John Stamos is set for a series regular role in the upcoming second season of Fox’s Scream Queens, the comedy-horror series from award-winning executive producers Ryan Murphy, Brad Falchuk and Ian Brennan.

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Stamos’ stint stems from his long-standing relationship with Murphy — Stamos previously recurred on Murphy’s NBC comedy The New Normal and Fox dramedy Glee. I hear top Fox brass helped woo the actor to return to the network following the cancellation of his freshman comedy series Grandfathered, which earned the actor a People’s Choice Award.

For Stamos, the role represents a departure, a foray into darker, sinister territory with a comedic twist. The second season of Scream Queens is set in a hospital, where some of the most fascinating and bizarre medical cases are under observation, Stamos will play Dr. Brock Holt, the hospital’s brilliant, but secretive, head surgeon. This marks Stamos’ return to a hospital setting seven years after the end of his run as Dr. Tony Gates on ER.

Stamos joins returning Scream Queens cast members Jamie Lee Curtis, Emma Roberts, Lea Michele, Abigail Breslin, Keke Palmer, Glen Powell and Niecy Nash who are reprising their roles from Season 1.

Stamos is currently producing and recurring on Fuller House, the spin-off of his hit comedy Full House. Stamos played a key role in getting together the series, which has been drawing big audiences on Netflix. As a producer, Stamos also is in development with Twentieth Century Fox and Academy Award-winning producers Neil Meron and Craig Zadan, on a musical feature set to the songs of the Beach Boys.

Scream Queens hails from Ryan Murphy Television and Brad Falchuk Teley-Vision in association with 20th Century Fox Television. It is is executive-produced by Murphy, Falchuk, Brennan and Alexis Martin Woodall (American Horror Story: Hotel).

Stamos is repped by WME and Brillstein Entertainment.