Jayron Hosley has studied T.Y. Hilton, the Colts big-play receiver who each week seems to make a catch far down the field, and has determined he’s spotted, if not a weakness, a vulnerability to keep Hilton in check.

“I think he kind of has trouble getting off the press,’’ Hosley told The Post on Friday, referring to press coverage up at the line of scrimmage. “He’s a quick guy, fast guy, but coming off the line, you can get him off the line in the press, playing good, sound press technique. You got to be disciplined, play ball, be aggressive, at the same time just be aware of what’s going on, watch a lot of film on this guy. You got to play instinctive and at the same time play with your defense, play your leverages. You know guys are gonna make plays, that’s what they’re there for. Limit that and just play ball, man.’’

Hosley figures to play a key role Monday night. He’s inherited the nickel back role with the season-ending injuries to Walter Thurmond and Trumaine McBride. That means Hosley will get a heavy dose of Hilton, who has emerged as a top threat in his third NFL season. He leads the league with 866 receiving yards, is tied for fourth in catches (53) and is first in receiving first downs as a remarkable 42 of his 53 receptions have been for first downs.

With age and injuries catching up to Reggie Wayne and free-agent addition Hakeem Nicks not showing much of the burst he had with the Giants, Hilton is Andrew Luck’s go-to receiver. The Giants have Prince Amumakara, a hobbled Dominique Rodgers-Cromartie – who was able to practice this week on a limited basis – and Hosley as their top three corners, and Hosley will get the bulk of the work in the slot against Hilton. Physically, it should be a solid matchup, as Hilton (5-foot-9, 178 pounds) and Hosley (5-foot-10, 178 pounds) are virtually the same size.

“I told him today, I thought yesterday he showed a lot of quickness and speed,’’ Tom Coughlin said. “I’d like to see it pretty much on every play. He does have cover ability, he’s just got to do it over and over again consistently. He’s our guy. If he starts at nickel, he’s our guy. Let’s go.’’

Hosley arrived in 2012 as a third-round draft pick from Virginia Tech, a rookie brimming with confidence, but it hasn’t worked out the way the team or the player envisioned. Hosley battled injuries his first two years, playing in 23 games (seven starts) and missed the first four games this season while he was suspended for violating the league’s policy on illegal drugs.

“I’m still confident in myself, I still believe in myself,’’ Hosley said. “If I lost my confidence I wouldn’t be here right now, trust me. Lot of things came into play. I’ve been through a lot, injuries, off the field things. I’m in a much better place. I feel more focused, I feel good, healthy, mentally tougher, mentally strong. I’m in a much better place. More ready.’’