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"We are going to win Florida. Period. Take it to the Bank," tweeted Rubio aide Todd Harris, who said the new poll numbers are "way wrong."

Media needs to chill. The FL Q poll #'s are way wrong. We are going to win Florida. Period. Take it to the bank. — Todd Harris (@dtoddharris) February 25, 2016

"Take it to the bank," is also the phrase former candidate Jeb Bush used to express his optimism about winning the South Carolina Republican primary. The former Florida governor instead finished in fourth place with 8 percent of the vote in that state and dropped out of the race shortly after the results were posted in the Palmetto State.

Rubio's campaign manager, Alex Conant, on Thursday also made clear that he isn't worried about the new poll, tweeting that the media is overhyping Trump's chances.

How reporters think: "There's 20 days, 15 elections, 3 debates, millions spent before Florida. BUT OMG A POLL SAYS MARCO IS LOSING TO TRUMP" — Alex Conant (@AlexConant) February 25, 2016

Thursday's Quinnipiac poll shows that Trump is leading Rubio in Florida, 44 to 28 percent, ahead of the state's primary on March 15.