A man has left a trail of destruction after crashing his luxury sports car into four parked vehicles, a tree and a brick wall in the Perth suburb of Attadale.

The man was driving a high-powered, black Audi R8 when he crashed into two parked cars in Kingsall Road last night.

His car lost a right-front wheel, but continued down the street and hit another two vehicles, including a four-wheel drive with enough impact to make it roll onto its side.

His vehicle stopped after crashing into a brick wall.

Police said they believed the man was drunk, but are waiting on the outcome of a blood test to confirm it, after the driver allegedly refused a breath test.

They said if the man does return a positive test, he will not be covered by insurance and will be liable for all the damage, including to his vehicle, which is believed to be worth more than $150,000.

The total damage bill, which includes the other four cars and a brick garden wall, could stretch into the hundreds of thousands of dollars.

Jo Crew, a nurse who lives in Kingsall Road, said the car crashed into two vehicles belonging to her children, who are university students, at the front of her home.

"We woke up to a huge crashing noise," she said.

"We came outside and he'd cleaned up two of the cars, my two children's cars at the front.

A four-wheel drive was knocked over in the multi-car crash. ( Supplied )

"We thought the car had taken off, until we saw that there was a wheel halfway down the road and realised he couldn't have got any further, so we kept running down the road and found him.

"He [had] taken out a wall, flipped a four-wheel drive and was in the car, so I just administered first aid and called the ambulance.

"He was unconscious and had a lot of blood on his face with lacerations, but he was breathing."

She said the incident had left her feeling "horrible" and her family shaken.

Peter Quick, who is visiting from Queensland, said his hire car was damaged in the crash.

"We were in bed and we just heard a crash coming down the street and it ended up out the front," he said.

"We didn't get to sleep until about 3:00am, very distressed.

"I've got to go and tell the hire company now."

The driver of the Audi, a 30-year-old Winthrop man, was taken to Fiona Stanley Hospital.