VIENNA, Va. — Paul Simon says he is ready to give up making and playing music, 61 years after he started as a 13-year-old. “You’re coming towards the end,” he said in an interview this week, discussing the mysterious epiphanies that delivered some of his greatest songs, the toxic qualities of fame, and his yearning to explore questions of spirituality and neuroscience.

“Showbiz doesn’t hold any interest for me,” Mr. Simon said. “None.”

Here is why you might consider believing him.

At 74, he often needs 15 hours of sleep at a stretch. The other day, performing in Philadelphia, he looked out from the stage and was surprised to see four mountains on the horizon. When he put on his glasses, he realized the mountains were actually big white tents. His voice has held up far longer than he had any right to expect but needs frequent days of rest.

While most stars of his generation, unsurprisingly, are playing greatest hits concerts, if anything, Mr. Simon’s new album is competing with those of Drake and Beyoncé on pop music charts, and with Radiohead and Deerhoof for college radio airtime.