Is Nathaniel Clyne ready to swap St Mary's for Old Trafford? Laurence Griffiths/Getty Images

Southampton defender Nathaniel Clyne is set to reject the Saints' offer of a new deal as he holds out for a move to Manchester United, sources have told ESPN FC.

Clyne's future has been the subject of speculation for some time with the full-back's contract at St Mary's due to expire next summer.

Southampton are determined to keep the 23-year-old and sources say they have offered the defender a new lucrative deal in the region of £45,000 a week.

However, Clyne is ready to snub the offer of a new deal as he has his heart set on a switch to Old Trafford.

Clyne has established himself as one of the best right-backs in the Premier League and his form this season saw him break into Roy Hodgson's England squad, making his debut in the Euro 2016 qualifier win over Slovenia.

Manchester United boss Louis van Gaal is keen to bring in a new right-back this summer with Rafael currently out of favour and Antonio Valencia being played as a full-back rather than a winger for most of the season.

A host of right-backs, including Barcelona's Dani Alves and Porto's Danilo have been linked with a move to Manchester United, but Clyne is reportedly at the top of Van Gaal's wish list.

Chelsea are interested in Clyne, but sources say the former Crystal Palace man favours a move to Old Trafford, despite turning United down in favour of a move to Southampton in the summer of 2012.