Drug safety and regulation in Australia are under threat from US President Donald Trump, says leading Australian doctor John Rasko.

Professor Rasko, with two international colleagues from Japan and Canada, has penned a comment article in the journal Nature published on Thursday calling for the US Food and Drug Administration to continue regulation of pharmaceuticals for both efficacy and safety.

In January, Mr Trump told pharmaceutical industry executives: "We're going to be cutting regulations at a level that nobody's seen before."

Professor Rasko, who is head of cell and molecular therapies at Royal Prince Alfred Hospital and affiliated with the University of Sydney, said: "The most extreme proponents of deregulation say the market should be the sole arbiter of utility: if a medicine sells well, then it must be safe and effective."