Giants cornerback Janoris Jenkins almost never leaves the field when healthy. He played the first 76 defensive snaps in Sunday's 27-22 loss to the Chargers before missing the final two snaps. That absence could be a bad omen.

The Chargers got the ball back with 40 seconds left after a tipped Eli Manning pass was intercepted at midfield. While the rest of the Giants' defensive starters took the field for the final kneel downs by Chargers quarterback Philip Rivers, Jenkins headed to the locker room.

Jenkins' early departure may have gone unnoticed if coach Ben McAdoo hadn't used the Giants' final timeout with 38 seconds remaining after Rivers' first kneel down. While the timeout by McAdoo was an act of desperation, he was still clearly hoping for a fumbled snap to give his team a shot at a miraculous win. Meanwhile, his All-Pro cornerback had already given up.

"We'll handle all those issues in-house," McAdoo said during Monday's teleconference.

When asked if it was safe to say he didn't appreciate Jenkins' premature exit, McAdoo didn't respond. Jenkins left the locker room before it was open to the media and defensive coordinator Steve Spagnuolo was spotted chasing after the cornerback.

Losing the locker room has to be McAdoo's biggest concern after the Giants' shocking 0-5 start. Jenkins' early exit looks like one of the first cracks in the foundation.

Here are some additional takeaways from Sunday's snap counts:

*Cornerback Eli Apple wasn't happy with his benching for the first three series. Apple's benching on defense led to an increase in special teams work, as the 2016 first-round pick played 15 snaps in the kicking game. That was the most special teams snaps of Apple's 19-game career.

*Defensive end Jason Pierre-Paul played 71-of-78 defensive snaps after being listed as questionable with shoulder and knee injuries. Pierre-Paul has played 93.5 percent of the defensive snaps this season. While he didn't have a sack on Sunday, Pierre-Paul had one quarterback hit and six hurries, according to Pro Football Focus.

*Kerry Wynn started and played 44 snaps in place of defensive end Olivier Vernon, who missed the first game of his six-year career with an ankle injury. Fifth-round pick Avery Moss made his career debut on defense and played 29 snaps. Romeo Okwara, who entered the season as the No. 3 defensive end, played just 13 snaps.

*There was no rotation at free safety a week after Darian Thompson shared snaps with backup Andrew Adams. Thompson played 75 snaps, while Adams played just two snaps and Nat Berhe logged six snaps. Thompson responded with the best game of his young career, recording a team-high 11 tackles and an interception in the end zone in the third quarter.

*Strong safety Landon Collins missed three defensive snaps while dealing with a sprained ankle. Collins had played every defensive snap in the previous 18 games. He has only missed eight defensive snaps since the start of last season.

*Linebacker Jonathan Casillas, who had played 89 percent of the defensive snaps in the first four games, played just 35 snaps. Casillas' snaps mostly went to Keenan Robinson, who played 59 snaps.

*Tight end Rhett Ellison (50 snaps) and wide receiver Roger Lewis (45) got their most action of the season due to the injuries that decimated the Giants' wide receiver corps. The Giants only had four healthy receivers at the end of the game: Lewis, Ellison and tight ends Evan Engram and Jerell Adams.

*D.J. Fluker played the final 58 snaps at right guard after replacing John Jerry on the third series of the game.

*Odell Beckham Jr. played two special teams snaps before suffering a season-ending ankle injury on offense late in the game. Beckham allowed a punt to go into the end zone for a touchback early in the fourth quarter and he had a 20-yard kickoff return late in the game.

Offensive snap count totals (out of 70):

QB Eli Manning: 70

OL Ereck Flowers: 70

OL Justin Pugh: 70

OL Brett Jones: 70

OL Bobby Hart: 70

OL D.J. Fluker: 58

TE Evan Engram: 57

WR Odell Beckham Jr.: 55

TE Rhett Ellison: 50

WR Roger Lewis: 45

RB Wayne Gallman: 27

WR Brandon Marshall: 27

WR Sterling Shepard: 24

RB Shane Vereen: 23

RB Orleans Darkwa: 20

TE Jerell Adams: 14

OL John Jerry: 12

WR Dwayne Harris: 8

Defensive snap count totals (out of 78):

CB Janoris Jenkins: 76

S Darian Thompson: 75

S Landon Collins: 75

DE Jason Pierre-Paul: 71

CB Eli Apple: 63

LB Keenan Robinson: 59

LB B.J. Goodson: 59

DT Dalvin Tomlinson: 47

DT Damon Harrison: 45

DE Kerry Wynn: 44

LB Devon Kennard: 42

DT Jay Bromley: 42

CB Dominique Rodgers-Cromartie: 40

CB Ross Cockrell: 35

LB Jonathan Casillas: 35

DE Avery Moss: 29

DE Romeo Okwara: 13

S Nat Berhe: 6

S Andrew Adams: 2

Special teams snap count totals (out of 32):

LB Calvin Munson: 30

LB Curtis Grant: 30

DE Cap Capi: 25

S Andrew Adams: 25

S Nat Berhe: 25

TE Rhett Ellison: 17

DE Kerry Wynn: 16

WR Dwayne Harris: 15

CB Eli Apple: 15

TE Evan Engram: 13

CB Ross Cockrell: 12

LB Devon Kennard: 11

WR Roger Lewis: 10

TE Jerell Adams: 10

LS Zak DeOssie: 10

P Brad Wing: 10

S Landon Collins: 8

RB Shane Vereen: 7

RB Orleans Darkwa: 7

DT Dalvin Tomlinson: 7

RB Wayne Gallman: 6

K Aldrick Rosas: 6

DE Jason Pierre-Paul: 5

DT Jay Bromley: 5

CB Janoris Jenkins: 3

WR Odell Beckham Jr.: 2

OL Bobby Hart: 2

OL Justin Pugh: 2

OL Ereck Flowers: 2

OL John Jerry: 2

OL Chad Wheeler: 2

CB Dominique Rodgers-Cromartie: 2

DE Romeo Okwara: 1

Dan Duggan may be reached at dduggan@njadvancemedia.com. Follow him on Twitter @DDuggan21. Find our Giants coverage on Facebook.