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BENZODIAZEPINE EQUIVALENCE TABLE

(Benzodiazepine Equivalency Table)

Revised April 2007

This Benzodiazepine Equivalence Table is based on the extensive research and clinical experience of Professor C Heather Ashton, DM, FRCP, Emeritus Professor of Clinical Psychopharmacology at the University of Newcastle upon Tyne, England. Sources: NRHA Drug Newsletter, April 1985 and Benzodiazepines: How they Work & How to Withdraw (The Ashton Manual), 2002. The approximate equivalent doses to 10mg diazepam (Valium) are given.

For a discussion of half-lives and equivalencies see also the Benzo FAQ document.

Benzodiazepines1 Half-life (hrs)2

[active metabolite] Approximately Equivalent

Oral dosages (mg)3 Market Aim4 Alprazolam

(Xanax, Xanor, Tafil) 6-12 0.5 a Bromazepam

(Lexotan, Lexomil) 10-20 5-6 a Chlordiazepoxide

(Librium) 5-30 [36-200] 25 a Clobazam

(Frisium)5 12-60 20 a,e Clonazepam

(Klonopin, Rivotril)5 18-50 0.5 a,e Clorazepate

(Tranxene) [36-200] 15 a Diazepam

(Valium) 20-100 [36-200] 10 a Estazolam

(ProSom, Nuctalon) 10-24 1-2 h Flunitrazepam

(Rohypnol) 18-26 [36-200] 1 h Flurazepam

(Dalmane) [40-250] 15-30 h Halazepam

(Paxipam) [30-100] 20 a Ketazolam

(Anxon) 30-100 [36-200] 15-30 a Loprazolam

(Dormonoct) 6-12 1-2 h Lorazepam

(Ativan, Temesta, Tavor) 10-20 1 a Lormetazepam

(Noctamid) 10-12 1-2 h Medazepam

(Nobrium) 36-200 10 a Nitrazepam

(Mogadon) 15-38 10 h Nordazepam

(Nordaz, Calmday) 36-200 10 a Oxazepam

(Serax, Serenid,

Serepax, Seresta) 4-15 20 a Prazepam

(Centrax, Lysanxia) [36-200] 10-20 a Quazepam (Doral) 25-100 20 h Temazepam

(Restoril, Normison,

Euhypnos) 8-22 20 h Triazolam

(Halcion) 2 0.5 h Non-benzodiazepines

with similar effects 1, 6 Zaleplon

(Sonata) 2 20 h Zolpidem

(Ambien, Stilnoct, Stilnox) 2 20 h Zopiclone

(Zimovane, Imovane) 5-6 15 h Eszopiclone

(Lunesta) 6

(9 in elderly) 3 h