1. Nestler, E. J. Epigenetic mechanisms of drug addiction. Neuropharmacology 76, 259–268 (2014). Pt B.

2. Everitt, B. J. & Robbins, T. W. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 8, 1481–1489 (2005).

3. Heilig, M., Epstein, D. H., Nader, M. A. & Shaham, Y. Time to connect: bringing social context into addiction neuroscience. Nat. Rev. Neurosci. 17, 592–599 (2016).

4. Marlatt, G. A., Baer, J. S., Donovan, D. M. & Kivlahan, D. R. Addictive behaviors: etiology and treatment. Annu. Rev. Psychol. 39, 223–252 (1988).

5. Bardo, M. T., Neisewander, J. L. & Kelly, T. H. Individual differences and social influences on the neurobehavioral pharmacology of abused drugs. Pharmacol. Rev. 65, 255–290 (2013).

6. Miczek, K. A., Yap, J. J. & Covington, H. E. III. Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake. Pharmacol. Ther. 120, 102–128 (2008).

7. Nader, M. A. & Banks, M. L. Environmental modulation of drug taking: nonhuman primate models of cocaine abuse and PET neuroimaging. Neuropharmacology 76, 510–517 (2014). Pt B.

8. Stitzer, M. L., Jones, H. E., Tuten, M. & Wong, C. Community reinforcement approach and contingency management interventions for substance abuse. in: Handbook of Motivational Counseling: Goal-Based Approaches to Assessment and Intervention with Addiction and Other Problems. W. M. Cox & E. Klinger, eds. (John Wiley & Sons, Ltd, Chichester, UK, 2011).

9. Banks, M. L. & Negus, S. S. Insights from preclinical choice models on treating drug addiction. Trends Pharmacol. Sci. 38, 181–194 (2017).

10. Ahmed, S. H., Lenoir, M. & Guillem, K. Neurobiology of addiction versus drug use driven by lack of choice. Curr. Opin. Neurobiol. 23, 581–587 (2013).

11. Caprioli, D., Zeric, T., Thorndike, E. B. & Venniro, M. Persistent palatable food preference in rats with a history of limited and extended access to methamphetamine self-administration. Addict. Biol. 20, 913–926 (2015).

12. Venniro, M., Zhang, M., Shaham, Y. & Caprioli, D. Incubation of methamphetamine but not heroin craving after voluntary abstinence in male and female rats. Neuropsychopharmacology 42, 1126–1135 (2017).

13. Ahmed, S. H. Trying to make sense of rodents’ drug choice behavior. Prog. Neuropsychopharmacol. Biol. Psychiatry 87, 3–10 (2018). Pt A.

14. Azrin, N. H. et al. Follow-up results of supportive versus behavioral therapy for illicit drug use. Behav. Res. Ther. 34, 41–46 (1996).

15. Vanderschuren, L. J., Achterberg, E. J. & Trezza, V. The neurobiology of social play and its rewarding value in rats. Neurosci. Biobehav. Rev. 70, 86–105 (2016).

16. Solinas, M., Chauvet, C., Thiriet, N., El Rawas, R. & Jaber, M. Reversal of cocaine addiction by environmental enrichment. Proc. Natl. Acad. Sci. USA 105, 17145–17150 (2008).

17. Zlebnik, N. E. & Carroll, M. E. Prevention of the incubation of cocaine seeking by aerobic exercise in female rats. Psychopharmacology (Berl.) 232, 3507–3513 (2015).

18. Smith, M. A. Peer influences on drug self-administration: social facilitation and social inhibition of cocaine intake in male rats. Psychopharmacology (Berl.) 224, 81–90 (2012).

19. Strickland, J. C. & Smith, M. A. The effects of social contact on drug use: behavioral mechanisms controlling drug intake. Experiment Clin. Psychopharmacol. 22, 23–34 (2014).

20. Zernig, G., Kummer, K. K. & Prast, J. M. Dyadic social interaction as an alternative reward to cocaine. Front. Psychiatry 4, 100 (2013).

21. Fritz, M. et al. Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats. Addict. Biol. 16, 273–284 (2011).

22. Deroche-Gamonet, V., Belin, D. & Piazza, P. V. Evidence for addiction-like behavior in the rat. Science 305, 1014–1017 (2004).

23. Zimmer, B. A., Oleson, E. B. & Roberts, D. C. The motivation to self-administer is increased after a history of spiking brain levels of cocaine. Neuropsychopharmacology 37, 1901–1910 (2012).

24. Li, X., Zeric, T., Kambhampati, S., Bossert, J. M. & Shaham, Y. The central amygdala nucleus is critical for incubation of methamphetamine craving. Neuropsychopharmacology 40, 1297–1306 (2015).

25. Gründemann, J. & Lüthi, A. Ensemble coding in amygdala circuits for associative learning. Curr. Opin. Neurobiol. 35, 200–206 (2015).

26. Venniro, M. et al. The anterior insular cortex→central amygdala glutamatergic pathway is critical to relapse after contingency management. Neuron 96, 414–427.e8 (2017).

27. Ahmed, S. H. & Koob, G. F. Transition from moderate to excessive drug intake: change in hedonic set point. Science 282, 298–300 (1998).

28. Piazza, P. V. & Deroche-Gamonet, V. A multistep general theory of transition to addiction. Psychopharmacology (Berl.) 229, 387–413 (2013).

29. Kawa, A. B., Bentzley, B. S. & Robinson, T. E. Less is more: prolonged intermittent access cocaine self-administration produces incentive-sensitization and addiction-like behavior. Psychopharmacology (Berl.) 233, 3587–3602 (2016).

30. Grimm, J. W., Hope, B. T., Wise, R. A. & Shaham, Y. Neuroadaptation. Incubation of cocaine craving after withdrawal. Nature 412, 141–142 (2001).

31. Caprioli, D. et al. Effect of the novel positive allosteric modulator of metabotropic glutamate receptor 2 AZD8529 on incubation of methamphetamine craving after prolonged voluntary abstinence in a rat model. Biol. Psychiatry 78, 463–473 (2015).

32. Dong, Y., Taylor, J. R., Wolf, M. E. & Shaham, Y. Circuit and synaptic plasticity mechanisms of drug relapse. J. Neurosci. 37, 10867–10876 (2017).

33. Balleine, B. W. & Dickinson, A. Goal-directed instrumental action: contingency and incentive learning and their cortical substrates. Neuropharmacology 37, 407–419 (1998).

34. Pickens, C. L. et al. Neurobiology of the incubation of drug craving. Trends Neurosci. 34, 411–420 (2011).

35. Kim, J., Zhang, X., Muralidhar, S., LeBlanc, S. A. & Tonegawa, S. Basolateral to central amygdala neural circuits for appetitive behaviors. Neuron 93, 1464–1479.e5 (2017).

36. Bossert, J. M., Marchant, N. J., Calu, D. J. & Shaham, Y. The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research. Psychopharmacology (Berl.) 229, 453–476 (2013).

37. Solinas, M., Thiriet, N., Chauvet, C. & Jaber, M. Prevention and treatment of drug addiction by environmental enrichment. Prog. Neurobiol. 92, 572–592 (2010).

38. Augier, E. et al. A molecular mechanism for choosing alcohol over an alternative reward. Science 360, 1321–1326 (2018).

39. Wise, R. A. & Koob, G. F. The development and maintenance of drug addiction. Neuropsychopharmacology 39, 254–262 (2014).

40. Caprioli, D. et al. Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence. J. Neurosci. 37, 1014–1027 (2017).

41. Thiel, K. J. et al. Environmental enrichment counters cocaine abstinence-induced stress and brain reactivity to cocaine cues but fails to prevent the incubation effect. Addict. Biol. 17, 365–377 (2012).

42. Chauvet, C., Goldberg, S. R., Jaber, M. & Solinas, M. Effects of environmental enrichment on the incubation of cocaine craving. Neuropharmacology 63, 635–641 (2012).

43. Schoenbaum, G., Chang, C. Y., Lucantonio, F. & Takahashi, Y. K. Thinking outside the box: orbitofrontal cortex, imagination, and how we can treat addiction. Neuropsychopharmacology 41, 2966–2976 (2016).

44. Heyman, G. M. Addiction and choice: theory and new data. Front. Psychiatry 4, 31 (2013).

45. Waldorf, D., Reinarman, C. & Murphy, S. Cocaine Changes: the Experience of Using and Quitting. (Temple University Press, Philadelphia, PA, USA, 1991).

46. Monterosso, J. & Ainslie, G. The behavioral economics of will in recovery from addiction. Drug Alcohol. Depend. 90, S100–S111 (2007). Suppl 1.

47. Tourigny, S. C. Some new dying trick: African American youths “choosing” HIV/AIDS. Qual. Health Res. 8, 149–167 (1998).

48. Higgins, S. T. et al. Community reinforcement therapy for cocaine-dependent outpatients. Arch. Gen. Psychiatry 60, 1043–1052 (2003).

49. Lash, S. J., Burden, J. L., Monteleone, B. R. & Lehmann, L. P. Social reinforcement of substance abuse treatment aftercare participation: Impact on outcome. Addict. Behav. 29, 337–342 (2004).

50. Insel, T. R. Digital phenotyping: technology for a new science of behavior. J. Am. Med. Assoc. 318, 1215–1216 (2017).

51. Theberge, F. R. et al. Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biol. Psychiatry 73, 729–737 (2013).

52. Li, X. et al. Incubation of methamphetamine craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue-activated fos-expressing dorsal striatal neurons. J. Neurosci. 35, 8232–8244 (2015).

53. Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates. Sixth edn., (Academic Press, San Diego, CA, USA, 2008).

54. Calu, D. J., Chen, Y. W., Kawa, A. B., Nair, S. G. & Shaham, Y. The use of the reinstatement model to study relapse to palatable food seeking during dieting. Neuropharmacology 76, 395–406 (2014). Pt B.

55. Venniro, M., Caprioli, D. & Shaham, Y. Animal models of drug relapse and craving: From drug priming-induced reinstatement to incubation of craving after voluntary abstinence. Prog. Brain. Res. 224, 25–52 (2016).

56. Wolf, M. E. Synaptic mechanisms underlying persistent cocaine craving. Nat. Rev. Neurosci. 17, 351–365 (2016).

57. Krasnova, I. N. et al. Incubation of methamphetamine and palatable food craving after punishment-induced abstinence. Neuropsychopharmacology 39, 2008–2016 (2014).

58. Marchant, N. J., Khuc, T. N., Pickens, C. L., Bonci, A. & Shaham, Y. Context-induced relapse to alcohol seeking after punishment in a rat model. Biol. Psychiatry 73, 256–262 (2013).

59. Pelloux, Y. et al. Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions. Addict. Biol. 23, 699–712 (2018).