Those on the sanctions list include the secretary of Iran’s Supreme National Security Council, the deputy chief of staff of the armed forces and the commander of the Basij militia, which has been responsible for a brutal crackdown on anti-government protests.

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“We are striking at the heart of the regime’s inner security apparatus,” said Secretary of State Mike Pompeo, appearing at the White House lectern with Treasury Secretary Steven Mnuchin.

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The sanctions were widely anticipated, as President Trump had publicly said he would impose them in response to the attack. No Americans or Iraqis were killed, and Trump said in a statement Wednesday that Iran “appears to be standing down.”

Iran’s economy is already burdened by sanctions on more than 1,000 Iranian individuals, companies and organizations that have been imposed since Trump withdrew from the 2015 nuclear deal with Iran as part of a “maximum pressure” campaign to get Tehran to change its policies. Some Iranians have been hit by sanctions more than once, in what a U.S. official called a “wraparound effect.”

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Mnuchin said Friday’s action would cut off billions of dollars to the government.

The latest round of sanctions are more broad-based than previous ones that have focused mostly on Iran’s oil, banking and shipping sectors. The new sanctions blacklist Iran’s entire construction, mining, textiles and manufacturing sectors. Anyone doing business with them will face sanctions as well.

Brian Hook, the special envoy for Iran, predicted the sanctions would have a major impact on the leadership, because they target the sectors that have kept Iran’s economy “on life support.”

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“We have this regime that is facing its worst financial crisis, and its worst political unrest in its 40-year history,” he said in a call with reporters. “And so the regime has very bad options right now. They are in a state of panicked aggression.”

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Iranian President Hassan Rouhani said last month that the U.S. “economic war” of sanctions had deprived Tehran of $100 billion in oil revenue and another $100 billion in investments. By some estimates, Iran’s economy contracted more than 10 percent last year.

The economic stranglehold has forced Iran to adopt a “budget of resistance” that includes ending some subsidies and raising fuel prices. The budget cuts have helped spur widespread protests and a government crackdown. But the pain has mostly been felt by ordinary Iranians instead of government officials.

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The Trump administration says it believes the sanctions will push the Iranian government to renegotiate the nuclear deal, curtail its missile development program and stop its sponsorship of militias in neighboring countries.

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“We want Iran to behave like a normal nation,” Pompeo told reporters, reprising a demand he has made repeatedly over the past year and a half since he outlined 12 ways the Iranian government must change before sanctions can be eased.

Though Pompeo and other administration officials have denied they are seeking regime change, imposing sanctions on officials involved in the crackdown against protesters signaled Washington’s support of those in Iranian society most discontented with their government. State Department officials have said as many as 1,500 Iranians may have been killed in the protests, though independent human rights group put the number in the hundreds. Many thousands have been imprisoned.

The security force that put down the protests was the Basij, a volunteer force whose commander, Gholamreza Soleimani, was added to the sanctions list Friday.

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“It’s also really important for us to go after Iran shock troops, the Basij, which have been murdering Iranians who have been fighting for their freedom,” Hook said. “So when we do this, it has a substantive effect, but it also signals to the Iranian people that we stand with them and their demands for a more representative government.”

Though the maximum pressure campaign has not accomplished any of its goals in getting the ruling clerics in the Iranian government to change their foreign policy, administration officials say they are confident it will prevail.

Pompeo said the effort has denied Tehran the resources needed to advance what he called “its destructive foreign policy.” Oil revenue is down 80 percent, and the government, he said, has no access to 90 percent of its foreign currency reserves.

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“They’ve got real challenges,” he said of the decisions facing the Iranian government. “Do you underwrite Hezbollah? Do you pick Hamas? Do you underwrite the Shia militias in Iraq? Or do you allow your people to have the opportunity to live the life they want and grow your economy? Those are the difficult choices that the regime is facing.”

Foreign diplomats and Iran analysts say that Tehran shows little sign it is willing to buckle under U.S. pressure. But Pompeo and Mnuchin said there will be no sanctions relief unless Tehran does an about-face.

“As long as Iran’s outlaw ways continue, we will continue to impose sanctions,” Pompeo said.

Behnam Ben Taleblu, an Iran analyst with the Foundation for Defense of Democracies, lauded the broader sanctions as a way to further drive down Iran’s export earnings that could be diverted in part to proxy militias.