A major spoiler alert has been revealed for "Jeopardy!" fans - and there's a surprising Chicago connection to it all.

It seems James Holzhauer isn't invincible after all.

The game show's 32-time champion finally lost in an episode that airs Monday, falling short of records for total winnings and longest reign but leaving little doubt he's the best to ever play television's most popular game.

In a video of the moment that circulated online, the professional sports gambler from Las Vegas is shown high-fiving the woman who beat him, Chicago librarian Emma Boettcher.

The streak made Holzhauer a household name and sent ratings soaring, at a time "Jeopardy!" needed a pick-me-up following host Alex Trebek's announcement that he had cancer.

Holzhauer nearly doubled the show's previous record for one-day winnings by earning $131,127 on his tenth game, and he leaves with the 16 highest one-day scores in the show's history.

He combined a savant-like knowledge of the world with a mastery of the buzzer, allowing him to beat opponents to the punch, and adding a gambler's cold-blooded instinct to make big bets. Often in the show's first round, he'd quickly pile up as much money as he could, and then bet it all if he landed on a Daily Double that allows him to choose how much money to risk.

"I really felt like I had been playing with house money, so I wasn't too upset to see my run end," Holzhauer said in an email interview. He said he ran into "a terrific opponent playing flawlessly."

Holzhauer also took to Twitter ahead of the broadcast alluding to the "Drake" curse that has taken social media by storm.

Copyright Associated Press / NBC Chicago