Movie producer Harvey Weinstein has pleaded not guilty to charges of sexually assaulting a woman in 2006, the third criminal sex assault case brought against him, and his attorney said he expects further charges to follow.

Key points: New charges include two counts of predatory sexual assault

New charges include two counts of predatory sexual assault A lawyer for Weinstein says he will plead not guilty

A lawyer for Weinstein says he will plead not guilty More than 75 women have accused Weinstein of sexual offences

More than 70 women, mostly young actresses and other women employed in the movie business, have accused Weinstein of sexual misconduct, including rape, in a series of incidents dating back decades.

The accusations against Weinstein sparked the #MeToo movement that has seen hundreds of women publicly accuse powerful men in business, politics and entertainment of sexual harassment and abuse, lifting a shroud that had long shielded such behaviour.

Dressed in a dark suit and tie on Monday, the 66-year-old co-founder of the Miramax film studio was brought handcuffed into a Manhattan courtroom to face the latest charges.

An updated indictment, unveiled last week, alleges Weinstein performed a forcible sex act on a woman in 2006.

The new charges include two counts of predatory sexual assault, which carries a maximum sentence of life in prison upon conviction.

New York state Supreme Court Justice, James Burke, rejected prosecutors' request to order house arrest for Weinstein, allowing him to remain free on the $1 million bail that has been in effect since he pleaded not guilty in June to charges he assaulted two other women, one in 2004 and one in 2013.

Manhattan District Attorney Cyrus R Vance Jr said Weinstein is charged with "some of the most serious sexual offenses" that exist under state law.

"Mr Weinstein maintains that all of these allegations are false and he expects to be fully vindicated," Mr Weinstein's lawyer Ben Brafman said.

Seventy-five women have accused Weinstein of sexual offences. ( AP: Steven Hirsch/New York Post )

One of the other two accusers, who has not been identified publicly, told investigators Weinstein cornered her in a hotel room and raped her in 2013.

The other, former actress Lucia Evans, has gone public with her account of Weinstein forcing her to perform oral sex at his office in 2004.

More than 75 women have accused Weinstein, who was one of the most powerful men in Hollywood, of wrongdoing as allegations detailed in Pulitzer Prize-winning stories last October in The New York Times and The New Yorker magazine swelled into the #MeToo movement.

Several actresses and models accused Weinstein of criminal sexual assaults. They include film actress Rose McGowan, who said Weinstein raped her in 1997 in Utah; Sopranos actress Annabella Sciorra, who said he raped her in her New York apartment in 1992; and Norwegian actress Natassia Malthe, who said he attacked her in a London hotel room in 2008.

A former Weinstein Co production assistant, Mimi Haleyi, last October made allegations against Weinstein that align with the charges in the updated indictment.

Ms Haleyi said Weinstein forcibly performed oral sex on her in 2006 in what appeared to be a child's bedroom in his Manhattan apartment.

Neither the district attorney's office nor Ms Haleyi's attorney, Gloria Allred, would confirm if Ms Haleyi was the accuser in the new charges.

New York police said in early November they were investigating allegations by another Weinstein accuser, Boardwalk Empire actress Paz de la Huerta, who told them in October he raped her twice in 2010.

Mr Vance urged other accusers to come forward, saying the investigation continues.

"If you are a survivor of the predatory abuse with which Mr Weinstein is charged, there is still time to pursue justice," he said.

Weinstein, who produced movies including Pulp Fiction and Shakespeare in Love, has denied all allegations of non-consensual sex, with his attorney challenging the credibility of his accusers.

Sorry, this video has expired 'Delay can only benefit Mr Weinstein': Attorney urges possible victims to come forward

AP