A woman is fighting for her life after her car and a tram collided on Royal Parade in Parkville on Tuesday.

Police and paramedics were called to the scene, near the intersection of Gatehouse Street at about 12.30pm and discovered the car alight, an Ambulance Victoria spokesman said.

The crash on Royal Parade has left a woman fighting for her life. Credit:Paul Jeffers

The driver of the car, a 68-year-old man from East Keilor, and his 66-year-old wife were both injured.

Traffic delays are expected through peak hour as investigators remain on the scene.