Do not allow a guilt tripper to get the reaction she's trying to get. Defuse the guilt trip by resisting the temptation to feel guilty. Address the concern and hurt feeling behind the guilt trip if you feel it's fair and necessary to do so, but be firm so that the tripper knows she doesn't control you. Ask her to rephrase her comment. Say things like, “I don't believe that's a fair assessment of the situation. Can you tell me what you're feeling right now?” Listen and address her core concerns in a manner that is consistent to what you believe and your principles, not necessarily according to her wishes.