Michigan State University was propelled on Thursday to the center of the sexual abuse scandal involving Dr. Lawrence G. Nassar, as state and federal agencies mounted investigations demanding to know what the college knew of his behavior and when.

Neither the sentencing of Dr. Nassar on Wednesday to 40 to 175 years in prison, nor the resignation of the university president a few hours later, quelled the furor. Education Secretary Betsy DeVos said on Thursday that her department would investigate Michigan State’s role, while state legislators asked that the university provide unredacted records of its investigations of Dr. Nassar and threatened to issue subpoenas if the school did not swiftly comply.

At the same time, the state attorney general was preparing his own review of the university, a United States senator asked for congressional hearings, and the speaker of the Michigan House called for the resignations of the university’s trustees, who are elected by voters.

“This is one of the biggest scandals in the history of our state,” said the speaker, Tom Leonard, a Republican, who has asked House lawyers to review options for removing trustees if they did not quit. “We are dealing with a Big Ten university. We are dealing with a monster who was a serial child molester and rapist who may have violated more victims than any other rapist in the history of our state.”