The DFG-Center for Regenerative Therapies Dresden - Cluster of Excellence at the TU Dresden (CRTD), the Dresden site of the German Center for Neurodegenerative Diseases (DZNE), and the Max Planck Institute for Human Development in Berlin played a pivotal role in the study.

The adult brain continues to grow with the challenges that it faces; its changes are linked to the development of personality and behavior. But what is the link between individual experience and brain structure? Why do identical twins not resemble each other perfectly even when they grew up together? To shed light on these questions, the scientists observed forty genetically identical mice that were kept in an enclosure offering a large variety of activity and exploration options.

"The animals were not only genetically identical, they were also living in the same environment," explains principal investigator Gerd Kempermann, Professor for Genomics of Regeneration, CRTD, and Site Speaker of the DZNE in Dresden. "However, this environment was so rich that each mouse gathered its own individual experiences in it. Over time, the animals therefore increasingly differed in their realm of experience and behavior."

New neurons for individualized brains

Each of the mice was equipped with a special micro-chip emitting electromagnetic signals. This allowed the scientists to construct the mice's movement profiles and to quantify their exploratory behavior. The result: Despite a common environment and identical genes the mice showed highly individualized behavioral patterns. They reacted to their environment differently. In the course of the three-month experiment these differences increased in size.

"Though the animals shared the same life space, they increasingly differed in their activity levels. These differences were associated with differences in the generation of new neurons in the hippocampus, a region of the brain that supports learning and memory," says Kempermann. "Animals that explored the environment to a greater degree also grew more new neurons than animals that were more passive."

Adult neurogenesis, that is, the generation of new neurons in the hippocampus, allows the brain to react to new information flexibly. With this study, the authors show for the first time that personal experiences and ensuing behavior contribute to the „individualization of the brain." The individualization they observed cannot be reduced to differences in environment or genetic makeup.

„Adult neurogenesis also occurs in the hippocampus of humans," says Kempermann. "Hence we assume that we have tracked down a neurobiological foundation for individuality that also applies to humans."

Impulses for discussion across disciplines

„The finding that behavior and experience contribute to differences between individuals has implications for debates in psychology, education science, biology, and medicine," states Prof. Ulman Lindenberger, Director of the Center for Lifespan Psychology at the Max Planck Institute for Human Development (MPIB) in Berlin. "Our findings show that development itself contributes to differences in adult behavior. This is what many have assumed, but now there is direct neurobiological evidence in support of this claim. Our results suggest that experience influences the aging of the human mind."

In the study, a control group of animals housed in a relatively unattractive enclosure was also examined; on average, neurogenesis in these animals was lower than in the experimental mice. „When viewed from educational and psychological perspectives, the results of our experiment suggest that an enriched environment fosters the development of individuality," comments Lindenberger.

Interdisciplinary teamwork

The study is also an example of multidisciplinary cooperation -- it was made possible because neuroscientists, ethologists, computer scientists, and developmental psychologists collaborated closely in designing the experimental set-up and applying new data analysis methods. Biologist Julia Freund from the CRTD Dresden and computer scientist Dr. Andreas Brandmaier from the MPIB in Berlin share first authorship on the article. In addition to the DZNE, CRTD, and the MPIB, the German Research Center for Artificial Intelligence in Saarbrücken and the Institute for Geoinformatics and the Department of Behavioural Biology at the University of Münster were also involved in this project.

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Original publication

„Emergence of Individuality in Genetically Identical Mice", Julia Freund, Andreas M. Brandmaier, Lars Lewejohann, Imke Kirste, Mareike Kritzler, Antonio Krüger, Norbert Sachser, Ulman Lindenberger, Gerd Kempermann, Science, doi: http://www. sciencemag. org/ lookup/ doi/ 10. 1126/ science. 1235294

The Center for Regenerative Therapies Dresden - CRTD at the Technische Universität Dresden was established in 2006 and was able to assert itself in the third round of the German excellence initiative as an excellence cluster and DFG Research Center. It is directed by the developmental and neurobiologist Prof. Dr. Michael Brand. The aim of the CRTD is to study the body's self-healing capabilites and develop completely new regenerative therapies for previously incurable diseases. The Center's research topics focus on haematology and immunology, diabetes, neurodegenerative diseases, and bone replacement. Currently four professors and nine research group leaders work at the CRTD and are integrated in an interdisciplinary network of more than 90 members of seven different institutions in Dresden. The network is additionally supported by 18 corporate partners. Synergies within the network allow a rapid transfer of findings from basic science to clinical applications. Website: http://www. crt-dresden. de

Das Max Planck Institute for Human Development (MPIB) was founded in 1963 in Berlin. As an interdiciplinary research institution, it is devoted to the study of human development and education. The institute belongs to the Max Planck Society for the Advancement of Science, one of the leading organizations for basic research in Europe. Website: http://www. mpib-berlin. mpg. de/ de

The German Center for Neurodegenerative Diseases (DZNE) investigates the causes of diseases of the nervous system and develops strategies for prevention, treatment and care. It is an institution of the Helmholtz Association of German Research Centres with sites in Berlin, Bonn, Dresden, Göttingen, Magdeburg, Munich, Rostock/Greifswald, Tübingen and Witten. The DZNE cooperates closely with universities, their clinics and other research facilities. Co-operation partners in Dresden are the Center for Regenerative Therapies Dresden (CRTD), the Technische Universität Dresden and the Universitätsklinikum Carl Gustav Carus. Website: http://www. dzne. de/ en

Press contact

Prof. Dr. Gerd Kempermann

CRTD Research Group Leader & Site Speaker of DZNE Dresden

Tel.: +49-351/458-82201

E-Mail: gerd.kempermann@dzne.de

Prof. Dr. Ulman Lindenberger

Director of the Center for Lifespan Psychology

Max Planck Institute for Human Development, Berlin

Tel.: +49-30/82406-572

E-Mail: seklindenberger@mpib-berlin.mpg.de

Prof. Dr. Norbert Sachser

Department of Behavioural Biology

University of Münster

Tel.: +49-251/83-23884

E-Mail: sachser@uni-muenster.de

Birte Urban-Eicheler

Press and Public Relations

CRTD, Dresden

Tel.: +49-351/458-82065

E-Mail: birte.urban@crt-dresden.de

Dr. Dirk Förger

Head of Press and Public Relations

DZNE, Bonn

Tel.: +49-228/43302-260

E-Mail: dirk.foerger@dzne.de

Dr. Britta Grigull

Head of Press and Public Relations

Max Planck Institute for Human Development, Berlin

Tel.: +49-30/824 06-211

E-Mail: grigull@mpib-berlin.mpg.de