A gunman is on the run after reportedly shooting a man in the face in Point Cook in the city's south-west overnight.

The shooting occurred at a house on Spraypoint Drive in Sanctuary Lakes just before 11pm on Thursday.

Police have been told that the victim, a 53-year-old Point Cook man, was shot by an unknown person who fled the scene before police arrived.

One resident, who went to the aid of the victim, said the man had been"shot in the face."

"Yelling came on and then a gunshot...there were a few people involved," the man, who did not want to be identified, told radio station 3AW.