One promise of the Trump Presidency is that it will try to break up Washington’s political cartels. Among the worst is the Education Department, and Betsy DeVos is well positioned to take it on as Mr. Trump’s nominee to run that wholly owned subsidiary of the teachers unions and cultural left.

Mrs. DeVos is a philanthropist who has devoted years and much of her fortune to promoting school reform, especially charter schools and vouchers. She chairs the American Federation for Children (AFC), which has fought in the trenches across the country for more school choice to liberate kids from failing schools. By trenches we mean hand-to-hand political combat in state legislative races against the teachers unions.

AFC was especially successful this year, as 108 of the 121 candidates it supported won their elections. AFC candidates in Florida won 20 of 21 targeted races. The group’s biggest coup was ousting a scourge of school choice in a Miami-Dade Senate district where Democrats are a majority. The teachers union dumped $1 million into the race but still lost.

The union hoped to demonstrate diminishing public support for Florida’s tax-credit scholarships—the largest private-school choice program in the country—which is under review by the state Supreme Court. AFC ran ads with parents of scholarship recipients demanding that opponents be held accountable.

Choice advocates scored other big victories this month in what is an underreported election story. Indiana Republican Jennifer McCormick dislodged State Education Superintendent Glenda Ritz, who attacked charters and vouchers during her four-year term. Republican Mark Johnson also defenestrated a union-backed superintendent in North Carolina.