Altria reported a $4.1 billion write-down on its Juul Labs investment on Thursday, another sizable charge as the vaping crisis continues to roil the e-cigarette industry.

The company now values its 35 percent stake in the e-cigarette company at $4.2 billion, a significant drop from the $12.8 billion it paid in December 2018. Three months ago, Altria, one of the world’s largest tobacco sellers, devalued its investment in Juul by $4.5 billion.

Altria, the maker of Marlboro cigarettes, said its fourth-quarter charge was largely due to the growing number of legal cases pending against Juul, which had increased more than 80 percent since the end of October.

Howard Willard, chief executive of Altria, said that despite “the unexpected challenges” Juul faced, the company had made progress in its noncombustible platform with the IQOS e-cigarette and on nicotine pouches.