Rex Ryan

Buffalo Bills coach Rex Ryan walks on the sideline during the second half of the team's NFL football game against the New York Jets on Thursday, Sept. 15, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)

(Associated Press)

Following a Week 3 victory over the Arizona Cardinals, the Buffalo Bills will enter Gillette Stadium to take on the New England Patriots.

Tom Brady will be out as he serves the final game of his suspension, and the status of backup quarterbacks Jimmy Garoppolo and Jacoby Brissett are up in the air due to injuries. Buffalo has a chance to give New England its first loss of the season, but ESPN's Michael Wilbon doesn't see that happening.

On Monday's episode of "Pardon the Interruption," Tony Kornheiser asked Wilbon if the Patriots should be worried about the Bills. Wilbon quickly shot the idea down quickly and said that Buffalo will be the latest team to get run over by the Patriots.

"They're going to wipe the floor with Rex Ryan and the Bills," said Wilbon. "Rex Ryan, (on Sunday), they were great. They were terrific. I thought the Bills would beat Arizona, which is completely overrated. Carson Palmer had about as bad a day as you could have. But the Patriots are going to wipe the floor with the Bills."

The Bills have only one victory at Gillette Stadium, so Wilbon's prediction may not be too far off.