Since the P365 made its debut, it was an immediate success. The consumer demand for a micro compact pistol with a full-size capacity was extraordinary, and as a result, the P365 quickly became the most popular micro-compact pistol on the market today. The only feature that was consistently requested was that of a manual safety. The P365-MS adds this feature with the same concealability and capacity as the original P365, all while maintaining the pistol's thin profile and ergonomic feel.

The P365-MS is a high-capacity, micro-compact, striker-fired, 9mm pistol featuring a high-capacity, patented modified double-stack magazine for a 10+1 full-size capacity, with 12-round factory made magazines available for 13-round capacity, an ambi-manual safety, ambi-mag catch, and a polymer grip module. The P365-MS comes equipped with X-RAY3 day/night sights and two 10-round magazines.