Four jockeys have been hospitalised and one horse has been euthanased after a shocking fall on Monday afternoon at the Taree Wingham Race Club on the New South Wales Mid North Coast.

Maurice Logue from Racing NSW said during the first race of the afternoon, race horse 'Bazza's Boy' sustained a fracture to his leg when entering the home straight and fell to the ground.

Four jockeys close behind got caught up in the fall and came off their horses.

"Had it happened a little bit later the riders would have peeled out from behind each other so they wouldn't have been bunched,

"It was just one of those unfortunate things," Mr Logue said.

"There wasn't enough time to get around [the horse] or avoid him."

Jockey Samantha Clenton suffered fractures to her collarbone and left leg and was taken to Port Macquarie Base Hospital for treatment.

Fellow jockey Kaylee Kirkwood was taken to the same hospital suffering from a mild concussion and injury to her right leg.

Two jockeys with suspected rib injuries — Jackson Murphy and Nyssa Burrells — were airlifted to Newcastle's John Hunter hospital for treatment.

Mr Logue said Bazza's Boy was euthanased as a result of his injury, while the remaining horses escaped unscathed.

"It was an unfortunate accident, however there will be an investigation which will include an autopsy of Bazza's Boy to determine what happened and to see if there's any action that needs to be taken," he said.

Only hours after the incident, Melbourne Cup champion Michelle Payne was injured during a race in Mildura when she fell from her horse Dutch Courage.