Drivers in Victoria will face the state's biggest-ever road blitz over summer, with police "locking down" suburbs and blitzing major roads across Melbourne.

Along with additional mobile speed cameras, radar guns, booze and drug buses, police will use every available local resource in a four-month campaign aimed at reducing road fatalities during the holiday season, Assistant Commission Robert Hill said yesterday.

Mr Hill revealed that many suburbs would go into "lock downs", which would see police officers and drug and booze buses stationed at most roads leading to freeways and major arterials.

"We'll deploy resources, our booze buses, our drug buses, our state high patrol to a particular suburb, and we'll lock that suburb down in what we call a 'ring of steel,'" the Assistant Commissioner told radio station 3AW on Tuesday.