Pablo Escobar’s top hitman, Jhon Jairo Velásquez Vásquez — nicknamed “Popeye” — died Thursday after a battle with esophageal cancer, according to new reports.

Velásquez, 54, died in the early morning hours at the National Cancer Institute in Bogotá, Colombian outlet La FM reported, citing a statement from the country’s National Penitentiary and Prison Institute.

He was hospitalized on New Year’s Eve for esophageal cancer, which metastasized to his stomach, the outlet reported.

Velásquez, who had confessed to killing 300 people, was behind bars in the past — but was recaptured in May 2018 when he continued a life of crime and extortion through the Medellín cartel, according to the report.

Once authorities learned of the seriousness of Velásquez’s illness, he was transferred to Bogotá for palliative care, El Colombiano reported.

Velásquez had an immense criminal record under the orders of multibillionaire drug lord Escobar — dubbed “The King of Cocaine” — who was the founder and leader of the Medellín cartel.

Escobar was shot dead by Colombian security forces in 1993.

Velásquez also had a book, “Surviving Pablo Escobar: ‘Popeye’ The Hitman 23 Years and 3 Months in Prison,” published in 2005, and a YouTube channel, POPEYE_Arrepentido, with more than 1.2 million subscribers.

On his website, he described himself as “another person,” who learned from his life of crime.

“I am repentant and determined to help build the truth for those who lived the reality of the Medellin of the ’80s and ’90s firsthand,” he wrote. “I wake up daily and with the decision to show the scars that make me what I am but do not define what I will be today and tomorrow.”