It's rare for an NFC team to dislike an AFC team so much, but for Carolina Panthers fans, they have a serious distaste for two teams from the opposite conference in particular.

Firstly, like most NFL fans, the Panthers have an extreme dislike for the New England Patriots. Not only due to their seemingly always-winning ways, but also because New England was responsible for breaking the hearts of every Panthers fan in Super Bowl 38, the team's first-ever appearance in The Big Game that ended in a gut-wrenching 32-29 loss on Adam Vinatieri's game-winning field goal with four seconds left in Houston, Texas.

Twelve years later, the Panthers made their way to the Super Bowl yet again, and this time - a bit opposite of the 2003 season when Carolina just got extremely hot at the right time - the 2015 Panthers seemed like the clear-cut best team in the NFL. After starting the year 14-0, the Panthers ran through the Seahawks and Cardinals to earn their second appearance in the Super Bowl in the 50th edition.

On the other side? The defensive-led Denver Broncos, who were quarterbacked by an aging Peyton Manning and possessed a rather lackluster offense. The Panthers were considered the favorites going into the game, but some man named Von Miller put an end to that quickly.

With Denver leading 3-0 early in the game, Miller's forced fumble led to a Malik Jackson fumble recovery in the end zone, giving the Broncos a 10-0 lead they wouldn't relinquish in the ultimate 24-10 victory. Miller finished the game with 2.5 sacks and was named the Super Bowl MVP. Panthers fans have hated him to this day as a result, and that's why Miller was recently named 'The Greatest Villain' in Carolina Panthers history in a recent article done by FanSided.

"It may not have been a sustained villainy like others on this list, but rest assured even to this day that Carolina Panthers players and fans can still see Von Miller in their nightmares," author Erik Lambert wrote. "That’s how devastating his performance in Super Bowl 50 was. He alone took a 15-1 team into his hands and flattened it like a pancake until their spirits were broken. He was everywhere in that game. Not only did Miller sack Cam Newton 2.5 times and forced two critical fumbles that all but won the Denver Broncos the game, he also made six tackles and deflected a pass. To understand, the Panthers averaged 40 points in their first two playoff games. They managed 10 in the Super Bowl, and that was mostly because of Miller.

"Then, just to rub salt in the wound, the Broncos and Panthers met again in the 2016 season opener. Miller sacked Newton again and helped to force the key turnover that handed Denver the win. Carolina would spiral to a 6-10 season."

While more obvious names like Michael Vick, Drew Brees, Matt Ryan or even Viniatieri could have been easy choices on paper, it's tough to go against Miller. The pass-rushing specialist has only squared off against the Panthers three times, but he's recorded 4.5 sacks of Newton in the process, and etched his name in the minds of Panthers fans forever along the way.