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In 2014, I interviewed a number of moms from across the country who were fighting to get access to a form of cannabis oil that they believed would help their children’s seizures. They had an uphill battle in lobbying conservative legislatures to allow them to import the oil and in convincing their own doctors to try the experimental treatment. Many ended up going to Colorado, where there is a small community of growers, medical practitioners and researchers willing to work with them.

Their work may have finally paid off.

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GW Pharmaceuticals announced Monday that the first of its four major studies of the cannabis-based drug appeared to dramatically reduce seizures in patients with Dravet syndrome, a rare and severe form of epilepsy.

“This shows that cannabinoids can produce compelling and clinical important data and represent a highly promising new class of medications, hopefully in a range of conditions,” Justin Gover, GW Pharmaceuticals’ chief executive, told Reuters.