Gina Mather can offer 148 compelling reasons why a specialised transgender clinic is a critical service in Brisbane.

"Personally, I have had to identify 148 suicide victims. We are lucky to get one a year now," she said.

Shelley Argent, who donated $20,000 to transform the new premises into a medical clinic, cuts the ribbon at the transgender clinic's official opening.

The Australian Transgender Association Queensland president began working with the state's gender dysphoric population in 1994, when the Beattie government offered the organisation a space to establish the specialty service.

"In those days the kids had nothing, the suicide rate was at 42 per cent," she said.