Akiba Y.

Kato S.

Katsube K.

Nakamura M.

Takeuchi K.

Ishii H.

Hibi T. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet β cells modulates insulin secretion in rats. Biochem. Biophys. Res. Commun. 321 : 219-225 View in Article Scopus (136)

PubMed

Crossref

Google Scholar

Bernardini N.

Neuhuber W.

Reeh P.W.

Sauer S.K. Morphological evidence for functional capsaicin receptor expression and calcitonin gene-related peptide exocytosis in isolated peripheral nerve axons of the mouse. Neuroscience. 126 : 585-590 View in Article Scopus (70)

PubMed

Crossref

Google Scholar

Caterina M.J.

Leffler A.

Malmberg A.B.

Martin W.J.

Trafton J.

Petersen-Zeitz K.R.

Koltzenburg M.

Basbaum A.I.

Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science. 288 : 306-313 View in Article Scopus (2599)

PubMed

Crossref

Google Scholar

Colbert H.A.

Smith T.L.

Bargmann C.I. OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J. Neurosci. 17 : 8259-8269 View in Article PubMed

Google Scholar

Coschigano K.T.

Holland A.N.

Riders M.E.

List E.O.

Flyvbjerg A.

Kopchick J.J. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology. 144 : 3799-3810 View in Article Scopus (359)

PubMed

Crossref

Google Scholar

Dong M.-Q.

Venable J.D.

Au N.

Xu T.

Park S.K.

Cociorva D.

Johnson J.R.

Dillin A.

Yates 3rd, J.R. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Science. 317 : 660-663 View in Article Scopus (241)

PubMed

Crossref

Google Scholar

Emeson R.B.

Hedjran F.

Yeakley J.M.

Guise J.W.

Rosenfeld M.G. Alternative production of calcitonin and CGRP mRNA is regulated at the calcitonin-specific splice acceptor. Nature. 341 : 76-80 View in Article Scopus (99)

PubMed

Crossref

Google Scholar

Flurkey K.

Papaconstantinou J.

Miller R.A.

Harrison D.E. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. USA. 98 : 6736-6741 View in Article Scopus (593)

PubMed

Crossref

Google Scholar

Gram D.X.

Hansen A.J.

Wilken M.

Elm T.

Svendsen O.

Carr R.D.

Ahrén B.

Brand C.L. Plasma calcitonin gene-related peptide is increased prior to obesity, and sensory nerve desensitization by capsaicin improves oral glucose tolerance in obese Zucker rats. Eur. J. Endocrinol. 153 : 963-969 View in Article Scopus (64)

PubMed

Crossref

Google Scholar

Gram D.X.

Ahrén B.

Nagy I.

Olsen U.B.

Brand C.L.

Sundler F.

Tabanera R.

Svendsen O.

Carr R.D.

Santha P.

et al. Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes. Eur. J. Neurosci. 25 : 213-223 View in Article Scopus (98)

PubMed

Crossref

Google Scholar

Holzenberger M.

Dupont J.

Ducos B.

Leneuve P.

Géloën A.

Even P.C.

Cervera P.

Le Bouc Y. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature. 421 : 182-187 View in Article Scopus (1456)

PubMed

Crossref

Google Scholar

Houtkooper R.H.

Argmann C.

Houten S.M.

Cantó C.

Jeninga E.H.

Andreux P.A.

Thomas C.

Doenlen R.

Schoonjans K.

Auwerx J. The metabolic footprint of aging in mice. Sci. Rep. 1 : 134 View in Article Scopus (249)

PubMed

Crossref

Google Scholar

Huising M.O.

van der Meulen T.

Vaughan J.M.

Matsumoto M.

Donaldson C.J.

Park H.

Billestrup N.

Vale W.W. CRFR1 is expressed on pancreatic β cells, promotes β cell proliferation, and potentiates insulin secretion in a glucose-dependent manner. Proc. Natl. Acad. Sci. USA. 107 : 912-917 View in Article Scopus (49)

PubMed

Crossref

Google Scholar

Jordan S.D.

Krüger M.

Willmes D.M.

Redemann N.

Wunderlich F.T.

Brönneke H.S.

Merkwirth C.

Kashkar H.

Olkkonen V.M.

Böttger T.

et al. Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat. Cell Biol. 13 : 434-446 View in Article Scopus (330)

PubMed

Crossref

Google Scholar

Kogire M.

Ishizuka J.

Thompson J.C.

Greeley Jr., G.H. Inhibitory action of islet amyloid polypeptide and calcitonin gene-related peptide on release of insulin from the isolated perfused rat pancreas. Pancreas. 6 : 459-463 View in Article Scopus (58)

PubMed

Crossref

Google Scholar

Kovács K.A.

Steullet P.

Steinmann M.

Do K.Q.

Magistretti P.J.

Halfon O.

Cardinaux J.-R. TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity. Proc. Natl. Acad. Sci. USA. 104 : 4700-4705 View in Article Scopus (131)

PubMed

Crossref

Google Scholar

Kurosu H.

Yamamoto M.

Clark J.D.

Pastor J.V.

Nandi A.

Gurnani P.

McGuinness O.P.

Chikuda H.

Yamaguchi M.

Kawaguchi H.

et al. Suppression of aging in mice by the hormone klotho. Science. 309 : 1829-1833 View in Article Scopus (1114)

PubMed

Crossref

Google Scholar

Mair W.

Morantte I.

Rodrigues A.P.C.

Manning G.

Montminy M.

Shaw R.J.

Dillin A. Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB. Nature. 470 : 404-408 View in Article Scopus (222)

PubMed

Crossref

Google Scholar

Marsch R.

Foeller E.

Rammes G.

Bunck M.

Kössl M.

Holsboer F.

Zieglgänsberger W.

Landgraf R.

Lutz B.

Wotjak C.T. Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J. Neurosci. 27 : 832-839 View in Article Scopus (249)

PubMed

Crossref

Google Scholar

McBeth J.

Silman A.J.

Macfarlane G.J. Association of widespread body pain with an increased risk of cancer and reduced cancer survival: a prospective, population-based study. Arthritis Rheum. 48 : 1686-1692 View in Article Scopus (80)

PubMed

Crossref

Google Scholar

Mezey É.

Tóth Z.E.

Cortright D.N.

Arzubi M.K.

Krause J.E.

Elde R.

Guo A.

Blumberg P.M.

Szallasi A. Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. Proc. Natl. Acad. Sci. USA. 97 : 3655-3660 View in Article Scopus (666)

PubMed

Crossref

Google Scholar

Moreno H.

Burghardt N.S.

Vela-Duarte D.

Masciotti J.

Hua F.

Fenton A.A.

Schwaller B.

Small S.A. The absence of the calcium-buffering protein calbindin is associated with faster age-related decline in hippocampal metabolism. Hippocampus. 22 : 1107-1120 View in Article Scopus (28)

PubMed

Crossref

Google Scholar

Nakanishi M.

Hata K.

Nagayama T.

Sakurai T.

Nishisho T.

Wakabayashi H.

Hiraga T.

Ebisu S.

Yoneda T. Acid activation of Trpv1 leads to an up-regulation of calcitonin gene-related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade: a potential mechanism of inflammatory pain. Mol. Biol. Cell. 21 : 2568-2577 View in Article Scopus (65)

PubMed

Crossref

Google Scholar

Noble M.D.

Romac J.

Wang Y.

Hsu J.

Humphrey J.E.

Liddle R.A. Local disruption of the celiac ganglion inhibits substance P release and ameliorates caerulein-induced pancreatitis in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 291 : G128-G134 View in Article Scopus (29)

PubMed

Crossref

Google Scholar

Park T.J.

Comer C.

Carol A.

Lu Y.

Hong H.-S.

Rice F.L. Somatosensory organization and behavior in naked mole-rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain. J. Comp. Neurol. 465 : 104-120 View in Article Scopus (72)

PubMed

Crossref

Google Scholar

Pettersson M.

Ahrén B.

Böttcher G.

Sundler F. Calcitonin gene-related peptide: occurrence in pancreatic islets in the mouse and the rat and inhibition of insulin secretion in the mouse. Endocrinology. 119 : 865-869 View in Article Scopus (131)

PubMed

Crossref

Google Scholar

Poyner D.R.

Soomets U.

Howitt S.G.

Langel U. Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br. J. Pharmacol. 124 : 1659-1666 View in Article Scopus (33)

PubMed

Crossref

Google Scholar

Selman C.

Lingard S.

Choudhury A.I.

Batterham R.L.

Claret M.

Clements M.

Ramadani F.

Okkenhaug K.

Schuster E.

Blanc E.

et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 22 : 807-818 View in Article Scopus (352)

PubMed

Crossref

Google Scholar

Selman C.

Tullet J.M.A.

Wieser D.

Irvine E.

Lingard S.J.

Choudhury A.I.

Claret M.

Al-Qassab H.

Carmignac D.

Ramadani F.

et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science. 326 : 140-144 View in Article Scopus (749)

PubMed

Crossref

Google Scholar

Szallasi A.

Nilsson S.

Farkas-Szallasi T.

Blumberg P.M.

Hökfelt T.

Lundberg J.M. Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Res. 703 : 175-183 View in Article Scopus (178)

PubMed

Crossref

Google Scholar

Tanaka H.

Shimaya A.

Kiso T.

Kuramochi T.

Shimokawa T.

Shibasaki M. Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist. Life Sci. 88 : 559-563 View in Article Scopus (33)

PubMed

Crossref

Google Scholar

Torrance N.

Elliott A.M.

Lee A.J.

Smith B.H. Severe chronic pain is associated with increased 10 year mortality. A cohort record linkage study. Eur. J. Pain. 14 : 380-386 View in Article Scopus (146)

PubMed

Crossref

Google Scholar

Woods J.A.

Wilund K.R.

Martin S.A.

Kistler B.M. Exercise, inflammation and aging. Aging Dis. 3 : 130-140 View in Article PubMed

Google Scholar