Warner Bros. Pictures has released the new trailer for the R-rated sci-fi thriller Splice, opening in theaters on June 4. Directed by Vincenzo Natali, the movie stars Adrien Brody and Sarah Polley.

In the film, Clive and Elsa are superstars of the genetic engineering world. They specialize in splicing together DNA from different animals to create fantastical new hybrids. The charismatic couple wants to use human DNA in a new hybrid  something that could yield astronomical medical benefits. The pharmaceutical company that funds their research, however, is more interested in exploiting their earlier triumphs for easier, short-term profit. Clive and Elsa secretly conduct their own experiment. The result is Dren: an amazing creature who exhibits an array of unexpected developments, both physical and intellectual. Dren exceeds their wildest dreams… and, ultimately, their most terrifying nightmare.