The present invention is related to the field of bio-artificial liver technology . Particularly the invention provides an integrated hybrid bio-artificial liver support system that provides the features of artificial liver assist devices with that of bio- artificial liver support system. This can provide temporary support to the failing liver. This system will have a plasma separation unit, detoxifier unit and bioreactor system integrated in it. This system also facilitates the circulation of nutrients like glucose, saline and other forms of nutrients to the cell seeded in the cryogel matrix.