Thousands of people flooded Civic Center Plaza and Market Street for the second annual Women's March on Saturday, with signs that ranged in tone from motivational to bawdy.

Riffs on pop culture abounded, with messages like "This episode of Black Mirror sucks" and "Trump took Barb," a "Stranger Things" reference.

Anatomy was one popular theme; Trump's s--hole comments and nostalgia for the days of the Obama administration were others.

Many women were veterans of last year's march — some in San Francisco, some elsewhere.

"I marched in Washington last year, and it was a highlight moment of my life," said Marcy Levine,65, of San Anselmo, who carried a sign that said, "We are not ovary-acting."

Many said they looked forward to a possible "blue wave" in 2018's midterm elections.

"I came out today for the empowerment of women everywhere and the future of our little girls," said Erika McGee, 30, of San Francisco, adding that she hoped that in the future, more women would run for whatever elected offices they choose without stigma or fear.

She carried a sign decorated to look like a mirror, rimmed in flowers and inspirational Post-it notes with messages like, "I heart you," "You are beautiful" and "Time heals all wounds."

"It's more quiet than I assumed it would be," she said of the march's tone. "I like it. It's a somber walk. We understand what we're walking for."

Many were marching as families. One toddler sat on the ground, playing with a sign that read, "When I grow up, I don't want to be paid more just because I was born white and male!"

One 6-year-old girl wore a sign around her neck that said simply, "DON'T PISS ME OFF."

Some who weren't able to march last year were excited to join in.

"Last year, I had just had a baby, and with the rain, it wasn't a good idea. But I so, so wanted to come," said Jeannie Jies, a resident of San Francisco wearing a hat that said "ITMFA" (short for "Impeach the Mother F— Already").

Her daughter, 6-year-old Audra, was marching down Market Street in a Wonder Woman costume.

Asked why she joined the march, she looked thoughtful for a minute, then said with a little shrug, "I don't like Donald Trump."

Others came with old friends. Shelley Sandusky, 51, came to the march with David Diaz, 52, her friend since sixth grade. She carried a sign that said, "GRAB MY P— TRUMP, I DARE YOU!" waterproofed for last year's rainy march and decorated with a picture of her cat Cleo, wide-eyed and angry-looking.

"This was her reaction to the election," she said. "This was the face she made when he won."

Click through the gallery above to see funny, memorable signs from the march

Filipa Ioannou is an SFGATE staff writer. Email her at fioannou@sfchronicle.com and follow her on Twitter