It’s a known fact that too much salt can increase blood pressure. But new research brings gut bacteria into the mix, and some good news along with it: probiotics may help to reverse the harmful effects of excessive salt. Share on Pinterest New research sheds light on the mechanisms behind hypertension, as well as on new ways to prevent it. An overwhelming proportion of existing studies warn that a high intake of sodium drastically increases your chances of high blood pressure. Here at Medical News Today, we have reported on studies showing that too much salt can double your chances of heart failure, and that even a low intake of salt may still put you at risk of adverse cardiovascular events. But new research adds another key element to this dynamic: gut bacteria. Researchers from the Massachusetts Institute of Technology (MIT) in Cambridge, MA — together with researchers from various institutions in Germany — examined the effect of a high-salt diet on certain healthful gut bacteria. Nicola Wilck, of the Max-Delbruck Center for Molecular Medicine in Berlin, is the first author of the study, and the findings were published in the journal Nature. Dominik Muller, also of the Max-Delbruck Center for Molecular Medicine, and Ralf Linker, of Friedrich-Alexander University in Erlangen, Germany, jointly led the investigation.

Studying salt, gut bacteria, and hypertension Muller and colleagues fed two groups of mice a diet high in sodium and a normal diet, respectively, over a period of 14 days. Up to 4 percent of the former diet consisted of sodium chloride — which is what we have as table salt — while only 0.5 percent of the normal diet consisted of sodium chloride. A fecal analysis revealed that high-sodium mice lacked a beneficial bacterium called Lactobacillus murinus. Additionally, the mice had more of the so-called Th-17 cells, a pro-inflammatory type of “T helper cells.” T helper cells are part of our immune system and they help create a pro- or anti- inflammatory response to a foreign agent in our body. They are called “helper” cells because they help other cells elicit an immune response. Finally, in the experiment described in the study, the rodents that had been fed a diet high in sodium also had high blood pressure, or hypertension. Significantly, when the hypertensive rodents were administered doses of a probiotic containing Lactobacillus bacteria, the pro-inflammatory T helper cells decreased, as did the mice’s blood pressure. To investigate further, the researchers conducted a pilot study in humans, in which they added 6,000 daily milligrams of sodium chloride in the diet of 12 individuals for a period of 2 weeks.