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A doctor has been killed after being shot by a former patient at a hospital in Berlin.

The attacker then turned the gun on himself, police said.

Shots were heard at a university clinic in Steglitz, a southwestern district of the German capital, at around 11am.

German newspaper Bild said on Twitter that a doctor at the Benjamin Franklin University Hospital had been critically injured and the gunman had killed himself.

Police in Berlin confirmed that he sadly passed away soon after.

There's no sign the attack is terror-related. The situation is now under control and there is no sign of other injured people or more offenders, officers added.

A witness told Tagesspiegel: "I was stood in front of the main entrance, when suddenly it was approached by a large number of police.

"Heavily-armed officers have secured all entrances. Also, the SEC (special police task force) is at the scene."

(Image: REUTERS)

(Image: REUTERS)

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Employees and visitors were "led calmly out of the building," they added.

People who came from the clinic had reported shots on the fourth floor of the hospital.

The staff were asked by the hospital management to stay in their rooms and lock the doors.

A spokeswoman for the Benjamin Franklin campus of the Charite university hospital had no immediate comment.

(Image: REUTERS)

The incident follows four other attacks in Germany since July 18 that left 10 people dead and dozens injured.

An ISIS suicide bomber injured 15 people when he blew himself up outside a music festival in in Ansbach.

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The bomber, who has been named as Mohammad Daleel, killed himself and injured 12 others, three of them seriously, when he detonated an explosive device near a bar in central Ansbach on Sunday evening.

On Friday evening gunman Ali Sonboly, 18, opened fire near a busy shopping mall and McDonald's restaurant in Munich, killing nine people.

(Image: Bild)

Part of the initial findings from the Bavarian Criminal Police Office found that the 18-year-old German-Iranian could have been plotting his attack for a year after visiting the site of a previous school shooting.

A week ago crazed attacker Muhammad Riyad hacked and slashed at dozens of terrified passengers on board a train close to Wurzburg.

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The 17-year-old savage, who ISIS claim was one of their terrorists, injured 18 people in the axe and knife attack - with two men from Hong Kong and a local woman left fighting for their lives.

According to reports, Riyad addresses his father in the journal and asks him to pray that he could take revenge "on the infidels" and "get to Heaven".