Radio oddest of odd couples, John Safran and Father Bob Maguire, are quitting their quirky Triple J show after 10 years.

The pair have had a famously prickly on-air relationship on their Sunday night program in which they chew over wide-ranging issues concerning ethics, religion and politics.

God bothering ... John Safran and Father Bob are calling it quits.

Announcing the end of the long-running show, Safran revealed his next project would examine Islam in Australia.

"Dear listeners and Father Bob, you know we live in a very secular country and people look to me to try and understand religion," he said. "If you're one of those people I have good news and I have bad news.