Ellis and Silk accused these theorists of “moving the goalposts” of science and blurring the line between physics and pseudoscience. “The imprimatur of science should be awarded only to a theory that is testable,” Ellis and Silk wrote, thereby disqualifying most of the leading theories of the past 40 years. “Only then can we defend science from attack.”

They were reacting, in part, to the controversial ideas of Richard Dawid, an Austrian philosopher whose 2013 book String Theory and the Scientific Method identified three kinds of “non-empirical” evidence that Dawid says can help build trust in scientific theories without empirical data. Dawid, a researcher at LMU Munich, answered Ellis and Silk’s battle cry and assembled far-flung scholars anchoring all sides of the argument for the high-profile event.

Gross, a supporter of string theory who won the 2004 Nobel Prize in physics for his work on the force that glues atoms together, kicked off the workshop by asserting that the problem lies not with physicists but with a “fact of nature”—one that we have been approaching inevitably for four centuries.

The dogged pursuit of a fundamental theory governing all forces of nature requires physicists to inspect the universe more and more closely—to examine, for instance, the atoms within matter, the protons and neutrons within those atoms, and the quarks within those protons and neutrons. But this zooming in demands evermore energy, and the difficulty and cost of building new machines increases exponentially relative to the energy requirement, Gross said. “It hasn’t been a problem so much for the last 400 years, where we’ve gone from centimeters to millionths of a millionth of a millionth of a centimeter”—the current resolving power of the Large Hadron Collider (LHC) in Switzerland, he said. “We’ve gone very far, but this energy-squared is killing us.”

As we approach the practical limits of our ability to probe nature’s underlying principles, the minds of theorists have wandered far beyond the tiniest observable distances and highest possible energies. Strong clues indicate that the truly fundamental constituents of the universe lie at a distance scale 10 million billion times smaller than the resolving power of the LHC. This is the domain of nature that string theory, a candidate “theory of everything,” attempts to describe. But it’s a domain that no one has the faintest idea how to access.

The problem also hampers physicists’ quest to understand the universe on a cosmic scale: No telescope will ever manage to peer past our universe’s cosmic horizon and glimpse the other universes posited by the multiverse hypothesis. Yet modern theories of cosmology lead logically to the possibility that our universe is just one of many.

Whether the fault lies with theorists for getting carried away, or with nature, for burying its best secrets, the conclusion is the same: Theory has detached itself from experiment. The objects of theoretical speculation are now too far away, too small, too energetic or too far in the past to reach or rule out with our earthly instruments. So, what is to be done? As Ellis and Silk wrote, “Physicists, philosophers and other scientists should hammer out a new narrative for the scientific method that can deal with the scope of modern physics.”