A US teenager has been arrested after he allegedly spiked his unsuspecting co-workers with LSD.

Police were called to the rental car company where the 19-year-old worked on Monday, after workers reported they were feeling dizzy and shaky.

The Missouri teen reportedly told authorities he did it because his co-workers had "negative energy."

He admitted to slipping the potent hallucinogen into the water bottles of two co-workers, and the coffee cup of a third.

Two employees were taken to hospital to be checked, but both were fine once the LSD wore off, reports KLTV.

No charges have been laid, as tests are still being completed on the water bottles.

The accused man could face charges of possession of a controlled substance and second-degree assault if the water bottles come back positive for the drug.

Newshub.