(CNN) Hollywood has been outspoken against a controversial Georgia abortion law, and now the heads of three production companies are saying they will not film in the state.

Christine Vachon, chief executive officer of Killer Films; David Simon, creator of "The Wire" and "The Deuce" who heads Blown Deadline Productions; and Mark Duplass of Duplass Brothers Productions have come out in opposition to a newly signed law that would ban abortions in the state if a fetal heartbeat can be detected.

Georgia Gov. Brian Kemp signed the "heartbeat bill" into law Tuesday, and the American Civil Liberties Union has said it will challenge the new law in court. The law is set to go into effect January 1.

Georgia has been the location for the filming of multiple television shows and blockbuster films, including one of Marvel's biggest hits, "Black Panther."

Such films and the production of wildly popular TV series including "The Walking Dead" and "Stranger Things" have resulted in an estimated $2.7 billion pouring into the Southern state from direct spending via 455 productions, the governor's office announced last year.

Filmmakers J.J. Abrams and Jordan Peele released a joint statement Friday stating they'd stand "shoulder to shoulder with the women of Georgia" as their new show " Lovecraft Country " begins shooting in the state. They promised to donate 100% of their episodic fees to the ACLU of Georgia and Fair Fight Georgia , an election reform organization.

"Governor Kemp's 'Fetal Heartbeat' Abortion Law is an unconstitutional effort to further restrict women and their health providers from making private medical decisions on their terms. Make no mistake, this is an attack aimed squarely and purposely at women," the joint statement read. "We encourage those who are able to funnel any and all resources to these organizations."

On Thursday, Vachon, whose company has been behind such films as "Carol" and "Vox Lux," made her stand known on Twitter.

"Killer Films will no longer consider Georgia as a viable shooting location until this ridiculous law is overturned," she said.

Killer Films will no longer consider Georgia as a viable shooting location until this ridiculous law is overturned. — Christine Vachon (@kvpi) May 9, 2019

Simon tweeted, "I can't ask any female member of any film production with which I am involved to so marginalize themselves or compromise their inalienable authority over their own bodies."

I can't ask any female member of any film production with which I am involved to so marginalize themselves or compromise their inalienable authority over their own bodies. I must undertake production where the rights of all citizens remain intact. Other filmmakers will see this. https://t.co/V2xDPKiMpo — David Simon (@AoDespair) May 8, 2019

Can only speak for my production company. Our comparative assessments of locations for upcoming development will pull Georgia off the list until we can be assured the health options and civil liberties of our female colleagues are unimpaired. https://t.co/WTb0tj95zH — David Simon (@AoDespair) May 9, 2019

"I must undertake production where the rights of all citizens remain intact," he wrote. "Other filmmakers will see this."

Simon added, "Can only speak for my production company. Our comparative assessments of locations for upcoming development will pull Georgia off the list until we can be assured the health options and civil liberties of our female colleagues are unimpaired."

Duplass' company has a deal with Netflix, including the recent dramedy "Paddleton" starring Ray Romano and Duplass.

Don't give your business to Georgia. Will you pledge with me not to film anything in Georgia until they reverse this backwards legislation? — Mark Duplass (@MarkDuplass) May 9, 2019

"Don't give your business to Georgia," Duplass tweeted. "Will you pledge with me not to film anything in Georgia until they reverse this backwards legislation?"

But some in Hollywood have adopted a wait-and-see attitude.

A representative for the Motion Picture Association of America, which represents the five major film studios, said in a statement to CNN that it is monitoring legal efforts to reverse the controversial law.

"Film and television production in Georgia supports more than 92,000 jobs and brings significant economic benefits to communities and families," the statement said.

"It is important to remember that similar legislation has been attempted in other states, and has either been enjoined by the courts or is currently being challenged. The outcome in Georgia will also be determined through the legal process. We will continue to monitor developments."

The state has actively courted Hollywood, passing a 30% tax credit in 2008 for productions shot in Georgia.

In March, actress Alyssa Milano penned an open letter to Georgia House Speaker David Ralston and Kemp against the abortion legislation.

Dozens of other celebrities including Amy Schumer, Sean Penn, Alec Baldwin, Don Cheadle, Rosie O'Donnell, Patton Oswalt, Sarah Silverman and Mia Farrow signed the letter in support.

To @BrianKempGA & Speaker Ralston:

Attached, is an open letter signed by 50 actors against #HB481. On behalf of the undersigned--as people often called to work in GA or those of us contractually bound to work in GA--we hope you'll reconsider signing this bill. #HBIsBadForBusiness pic.twitter.com/DsOmAWYU2x — Alyssa Milano (@Alyssa_Milano) March 28, 2019

"This dangerous and deeply-flawed bill mimics many others which have already been deemed unconstitutional," said the letter, a copy of which Milano tweeted. "As men who identify as small-government conservatives, we remind you that government is never bigger than when it is inside a woman's body or in her doctor's office."

Around the same time the Writers Guild of America released a statement warning that passage of such legislation might cause Georgia to lose Hollywood productions.

Milano is filming Netflix's second season of "Insatiable" in Georgia and said in a statement Friday she will not return if filming continues in the state.

"'Insatiable' shoots in Georgia and I am currently contractually obligated to be there for another month," Milano said. "But I will do everything in my power to get as many productions as possible -- including 'Insatiable' -- to move out of this state which continues to put forth oppressive, hurtful policy that contradicts everything the entertainment industry stands for.

"And if 'Insatiable' doesn't move to another state, I will not be able to return to the show if we are blessed with a third season."