Cities lining the U.S. coasts should brace for a lot more flooding — from "nuisance" floods that shut down streets during high tides to deluges that take lives and wipe out infrastructure.

In a new study published Wednesday, researchers from Princeton and Rutgers universities warn that the current flooding predictions, including those widely used by policy makers, don't accurately reflect the frequency and types of floods that are likely to challenge American cities in the coming decades as global temperatures and sea levels rise.

Their research found that major coastal flooding—expected to occur only once every 100 years—will inundate coastal cities an average of 40 times more often by 2050, likely overwhelming the cities' abilities to protect themselves.

After 2050, the picture looks worse. Major flooding could slosh through the streets of New York City every other month by the end of the century, while major floods could sweep into Seattle nearly every week.

"U.S. cities and infrastructure, on the coasts — East, Gulf or West — better wake up, because there are some very large frequencies coming," said Michael Oppenheimer, a Princeton professor who has researched sea-level rise for 20 years and is a co-author of the new study, published in Environmental Research Letters. "That's assuming we don't curtail greenhouse gas emissions."

Oppenheimer and his colleagues decided to take another look at widely used assumptions, released by the Intergovernmental Panel on Climate Change in 2013, that forecast flooding frequency based on sea level rise of 1 to 3 feet by end of the century. They determined that the IPCC report's authors had approximated the frequency of flooding using the same multiplier for different flood types, which had the effect of overestimating certain flood risks in some areas and underestimating them in others.

Instead, Oppenheimer and his colleagues took their own, more recent approximations of sea level rise and combined them with current flood-return frequencies at every tide gauge in the United States. Then they calculated a more detailed risk for each location.

The idea, Oppenheimer explained, was to present a more complete prediction, tailored to each place, so that cities or areas can better prepare for floods. Some cities on the West Coast could see more extreme floods, more frequently, while on the East Coast, less extreme flooding will likely happen more often.

The ability to prepare adequately depends on being able to anticipate the frequency and severity of flooding.

"The difference between getting your basement flooded once a year in a garden-variety nuisance flood, versus getting flooded every day—that might be much more worrisome to New York than a storm like Hurricane Sandy," he said.

That said, the risk of floods occurring at the level of those caused by Sandy increases to about once a year after 2100, according to the study.

Oppenheimer says he's most concerned about chronic, but less-extreme flooding along the East Coast, including the south shore of New York's Long Island, the low country around Charleston, S.C., and south Florida, where tidal flooding already has become an everyday occurrence.

"These areas have terrain that's gently sloped," Oppenheimer said. "South Florida is really in trouble. Not only are they having a lot of nuisance flooding, but they sit on limestone, which makes it extremely difficult to build coastal defenses. These places really have to get on the ball and decide what they have to protect."

But adapting for the risk takes time, political will and money.

"This is a very threatening amount of risk we're talking about," he said. "It's a median, 40-fold increase in expected 100-year floods by 2050. That's a gigantic threat. That's only 35 years in the future. You have to start planning."

This story has been updated to clarify that the 2013 IPCC report approximated the frequency of flooding using the same multiplier for different flood types.