Citation: Lembo T, on behalf of the Partners for Rabies Prevention (2012) The Blueprint for Rabies Prevention and Control: A Novel Operational Toolkit for Rabies Elimination. PLoS Negl Trop Dis 6(2): e1388. https://doi.org/10.1371/journal.pntd.0001388 Editor: Jakob Zinsstag, Swiss Tropical Institute, Switzerland Published: February 28, 2012 Copyright: © 2012 Lembo, Partners for Rabies Prevention. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: The development of the website described in this manuscript was supported by the Global Alliance for Rabies Control, Food and Agriculture Organization, and European Commission (Directorate-General for Health and Consumers). The funders provided technical expertise in the creation of the website and were involved in the preparation of the manuscript describing this initiative. Competing interests: The authors have declared that no competing interests exist.

Introduction Rabies is a prime example of a neglected tropical disease that mostly affects communities suffering from inequitable health care [1]. The false perception that rabies impacts on society are low is due to case under-reporting and limited awareness of the disease burden [2], [3]. Effective tools for elimination of terrestrial rabies are available [4]. While the sustained deployment of these tools has led to some remarkably successful interventions [5], [6], canine rabies continues to claim lives in rabies-endemic countries and areas of re-emergence, where >95% of human deaths occur as a result of bites by rabid domestic dogs [7], [8]. Control programs targeting dogs can effectively reduce the risk of rabies to humans [3], [9]. However, the design and implementation of such programs still pose considerable challenges to local governments, and a lack of easy-to-use guidelines has been identified as an important reason for this. Global rabies experts from the Partners for Rabies Prevention have therefore gathered to translate evidence-based knowledge on rabies control into user-friendly guidelines. Existing information obtained from different sources, including previously published guidelines by international health and animal welfare organizations and scientific findings, has been packaged into a novel online document, the Blueprint for Rabies Prevention and Control (http://www.rabiesblueprint.com), which we describe herewith.

The Website The ultimate goal of the Rabies Blueprint is to provide relevant authorities and personnel in rabies-affected areas with a standard operating procedure (“Blueprint”) to develop their own programs for preventing human rabies through canine rabies elimination and control of wildlife rabies. This document is not meant to replace national legislation or existing guidelines. Rather, it brings all relevant information into one accessible document to make the design of rabies management programs easier globally, both in areas where rabies is endemic or has been re-introduced. This toolkit has been developed based on the following principles: (1) create a multi-disciplinary working group combining all disciplines/institutions required for formulating comprehensive guidelines for a “One Health” approach to controlling rabies [10]; (2) build upon research-based material to summarize critical information and provide key take-home messages, with links to more detailed information; (3) provide country-specific examples that address common misperceptions and illustrate successful rabies control programs in a range of settings to encourage appropriate investment and efforts elsewhere; (4) follow a question-and-answer approach, reflecting the most frequently asked questions on rabies prevention and control; (5) use language that is understandable by a wide range of users, including professionals and field personnel; (6) use an openly accessible Internet-based format; and (7) develop a low-resolution website to allow users with low Internet speeds or a mobile phone connection to navigate the system. The current version of the Rabies Blueprint focuses on dogs as reservoirs, in recognition of the amplified risk to human health from canine rabies. The Rabies Blueprint provides step-by-step guidelines to prevent human rabies by eliminating canine rabies. It addresses key issues that users should consider to achieve this goal, as summarized in the diagram in Figure 1. The document comprises four sections and an introduction, which provides general information about rabies and rabies control strategies. The sections can be accessed from the home page or a simple diagram (http://www.rabiesblueprint.com/spip.php?article119). PPT PowerPoint slide

PowerPoint slide PNG larger image

larger image TIFF original image Download: Figure 1. Screenshot of the Rabies Blueprint home page ( http://www.rabiesblueprint.com). The sections of the document can be accessed from the left navigation bar, the site map or the diagram to the right, which provides a summary of all components of a successful canine rabies control/elimination program. https://doi.org/10.1371/journal.pntd.0001388.g001 The “Roles and Responsibilities” section identifies relevant agencies for all activities related to rabies control programs and defines roles and responsibilities of all sectors involved, emphasizing the importance of building political commitment and establishing cooperation and dialogue amongst all parties. The minimum amount of infrastructure required, legislative frameworks, resource requirements, and funding opportunities are provided in a subsequent section. Given the importance of enhancing public awareness on rabies prevention and control, the website devotes an entire section (“Communications plan”) to health communication strategies and provides the first rabies communications plan for incorporation into a canine rabies elimination program. This section includes information on how effective communication planning can help raise awareness on rabies; the eight interrelated steps of communication planning; and guidelines for developing country-specific rabies communication plans adaptable to the cultural, political, and behavioral needs of any location. Finally, the “Operational activities” section contains details of the actual program implementation: epidemiological information required; supplies needed; personnel and training requirements; surveillance mechanisms and diagnostics; operational activities related to the “attack/elimination” component (mass vaccination, dog population management, and human prophylaxis); indicators of success; and requirements to ensure maintenance of a rabies-free status once the disease has been eliminated, including sustainability mechanisms. Table 1, based on selected popular pages, provides details of the type of information that users can obtain from a number of sections as well as from internal and external links included in each section. PPT PowerPoint slide

PowerPoint slide PNG larger image

larger image TIFF original image Download: Table 1. Examples of the most popular pages of the Rabies Blueprint website based on number of visits recorded since the launch of the website. https://doi.org/10.1371/journal.pntd.0001388.t001

Impact Just over one year after the launch of the website in late June 2010, evaluation of its performance indicates that the initiative has had a global impact. Visitors have come from 157 countries/territories and 1,719 cities within the Americas, Europe, Asia, Africa, and Oceania. The number of visits has exceeded 46,000, with consistently >2,000 visitors per month and an average of 80 users daily. Most users (75%) have accessed the English interface. To date, there are several examples of the adoption of this toolkit in a range of countries, such as Uganda, Benin, Afghanistan, Peru, Bolivia, Haiti, and Bali, and evaluation of its impact on rabies control efforts in individual countries is currently being undertaken.

Conclusions and Future Directions The multi-disciplinary approach required for the design of effective rabies elimination strategies has linked together veterinarians, public health workers, ecologists, and vaccine producers, which is the first of two important achievements of the Rabies Blueprint initiative. The truly innovative feature of this project is undoubtedly the delivery of a powerful and practical tool directly into the hands of all those with a desire to achieve rabies elimination (Box 1), which makes the Rabies Blueprint a major breakthrough in the global fight against rabies. However, work is still necessary to optimize the website. The expansion from a bilingual (English/French) to a multilingual interface is an essential first step to further increase its global outreach. Translations into Spanish, Portuguese, Russian, Arabic, and Persian have been undertaken, but additional languages will need consideration to reach countries where rabies is an emerging problem (e.g., China and Indonesia). Similarly, although an interactive CD containing a copy of the website has been developed for areas with no or limited Internet access, this is currently only available in English/French. Finally, enduring efforts will be required to ensure incorporation of new/revised recommendations, as well as new tools and ideas, and provide access to additional rabies resources as they become available. An essential next step will be the inclusion of components focusing on wildlife species implicated in rabies maintenance worldwide. Box 1. Strengths and Weaknesses Strengths Freely accessible through the Internet (http://www.rabiesblueprint.com)

All of the most recent information, including case studies, in one single document

Easy to navigate

Clear step-by-step recommendations

Easy to update

Language/style understandable by a wide range of users, from professionals to field teams

Applicable from individual exposure to large-scale interventions

Impact and performance can be monitored

Bilingual interface

Upgradable to cover all other reservoir species Weaknesses Compared to paper-based guidelines, it requires an Internet connection (website) or access to a computer (CD)

Potential language barriers

Potential conflicts with existing national guidelines

It does not overcome financial and political barriers to canine rabies elimination

Acknowledgments Contributors to the Rabies Blueprint initiative include: Animal Health and Veterinary Laboratories Agency (Anthony Fooks); Canadian Food Inspection Agency (Alexander Wandeler); Centers for Disease Control and Prevention (Charles Rupprecht, Abbigail Tumpey, Andrés Velasco-Villa, Sergio Recuenco); DodetBioscience (Betty Dodet); European Commission (Moritz Klemm); Food and Agriculture Organization (Katinka de Balogh, Olivier Adier, Toni Ettel); French Food Safety Agency (Florence Cliquet); Friedrich-Loeffler-Institute (Thomas Müller, Conrad Freuling); Global Alliance for Rabies Control (Deborah Briggs, Peter Costa, Mary Elizabeth Miranda, Robert Dedmon, Louise Taylor, Kim Doyle); IDT Biologika GmbH (Adrian Vos); Institut Pasteur (Hervé Bourhy, Noël Tordo); KwaZulu - Natal Rabies Project (Kevin Le Roux); Merial (Carolin Schumacher, Joanne Maki); Novartis (Ferdinando Borgese, Dieter Gniel); Pan American Health Organization (Fernando Leanes, Marco Antonio Natal Vigilato); Sanofi Pasteur (Michaël Attlan); Thai Red Cross Society (Boonlert Lumlertdacha); Universitá di Torino (Natalia Cediel); University of Glasgow (Tiziana Lembo, Sarah Cleaveland, Katie Hampson); University of Pretoria (Louis Nel); World Health Organization (François-Xavier Meslin); World Organization for Animal Health (Lea Knopf); World Society for the Protection of Animals (Elly Hiby).