Melbourne strip club Showgirls Bar 20 has had its liquor licence cancelled after a push by Victoria Police.

Police challenged Showgirls Bar 20's liquor licence after "a series of licensing breaches and serious issues," police said.

Today, the Victoria Civil and Administrative Tribunal disqualified the club's licensee, Planet Platinum, from holding and managing a liquor licence.

The company's two directors were also banned from holding a liquor licence for 18 months or participating in the liquor industry.

Planet Platinum has 28 days to appeal the decision in the Supreme Court.

Melbourne Inspector Paul Ross welcomed the ruling.

“Public safety in the CBD is our number one priority and a key part of this is ensuring licensed venues are being managed properly in order to minimise the public risk associated with late night venues of this type," he said.

Showgirls Bar 20 could not be contacted for comment.