City’s best run in the Champions League was reaching the semifinals in 2016, losing by 1-0 over two legs against Madrid. That was soon after Zidane took over in Madrid, and just before Guardiola was hired to replace Manuel Pellegrini in Manchester.

Also, Liverpool was sent back to the Spanish stadium where it won the title last season. The first leg against Atlético de Madrid will be at the Metropolitano Stadium on Feb. 18.

“I think that Liverpool know the stadium very well,” said Atlético’s director, Clemente Villaverde, who described Liverpool, the unbeaten Premier League leader, as “at this moment the best team we have in Europe.”

Liverpool Coach Jürgen Klopp said there were “pretty much four or five potential finals already in the last 16.”

Barcelona, the Spanish league leader, will face Napoli with the first leg in Italy, and Chelsea will face Bayern Munich in a rematch of the 2012 final. Chelsea won that title in Bayern’s home stadium, which will host the second leg on March 18.