A: “Yes, he’s based on William Halstead + a few other doctors from the era. Halstead was a cocaine and morphine addict.” - @MichaelBegler — The Knick (@AtTheKnick) October 18, 2014

Q: “Is the woman that plays "Typhoid Mary” the same as the mother of the girl Edwards stitches up early in the season?“ #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A: "No, they’re two totally different actresses, though they do bear a resemblance to each other.” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q: “Why would Elkins want Thackery, an old, cocaine-addled grumpy dude? She’s a young pretty thing.” - @bhern #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“She’s a nurse who believes she can save people. Thackery represents adventure but also her ultimate patient.” - @MichaelBegler #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q: “What was the biggest inspiration in making the show + what kind of medical discoveries are we in for in the next season?”#TheKnick — The Knick (@AtTheKnick) October 18, 2014

A: “As for next year, can’t reveal much, but I promise fewer babies die, + there will be more fascinating procedures + medicine.” @jackamiel — The Knick (@AtTheKnick) October 18, 2014

Q:“Is the opium a substitute of cocaine for Thackery or a relaxation or something?” - @samwoolfsconsi #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Opium brings him down. It’s the drug he uses to balance out all his cocaine use at the end of the day.” - @MichaelBegler — The Knick (@AtTheKnick) October 18, 2014

Q:“@AtTheKnick why didn’t you use Wu’s ass kicking abilities earlier?!??!” #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“We did after Thack saves Wu from choking, where Wu’s in The Knick during the riot as a patient, and is badass. We cut it..” - @jackamiel — The Knick (@AtTheKnick) October 18, 2014

A:“It’s more fun to find this stuff out naturally, + Wu, who is based on some Tong leaders of the era, is full of surprises.” - @jackamiel — The Knick (@AtTheKnick) October 18, 2014

Q:“Was Wu based on a real person like Thackery?” - @GlenCarballo #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Yes, like Thackery, Ping Wu was based on a few Chinese Gangsters. One did wear chain mail + carried a hatchet.” - @MichaelBegler — The Knick (@AtTheKnick) October 18, 2014

Q:“Did you originally plan Thackery’s arc for one season, or did you always have more in mind?” -@roryplante #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“We always had more in mind. As you plan S1, there are so many things you want to do, that you start pushing them to S2.” - @jackamiel — The Knick (@AtTheKnick) October 18, 2014

Q:“Why did the rehab doctor give heroin to him when he’s ALREADY HOPPED UP ON COCAINE?” - @colonelbrian #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Heroin was a brand new drug + was considered a miracle. Doctors truly believed in it as a cure for addiction.” - @MichaelBegler — The Knick (@AtTheKnick) October 18, 2014

Q:“What was the inspiration or thought process behind using such a unique score as opposed to sticking to period music?” #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“That was totally Soderbergh’s genius. He wanted it modern to keep you feeling the show was immediate + not old-timey.” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q:“What happened to "The Golden Lotus” Lucy owes Wu? You named an episode after it!! Well?“ - @1UFCAddict #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:"Lucy performed the Golden Lotus. It’s how she got Thack the opium + yet still had her bike + the $100.” - @MichaelBegler #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Strychnine was used as a stimulant. An addict who is missing his fix will try anything to stop tweaking, thus strychnine.” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q:“Will we see more of Cornelia’s brother next season?” -@ariannabanana #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Yes. Henry is back in New York for good.” - @MichaelBegler #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q:“Is Cornelia in love with Edwards?” #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Wouldn’t you be? He’s a gem. He’s pragmatic though + knows he needs to bury the feelings.” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Cornelia’s always gotten her way, + can’t let go.” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q:“Will Chickering decide to leave the practice now and work for Zingberg?”- @TheRealHoax #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Bertie has a lot to think about while Thack is away.” - @MichaelBegler #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q:“Is Barrow the type that thinks every prostitute is in love with him?” -@Alex_Chap #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Not every prostitute, just Junia. She’s touched his heart… and uh, other things.”- @MichaelBegler #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q:“Is Cap’t Robertson in debt & hiding it? His son talking about having to save his business in San Fran was shocking! ” #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Robber barons were boom + bust. They took huge risks to expand, competition was cutthroat.” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“He’s struggling more than he’d like to admit. He might be losing his edge, + a new generation’s contribution might help.” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q: “What will become of Cornelia? Is she gone from the show? ” - @dfieha #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q:“ I watched EVERY episode multiple times! Where/How did Cleary get that huge bag of money?” #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“He got the bag of money from Cornelia. She had a driver bring him hush money.” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q:“The Vanderbilts just about owned NY during this era. Will we be hearing about them in #TheKnick?” - @JoAnn0924 — The Knick (@AtTheKnick) October 18, 2014

A:“We may hear a little more about the Vanderbilts in S2, but the Robertsons are sort of a stand-in for the Vanderbilts.” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q:“No teeth?! Please @JackAmiel tell me y'all made that treatment up and it wasn’t based on historical fact.”- @Darian_Robbins — The Knick (@AtTheKnick) October 18, 2014

A:“That treatment was courtesy of the real Dr. Cotton who worked at the NJ State Mental Hospital, + did exactly what we showed.” @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q:“Are Bertie’s eyes finally opened about Thack, The Knick, and Eve?” - @TNORMOUS #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Bertie’s eyes are open, as seen in his response to finding out about them. But love is hard to shake, #Forgiveness?” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

A:“Edwards dead? Not sure even he knows the answer to that right now. You’ll just have to wait and see, sorry.” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q:“Was most of the medical research was done before the show was written?” #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Did 5 months of research before writing, but during the writing we continued to dig even more specifically.” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q:“Are we going to see more of Inspector Speight in season two?” - @jaycup92 #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Can’t say whom we are going to see or not. I can tell you that Speight figures importantly into Season 2.” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q:“Will we delve deeper into Ping Wu? We could use a little more Wu.” - @Robbulous #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“We are big Wu fans. Love Perry’s portrayal. If Barrow now owes him 10Gs, then chances are we’ll see more of Wu.” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014

Q:“Is there a chance for peace between Gallinger + Edwards?” #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“It won’t be easy to make peace. Will Gallinger finally accept Edwards, or harden more? Will Algernon forgive …?” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q:“Is Thackery involved in medicine for the glory of the discovery, or to really help people?” - @FictionPinnacle #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Thack’s in it for glory + kindness. He’s driven by ambition + survives the death, b/c he believes he’ll eventually help.” - @JackAmiel — The Knick (@AtTheKnick) October 18, 2014

Q: “Would Dr. Zimburgh have been impressed by the vacuum Edwards adapted for the #TheKnick?” - @linwoodpk — The Knick (@AtTheKnick) October 18, 2014

A:“Absolutely, Zinberg would have loved the vacuum. Would he accept Edwards? They’re both outsiders.” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014

A:“Does that make for kinship or rivalry though?” - @JackAmiel #TheKnick — The Knick (@AtTheKnick) October 18, 2014