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Bookmakers have Theresa May at 5/1 to resign or be ousted as Prime Minister by the end of the day after a fierce backlash to her Brexit deal plunged her future into doubt.

Several ministers have resigned including high-profile figures Dominica Raab and Esther McVey.

Betfair has given odds of 5/1 that the Prime Minister will leave today.

She is odds-on at 4/5 not to see out the year, according to Betfair, who also install Home Secretary Sajid Javid as favourite at 6/1 to succeed Mrs May if she resigns.

Bookies Fitzdares have former Foreign Secretary and staunch Brexiteer Boris Johnson as the most likely candidate to step into the Prime Minister's shoes.

The ministers most likely to resign next are Penny Mordaunt, Michael Gove and David Mundell, according to Betfair.

Mrs May gave a fighting statement in the Commons on Thursday morning to try to rally support for her deal.

Odds for Theresa May’s replacement

Boris Johnson – 5/1

Sajid Javid – 6/1

David Davis – 13/2

Dominic Raab – 9/1

Jacob Rees-Mogg – 9/1

Michael Gove – 9/1

Jeremy Hunt – 11/1

Amber Rudd – 40/1

Odds provided by Fitzdares.

Which minister most likely to resign next?

Penny Mordaunt - 2/5

Michael Gove - 4/7

David Mundell - 8/11

Theresa May 5/1

Sajid Javid - 11/2

Karen Bradley - 13/2

Liam Fox - 8/1

Chris Grayling - 10/1

James Brokenshire - 12/1

David Gauke - 12/1

Jeremy Hunt - 14/1

Greg Clark - 14/1

Baroness Evans of Bowes Park - 16/1

Alun Cairns - 16/1

Odds provided by Betfair.

'Truly make or break time for Theresa​'

One bookmaker suggests odds for Mrs May to face a vote of no confidence are now at 3/1 - the shortest it has been to date.

Bookmakers.tv was forced to cut the odds on Mrs May being replaced as 94 per cent of bets coming in have been on the Prime Minister to vacate Number 10 by the end of November.

Meanwhile, the odds are evens for that no Brexit deal is agreed by April 1 2019, whilst another EU referendum before the end of 2019 is now 5/2 having been cut from 3/1.

"This is truly make or break time for Theresa," William Woodhams, CEO of Fitzdares, said. "The money suggests she will be gone by Christmas and we think that Boris Johnson, Michael Gove and Jeremy Hunt will throw their hat into the ring to take over.

“Rees-Mogg will suck up a lot of the publicity but will not win.

"We are tipping Amber Rudd as the outsider who may surprise everyone."

Katie Baylis, a spokeswoman for Betfair, added: “Before the announcement, May was 24/1 to leave her post this year, but in the aftermath of the draft text being released, those double-figure odds have been shortening by the hour and have gone from 3/1 last night to odds-on at 4/5 this morning.

“If that were to happen Sajid Javid is considered by Betfair as the likeliest candidate to lead the Tory party at 6/1.

“Those hoping for a ‘People’s Vote’ on the final Brexit Deal may be buoyed to see a move on a Referendum in 2020 from 7/2 to 15/8, but these odds could shorten even more across the day as we see more reaction and opposition to the deal."