LOS ANGELES — Since 2011, when “Bridesmaids” became a global hit and expanded the range of female-driven comedy, Hollywood has been desperate for its screenwriters, Kristen Wiig and Annie Mumolo, to team again on another big movie.

They have finally agreed: Ms. Wiig and Ms. Mumolo will write, produce and star in a wide-release comedy for TriStar Productions, which described the film as the story of “best friends who find themselves in over their heads and out of their depths, which were, perhaps, not too deep to begin with.” The plot involves a town called Vista Del Mar.

Ms. Wiig is also expected to direct, a first for her. A release date has not been set.

“We’re very excited to be writing,” the two women said in a statement. “We will be going into a cave for months to finish. An actual cave. We found one that’s nice and big. We’re putting a couch in there.”

Ms Wiig added: “I’ve been wanting to direct for some time now. This seems like the perfect first project.”