Universal flu vaccine

Pandemic flu is rare but deadly. At least 50 million people died in the 1918 pandemic of H1N1 flu. More recently, about a million people died in the 1957-’58 and 1968 pandemics, while something like half a million died in a 2009 recurrence of H1N1. The recent death tolls are lower in part because the viruses were milder strains. We might not be so lucky next time—a particularly potent strain of the virus could replicate too quickly for any tailor-made vaccine to effectively fight it. A universal flu vaccine that protected not only against the relatively less harmful variants but also against a catastrophic once-in-a-century outbreak is a crucial public health challenge.

Dementia treatment

More than one in 10 Americans over the age of 65 has Alzheimer’s; a third of those over 85 do. As people’s life spans lengthen, the number of people living with the disease—in the US and around the world—is likely to skyrocket. Alzheimer’s remains poorly understood: conclusive diagnoses are possible only after death, and even then, doctors debate the distinction between Alzheimer’s and other forms of dementia. However, advances in neuroscience and genetics are beginning to shed more light. That understanding is providing clues to how it might be possible to slow or even shut down the devastating effects of the condition.

Ocean clean-up

Billions of tiny pieces of plastic—so-called “microplastics”—are now floating throughout the world’s oceans. Much of this waste comes from bags or straws that have been broken up over time. It’s poisoning birds, fish, and humans. Researchers fear that the effects on both human health and the environment will be profound, and it may take centuries to clean up the hundreds of millions of tons of plastic that have accumulated over the decades. Because the pollution is so diffuse, it’s difficult to clean up, and while there are prototype methods for tackling the massive oceanic garbage patches, there is no solution for coasts, seas, and waterways.

Energy-efficient desalination

There is about 50 times as much salt water on earth as there is fresh water. As the world’s population grows and climate change intensifies droughts, the need for fresh water is going to grow more acute. Israel has built the world’s biggest reverse-osmosis desalination facilities and now gets most of its household water from the sea, but that method is too energy intensive to be practical worldwide. New types of membranes might help; electrochemical techniques may also help to make brackish water useful for irrigation. As far as climate-change adaptation technologies go, creating drinking water from the ocean ought to be a top priority.

Safe driverless car

Autonomous vehicles have been tested for millions of miles on public roads. Pilot programs for delivery and taxi services are under way in places like the suburbs of Phoenix. But driverless cars still aren’t ready to take over roads in general. They have trouble handling chaotic traffic, and difficulty with weather conditions like snow and fog. If they can be made reliably safe, they might allow a wholesale reimagining of transportation. Traffic jams might be eliminated, and cities could be transformed as parking lots give way to new developments. Above all, self-driving cars, if widely deployed, are expected to eliminate most of the 1.25 million deaths a year caused by traffic accidents.

Embodied AI

Last fall a video of Atlas, designed by Boston Dynamics, swept the internet. It showed the robot jumping up steps like a commando. This came only two years after AlphaGo beat the world’s best Go player. Atlas can’t play Go (it is embodied, but not intelligent), and AlphaGo can’t run (it’s intelligent, in its own way, but lacks a body). So what happens if you put AlphaGo’s mind in Atlas’s body? Many researchers say true general artificial intelligence might depend on an ability to relate internal computational processes to real things in the physical world, and that an AI would acquire that ability by learning to interact with the physical world as people and animals do.

We can predict hurricanes days and sometimes weeks in advance, but earthquakes still come as a surprise. Predicting them with confidence could save millions of lives.

Earthquake prediction

Over 100,000 people died in the 2010 Haiti earthquake, and the 2004 Indian Ocean tsunami—triggered by one of the most powerful earthquakes ever recorded—killed nearly a quarter of a million people in Indonesia, Sri Lanka, India, and elsewhere. We can predict hurricanes days and sometimes weeks in advance, but earthquakes still come as a surprise. Predicting earthquakes with some confidence over the medium term would allow planners to figure out durable solutions. At least giving a few hours’ warning would allow people to evacuate unsafe areas, and could save millions of lives.