A 27-year-old woman has been charged with murder over the fatal stabbing of a man in Thomastown on Saturday night.

Police and paramedics were called to the unit in Main Street just after 10pm and found the 67-year-old male resident with life-threatening injuries.

Police at the scene of the murder in Thomastown in 2015. Credit:Simon O'Dwyer

The man was taken to the Royal Melbourne Hospital with critical injuries to his upper body. He died a short time later.

On Sunday, forensic investigators were examining the unit, one of eight ground-level homes near the corner of Mount View Road.