A major crash involving seven cars and three trucks injured several people and brought traffic to a standstill on the Monash Freeway overnight.

A truck "clipped" another truck travelling towards the city on the freeway near Warrigal Road about 8.40pm on Thursday causing the multi-vehicle smash, a Victoria Police spokeswoman said.

One woman was seriously injured and taken to hospital in a stable condition with a head injury, an Ambulance Victoria spokesman said.