A man has been arrested following the unsolved 2007 murder of Melbourne mother of-three Cindy Crossthwaite.

Ms Crossthwaite, 41, was found dead inside her Andrew Street home in Melton South just after 4pm on June 20.

A 55-year-old man, from Footscray, was arrested by police at a Tottenham business at about 8am on Wednesday.

It followed a police appeal which offered $1million for information about Ms Crossthwaite's death.

The man was charged with one count of murder and will face Melbourne Magistrates' Court on Wednesday.

An autopsy revealed the mother died from head injuries.

A 55-year-old man has been arrested following the unsolved 2007 murder of Melbourne mother of-three Cindy Crossthwaite (pictured)

The mother's body was discovered by her father, Philip Crossthwaite, after she failed to pick up her two eldest children, then aged 10 and eight, from school.

She was last seen dropping them off at school earlier in the day.

Her youngest son, who was just 15-months old at the time, was at home when she was killed, police said.

The murder was so vicious it took DNA and fingerprints to identify her, despite her family already knowing the worst.

Ms Crossthwaite, 41, was found murdered inside her Andrew Street home in Melton South just after 4pm on June 20

Ms Crossthwaite's daughter Jasmine and Phillip begged for answers about her death on the 10th anniversary of her murder in 2017.

'I want to know what happened to mum. I want to find out why they would, someone would do that to her. I want them to know how much it's affected everyone,' she told Nine News.

'She was just a beautiful angel. The pain is so deep and she can never be replaced.'

Police said the media coverage at the time helped detectives uncover new information about the case.

'One person provided specific information to police about Cindy's murder including a claim that more than one person was involved and that Cindy may have been stalked in the weeks leading up to her death,' officers said in a release.

'As a result of this, detectives believe a number of people are likely to have intimate knowledge of this murder.'

'They are also appealing for those people who provided information to contact police again.'

Ms Crossthwaite was also reportedly receiving death threats before her murder, with someone claiming they were going to shoot her and snap her neck.