A female doctor is recovering in hospital after being stabbed and doused in petrol in Port Macquarie by a man she briefly dated.

Police were called to the home in Magnolia Place in Port Macquarie after reports a woman had been stabbed.

Angela Jay, 28, was allegedly stabbed several times by Paul Lambert, 36, before she managed to drag herself to a neighbour’s house.

The qualified doctor talked her neighbour through first aid until paramedics arrived.

The alleged offender fled the scene, and police attempted to arrest him on the Pacific Highway near Coffs Harbour, about 150 kilometres away, after a pursuit.

Angela Jay (left) was allegedly stabbed several times by Paul Lambert, whom she briefly dated. (9NEWS)

Officers initially tried to Taser Lambert, but fired multiple shots when he did not relent.

“He turned and confronted police, and attacked them with a knife,” Assistant Commissioner Jeff Loy said.

CPR was administered to Lambert but he died at the scene.

It is believed the pair had only known each other for two months, and had met on the dating app Tinder.

Ms Jay had taken out an AVO against Lambert just three days before she was stabbed, police said.