Hao Wang1,2, Sha Zhao1,2, Xiaoshen Zhang1,2, Keyi Jia1,2, Juan Deng1,2, Caicun Zhou1, Yayi He1



1Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai 200433, People’s Republic of China; 2Medical School, Tongji University, Shanghai 200433, People’s Republic of China



Correspondence: Caicun Zhou; Yayi He

Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, No 507 Zhengmin Road, Shanghai 200433, People’s Republic of China

Tel +86 216 511 5006; +86 216 511 5006

Email caicunzhoudr@163.com; 2250601@qq.com



Abstract: Lung cancer is one of the commonest cancers in the world. More than 70% of lung cancer patients are diagnosed with non-small cell lung cancer (NSCLC). Major histocompatibility complex class II (MHC class II), an important component in antigen presenting process, usually expresses on professional antigen presenting cells (APCs), and it can be induced by interferon-γ (IFN-γ). MHC class II can be expressed by NSCLC cells. In NSCLC patients, the expression of MHC class II can be correlated with the outcome of anti-programmed death-1 (anti-PD-1) therapy. This review summarizes MHC class II expression in NSCLC and the correlation between MHC class II and NSCLC diagnosis, prognosis and therapy.



Keywords: major histocompatibility complex class II, non-small cell lung cancer, immune therapy







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