Saquon Barkley and Evan Engram could be in line for even more touches against the Bills.

Sterling Shepard has officially been ruled out for Sunday’s game with a concussion, sidelining the Giants’ new No. 1 wide receiver for the first time since 2017. Shepard had six catches for 42 yards in the season-opening loss to the Cowboys after recovering from a fractured thumb, suffered during training camp.

“He’s getting better,” coach Pat Shurmur said. “He just kind of ran out of time this week.”

While offseason acquisition Golden Tate serves the second game of his four-game suspension, Eli Manning will also be without rookie receiver Darius Slayton (hamstring). Cody Latimer, who had three receptions for 74 yards in the season-opening loss to the Cowboys, is listed as questionable with a calf injury.

“There’s a little pressure [to come back] because you don’t want to let your boys down … but your body is your temple and it’s all about longevity,” Latimer said. “I’m working hard and listening to the trainers, and I’ll see where I am. … I think I’m good to go. We’ll see before the game. We’ll see how I’m running around and moving around and make a decision then.”

The depleted receiving corps is likely to feature Russell Shepard, Bennie Fowler and T.J. Jones, who have each played at least four full seasons, and combined for 45 catches, 477 yards and four touchdowns last season. Tight end Garrett Dickerson (quad) has also been declared out.

“You play with the players you have, and anybody you put out there you expect them to make plays,” Shurmur said. “We don’t recalibrate the expectations. We expect them to go out and play well and help us win a game.”