"Insatiable" tells the story of Patty (played by Ryan), a teenager bullied at her high school for the way she looks. In the newly released trailer, other students refer to Ryan's character as "Fatty Patty" and post pictures of her face on a pig's body on her locker.

One summer, Patty gets her jaw wired shut, loses weight and comes back to school looking unrecognizable and conventionally attractive. She decides she can join any clique in the school but instead wants revenge on her bullies. Patty is coached by failed attorney Bob Armstrong (played by Dallas Roberts), whose true aspiration is to coach pageant queens. Milano plays Bob's wife, Kimmy Shields.

The show's tagline bills the series as, "A coming of rage story."

On Saturday, Ryan posted a long statement on Twitter saying that she was excited to work on "Insatiable" because the series tackles the shame women feel about their bodies through satire and "enter difficult conversations."

"Twelve years after my own struggles with body image ... I was drawn to this show's willingness to go to real places about how difficult and scary it can be to move through the world in a body, whether you're being praised or criticized for its size, and what it feels like to pray to be ignored because it's easier than being seen," Ryan wrote.