Clemson is preparing to play without Dexter Lawrence, the hulking defensive tackle and highly regarded NFL prospect who failed a drug test.

“For us, it’s like an injury, and I’ve spent zero time [thinking], ‘Oh, is he going to play. What’s the chance?’ ” defensive coordinator Brent Venables told reporters Wednesday.

Lawrence is not getting any defensive reps in practice, Venables said. He is one of three Clemson players, along with tight end Braden Galloway and offensive lineman Zach Giella, who may not be available for Saturday’s College Football Playoff semifinal against Notre Dame at AT&T Stadium. The three failed drug tests that revealed trace amounts of ostarine, a performance-enhancing drug. Clemson is hoping a B sample will clear the players.

But for now, the 6-foot-4, 350-pound Lawrence, who had 44 tackles, 7.5 for losses and 1.5 sacks this year, may not be available. Venables said he would be replaced in the starting lineup by senior Albert Huggins and sophomore Nyles Pinckney would also see plenty of action.

“I hate talking about it. You hurt for a guy that’s your brother,” defensive end Clelin Ferrell said. “There’s still a lot to be said about that situation. You hurt for him, but as a leader and as his teammate, you’ve really just got to do what’s best for the team and move on.”

According to a report by Stadium’s Brett McMurphy, Notre Dame quarterback Brandon Wimbush plans to transfer at the conclusion of this season after losing his starting job to Ian Book. But he remains with the team for the time being. As a graduate transfer, Wimbush would be eligible immediately.

“I would bet he’s a little bit upset because he’s such a team guy and doesn’t want any attention on him or anything taken away from the team,” wide receiver Miles Boykin said.

Wimbush, a Teaneck, N.J. native, led Notre Dame to 10 victories a year ago, before he was replaced by Book after three games this season. He did play well in a 42-13 victory over Florida State on Nov. 10, throwing three touchdown passes, when Book was sidelined with a rib injury.

“I love that kid. We’ve always told him: Whatever you decide to do, we’re with you 100 percent,” offensive coordinator Chip Long said. “To have your job taken away but come out and beat Florida State by [29] points, it’s a testament to him.”