Rare comic books worth thousands of dollars are feared destroyed after fire ripped through a Brisbane shop overnight.

Five fire crews were called to Comic Empire on Logan Road in Greenslopes on Brisbane's southside

just after midnight on Thursday.

Comic Empire manager Tony Nasser at his fire-ravaged shop. Credit:Toby Crockford

They found the shop "filled with smoke" and extinguished the flames just after 12.30am.

The store shares the commercial unit with a newsagency, but firefighters contained the flames to the comic store and the newsagency was not damaged.