We thank L. Sanchez-Guardado from the Lois laboratory and the Thanos laboratory for providing mouse samples; S. Schindler for sectioning the tissue slices; J. Thomassie for help with data analysis; S. Shah for help with image analysis and input on the manuscript; K. Frieda for advice on the manuscript and help with making figures; and M. Thomsons, S. Chen and C. Lois for discussions. This project is funded by NIH TR01 OD024686, NIH HubMAP UG3HL145609, Paul G. Allen Frontiers Foundation Discovery Center and a Chan-Zuckerberg Initiative pilot grant.

Reviewer information

Nature thanks Samantha Morris, Arjun Raj and the other anonymous reviewer(s) for their contribution to the peer review of this work.