Also joining the cast in a live-action role is Antonio Banderas, with Michael Sheen in talks to join the production. They will play Rassouli and Mudfly, respectively.

Stephen Gaghan (Traffic, Syriana) will direct from a script that he wrote (an earlier draft was penned by Tom Shepherd). The story is based on the 1920s children’s books by Hugh Lofting.

Joe Roth and Jeff Kirschenbaum (Alice In Wonderland, Snow White and the Huntsman) will produce via their Roth/Kirschenbaum Films, alongside Susan Downey for Team Downey.

Voyage of Doctor Dolittle is set to begin production later this month in London. The pic is dated for a April 12, 2019, release.

Holland is also set to lend his voice to the Blue Sky feature Spies in Disguise, and will reprise his role as Spider-Man in May's Avengers: Infinity War. He is repped by WME, the U.K.'s Curtis Brown and Sloane Offer.

Thompson voice-starred in last year's Beauty and the Beast and is set for BBC and Amazon's King Lear. She is repped by CAA and the U.K.'s Hamilton Hodell.

Fiennes, who voiced Alfred in The Lego Batman Movie, is set to appear alongside Will Ferrell and John C. Reilly in the comedy Holmes & Watson. He is repped by CAA and the U.K.'s Dalzell and Beresford.