The tiny voice crying out in the night was terrified and desperate, breaking the heart of anyone who heard it.

“Mommy, Mommy, help me!”

As a deadly inferno tore through a Brooklyn home early Saturday, a mother — unable to breach the wall of smoke and fire engulfing her eight children — also cried out.

“My kids are in there! Get them out! Get them out!” screamed Gayle Sassoon, who, burned and covered in blood, had just ­escaped out of a second-story window at the Midwood home.

She had leaped through smoke so thick “you couldn’t even see the house,” said neighbor Arnold Rosenblatt, who called 911 at 12:23 a.m. to report the fire.

“I keep thinking, if I had called a minute sooner,” he said tearfully.

It took firefighters just three minutes and 25 seconds to reach the Bedford Avenue home, where flames met them at the front door, said FDNY Commissioner Daniel Nigro. “It was too late,” he said.

Firefighters carried out the children, their soot- and ash-covered clothes in tatters, and gingerly placed their limp bodies onto stretchers and into ambulances.

Sara Sassoon, 6, was declared dead at the scene. Six more were declared dead at area hospitals.

Neighbor Nate Weber couldn’t bear to watch.

“I just turned away. I didn’t even want to look,” he said.

Just one of Sassoon’s eight children made it out alive: Tzipara, 15, who, like her mother, jumped from the second floor.

The mother suffered burns over 45 percent of her body; the daughter broke her shoulder and arm. Both were hospitalized in critical condition.

Sassoon was taken to Jacobi Medical Center in The Bronx, and Tzipara to Staten Island University Hospital North.

The dead, who all suffered a combination of burns and smoke inhalation, were Yaakob, 5; Sara, 6; Moshe, 8; Yeshua, 10; Rivkah, 11; David, 12; and Eliane, 16, authorities said.

It would have been “impossible” for the mother to save them, ­Nigro said.

“The fire came up the stairs. The mother would have had to go into the fire to get to the back bedrooms. I think she valiantly tried, although she was badly burned, to get out and get help for her children,” the shaken fire commissioner said. “It’s a tragedy for this family. It’s a tragedy for this community. It’s a tragedy for our city.”

He called it “the largest tragedy by fire that this city has had in seven years.”

In 2007, a Bronx house fire left nine children and one adult from two families dead.

In Saturday’s fire, officials believe a hot plate left on in the kitchen overnight malfunctioned, igniting the blaze. There were no smoke detectors on the first or second floors of the home, they said. The only smoke detector in the house, Nigro said, was in the basement.

Sassoon might have turned on the hot plate before sundown Friday and left it on to keep food warm, authorities said.

Observant Jews avoid turning on ovens or electrical appliances once the Sabbath begins.

Neighbors in the large Orthodox enclave described the family as “ultra-Orthodox.”

The fire moved from the kitchen to the stairwell and shot up to the second floor, where the family was sleeping.

The father, Gabriel Sassoon, who was out of town on business, has been notified of the deaths, authorities said.

The funeral will be held Sunday or Monday, a source said, adding that the victims will be buried in Israel.

Grim faced relatives visiting the survivors declined to comment. One weeping woman had to be carried inside.

Sassoon, 45, grew up in the nearly century-old, $1.5 million Bedford Avenue home, said neighbors, who added that she and her husband recently moved back to the United States from Israel, where they had lived since 1998.

“I don’t know if she makes it through this. I don’t know how she’s going to face what happened to her family,” said a friend who gave her name only as Bonnie. “I pray that she has the sanity.” Rose Insel, a longtime neighbor, spoke through tears.

“They were a beautiful family. The children used to come with their little shovels and clean my walkway without my asking them. I used to give them lollipops,” she said.

The family was active in the community, Bonnie recalled.

“They used to wash cars before Passover,” she said, calling Sassoon “a beautiful girl.”

Mayor de Blasio called the fire “an unbelievable tragedy” after touring the gutted building.

“It is unimaginable what you see in there . . . it is wiped out. Every room empty and burned and charred . . . This beautiful, vibrant family, 24 hours ago intact and now so many lost,” he said.

Responders, too, suffered.

“To find a house full of children that can’t be revived. I’m sure this will take its toll on our members,” Nigro said.

Additional reporting by Kevin Fasick, Ben Feuerherd and Georgett Roberts