Coffee ingredient chlorogenic acid blocks insulin's pro-aging effect

Study

Chinese biochemists, affiliated with the Kunming Institute of Botany, experimented with the model organism Caenorhabditis elegans, a little roundworm. The reserachers added different concentrations of chlorogenic acid to the medium in which the worms lived.

Results

Supplementation with chlorogenic acid prolonged the life of the worms. Remarkably, the lowest dose - 50 micromol - seemed to work best. 'More' in this case is therefore not synonymous with 'better'.













On the bottom left, you see that chlorogenic acid inhibited the action of the insulin-activated AKT signaling molecule. Below right you can see that the life-prolonging effect of chlorogenic acid was not present in a Caenorhabditis elegans variant with a deviant daf-16 gene.





Conclusion

"We found that chlorogenic acid, consistent with its effect on agerelated disease, could extend the lifespan of Caenorhabditis elegans via insulin/ insulin-like signaling pathway", the researchers summarize.

"Given the wide usage and the beneficial effect of chlorogenic acid for human health, the lifespan extension effect of chlorogenic acid in mammals, including humans, is worth to be further investigated. Our findings may serve as a starting point for developing the possibility of nutraceutical or pharmaceutical interventions in the aging process."

Source:

J Gerontol A Biol Sci Med Sci. 2017 Apr 1;72(4):464-472.

More:

Ginger, the life-extensionist's spice 16.07.2018

Omega-3 fatty acids extend your life span 04.01.2018

Longevity-factor Q10 18.05.2017



Archives:

Insulin & Glucose Metabolism

Chlorogenic Acid

Longevity

