The Denver Broncos vs. Indianapolis Colts game in Week 2 NFL action is one of the most anticipated games of the upcoming week. Both teams are expected to be contenders in the AFC at the end of the season, although the Broncos are widely viewed as the better team at this point in time.

Over the last few years, Peyton Manning has been at the center of attention when the Broncos and Colts faced off. Now that Manning has retired, the focus of the quarterback discussion switches to Andrew Luck. He missed most of the 2015 season with multiple injury issues but showed that he is back this week against the Detroit Lions.

Looking ahead to Sunday afternoon’s game, the Colts will have to take their game to the next level in order to knock off first-year starting quarterback Trevor Siemian and the Broncos.

Gary Kubiak knows that his offense has a lot of holes that need to be filled out as the season moves forward. He is hoping that his current roster will simply develop and fill the holes by themselves. There is no denying the talent that Denver still has, but only time will tell if they are legitimate Super Bowl contenders.

All of that being said, what five bold predictions can be made for the Broncos vs. Colts game in Week 2 of the 2016 NFL season?

[Photo by R Brent Smith/AP Images]

Trevor Siemian Throws for 350 Yards, Three Touchdowns

After seeing how poor the Colts’ secondary played against Matthew Stafford and the Lions, Denver should be very confident in their passing game. Indianapolis doesn’t have the defensive backs capable of sticking with both Demaryius Thomas and Emmanuel Sanders. Trevor Siemian should throw for 350 yards and three touchdowns, assuming the Broncos put the football in his hands early and often.

Andrew Luck Will Back Up His First Game with Another Big Performance

Indianapolis was able to breathe a sigh of relief after seeing the way that Andrew Luck played on Sunday against Detroit. He completed 31 of his 47 pass attempts for 385 yards, four touchdowns, and no interceptions. Luck will back that first game up with another big performance against a very talented Denver secondary.

C.J. Anderson Will Rack Up 150 Total Yards, Three Touchdowns

Denver opened their season with a surprising victory over the Carolina Panthers. C.J. Anderson was a big reason for his team coming out on top, carrying the football 20 times for 92 yards and a touchdown, while also catching four passes for 47 yards and a touchdown. Anderson will rack up at least 150 yards and three touchdowns this week against the porous Colts’ defense.

[Photo by Joe Mahoney/AP Images]

Antonio Cromartie Will Record His First Colts’ Interception

Even though Siemian should have a big all-around game, Antonio Cromartie will intercept him. Cromartie didn’t make much of an impact for the Colts against Detroit, but he will make his presence felt for his new team this week. Indianapolis may only make one big defensive play, but that may be enough to give them a chance to pull out a win.

Denver Will Come Away with a Hard-Fought Win

Looking at the matchup, the Broncos are a better all-around team. There is a chance that Luck and the Colts could shock the Broncos, but it will take a perfectly played game. If things go as they should, the Broncos will pull out a hard-fought win over the Colts and improve to 2-0 on the season.

Expect to see this game live up to the hype that will surround it throughout the course of the week. Both teams are battling for positioning in the AFC and there will be a little bit more on the line than a normal regular season game.

Which team do you think will end up coming out on top this week? What are your final score predictions for the Broncos vs. Colts game? Let us know your thoughts in the comment box below!

[Photo by Matt York/AP Images]