In the place of shows like “All In,” Griffin and Lack may consider experimenting with more nonideological programming, sources there said. “8 o’clock is a done deal. That’s going to change,” one high-level NBCUniversal source said. “There is going to be a change at 8 o’clock, and it’s not going to be a liberal. It’s going to be a nonideological, down-the-middle program.”

Maddow, the network’s marquee attraction, will continue to anchor at either 8 p.m. or 9 p.m., sources said. Chris Matthews, the NBC stalwart who has hosted “Hardball” since 1999, is also likely to stay. He is seen as an immense asset in presidential campaign seasons, and his program has seen impressive ratings gains since consolidating to one hour (it previously aired at both 5 p.m. and 7 p.m.). Several sources said Lawrence O’Donnell, who wraps up the prime-time schedule at 10, is also likely to ride out the current transition.

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Dayside will go through its own changes. And in a strange twist of fate, the model show for the liberal network’s future may be the one hosted by a conservative.

Despite its own ratings setbacks, “Morning Joe,” the three-hour morning talk show anchored by former Republican congressman Joe Scarborough and Mika Brzezinski, is among the network’s most influential — and lucrative — programs. MSNBC made around $300 million last year, sources with knowledge of the financials said, and while it’s impossible to know how much of that is attributable to “Morning Joe,” sources described the program as a “cash cow.” (Nearly half of MSNBC’s income comes from subscriber fees, and that percentage is set to go up significantly when MSNBC increases its rate this year.)

The success of “Morning Joe” depends more on the quality than the quantity of its viewers. The show typically draws a better-educated, wealthier and more influential audience than any other morning show on television. At its best — when the bookings are big and the conversation is focused — it has the power to set the daily agenda in politics, media and publishing. The problem, as many NBCUniversal sources rush to point out, is that, since 2012, the show has often lacked focus. However, one source close to the show said Scarborough has become “re-engaged” in the run-up to the 2016 presidential race. Spread across MSNBC daytime, the “Morning Joe” model would mean more shows that blend news, analysis and informal banter, anchored by prominent personalities and boosted by big political bookings. (POLITICO reporters and editors are frequent guests on “Morning Joe” and other MSNBC programs.)

However the programming lineup shakes out, the biggest challenge for MSNBC could be learning how to cope with an unrivaled Hillary Clinton candidacy. MSNBC rose to prominence on the coattails of a historic Democratic presidential candidate. But the current presumptive nominee has offered far less to be enthusiastic about.

“Hillary is not the ideal candidate for MSNBC to ride,” one television industry executive said. “A coronation without any real race is not good for them either.”

Indeed, after Clinton’s news conference about her private emails, the usually forgiving afternoon hosts at “The Cycle” hosted a very critical conversation about the former secretary of state’s poor handling of the so-called scandal. Gone was the enthusiasm of the “hope and change” era, gone was the promise of an uplifting campaign that could usher in a new era of progressivism.

Gone, too, were the viewers.

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