The United States and Cuba has signed an agreement authorizing up to 110 daily US commercial flights to Havana and nine other cities on the communist island.

The first flight for more than 50 years between the two countries will take off in the next six months.

On Tuesday, the deal was signed, meaning American airlines are now invited to submit applications to operate the flights.

Additionally, the Cuban government will give 'thorough consideration to future requests from the US government to increase this level of service,' US Deputy Assistant Secretary of State for Transportation Affairs Thomas Engle said.

However, it could be years before Cuban carriers can fly the same route without obtaining special permission on a case-by-case basis.

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US Secretary of Transportation Anthony R. Foxx (seated left) and Cuba's Transportation Minister Adel Yzquierdo (seated right) sign documents to approve direct routes between Cuba and the US for the first time

Ready for take-off: The first US-Cuba flight for more than 50 years will take off in six months once the deal is signed on Tuesday

Terms of the agreement allow for regular flights 'between any city in the US and any city in Cuba,' provided it is equipped with proper infrastructure for international flights, he added.

'The two governments reaffirm their commitment to strengthen their already close cooperation in aviation safety and security matters.'

The United States announced plans to resume the flights in December, on the one-year anniversary of the start of reconciliation between Washington and Havana.

Under the new arrangement, airlines in the two countries can now strike deals in such areas as code-sharing and aircraft leasing, the Cuban embassy said at the time.

However, tourist travel is still barred under the trade embargo that the United States slapped on Cuba in 1960 after Fidel Castro came to power in a revolution.

The US Treasury Department has, however, set 12 categories of authorized travel.

'Initially, the US carriers will be allowed to fly 20 scheduled frequencies per day to Havana, the largest market, and remember that the current level is zero,' Engle said.

'And also allowed to fly 10 scheduled frequencies per day to any other city in Cuba that has an airport open to international service.'

A sign shows the departure times for flights to Cuba at Miami International Airport

US Secretary of State John Kerry formally visited Cuba to re-open the American embassy in August 2015, a month after the two countries formally restored diplomatic relations

Besides Havana, flights will be allowed to Camaguey, Cayo Coco, Cayo Largo, Cienfuegos, Holguin, Manzanillo, Matanzas, Santa Clara and Santiago de Cuba.

Although the understanding formally opens the door for Cuban airlines to operate future flights into the United States, none are allowed to arrive at present.

Deputy Assistant Secretary for Aviation and International Affairs Brandon Belford said Cuban airlines will still have to obtain their own licenses from US authorities such as the Treasury Department and Office of Foreign Assets Control.

'So we do not anticipate Cuban-owned aircraft serving the US in the near future,' he said.

Later on Tuesday, the Treasury Department will invite US airlines to submit applications for allocation of the new frequencies.

Belford said 'carriers will have 15 days to submit their applications if they want to serve Havana and the other nine airports.'

All final decisions will be made in approximately half a year.

'Our expectation is that we will be in position to make a decision and make it final sometime in the summer, in terms of which carriers and which US cities will have service into Cuba,' Belford said.

Commercial flights between Cuba and the United States were cancelled 53 years ago but since the mid-1970s authorized charter flights have been allowed under certain conditions.