POLICE have renewed their appeal for help in finding two girls missing almost three days after reports the teens were seen in Mt Druitt yesterday.

The two 13-year-old girls - Teagan Lloyd and Skye Keenan - attended a school in the Rouse Hill area on Wednesday but failed to turn up to class at 12.30pm.

Police have been told their disappearance is out of character and they hold concerns for their welfare.

Information has now been provided to police that the girls were seen in the Mt Druitt area early yesterday morning at the home of an acquaintance. This sighting has been confirmed with a number of witnesses and police believe the girls may still be in the Mt Druitt/Quakers Hill area.

Teagan Lloyd is described as being of Caucasian appearance, about 155cm-160cm tall, with green eyes, long blonde hair and a thin build. She was last seen wearing dark blue shorts, and a white t-shirt.

Skye Keenan is described as being of Caucasian appearance with an olive complexion, about 160cm-165cm tall, with brown eyes, long brown hair, a thin build and has a New Zealand accent. She was last seen wearing a black t-shirt with white writing, and shorts.

Police and the girl's parents are appealing for anyone with information about the girls, or their whereabouts, to contact Crime Stoppers on 1800 333 000 or local police.

Det Supt Merryweather says considerable police resources are being dedicated to the investigation into the girls' whereabouts.

"The girls' families are extremely distressed and I urge anyone with information to contact police immediately, either by calling Quakers Hill Police or Crime Stoppers; callers to Crime Stoppers can remain anonymous if they wish," Det Supt Merryweather said.

"We are concerned by reports that information about the girls is circulating within the community but not being provided to police. If we are to resolve their disappearance we need to have all the information," he said.

Photographs of the girls are on the NSW Police Facebook site.