Another bloody weekend in Baltimore saw seven people shot - two of them fatally - in the span of just 16 hours.

The string of shootings kicked off at about 9.30pm on Saturday when officers responding to a call in West Baltimore found a 39-year-old man dead of a gunshot to the head.

Some two hours later, a 28-year-old man was shot on Milton Street in East Baltimore.

That man was taken to the hospital and is in serious condition, according to the Baltimore Police Department.

At around 1.22pm police received reports of a shooting in a neighborhood just north of Penn Station.

A 27-year-old man suffered a gunshot wound and was taken to the hospital.

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Seven people were shot, two of them fatally, in the span of 16 hours from Saturday night to Sunday afternoon in Baltimore, Maryland, bringing the crime ridden the crime-ridden city's homicide toll so far in 2019 up to 240 (file photo)

The string of shootings kicked off at about 9.30pm on Saturday when officers responding to a call in West Baltimore found a 39-year-old man dead of a gunshot to the head

As dawn broke on Sunday morning, another call about gunfire came in just before 7am.

Police responding to Gold Street found a 26-year-old man with gunshot wounds to the head, neck and torso. He was pronounced dead in the hospital.

An hour later police responded to a double shooting in South Baltimore on Filbert Street.

A 21-year-old man who'd been shot in the back was taken to the hospital. His condition was unknown.

Soon after, a 23-year-old man stumbled into an area hospital with gunshot wounds to the arm, leg and groin.

Authorities believe both men were injured when an unknown suspect opened fire on them near Pennington Avenue.

On Sunday afternoon, another victim, a 36-year-old man, walked into an area hospital with a gunshot wound to the leg.

Police said the incident happened around 1.40pm but that they do not know other details at this time as the victim is being uncooperative.

None of the seven victims have been named and all of the incidents remain under investigation.

A 26-year-old man was killed dead after being shot in the torso, neck and head on Gold Street (pictured) just before 7am Sunday, according to police

The two shooting fatalities raised Baltimore's homicide death toll so far in 2019 to 240, according to the Baltimore Sun.

The violent 16 hours came after Labor Day weekend saw three people killed and 18 others injured in shootings Friday through Monday, according to Baltimore police.

Mike Callow, who was near the Sunday morning shooting on Pennington Avenue, says the violence is out of control.

'I think there's a lot of senseless killings out here,' Callow told Fox45.

'It's very upsetting. Nobody wants to see nobody get killed.

'Everybody has a value in life and purpose in life and it's just sad seeing people die every day throughout the city.'

The latest fatalities put 'Charm City' on track for a fifth consecutive year with 300 murders

A forensics worker is pictured collecting evidence near the scene of a shooting in April

At this rate, the Maryland metropolis dubbed 'Charm City' will have a fifth straight year with more than 300 murders.

Baltimore is rated one of the most dangerous cities by the FBI, having seen a steep increase in violent crime since 2015.

That year the homicide rate soared amid fierce unrest over the death of Freddie Gray, a black man who died in police custody. Gray's death became a rallying cry for Baltimore residents who harbor deep distrust for local authorities.

In 2016 the US Department of Justice's Civil Rights Division released a report accusing the Baltimore Police Department of racial discrimination and excessive force.

The city and the federal government subsequently reached a 'consent decree', a set of policing reforms to be enforced by a federal judge.

However, the crime rate in Baltimore continued its climb.

In 2017, the city recorded its highest per-capita homicide rate ever with 342 murders, or 56 per 100,000 people. Those numbers put Baltimore well above any other city in America.

President Donald Trump (left) will visit Baltimore on Thursday to speak at the 2019 House Republican Conference Member Retreat Dinner. The trip comes weeks after Trump attacked Democratic Rep Elijah Cummings (right) and called his Baltimore-area district 'rat infested'

President Donald Trump is scheduled to visit Baltimore on Thursday to speak at the 2019 House Republican Conference Member Retreat Dinner.

His visit comes a few weeks after he made multiple attacks on Rep Elijah Cummings and the Democrat's Baltimore-area district.

Trump called Cummings' 7th Congressional District a 'disgusting, rat and rodent-infested mess' where 'no human being would want to live'.

Many Democrats labeled the president's remarks about the majority-black city as racist, a charge Trump vehemently denied.

Cummings responded by telling Trump: 'Come to Baltimore. Do not just criticize us, but come to Baltimore and I promise you, you will be welcomed.'

Anti-Trump protests are expected to be held outside the retreat at the Baltimore Marriott Waterfront Hotel in Harbor East.