Senate Minority Leader Charles Schumer Chuck SchumerPelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' 3 reasons why Biden is misreading the politics of court packing Cruz blocks amended resolution honoring Ginsburg over language about her dying wish MORE (D-N.Y.) on Tuesday said that Labor Secretary Alexander Acosta Alex Alexander AcostaFederal litigator files complaint alleging Labor secretary abused his authority Appeals court to review legality of Epstein plea deal Appeals court finds prosecutors' secret plea agreement with Epstein didn't break law MORE should resign over a 2008 plea deal involving financier Jeffrey Epstein and that if he doesn't, President Trump Donald John TrumpSteele Dossier sub-source was subject of FBI counterintelligence probe Pelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Trump 'no longer angry' at Romney because of Supreme Court stance MORE should fire him.

"I am calling on Secretary Acosta to resign,” Schumer said during a Senate floor speech. “It is now impossible for anyone to have confidence in Secretary Acosta's ability to lead the Department of Labor. If he refuses to resign, President Trump should fire him.”

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Schumer's demand for Acosta to resign comes as an increasing number of Democrats, including members of his caucus, are calling on the Labor secretary to step down.

"Acosta chose to let him off easy. This is not acceptable. We cannot have as one of the leading appointed officials in America someone who has done this," Schumer added of the plea deal received by Epstein.

In addition to Acosta resigning, Schumer said on Tuesday that the Justice Department's Office of Professional Responsibility, which is investigating the plea deal, should make its findings public and that Trump needs to explain past statements he's made about Epstein.

Federal prosecutors unsealed new sex trafficking charges against Epstein on Monday, alleging abuse of dozens of female minors. He has denied all charges.

The charges are putting a new spotlight on the 2008 plea deal that Acosta, then a U.S. attorney in Florida, approved with Epstein that enabled him to serve 13 months in “custody with work release."

Acosta has defended the 2008 plea deal, arguing that it ensured Epstein would serve jail time, register as a sex offender and pay damages to victims.

But Schumer — calling Epstein's alleged behavior "sickening," "appalling" and "despicable" — on Tuesday argued that Acosta gave him a "sweetheart deal" despite "overwhelming evidence."

"Epstein should have been behind bars years ago," Schumer said. "No one can figure out why Mr. Epstein was able to persuade U.S. Attorney Acosta not to prosecute."