Senate Democrats' campaign arm is going after Sen. Dean Heller Dean Arthur HellerOn The Trail: Democrats plan to hammer Trump on Social Security, Medicare Lobbying World Democrats spend big to put Senate in play MORE (R-Nev.) and Sen. Jeff Flake Jeffrey (Jeff) Lane FlakeJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Republican former Michigan governor says he's voting for Biden Maybe they just don't like cowboys: The president is successful, some just don't like his style MORE (R-Ariz.) for their votes Tuesday to begin debate on ObamaCare repeal legislation.

The Senate's vote Tuesday — which passed by a razor-thin margin and required a tie-breaking vote from Vice President Pence — marked a step toward the Republicans' goal of ending the healthcare law.

Democratic Senatorial Campaign Committee (DSCC) spokesman David Bergstein said in a statement that Heller has shown the people of Nevada they can't "trust him to stand up for their care."

"Today he sealed his fate as another desperate, self-serving Washington politician too interested in helping himself to stand up for the people who elected him," Bergstein said in the statement.

He referred to Heller as a "deciding vote."

"His deciding vote today – to force Nevadans to pay more for less care, to drive up premiums by 20 percent, to impose an age tax on older Americans and to strip away coverage for pre-existing conditions – will be one of his last," the statement said.

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The DSCC also targeted Flake for his vote.

Bergstein said in a statement the Arizona Republican voted to "give big insurance companies and the wealthiest few another tax break."

"Unfortunately, Senator Flake’s vote is perfectly in line with his record: for years he’s championed plans that would increase health care costs and sold out working families to benefit himself," Bergstein said in the statement.

"Senator Flake’s vote is a defining demonstration of why he cannot be trusted to stand up for Arizonans in the Senate, and in 2018 voters will hold him accountable.”

Heller and Flake are considered the most vulnerable Senate Republicans on the ballot in 2018, a nationwide map that generally favors the GOP. Hillary Clinton Hillary Diane Rodham ClintonJoe Biden looks to expand election battleground into Trump country Biden leads Trump by 12 points among Catholic voters: poll The Hill's Campaign Report: Biden goes on offense MORE won Nevada in 2016, while President Trump won Arizona by fewer than 4 percentage points.

Two GOP senators — Susan Collins Susan Margaret CollinsGraham: GOP will confirm Trump's Supreme Court nominee before the election Gardner signals support for taking up Supreme Court nominee this year Tumultuous court battle upends fight for Senate MORE (Maine) and Lisa Murkowski Lisa Ann MurkowskiGraham: GOP will confirm Trump's Supreme Court nominee before the election Gardner signals support for taking up Supreme Court nominee this year Tumultuous court battle upends fight for Senate MORE (Alaska) — voted against the measure Tuesday, joining with Senate Democrats and independents.

Some GOP senators, including Heller, announced shortly before the vote began that they would support the procedural motion.

Before the vote, the DSCC also launched radio ads targeting Heller and Flake.

The radio ads blasted the two senators and accused them of putting their political interests before those of their constituents.