2017 Nootropics Survey on /r/Nootropics

Caution: this presentation of survey results is based completely on aggregated subjective experience. This survey was conducted for research and educational purposes only. It is strongly advised not to make decisions based on this data set. Before deciding to use any of these substances, consult a qualified medical professional and, if you suffer from any mental health problems, a mental health professional. The reported doses are likely to be inaccurate and it is highly recommended not to decide on the dose of a nootropic based on these data!

Introduction

tl;dr: most substances seem to have no or only slight effects when rated subjectively. Most substances with substantial effects were already well-known for their effects, some of them are prescription drugs or pharmaceuticals.

Sample Description

Age. The mean participant age was 26.86 years (standard deviation = 9.68, range = 12–88).

Gender. From the total sample of 380 participants, 325 (91.07%) male and 29 (9.89%) female participants completed the survey. 19 did not answer and 7 chose the “other” option for gender. From those seven participants, three gave a valid response, while four answered “attack helicopter”. Those three participants were either non-binary, trans-male or trans woman. The male-to-female ratio can be considered rather extreme even for Reddit standards, which was roughly 70/30 in an analysis a couple of years ago and can be compared to extremely male-dominated subreddits like /r/baseball or /r/Libertarian.

Country of residence. The vast majority of participants were from English speaking countries. The table lists the top 10 most frequent responses. Other countries included Switzerland (5 participants), France (3), Italy (3), Netherlands (3), New Zealand (3), Portugal (3) and South Africa (3).

Country Frequency USA 185 Not answered 47 Canada 23 UK 22 Australia 14 Germany 8 Belgium 6 Russia 6 Spain 5

Personality Scores

A brief personality inventory, the Mini-IPIP, was administered. It measures the Big Five personality traits:

Extraversion: This trait includes characteristics such as excitability, sociability, talkativeness, assertiveness and high amounts of emotional expressiveness. High levels of this trait are associated with more friends, higher life satisfaction and lower rates of mental disorders.

Agreeableness: This personality dimension includes attributes such as trust, altruism, kindness, affection, and other prosocial behaviors. This dimension is a good predictor of job choice: agreeable people tend to choose professions that involve caring and nurturing behavior and low competition, like nurse, psychotherapist, teacher, charity worker or doctor (excluding surgeons). People low in agreeableness tend to like competition and choose professions that require less compassion, like CEO, lawyer, journalist, police officer or chef. Agreeableness also predicts political views, as agreeable people tend to be liberals or leftists, while disagreeable persons are conservative or right-wingers.

Conscientiousness: Common features of this dimension include high levels of thoughtfulness, with good impulse control and goal-directed behaviors. Those high in conscientiousness tend to be organized and mindful of details. This trait predicts academic and job success quite well.

Neuroticism: Individuals high in this trait tend to experience emotional instability, anxiety, moodiness, irritability, and sadness. High scores on this dimension are often, but not necessarily, associated with anxiety disorders and depression.

Openness: This trait features characteristics such as imagination and insight, and those high in this trait also tend to have a broad range of interests. This dimension is somewhat correlated with IQ.

The scores of this sample were compared to a larger sample of college students used to validate this personality questionnaire.

| Dimension | Mean | SD | Interpretation | |—|—|— |—| | Extraversion | 2.67 | .94 | Low | | Agreeableness | 3.46 | .87 | Low | | Conscientiousness | 2.99 | .81 | Low | | Neuroticism | 2.93 | .83 | High | | Openness | 4.03 | .73 | High | Means and standard deviations for the big five personality scales, interpretation (low or high) when compared to a reference sample. All differences are statistically significant with medium effect sizes

Nootropics: Use and Perceived EFfects

Participants were asked about their usage of 63 different nootropics. If a participant indicated that they tried a nootropic, they were asked about the perceived effects with this substance later.

Perceived Effects

All perceived effects were rated on seven-point scales. The following graphs summarize the results. Substances are listed on the y axis, ranging from the highest to lowest mean rating. The points indicate the mean rating for this substance. Lines indicate a 95% confidence interval (CI), thus expressing the uncertainty of the respective mean. Wider CIs indicate a greater variety of responses. The red line indicates the neutral response labeled “no effect“. As a rule of thumb, all mean ratings with confidence intervals crossing the red line are likely to have no effect. If the lower (left) end of a CI is higher than e.g. the white line for “small increase“, the effects of this substance were rated quite high. This was rarely the case. Most substances had ratings somewhere between “no“ and “small effect“, with some exceptions.

Overall Pleasantness

Most substances were rated as being somewhere between neutral and slightly pleasant, suggesting that detrimental effects are rare for nootropics. Three substances were rated as below neutral, but the confidence intervals are extremely large. On the other hand, some substances were rated as being more than “slightly“ pleasant: DMHA, Huperzine A, Selegiline and LSD.

Anxiety

According to the responses, anxiety is reduced most effectively by the following substances: L-Theanine, Tianeptine, CBD, Kava and Phenibut. All of these substances are well known for there anxiolytic, calming effects. On the other hand, anxiety is slightly increased by a number of well-known stimulants, like methylphenidate, caffeine, adderall and the finil group.

Focus

The most profound effects on focus were reported for Adrafinil, Caffeine, Phenylpiracetam, Modafinil, Armodafinil, Methylphenidate and, most of all, Adderall. Melatonin and GABA seem to decrease focus, but only very slightly.

Memory

Not many substances seem to improve memory. In fact, none of them were rated as leading to more than a “small increase“ in memory.

Motivation

A number of substances were rated as motivating. Most of them were stimulants. Melatonin, Bacopa monnieri and GABA seem to have slight detrimental effects on motivation.

Mood

LSD, Tianeptine, Phenibut and Adderall seem to improve mood. Remarkably, LSD microdoses were rated as having effects comparable to Tianeptine, which is an antidepressant.

Nootropics Dose

Participants asked for the dose in milligrams of the nootropics they have already taken. Most of them managed to answer in the required format. Minimum, average and maximum doses for all substances are listed in the table below.

Substance Minimum dose in mg Median dose in mg Maximum dose in mg L-Theanine 100 200 400 Bacopa 200 300 500 Caffeine 80 200 800 Curcumin 100 500 2500 Ashwagandha 300 500 1200 Rhodiola 50 300 700 St. John’s Wort 250 575 900 Kava NA NA NA Methylphenidate 10 20 200 Adderall 5 25 60 L-Deprenyl 10 10 10 Tyrosine 250 600 9000 NALT 60 500 500 Creatine 1250 5000 10000 CDP-Choline 150 300 2000 Alpha-GPC 125 300 1200 Carnitine/NALC 500 500 1000 Omega–3 300 1375 5000 Magnesium 100 300 1000 Modafinil 5 125 600 Armodafinil 75 150 150 Adrafinil 50 450 900 Piracetam 200 3100 8000 Phenylpiracetam 75 160 275 Aniracetam 90 800 2400 Oxiracetam 600 800 1500 Pramiracetam 100 700 1600 Coluracetam 15 55 200 Fasoracetam 100 22.5 60 Nefiracetam 250 250 250 Noopept 10 15 20 Semax .1 .6 2 Selank .1 .25 2 Doepezil 1 1 1 Huperzine A .085 1 5 Tianeptine 10 33 150 NSI–189 5 40 100 Melatonin .05 3 30 GABA 100 175 250 5-HTP 5 125 200 Black Seed Oil 30 265 500 Ginseng 50 325 600 Ginkgo 60 120 250 Nicotine 1 4 36 Sulbutiamine 200 500 1500 Uridine 10 250 600 Sacrosine 2000 2000 2000 Sunifram 10 20 20 BPC–157 .01 .25 200 Boswellia NA NA NA Guanfacine 2 2 2 DMHA 150 150 150 LSD Microdose .00005 10 25 CBD Oil 10 25 60 PRL–8–53 20 20 20 Agmatine 50 750 2000 Selegiline/Deprenyl 10 10 10 Phenibut 150 1000 3500 Lion’s Mane 200 800 3000

Correlations

Coming soon…