Kevin De Bruyne is poised to make his Manchester City along with Nicolas Otamendi after their respective summer transfer, but the Premier League leaders will be without influential midfielder David Silva for the trip to second-placed Crystal Palace this Saturday.

Silva has been ruled out of the Selhurst Park encounter by City manager Manuel Pellegrini after suffering an ankle injury during Spain’s 1-0 Euro 2016 qualifier victory over Macedonia in midweek.

With the 29-year-old ruled out, it gives Pellegrini a simple decision should he wish to hand De Bruyne his first start since completing his £55m move from Wolfsburg last month. De Bruyne has been tipped to replace Jesus Navas on the right, but with Silva absent the Belgium international looks certain to be deployed in a central role behind striker Sergio Aguero.

Manchester City injury and suspensions Show all 5 1 /5 Manchester City injury and suspensions Manchester City injury and suspensions Sergio Aguero (striker) Injured his hamstring during the international break and is expected to miss six weeks, making a return likely in mid-late November Manchester City injury and suspensions David Silva (midfield) The midfielder picked up a problem during the international break and has not played for City since, he will miss the Manchester derby but is expected to return by the end of the month. Getty Images Manchester City injury and suspensions Fabian Delph (midfield) Delph lasted just nine seconds when starting for England before suffering a recurrence of the hamstring injury that he picked up in the season-opener against West Brom. Manuel Pellegrini has said he will be out for around six weeks, and could be back in action in late October. PA Manchester City injury and suspensions Gael Clichy (defender) Clichy was another to pick up an early knock in pre-season after suffering a knee injury. Will spend at least another month on the sidelines and is due back in late October Getty Images Manchester City injury and suspensions Samir Nasri (midfielder) Played against Bournemouth but picked up a hamstring injury that kept him out of the Sevilla match and will make him miss the Manchester derby. His return is not yet known. Reuters

While the blow will keep him out of the weekend’s action, Silva is expected to be fit for Tuesday’s Champions League opener with Juventus.

Another to be ruled out through injury is England midfielder Fabian Delph after he suffered a recurrence of the hamstring injury that has hampered the start to his City career.

Delph picked up the original injury in the opening game of the season against West Brom, but having returned as a substitute in the 2-0 victory over Watford a fortnight ago, the midfielder broke down just nine seconds into England’s midweek win over Switzerland and has been ruled out by Pellegrini for around six weeks.

Full-backs Pablo Zabaleta and Gael Clichy remain sidelined with ankle and knee injuries respectively, but Bacary Sagna has passed a late fitness test after he returned from France duty with an ankle knock of his own.