A tiny south-west Queensland pub in a town with a population of two will open its doors on Christmas for neighbouring locals who are without family during the festive season.

The famous Toompine Hotel says it will serve Christmas lunch for residents from the surrounding district, including a few opal miners from nearby Duck Creek.

"There's a population of two - the bloke who owns it (the pub) and myself," said the pub's manager Sue Jones of the tiny town between Quilpie and Thargomindah.

Ms Jones says the isolation at Toompine makes opening on Christmas an important gesture.

"They've got nobody, so we just take them under our wing," she said.

"We have some local families that come that don't like to go away for Christmas.

"We play cards, we laugh, we do all the Christmas things that you do."

Ms Jones says she is expecting a good turnout at Toompine.

"For lunch we have chicken, pork, ham, turkey, beef - all the vegetables you can eat," she said.

"And then after that they have pudding and cream and fruit cake, ice cream. You name it, we've got it."