Hillary Clinton has another reason not to run for mayor of New York – longtime nemesis Rudy Giuliani is hinting that her reentry into the political arena would cause the resumption of investigations against her.

Giuliani got asked about Clinton's future prospects after Newsmax reported on aides and donors floating the failed presidential candidate as a potential candidate for his old job.

'Youv'e gotta be kidding,' Giuliani told 'Fox and Friends' on Tuesday.

'No – not again not that story again,' he added.

Then, playing out the scenario, Giuliani said: 'I don't' know – I guess all of the investigations get revived again,' laughing.

Hillary Clinton is expected at the State Department for the unveiling of an exhibition hall named after her ©JEWEL SAMAD (AFP/File)

President-elect Donald Trump said during the campaign that he would name a special prosecutor to investigate Clinton, and his crowds regularly chanted 'lock her up.'

After the election, Trump backed off, saying Clinton had 'suffered greatly,' and adding that prosecuting Clinton is 'just not something I feel very strongly about.'

Any run for the high profile mayoral job was already considered unlikely. The post is currently occupied by former Clinton aide Bill de Blasio, who took his time but ultimately campaigned for Clinton.

If Clinton runs for mayor of New York, ''I don't' know – I guess all of the investigations get revived again,' Rudy Giuliani said on 'Fox and Friends'

Speaking to Jake Tapper today on CNN's State of the Union, Neera Tanden, the head of the progressive Washington think tank, the Center for American Progress, said she thought Clinton would continue her work helping children and families.

'But I don't expect her to ever run for any elected office again,' said Tanden, asked to give her take on whether Clinton might entertain New York City Democrats asking their party's former nominee to enter the city's mayoral race.

'I think she's going to figure out ways to help kids and families,' Tanden said. 'That's been what she's been focused on her whole life, and a lot of issues that are affecting them, over the next couple of years.'

'But I don't expect her to ever run for any elected office again,' she added.

Tanden was reacting to a New York Times article speculating about whether Clinton would run for New York mayor against the incumbent Bill de Blasio, her former campaign chief.

'I don't expect her to run for this and I don't expect her to run for other office,' Tanden said, without giving more specifics about the 69-year-old former secretary of state's plans.

'I think her job is to -- what she's thinking about right now is how to help those kids and families as she has her whole life.'

However, Clinton hasn't completely withdrawn from the public life since her defeat on November 8.

She has taken part in two public events and fired off a few tweets.

She's expected at the State Department on Tuesday for the unveiling of an exhibition hall named after her.