A group opposed to the GOP's efforts to repeal and replace ObamaCare is set to a launch a $1.5 million ad campaign on Monday urging five key Republican senators to vote against the chamber's expected healthcare bill.

The ad campaign by Community Catalyst Action Fund targets Sens. Susan Collins Susan Margaret CollinsThe Hill's Campaign Report: Trump faces backlash after not committing to peaceful transition of power Billionaire who donated to Trump in 2016 donates to Biden Credit union group to spend million on Senate, House races MORE (Maine), Jeff Flake Jeffrey (Jeff) Lane FlakeHow fast population growth made Arizona a swing state Jeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Republican former Michigan governor says he's voting for Biden MORE (Ariz.), Lisa Murkowski Lisa Ann MurkowskiOVERNIGHT ENERGY: House passes sweeping clean energy bill | Pebble Mine CEO resigns over secretly recorded comments about government officials | Corporations roll out climate goals amid growing pressure to deliver The Hill's Morning Report - Sponsored by Facebook - Trump previews SCOTUS nominee as 'totally brilliant' Abortion stirs GOP tensions in Supreme Court fight MORE (Alaska), Dean Heller Dean Arthur HellerOn The Trail: Democrats plan to hammer Trump on Social Security, Medicare Lobbying World Democrats spend big to put Senate in play MORE (Nev.) and Shelley Moore Capito Shelley Wellons Moore CapitoCongress must finish work on popular conservation bill before time runs out Second GOP senator to quarantine after exposure to coronavirus GOP senator to quarantine after coronavirus exposure MORE (W.Va.), all Republicans who voiced concerns over the Republican Senate bill.

In a television ad airing in each senator's state except for Arizona, a young boy is seen having an asthma attack, while his mother rushes for his inhaler.

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"When this happens, she isn't thinking about the healthcare bill in Congress," a narrator says. "She isn't thinking that it will force her to choose between filling his prescriptions or paying their mortgage. She isn't thinking that when her premiums go up, they'll lose their health insurance. And she shouldn't have to."

The narrator then urges each senator — depending on the state — to "consider what's right" for their constituents and vote against the healthcare measure.

In a radio ad, which is set to air in Alaska, Nevada, Arizona and West Virginia, a woman says that the Republican healthcare bill would cut healthcare and social services for senior citizens, leaving her unable to take care of her elderly parents.

"I'm raising my kids and working two jobs," the woman says. "Without these services, I couldn't manage caring for my parents too. Just one vote in Congress could break us."

Each state targeted in the ad, except for Maine, accepted the Affordable Care Act's Medicaid expansion.

Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellTrump 'no longer angry' at Romney because of Supreme Court stance On The Money: Anxious Democrats push for vote on COVID-19 aid | Pelosi, Mnuchin ready to restart talks | Weekly jobless claims increase | Senate treads close to shutdown deadline The Hill's Campaign Report: Trump faces backlash after not committing to peaceful transition of power MORE (R-Ky.) has said that he hopes to push the bill to a vote by the end of the month.

But Senate Democrats and some Republicans have complained that the legislation has largely been crafted behind closed doors, leaving lawmakers unaware of what they would be voting for.

The bill could only afford to lose the support of two Republicans in order to meet the 50 votes need to pass. Not a single Democrat has said they will support the measure.