For the second time today, a despondent Buffalo Bills running back was taken off the field on a cart. This time it was C.J. Spiller, who landed hard on his left arm and injured his shoulder area on his first carry of the day. He toted the rock 52 yards deep into Minnesota Vikings territory before being tripped up and will be out for the rest of the game.

Earlier in the game, Fred Jackson was carted off with a groin injury and will not return. The Bills are left with Anthony Dixon as their lone healthy active running back. Frank Summers will also see some time in the backfield, as well.

Update: