Dan Orlovsky and Rob Ninkovich think the Chiefs defense will be a major factor against the Jaguars. (0:43)

Football is back, and we're previewing the Week 1 NFL slate. Our NFL Nation reporters bring us the keys to every game, a bold prediction for each matchup and final score predictions.

Additionally, ESPN Stats & Information provides a stat to know, and the Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1-100) and a game projection. ESPN Fantasy's Kyle Soppe and ESPN Chalk's Mackenzie Kraemer hand out helpful nuggets, as well. It's all here to help get you ready for a loaded weekend of NFL football.

Let's get into the full Week 1 schedule, starting with an AFC showdown between the Chiefs and Jaguars.

Jump to a matchup:

KC-JAX | LAR-CAR | ATL-MIN

TEN-CLE | WSH-PHI | BUF-NYJ

BAL-MIA | IND-LAC | CIN-SEA

NYG-DAL | SF-TB | DET-ARI

PIT-NE | HOU-NO | DEN-OAK

Thursday: GB 10, CHI 3

1 p.m. ET | CBS

Matchup rating: 75.2 | Spread: KC -3.5 (50)

What to watch for: Nobody is really sure what to expect out of the Jaguars' offense under new coordinator John DeFilippo and quarterback Nick Foles. Can the Jags score 30-plus points? That's what it'll probably take to beat the Chiefs, who look just as potent as they were last season. -- Michael DiRocco

Bold prediction: Patrick Mahomes will throw at least two touchdown passes. That might not sound like a big deal for a QB who threw 50 of them last season, but remember the Jaguars were the only team to shut him out in that category in the regular season last year. -- Adam Teicher

Stat to know: Tyreek Hill scored on each of his first two touches of the 2018 season (against the Chargers), a 91-yard punt return and a 58-yard reception. He has a league-high 302 receiving yards in season openers over the past two years, but the Jaguars did limit him to only four receptions for 61 yards in Week 5 last season.

What to know for fantasy: Mahomes posted the best fantasy season ever by a quarterback (417.1 points), but the Jags are the fourth-best defense against quarterbacks since Doug Marrone took over in 2016. Only once last season did a QB go into Jacksonville and score 21-plus points (Carson Wentz). See Week 1 rankings.

Betting nugget: Foles has covered seven straight games as an underdog, including six outright wins. Read more.

Teicher's pick: Chiefs 34, Jaguars 24

DiRocco's pick: Chiefs 31, Jaguars 20

FPI prediction: KC, 58.2% (by an average of 3.0 points)

Matchup must-reads: Chiefs 'expect to score every single time' and break downward trend ... Foles getting rare second chance to be franchise QB ... Foles lost his love for football; the Chiefs helped him find it

1 p.m. ET | Fox

Matchup rating: 69.6 | Spread: LAR -1.5 (50)

What to watch for: Don't be surprised if Cam Newton tests his throwing shoulder early with at least two deep throws, probably to Curtis Samuel, to make the Rams play honest. He also won't be hesitant to run. He led the Panthers in rushing in last year's opener. -- David Newton

Bold prediction: Todd Gurley will rush for more than 100 yards and will add a touchdown. He returns to the state where he grew up for the first time as a pro and is coming off arguably his most challenging offseason because of endless chatter about his left knee. -- Lindsey Thiry

Stat to know: Jared Goff led the NFL with 116 completions of 10-plus air yards last season. The Panthers, meanwhile, gave up 16 passing touchdowns of at least 10 air yards in 2018, tied for the third most in the NFL.

What to know for fantasy: Wide receiver Cooper Kupp returns to action after tearing his ACL last season. Kupp caught at least five passes in six of eight games last season and is averaging 1.3 red zone targets per game during his career (seventh best). See Week 1 rankings.

Betting nugget: Super Bowl losers from the previous season are 3-16 against the spread (ATS) in Week 1 the following season since 2000. Read more.

play 0:43 Ninkovich: Rams win if Cam isn't 100% Rob Ninkovich and Dan Orlovsky agree that Cam Newton's ankle injury will hold him back, and Aaron Donald will be the X factor for the Rams.

Thiry's pick: Rams 28, Panthers 24

Newton's pick: Panthers 27, Rams 23

FPI prediction: LAR, 51.1% (by an average of 0.5 points)

Matchup must-reads: McVay: Defending Newton-McCaffrey duo a 'nightmare' ... Rams back up money truck to ensure Goff-McVay connection ... Fully healthy, Cam feeling 'like a rookie again' ... McVay provides compass for Rams to navigate past Super Bowl

1 p.m. ET | Fox

Matchup rating: 66.3 | Spread: MIN -3.5 (47)

What to watch for: The Julio Jones-Xavier Rhodes matchup is always popcorn-worthy. A healthy Rhodes limited Jones to two catches for 24 yards in 2017 during one of his best years as a pro. But he is coming off a season riddled with injuries. -- Courtney Cronin

Bold prediction: Miami friends and former Florida State Seminoles Dalvin Cook and Devonta Freeman will each go for 100 rushing yards. But it's Cook and the Vikings who come up with the win. -- Vaughn McClure

Stat to know: Matt Ryan's 4,924 passing yards were third in the NFL last season, but the Vikings gave up only 196.3 passing yards per game -- also third in NFL.

What to know for fantasy: The Falcons have given up the most running-back receptions in each of the past four seasons, and Cook ranked seventh among running backs in receptions last December. See Week 1 rankings.

Betting nugget: Mike Zimmer is 52-29-2 ATS as a head coach, the best mark by any coach in the Super Bowl era (minimum 50 games), including 29-12-1 at home. Read more.

McClure's pick: Vikings 24, Falcons 21

Cronin's pick: Vikings 24, Falcons 20

FPI prediction: MIN, 59.2% (by an average of 3.4 points)

Matchup must-reads: 'I get to be me again': Healthy Cook eyeing big Year 3 ... How 34-year-old Ryan stays young ... Vikings have big plans for TE Smith, but history suggests patience

1 p.m. ET | CBS

Matchup rating: 53.9 | Spread: CLE -5.5 (45)

What to watch for: The unveiling of the Baker Mayfield-Odell Beckham Jr. passing connection, which has a chance to be among the elite in the NFL, will be reason enough to tune in. How the duo fares in its debut will offer a glimpse of how dynamic this Browns offense can be in 2019. -- Jake Trotter

Bold prediction: The Browns' offense is potent, but it will take time to get rolling in the season opener against a Titans defense that catches Cleveland at the perfect time. Derrick Henry runs for 125 yards and a touchdown. -- Turron Davenport

Stat to know: Henry led the NFL with 585 rushing yards and seven rushing touchdowns over the final four weeks of last season. That success came from his bruising running style, as he led the NFL with 2.85 yards after contact per rush.

What to know for fantasy: Mayfield was the only quarterback to throw for three touchdowns in Week 16 and Week 17 last season. See Week 1 rankings.

Betting nugget: Cleveland is 0-13-1 outright and 4-9-1 ATS in its past 14 Week 1 games, but it did cover each of its past two season openers. Read more.

Davenport's pick: Titans 24, Browns 17

Trotter's pick: Browns 28, Titans 17

FPI prediction: CLE, 56.6% (by an average of 2.5 points)

Matchup must-reads: Chubb primed for Year 2, and 1K season that got away ... How will Titans fare without Lewan against Browns' pass-rushers?

1 p.m. ET | Fox

Matchup rating: 47.9 | Spread: PHI -10.5 (44.5)

What to watch for: The Eagles are anticipating Washington cornerback Josh Norman will shadow Alshon Jeffery most of the game. That's all the more reason for Carson Wentz to target his other outside receiver, DeSean Jackson, who has a history of monster games against his former teams. -- Tim McManus

Bold prediction: Tight ends will do most of the damage in this matchup. The Redskins' Jordan Reed will catch five passes for 70 yards and a touchdown, and Eagles tight end Zach Ertz will continue his domination of Washington with seven catches for 80 yards and a score of his own. -- John Keim

Stat to know: The Eagles are 8-2 in their past 10 season openers, tied for the best season-opening record in the NFL (with the Broncos and Patriots) during that span. Meanwhile, the Redskins have lost five of their past six season openers.

What to know for fantasy: Wentz was one of three quarterbacks to throw for 300 yards and multiple touchdowns against the Redskins last season. See Week 1 rankings.

Betting nugget: Philadelphia is 5-1 ATS in its past six season openers, and Washington is 1-5 ATS in that same span. Read more.

Keim's pick: Eagles 24, Redskins 13

McManus' pick: Eagles 27, Redskins 17

FPI prediction: PHI, 77.9% (by an average of 11.1 points)

Matchup must-reads: Pederson's message to Wentz: 'Let the team work for you' ... DeSean Jackson is out for redemption ... Jay Gruden: Redskins' defense has chance 'to be special' ... Eagles linemen want to bust the 'O-line body' stigma

1 p.m. ET | CBS

Matchup rating: 31.4 | Spread: NYJ -2.5 (40.5)

What to watch for: Jets running back Le'Veon Bell makes his much-anticipated return to the NFL after sitting out the 2018 season because of a contract dispute with the Steelers. And second-year QBs Sam Darnold and Josh Allen, who are close friends, meet for the second time in what figures to be a long personal rivalry within the AFC East. Darnold leads Allen 1-0. -- Rich Cimini

Bold prediction: Devin Singletary will score two touchdowns. The rookie running back has a role on the ground and in the passing game, and will find his way into the end zone in both capacities Sunday. -- Marcel Louis-Jacques

Stat to know: Allen averaged 10.5 air yards per attempt last season for Buffalo, the second-highest rate in the NFL -- but he completed just 37% of his throws more than 10 yards downfield, which was the worst mark in the league.

What to know for fantasy: Bell was RB2 the last time we saw him (2017), averaging 22.8 points per game. And there were four running backs last season who scored over 25 points in a game against the Bills (Marlon Mack, Melvin Gordon, Leonard Fournette and James White). See Week 1 rankings.

play 0:38 Ninkovich: Jets will be all jacked up vs. Bills Dan Orlovsky and Rob Ninkovich agree that with the Jets playing at home and having Le'Veon Bell will be too much for the Bills.

Betting nugget: The underdog has won five of the past six -- and nine of the past 11 -- meetings between these two teams outright. Read more.

Louis-Jacques' pick: Bills 24, Jets 16

Cimini's pick: Jets 21, Bills 20

FPI prediction: NYJ, 59.3% (by an average of 3.4 points)

Matchup must-reads: Why Gore keeps grinding for another NFL season ... Mosley embraces new start but won't let go of his past ... Gase's plan for Darnold: Play like Peyton

1 p.m. ET | CBS

Matchup rating: 27.1 | Spread: BAL -7 (40)

What to watch for: Dolphins coaches' eyes widened when Baltimore quarterback Lamar Jackson was mentioned this week, and they highlighted his passing game improvement from Year 1 to Year 2. "This is not a one-trick pony," coach Brian Flores said. -- Cameron Wolfe

Bold prediction: Jackson gains over 100 yards rushing. He's opening the season against a Dolphins defense that allowed Bills QB Josh Allen to rush for 135 and 95 yards in two meetings last December. -- Jamison Hensley

Stat to know: The Ravens have scored 54 unanswered points versus the Dolphins, including a 40-0 win in Week 8 of 2017. And the Ravens went 6-1 after naming Jackson the starting quarterback in Week 10 of 2018.

What to know for fantasy: Jackson ranked sixth in rush attempts and seventh in rushing yards over the final seven weeks of 2018 ... among all positions. Over that stretch, Jackson had more rushing yards (556) and rushing touchdowns (4) than Christian McCaffrey. See Week 1 rankings.

Betting nugget: Baltimore has covered each of the past eight meetings. But Miami has covered six straight season openers, the longest active streak in the league. Read more.

Hensley's pick: Ravens 26, Dolphins 10

Wolfe's pick: Ravens 24, Dolphins 13

FPI prediction: BAL, 63.1% (by an average of 4.9 points)

Matchup must-reads: Harbaugh's T-shirt game is motivating the Ravens ... Tanking or not, Dolphins risk losing players' trust with current plan ... Decline at 29? Ingram set to deliver his rebuttal

4:05 p.m. ET | CBS

Matchup rating: 55.8 | Spread: LAC -6.5 (44.5)

What to watch for: With Andrew Luck's surprising retirement, how Jacoby Brissett plays in his absence will go a long way in determining the outcome. Head coach Frank Reich said Brissett just has to play within himself. "The message is you don't have to be a hero," Reich said. -- Eric D. Williams

Bold prediction: Running back Marlon Mack will rush for more than 100 yards. Mack rushed for 908 yards despite missing four games last season, and the Chargers gave up an average of 101.6 yards per game rushing last season and will be without starting Pro Bowl safety Derwin James (foot). -- Mike Wells

Stat to know: The Bolts are 19-6 (.760) against the AFC South with Philip Rivers at quarterback, and the Colts have lost nine of their past 11 overall with Brissett as their starting quarterback.

What to know for fantasy: For his career, T.Y. Hilton averages 1.76 fantasy points per target from Luck. That number dips with Brissett under center, but not as much as you might assume: 1.71 points per target (less than a 3% drop-off). See Week 1 rankings.

Betting nugget: Indianapolis is 1-10 ATS in Week 1 in the past 11 seasons (2-9 straight up). Read more.

Wells' pick: Chargers 21, Colts 17

Williams' pick: Chargers 23, Colts 20

FPI prediction: LAC, 67.8% (by an average of 6.7 points)

Matchup must-reads: Colts confident Brissett won't flinch amid search for next franchise QB ... Ekeler, Jackson ready to share RB load with Gordon out

4:05 p.m. ET | CBS

Matchup rating: 46.1 | Spread: SEA -10 (44)

What to watch for: The debuts of Jadeveon Clowney, Ezekiel Ansah and Zac Taylor are the headlines for this one. Seattle will want to ease Clowney (holdout) and Ansah (shoulder) in given that both are coming off extended absences, so don't expect a full workload from either. And Taylor will have his hands full in his debut as Cincinnati's new head coach. -- Brady Henderson

Bold prediction: Clowney will have two sacks in his Seattle debut. He probably will be lined up against backup left tackle Andre Smith, the veteran who was signed two days before training camp. -- Ben Baby

Stat to know: Joe Mixon rushed for 1,168 yards (fourth in the NFL) last season, and he now faces a Seahawks defense that gave up the third-most yards per rush (4.95).

What to know for fantasy: In 2018, only Ezekiel Elliott had more runs of 15-plus yards than Mixon (23). See Week 1 rankings.

Betting nugget: Seattle has won 10 straight home openers and is 7-2 ATS in nine home openers under Pete Carroll. Read more.

Baby's pick: Seahawks 31, Bengals 14

Henderson's pick: Seahawks 27, Bengals 17

FPI prediction: SEA, 77.0% (by an average of 10.7 points)

Matchup must-reads: Seahawks' 2-for-1 exchange: Clark out, Ansah and Clowney in ... Seahawks steal Clowney even if he's a one-year rental ... Cincinnati again serves as pivotal opportunity for Bengals' Taylor ... Dalton brushing off pressure entering pivotal season

4:25 p.m. ET | Fox

Matchup rating: 42.8 | Spread: DAL -7.5 (45.5)

What to watch for: How much will Ezekiel Elliott play after returning from his holdout and only three practices? In 2017, Elliott returned from a suspension and carried the ball 51 times for 200 yards in the final two games. This time he returns from a holdout with only one padded practice. -- Todd Archer

Bold prediction: Jason Witten will have close to 100 yards receiving and two touchdowns in his first game out of retirement. The Dallas tight end has always feasted against the Giants, which includes four touchdowns in his past five games against them. -- Jordan Raanan

Stat to know: When the Giants have more blockers than defenders in the box, Saquon Barkley takes full advantage. NFL Next Gen Stats has the Giants running back at 6.4 yards per rush last season in that situation, the highest rate of any RB with at least 40 such carries.

What to know for fantasy: Barkley scored 49 total fantasy points in his two games against the Cowboys last season and did so in a variety of ways (14 catches in the first game, 109 yards on the ground in the second one). See Week 1 rankings.

Betting nugget: New York was 7-1 ATS on the road last season, the best mark in the league. Read more.

play 0:40 Orlovsky: Zeke is going to bring some juice to Cowboys Dan Orlovsky and Rob Ninkovich like the Cowboys' chances vs. the Giants, especially with Ezekiel Elliott back.

Raanan's pick: Cowboys 26, Giants 16

Archer's pick: Cowboys 27, Giants 17

FPI prediction: DAL, 75.3% (by an average of 9.9 points)

Matchup must-reads: Jerry Jones pays Elliott: Time for Cowboys to win Super Bowl ... Why Engram might be Giants' No. 1 receiver ... Garrett is coaching for his job but you wouldn't know it

4:25 p.m. ET | Fox

Matchup rating: 42.3 | Spread: TB -1 (51)

What to watch for: The Bucs might have a strong vertical passing attack under Bruce "No Risk It, No Biscuit" Arians, but the Niners' pass rush could really do some damage up front against an offensive line that surrendered a whopping 19 sacks in the preseason. -- Jenna Laine

Bold prediction: The 49ers will match their interception total from all of last season by picking off Jameis Winston twice -- but Buccaneers receiver Mike Evans will have a huge game to even things out. -- Nick Wagoner

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Stat to know: Niners tight end George Kittle gained 855 of his 1,377 receiving yards last season after the catch, the most by any player since YAC was first tracked in 2006.

What to know for fantasy: Only two teams gave up more deep touchdown passes than the 49ers last season, and Winston led the league in air yards per pass attempt. See Week 1 rankings.

Betting nugget: San Francisco is 0-7 ATS and straight up in its past seven games where the total was in the 50s. Read more.

Wagoner's pick: Buccaneers 27, 49ers 24

Laine's pick: Buccaneers 24, 49ers 16

FPI prediction: TB, 52.0% (by an average of 0.8 points)

Matchup must-reads: 49ers must figure out what they have in Garoppolo in 2019 ... What's shaping Winston's fate with the Bucs in 2019?

4:25 p.m. ET | Fox

Matchup rating: 25.0 | Spread: DET -2.5 (46)

What to watch for: The Cardinals' offense has been a tightly kept secret since coach Kliff Kingsbury was hired in January, leaving plenty of questions about how much Arizona will throw the ball. This will be our first real look. -- Josh Weinfuss

Bold prediction: Arizona QB Kyler Murray ends up with 125 yards passing and 50 yards rushing in the first half, but the Lions' defense stifles him in the second half to force turnovers and give Detroit a come-from-behind win. -- Michael Rothstein

Stat to know: Both Murray and Kingsbury are set to make their NFL debuts. According to Elias Sports Bureau research, they would be the third-youngest quarterback-head coach duo to make their NFL debuts in the same game since the merger in 1970 (the Raiders' Steve Beuerlein and Mike Shanahan in 1988, and the Colts' Bert Jones and Howard Schnellenberger in 1973).

What to know for fantasy: Kerryon Johnson was RB10 over his final two games of 2018, and he gets a Cardinals defense that allowed the second-most fantasy points to opposing RBs last season. See Week 1 rankings.

Betting nugget: Quarterbacks making their first career starts are 9-1-1 ATS since 2013 (8-0-1 ATS as the underdog). Read more.

Rothstein's pick: Lions 27, Cardinals 20

Weinfuss' pick: Lions 30, Cardinals 28

FPI prediction: DET, 50.9% (by an average of 0.4 points)

Matchup must-reads: Murray's 'pinpoint' accuracy has already made an impression ... Lions face challenge of the 'unknown' in Murray, Kingsbury

8:20 p.m. ET | NBC

Matchup rating: 69.2 | Spread: NE -6 (49)

What to watch for: Tom Brady faces the Steelers' pass rush, which tied for an NFL-high 52 sacks last season, with backup center Ted Karras stepping in for David Andrews (IR, blood clots in lungs) and 2018 first-round pick Isaiah Wynn (IR as a rookie/torn Achilles) making his first career start at left tackle. How the Patriots' offensive line protects him might be the difference. -- Mike Reiss

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Bold prediction: The Steelers' improved defense will intercept Brady inside Gillette Stadium for the first time ever. Pittsburgh feels it finally has the playmakers in the back seven to match wits with Brady, who has never lost to Pittsburgh at home. -- Jeremy Fowler

Stat to know: Brady has a 86.1 Total QBR against the Steelers since the metric was first tracked in 2006, his second-best QBR against a single opponent in that span (91.8 vs. the Bears).

What to know for fantasy: In Sony Michel's past four games with at least 15 carries (playoffs included), he ran for seven touchdowns and averaged 22.3 fantasy points per game. See Week 1 rankings.

Betting nugget: Pittsburgh was 5-0 ATS as an underdog (4-1 outright) last season, including a win vs. New England. But Brady is 7-3-1 ATS against Ben Roethlisberger. Read more.

Fowler's pick: Steelers 27, Patriots 20

Reiss' pick: Patriots 27, Steelers 24

FPI prediction: NE, 65.1% (by an average of 5.6 points)

Matchup must-reads: 'Adaptable' Patriots' plan of attack in 2019? Whatever works ... Steelers come to Tom Brady chess match with versatile pieces ... Gronk: Call from Brady wouldn't tempt me back

Monday, 7:10 p.m. ET | ESPN/ESPN App

Matchup rating: 71.3 | Spread: NO -6.5 (52.5)

What to watch for: Saints players and coaches have downplayed the idea of a "hangover effect" from the NFC Championship Game, but it sure would help them move on if they could win their first season opener since 2013. -- Mike Triplett

Bold prediction: Drew Brees throws for 400 yards. The Texans' defense lost Tyrann Mathieu, Kareem Jackson and Jadeveon Clowney this offseason, and even with some new additions, Brees and Michael Thomas could take advantage of the Texans' secondary. -- Sarah Barshop

Stat to know: Brees becomes the sixth different quarterback to start a season opener at age 40 or older since 1950, joining Tom Brady, Brett Favre, Vinny Testaverde, Warren Moon and Johnny Unitas. And the Saints are 20-6 at home in prime time under Brees (2-0 last season).

What to know for fantasy: Keke Coutee is unlikely to play, and Will Fuller went over 100 receiving yards with a touchdown in all three games he played with Coutee inactive in 2018. See Week 1 rankings.

play 0:38 Ninkovich: Saints will be motivated after last season Dan Orlovsky expects Deshaun Watson to utlilize the new additions to top the Saints while Rob Ninkovich thinks New Orleans will be fired up after last year.

Betting nugget: Houston QB Deshaun Watson is 7-2 ATS as an underdog in his career (4-5 straight up). Read more.

Barshop's pick: Saints 35, Texans 20

Triplett's pick: Saints 29, Texans 23

FPI prediction: NO, 65.3% (by an average of 5.7 points)

Matchup must-reads: Tunsil, Clowney moves will define Texans ... Tales of Drew Brees in the huddle? There's really just one ... O'Brien wants the Patriot Way. His trades go against it

Monday, 10:20 p.m. ET | ESPN/ESPN App

Matchup rating: 33.9 | Spread: DEN -2.5 (42.5)

What to watch for: How emotionally drained will the Raiders be from the Antonio Brown on-again, off-again saga? The adrenaline rush from a season opener will carry the Raiders early, and an improved defense should hold the Broncos at bay. But with Brown officially released, Oakland will now move on without him. -- Paul Gutierrez

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Bold prediction: The Broncos sacked Derek Carr at least three times in three of their first four meetings but haven't sacked him more than twice in a game in any of the past five meetings. Denver will need to sack him at least four times Monday night to get a road win. -- Jeff Legwold

Stat to know: The Broncos have won seven consecutive season openers, the longest active streak in the NFL and the longest streak in franchise history. But they've also lost three straight at the Raiders and three straight games on Monday Night Football -- all to AFC West opponents.

What to know for fantasy: Denver allowed the fifth-most deep touchdown passes last season, and Tyrell Williams, likely stepping into a more prominent role than ever before, ranks fourth in yards per catch during his career (minimum 150 catches). See Week 1 rankings.

Betting nugget: Denver is 5-13 ATS in its past 18 road games and 2-8 ATS in its past 10 divisional games. Read more.

Legwold's pick: Broncos 23, Raiders 20

Gutierrez's pick: Raiders 17, Broncos 16

FPI prediction: OAK, 51.7% (by an average of 0.7 points)

Matchup must-reads: Miller's 2019 season was built on 14 words ... Is Carr entering a 'prove-it' season with the Raiders?