Queensland Housing Minister Bruce Flegg has resigned days after a former staffer raised questions about the accuracy of his lobbyist register.

Dr Flegg was accused of not properly documenting interactions with this son, who works for lobbying firm Rowland.

The sacked staffer also alleged Dr Flegg's diary was altered to show he was working in his electorate when he was practising medicine.

Dr Flegg told Parliament the problems with the register were due to "sloppy administration" but no-one was to blame.

"It doesn't have to be something you have done yourself or even something about yourself," he said.

"If you hold the office of a minister, you have a responsibility over those matters - not one of these matters involved any personal gain for any person."

He became emotional as he told Parliament he wanted to prevent any further damage to the State Government.

"Madam Speaker, you might guess from my demeanour today that I am tendering my resignation to the Premier," he said.

"I want everyone in this place to understand fully I am taking that action.

"The Premier has not asked me or approached me in any way about that."

Sorry, this video has expired Watch Bruce Flegg's resignation speech as Minister in the Queensland Parliament.

Regret

Premier Campbell Newman says he accepted Dr Flegg's resignation with regret.

"I think Dr Bruce Flegg has this afternoon demonstrated incredible dignity and a great sense of honour in the way he has taken personal responsibility for administrative failings in his own office," he said.

"He has shown all of us what the ministerial tradition under the Westminster system is all about.

"I'm proud of him for coming in here and having the courage and the dignity to deliver that address that he just did."

Queensland Opposition Leader Annastacia Palaszczuk says Mr Newman should have intervened in the matter before this week.

"The Premier could have stepped in much earlier, at any time, and got to the bottom of it," she said.

"As we heard from the former senior media adviser, the former senior media adviser had approached Lee Anderson, the head of the government media unit.

"It is unbelievable to think that the head of the government media unit would not be in regular contact with the Premier updating him not these issues."

Dr Flegg is the second minister to go from the Newman Cabinet.

David Gibson quit as police minister in April - no more than two weeks after being sworn in - after revealing he allegedly drove a car while his licence was suspended.