The Senate voted Thursday to end debate on fast-track trade legislation, handing a significant victory to President Obama and moving the bill a step closer to passage.

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Senators voted 62-38 on the bill, which will allow the president to send a sweeping Asia-Pacific trade deal to Congress for an up-or-down vote, and prevent the deal from being amended by Congress.

Sens. Patty Murray (Wash.), Maria Cantwell (Wash.) and Jeanne Shaheen (N.H.) were among the final Democratic yes votes.

They appeared to vote after Cantwell secured an agreement from Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellMomentum growing among Republicans for Supreme Court vote before Election Day Trump expects to nominate woman to replace Ginsburg next week Video of Lindsey Graham arguing against nominating a Supreme Court justice in an election year goes viral MORE (R-Ky.) to allow a vote in June on renewing the Export-Import Bank's charter.

The bank, which has come under criticism from conservative Republicans, helps finance U.S. investments meant to increase trade, and has been supported in the past by Boeing.

The very final vote was cast by Sen. Rob Portman (R-Ohio), a former U.S. trade representative for the Bush administration who is in a tough reelection cycle. He voted yes.

Thirteen Democrats in total voted to end debate on a measure that badly divided Obama from his party. Senate Minority Leader Harry Reid (D-Nev.) and Sen. Elizabeth Warren (D-Mass.) were among his fiercest opponents.

Senate Republicans say votes on amendments and final passage of fast-track are unlikely before Friday. They are hoping to wrap up the trade package Friday afternoon.

“I don’t think so, not without a miracle,” Senate Finance Committee Chairman Orrin Hatch (R-Utah) said, downplaying the prospect of passing it Thursday.

But Sen. Sherrod Brown Sherrod Campbell BrownBipartisan praise pours in after Ginsburg's death Emboldened Democrats haggle over 2021 agenda Hillicon Valley: Russia 'amplifying' concerns around mail-in voting to undermine election | Facebook and Twitter take steps to limit Trump remarks on voting | Facebook to block political ads ahead of election MORE (D-Ohio), who is leading the Democratic opposition, said a vote on final passage before Saturday strikes him as too hasty.

“I don’t think it’s that quick,” he said.

Hatch agreed the trade debate could stretch into Saturday.

If the measure is approved by the Senate, it will set up an even tougher fight for Obama in the House, where opposition to the bill is stronger from Democrats and many Republicans reflexively do not want to give him additional power.

The vote comes as GOP Senate leaders scramble to finish up work ahead of the weeklong Memorial Day recess.

In addition to the trade legislation, Senate Majority Leader Mitch McConnell (R-Ky.) wants to wrap up surveillance and highway bills before senators leave town. The fight over the NSA could force a rare weekend session.

Senators were unable to reach a deal on amendments prior to the vote.

The push for additional amendments was complicated Wednesday by presidential hopeful Sen. Rand Paul (R-Ky.), who took over the Senate floor for more than 10 hours to lambast the government's surveillance programs.

But, because the Senate was debating the trade legislation, the Kentucky Republican was actually blocking his Senate colleagues from coming forward and offering, debating, and, potentially, voting on amendments.

Democrats, however, placed the blame for the lack of amendment votes squarely on McConnell.

“After one full day of debate, the majority leader shut down debate,” Brown, a fierce fast-track critic, said ahead of the vote. “That's an open process?”

The Ohio Democrat suggested that senators should stay through the weeklong Memorial Day recess to have more amendment votes on the trade legislation.

“It doesn’t really matter about the time,” he said.

The other Democrats who voted to end debate were Sens. Tom Carper (Del.), Claire McCaskill (Mo.), Dianne Feinstein (Calif.), Heidi Heitkamp (N.D.), Chris Coons (Del.), Mark Warner (Va.), Michael Bennet (Colo.), Tim Kaine (Va.), Bill Nelson (Fla.) and Ron Wyden (Ore.), the ranking member of the Senate Finance Committee.

Five Republicans voted against ending debate: Sens. Susan Collins (Maine), Richard Shelby (Ala.), Jeff Sessions (Ala.), Mike Lee (Utah) and Paul.

Sessions, who has been critical about not getting a vote on his amendment, said just before the vote that he would oppose cloture, saying that the fast-track legislation meant Congress would "suspend several of its most basic powers for the next six years and to delegate those powers to the executive."

Alexander Bolton contributed to this story.

This story was updated at 3:25 p.m.