Psychologistdiscusses her new book Mastermind: How to Think like Sherlock Holmes.sleep apnoea, DNA sonnets and beleaguered mackerel

This week, author and psychologist Maria Konnikova reveals how Arthur Conan Doyle's fictional sleuth can help us maximise our brain power. Click here to read the Guardian's review of Mastermind: How to Think Like Sherlock Holmes.

Put your questions to Maria in our live Q&A from 1.30pm to 2.30pm GMT on Wednesday 6 February

Alok Jha also meets Prof Anita Simonds, a consultant in respiratory medicine at Royal Brompton Hospital to discuss the incredible advances in her field and why sleep apnoea is on the increase. Prof Simonds also talks about the history of noninvasive ventilation – the subject of one of a series of free, public inaugural lectures at Imperial College London that run into April.

Alok is joined by Guardian science correspondent Ian Sample and Adam Vaughan, editor of our environment website, to discuss this week's science news: the overfishing of mackerel, encoding Shakespeare's sonnets and Martin Luther King's "I have a dream" speech in DNA, and the growing problem of antibiotic resistance.

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