Chris Collins, a Republican US congressman from New York state, has resigned ahead of his expected guilty plea in a criminal insider trading case.

Key points: Chris Collins won re-election last November, three months after he was criminally charged

Chris Collins won re-election last November, three months after he was criminally charged Mr Collins' son and another man are also scheduled to plead guilty

Mr Collins' son and another man are also scheduled to plead guilty He did not trade his own Innate stock, which lost millions of dollars in value

The criminal case relates to Australian biotechnology company Innate Immunotherapeutics Ltd, a company for which Chris Collins sat on the board and held a 16.8 per cent stake.

A senior Democratic aide speaking on condition of anonymity said Monday that the office of US House of Representatives Speaker Nancy Pelosi had received Mr Collins' letter of resignation, and that it would become effective Tuesday.

Mr Collins, 69, is scheduled to appear in the Manhattan Federal Court that day to enter his guilty plea, court records show.

Mr Collins' son, Cameron Collins, and another man, Stephen Zarsky, are also scheduled to plead guilty in the case on Thursday.

A spokesman for US Attorney Geoffrey Berman, whose office is prosecuting the case, declined to comment, as did Mauro Wolfe, a lawyer for Zarsky.

Lawyers for Chris and Cameron Collins could not immediately be reached.

Mr Collins, an early supporter of President Donald Trump, represents New York's 27th Congressional District, which includes areas surrounding Buffalo and Rochester.

He won re-election last November, three months after he was criminally charged.

Prosecutors allege that in June 2017, while attending the congressional picnic at the White House, Mr Collins learned in an email from Innate's chief executive that a clinical trial for its proposed multiple sclerosis drug MIS416 had failed.

Mr Collins immediately told the trial failure news to his son, who in turn told his fiance, Lauren Zarsky, and her parents, Dorothy and Stephen Zarsky, prosecutors allege.

Chris Collins did not trade his own Innate stock, which lost millions of dollars in value.

Prosecutors said the congressman was "virtually precluded" from trading, in part because he already faced a congressional ethics probe over Innate.

However, prosecutors said others used the insider information to avoid more than $768,000 in losses when Innate's share price plunged 92 per cent after news of the drug's failure became public.

Lauren and Dorothy Zarsky were not criminally charged but reached civil settlements with the US Securities and Exchange Commission.

Reuters