At the stately age of 108, the handsome double-width townhouse at 47-49 East 65th Street bears no resemblance to a certain tower of gilt, glitz and high security just 12 blocks away.

Yet the last time a president-elect ran a transition from his home on the east side of Manhattan, it took place in that 65th Street residence, the home of Franklin D. and Eleanor Roosevelt, on a street of understated grandeur.

“It was the Trump Tower of 1932-33,” said Harold Holzer, the director of Hunter College’s Roosevelt House Public Policy Institute, which now occupies the building.

If an estate in Hyde Park, N.Y., is landmarked in our historical consciousness as the Roosevelt residence, the family’s onetime city house, about 90 miles south, has its own claim as the incubator for the public lives of Roosevelt and Eleanor, two of the most consequential figures of 20th-century America. They lived there for most of 25 years.