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Cuban state run TV reported the Boeing 737 crashed shortly after takeoff from Jose Marti International Airport in Havana.

Pictures from the scene showed huge plumes of black smoke visible form the terminal.

And photos of crash scene show the aircraft completely broken apart as emergency services search for survivors.

Cuban president Miguel Diaz-Canel said there is a “high number of victims".

There have been reports of 104 passengers and nine crew on the plane which went down in a “fireball”.

Ambulances and firefighters rushed to the scene and have been caught helping victims from the wreckage.

"A column of black smoke rose up in the sky," said Ana Gonzalez, a nearby resident.

Flight tracking websites indicated the flight was CU972, departing Havana at 11am local time.

It was scheduled to land just 80 minutes later in a domestic flight.

(Image: GETTY) (Image: GETTY)

The aircraft was possibly leased from a small Mexican airline called Damojh, state media said.

Video from the scene shows teams of paramedics and firefighters working in the smoking wreck.

The plane crashed between the locality of Boyeros and the village of Santiago de La Vegas.

Military officials have said there only appears to be three survivors – and all are in critical condition.

(Image: GETTY) (Image: GETTY)

Jamaica Prime Minister Andrew Holness posted on Twitter: "Our thoughts and prayers go out to our Caribbean neighbours in Cuba after a Boeing 737 passenger jet crashed this afternoon at Havana's Jose Marti International Airport in Cuba.

"We pray for the safety of the passengers and flight crew."

(Image: GOOGLE MAPS)

A Cubana de Aviacion aircraft was involved in a crash back 2005 when it suffered a mechanical failure during take-off in Caracas.

It lost a wing and an engine before crashing off the runway – wounding six passengers.