Jaume Collet-Serra, the filmmaker behind The Shallows and Liam Neeson films such as The Commuter and Non-Stop, will direct the project, which is set in the early 20th century and takes place in the Amazon jungle.

Johnson will play a boat captain who takes his sister (Blunt) and her brother (Whitehall) on a mission to find a tree believed to possess healing powers. Wild animals and a competing German expedition figure into the proceedings.

Giamatti will play a crusty harbormaster.

The movie is heading toward a start later this month and will shoot through the summer.

Beau Flynn, John Davis and John Fox are producing, as are Johnson, Dany Garcia and Hiram Garcia. Scott Sheldon is co-producing.

Giamatti currently stars on Showtime’s Wall Street drama Billions, now in its third season, and recently appeared in the Reed Morano-helmed drama I Think We’re Alone Now. He is repped by UTA.