The nation’s top immigration official said Friday that Mayor Bill de Blasio needs to “own” the death of a 92-year-old Queens woman allegedly killed as a result of his “sanctuary city” policy.

“The policies of the mayor make this city less safe,” said acting Immigration and Customs Enforcement Director Matthew Albence.

“If you’re going to have a sanctuary city policy, just own it.”

During a news conference in Lower Manhattan, Albence grew visibly angry while discussing the case of Maria Fuertes, who was sexually abused and murdered while walking near her home on Jan. 6.

The suspect, illegal immigrant Reeaz Khan, had previously been released without bail in an assault on his dad despite a federal request that he be held for deportation proceedings, ICE has said.

“We wanted him three months ago before he did this,” Albence said. “If we had been able to cooperate with the NYPD, Maria Fuentes would be alive today.”

Albence added bitterly, “Too little, too late, New York City.”

The ICE chief, who was flanked by members of the NYPD’s Sergeants Benevolent Association, said the city last year complied with just 10 of more than 7,500 detainer requests for illegal immigrants charged with or convicted of various crimes.

The cases involved more than 200 homicides, 500 robberies, 1,000 sexual offenses, 1,000 weapons offenses and 3,500 assaults, he said.

“ICE has no option but to increase enforcement” because of the city’s “lack of cooperation,” Albence said.

Under de Blasio’s sanctuary policy, illegal immigrants are turned over to ICE only if they’ve been convicted of any of 170 “serious or violent felonies.”

In response to Albence’s remarks, mayoral spokeswoman Freddi Goldstein tweeted, “The death of Maria Fuertes was an absolute tragedy and we mourn for her.”

“Fear, hate & attempts to divide are signatures of the Trump Admin, not NYC. We are the safest big city in America b/c of our policies, not in spite of them. We must band together as NYers & reject these lies,” she added.