Simcha Rotem, an Israeli Holocaust survivor who was among the last-known Jewish fighters from the 1943 Warsaw ghetto uprising against the Nazis, has died. He was 94.

Rotem, who used the underground nickname Kazik, took part in the single greatest act of Jewish resistance during the Holocaust. Though destined to fail, the Warsaw ghetto uprising symbolised a refusal to succumb to Nazi atrocities and inspired other resistance campaigns by Jews and non-Jews alike.

Rotem, who died on Saturday after a long illness, helped save the last survivors of the uprising by smuggling them out of the burning ghetto through sewers. The Jewish fighters fought for nearly a month, fortifying themselves in bunkers and managing to kill 16 Nazis and wound nearly 100.

“This is a loss of a special character since Kazik was a real fighter, in the true sense of the word,” said Avner Shalev, the chairman of the Yad Vashem Holocaust memorial in Jerusalem. “The challenge for all of us now is to continue giving meaning to remembrance without exemplary figures like Kazik.”

Rotem was born in 1924 in Warsaw, at a time when its vibrant Jewish community made up a third of the city’s population. During the second world war, he was wounded in a German bombing campaign that destroyed his family home. His brother and five other close relatives were killed. Shortly after, the city’s Jews were herded into the ghetto.

The ghetto initially held 380,000 Jews and at its peak housed about a half million. Life in the ghetto included cramped conditions, random raids, confiscations and abductions. Disease and starvation were rampant.

The resistance movement began to grow after the deportation of 22 July 1942, when 265,000 men, women and children were rounded up and later killed at the Treblinka death camp. As word of the genocide spread, those who remained behind no longer believed German promises that they would be sent to forced labour camps.

A small group of rebels began to spread calls for resistance, carrying out isolated acts of sabotage and attacks. Some Jews began defying German orders to report for deportation.

The Nazis entered the ghetto on 19 April 1943, the eve of the Passover holiday. They set it ablaze three days later, turning it into a fiery death trap, but the Jewish fighters kept up their struggle for nearly a month before they were suppressed.

The teenage Rotem served as a liaison between the bunkers and took part in the fighting, before arranging for the escape of the few who did not join the revolt’s leader, Mordechai Anielewicz, in the command bunker on 18 Mila Street for the final stand.

The Nazis and their collaborators ultimately killed 6 million Jews before the Allies’ victory brought an end to the Holocaust.

After the war, Rotem emigrated to pre-state Israel and fought in its war of independence. He was later an active speaker and member of the Yad Vashem committee responsible for selecting the Righteous Among the Nations, non-Jews who risked their lives to save Jews during the Holocaust. On the revolt’s 70th anniversary in 2013, he was honoured by Poland for his role in the war.

“Kazik fought the Nazis, saved Jews, immigrated to Israel after the Holocaust, and told the story of his heroism to thousands of Israelis,” the Israeli prime minister, Benjamin Netanyahu, said. “His story and the story of the uprising will forever be with our people.”

Rotem is survived by his two children and five grandchildren.

After his death, there is only a single known remaining Warsaw ghetto uprising survivor left in Israel – 89-year-old Aliza Vitis-Shomron. Her main task had been distributing leaflets in the ghetto before she was ordered to escape and tell the world of the Jews’ heroic battle.