BEIRUT, Lebanon — President Bashar al-Assad of Syria fired the governor responsible for the city of Hama on Saturday, a day after tens of thousands of protesters filled its streets in the largest demonstration since the uprising began in March.

The move seemed at least in part an effort to appease the protesters in Hama, where demonstrations have grown bigger and more persistent since the military and the security forces withdrew in June for reasons that remain unclear. On Friday, some residents put the crowd at more than 100,000 in scenes redolent of Tahrir Square in Cairo in February, as youths climbed on cars to deliver chants, songs and speeches and residents offered water and bananas to protesters on a hot summer day.

A conservative Sunni Muslim city on the main corridor that links Damascus with Homs and Aleppo, Hama carries symbolic weight. In the culmination of a struggle between the government and an armed Islamic opposition in 1982, government forces stormed the city, killing at least 10,000 people and flattening part of the old quarter. Some estimates put the number of dead higher, and nearly 30 years later, cries for vengeance over Hama still occasionally punctuate this uprising.

After particularly bloody protests in Hama on June 3, in which government forces killed as many as 73 people, the military and the security forces largely abandoned the streets. On Friday, not even traffic officers were out. The government also took steps to contain the crisis, firing the chief of security in the city and reaching an agreement with residents to allow peaceful protests as long as no property was damaged.