Live in West Virginia or Kentucky? You’re more likely than most Americans to die of heart disease, cancer or a drug overdose.

Residents of Arkansas, Louisiana, and Mississippi are most likely to succumb to diabetes, while people in the Rocky Mountain states of Idaho, Wyoming and Colorado have lower rates of both cancer and heart disease.

A new county-by-county breakdown of what kills people in the U.S. finds big differences.

Perhaps most startling, death rates from drug overdoses shot up by 1,000 percent in clusters of counties in six states: Kentucky, West Virginia, Ohio, Indiana, western Pennsylvania, and east-central Missouri.

Age-standardized mortality rate from cardiovascular diseases, 2014. JAMA

“We found huge variation in all the leading causes of death,” said Dr. Christopher Murray at the Institute for Health Metrics and Evaluation (IHME) at the University of Washington in Seattle.

“There’s more than 20 years difference across the communities.”

Some of the findings are not surprising.

“Heart disease is particularly high in the southeast of the United States,” said Murray, who has pioneered many different ways to crunch health statistics. Experts know lifestyle — poor diet, a lack of exercise and less access to good medical care — are mostly to blame.

Related: Death by Zip Code

Other patterns may depend on economic and social factors.

Age-standardized mortality rate from self-harm and interpersonal violence, 2014 JAMA

“The highest levels, for example, for violent death, from suicide and homicide, are in the West of the U.S.,” Murray said. “The highest death rates from drug use disorders are in West Virginia and eastern Kentucky and New Mexico.”

Health experts have known there are big geographical differences in health across the U.S. The Centers for Disease Control and Prevention has called it death by zip code. The new analysis, published in the Journal of the American Medical Association, takes it to a deeper level, and looks at changes in death rates since 1980 using individual death certificates for 80 million people.

Related: Want to Live a Long Life? Be like Utah

Here’s a look:

Mental and substance use disorders caused 1 percent of deaths between 1980 and 2014.

Highest mortality: Eastern Kentucky; southwestern West Virginia; Alaska; North Dakota; South Dakota, and on with Native American reservations in southwestern states. Mortality rates went up by 1,000 percent in Kentucky, West Virginia, Ohio, Indiana, western Pennsylvania, and east-central Missouri.

Lowest mortality: Nebraska; Iowa; eastern South Dakota.

Related: Heroin Deaths Quadruple Across U.S.

Heart disease remains the No. 1 killer

Highest mortality: Seen in a band stretching from Oklahoma to Mississippi and in eastern Kentucky. Lowest mortality: Central Colorado; the border are of Idaho, Montana, and Wyoming.

Between 1980 and 2014, deaths from cardiovascular disease fell by 50 percent.

Highest mortality: Along the southern half of the Mississippi River, while mortality rates from self-harm and interpersonal violence were elevated in southwestern counties, and mortality rates from chronic respiratory disease were highest in counties in eastern Kentucky and western West Virginia

Cancer — the No. 2 cause of death

Very high mortality: Along the southern half of the Mississippi River; eastern Kentucky; western West Virginia; western Alaska.

Low mortality: States stretching from Idaho and Wyoming to western Texas

Death rates from cancer across the U.S. fell by 20 percent from 1980 to 2014.

Suicide and homicide are the 8th leading cause of death

Highest mortality rates: Alaska; on Native American reservations in North Dakota and South Dakota; the Southwest

Lowest mortality rates: Upper Midwest; New England; southwesternTexas; southern California