A jury has found a tourist bus driver guilty of negligence after he ploughed the vehicle into Melbourne’s infamous Montague Street Bridge.

Jack Aston failed to see at least five warning signs before he hit the structure, seriously injuring his passengers in February 2016.

Jack Aston has been found guilty of negligence. (9NEWS)

The 55-year-old Ballarat man had just picked up 14 passengers from the Melbourne Convention Centre when he was handed paperwork from the tour guide.

Confused about the area and where he was headed, he told police he'd never been to Albert Park before and didn't recall seeing or hitting the bridge.

Mr Aston ploughed into the overpass with the impact ripping off part of the vehicle's roof.

The court heard Mr Aston failed to see at least five warning signs before the crash. (9NEWS)

The tourist bus ploughed into Montague Street bridge. (9NEWS)

The County Court today heard he failed to heed five warning signs including flashing lights and one on the bridge declaring low clearance.

Six of those on-board the bus suffered serious injuries ranging from head and spinal fractures, along with broken bones.

Aston pleaded not guilty to six charges of negligently causing serious injury. But today the jury in the County Court disagreed.

A plea hearing has been set for December 3. (9NEWS)

Six passengers suffered serious injuries. (9NEWS)

As the verdicts were handed down, Mr Aston’s wife wept loudly in the courtroom before being comforted by relatives.

A member of the offender’s legal team also became emotional in what the judge has described as a difficult trial.

A plea hearing has been set for December 3.