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More than 70 immigrants were pepper-sprayed at an Immigration and Customs Enforcement detention center on Wednesday, according to a government document obtained by BuzzFeed News — the fourth known use-of-force incident this week at ICE facilities as fear and anxiety spreads among detainees over COVID-19.

Since Monday, guards at three ICE detention facilities in Louisiana and Texas — LaSalle ICE Processing Center, Pine Prairie ICE Processing Center, and South Texas ICE Processing Center — have used force to quell inmate protests.

Advocates and attorneys have reported that ICE detainees have had limited access to soap and are worried that the coronavirus, which causes COVID-19, could spread undetected, leaving those with underlying medical conditions and the elderly at risk. ICE officials have said they are constantly monitoring detainees and staying in close touch with medical experts on the potential spread of the disease in detention facilities. ICE has so far confirmed that one of the 38,000 detainees in its custody has tested positive for the coronavirus in New Jersey.

“They are freaking out about it,” said Alexandra Seo, whose mother is at the LaSalle ICE Processing Center in Jena, Louisiana. “She is saying ‘help her’ she is begging for help.”

On Wednesday, ICE medical officials, along with members from the private prison company running the facility, GeoGroup, held a meeting about COVID-19 at LaSalle, according to the government document obtained by BuzzFeed News. It was then that a group of detainees began protesting and ignored the guards’ orders. Soon after, four detainees rushed an exit door. The guards decided to use pepper spray to keep the other 75 detainees in the area, according to the document.

ICE spokesperson Bryan Cox confirmed the incident, saying detainees “refused to comply with directives from facility staff and four attempted to force their way out of the housing area.”

On Monday, officials used “pepper balls” on 23 detainees at the LaSalle facility following a protest, according to a separate document. At Pine Prairie, ICE said a group of detainees were pepper-sprayed on Tuesday after becoming “physically combative” in the recreation area. At the South Texas ICE Processing Center, 60 detainees started a demonstration as they demanded to be released from the jail and refused to comply with orders, according to ICE.

“The detainees told facility staff they would continue their protest until they were released from custody; however, those actions compromised security protocols at the facility,” said Adelina Pruneda, an agency spokesperson. “After detainees refused to comply with numerous commands given by contract staff, the contract staff initiated an immediate ‘use of force’ by disbursing oleoresin capsicum, commonly referred to as OC Spray.”