One person has been charged with manslaughter after a man was killed during a fight involving five or six people at Front Street East and Market Street on Monday night, Toronto police say.

Levon Jolen Gammon, 43, of no fixed address, has been charged with manslaughter, and was scheduled to appear in a Toronto court on Tuesday afternoon.

The victim has been identified as Paul Crombie, of no fixed address. The 50 year-old man suffered a "significant head injury" during the altercation and was rushed to hospital without vital signs, where he was pronounced dead.

Toronto police Insp. Steve Molyneaux told reporters last night that says the homicide unit is investigating.

"I can tell you that we did receive a radio call around 9:30. At this point, it's too early to discuss exactly what happened. It is still under investigation. We have several people we need to speak to."

Insp. Steve Molyneaux says police are questioning several people in relation to the altercation. (CBC)

Another man was taken to hospital with unknown injuries.

Forensic teams were on the scene in the pedestrian walkway around the Rainbow Cinemas Market Square where the fight occurred for some time on Monday night, canvassing for information.

Police have surveillance footage from the area and they are also speaking with several witnesses.

Anyone with information is asked to contact police at 416-808-7400 or Crime Stoppers anonymously at 416-222-TIPS.