The league had their entire opening weekend in the same location as Torino hosted half of the games on Saturday and the other half on Sunday. The league expanded back to twelve teams this season and Sesto San Giovanni made their return, losing to Dearica Hamby and Ragusa 78-51. Next, Anete Steinberga and Venezia beat Broni 82-60 as Marie Gulich played her first game back in Europe. The day ended with extra basketball as Napoli edged Adrienne Webb and San Martino di Lupari 72-70 in a game that featured the healthy return of Isabelle Harrison and an overseas debut for Gabby Williams. Empoli had a credible debut in the top division as the newcomers also gave Aliyah Huland El and Erin Mathias their professional debuts, but Lucca won 75-67 behind Krystal Vaughn. Schio got an unexpectedly tough challenge from Battipaglia as Kristen Simon played her first professional game, but won 69-63. The home fans got promising performances from their new professionals as Taya Reimer and Kahlia Lawrence helped them beat Vigarano 77-69. Michaela Rakova started her career back in Europe for the visitors after finishing her college career.

October 6, 2018

Sesto San Giovanni vs. Ragusa 51-78 SES Loyd 11 Brunner 10 Williams 7/6a RAG Hamby 21/15r Harmon 18/7r Kuster 13/10r Cinili 12

Venezia vs. Broni 82-60 VEN Steinberga 23/6r De Pretto 12 Gorini 11/7a Bestagno 11 Anderson 7 Gulich 4 BRO Milic 17/6r Castello 13 Spreafico 10 Wojta 2

Napoli vs. San Martino di Lupari 72-70(OT) NAP C. Williams 18/8r/6s G. Williams 17/11r Harrison 14/8r Macchi 13/6a Ress 4 SAM Webb 23 Marshall 13/8r/7a Dotto 10

October 7, 2018

Lucca vs. Empoli 75-67 LUC Vaughn 25/12r Treffers 18/15r Gatti 16/8a Graves 10/9r Ravelli 3 EMP Huland El 15 Mathias 14/9r Pochobradska 13

Schio vs. Battipaglia 69-63 SCH Lisec 13 Dotto 12 Andre’ 10/6r Masciadri 8 Gemelos 7/7r Gruda 2 BAT Brown 15 Trimboli 12/7r Simon 11/6r Mataloni 11 Handy 7

Torino vs. Vigarano 77-69 TOR Reimer 23 Milazzo 18/8a Lawrence 9 VIG Fitzgerald 19/9r Bolden 16/6r Rakova 10/14r