Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Cordycepin Modulate Body Weight by Reducing Prolactin via an Adenosine A 1 Receptor

Version 1 : Received: 31 March 2018 / Approved: 3 April 2018 / Online: 3 April 2018 (07:53:24 CEST)



How to cite: Li, Y.; Li, Y.; Wang, X.; Xu, H.; Wang, C.; An, Y.; Luan, W.; Wang, X.; Li, S.; Liu, M.; Tang, X.; Yu, L. Cordycepin Modulate Body Weight by Reducing Prolactin via an Adenosine A 1 Receptor. Preprints 2018, 2018040033 (doi: 10.20944/preprints201804.0033.v1). Li, Y.; Li, Y.; Wang, X.; Xu, H.; Wang, C.; An, Y.; Luan, W.; Wang, X.; Li, S.; Liu, M.; Tang, X.; Yu, L. Cordycepin Modulate Body Weight by Reducing Prolactin via an Adenosine A1 Receptor. Preprints 2018, 2018040033 (doi: 10.20944/preprints201804.0033.v1). Copy

Cite as: Li, Y.; Li, Y.; Wang, X.; Xu, H.; Wang, C.; An, Y.; Luan, W.; Wang, X.; Li, S.; Liu, M.; Tang, X.; Yu, L. Cordycepin Modulate Body Weight by Reducing Prolactin via an Adenosine A 1 Receptor. Preprints 2018, 2018040033 (doi: 10.20944/preprints201804.0033.v1). Li, Y.; Li, Y.; Wang, X.; Xu, H.; Wang, C.; An, Y.; Luan, W.; Wang, X.; Li, S.; Liu, M.; Tang, X.; Yu, L. Cordycepin Modulate Body Weight by Reducing Prolactin via an Adenosine A1 Receptor. Preprints 2018, 2018040033 (doi: 10.20944/preprints201804.0033.v1). Copy CANCEL COPY CITATION DETAILS

Abstract

Cordycepin is an extract from the insect fungus Cordyceps. militaris, which is a traditional medicine with various biological function. In previous studies, cordycepin had been reported with excellent anti-obesity effect, but the mechanism is unclear. A large quantity of evidences showed that prolactin plays an important part in body weight regulation, hyperprolactinemia can promote appetite and accelerate fat deposition. In this study, we explored the molecular mechanism of the anti-obesity effect of cordycepin by reducing prolactin release via an adenosine A 1 receptor. In vivo, obese rats model was induced by high fat diet for 5 weeks, the serum and liver lipids coupling with serum prolactin were reduced by treatment of cordycepin, the results suggested that cordycepin is a potential drug for therapying obesity which could be related with prolactin. In vitro, cordycepin could inhibit prolactin secretion in GH 3 cells via upregulating the expression of adenosine A 1 receptor, the inhibition effect could be blocked by an antagonist of adenosine receptor A1 DPDPX, prolactin induced the upregulation of lipogenesis genes PRLR, and P-JAK2 in 3T3-L1 cells. Intriguingly, cordycepin would down-regulate the expression of prolactin receptor (PRLR). Thus, we concluded that cordycepin modulate body weight by reducing prolactin release via an adenosine A 1 receptor.

Subject Areas

cordycepin; adenosine A1 receptor; prolactin; anti-obesity

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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