A Sydney hospital security guard will spend tonight behind bars charged with the stabbing death of his wife.

Sixty-year-old Mourad Kerollos, from Panania, is accused of repeatedly stabbing his wife and leaving her body just metres from Prince of Wales Hospital in Sydney’s east.

Gihan Kerollos was found unresponsive with stab wounds on Barker Street about 8.45pm last night. The 47-year-old mother-of-three had just finished a shift at the hospital.

Police allege Mr Kerollos was parked in the family’s station wagon on Barker Street waiting for his wife but had no intention of driving her home.

9News has learned Mr Kerollos “came prepared” with a knife found in a pool of blood on the street.

Police earlier described the incident as "domestic" related.

“I never expected it from him. Never, never in my life,” one of Mr Kerollos’ neighbours told 9News.

“I feel very bad because this street is a very nice street. Everybody really supports each other.”

Mr Kerollos was arrested at the scene and did not apply for bail.