A 27-year-old man was shot dead inside a packed Cincinnati nightclub early Sunday morning after gunfire erupted inside the crowded venue leaving another 15 people injured.

Cincinnati police Chief Eliot Isaac said during a news conference that 27-year-old O'Bryan Spikes, a father-of-three, died in the horrific shooting at the Cameo club on Kellogg Avenue in the city.

Isaac said the shooting, which is not terrorism related, was reported just after 1am as police believe multiple shots were fired from more than one firearm. No arrests have been made related to the incident.

'The conflict is believed to have begun between specific groups or individuals earlier in the day, escalating and ultimately leading to this tragedy occurring at the nightclub,' Cincinnati City Manager Harry Black said.

Of the injured, two people are in critical condition, three people are in serious condition and four people are in stable condition all at the University of Cincinnati Medical Center, WLWT reported.

Scroll down for video

O'Bryan Spikes (above), 27, died in the horrific shooting that left another 15 people injured at the Cameo club on Kellogg Avenue in the city early Sunday morning

Tributes to Spikes (above) are being posted by friends and family to his social media, many of whom are in shock over his death. He was a father to three young children

Cincinnati police Chief Eliot Isaac (above) said during a news conference the shooting, which is not terrorism related, was reported just after 1am as police believe multiple shots were fired from more than one firearm

Cincinnati City Manager Harry Black said: 'The conflict is believed to have begun between specific groups or individuals earlier in the day, escalating and ultimately leading to this tragedy occurring at the nightclub' (scene above)

No arrests have been made related to the incident as police are still searching for suspects (scene above)

Of the shooting, Cincinnati police Capt. Kim Williams said there was 'just a lot of chaos, obviously, when shots were fired. Saturday night, it is a very young crowd.' (scene above)

Two victims were treated and released from Bethesda North Hospital, while two more are in stable condition at Christ Hospital.

One victim was treated and released from Mercy Anderson and another was also treated and released from Mercy West.

No details have been released on the types of injuries or the identities of the shooting victims.

It's unclear how firearms were allowed inside the venue, as Issac said that every person inside the club should have been checked by security to see if they were carrying weapons.

Several officers were working security detail at the club and performed first aid and tried to revive Spikes.

Earlier Sunday morning, Assistant Police Chief Paul Neudigate said: 'We are in the middle of a very horrific situation that occurred at the nightclub with multiple victims.

'It's going to be a long night for our homicide units to investigate.'

Capt. Kim Williams said there was 'just a lot of chaos, obviously, when shots were fired.

'Saturday night, it is a very young crowd. We have had incidents here in the past, but this is by far the worst.'

She added: 'Saturday night, it is a very young crowd. We have had incidents here in the past, but this is by far the worst.' (scene above)

Of the injured, two people are in critical condition, three people are in serious condition and four people are in stable condition all at the University of Cincinnati Medical Center (scene above)

Two victims were treated and released from Bethesda North Hospital, while two more are in stable condition at Christ Hospital. One victim was treated and released from Mercy Anderson and another was also treated and released from Mercy West (scene above)

Several officers were working security detail at the club and performed first aid and tried to revive the person who died, Williams said. (scene above)

In addition to searching for the shooter or shooters, police are also trying to track down witnesses who fled the scene when the bloody attack happened at the venue where hundreds had gathered for what was promoted online by the nightclub to be a 'grown and sexy night.'

'The biggest problem when you have a large crowd like this and the shots ring out, a lot of the witnesses disappear,' Williams said.

'...everyone that we can identify is being interviewed,' Neudigate added.

Authorities were asking anyone with information to come forward. Williams said investigators are checking to see if surveillance cameras were working.

Ohio Gov. John Kasich said during a CNN interview Sunday morning that there's not a lot of information in regards to the incident.

Kasich said the mayor of Cincinnati will be on the scene for most of the day before questioning 'where is it safe to go?'

Authorities were asking anyone with information to come forward. Williams said investigators are checking to see if surveillance cameras were working. (scene above)

Ohio Gov. John Kasich sent a tweet offering prayers to the victims and families of those involved in the incident. (scene above)

Ohio Gov. @JohnKasich on the Cincinnati nightclub shooting: “Where is it safe to go?” https://t.co/xDcGUwtf2L — CNN Politics (@CNNPolitics) March 26, 2017

Earlier in the morning, Kasich sent a tweet offering prayers to the victims and families of those involved in the incident.

He wrote: 'Saddened to learn about last night's shooting in Cincinnati. Our prayers are with the victims and families of all of those involved. (1/2)

'I've instructed our administration to offer any assistance the state can provide. (2/2)'

This is not the first shooting at Cameo Club. Back in 2015, three men were left injured after being shot outside the venue.

Two of the victims were hurt during a 'melee' involving a dozen people.

Moments later someone involved in the fight fired up to four shots striking a 21-year-old in the foot.

Cameo Club describes Saturday night as a 'grown up and sexy night' for partygoers who are over the age of 21. Police are pictured at the scene

In 2015 three men were left injured after being shot outside the nightclub, pictured

The area where Cameo club is located is mostly industrial but also home to several nightclubs with a smattering of homes.

It's also fairly desolate at night, with the exception of the nightlife scene and 24-hour gas stations.

The road where the club sits was easily cordoned off by a single police cruiser and officer at either end.

The incident comes less than a year after a gunman slaughtered 49 innocent revelers in the deadliest mass shooting in US history.

Omar Mateen, 29, stormed into the Pulse nightclub in Florida before opening fire.

ISIS claimed responsibility for the attack which left dozens of victims injured as well as the dead.

Shortly before the attack, Mateen, who was born in New York to Afghan parents, called 911 and pledged allegiance to terror leader Abu Bakr al-Baghdadi, law enforcement officials said at the time.