While most overdose death increases were from opioids, there were also drastic increases in deaths by antidepressants, the report said. From 1999 to 2017 among women aged 30-34, and 40-49, the rate doubled, the report said. And it rose by 300% among 55-59 year old women, and by almost 400% among women aged 60 to 64, the CDC said.