The Speaker of the New South Wales Parliament has launched an extraordinary attack on the Labor Opposition, accusing them of being drunk in Question Time.

Shelley Hancock — the Liberal MP for the South Coast — made the claim after booting several Labor MPs from the chamber, calling them "blockheads", "boofheads" and "idiots", during the final parliamentary sitting before the mid-winter break.

The Opposition accused her of being biased and not fit for office, but Ms Hancock has now escalated the feud by suggesting the Opposition benches' behaviour was fuelled by alcohol.

"I am really concerned about the effect of alcohol on many members," Ms Hancock told the ABC.

"I suspect, and many people have said to me, that they're smelling alcohol on members when they come into question time.

"There is just absolutely no respect for the Speaker.

"If people want to be thrown out because of their unruly behaviour then they should be, and last Thursday they were disgraceful."

Manager of Opposition business Michael Daley said he was gobsmacked by the Speaker's attack and denied members of the Opposition were drunk.

"It's just rubbish," Mr Daley said.

"The Speaker should have a look at her own performance because she's getting a reputation for being the worst speaker in the nation — worse than Bronwyn Bishop."

Mr Daley said that Ms Hancock had ejected Labor MPs from the chamber 263 times since 2015 and was desperately trying to justify her own behaviour.

"She's just concocted this sad desperate defence … but any objective observation of question time will see that Shelley Hancock uses her position as speaker inappropriately."

He said Ms Hancock should consider whether she should return to the Speaker's chair after the winter break.