Overview

The A/J strain is an inbred albino strain of mouse model. It is very frequently used in cancer research, on account of its strong tendency to develop tumors when presented with common carcinogens. It is one of the most popular strains used in mouse experiments.[1][2]

History

The A/J strain is originally derived from the A strain and is related to the BALB/c strain. The A strain was developed in 1921, from a cross between two albino stocks, by L. C. Strong. Stock from this strain came to the Jackson Laboratory in 1947, where the A/J strain was created.[1][2]

A/J mice have proved highly popular in immunological and cancer research, although their popularity may have decreased in recent years.[2]

Physical Characteristics

Mice of the A/J strain are albino, and so have completely white fur. Their brain, kidneys, and thymus are all small relative to their overall body weight.[1][2]