Sen. Elizabeth Warren Elizabeth WarrenHarris joins women's voter mobilization event also featuring Pelosi, Gloria Steinem, Jane Fonda Judd Gregg: The Kamala threat — the Californiaization of America GOP set to release controversial Biden report MORE (D-Mass.) is warning President-elect Donald Trump Donald John TrumpOmar fires back at Trump over rally remarks: 'This is my country' Pelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Trump mocks Biden appearance, mask use ahead of first debate MORE to reverse his decision to nominate Sen. Jeff Sessions Jefferson (Jeff) Beauregard SessionsGOP set to release controversial Biden report Trump's policies on refugees are as simple as ABCs Ocasio-Cortez, Velázquez call for convention to decide Puerto Rico status MORE (R-Ala.) to be attorney general or else the Senate may reject him a second time.

"I urge President-elect Trump to reverse his apparent decision to nominate Senator Sessions to be Attorney General of the United States," Warren said in a statement Friday. "If he refuses, then it will fall to the Senate to exercise fundamental moral leadership for our nation and all of its people."

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She noted that the Senate blocked Sessions from a federal judgeship in 1986 over racism accusations, which he denied, and added that Republicans should support blocking him from serving in the administration.

"That Senate affirmed that there can be no compromise with racism; no negotiation with hate," Warren said. "Today, a new Republican Senate must decide whether self-interest and political cowardice will prevent them from once again doing what is right."

Republicans on the Judiciary Committee and Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellPelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Senate GOP aims to confirm Trump court pick by Oct. 29: report Trump argues full Supreme Court needed to settle potential election disputes MORE (R-Ky.) have rallied around Trump's decision to make Sessions the country's top law enforcement official.

Democrats, however, have pledged that Sessions will face a "thorough" vetting process while voicing skepticism that the Alabama senator would provide legal protections to all Americans equally.

Sen. Cory Booker (D-N.J.) said separately he is "concerned that he possesses ideologies that are in conflict with basic tenants of the Justice Department’s mission."

Incoming Senate Democratic Leader Charles Schumer Chuck SchumerSenate Democrats introduce legislation to probe politicization of pandemic response Schumer interrupted during live briefing by heckler: 'Stop lying to the people' Jacobin editor: Primarying Schumer would force him to fight Trump's SCOTUS nominee MORE (D-N.Y.) said he has concerns about what Sessions would do to the Justice Department's Civil Rights Division.

Sessions will only need a simple majority vote because of Democrats' decision to use the "nuclear option" in 2013. The GOP is expected to hold 52 seats in the Senate after next month's Louisiana Senate runoff election.