I have now had the privilege to treat over 500 autistic kids with medical cannabis in Israel. This report is meant to support this treatment by documenting a more extensive experience than the original 100 cases I reported on a year and a half ago.

The results continue to be rather consistent. As I reported earlier, about 60% of children respond well to an oil that is 20:1:: CBD:THC. Another 15-20% need a higher proportion of THC, often more THC than CBD. The last 20% or so remain somewhat enigmatic; at times a change of strains makes a big difference, sometimes we admit have to admit treatment failure.

I try to make the treatment as systematic as possible, despite our ignorance regarding more of the compounds in the cannabis plants we use. I try to get an optimal effect of the appropriate oil (60% of the time the CBD rich oil, 20% of the time the THC rich oil) in the morning dose by increasing by a drop every few days until increase yields no improvement. Then I try to “fine tune” the CBD:THC ration with the other oil in the same way until optimal effect is reached. Then I see how long the dose lasts and add one or more additional doses during the day until a good result over the entire day and good sleep is achieved. This trial and error takes about a month.

My experience suggests that this systematic approach creates the most reliable results. There are others whose experience leads them to “guess” when to add the THC oil to the CBD oil, or when to add additional doses, but I find when I reevaluate the treatments at the annual license renewal that oftentimes a less than optimal result has been achieved. There is no data-based way to study this.

When the first approach is not effective, I then systematically attempt to try other strains and about half the time this yields good results. Therefore at least 10% of the children in my experience require access to a variety of full strains in order to achieve treatment goals. I can state unequivocally that I have personally witness children who respond entirely differently to different strains whose CBD:THC ratio is identical.

Excellent results are attained along the full range of the autistic spectrum. Most studies for some reason favor looking at low-function children with violent outbursts. My experience show that high-functioning children respond extremely well, with an increased sharpness in their listening, presence, precision of language and more appropriate responses to humor. They feel much better as human beings and more secure in social settings. Many of these children are able to recognize the improvement as an improved connectivity between resting and executive brain states that I had suggested in an earlier communication. I have treated several dozen very young children, less than 4 years of age, with results as encouraging as those for the older children.

I have seen almost no side effects to this treatment. Some rare children (about 3-4 out of 500) whose sphincter control was borderline lost control (3 of bladder, one of both bladder and rectum) temporarily. The regression was reversed when the particular oil was discontinued. No one became addicted and there were absolutely no outbreaks of anything like psychosis due to cannabis treatment.

It is very impressive to see just how many children are able to discontinue other psychotropic medication once they stabilize on cannabis. I would estimate about three-quarters of children on medications are able to discontinue and feel better for doing such.

Two areas remain less clear. One is the exacerbation of seemingly obsessional behaviors that comes together with improvement of other areas such as explosive expressions of frustration. My preliminary view is that this is likely to be temporary and be a result of heightened presence and awareness. AT times I have added St. John’s Wort with occasional success. This is an area for more study.

The second area is that of attention. In Israel many overactive autistic children are given the additional diagnosis of ADHD, something I feel to be rather unscientific. In my experience 80-90% of the treatments with stimulants are either unsuccessful or deleterious. However, the results of cannabis ion attention are less reliable than in other areas. I would estimate that perhaps half of the children become more attentive. This issue may involve the way the school setting interacts with the cannabis treatments. It is another are for more systematic study.

This very form of this communication documents the need for differential research in this field. So far published reports do not distinguish characteristics of the children, and correlation with doses and strains. This is an obvious desideratum. I am grateful to TOI for the use of this blog to communicate with the community of families and physicians who are nearly starved for information and can get little guidance from published studies to date.

I would like to propose a series of First Principles for Clinical Practice based on my experience: