Setup WiFi.

Left mouse click over the WiFi icon on the top bar. Choose your network to connect. You only need to do once unless the network setting has changed or need to be changed.

Setup Default Audio

This step is important to get the Raspberry Pi Zero Docking Hub audio to work with the default Alexa software.

Start a terminal and edit /boot/config.txt

sudo nano /boot/config.txt

Disable the analog and hdmi audio by inserting '#' in front of the following line in the file:

#dtparam=audio=on

Press ctrl-x, y, and enter to save.

In the same terminal, edit ~/.asoundrc

nano ~/.asoundrc

Replace the content of that file with the following:

pcm.!default { type plug slave { pcm "hw:1,0" } } ctl.!default { type plug card 1 }

Press ctrl-x, y, and enter to save.

Unfortunately, I have yet to find a permanent way to set the default. In the meantime, you need to do it at every startup.

Enable SSH/VNC (Optional)

If you don't want to use the monitor, keyboard, and mouse at next startup, enabling these options would allow you to remote access the Pi. These options are under Preference/Raspberry Pi Configuration, then go to Interfaces and checkmark the SSH and VNC options.