A woman has been charged with the murder of her husband, while their four-year-old son was in the house, following a domestic dispute in Brisbane's west.

Police said a 35-year-man was stabbed in the chest at his home on Fig Tree Pocket Road at Chapel Hill about 9:00pm on Wednesday.

He received medical treatment at the house but died a short time later in hospital.

The man's 36-year-old wife is in custody and will appear in Brisbane's Magistrates Court this morning charged with one count of murder.

Police said the couple's four-year-old son was at home but had not witnessed the incident.

The boy is now in the care of relatives.

Neighbour Ellen Shanahan said the news had been a shock.

"Couldn't have woken to more of a shock … nobody in the neighbourhood can make sense of what's happened overnight," she said.

Ms Shanahan said she had not known the man's wife at all, and she had only had occasional contact with the man.

"I know him as a neighbour ... very personable man, very hardworking man, just quiet about himself," she said.

"I don't hang out with him so I could not make a 100 per cent character assumption but my interactions with him have been very pleasant.

"Friendly — that's the best way I can describe — friendly, personable, just kind-hearted I guess."

The home has been declared a crime scene and investigations are ongoing.