Travel is, by definition, dislocating, a condition that the trend toward experiential travel and the connectivity provided by the internet aim to ease.

“The first question is whether you should feel at home while you’re away,” said Tom Hall, editorial director for Lonely Planet guidebooks. “That feeling of difference is one of the joys of travel, as with it comes the invisibility to explore and to learn simply by being somewhere.”

Yet even seasoned travelers can experience discomfort. Strategies for dealing with the physical side effects of travel start with the basics, including getting adequate sleep and exercise.

“Although you may be going for pleasure, you’re out of your routine, and that can speed up your body and mind to act differently,” said Patricia Thornton, a psychologist in Manhattan and a member of the Anxiety and Depression Association of America.