Metformin was discovered in 1922. R

It is one of the few miracle drugs that has ever been created.

Many of the benefits metformin seems to have is through increasing production of butyrate and HDAC inhibition, in butyrate deprived diabetes patients.

Metformin is a biguanide derived from the plant Galega officinalis. R

G. officinalis is rich in guanidine, which has helped create other biguanides. R

Other biguanides have been used for diabetes, such as phenformin and buformin, but they are commonly associated with lactic acidosis. R