Two city lawmakers are demanding Mayor Bill de Blasio oust Health Commissioner Oxiris Barbot “before it’s too late,” saying her guidance on coronavirus has been disastrous.

Barbot “failed to take decisive actions to not only contain the virus early and flatten the curve, but her inaction has actually led to New York City becoming the epicenter of this pandemic,” City Councilmen Robert Holden and Eric Ulrich told de Blasio in a blistering letter obtained by The Post.

“Despite numerous warning signs from around the globe, Commissioner Barbot failed to keep New York City ahead of the curve. Significant research on pandemics and the spread of viruses should have been conducted early, and our city should have led the nation by taking drastic measures before any other city,” it says.

As the global outbreak heated up in January, Barbot repeatedly assured New Yorkers their risk was “low,” and to resume normal activities with only basic precautions such as washing hands.

On Feb. 2, with the city’s first suspected coronavirus case under investigation and China’s death toll skyrocketing, Barbot touted upcoming Chinese New Year events where crowds gather shoulder-to-shoulder in city streets.

“As we gear up to celebrate the #LunarNewYear in NYC, I want to assure New Yorkers that there is no reason for anyone to change their holiday plans, avoid the subway, or certain parts of the city because of #coronavirus,” she tweeted.

Five days later, she declared the city had little to worry about. “We’re telling New Yorkers, go about your lives, take the subway, go out, enjoy life,” she said.

Barbot gave the city a false sense of security instead of tackling the harsh reality with aggressive measures, Holden told The Post.

“We should have taken more drastic steps early. Now we’re paying the price in lives,” he said.

Barbot. a pediatrician, formerly served as Baltimore’s health chief before joining the de Blasio administration in 2014. He promoted her to commissioner in late 2018.

Ulrich blasted Barbot as “a zero.”

“She’s a self-proclaimed medical expert who got it terribly wrong,” he said. “We’re now facing the most devastating period in the outbreak. We need someone at the helm who is much more capable and competent to help us get through this. The mayor needs to find a new health commissioner — and he needs to do it fast, before it’s too late.”

On March 4, with COVID-19 cases emerging in Westchester County, Barbot dismissed the threat of infection by casual contact, saying, “There’s no indication that being in a car, being in the subways with someone who’s potentially sick is a risk factor,” the letter notes.

At a City Hall press conference on March 5, with “only four confirmed cases” in NYC, Barbot said the city was urging people who arrived from certain countries with rising cases to self-isolate, but everybody else without symptoms should not have to quarantine.

“No need for it,” she said.

It’s now widely accepted that COVID-19 can spread by people without symptoms, by casual contact, from touching virus-contaminated surfaces and through the air.

The councilmen blame Barbot for “irresponsible and reckless” inaction that helped spread the virus.

“She did not do enough to convince you to close public schools until March 16, and she failed to advise you to close playgrounds until Governor Andrew Cuomo made that decision for you,” it says.

The letter to the mayor said he should issue a directive that New Yorkers wear masks in public as other countries have done.

The next day, the mayor, with Barbot at his side, urged all people to wear homemade masks in public to control the spread of COVID-19.

“At this time, based on the history of misinformation, indecisiveness, and lack of proper planning, we have no confidence that Commissioner Barbot can effectively lead . . . the city’s response to this deadly pandemic,” the letter concludes.

Freddi Goldstein, a de Blasio spokeswoman, hit back:

“This is despicable and reeks of opportunism. Dr. Barbot has been expertly leading us through this crisis since Day 1 and there is absolutely no one more qualified to do so,” she said.

Councilman Mark Levine, (D-Manhattan), the health committee chairman, defended Barbot’s leadership as “outstanding.”

“She has given sober, science-based information to the public at every stage of this pandemic, including when some were still calling it a hoax. She sounded the alarm and fought hard for difficult shut-down measures when our city needed it,” Levine said in a statement.

Patrick Gallahue, a spokesman for Barbot said Saturday she has no plans to step down. “The Commissioner is solely focused on protecting the health of New Yorkers at this critical time and has every intention of remaining committed to that mission.”

Misdiagnosis

Two NYC lawmakers say city Health Commissioner Oxiris Barbot has repeatedly given bad advice on coronavirus. Some of her recent statements include: