The 3D deposition process can even be used to manufacture nested spirals (microscope image; original width approx. 50 micrometres). (Photo: Hirt L et al., Advanced Materials 2016, reproduced with permission of Wiley-VCH)

Using a computer to control the movement of the micropipette, the researchers can print three-dimensional objects pixel by pixel and layer by layer. The spatial resolution of this process depends on the size of the pipette’s aperture, which in turn determines the size of the copper deposits. At present, the scientists can produce individual 3D pixels with diameters ranging from 800 nanometres to more than five micrometres, and can combine these to form larger 3D objects. In an initial feasibility study, various spectacular microscopic objects were created. They consist of pure, non-porous copper and are mechanically stable, as studies by scientists from the group led by Ralph Spolenak, Professor of Nanometallurgy at ETH Zurich, showed. A particularly impressive object consists of three nested microspirals, which the ETH researchers manufactured in a single step and without using a template.

“This method can be used to print not only copper but also other metals,” says Tomaso Zambelli, associate lecturer and group leader at the Laboratory of Biosensors and Bioelectronics at ETH Zurich. And FluidFM may even be suitable for 3D printing with polymers and composite materials, he says.

An advantage of the new method over other 3D microprinting processes is that the forces acting on the tip of the pipette can be measured via the deflection of the leaf spring on which the micropipette is mounted. “We can use this signal as feedback. Unlike other 3D printing systems, ours can detect which areas of the object have already been printed,” says Hirt. This will make it easier to automate the printing process.

Successful collaboration with a spin-off

The scientists have submitted a patent application for the method. The ETH spin-off Cytosurge has now licensed the method from ETH Zurich. Pascal Behr played a key role in developing FluidFM at ETH several years ago. Today, he is CEO of Cytosurge. “We see big market potential in the printing process and an opportunity to further diversify our company,” he says. “We are convinced of the idea of using FluidFM in 3D microprinting. Now, the task is to optimise this application in collaboration with interested researchers at universities and in industry – for example, in the watchmaking, medical technology and automotive sectors.” Behr sees an initial application in the field of rapid prototyping, where microscopic components can be manufactured quickly and easily using 3D printing.

The long-established collaboration between ETH Zurich and Cytosurge will also continue. “It is a case of mutual give and take, from which both sides profit,” says Zambelli. Cytosurge provides ETH with its latest equipment, which the ETH scientists are able to use for their research. They in turn help to test the devices and offer suggestions for improvements and further development.