An Avengers fan holds tickets at the TCL Chinese Theatre in Hollywood to attend the opening screening of "Avengers: Endgame" in Los Angeles, California, U.S., April 25, 2019.

No other film showing at the box office this weekend made more than $10 million.

The previous record holder was "Avengers: Age of Ultron" with 82.1% of all ticket sales and "Avengers: Infinity War" with 81.9%, according to data from Comscore.

The Disney and Marvel Studios film represented around 90% of all domestic ticket sales, the highest opening weekend box office dominance in the history of cinema.

"Avengers: Endgame" made history this weekend, hauling in a whopping $350 million in the U.S. during its debut.

"In the wake of 'Avengers: Endgame,' outside of Disney, rival studios' films in the top 10 dropped an average of 68% this weekend," Exhibitor Relations reported via Twitter Sunday.

Notably, "The Curse of La Llorona," which debuted last week, only earned around $7.5 million this weekend, a 72% drop in ticket sales. Traditionally, films will drop around 50% between their first and second week.

With all the buzz about "Endgame" headed into its opening weekend, it's not surprising that it fared so well at the box office. What was so shocking was that no film has ever come close to reaching $300 million, let alone $350 million, in its opening weekend.

Not only that, but globally "Endgame" hauled in more than $1.2 billion, becoming the fastest film to reach the billion dollar benchmark.

"These numbers were unthinkable a week ago," Paul Dergarabedian, senior analyst at Comscore, said. "It's unprecedented."

Ahead of its release, the film had more than 8,000 sold-out showings on Fandango, and theater owners were still adding more screens, some at odd hours, to meet the demand in the days leading up to the film's debut.

"We've never seen a movie with so many showtimes for an opening weekend and thousands of those showtimes sold out," Matthew Bakal, cofounder of Atom Tickets, said. "'Avengers: Endgame' is currently taking up nearly 70% of all showtimes on Atom because theaters added more screenings and extended hours to manage the demand of opening weekend."