Dr. Mermod:

The first bottleneck is transcription of the transgene. We have been working on the element called MAR, which can remove some of the negative effects of integration of the transgene into a non-favorable genetic environment. And other people are also working on other elements. That – for the MAR elements –allows to, pretty much, dampen some silencing effects and also to prevent oscillation of transcription, whereby you get the transgene active at all times within all cells.