The manager of a hotel near Newark Liberty International Airport that relies on tourists from China estimated the loss from the coronavirus outbreak at “well over $100,000 and climbing.”

A company that arranges Chinese-language bus tours of the sights in Manhattan is dealing with as many as 300 cancellations from Chinese tourists who cannot come to New York this week.

The owner of a travel agency in Queens who had booked trips for 200 Chinese tourists this week and next has already thought about when he might have to lay off two of his five employees.

With health officials scrambling to deal with an outbreak that is spreading around the world, tour operators and travel agents in the New York area are bracing for the economic pain that will come with empty rooms in hotels and empty seats on tour buses.