Seth McFarlane cracked a joke during the 2013 Oscar Nominations about Harvey Weinstein and his apparent insatiable appetite for actresses ... and it seemed the audience was in on it.

Seth was presenting the nominations for Best Supporting Actress, and suggested the nominees were powerful enough to rebuff Weinstein's advances.

Check out the clip. The audience was super uncomfortable.

And Tina Fey wrote a joke on "30 Rock" for Jane Krakowski's character, who quipped, "I'm not afraid of anyone in show business. I turned down intercourse with Harvey Weinstein on no less than 3 occasions ... out of 5."