GREEN BAY, Wis. -- Clay Matthews might not be coming back to save the Green Bay Packers' pass rush anytime soon.

The Pro Bowl outside linebacker, who missed his second straight game in Sunday's loss to the Indianapolis Colts, had a setback with his ailing hamstring last Friday -- one day after he declared himself ready to return.

"Clay looked good in practice Thursday [but] had a setback and was unable to play," Packers coach Mike McCarthy said Monday. "His status for this week, I'm not ready to get into that because I haven't had the meeting with the trainers."

Clay Matthews' status is up in the air after he suffered a setback to his injured hamstring. AP Photo/Morry Gash

Matthews, who also missed the Week 3 game against Detroit because of the same hamstring injury, has three sacks in his five games this season.

Without Matthews each of the past two games, the Packers have recorded just four sacks combined. Both sacks Sunday against Andrew Luck came on safety blitzes, with Ha Ha Clinton-Dix combining with linebacker Nick Perry for one and Morgan Burnett getting the other.

Defensive coordinator Dom Capers blitzed Luck often on Sunday, and it worked until the final drive. Capers blitzed on all four of Luck's passes, allowing three completions (including the two third-down conversions that sealed the game). Before that last drive, Luck was just 8-of-15 with two interceptions against the blitz, according to ESPN Stats & Information.

Heading into Sunday's game, Matthews seemed more likely to play with his hamstring injury than receiver Randall Cobb with his. However, Cobb was a last-minute addition to the active list and used sparingly. He did not play at all in the first half, but with the Packers down by two touchdowns at halftime, McCarthy put Cobb on the field for 23 second-half snaps.

Cobb caught two passes for 14 yards, including a 3-yard touchdown that pulled the Packers to within five points with 3:29 remaining.

Cobb appeared to make it through the game without a setback.

"I know as of last night he felt that he came out of the game just as good as he went in," McCarthy said Monday. "I have not met with the trainers yet today, so I think we're moving forward in Randall's case."