As Donald Trump proved in the 2016 election, pummeling your Democratic opponent is most effective when done early and often. Of course, it doesn’t hurt when that candidate is the frontrunner from the very beginning, or when she has a decades-long record in public office to draw on, as Hillary Clinton did. So it comes as little surprise that Republicans are pre-emptively targeting progressive Senator Elizabeth Warren, among other potential 2020 candidates, in order to dirty her reputation long before the actual presidential election season begins in earnest.

Warren, who made a name for herself as an anti-Wall Street firebrand in the Bernie Sanders mold, is expected to easily win re-election in Massachusetts in 2018. But G.O.P. operatives aren’t waiting for Warren to run in 2020 before using the upcoming election as an opportunity to launch a familiar set of attacks. Politico reports that a mysterious super PAC called Massachusetts First has begun a campaign to “bring to light her hypocrisy and out-of-touch policy positions,” running radio ads and raising $200,000 to continue its attack against the “hypocrite professor” from Harvard. A whopping $150,000 of Massachusetts First’s war chest was donated by Robert Mercer, the billionaire Trump supporter who is also a major stakeholder in Breitbart News and a longtime patron of Steve Bannon. Notably, it was the largest donation Mercer made this year, according to F.E.C. records.

Outside of Massachusetts First—a reference to Trump’s “America First” slogan—other groups are coalescing around an anti-Warren campaign. America First Action and America Rising, two pro-Trump super PACs, have begun collaborating in their anti-Warren opposition research and strategy, Politico reports. Trump’s re-election committee itself began operations within days of his inauguration, released an ad this month calling her a “career politician.”

Warren isn’t the only Democrat on the G.O.P.’s radar, of course. Trump’s allies have also begun compiling opposition strategies to take down Senators Bernie Sanders, Sherrod Brown, Kirsten Gillibrand, Amy Klobuchar, Chris Murphy, and Cory Booker, as well as Governor Andrew Cuomo, among others. All but Booker face re-election in 2018—an opportunity for each to build their war chest and raise their national profile, and for Republicans to try to tear them down. Trump’s allies are particularly eager to kneecap Brown, Politico reports, a finalist to be Clinton’s vice president whom they believe they can unseat before he has a chance to build momentum for a 2020 campaign. Of course, Republicans may have some help in that endeavor. Even if they had all the “dark money” they needed, Republican PACs could come in under-budget as the Democratic Party grapples with its own internecine identity crisis.