Ultimate Spider-Man is a video game based on the comic book of the same name by Brian Michael Bendis and Mark Bagley. The game was released for most sixth generation consoles, including PlayStation 2, Xbox, GameCube, Nintendo DS, Game Boy Advance, and Microsoft Windows, as well as a mobile phone version. Treyarch, who made the console games based on the Spider-Man movies, developed the console game, while Vicarious Visions developed the Nintendo DS and Game Boy Advance versions, and Beenox ported the Microsoft Windows version from the consoles.

Stylistically, it differs from its predecessor, Spider-Man 2, in that it employs what has been dubbed, "Comic Inking Animation technology," a form of cel shading intended to simulate the appearance of a comic-book.

While originally thought to be canonical to the Ultimate Spider-Man comics, it is unclear what parts of the game take place in the continuity of the comic. The story arc "War of the Symbiotes" loosely adapts the events of the game into Ultimate Universe continuity, while shortening and changing many of the story elements.