An asylum seeker allegedly denied medical care on Manus Island has suffered burns to his face and hands after locking himself in his room and setting it ablaze, according to other refugees on the island.

He is the second person on the island to set himself on fire in two weeks, amid a worsening mental health crisis.

The incident comes amid a worsening mental health crisis on the island.

The 31-year-old Indian man, who had "severe" health issues, was turned away from the island's health clinic on Friday, Manus detainee Shamindan Kanapadhi said.

He had been denied medical treatment for a long time, Mr Kanapadhi said. "Stressed" and "anguished", he self-harmed before locking himself in his room in the island's Hillside compound and setting it on fire about 1pm.