Synopsis

A plethora of genetic, dietary and pharmacological interventions can extend healthy lifespan in laboratory animals, and can delay or ameliorate diverse aging-related diseases. Many of the signalling pathways involved are evolutionarily conserved, and are starting to be implicated in human aging. This raises the intriguing possibility of performing preventative medicine against the chronic diseases of our time by targeting the main risk factor for all of them, namely aging. Two important current challenges in the field are (1) to understand the downstream pathways by which longevity interventions combat age-related loss of function and pathology, and (2) to translate the findings into the extension of human healthspan.

This third meeting will continue to explore these topics, with particular emphasis on the systemic environment, mitochondria, biomarkers and frailty, immune aging and the protective effects of natural products.

For those interested, this meeting follows the Mitochondria: From Basic Biology to Mechanisms of Disease Conference, taking place from 27 February - 02 March 2019 at the same venue.

Student Offer

Take advantage of this fantastic opportunity for students! Register an academic at the standard rate of $1,922 and bring a student for only $850. Unfortunately, Postdocs are not eligible. Both registration packages include; accommodation for the 03, 04, 05 March 2019 (on a shared basis for students) and a 24hour all-inclusive food and beverage package for the conference period. Academic registrations must be completed by 14 December 2018. Once registered, please contact Meredith Willmott to obtain a special registration link for your student.

Confirmed Plenary Speakers:



Darren Baker (Mayo Clinic)

IMPLICATING SENESCENT CELLS TO NEURODEGENERATIVE PATHOLOGIES

Shin-ichiro Imai (Washington University in St. Louis)

Thomas Langer (Max Planck Institute)

PROTEOLYTIC CONTROL OF MITOCHONDRIAL PLASTICITY

Janet Lord (University of Birmingham)

PREVENTING AND OVERCOMING IMMUNESENESCENCE

Joan Mannick (resTORbio)

TORC1 INHIBITION AS AN IMMUNOTHERAPY TO DECREASE INFECTIONS IN THE ELDERLY

Dennis Villareal (Baylor College of Medicine)

LIFESTYLE INTERVENTIONS TO REVERSE FRAILTY IN OLDER ADULTS WITH OBESITY

Confirmed Invited Speakers:

Thiruma Arumugam (National University of Singapore)

INTERMITTENT METABOLIC SWITCHING AND BRAIN HEALTH

Bonnie Blomberg (University of Miami)

PROGRESS IN AGING AND IMMUNITY

Steven Braithwaite (Alkahest)

MULTIMODAL THERAPEUTICS FROM THE PLASMA PROTEOME FOR AGE-RELATED DISORDERS

Katrin Chua (Stanford University)

CHROMATIN REGULATION AND GENOME MAINTENANCE BY HUMAN SIRTUINS SIRT6 AND SIRT7

Kaare Christensen (University of Southern Denmark)

LONGEVITY ENRICHED FAMILIES. HOW DID THEY SUCCEED?

Peter Fedichev (GERO)

Vadim Gladyshev (Harvard Medical School)

Jan Gruber (Yale NUS College)

LEVERAGING PATHWAY SYNERGY FOR PHARMACOLOGICAL INTERVENTIONS TO EXTEND HEALHTY LIFESPAN

Vera Gorbunova (University of Rochester)

FROM COMPARATIVE BIOLOGY TO ANTI-AGING INTERVENTIONS

Jesús Gil (MRC London Institute of Medical Sciences)

Marcia Haigis (Harvard Medical School)

MITOCHONDRIAL METABOLISM AND AGING

Jackie Han (PICB Shanghai)

Gerald de Haan (European Research Institiute for the Biology of Ageing)

NEW GENES INVOLVED IN HEMATOPOIETIC STEM CELL AGING

Heinrich Jasper (Genentech)

AGE RELATED STEM CELL DYSFUNCTION IN BARRIER EPITHELIA - STRATEGIES FOR INTERVENTION

Dudley Lamming (University of Wisconsin)

THE REGULATION OF METABOLIC HEALTH AND LONGEVITY BY SPECIFIC DIETARY MACRONUTRIENTS

William Mair (Harvard T.H. Chan)

RNA SPLICING AND LONGEVITY

Darcie Moore (University of Wisconsin)

Richard Miller (University of Michigan)

THE MOUSE ITP: CURRENT PROGRESS AND PROJECTS or CAP-INDEPENDENT TRANSLATION OF SELECTIVE MRNAS IN LONG-LIVED MUTANT MICE

Nicolas Musi (UT Health, San Antionio)

Thomas Nystrom (University of Gothenburg)

HUNTING FOR GENES GENERATING CELLULAR AGE ASYMMETRY

Arlan Richardson (University of Oklahoma Health Science Center)

IS REDUCING NECROPTOSIS AN POTENTIAL INTERVENTION IN AGING?

Dave Schubert (Salk Institute)

GERONEUROPROTECTORS: EFFECTIVE GEROPROTECTORS FOR THE BRAIN

Thomas Weldon (Ponce de Leon Health, Inc)

PONCE DE LEON HEALTH

Kai Zhou (Buck Institute)

Target Audience

Basic scientists in the field of aging research using animal models.

Human researchers interested in biomarkers of aging

Clinical trials specialists in aging and associated diseases.

Scientists and other professionals developing aging interventions.

Investors looking to enter this new space

Educated public

Educational Need

The aging field encompasses a wide range of biology, involving many model organisms and, with respect to mammals, the involvement of many tissues. In addition, translational strategies to modify the rate of aging range from lifestyle change to drugs and, more recently stem cell-based therapeutics. As such, there is an abiding need to bring together scientists across diverse fields with the purpose of providing a clear overview of the state of basic research in aging and the development of translational strategies. The goal is to create cross-fertilization between scientists in different areas, accelerating the development of interventions that extend human healthspan.