ZURICH — Swiss authorities began a new series of pre-dawn arrests Thursday in the broad investigation, led by United States officials, into corruption in international soccer. Sixteen people were expected to be charged by day’s end, law enforcement officials said, nearly doubling the size of an already huge case that has upended FIFA, soccer’s multibillion-dollar governing body.

Some of the arrests took place at the same luxury hotel where other FIFA officials were arrested in May. Swiss police entered the hotel, the Baur au Lac, through a side door at 6 a.m. local time. A hotel manager told visitors in the lobby they had to leave the property because of “an extreme situation.”

The police were targeting current and former senior soccer officials on charges that include racketeering, money laundering and fraud, authorities said. The new charges were expected to hit South and Central American soccer leaders particularly hard, the officials said.

The Justice Department confirmed in a news release that Alfredo Hawit of Honduras and Juan Ángel Napout of Paraguay were among those charged. Mr. Hawit is the president of Concacaf, the regional confederation that includes North and Central America and the Caribbean. Mr. Napout is the president of Conmebol, the South American confederation. Both are FIFA vice presidents and members of the organization’s governing executive committee.