A police gun is missing after it fell from an male officer's holster south of Brisbane.

Police said the weapon became dislodged during an incident in Woodridge about 12.40pm on Wembley Road, near the intersection of Mayes Avenue.

Fairfax Media understands the officer was chasing an offender on foot when the gun fell out of its holster.

The weapon has not been found despite extensive searches, police said.