HOUSTON — Asked what went wrong for his Tampa Bay Rays, manager Kevin Cash invented a word.

“We got Verlandered,” Cash said.

Justin Verlander looked every bit the October ace, Jose Altuve polished his postseason resume and the Houston Astros kept rolling, beating the Rays 6-2 Friday to open their AL Division Series.

The Astros, who won a franchise-record 107 games for the best record in the majors, began their quest for a second World Series title in three years against a Rays team that downed Oakland 5-1 in the wild-card game this week.

Verlander kept up his dominant run this year when he posted an MLB-most 21 wins and fanned 300, allowing just a soft single in seven shutout innings. He struck out eight and improved to 8-0 in 12 career ALDS appearances — he’s 14-7 overall in postseason play.

He cracked up when told Cash used his performance to turn his name into a verb.

“It’s a pretty great compliment,” Verlander said. “I don’t know what else to say, other than that.”

Tampa Bay got its only hit off Verlander when Brandon Lowe singled to start the fifth. Verlander ended his day by striking out the side in the seventh, pounding his fist into his glove as he walked off the mound after fanning Lowe.

Manager AJ Hinch was asked about Verlander’s knack for getting stronger late in games.

“He’s got an incredible instinct for the moment,” he said. “He leaves some gas in his gas tank at the end of his outings … like a good sprinter, like at the finish line, he’s going to win. He’s going to win the race at the end of his outings.”

Rays starter Tyler Glasnow had given up just three singles when he walked Josh Reddick on four pitches to begin the fifth. He struck out George Springer, but Altuve then tagged him for a two-run homer, lining a fastball into the left field seats.

“I just left that pitch up and it was a two-run home run,” Glasnow said. “Hindsight, I would go back and change some things, but can’t do anything about it now.”

The sellout crowd of 43,360, which included Astros Hall of Famers Nolan Ryan and Craig Biggio, erupted into deafening cheers and fans twirled bright orange towels as Altuve trotted around the bases, a huge grin plastered on his face.

Altuve has homered in Game 1 of the ALDS for three straight years — including three against Boston in the 2017 opener — and the small-but-powerful second baseman now has nine home runs in 33 career postseason games.

“Just breaking through with the big swing for Jose doesn’t surprise me,” Hinch said. “It’s like clockwork, every ALDS it seems like he busts out with a really good game.”

Game 2 is Saturday when Gerrit Cole, who has won 16 straight decisions and led the majors in strikeouts, starts against Tampa Bay’s Blake Snell.

Altuve’s homer touched off a four-run inning. Brendan McKay took over for Glasnow and allowed a single to Michael Brantley before Alex Bregman knocked one off the wall in left for a double.

Chaz Roe relieved with two outs and Yuli Gurriel hit a high popup to shallow right field that Lowe chased from second base as right fielder Austin Meadows also dashed in. Lowe looked to have it, so Meadows pulled up — but the ball glanced off Lowe’s glove for an error that allowed two runs to score to push the lead to 4-0.

“I have to catch it plain and simple,” Lowe said. “I called it and I dropped it. Next time I just have to keep going for it and make a play on it.”

The Astros added two more runs in the seventh after Bregman walked and stole second base. AL Rookie of the Year candidate Yordan Alvarez and Gurriel followed with RBI doubles to make it 6-0.

Tampa Bay hit four home runs in its wild-card win Wednesday at Oakland, but did nothing until Verlander left. Pinch-hitter Eric Sogard had an RBI single of Ryan Pressly with two outs in the eighth and scored on a double by Meadows to cut the lead to 6-2.

Glasnow, who came to the Rays in last year’s trade for Chris Archer that also netted Meadows, looked strong early and Houston’s powerful offense had trouble stringing anything together off him until Altuve’s shot. The Astros loaded the bases with two outs in the third, but the big right-hander struck out Alvarez to end the threat.

The 26-year-old Glasnow, who was making his playoff debut had missed almost four months with a strained right forearm before his return on Sept. 8, seemed to run out of gas in the fifth. He allowed four hits and two runs with five strikeouts in 4 1/3 innings.

Yandy Díaz, who starred with two homers and three hits in the wild-card game, was 0 for 4 with a strikeout.