Colts went 11-5 each time. In his seven-year career, Luck posted a 53-33 record straight up. He was 49-34 against the spread, winning +12.52 units with a 14.6 percent return on investment, according to BetLabsSports.com. This means a $100 spread bettor made a total of $1,252 riding Luck in every start throughout his career.

The health of a star quarterback is imperative to any futures wager, and Luck serves as the latest lesson. The Colts’ future is nowhere near as bright with Brissett, who was acquired in a 2017 trade with New England. He started 15 games for Indianapolis that season and went 4-11.

“The Colts have a good team and they had Super Bowl aspirations,” Lombardi said. “It’s probably better for the Colts that Luck made the decision. It’s painful to say. But that’s life and we just move on.”