A motorcyclist has died after failing to stop for police and crashing in the southern Perth suburb of Bibra Lake.

The crash happened near the intersection of North Lake and Phoenix Road just before midnight on Wednesday.

Police said they tried to stop the motorcyclist - a man aged in his 30s - at the intersection but he accelerated away and crashed shortly afterwards.

Officers administered first aid to the man until paramedics arrived.

He was taken to Fiona Stanley Hospital but later died.

Police said he is yet to be formally identified.

Major Crash officers remain at the scene and some roads are closed in the area.