Vice President Pence on Friday called on Republicans in the Senate to vote for current legislation meant to overturn ObamaCare, after a high profile defection by Sen. John McCain John Sidney McCainMomentum growing among Republicans for Supreme Court vote before Election Day McConnell urges GOP senators to 'keep your powder dry' on Supreme Court vacancy McSally says current Senate should vote on Trump nominee MORE (R-Ariz.) announced minutes before the speech left the bill's fate hanging by a thread.

"A vote against Graham-Cassidy is a vote to save ObamaCare," Pence told a crowd in Anderson, Ind., speaking of the legislation co-sponsored by GOP Sens. Lindsey Graham Lindsey Olin GrahamMcConnell locks down key GOP votes in Supreme Court fight Will Republicans' rank hypocrisy hinder their rush to replace Ginsburg? Momentum growing among Republicans for Supreme Court vote before Election Day MORE (S.C.) and Bill Cassidy William (Bill) Morgan CassidyCoushatta tribe begins long road to recovery after Hurricane Laura Senators offer disaster tax relief bill Bottom line MORE (La.).

“It’s time for every member of the Republican majority to keep their word to the American people,” he said, without specifically calling out McCain for his opposition.

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The bill is one of the GOP's last ditch attempts to repeal and replace ObamaCare, a promise multiple Republicans ran on in the last election where they won the majority in the House and Senate.

"The Republican majority in Congress in particular was not elected to save ObamaCare, they were elected to repeal and replace it," Pence said.

Congress has until Sept. 30 to pass the bill using a special budget procedure called reconciliation, which would require 50 votes plus a tie-breaker from Pence to pass the Senate.

McCain's Friday announcement that he would opposed the bill, along with Kentucky Sen. Rand Paul Randal (Rand) Howard PaulSecond GOP senator to quarantine after exposure to coronavirus GOP senator to quarantine after coronavirus exposure The Hill's Morning Report - Sponsored by National Industries for the Blind - Trump seeks to flip 'Rage' narrative; Dems block COVID-19 bill MORE's previously announced opposition, left the bill on a razor's edge. Republicans cannot lose any more votes on the measure.

Pence called out "opposition" to the bill in a tweet that doubled down on the Trump administration's determination to pass the legislation.

The opposition is forming up. Some have gone so far as to announce opposition already. But @POTUS & I are undeterred #VPinIN — Vice President Pence (@VP) September 22, 2017

Several Republican senators are wary of the bill, such as Alaska Sen. Lisa Murkowski Lisa Ann MurkowskiMcConnell locks down key GOP votes in Supreme Court fight Most Americans think winner of election should pick next Supreme Court justice: poll Murkowski: Supreme Court nominee should not be taken up before election MORE, and could put the final nail in the coffin should they decide to vote "no."

“I cannot in good conscience vote for the Graham-Cassidy proposal. I believe we could do better working together, Republicans and Democrats, and have not yet really tried," McCain said in a statement Friday.

Pence also addressed tax reform in his speech and called on Democratic Sen. Joe Donnelly Joseph (Joe) Simon DonnellyNames to watch as Trump picks Ginsburg replacement on Supreme Court Momentum growing among Republicans for Supreme Court vote before Election Day Barrett seen as a front-runner for Trump Supreme Court pick MORE, the incumbent from Indiana, to support tax reform efforts.

"Joe, let's decide today we're gonna get this tax cut done, and we're gonna get it done together," Pence said.

Donnelly, who joined Pence on stage at the event, is one of a number of vulnerable Democratic senators, such as Sens. Joe Manchin Joseph (Joe) ManchinNames to watch as Trump picks Ginsburg replacement on Supreme Court Momentum growing among Republicans for Supreme Court vote before Election Day Gardner on court vacancy: Country needs to mourn Ginsburg 'before the politics begin' MORE (W.Va.) and Heidi Heitkamp Mary (Heidi) Kathryn HeitkampCentrists, progressives rally around Harris pick for VP 70 former senators propose bipartisan caucus for incumbents Susan Collins set to play pivotal role in impeachment drama MORE (N.D.), the White House is trying to woo to support the tax reform effort.