Brock Holt will begin a rehab assignment with Triple-A Pawtucket on Wednesday.

The utility player is scheduled to start at designated hitter and bat second against Columbus.

Manager Alex Cora said Holt likely will take three or four at-bats.

The Red Sox initially placed Holt on the injured list April 6 because of a scratched cornea, which is completely healed. But he was returned from his latest rehab assignment with Pawtucket after experiencing shoulder inflammation.

He was diagnosed with a shoulder impingement.

He appeared in one rehab game for Pawtucket on April 16, but the Red Sox returned him without activating him April 20. He played in one game (April 26) on his second rehab assignment before being returned again.