A team from the Centers of Disease Control and Prevention has arrived in Sioux Falls to help with the Smithfield Foods coronavirus hotspot, which has become the biggest single-source of cases in the United States.

Eighty of South Dakota's 180 new COVID-19 cases are Smithfield Foods employees, bringing the total to 518 Smithfield employees who have tested positive. There are also now 126 total cases of non-employees that became infected when they came into contact with an employee of the meat processor, according to the South Dakota Department of Health.

© Erin Bormett / Argus Leader Smithfield Foods, Inc. employees wear masks as they leave at the end of their shift on Wednesday, April 8, at the food processing plant in Sioux Falls.

The 518 employees and 126 non-employees connected to Smithfield makes it the largest cluster in the country (644), according to tracking by the New York Times. The previous top cluster was 585 cases aboard the USS Theodore Roosevelt in Guam.

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Smithfield announced on Sunday that it would be closing its Sioux Falls plant indefinitely on Wednesday. The plant has 3,700 employees.

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We've been in frequent communication with @VP Pence, @SecretarySonny, and the CEO of Smithfield. We're working together on a plan to get the plant open as soon as it’s safe. A CDC team arrives today to help us assess the situation on the ground. Additional details soon. (3/4) — Governor Kristi Noem (@govkristinoem) April 15, 2020

Gov. Kristi Noem tweeted on Wednesday that the CDC team was arriving on Wednesday to help the state assess the situation.

Health Secretary Kim Malsam-Rysdon said they requested the CDC bring in occupational health experts to help the state understand Smithfield's coronavirus situation and what the company can do to protect its workers. Smithfield is cooperating with the state and they look forward to the mitigation efforts so the plant can reopen, Malsam-Rysdon said.

This is a developing story. Stay with argusleader.com for updates.

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COVID-19 coverage: Here's a map of coronavirus cases in Minnesota

United States hot spots

Smithfield Foods meatpacking plant; Sioux Falls, S.D. 644

Aboard the U.S.S. Theodore Roosevelt; Guam, 585

Cook County Jail; Chicago, 524

Parnall Correctional Facility; Jackson, Mich., 212

Soldiers' Home in Holyoke; Holyoke, Mass., 194

Source: New York Times

This article originally appeared on Sioux Falls Argus Leader: Smithfield Foods now largest coronavirus hot spot in US, CDC in Sioux Falls to investigate