"I'm much more comfortable — and I think everyone that analyzes this knows that Hillary Clinton is in the ditch. We don't know how far into the ditch she's going to go, but she's not doing well," Priebus said during an an appearance on CNN's "Wolf."

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"I'd rather run against Hillary Clinton because she's defined, she's not liked, and in a popular cultural vote in America, that's a really important question," he added when presented with Clinton's large vote count lead.

Sanders has touted polling to argue he'd be a better general-election pick for Democrats than Clinton, who holds a big delegate lead and is hoping to blunt the independent Vermont senator's winning streak with a victory in the New York primary on Tuesday.

"I don't know what's going to happen with the FBI," Priebus said Friday, referring to the federal investigation surrounding Clinton's email arrangement as secretary of State. Clinton has predicted the issue won't impact her presidential bid, but Republicans view it as a major weakness.

The RNC chairman has argued before that Republicans would prefer to face Clinton in November. His latest comments come as Trump, the front-runner for the GOP nomination, remains deeply unpopular in polling among female voters, a demographic group Democrats hope to capitalize on in November.

Republicans have sought to turn their attention to Clinton amid days of renewed feuding from Trump, who has gone after the RNC and Priebus for operating a "rigged" nominating process.

"This is a very normal system that we have been using for many years."