The campaign arm of Senate Democrats launched its first paid advertisement Tuesday, aiming to tie vulnerable Republican incumbents and upstart Senate challengers to GOP presidential front-runner Donald Trump Donald John TrumpObama calls on Senate not to fill Ginsburg's vacancy until after election Planned Parenthood: 'The fate of our rights' depends on Ginsburg replacement Progressive group to spend M in ad campaign on Supreme Court vacancy MORE.

The Democratic Senatorial Campaign Committee (DSCC) ad intersperses clips of some of Trump’s incendiary remarks — with a lot of foul language bleeped out — with clips of incumbents and House members running for Senate saying they’ll support Trump if he’s the party’s nominee.

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Among those who make an appearance: Sens. John McCain John Sidney McCainMcSally says current Senate should vote on Trump nominee Say what you will about the presidential candidates, as long as it isn't 'They're too old' The electoral reality that the media ignores MORE (Ariz.), Rob Portman Robert (Rob) Jones PortmanRomney undecided on authorizing subpoenas for GOP Obama-era probes Congress needs to prioritize government digital service delivery House passes B bill to boost Postal Service MORE (Ohio), Kelly Ayotte Kelly Ann AyotteBottom line Bottom line Bottom Line MORE (N.H.), Richard Burr Richard Mauze BurrRep. Mark Walker says he's been contacted about Liberty University vacancy Overnight Defense: Trump rejects major cut to military health care | Senate report says Trump campaign's Russia contacts posed 'grave' threat Senate report describes closer ties between 2016 Trump campaign, Russia MORE (N.C.), Mark Kirk Mark Steven KirkLiberal veterans group urges Biden to name Duckworth VP On the Trail: Senate GOP hopefuls tie themselves to Trump Biden campaign releases video to explain 'what really happened in Ukraine' MORE (Ill.), Pat Toomey (Pa.), Roy Blunt Roy Dean BluntCDC tells Congress it urgently needs billion for vaccine distribution On The Money: Trump undercuts GOP, calls for bigger COVID-19 relief package | Communities of color hit hardest financially by COVID-19 | Businesses, states pass on Trump payroll tax deferral Trump undercuts GOP, calls for bigger COVID-19 relief package MORE (Mo.), and Ron Johnson Ronald (Ron) Harold JohnsonThe Hill's Morning Report - Sponsored by The Air Line Pilots Association - White House moves closer to Pelosi on virus relief bill Second GOP senator to quarantine after exposure to coronavirus GOP-led panel to hear from former official who said Burisma was not a factor in US policy MORE (Wis.).

Portman, Ayotte, Kirk, Toomey and Johnson all face tough reelection prospects in a presidential year, when turnout could favor Democrats. Kirk and Johnson are the most endangered of the bunch, while Portman, Ayotte and Toomey are running in hotly contested swing states.

Also in the ad are Reps. Joe Heck (Nev.), who is running for the seat being vacated by Sen. Harry Reid Harry Mason ReidSenate Republicans signal openness to working with Biden Mellman: The likely voter sham Bottom line MORE (D-Nev.), and David Jolly (Fla.) and Ron DeSantis (Fla.), who are in a crowded primary running for the seat being vacated by Sen. Marco Rubio Marco Antonio RubioFlorida senators pushing to keep Daylight Savings Time during pandemic Hillicon Valley: DOJ indicts Chinese, Malaysian hackers accused of targeting over 100 organizations | GOP senators raise concerns over Oracle-TikTok deal | QAnon awareness jumps in new poll Intelligence chief says Congress will get some in-person election security briefings MORE (Fla.).

“Republicans running for U.S. Senate, running with Trump,” text from the ad states.

It then cuts to Trump saying: “What the hell are we doing?”

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“Exactly,” the ad concludes.

The DSCC says the ad is the first in what will be a “sustained campaign” across television, radio and social media meant to tie Republicans running for Senate to the controversial GOP front-runner.

Democrats have a good chance of taking back the Senate in 2016 after losing their majority in the last cycle.

Republicans are defending 24 seats, compared to only 10 for Democrats. If Democrats net five seats, they’ll win back the Senate.

Many Republicans up for reelection are running in states President Obama carried in 2008 or 2012.