The Victorian father who died after a week-long battle with influenza is believed to have had the flu shot.

James Day, 43, from Traralgon in the Gippsland region, spent a week in hospital with influenza before he died on Sunday from "major" complications.

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In a Facebook post a week earlier, his wife Jennifer said the otherwise healthy hospital worker was fighting for his life.

"James has been battling Influenza the last eight days. Unfortunately it has hit him and his body quite hard and last night he was admitted to the Alfred ICU. He is very sick," she wrote.

James Day and his wife Jennifer on their wedding day. Credit: GoFundMe

Day and his wife both worked at Latrobe Regional Hospital.

Chief Executive Peter Craighead said the death had devastated staff.

“James was with us for a short time but had connected with so many of our staff who are understandably shocked that his life was taken in this way," Craighead said in a statement.

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"Our nurses who work with his wife Jennifer are equally upset, knowing how challenging a time this has been for her and their young son."

Acting chief health officer Angie Bone said Day's death was a harsh reminder that even healthy people who are vaccinated can succumb to the flu.

A father has died after a battle with a strain of the flu leaving behind his wife and young son. Credit: GoFundMe

"It really highlights the importance of all of us taking basic protective measures," Bone told reporters.

"These are things like ensuring that you had your flu vaccination for this season, washing your hands, using cough hygiene, so coughing into your elbow and not spreading droplets that might be infected and if you are unwell staying at home and seeking medical attention."

Chevron Right Icon 'It really highlights the importance of all of us taking basic protective measures.'

Bone said the flu virus could live on a surface for 48 hours.

More than 20,000 people have been diagnosed with the flu in Victoria since the season started in January, months earlier than usual.

It is the first time Victoria has had one flu season immediately follow another, Bone said.

"It's difficult to know why it started so early this year. One suggestion is that the flu season 2018 wasn't very severe at all, it was really quite mild, so that perhaps our levels (of) immunity in the population are lower, which meant that it started earlier," she said.

A GoFundMe page has raised more than $8000 to assist Day's wife and young son.

- With AAP

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