The wife of disgraced Hollywood producer Harvey Weinstein has announced she is leaving him.

Fashion designer Georgina Chapman described her husband’s behaviour as “unforgivable” following allegations of sexual misconduct from a host Hollywood stars.

In a statement to People magazine, Ms Chapman, 41, said she would be focusing on caring for the couple’s young children.

Harvey Weinstein left by wife as number of sexual assault allegations increase

“My heart breaks for all the women who have suffered tremendous pain because of these unforgivable actions,” she said.

“I have chosen to leave my husband. Caring for my young children is my first priority and I ask the media for privacy at this time."

Mr Weinstein 65 married Miss Chapman in 2007 and the couple have two children together, India Pearl, seven, and Dashiell Max Robert, four.

On Tuesday, Gwyneth Paltrow and Angelina Jolie joined a growing list of stars accusing the producer of sexual harassment, which has seen him dismissed from the Weinstein Company, which he co-founded.

Barack and Michelle Obama became the latest high-profile figures to condemn the producer, saying they were “disgusted” by the reports.

Harvey Weinstein and Meryl Streep (Getty) (Getty Images)

Weinstein has rejected many of the allegations and issued a vehement denial over three allegations of rape which emerged on Tuesday.

Speaking to the New York Times, Paltrow claimed Weinstein summoned her to his suite at a Beverly Hills hotel after he had hired her as a lead for 1996 hit Emma. She said he placed his hands on her and suggested they head to the bedroom for massages.

“I thought he was going to fire me,” Paltrow told the publication.

Pulp Fiction star Rosanna Arquette and French actress Judith Godreche made similar accusations, while Jolie said he made unwanted advances on her in a hotel room.

The producer had issued an apology for his behaviour prior to the rape allegations surfacing, saying he appreciated that the way he had behaved with colleagues in the past “has caused a lot of pain” and that he realised he “needed to be a better person”.

Stars including George Clooney, Meryl Streep, Kate Winslet, Dame Judi Dench and Benedict Cumberbatch have thrown their support behind the women accusing him of sexual harassment, while Ben Affleck said reading the rape allegations made him “sick”.