Supreme Court Justice Antonin Scalia, 79, has died during a hunting vacation in Texas.

Scalia was the leading conservative voice on the court, and his death will set off a mammoth fight over who should replace him in the heat of a presidential election cycle.

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There is likely to be significant pressure on the Senate, which is in Republican hands, to hold off on confirming anyone nominated by President Obama, who is in his last year in office.

A spokesman for Sen. Mike Lee Michael (Mike) Shumway LeeMcConnell shores up GOP support for coronavirus package McConnell tries to unify GOP Davis: The Hall of Shame for GOP senators who remain silent on Donald Trump MORE (R-Utah), a conservative who sits on the Judiciary panel, immediately sent a message on Twitter stating that no nominee from Obama should be considered.

What is less than zero? The chances of Obama successfully appointing a Supreme Court Justice to replace Scalia? — Conn Carroll (@conncarroll) February 13, 2016

Several 2016 GOP White House hopefuls and Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellMcConnell focuses on confirming judicial nominees with COVID-19 talks stalled McConnell accuses Democrats of sowing division by 'downplaying progress' on election security Warren, Schumer introduce plan for next president to cancel ,000 in student debt MORE (R-Ky.) said the next president, not Obama, should select Scalia's replacement.

Democrats, including Senate Minority Leader Harry Reid Harry Mason ReidSenate Republicans signal openness to working with Biden Mellman: The likely voter sham Bottom line MORE (D-Nev.), called on the GOP-controlled Senate to consider an Obama nominee.

Said Senate Judiciary Committee ranking member Patrick Leahy Patrick Joseph LeahyBattle over timing complicates Democratic shutdown strategy Hillicon Valley: Russia 'amplifying' concerns around mail-in voting to undermine election | Facebook and Twitter take steps to limit Trump remarks on voting | Facebook to block political ads ahead of election Top Democrats press Trump to sanction Russian individuals over 2020 election interference efforts MORE (D-Vt.), "The American people deserve to have a fully functioning Supreme Court."

"The Supreme Court of the United States is too important to our democracy for it to be understaffed for partisan reasons," he said. "It is only February. The president and the Senate should get to work without delay to nominate, consider and confirm the next justice to serve on the Supreme Court.”

Replacing Scalia with a liberal justice could change the balance of the court under Chief Justice John Roberts, and would mean the election of the president could immediately determine the direction of the Supreme Court.

According to The National Review, it has been 80 years since a Supreme Court justice was confirmed in an election year to a vacancy that arose that year.

The Supreme Court is also likely to be a huge issue in November's race for the Senate majority. Individual senators running for reelection can be expected to see the court's makeup become a top issue in their campaigns.

Democrats need to gain five seats, or four seats if they retain the White House, to win back a Senate majority.

Republicans are defending several seats in states favorable to Democratic presidential candidates, including Wisconsin, Illinois and Pennsylvania. They are also defending seats in Florida, New Hampshire and Ohio, which were won in 2008 and 2012 by Obama.

A fight over the Senate filibuster is likely if the decision on Scalia's successor is punted to 2017. Sixty votes would be necessary to break a filibuster and confirm a Supreme Court justice.

Democrats used the "nuclear option" to change the Senate rules for most nominations so that only a majority vote was needed. But that did not apply to Supreme Court nominees.

Scalia's death comes on the day of the latest GOP presidential debate, the last time the candidates are set to meet before their Feb. 20 South Carolina primary. GOP candidates were quick to put out statements lauding Scalia, who has been a leading figure in the conservative movement for decades.

Two local news outlets first reported the news of Scalia's death, which the San Antonio News and KVIA said was from natural causes.

Roberts in a statement on behalf of all of the current and retired justices confirmed the news.

"I am saddened to report that our colleague Antonin Scalia has passed away," he wrote. "He was an extraordinary individual and jurist, admired and treasured by his colleagues. His passing is a great loss to the Court and the country he so loyally served. We extend our deepest condolences to his wife Maureen and his family."

Texas Gov. Greg Abbott (R) released a statement calling the conservative justice an "unwavering defender" of the Constitution.

"He was the solid rock who turned away so many attempts to depart from and distort the Constitution," Abbott wrote. "His fierce loyalty to the Constitution set an unmatched example, not just for judges and lawyers, but for all Americans."

Scalia, born in Trenton, N.J., and raised in Queens, N.Y., was nominated by Ronald Reagan in 1986 after serving on the D.C. Circuit Court.

He was a proponent of "originalism," the legal philosophy that held that the meaning of the Constitution should be interpreted as it was first written and not subject to contemporary views.

Scalia was also known for the colorful opinions he issued. In a dissent in King v. Burwell, the landmark healthcare case that upheld the Affordable Care Act, he referred to the majority's reasoning as "pure applesauce" and "jiggery-pokery."