On Oct. 1, the deadliest mass shooting in modern U.S. history occurred in Las Vegas when a gunman opened fire on an outdoor country music festival from the 32nd floor of the Mandalay Bay Hotel. The following night, late night hosts addressed the senseless violence on their programs.

Kimmel, a Vegas native, opened his show on Oct. 2 with a teary monologue. "Here we are again in the aftermath of another terrible, inexplicable, shocking and painful tragedy — this time in Las Vegas, which happens to be my hometown. Of course, we pray for the victims and for their families and friends, and we wonder why, even though there's probably no way to ever know why a human being would do something like this to other human beings who were at a concert having fun, listening to music." He went on to call out "our so-called leaders" and question why they continue to allow these deadly acts of violence to occur. "Maybe a better question — why do we continue to let them allow it to happen?" the host asked. The host noted that his stance wasn't about gun control but about "common sense," adding, "Common sense says no good will ever come from allowing a person to have weapons that can take down 527 Americans at a concert. Common sense says you don’t let those who suffer from mental illness buy guns."

Meyers shared a similar sentiment on his program, saying, "It always seems like the worst displays of humanity in this country are immediately followed by the best, and then, sadly, that is followed by no action at all. And then it repeats itself." He then made a pointed statement to Congress: "I would just like to say — are there no steps we can take as a nation to prevent gun violence? Or is this just how it is, and how it's going to continue to be?"

On the Daily Show, host Trevor Noah also made a political cry for gun control, saying, ""To the people of Las Vegas, I can't give you thoughts and prayers. I can only say that I'm sorry. I'm sorry we live in a world where people will put a gun before your lives."

On TBS, Conan O'Brien expressed his sadness over the "terrible and numbing" tragedy, telling his audience, "When I began in 1993, occasions like this were extremely rare. For me, or any TV comedy host, to come out and need to address a mass shooting spree was practically unheard of. Things have changed."

After expressing his sorrow for the victims and families, Stephen Colbert took jabs at President Trump during his opening remarks, urging Trump to be the president to make a difference. “Today, the president called this an ‘act of pure evil.’ And I think he’s right,” Colbert began. “So what, then are we willing to do to combat ‘pure evil?’ The answer can’t be nothing.” He further pressed the issue, saying, "You want to make America great again? Do something the last two Presidents haven’t been able to do. Pass any kind of common sense gun control legislation that the vast majority of Americans want. Think about what you need to do and pray for the courage to do it.”