Funding from the US National Institutes of Health (NIH) (grant nos. R01DK096075, R01DK107875 and R01DK114506) and the Department of Defense (contract no. RTRP W81XWH-17-1-0680) are gratefully acknowledged. We thank Sylvatica Biotech, Inc. and are grateful for support through the NIH (grant no. R21EB023031) and the US Army MRDC (contract no. W81XWH-16-C-0067). R.J.V. acknowledges a stipend from the Michael van Vloten Fund for Surgical Research. S.N.T. acknowledges support from NIH grant no. K99 HL143149. We thank M. Karabacak, Y.M. Yu and F. Lin at the Mass Spectrometry Core Facility (Shriners Hospital for Children, Boston, MA) for assistance with adenylate quantification. We thank L. Burlage, A. Matton, B. Bruinsma and C. Pendexter for experimental assistance. Finally, appreciation is extended to LiveOnNY, and we are especially grateful for our collaboration with New England Donor Services and their generous support that enables research with human donor organs. The views, opinions and/or findings contained in this manuscript are those of the authors and should not be construed as an official position, policy or decision of any of the institutions that supported the research, unless so designated by other documentation.