HINDMAN, KY. — The heritage of handcrafted stringed instruments runs deep in this tiny Appalachian village (pop. 770) stretched along the banks of Troublesome Creek. The community has been known as the homeplace of the mountain dulcimer ever since a revered maker, James Edward (“Uncle Ed”) Thomas, pushed a cartload of angelic-sounding dulcimers up and down the creek roads, keeping a chair handy to play tunes for passers-by.

Music is the region’s lifeblood: Locals like to say that “you can toss a rock and hit a musician.” But these strong cultural roots have been tested by the scourges that devastated Eastern Kentucky, an early epicenter of the opioid crisis. Hindman is the seat of Knott County, one of the poorest regions in the United States and one that continues to grapple with overdose death rates that are twice the national average. It is also in the top 5 percent of counties most vulnerable to the rapid spread of H.I.V. and hepatitis C, according to the Centers for Disease Control and Prevention. The decline of the coal industry has brought even more economic hardship to these isolated hills and hollows — providing fertile ground for Appalachia’s signature epidemic.

But last year, an unlikely group of renegades — suspender-wearing luthiers from the Appalachian Artisan Center here — embarked on a novel approach to the hopelessness of addiction called Culture of Recovery, an apprentice program for young adults rebounding from the insidious treadmill of opioids and other substances. Participants, about 150 so far, learn traditional arts like luthiery — the making and repairing of stringed instruments — under the tutelage of skilled artisans. They come to the program through a partnership between the Artisan Center; a local residential rehab center for men, and the Knott County Drug Court, which is just down the block from the Appalachian School of Luthiery.