Lane Johnson

Philadelphia Eagles' Lane Johnson is seen during an NFL football game against the Pittsburgh Steelers . Sunday, Sept. 25, 2016, in Philadelphia. (AP Photo/Michael Perez)

(Michael Perez)

Coming off of their first loss of the season, the Eagles have now also lost their starting right tackle for the next 10 games.

After just over a month of speculation and waiting, Eagles offensive tackle Lane Johnson was suspended 10 games for a failed PED test this past summer, as first reported by MMQB's Albert Breer.

Per lawyer Steve Zashin, Eagles OT Lane Johnson has been informed his 10-game suspension has been upheld. — Albert Breer (@AlbertBreer) October 11, 2016

Breer's report was confirmed by the NFL in a statement released through the Eagles:

"Lane Johnson of the Philadelphia Eagles has been suspended without pay for the team's next 10 games for violating the NFL policy on performance enhancing substances.

"Johnson's suspension begins immediately. He will be eligible to return to the Eagles' active roster on Monday, December 19 following the team's December 18 game against the Baltimore Ravens."

The Eagles press release also included a statement Executive Vice President of Football Operations Howie Roseman:

"We're very disappointed that Lane Johnson has been suspended 10 games. His actions have affected the entire organization.

"We are all working under a clearly-defined set of rules and regulations set forth by the NFL in the collective bargaining agreement with the NFLPA.

"Moving forward, he has no choice but to hold himself accountable to Jeffrey Lurie, Coach Pederson and his staff, his teammates, and to the entire organization and our fans.

"When he returns from suspension, we will continue to support him and welcome him back to the team.

"We are moving on with our preparations for this week's game in Washington."

Here is a statement from Johnson's lawyer on the appeal being denied, per Breer:

Here is a statement from Lane Johnson's outside counsel on the NFL's decision ... pic.twitter.com/pvpZLlYoRb — Albert Breer (@AlbertBreer) October 11, 2016

Johnson won't be able to play until the team's Week 16 Thursday Night game against the New York Giants.

Johnson originally tested positive for a PED this past summer, but was awaiting the return of both his B sample and a decision on his appeal.

While waiting, Johnson has been able to suit up and play in the Eagles' first four games, and has been playing some of the best football of his career.

The team is a surprising 3-1, due in large part to the protection the offensive line has been able to give rookie quarterback Carson Wentz.

With Johnson now gone for 10 games, the Eagles will have to re-shuffle their offensive line. The team has a few options, including moving starting offensive guard Allen Barbre to tackle, and starting either veteran Stefen Wisniewski or rookie Isaac Seumalo.

If they decide to keep Barbre at guard, they could start rookie Halapoulivaati Vaitai at offensive tackle, but it would be fair to wonder if he is ready. Another option would be Matt Tobin.

Whatever the Eagles end up doing, however, the fact that they have now lost Johnson is the first major issue this team has had to deal with since starting the season -- and could end up really impacting the offense.

As for Johnson, he is now forced to stay away from the NovaCare Complex for the next 10 week.

"[I'll] stay in shape and hopefully the team is good enough to stay in playoff contention," Johnson said after the loss to the Detroit Lion. "Come back and I'll be fresh and we can make a run for it."

THE NO-HUDDLE SHOW, E49: The Eagles lose a game, then Lane Johnson

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Eliot Shorr-Parks may be reached at eshorrpa@njadvancemedia.com. Follow him on Twitter @EliotShorrParks. Find NJ.com Sports on Facebook.