Four police cars have been trashed and an apartment has been damaged after an out-of-control party in North Melbourne overnight.

Multiple noise complaints were made to authorities about a holiday rental apartment on Shands Lane about 2am.

Up to 50 youths were found at the scene; when officers told the group to disperse, carnage erupted.

Four cars sustained serious damage. (9NEWS) (9news)

Investigations are now underway. (9NEWS) (9news)

As officers tried to evict partygoers from inside the unit, other youths began pelting the patrol cars with wood and jumping on the bonnets.

"There was a lot of screaming and shouting, banging and smashing," local man Alex Simpson told 9NEWS.

Images of the aftermath show the police cars with significant damage to the windscreen, along with broken side mirrors and muddy footprints on the front of the vehicles.

Some of the party attendees were still at the property. (9NEWS) (9NEWS)

The unit itself also sustained significant damage, with plaster walls kicked in and a television and microwave stolen.

"It's outrageous, it's criminal behaviour and it's not something we tolerate," Senior Sergeant Adam Turner said.

No one was injured during the ordeal, and no arrests have been made.

Locals have said it is the second time in as many weeks the property has been damaged.

Up to 50 youths were at the party. (9NEWS) (9news)

Investigations are ongoing.

Anyone with information is urged to contact Crime Stoppers on 1800 333 000