A cyclist has been killed in a hit-and-run incident with a car in Sydney's west.

Emergency services were called to the intersection of Harry Avenue and Maud Street, Lidcombe, about 4.45pm on Tuesday, after reports a male cyclist had been hit by a car.

The man died at the scene. He has not been formally identified.

The car, described as a white or grey sedan, failed to stop after the incident, police said in a statement.

Officers from Auburn Police Area Command have established a crime scene and commenced inquiries.

Police are appealing for public assistance to locate both the car and its driver – who they described as a woman of Asian appearance believed to be aged in her 30s.

A cyclist was killed in a hit-and-run at the intersection of Harry Avenue and Maud Street, Lidcombe. Credit:Google Maps

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