Protesters aiming to derail Donald Trump’s White House run descended on Trump Tower on Wednesday to give the GOP presidential nominee an earful about his vulgar p—y tape.

About 70 people, almost all women, chanted “GOP, hands off me,” “Un-endorse Donald Trump,” “P—y fights back” and “Trump thinks he runs this town, p—y came to shut it down.”

One sign at the Fifth Avenue demonstration had a picture of a cat baring its teeth, and read: “This pussy votes.”

“It’s not about lewd language, it’s about sexual assault,” said Nadya Stevens, 33, one of the protest organizers. “It seems like this has reached a tipping point where people are finally saying this is not OK, and we just want to be here to topple this campaign.”

Trump has been reeling since 2005 footage emerged on Friday showing him speaking in lewd, offensive terms about women who, he claimed, were so starstruck by his presence that they let him “grab them by the p—y.”

Protester Jane Pool, 53, brought her 11-year-old daughter to the demonstration in hopes of showing her what’s not permissible to say or do.

“We needed to come here just for her to see we can say this is not OK,” Pool said. “Her father, my husband, sat down with the kids around the table (after the ‘Access Hollywood’ tape emerged) and told them, ‘This is not OK, this is not how adults talk.’ But not all kids have someone to say that to them. They think, ‘Wow, this guy is on this huge level, and this is the way he talks.’ ”

She added: “The kids are paying attention.”

Despite being one of the protest organizers, Stevens said she was miffed that it took Trump’s offensive 2005 “Access Hollywood” interview to finally move the needle against him.

Trump has survived a series of controversial comments — such as proposing a ban against Muslims entering the US and characterizing Mexican immigrants as rapists and drug dealers.

“It seems like it was OK for Trump to attack Muslims, to attack immigrants, to attack China, but when he attack white women, that was when it was not OK,” Stevens said. “We wanted to encourage all women to speak up and defend themselves.”

Additional reporting by David K. Li