Many of the same shadowy organizations that pay people to promote male erectile dysfunction drugs via spam and hacked websites recently have enjoyed a surge in demand for medicines used to fight malaria, lupus and arthritis, thanks largely to unfounded suggestions that these therapies can help combat the COVID-19 pandemic.

A review of the sales figures from some of the top pharmacy affiliate programs suggests sales of drugs containing hydroxychloroquine rivaled that of their primary product — generic Viagra and Cialis — and that this as-yet-unproven Coronavirus treatment accounted for as much as 25 to 30 percent of all sales over the past month.

KrebsOnSecurity reviewed a number of the most popular online pharmacy enterprises, in part by turning to some of the same accounts at these invite-only affiliate programs I relied upon for researching my 2014 book, Spam Nation: The Inside Story of Organized Cybercrime, from Global Epidemic to Your Front Door.

Many of these affiliate programs — going by names such as EvaPharmacy, Rx-Partners and Mailien/Alientarget — have been around for more than a decade, and were major, early catalysts for the creation of large-scale botnets and malicious software designed to enslave computers for the sending of junk email.

Their products do not require a prescription, are largely sourced directly from pharmaceutical production facilities in India and China, and are shipped via international parcel post to customers around the world.

In mid-March, two influential figures — President Trump and Tesla CEO Elon Musk — began suggesting that hydroxychloroquine should be more strongly considered as a treatment for COVID-19.

The pharmacy affiliate programs immediately took notice of a major moneymaking opportunity, noting that keyword searches for terms related to chloroquine suddenly were many times more popular than for the other mainstays of their business.

“Everyone is hysterical,” wrote one member of the Russian language affiliate forum gofuckbiz[.]com on Mar. 17. “Time to make extra money. Do any [pharmacy affiliate] programs sell drugs for Coronavirus or flu?”

The larger affiliate programs quickly pounced on the opportunity, which turned out to be a major — albeit short-lived — moneymaker. Below is a screenshot of the overall product sales statistics for the previous 30 days from all affiliates of PharmCash. As we can see, Aralen — a chloroquine drug used to treat and prevent malaria — was the third biggest seller behind Viagra and Cialis.

In mid-March, the affiliate program Rx-Partners saw a huge spike in demand for Aralen and other drugs containing chloroquine phosphate, and began encouraging affiliates to promote a new set of product teasers targeting people anxiously seeking remedies for COVID-19.

Their main promotion page — still online at about-coronavirus2019[.]com — touts the potential of Aralen, generic hydroxychloroquine, and generic Kaletra/Lopinavir, a drug used to treat HIV/AIDS.

On Mar. 18, a manager for Rx-Partners said that like PharmCash, drugs which included chloroquine phosphate had already risen to the top of sales for non-erectile dysfunction drugs across the program.

But the boost in sales from the global chloroquine frenzy would be short-lived. Demand for chloroquine phosphate became so acute worldwide that India — the world’s largest producer of hydroxychloroquine — announced it would ban exports of the drug. On Mar. 25, India also began shutting down its major international shipping ports, leaving the pharmacy affiliate programs scrambling to source their products from other countries.

India recently said it would resume exports of the drug, and judging from recent posts at the aforementioned affiliate site gofuckbiz[.]com, denizens of various pharmacy affiliate programs are anxiously awaiting news of exactly when shipments of chloroquine drugs will continue.

“As soon as India opens and starts mail, then we will start everything, so get ready,” wrote one of Rx-Partners’ senior recruiters. “I am sure that there will still be demand for pills.”

Global demand for these pills, combined with India’s recent ban on exports, have conspired to create shortages of the drug for patients who rely on it to treat chronic autoimmune diseases, including lupus and rheumatoid arthritis.

While hydroxychloroquine has long been considered a relatively safe drug, some people have been so anxious to secure their own stash of the drug that they’ve turned to unorthodox sources.

On March 19, Fox News ran a story about how demand for hydroxychloroquine had driven up prices on eBay for bottles of chloroquine phosphate designed for removing parasites from fish tanks. A week later, an Arizona man died and his wife was hospitalized after the couple ingested one such fish tank product in hopes of girding their immune systems against the Coronavirus.

Despite many claims that hydroxychloroquine can be effective at fighting COVID-19, there is little real data showing how it benefits patients stricken with the disease. The largest test of the drug’s efficacy against Coronavirus showed no benefit in a large analysis of its use in U.S. veterans hospitals. On the contrary, there were more deaths among those given hydroxychloroquine versus standard care, researchers reported.

In an advisory released today, the U.S. Food and Drug Administration (FDA) cautioned against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems.

Tags: Alientarget, Aralen, chloroquine phosphate, Cialis, Coronavirus, COVID-19, Elon Musk, EvaPharmacy, gofuckbiz, hydroxychloroquine, Malien, pharmcash, President Trump, RX-Partners, Spam Nation, Viagra