Antidepressants can raise the risk of suicide, the biggest ever review has found, as pharmaceutical companies were accused of failing to report side-effects and even deaths linked to the drugs.

An analysis of 70 trials of the most common antidepressants - involving more than 18,000 people - found they doubled the risk of suicide and aggressive behaviour in under 18s.

Although a similarly stark link was not seen in adults, the authors said misreporting of trial data could have led to a ‘serious under-estimation of the harms.’