Jarryd Hayne has been ruled out of next week's deciding State of Origin game at ANZ Stadium with a hamstring injury.

The Parramatta fullback will be replaced on the wing by Newcastle's James McManus. Hayne's omission is a blow to NSW chances of ending Queensland's seven-year winning streak with Blues still having two key players under injury clouds for next Wednesday's match, with captain Paul Gallen (foot) and back-rower Greg Bird (ankle) also in doubt.

Jarryd Hayne injured his hamstring during the Eels' round 13 clash against the Roosters. Credit:Getty Images

Hayne was not optimistic about his chances of playing when he spoke on Monday morning saying the recent wet weather in Sydney had done him little favours in his recovery.

"It's not looking too good but I'm going to do everything I can to try and be right," Hayne said.