Story highlights US-led coalition destroyed "two artillery pieces, an anti-aircraft weapon, and damaged a tank"

Third time American warplanes have intentionally targeted Iranian proxies in Syria

(CNN) The US-led coalition announced Tuesday that it targeted pro-Syrian regime forces that entered a "well-established de-confliction zone in southern Syria."

"Despite previous warnings, pro-regime forces entered the agreed-upon de-confliction zone with a tank, artillery, anti-aircraft weapons, armed technical vehicles and more than 60 soldiers posing a threat to coalition and partner forces based at the At Tanf Garrison," a coalition statement said.

After several warnings over the de-confliction channel, the coalition destroyed "two artillery pieces, an anti-aircraft weapon, and damaged a tank."

Al-Tanf on the Syrian-Jordanian border, which Russian warplanes bombed a year ago in two successive airstrikes, is manned by US and British Special Forces that are advising an anti-ISIS Syrian rebel group known as Maghawir al-Thawra, or the Commandos of the Revolution.

Pro-Assad Shia militias backed by Iran have historically operated in that area.

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