Police have confirmed two young sisters have been found dead at a home in Melbourne's north east.

Neighbours reported hearing two women howling outside the home on Longmuir Road in Watsonia on Sunday afternoon.

Police were called to the scene about 2:30pm (AEST) and found the bodies of two girls at the house.

Fire brigade crews and paramedics spent 30 minutes trying to revive the girls but they died at the scene.

A man has been arrested and is assisting police with their inquiries.

Assistant Commissioner Andrew Crisp said the sisters were under the age of 10.

"The person taken into custody, the suspect, and the two deceased girls were known to each other and again I'm not going to expand on detail in relation to that at this point in time," he said.

"It goes without saying this is a tragic set of circumstances that has impacted on the family and there were a number of family members here at the time.

"It's first of all impacted on friends, neighbours, and also on members of the fire brigade and the ambulance services and members of Victoria Police that have attended the scene."

Mr Crisp said a number of people were present at the home at the time of the incident.

"We're trying to work into who lives where. It's very early days in terms of this investigation," he said.

"If anyone does have information in relation to circumstances that have happened in Longmuir Road, they can contact Crime Stoppers."