Tiny oxygen generators boost effectiveness of anticancer treatment

Researchers have created and tested a miniature device, seen here, that can be implanted in tumors to generate oxygen, boosting the killing power of radiation and chemotherapy. The technology is designed to treat solid tumors that are hypoxic at the center, meaning the core contains low oxygen levels. The device (right) fits inside a tube (left) that can then be inserted into a tumor with a biopsy needle. (Birck Nanotechnology Center, Purdue University) Download image

WEST LAFAYETTE, Ind. - Researchers have created and tested miniature devices that are implanted in tumors to generate oxygen, boosting the killing power of radiation and chemotherapy.

The technology is designed to treat solid tumors that are hypoxic at the center, meaning the core contains low oxygen levels.

"This is not good because radiation therapy needs oxygen to be effective," said Babak Ziaie, a Purdue University professor of electrical and computer engineering and biomedical engineering. "So the hypoxic areas are hard to kill. Pancreatic and cervical cancers are notoriously hypoxic. If you generate oxygen you can increase the effectiveness of radiation therapy and also chemotherapy."

The new "implantable micro oxygen generator" is an electronic device that receives ultrasound signals and uses the energy to generate a small voltage to separate oxygen and hydrogen from water – a chemical operation called water electrolysis.

"We are putting these devices inside tumors and then exposing the tumors to ultrasound," Ziaie said. "The ultrasound energy powers the device, generating oxygen.

The devices were created at the Birck Nanotechnology Center in the university's Discovery Park. Purdue researchers are working with Song-Chu (Arthur) Ko, an assistant professor of clinical radiation oncology at the Indiana University School of Medicine.

Researchers have tested the devices in pancreatic tumors implanted in mice, showing they generated oxygen and shrunk tumors faster than tumors without the devices. The devices are slightly less than one centimeter long and are inserted into tumors with a hypodermic biopsy needle.

This diagram shows the design of a miniature device that can be implanted in tumors to generate oxygen, boosting the killing power of radiation and chemotherapy. (Birck Nanotechnology Center, Purdue University) Download image

"Most of us have been touched by cancer in one way or another," Ziaie said. "My father is a cancer survivor, and he went through many rounds of very painful chemotherapy. This is a new technology that has the potential to improve the effectiveness of such therapy."

Findings are detailed in a research paper appearing online this month in Transactions on Biomedical Engineering. The paper was written by research assistant professor Teimour Maleki, doctoral students Ning Cao and Seung Hyun Song, Ko and Ziaie.

"The implantable mini oxygen generator project is one of 11 projects the Alfred Mann Institute for Biomedical Development at Purdue University (AMIPurdue) has sponsored," Ziaie said. "AMIPurdue has been instrumental in providing the development funding of roughly $500,000 on this project. And beyond funding, the AMIPurdue team has also helped us with market research, physician feedback, industry input, as well as intellectual property and regulatory strategy. We have been able to accomplish a great deal in a short time due to the collaborative effort with AMIPurdue."

A patent application has been filed for the design.

Future work may focus on redesigning the device to make it more practical for manufacturing and clinical trials.

Writer: Emil Venere, 765-494-4709, venere@purdue.edu

Source: Babak Ziaie, 765-494-0725, bziaie@purdue.edu

Note to Journalists : An electronic copy of the research paper is available from Emil Venere, 765-494-4709, venere@purdue.edu