Posted 16 April 2017 - 11:08 PM

Purpose: to increase mito fission or fusion for specific goals

Background: The average cell contains some one thousand mitochondria, each which contains several identical loops of mtDNA. These mitochondria are in a dynamic flux of fission and fusion, which serves to scramble the mtDNA and other mito components. This is important in maintaining a healthy population.

See: Mechanisms of Mitochondrial Fission and Fusion and Nicotinamide-induced Mitophagy

Supplements for fission: These are NAD+ precursors, and appear to be effective in this sequence: niacin < nicotinamide < NR < (nicotinamide + ribose)

Supplement for fusion: C18:0 — stearic acid.

See: Regulation of mitochondrial morphology and function by Stearoylation of TfR1 — “We find that animal cells are poised to respond to both increases and decreases in C18:0 levels, with increased C18:0 dietary intake boosting mitochondrial fusion in vivo.”

Small mitochondria are less efficient and any problem with the mtDNA genes can be detected by the cell via the membrane potential, which marks the mitochondrion for mitophagy. Thus pushing the balance of fission and fusion in the direction of fission can clean up the population of mitochondria, and can be also used for enhancing exercise.

See my thread Exercise Like a Girl for a method of combining fission with exercise to both improve the efficiency of exercise and improve the population of mitochondria. (For some reason this thread is locked, and even I can’t post to it. So anyone wanting to discuss that here is welcome to do so.)

Large mitochondria are more efficient. I’ve notice that using supplements that push mitochondria to smaller size don't work well with C60 (and in fact can be terrible) thus I wondered if pushing it in the other direction might make C60 more effective. I’ve tried this a few times, using C60 (in MCT oil: 1-2 mg C60 and a like amount of hydroxytyrosol), and it does seem to be more effective when combined with several grams of stearic acid. At least, I’m seeing hair regrowth that I haven’t seen since I first tried C60 in olive oil five years ago.

Edited by Turnbuckle, 16 April 2017 - 11:21 PM.