Child protection is a whole community problem and the SA Government can not guarantee all children's safety, the Premier says, as he resists calls to step down from his position.

The Child Protections System Royal Commission handed down its findings earlier this week, which included a recommendation to split Families SA from the Education Department.

Premier Jay Weatherill told 891 ABC Adelaide while the Government was willing to act on recommendations from the royal commission, there was no guarantee there would be no further failings in the future.

"Because of the nature of human behaviour, people are going to make these incredibly difficult decisions about whether to remove a child or to leave a child in the family and try and support that child," he said.

"Because future human behaviour is unknowable, from time to time we will get that wrong and we will be back here explaining ourselves.

"I can't guarantee the safety of every single child, what I can guarantee is we will do everything we possibly can to keep every child safe."

Amalgamating the two departments was one of the first reforms Mr Weatherill made when he came into office.

He has conceded he made the wrong call but will not stand down from his position despite demands from the Opposition.

"This is a failing that I have to accept that I was wrong about that," he said.

"I believed that this larger agency was actually the best place to be able to address that question and I was wrong about that."

While he acknowledged there were fundamental issues within Families SA, he said a "whole community" approach was needed to protect children in the future.

"One of the reasons this agency feels under threat is because the community is very quick to blame the last person that was associated in the lives of these families," he said.

"The truth remains that these people who actually put their hands up to be child protection workers do so with the best will in the world to protect our children and we have to support them and what we need to do is find other ways in which we can support families.

"This is a whole of community responsibility, you can't just hang it on one agency and say you're responsible for keeping every child safe."

The Government has begun an international recruitment process for a new chief executive of the separate child protection agency.