A 16-year-old boy is in an induced coma and four other teenagers are being treated in hospital after a car crash at Mount Tamborine in the Gold Coast hinterland.

Police said the 16-year-old was driving east along Beacon Rd about 5:45am when he lost control and the sedan rolled.

Two 14-year-old boys were trapped in the back seat of the car, and it took emergency services half an hour to cut them free.

One has been flown to the Queensland Children's Hospital with a serious arm injury and the other is in the Gold Coast University Hospital (GCUH).

The third boy seated in the back of the car suffered minor injuries and is in a stable condition in the GCUH, along with the 14-year-old front-seat passenger who has a minor shoulder injury.

Paramedics treat a teenager seriously injured in the crash. ( ABC News )

The driver suffered significant head and chest injuries and was flown to the Queensland Children's Hospital where he remains in an induced coma.

Queensland Ambulance acting senior operations supervisor Bill Houghton said it was a significant operation, requiring eight ambulance crews and two rescue helicopters.

"Obviously it is a bit traumatic with the ages of the occupants," he said.

"The take-home message is just be careful, just be mindful of other road users and yourself and use common sense."

Mr Houghton said he didn't know if the driver was licensed.

The Forensic Crash Unit is investigating the cause of the accident.