Champions League last 16 stats: Are Chelsea Lionel Messi's nemesis?

Didier Drogba consoles Lionel Messi - who hit the bar with a penalty - after Chelsea's Champions League semi-final aggregate win over Barcelona in 2012

The five Premier League sides now know their Champions League knockout fate but how have they fared previously against their last-16 opponents?

Here, Opta pick out the best head-to-head statistics - including a surprising Lionel Messi fact to boost Chelsea...

Juventus v Tottenham

This will be the first meeting between Juventus and Tottenham in European competition.

Juventus have been eliminated in each of their last five knockout ties with English teams in Europe.

Tottenham will be facing Italian opposition for the second time in the Champions League Last 16; progressing past Milan (1-0 over two legs) in 2011.

Tottenham will face Juventus in the last-16 of the Champions League

Basel v Manchester City

FC Basel have lost just four of their 14 Champions League games against English sides (W5 D5 L4).

This will be Manchester City's first ever match against Swiss opposition in European competition.

The Citizens have progressed in just one of their previous four Last 16 ties in the Champions League (v Dynamo Kyiv in 2015-16).

Manchester City will face Swiss side Basel for the first time

Porto v Liverpool

Liverpool's record against Porto P W D L GF GA 4 2 2 0 7 2

Liverpool will be facing FC Porto for the first time in the Champions League since the 2007-08 group stages. Liverpool won 4-1 at home and drew 1-1 away.

The other meeting between these two sides came in the UEFA Cup quarter-finals in 2001, Liverpool winning 2-0 over two legs and eventually winning the competition.

Liverpool have won just two of their last 10 European games against Portuguese opposition (W2 D4 L4).

Mohamed Salah's Liverpool topped their group in style but have a poor recent record against Portugese opposition

Sevilla v Man Utd

This will be the first meeting between Sevilla and Manchester United in European competition.

Man Utd have won just two of their last 10 Champions League matches against Spanish sides (W2 D5 L3).

The Red Devils have lost three of their last four CL knockout games (including final) versus Spanish teams.

Manchester United will face Spanish outfit Sevilla

Chelsea v Barcelona

Chelsea's record against Barcelona P W D L GF GA 15 5 5 5 20 25

Barcelona have progressed from six of their last seven Champions League knockout ties against English opposition (excluding final) - the exception was against Chelsea in the semi-final in 2011/12.

Chelsea will meet Barcelona for the 6th time in the Champions League knockout stages; only Bayern Munich and Real Madrid have met on more occasions (8).

Lionel Messi has faced Chelsea eight times without scoring a single goal from 29 shots; his worst record against a single club during his career.