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Well, depending on exactly the load at the muzzle a 12 gauge shotgun generates something in the neighborhood of 2,500 foot pounds of energy give or take. With that much energy, virtually regardless of what the load is you will have a shot go all the way through a human target.

12 gauge shotgun slug has a diameter of about .73 inches, or almost 3/4 of an inch. Not too many ways to survive a through and through hole augered through your chest at that diameter.

A 3 1/2" magnum 00 buck shell has between 9 - 15 00 buck pellets in it at .33 inches diameter per. Again at point blank range all are going through. So now you are looking at an aggregate of at least a 3" hole (9 x .33) and something like a 5" (15 x .33) hole max.

Step back and think about that for a minute.

A 5" hole is something that you could put your clenched fist through and for most people have clearance all the way around. A 3" hole you can get 4 fingers into the hole to 2nd knuckle on most people before you touch skin anywhere.

So, to close a long answer to your question ... the load you are talking about is not going to be any more effective than a standard 00 buck load.

In fact, because of the total quantity of different bits of stuff you want to stick in the shell it will arguably be less. Remember, you have a fixed amount of energy which is propelling all of this. So, the more items that the energy is divided up between the less each one of them has. This is why fine bird shot has much less range than buck shot, which has less range than a slug because the energy is spread over more projectiles.

Now, at point blank, it isn't really going to matter.

As an aside, gently, remember this - professional ammunition people get paid good money to develop defensive loads for use by people who have crazed armed armored felons as part of their typical scenarios. Further, those special ops sort of groups, whether in police, military or private, will pay a premium (check the price of defense loads in anything compared to range loads) for those sorts of rounds.

If you are asking us about the effectiveness of a round which you are jigging up, what do you think the odds are that you know more than the people who design this stuff for a living in a really competative market?

Thinkingblade