Hong Kong (CNN) The World Health Organization has declared the novel coronavirus outbreak a public health emergency of international concern, after an emergency meeting on Thursday.

The decision came after cases of human-to-human transmissions were confirmed outside China, where the outbreak started. A first such case was confirmed in the United States on Thursday, following a case in Germany earlier this week.

The number of cases of the virus, which has killed at least 213 people, shot up to more than 8,100 in mainland China alone by Thursday evening. That is a higher number of infected people than the number who caught SARS worldwide during the 2002-2003 epidemic. However, the current case fatality rate for Wuhan virus is around 2% -- significantly smaller than SARS' 9.6% mortality rate

While the virus originated in the Chinese city of Wuhan in December, there are now more than 100 cases in 20 other countries and territories spanning Asia, North America, Europe and the Middle East. India and the Philippines were the latest to confirm the virus had reached their shores.

Thousands of people were held on a cruise ship in Italy on Thursday and Russia closed off its borders with China as global fears continued to grow over the rapidly spreading Wuhan coronavirus

The Costa Smeralda docked in the Civitavecchia port near Rome on Thursday.

On Thursday, 7,000 people, including 1,000 crew, were confined to a cruise ship in a port near Rome as a couple was being tested for the virus. A spokesperson for Costa Cruises told CNN that a 54-year-old woman aboard the cruise ship was suffering from a fever and that she and her husband were both being tested. Italian news agency ANSA and public broadcaster RAI reported that the woman and her husband were from Hong Kong and were being kept separately in solitary confinement in the hospital section of the cruiseliner.

The Costa Smeralda cruise ship is now docked at Civitavecchia port, a coastal town northwest of Rome. It had arrived from Palma de Majorca, Spain, as part of its tour of the western Mediterranean.

The test came back negative, the Italian Ministry of Health said Thursday night, but it was unclear when the passengers will be allowed to disembark.

Border closures

Several countries are repatriating their citizens from China and multiple air carriers have suspended flights to the country.

Russian state media reported Thursday that Prime Minister Mikhail Mishustin had signed an order to close Russia's border with China in the Far East in an effort to prevent the spread of the virus.

"An order has been signed today, it is in the works. Today we will inform everyone accordingly about the relevant measures to close the border in the Far Eastern region and other measures that have been taken by the government," Mishustin said, RIA reports.

Russia's Far Eastern Federal District shares a land border with China, Mongolia and North Korea. Thursday's announcement comes after several Russian tour operators and charter flight companies suspended flights to China.

Russia will also limit its railway service with China from Friday, TASS reported.

In the semi-autonomous city of Hong Kong, where only 10 cases have been confirmed, the government has closed a high-speed rail station that would usually connect the city to China's mainland. Hong Kong has introduced new limits it says will cut the amount of mainland Chinese travelers coming to the city by 80%.

A CNN correspondent described Hong Kong as a ghost town, with empty shops and streets at a time that Chinese New Year celebrations usually light up the city. Instead, people lined up for more than three hours to collect surgical face masks to help keep them safe from the virus.

Several countries, including the United States, Japan and some in the European Union, are evacuating their citizens from Wuhan . The United Kingdom was given the green light to fly nationals home in the early hours of Friday morning after a long delay.

Multiple major air carriers are also canceling flights to and from parts of China, including British Airways, American Airlines, Air Canada, KLM, Lufthansa and United. The moves follow travel guidance from multiple governments advising against "nonessential" travel to the country.

Across Asia and elsewhere, strict checks and screening have been put in place for all travelers arriving from China -- though this may be ineffective as scientists previously warned that the virus can be spread while patients are asymptomatic.

Quarantine city

As the number of confirmed cases of the Wuhan coronavirus continues to grow worldwide, the city at the heart of the outbreak marks a week since it was first placed under lockdown

All 31 provinces and regions within China have now reported cases of the virus, including Tibet, which had instituted strict checks on travelers and shutdown tourist sites in an ultimately unsuccessful attempt to stop its spread to the region.

Some 60 million people across Hubei, the province of which Wuhan is the capital, are on some level of lockdown, and many travelers from the region have been ordered to self-quarantine, holed up in their apartments or hotel rooms for days on end.

In Wuhan itself, 11 million people are marking a week on lockdown with no sign of immediate relief. Nor is there firm evidence that their sacrifice has been worth it, with the virus spreading around the country and scientists warning that other major cities could soon become self-sustaining epidemics.

Online, people trapped in their houses have been uploading videos and photos showing various ways they are staying busy -- staging makeshift Lunar New Year lion dances in their apartments, exercising, and urging others to keep their spirits up. But as the lockdown stretches on, such positivity may be harder to come by, particularly as some begin to feel the lost wages or business.

Chinese President Xi Jinping on Wednesday ordered the People's Liberation Army to aid in "winning the battle against the novel coronavirus epidemic." Military medical teams have already been sent to Wuhan and soldiers are also aiding with transporting supplies to the stricken city.

Outside of Hubei, infections are predicted to continue growing for weeks, if not months. Researchers at Imperial College London have estimated that at least 4,000 people were infected in Wuhan by January 18, almost a week before the lockdown began. Their model suggests a low national figure of 20,000 infections by the end of the month, potentially as high as 100,000.

Speaking to state media Tuesday , Zhong Nanshan, one of China's leading respiratory experts and a hero of the 2003 fight against SARS, said he expected the peak to come in up to 10 days.

"It is very difficult to definitely estimate when the outbreak reaches its peak. But I think in one week or about 10 days, it will reach the climax and then there will be no large-scale increases," Zhong said.