Transcriptionally inactive regions in the eukaryotic DNA consist of tight DNA-protein structures. Only the transcriptionally active chromosomal regions ones show looser DNA-protein structures. Hence, it helps in making the DNA sensitive to the activity of DNase I (This enzyme digests the DNA). The chromosomal regions such as the promoters show hypersensitivity to the DNase- I activity since they consist of looser DNA-protein structures. The non-expressed genes show core promoters having the chromatin structure repressive to the process of transcription. The only way to activate the process of transcription involves chromatin remodeling. It greatly involves binding of the activators to the enhancers. Without a bond between the activator and enhancer, it is not possible to carry out the remodeling smoothly. The activators mainly help in recruiting the chromatin remodeling complexes. They either involve acetylation of nucleosomes, thereby loosening their association with the DNA, or allow restructuring of the nucleosomes, thereby allowing the access of the promoters to the transcription machinery.