Philadelphia Eagles running back Ryan Mathews is questionable for Monday's game against the New York Giants.

Mathews was added to the team's injury report Friday with a groin issue. If he's unable to play, Darren Sproles would step into the primary backup role behind DeMarco Murray.

Rookie wide receiver Nelson Agholor, meanwhile, will miss his first game of the season after injuring his left leg in the Eagles' 39-17 victory over the New Orleans Saints. Linebackers Mychal Kendricks (hamstring) and Kiko Alonso (knee), and defensive end Brandon Bair (groin) have also been ruled out.