Rest assured Queensland, the fire that broke out at Brisbane's landmark XXXX brewery will not affect beer supply.

More than 40 firefighters were called to the Milton Road brewery after thick black smoke was seen billowing from the building just after 5pm on Tuesday.

Smoke could be seen billowing from the brewery on Tuesday afternoon. Credit:Twitter / Cameron Thompson

Roads around the inner-city brewery were closed during peak hour as crews battled the blaze, which caused a traffic nightmare for motorists.

Pedestrians were stopped from walking along Milton Road and police were called in to control traffic that had backed up to Caxton Street.