Sen. Lisa Murkowski Lisa Ann MurkowskiGOP ramps up attacks on Democrats over talk of nixing filibuster OVERNIGHT ENERGY: House Democrats tee up vote on climate-focused energy bill next week | EPA reappoints controversial leader to air quality advisory committee | Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' House Democrats tee up vote on climate-focused energy bill next week MORE (R-Alaska) announced that she would not be voting for President Trump’s pick to lead the Education Department, becoming the second Republican senator to oppose Betsy DeVos's nomination.

ADVERTISEMENT

Murkowski made her announcement on the Senate floor, just after GOP Sen. Susan Collins Susan Margaret CollinsGOP short of votes on Trump's controversial Fed pick Congress must save the Postal Service from collapse — our economy depends on it Garcetti: I would have acted sooner if Trump hadn't downplayed virus MORE (Maine) announced she would oppose DeVos.

The pair are the first two Republicans to break with President Trump on his Cabinet nominees. Their no votes will make it difficult for DeVos to be confirmed. Republicans hold 52 seats in the Senate. If every Democrat votes against DeVos, Vice President Pence could break the tie.

No Democrats have said they will vote for DeVos.

"I have serious concerns about a nominee to be secretary of Education ... who has been so immersed in the discussion of vouchers," she said.

"I do not intend to vote on final passage to support Ms. DeVos to be secretary of Education," she said.