The daughter of controversial neurosurgeon Charlie Teo has been charged after a serious head-on crash that has left Comanchero bikie boss Jock Ross fighting for his life.

Police say that a 24-year-old woman was driving a Toyota LandCruiser at Lower MacDonald in the Hawkesbury on Wednesday when it collided with Mr Ross, 76, who was riding his motorbike.

Charlie Teo with his daughters, Katie and Nikki, right, who has been charged over the crash. Credit:Kate Geraghty

Nicola "Nikki" Teo was allegedly driving on the wrong side of Settlers Road for 100 or 200 metres, with a child in the car's front passenger seat at the time of the crash.

Police have yet to speak to that person, Crash Investigation Unit's Detective Inspector Katie Orr said on Thursday.