In what may be a battle of defenses, Matt Barkley who will likely replace Josh Allen (concussion) will need to be protected heavily. The Titans are currently ranked tied-5th for total sacks (13). The Bills O-line is ranked 17th allowing sacks at a rate of 6.37%

Bills defence is ranked 5th giving up 15.8 points per game. The D must find a way to sack Marcus Mariota who escaped being sacked last week but was sacked 17 times in his three games prior to that

The secondary will need to shut down Titans’ rookie A.J. Brown who averages 22.3 yards per catch for the season (10 receptions)

Bills are ranked 4th in the NFL for rush yards per game (147.2) and Frank Gore is 12th individually for rush yards (273). Gore may be relied upon if Allen is confirmed to sit this one out

How the Titans Win …

Mariota needs to remains aggressive. He has the longest current active passing streak without an interception in the league and has set a franchise record for most passes without an interception (169)

Titans currently rank 6th in the NFL for third-down conversions allowed with 15 successful first-downs on 49 attempts (30.6%)

The pass rush pressure Matt Barkley who has thrown 10 TD’s and 19 INT in his career. Titans are currently tied-5th in total sacks (13)