The state government has handed new acquisition notices to dozens of homeowners standing in the way of a hospital expansion in Sydney's south-east to overcome “any uncertainty” from a landmark case that cast doubt over its compulsory acquisition powers.

After first issuing notices to homeowners in March, NSW Health's infrastructure arm has sent out new ones for 34 of the 44 properties at Randwick it is yet to snap up for the $720 million Prince of Wales Hospital redevelopment.

This time, it is giving homeowners just 30 days to negotiate before their properties are compulsorily acquired, considerably shorter than the 90 days it gave earlier.

The Herald revealed last week that about 165 acquisition notices handed to land owners for projects such as the hospital redevelopment, a new light rail line, road upgrades and the WestConnex toll road are at risk of becoming invalid or lapsing within weeks.