Former Vice President Joe Biden Joe BidenMomentum growing among Republicans for Supreme Court vote before Election Day Trump expects to nominate woman to replace Ginsburg next week Video of Lindsey Graham arguing against nominating a Supreme Court justice in an election year goes viral MORE said he would never have agreed to replace former Democratic presidential nominee Hillary Clinton Hillary Diane Rodham ClintonJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Momentum growing among Republicans for Supreme Court vote before Election Day Warning signs flash for Lindsey Graham in South Carolina MORE during the 2016 race.

During an interview on NBC's "Today," Biden was asked about former interim Democratic National Committee chairwoman Donna Brazile's comments that she considered replacing Clinton with Biden as the party's presidential nominee.

"Did anyone ever discuss that possibility with you? Would you have taken the nomination under those circumstances?" Biden was asked during the interview.

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Biden said the first time he heard about that possibility was in Brazile's book.

"I would never have taken it," Biden said. "I was for Hillary. I did 83 campaign events for Hillary. I think I can say I did more events and worked harder for Hillary, as hard for Hillary, as anyone else."

Biden said Clinton would have been a "first-rate president."

He said at that point, he had already made the judgment that he was "not prepared" to run for president.

"I was not ready, in terms of my family, so no, I would never have done that," he said.

In her book, “Hacks: The Inside Story of the Break-ins and Breakdowns That Put Donald Trump Donald John TrumpUS reimposes UN sanctions on Iran amid increasing tensions Jeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Trump supporters chant 'Fill that seat' at North Carolina rally MORE in the White House,” Brazile described concerns over Clinton's health during the campaign.

She wrote she considered removing Clinton and replacing her with Biden.

She ultimately decided against the shake-up, saying she felt she couldn't upend the campaign of the first woman presidential nominee of a major political party.

“I thought of Hillary, and all the women in the country who were so proud of and excited about her," she wrote. "I could not do this to them.”

In an interview earlier this month, Brazile said she didn't tell Biden he was her pick to replace Clinton if the party needed a "plan B."