Treasurer Josh Frydenberg has warned of a "significant impact on the Australian economy" from the coronavirus as seafood businesses fear they will have to close their doors.

Already the virus is costing tourism $1 billion a month and damaging other industries too due to a lack of more than 106,000 international students.

Mr Frydenberg told Channel Nine's Today Show on Thursday his job was to "make sure that the economic harm to the economy is mitigated" but would not say whether the budget, which has been impacted by bushfires and drought, will still be in surplus.

Treasury is crunching numbers to indicate the full scale of the impact on the economy and the federal budget, from the disease which has so far claimed more than 400 lives worldwide, and resulted in 15 Australians testing positive to the virus.