A Sydney road will intermittently close over the weekend following a tanker crash yesterday morning.

Police have urged motorists to be aware of major traffic delays on Wentworth Avenue in Mascot, as the clean-up continues.

HAZMAT crews used foam to smother fuel after a truck overturned yesterday morning. (9NEWS)

The 46-year-old driver is believed to have lost control, causing the tanker, which was carrying 34,000 litres of fuel, to overturn on Wentworth Avenue at the intersection of Southern Cross Drive in Mascot just before 4am yesterday.

Emergency services on the scene. (9NEWS)

The tanker has been removed, however the road has been damaged from the fuel spill.

The tanker overturned on Wentworth Avenue in Mascot. (9NEWS)

HAZMAT and Fire & Rescue NSW crews are expected to continue cleaning up the area throughout the weekend.

An estimated 300 litres of fuel spilled on to the road. (9NEWS)

The driver of the tanker sustained only minor injuries, and returned a negative roadside breath test.