Preheat oven to 350 F.Toss one slice of soft white bread in your food processor and grind it into crumbs. (Or use regular breadcrumbs or panko.)In a large bowl, use your hands to mix together one pound of lean ground beef, fresh bread crumbs, 1/2 cup of your favorite smoky barbecue sauce, 2 tablespoons Worcestershire sauce, 1 tablespoon spicy brown mustard (or dijon), 1 tablespoon honey, 1 teaspoon salt, and 1 teaspoon ground black pepper.Shape the mixture into a long, thick log and place in an oiled baking dish. Be careful not to pack the meat too tightly or you’ll end up with a very dense, tough loaf.In a small bowl, whisk together 1/4 cup barbecue sauce, 1 tablespoon honey, and 2 teaspoons Worcestershire sauce. Spread half of it evenly all over the meatloaf. Reserve the other half for serving.Bake for 45 minutes.Remove the meat from the oven and let it stand for 5 minutes.Slice and drizzle with the reserved barbecue sauce.