Dartmouth College is trying to learn more about the brain in order to help people who smoke marijuana and who sometimes:

· Hear things that others don't hear

· See things that others don't see

· Have scary or unusual thoughts





We have two research studies:



CLOCS: This is a medication study comparing two medications to see if they change the amount of marijuana people smoke. This study lasts about 4 months and involves

· Weekly meetings with the research staff

· Answering questions about substance use and current symptoms

· Half the people in the study will get a medicine called “clozapine” and the other half will get a medicine called “risperidone.”

People in the study will not know which type of pill they are getting.



D2: This study uses MRI scans to better learn how marijuana affects the brain. The study lasts about 3-4 weeks and involves:

· Brief check-ins with study staff near their home about 3 times a week.

· Not using drugs or alcohol while in the study.

· Going to Dartmouth Hitchcock Medical Center (DHMC) in Lebanon 4 times over a period of 3-4 weeks.

· Having their head scanned in an MRI scanner.

· Being monitored closely while taking dronabinol (a THC related medication) or smoking marijuana once .



Other information:

· Participants will be reimbursed for their time and travel.

· If participants do not have transportation, the study will provide it.

· All information is kept private



If you or someone you know is interested in being a part of one of these studies, then answer the few short questions in this confidential survey to see if you might qualify. If you have questions or prefer to speak to us by phone, you can call 1-877-491-4451.