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For 72 years, researchers at Harvard have been examining this question, following 268 men who entered college in the late 1930s through war, career, marriage and divorce, parenthood and grandparenthood, and old age. Here, for the first time, a journalist gains access to the archive of one of the most comprehensive longitudinal studies in history. Its contents, as much literature as science, offer profound insight into the human condition—and into the brilliant, complex mind of the study’s longtime director, George Vaillant. Case No. 218 How’s this for the good life? You’re rich, and you made the dough yourself. You’re well into your 80s, and have spent hardly a day in the hospital. Your wife had a cancer scare, but she’s recovered and by your side, just as she’s been for more than 60 years. Asked to rate the marriage on a scale of 1 to 9, where 1 is perfectly miserable and 9 is perfectly happy, you circle the highest number. You’ve got two good kids, grandkids too. A survey asks you: “If you had your life to live over again, what problem, if any, would you have sought help for and to whom would you have gone?” “Probably I am fooling myself,” you write, “but I don’t think I would want to change anything.” If only we could take what you’ve done, reduce it to a set of rules, and apply it systematically.

Right? Case No. 47 You literally fell down drunk and died. Not quite what the study had in mind. Last fall, I spent about a month in the file room of the Harvard Study of Adult Development, hoping to learn the secrets of the good life. The project is one of the longest-running—and probably the most exhaustive—longitudinal studies of mental and physical well-being in history. Begun in 1937 as a study of healthy, well-adjusted Harvard sophomores (all male), it has followed its subjects for more than 70 years. Interviews:



Ben Bradlee: "I Haven't Been Unhappy in My Life"

The famed editor reflects on his education, career, and experiences as a member of the Grant Study.



Donald Cole: "I Have Always Thought Adaptation Was a Wonderful Thing."

A historian and prep school teacher reflects on his life and how it has been affected by his participation in the study. The famed editor reflects on his education, career, and experiences as a member of the Grant Study.A historian and prep school teacher reflects on his life and how it has been affected by his participation in the study. From their days of bull sessions in Cambridge to their active duty in World War II, through marriages and divorces, professional advancement and collapse—and now well into retirement—the men have submitted to regular medical exams, taken psychological tests, returned questionnaires, and sat for interviews. The files holding the data are as thick as unabridged dictionaries. They sit in a wall of locked cabinets in an office suite behind Fenway Park in Boston, in a plain room with beige carpeting and fluorescent lights that is littered with the detritus of many decades of social-scientific inquiry: a pile of enormous spreadsheet data books; a 1970s-era typewriter; a Macintosh PowerBook, circa 1993. All that’s missing are the IBM punch cards used to analyze the data in the early days.

For 42 years, the psychiatrist George Vaillant has been the chief curator of these lives, the chief investigator of their experiences, and the chief analyst of their lessons. His own life has been so woven into the study—and the study has become such a creature of his mind—that neither can be understood without the other. As Vaillant nears retirement (he’s now 74), and the study survivors approach death—the roughly half still living are in their late 80s—it’s a good time to examine both, and to do so, I was granted unprecedented access to case files ordinarily restricted to researchers. As a young man, Vaillant fell in love with the longitudinal method of research, which tracks relatively small samples over long periods of time (as in Michael Apted’s Seven Up! documentaries). In 1961, as a psychiatric resident at the Massachusetts Mental Health Center, Vaillant found himself intrigued by two patients with manic depression who had 25 years earlier been diagnosed as incurable schizophrenics. Vaillant asked around for other cases of remitted schizophrenia and pulled their charts. “These records hadn’t been assembled to do research,” Vaillant told me recently, “but it was contemporary, real-time information, with none of the errors you get from memory or the distortions you get when you narrate history from the vantage of the present.” In 1967, after similar work following up on heroin addicts, he discovered the Harvard Study, and his jaw dropped. “To be able to study lives in such depth, over so many decades,” he said, “it was like looking through the Mount Palomar telescope,” then the most powerful in the world. Soon after he began to work with the material, he found himself talking about the project to his psychoanalyst. Showing him the key that opened the study cabinets, Vaillant said, “I have the key to Fort Knox.”

Such bravado had defined the study from the start. Arlie Bock—a brusque, no-nonsense physician who grew up in Iowa and took over the health services at Harvard University in the 1930s—conceived the project with his patron, the department-store magnate W. T. Grant. Writing in September 1938, Bock declared that medical research paid too much attention to sick people; that dividing the body up into symptoms and diseases—and viewing it through the lenses of a hundred micro-specialties—could never shed light on the urgent question of how, on the whole, to live well. His study would draw on undergraduates who could “paddle their own canoe,” Bock said, and it would “attempt to analyze the forces that have produced normal young men.” He defined normal as “that combination of sentiments and physiological factors which in toto is commonly interpreted as successful living.” Bock assembled a team that spanned medicine, physiology, anthropology, psychiatry, psychology, and social work, and was advised by such luminaries as the psychiatrist Adolf Meyer and the psychologist Henry Murray. Combing through health data, academic records, and recommendations from the Harvard dean, they chose 268 students—mostly from the classes of 1942, ’43, and ’44—and measured them from every conceivable angle and with every available scientific tool. Exhaustive medical exams noted everything from major organ function, to the measure of lactic acid after five minutes on a treadmill, to the size of the “lip seam” and the hanging length of the scrotum. Using a new test called the electroencephalograph, the study measured the electrical activity in the brain, and sought to deduce character from the squiggles. During a home visit, a social worker took not only a boy’s history—when he stopped wetting his bed, how he learned about sex—but also extensive medical and social histories on his parents and extended family. The boys interpreted Rorschach inkblots, submitted handwriting samples for analysis, and talked extensively with psychiatrists. They stripped naked so that every dimension of their bodies could be measured for “anthropometric” analysis, a kind of whole-body phrenology based on the premise that stock character types could be seen from body proportions.

Inveighing against medicine’s tendency to think small and specialized, Bock made big promises. He told the Harvard Crimson in 1942 that his study of successful men was pitched at easing “the disharmony of the world at large.” One early Grant Study document compared its prospects to the accomplishments of Socrates, Galileo, and Pasteur. But in fact the study staff remained bound by their respective disciplines and by the kinds of narrow topics that yield academic journal papers. Titles from the study’s early years included “Resting-Pulse and Blood-Pressure Values in Relation to Physical Fitness in Young Men”; “Instruction Time in Certain Multiple Choice Tests”; and “Notes on Usage of Male Personal Names.” Perhaps the height of the study’s usefulness in its early days was to lend its methods to the military, for officer selection in World War II. Most longitudinal studies die on the vine because funders expect results quickly. W. T. Grant was no exception. He held on for about a decade—allowing the staff to keep sending detailed annual questionnaires to the men, hold regular case conferences, and publish a flurry of papers and several books—before he stopped sending checks. By the late 1940s, the Rockefeller Foundation took an interest, funding a research anthropologist named Margaret Lantis, who visited every man she could track down (which was all but a few). But by the mid-1950s, the study was on life support. The staff, including Clark Heath, who had managed the study for Bock, scattered, and the project fell into the care of a lone Harvard Health Services psychologist, Charles McArthur. He kept it limping along—surveys dwindled to once every two years—in part by asking questions about smoking habits and cigarette-brand preferences, a nod to a new study patron, Philip Morris. One survey asked, “If you never smoked, why didn’t you?”

It was a far cry from Galileo. But as Vaillant points out, longitudinal studies, like wines, improve with age. And as the Grant Study men entered middle age—they spent their 40s in the 1960s—many achieved dramatic success. Four members of the sample ran for the U.S. Senate. One served in a presidential Cabinet, and one was president. There was a best-selling novelist (not, Vaillant has revealed, Norman Mailer, Harvard class of ’43). But hidden amid the shimmering successes were darker hues. As early as 1948, 20 members of the group displayed severe psychiatric difficulties. By age 50, almost a third of the men had at one time or another met Vaillant’s criteria for mental illness. Underneath the tweed jackets of these Harvard elites beat troubled hearts. Arlie Bock didn’t get it. “They were normal when I picked them,” he told Vaillant in the 1960s. “It must have been the psychiatrists who screwed them up.” Case No. 141 What happened to you? You grew up in a kind of fairy tale, in a big-city brownstone with 11 rooms and three baths. Your father practiced medicine and made a mint. When you were a college sophomore, you described him as thoughtful, funny, and patient. “Once in awhile his children get his goat,” you wrote, “but he never gets sore without a cause.” Your mother painted and served on prominent boards. You called her “artistic” and civic-minded. As a child, you played all the sports, were good to your two sisters, and loved church. You and some other boys from Sunday school—it met at your house—used to study the families in your neighborhood, choosing one every year to present with Christmas baskets. When the garbageman’s wife found out you had polio, she cried. But you recovered fully, that was your way. “I could discover no problems of importance,” the study’s social worker concluded after seeing your family. “The atmosphere of the home is one of happiness and harmony.”

At Harvard, you continued to shine. “Perhaps more than any other boy who has been in the Grant Study,” the staff noted about you, “the following participant exemplifies the qualities of a superior personality: stability, intelligence, good judgment, health, high purpose, and ideals.” Basically, they were in a swoon. They described you as especially likely to achieve “both external and internal satisfactions.” And you seemed well on your way. After a stint in the Air Force—“the whole thing was like a game,” you said—you studied for work in a helping profession. “Our lives are like the talents in the parable of the three stewards,” you wrote. “It is something that has been given to us for the time being and we have the opportunity and privilege of doing our best with this precious gift.” And then what happened? You married, and took a posting overseas. You started smoking and drinking. In 1951—you were 31—you wrote, “I think the most important element that has emerged in my own psychic picture is a fuller realization of my own hostilities. In early years I used to pride myself on not having any. This was probably because they were too deeply buried and I unwilling and afraid to face them.” By your mid-30s, you had basically dropped out of sight. You stopped returning questionnaires. “Please, please … let us hear from you,” Dr. Vaillant wrote you in 1967. You wrote to say you’d come see him in Cambridge, and that you’d return the last survey, but the next thing the study heard of you, you had died of a sudden disease.

Dr. Vaillant tracked down your therapist. You seemed unable to grow up, the therapist said. You had an affair with a girl he considered psychotic. You looked steadily more disheveled. You had come to see your father as overpowering and distant, your mother as overbearing. She made you feel like a black sheep in your illustrious family. Your parents had split up, it turns out. In your last days, you “could not settle down,” a friend told Dr. Vaillant. You “just sort of wandered,” sometimes offering ad hoc therapy groups, often sitting in peace protests. You broke out spontaneously into Greek and Latin poetry. You lived on a houseboat. You smoked dope. But you still had a beautiful sense of humor. “One of the most perplexing and charming people I have ever met in my life,” your friend said. Your obituary made you sound like a hell of a man—a war hero, a peace activist, a baseball fan. In all Vaillant’s literature—and, by agreement, in this essay, too—the Grant Study men remain anonymous. (Even the numbers on the case studies have been changed.) A handful have publicly identified themselves—including Ben Bradlee, the longtime editor of The Washington Post, who opened his memoir, A Good Life, with his first trip to the study office. John F. Kennedy was a Grant Study man, too, though his files were long ago withdrawn from the study office and sealed until 2040. Ironically, it was the notation of that seal in the archive that allowed me to confirm JFK’s involvement, which has not been recognized publicly before now.

Of course, Kennedy—the heir to ruthless, ambitious privilege; the philanderer of “Camelot”; the paragon of casual wit and physical vigor who, backstage, suffered from debilitating illness—is no one’s idea of “normal.” And that’s the point. The study began in the spirit of laying lives out on a microscope slide. But it turned out that the lives were too big, too weird, too full of subtleties and contradictions to fit any easy conception of “successful living.” Arlie Bock had gone looking for binary conclusions—yeses and nos, dos and don’ts. But the enduring lessons would be paradoxical, not only on the substance of the men’s lives (the most inspiring triumphs were often studies in hardship) but also with respect to method: if it was to come to life, this cleaver-sharp science project would need the rounding influence of storytelling. In George Vaillant, the Grant Study found its storyteller, and in the Grant Study, Vaillant found a set of data, and a series of texts, suited to his peculiar gifts. A tall man, with a gravelly voice, steel-gray hair, and eyes that can radiate great joy and deep sadness, Vaillant blends the regal bearing of his old-money ancestors, the emotional directness of his psychiatric colleagues, and a genial absentmindedness. (A colleague recalls one day in the 1980s when Vaillant came to the office in his slippers.) As with many of the men he came to study, Vaillant’s gifts and talents were shaped by his needs and pains. Born in 1934, Vaillant grew up in what he described to me as “blessed circumstances”—living “during the Great Depression with a nurse, a maid, and a cook, but without anybody having so much money that you stared in dismay at the newspapers” as stock prices sagged. And his parents had a storybook romance. They met in Mexico City, where she was the daughter of a prominent expatriate American banker and he was a hotshot archaeologist working on pre-Columbian Aztec digs. When George was 2, he says, his father “gave up being Indiana Jones and became a suit,” first as a curator at the American Museum of Natural History in New York City and then as the director of the University Museum at the University of Pennsylvania in Philadelphia. He was an accomplished man who, his son says, showed little trace of doubt or depression. But one Sunday afternoon in 1945, at home in Devon, Pennsylvania, George Clapp Vaillant, then 44, went out into the yard after a nap. His wife found him by the pool, a revolver next to him and a fatal wound through the mouth. His elder son and namesake, the last to see his father alive, was 10 years old.

Immediately, a curtain of silence fell around the tragedy. “In WASP fashion,” Vaillant says, “it was handled with ‘Let’s get this put away as quickly as possible.’” His mother, Suzannah Beck Vaillant, picked up the children and took them to Arizona. “We never saw our house again,” says Henry Vaillant, George’s younger brother. “We never attended the memorial service. It was just kind of a complete cutoff.” A few years later, their father’s 25th-reunion book, hardbound in red cloth, arrived in the mail from Harvard College. George spent days with it, spellbound by the photographs and words that showed college students morphing, over the course of a few paragraphs, into 47-year-olds. The seed of interest in longitudinal research had been planted; it germinated decades later in Vaillant’s psychiatric residency and then in the ultimate vein of data he discovered at Harvard. It was 1967, and the Grant Study men were beginning to return for their 25th college reunions. Vaillant was 33. He would spend the rest of his career—and expects to spend the rest of his life—following these men. The range of his training and the complexity of his own character proved to be crucial to his research. After Harvard College (where he wrote for the Lampoon, the humor magazine, and studied history and literature), Harvard Medical School, and a residency at the Massachusetts Mental Health Center, Vaillant studied at the Boston Psychoanalytic Institute, which he calls a “temple” to Freud’s ideas. He learned the orthodoxy, which included a literary approach to human lives, bringing theory to bear through deep reading of individual cases. But he also had training in the rigors of data-driven experimental science, including a two-year fellowship at a Skinnerian laboratory, where he studied neurotransmitter levels in pigeons and monkeys. There he learned to use the behaviorist B. F. Skinner’s “cumulative behavioral recorder,” which collapses behaviors across minutes, hours, or days onto a chart to be inspected in a single sitting.

The undertones of psychoanalysis are tragic; Freud dismissed the very idea of “normality” as “an ideal fiction” and famously remarked that he hoped to transform “hysterical misery into common unhappiness.” The spirit of modern social science, by contrast, draws on a brash optimism that the secrets to life can be laid bare. Vaillant is an optimist marinated in tragedy, not just in his life experience, but in his taste. Above his desk hangs a letter from a group of his medical residents to their successors, advising them to prepare for Vaillant’s “obscure literary references” by reading Tennessee Williams’s The Glass Menagerie, Arthur Miller’s Death of a Salesman, and Henrik Ibsen’s A Doll’s House. Vaillant loves Dostoyevsky and Tolstoy, too, and the cartoons of the dark humorist Charles Addams, like the one where several Christmas carolers sing merrily at the Addams family doorstep, while Morticia, Lurch, and Gomez stand on the roof, ready to tip a vat of hot oil on their heads. When his children were small, Vaillant would read them a poem about a tribe of happy-go-lucky bears, who lived in a kind of Eden until a tribe of mangier, smarter bears came along and enslaved them. “I would weep at this story,” remembers his daughter Anne Vaillant. “Dad thought it was funny, and I think somehow it was helpful to him that I had such feelings about it. There was this sort of, ‘This is the way life is.’”

Yet, even as he takes pleasure in poking holes in an innocent idealism, Vaillant says his hopeful temperament is best summed up by the story of a father who on Christmas Eve puts into one son’s stocking a fine gold watch, and into another son’s, a pile of horse manure. The next morning, the first boy comes to his father and says glumly, “Dad, I just don’t know what I’ll do with this watch. It’s so fragile. It could break.” The other boy runs to him and says, “Daddy! Daddy! Santa left me a pony, if only I can just find it!” The story gets to the heart of Vaillant’s angle on the Grant Study. His central question is not how much or how little trouble these men met, but rather precisely how—and to what effect—they responded to that trouble. His main interpretive lens has been the psychoanalytic metaphor of “adaptations,” or unconscious responses to pain, conflict, or uncertainty. Formalized by Anna Freud on the basis of her father’s work, adaptations (also called “defense mechanisms”) are unconscious thoughts and behaviors that you could say either shape or distort—depending on whether you approve or disapprove—a person’s reality. Vaillant explains defenses as the mental equivalent of a basic biological process. When we cut ourselves, for example, our blood clots—a swift and involuntary response that maintains homeostasis. Similarly, when we encounter a challenge large or small—a mother’s death or a broken shoelace—our defenses float us through the emotional swamp. And just as clotting can save us from bleeding to death—or plug a coronary artery and lead to a heart attack—defenses can spell our redemption or ruin. Vaillant’s taxonomy ranks defenses from worst to best, in four categories.

At the bottom of the pile are the unhealthiest, or “psychotic,” adaptations—like paranoia, hallucination, or megalomania—which, while they can serve to make reality tolerable for the person employing them, seem crazy to anyone else. One level up are the “immature” adaptations, which include acting out, passive aggression, hypochondria, projection, and fantasy. These aren’t as isolating as psychotic adaptations, but they impede intimacy. “Neurotic” defenses are common in “normal” people. These include intellectualization (mutating the primal stuff of life into objects of formal thought); dissociation (intense, often brief, removal from one’s feelings); and repression, which, Vaillant says, can involve “seemingly inexplicable naïveté, memory lapse, or failure to acknowledge input from a selected sense organ.” The healthiest, or “mature,” adaptations include altruism, humor, anticipation (looking ahead and planning for future discomfort), suppression (a conscious decision to postpone attention to an impulse or conflict, to be addressed in good time), and sublimation (finding outlets for feelings, like putting aggression into sport, or lust into courtship). In contrast to Anna Freud, who located the origins of defenses in the sexual conflicts of a child, Vaillant sees adaptations as arising organically from the pain of experience and playing out through the whole lifespan. Take his comparison of two Grant Study men, whom he named “David Goodhart” and “Carlton Tarrytown” in his first book on the study, Adaptation to Life, published in 1977. Both men grew up fearful and lonely. Goodhart was raised in a blue-collar family, had a bigoted, alcoholic father, and a mother he described as “very nervous, irritable, anxious, and a worrier.” Tarrytown was richer, and was raised in a wealthy suburb, but he also had an alcoholic father, and his mother was so depressed that he feared she would commit suicide. Goodhart went on to become a national leader on civil-rights issues—a master, Vaillant argued, of the “mature” defenses of sublimation and altruism. By his late 40s, staff researchers using independent ratings put Goodhart in the top fifth of the Grant Study in psychological adjustment. Tarrytown, meanwhile, was in the bottom fifth. A doctor who left a regular practice to work for the state, a three-time divorcé who anesthetized his pain with alcohol and sedatives, Tarrytown was, Vaillant said, a user of dissociation and projection—“neurotic” and “immature” defenses, respectively. After a relapse into drug abuse, Tarrytown killed himself at 53. Goodhart lived to 70. Though Vaillant says that the “dashing major” of midlife became a stolid and portly brigadier general, Goodhart’s obituaries still celebrated a hero of civil rights.

Most psychology preoccupies itself with mapping the heavens of health in sharp contrast to the underworld of illness. “Social anxiety disorder” is distinguished from shyness. Depression is defined as errors in cognition. Vaillant’s work, in contrast, creates a refreshing conversation about health and illness as weather patterns in a common space. “Much of what is labeled mental illness,” Vaillant writes, “simply reflects our ‘unwise’ deployment of defense mechanisms. If we use defenses well, we are deemed mentally healthy, conscientious, funny, creative, and altruistic. If we use them badly, the psychiatrist diagnoses us ill, our neighbors label us unpleasant, and society brands us immoral.” This perspective is shaped by a long-term view. Whereas clinicians focus on treating a problem at any given time, Vaillant is more like a biographer, looking to make sense of a whole life—or, to take an even broader view, like an anthropologist or naturalist looking to capture an era. The good news, he argues, is that diseases—and people, too—have a “natural history.” After all, many of the “psychotic” adaptations are common in toddlers, and the “immature” adaptations are essential in later childhood, and they often fade with maturity. As adolescents, the Grant Study men were twice as likely to use immature defenses as mature ones, but in middle life they were four times as likely to use mature defenses—and the progress continued into old age. When they were between 50 and 75, Vaillant found, altruism and humor grew more prevalent, while all the immature defenses grew more rare.

This means that a glimpse of any one moment in a life can be deeply misleading. A man at 20 who appears the model of altruism may turn out to be a kind of emotional prodigy—or he may be ducking the kind of engagement with reality that his peers are both moving toward and defending against. And, on the other extreme, a man at 20 who appears impossibly wounded may turn out to be gestating toward maturity. Such was the case, Vaillant argues, with “Dr. Godfrey Minot Camille,” a poetic and troubled young man who spent so much time at the Harvard infirmary complaining of vague symptoms that a college physician declared, “This boy is becoming a regular psychoneurotic.” He’d grown up in a frigid environment—he ate his meals alone until age 6—and spoke of his desolation with heartbreaking clarity. A member of the study staff advised him: “When you come to the end of your rope, tie a knot and hold on.” He replied: “But the knot was tied so long ago, and I have been hanging on tight for such a long time.” After graduating from medical school, he attempted suicide. With the help of psychotherapy and with the passage of time, his hypochondria eased and he began to show “displacement,” the strategy of shifting preoccupations from a painful source to more neutral ground. When his sister died, he sent her autopsy report to the Grant Study office, with a cool note saying that he expected it would be “an item of news.” He reported another family death this way: “I received an inheritance from my mother.”

For Camille, such detached neutrality seemed to herald progress. At 35, he spent 14 months in a hospital for an infection and had what he described as a spiritual awakening. “Someone with a capital ‘S’ cared about me,” he wrote. Afterward, he bloomed as a psychiatrist, channeling his own needs into service. He said he liked the “distant closeness” of psychotherapy—and liked getting paid for it. As a child, he had fantasized about being a minister or physician. “Finally, at age forty, wish became behavior,” Vaillant wrote. In his 2002 book, Aging Well, Vaillant returned to this man’s story, this time calling him “Ted Merton” to emphasize his spiritual development. (The men in Vaillant’s books always have florid pseudonyms—Horace Lamb, Frederick Lion, Bill Loman, etc.) In several vignettes in the book, Vaillant presents Merton as an exemplar of how mature adaptations are a real-life alchemy, a way of turning the dross of emotional crises, pain, and deprivation into the gold of human connection, accomplishment, and creativity. “Such mechanisms are analogous to the involuntary grace by which an oyster, coping with an irritating grain of sand, creates a pearl,” he writes. “Humans, too, when confronted with irritants, engage in unconscious but often creative behavior.” But “creative” doesn’t equate to ease. At ages 55 and 60, Merton had severe depressions. In the first instance he was hospitalized. The second instance coincided with his second divorce, and “he lost not only his wife, his savings, and his job, but even his network of professional colleagues.” Going forth into the breach of life can deepen meaning, but also deepen wounds. Case No. 158

An attractive, amiable boy from a working-class background, you struck the study staff as happy, stable, and sociable. “My general impression is that this boy will be normal and well-adjusted—rather dynamic and positive,” the psychiatrist reported. After college, you got an advanced degree and began to climb the rungs in your profession. You married a terrific girl, and you two played piano together for fun. You eventually had five kids. Asked about your work in education, you said, “What I am doing is not work; it is fun. I know what real work is like.” Asked at age 25 whether you had “any personal problems or emotional conflicts (including sexual),” you answered, “No … As Plato or some of your psychiatrists might say, I am at present just ‘riding the wave.’” You come across in your files as smart, sensible, and hard-working. “This man has always kept a pleasant face turned toward the world,” Dr. Heath noted after a visit from you in 1949. From your questionnaire that year, he got “a hint … that everything has not been satisfactory” at your job. But you had no complaints. After interviewing you at your 25th reunion, Dr. Vaillant described you as a “solid guy.” Two years later, at 49, you were running a major institution. The strain showed immediately. Asked for a brief job description, you wrote: “RESPONSIBLE (BLAMED) FOR EVERYTHING.” You added, “No matter what I do … I am wrong … We are just ducks in a shooting gallery. Any duck will do.” On top of your job troubles, your mother had a stroke, and your wife developed cancer. Three years after you started the job, you resigned before you could be fired. You were 52, and you never worked again. (You kept afloat with income from stock in a company you’d done work for, and a pension.)

Seven years later, Dr. Vaillant spoke with you: “He continued to obsess … about his resignation,” he wrote. Four years later, you returned to the subject “in an obsessional way.” Four years later still: “It seemed as if all time had stopped” for you when you resigned. “At times I wondered if there was anybody home,” Dr. Vaillant wrote. Your first wife had died, and you treated your second wife “like a familiar old shoe,” he said. But you called yourself happy. When you were 74, the questionnaire asked: “Have you ever felt so down in the dumps that nothing could cheer you up?” and gave the options “All of the time, some of the time, none of the time.” You circled “None of the time.” “Have you felt calm and peaceful?” You circled “All of the time.” Two years later, the study asked: “Many people hope to become wiser as they grow older. Would you give an example of a bit of wisdom you acquired and how you came by it?” You wrote that, after having polio and diphtheria in childhood, “I never gave up hope that I could compete again. Never expect you will fail. Don’t cry, if you do.” What allows people to work, and love, as they grow old? By the time the Grant Study men had entered retirement, Vaillant, who had then been following them for a quarter century, had identified seven major factors that predict healthy aging, both physically and psychologically. Employing mature adaptations was one. The others were education, stable marriage, not smoking, not abusing alcohol, some exercise, and healthy weight. Of the 106 Harvard men who had five or six of these factors in their favor at age 50, half ended up at 80 as what Vaillant called “happy-well” and only 7.5 percent as “sad-sick.” Meanwhile, of the men who had three or fewer of the health factors at age 50, none ended up “happy-well” at 80. Even if they had been in adequate physical shape at 50, the men who had three or fewer protective factors were three times as likely to be dead at 80 as those with four or more factors.

What factors don’t matter? Vaillant identified some surprises. Cholesterol levels at age 50 have nothing to do with health in old age. While social ease correlates highly with good psychosocial adjustment in college and early adulthood, its significance diminishes over time. The predictive importance of childhood temperament also diminishes over time: shy, anxious kids tend to do poorly in young adulthood, but by age 70, are just as likely as the outgoing kids to be “happy-well.” Vaillant sums up: “If you follow lives long enough, the risk factors for healthy life adjustment change. There is an age to watch your cholesterol and an age to ignore it.” The study has yielded some additional subtle surprises. Regular exercise in college predicted late-life mental health better than it did physical health. And depression turned out to be a major drain on physical health: of the men who were diagnosed with depression by age 50, more than 70 percent had died or were chronically ill by 63. More broadly, pessimists seemed to suffer physically in comparison with optimists, perhaps because they’re less likely to connect with others or care for themselves. More than 80 percent of the Grant Study men served in World War II, a fact that allowed Vaillant to study the effect of combat. The men who survived heavy fighting developed more chronic physical illnesses and died sooner than those who saw little or no combat, he found. And “severity of trauma is the best predictor of who is likely to develop PTSD.” (This may sound obvious, but it countered the claim that post-traumatic stress disorder was just the manifestation of preexisting troubles.) He also found that personality traits assigned by the psychiatrists in the initial interviews largely predicted who would become Democrats (descriptions included “sensitive,” “cultural,” and “introspective”) and Republicans (“pragmatic” and “organized”).

Again and again, Vaillant has returned to his major preoccupations. One is alcoholism, which he found is probably the horse, and not the cart, of pathology. “People often say, ‘That poor man. His wife left him and he’s taken to drink,’” Vaillant says. “But when you look closely, you see that he’s begun to drink, and that has helped drive his wife away.” The horrors of drink so preoccupied Vaillant that he devoted a stand-alone study to it: The Natural History of Alcoholism. Vaillant’s other main interest is the power of relationships. “It is social aptitude,” he writes, “not intellectual brilliance or parental social class, that leads to successful aging.” Warm connections are necessary—and if not found in a mother or father, they can come from siblings, uncles, friends, mentors. The men’s relationships at age 47, he found, predicted late-life adjustment better than any other variable, except defenses. Good sibling relationships seem especially powerful: 93 percent of the men who were thriving at age 65 had been close to a brother or sister when younger. In an interview in the March 2008 newsletter to the Grant Study subjects, Vaillant was asked, “What have you learned from the Grant Study men?” Vaillant’s response: “That the only thing that really matters in life are your relationships to other people.” The authority of these findings stems in large part from the rarity of the source. Few longitudinal studies survive in good health for whole lifetimes, because funding runs dry and the participants drift away. Vaillant managed, drawing on federal grants and private gifts, to finance surveys every two years, physicals every five years, and interviews every 15 years. The original study social worker, Lewise Gregory Davies, helped him goad the subjects to stay in touch, but it wasn’t a hard sell. The Grant Study men saw themselves as part of an elite club.