A man is in hospital after allegedly being involved in a fight with home owners as he attempted to break into their Sydney eastern suburbs property.

Police said the man, aged in his 20s, attempted to enter a home in Prothero Place in Pagewood when he was confronted by the occupants of the house.

A fight then broke out between two men just before 2:00pm on Saturday.

Police said the intruder fell unconscious during the fight outside the home and needed treatment from NSW Ambulance paramedics.

The alleged intruder was in a serious but stable condition when he was taken to St Vincent's Hospital.

The man in the home suffered a minor injury to his hand, police said in a statement.

It is believed the intruder was not known to the people inside the home.

Investigations into the incident are continuing.