The 49ers and Seahawks was always a marquee matchup in the early part of the decade. The series has been dominated by Seattle since Jim Harbaugh left after the 2014 season. The Seahawks have won seven of the eight matchups since 2015. The lone win for the 49ers came last season when the 49ers ended the Seahawks’ 10-game winning streak in the series.

Monday night will be the biggest game between these two since the infamous 2013 NFC Championship Game. Here are the three matchups that will decide this edition of the rivalry:

K’Waun Williams vs. Tyler Lockett

K’Waun Williams is the best slot cornerback in the league in terms of passer rating against according to Pro Football Focus. He’s held up well this season against some tough tests. Juju Smith-Schuster was held to 81 yards on three receptions, with 76 of those yards coming on a touchdown where he was guarded by Ahkello Witherspoon. Cooper Kupp was held to 17 yards on four receptions in the 49ers’ Week 6 win against the Rams.

While Williams stood out against the two notable slot receivers he’s faced this season, Lockett will be his toughest test. Of his 767 yards this season, 604 have come from the slot. Not only is he effective lining up there, but he’s also Russell Wilson’s favorite target. Last week against Tampa Bay was a prime example with Lockett notching 13 receptions on 18 targets for 152 yards and two touchdowns. DK Metcalf was the next-most targeted receiver with nine targets.

Lockett can do a little bit of everything and will see the ball a lot on Monday night. Williams can shut down a lot of the Seattle offense with a big game vs. Lockett.

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