Police are seeking urgent public assistance to help find a five-year-old girl reported missing at Nerang on the Gold Coast who "may be at significant risk".

Approximately 120 police and State Emergency Service personnel are involved in the search.

The girl, who suffers from a medical condition, ran away from home around 4:30pm on Sunday.

Police are searching in and around Nielsens Road, near the motorway overpass, and later issued an Amber Alert, urging anyone with information on the girl's whereabouts to contact them.

The girl is described as Caucasian with blonde shoulder-length hair and blue eyes.

She was wearing a dark pink t-shirt with a lady bird emblem on the front and dark blue denim shorts.