Marie Severin, a multifaceted comic book artist whose confident hand drew most of the greatest heroes in the Marvel Comics pantheon at a time when women were rare in that field, died on Wednesday at a care facility in Amityville, N.Y. She was 89.

She had had a stroke, said Scott Edelman, a friend and former Marvel colleague who confirmed the death.

Ms. Severin was a consummate comic book artist, engaged in most parts of illustrating a comic book, which involves penciling outlines of the characters and scenes, finalizing the images in ink and then coloring them in.

She started in the industry in 1949 as a colorist for EC Comics, working with her brother, John Severin, an artist known for his realistic war and western comics. She was one of a handful of female artists who gained prominence during comics’ so-called Silver Age, from the mid-1950s until the early ’70s.