TUSCALOOSA, Ala. -- Neither Florida's defense nor Alabama's mistakes could contain Blake Sims and Amari Cooper.

Sims threw for 445 yards, the second-best passing performance in school history, and Cooper scored three touchdowns as the third-ranked Crimson Tide overcame a sloppy performance to beat the Gators 42-21 on Saturday.

The Tide (4-0, 1-0 Southeastern Conference) committed 11 penalties for 80 yards and four turnovers that turned into 21 points for the Gators (2-1, 1-1), who still couldn't handle Sims and the prolific passing connection.

Sims threw touchdown passes of 87 yards to Kenyan Drake on the opening play and 79 to Cooper later in the first quarter. Still, 400 yards for an Alabama offense known more in the past for bruising running games?

"I didn't think it was possible," Sims said. "I just try to take what I take and what the defense gives me, and just try to trust my guys that they're going to be there."

Cooper, who came in leading the nation in receptions, caught 10 passes for 201 yards and three touchdowns. He broke Dennis Homan's 47-year-old record of 18 career touchdown catches.

The Tide's turnovers and miscues kept the game close into the fourth quarter. Alabama's 645 total yards was the most the Gators have allowed.

The previous high was Nebraska's 629 yards in the 1996 Fiesta Bowl. Sims was 23-of-33 passing with four touchdowns, and was already up to 335 by halftime. That placed him a yard shy of the Tide's Top 10 passing games.

"People have to respect his passing," Tide coach Nick Saban said. "He has made too many plays for people not to respect him as a passer."

Derrick Henry gained 111 yards on 20 rushes.

Sims deflected much of the credit, saying that when you have Alabama's offensive line, receivers and tailbacks, "You're bound to have a good game."

The Gators' offense wasn't much more successful than its defense.

Cooper Sets Record With his three touchdown receptions Saturday, Amari Cooper set an Alabama record for most career receiving touchdowns with 20. Player Rec TDs 2012-14 Amari Cooper 20* 1965-67 Dennis Homan 18 2004-07 DJ Hall 17 1974-77 Ozzie Newsome 16 *3 Saturday vs. Florida --ESPN Stats & Information

Florida's Jeff Driskel was harassed and ineffective passing. He was 9-of-28 passing for 93 yards and was intercepted twice while the offense produced just 200 yards.

Driskel did run for 59 yards, but it got so bad that Florida legend Emmitt Smith called for the quarterback's benching on Twitter.

Demarcus Robinson, who had 15 catches in an overtime win over Kentucky, was held to two receptions for 14 yards.

Florida failed in its bid for a statement-making performance after a 4-8 season and to perhaps lift coach Will Muschamp, whose mentor Saban was on the opposite sideline, from the hot seat. The Tide's blunders kept the game from being even more lopsided.

"We had our chances and we didn't do it," Muschamp said. "That's the frustrating thing."

It was all Alabama after Driskel's 14-yard touchdown run tied the game at 21-21 early in the third quarter. That came two plays after Neiron Ball got his left hand on a Sims throw at the line and Antonio Morrison scooped it up for a 20-yard return. All three of the Gators' touchdowns came after turnovers.

"Obviously everybody that watched the game could tell that there were some things that we did extremely well and some things (that) were pretty sloppy," Saban said. "But I thought in the second half we really controlled the game."

Alabama answered the tying score with a 16-play drive sustained despite two penalties and a sack. Henry dodged a couple of defenders for a 29-yard catch on third-and-23 and scored on a 3-yard run on the next play with 5:27 left in the third quarter.

"We didn't make the plays and they did," Driskel said. "We didn't get it done. It's a matter of execution.

"It was a game of big plays. Alabama had a lot more than us."

The Tide did get a scare when Sims went to the locker room after getting hurt on a 24-yard run late in the third quarter. He appeared to be clutching his right shoulder on the sideline but played again.

Sims returned shortly after backup Jake Coker hit Cooper for a 4-yard touchdown and received a big ovation as he sprinted across the field to the sideline and congratulated Coker with Alabama having just extended its lead to 35-21.

Saban said Sims had a bruised right shoulder, but the Tide has an open date next week to heal.