Comedian Garry Shandling, star of Showtime’s It’s Garry Shandling’s Show and HBO’s The Larry Sanders Show, died Thursday, TMZ reports. He was 66.

Per the site, Shandling passed away after he was transported from his home to a Los Angeles-area hospital.

On Larry Sanders, Shandling was a five-time Emmy Award nominee for Lead Actor, and he grabbed gold once (with Peter Tolan) for Outstanding Writing. The comedian also amassed three American Comedy Awards across his career, 12 CableACE Awards, two Golden Globe nods and a pair of Writers Guild Award noms (both for Larry Sanders).

In addition to his two starring roles, Shandling appeared in Caroline in the City and The X-Files, and was a frequent fill-in host for Johnny Carson on The Tonight Show. He also wrote episodes of Sanford and Son, The Harvey Korman Show and Welcome Back, Kotter, and was a three-time Emmys host in 2000, 2003 (as one of 11 comedian emcees) and 2004.