A meth drug lab described as "one of the largest" ever found in South Australia has been discovered by police in Adelaide's south and two men have appeared in court to face charges over it.

Key points: Powder and the drug ice allegedly found at a home

Powder and the drug ice allegedly found at a home Police say it was "one of the largest" meth labs ever discovered

Police say it was "one of the largest" meth labs ever discovered Two men have been arrested

Police searched a house at Morphett Vale on Sunday and said they found a laboratory, about 120 kilograms of powder — suspected of being methamphetamine — and 11 kilograms of what police believe to be crystal methamphetamine, also known as the drug "ice".

The suspected methamphetamine was allegedly undergoing a "manufacturing process".

Members of the Serious and Organised Crime Branch and STAR Group officers took part in the search.

Space to play or pause, M to mute, left and right arrows to seek, up and down arrows for volume. Watch Duration: 1 minute 16 seconds 1 m 16 s A Morphett Vale drug seizure. ( Supplied: SAPOL )

"This seizure forms part of SAPOL's overarching methamphetamine response plan known as Operation ATLAS," Detective Superintendent Mark Trenwith said.

"We specifically target people manufacturing 'ice' to reduce supply and the associated serious harm to the community.

"This is a significant seizure and will potentially prevent kilograms of ice worth millions of dollars hitting the streets."

On Monday afternoon, 36-year-old Houshang Naroie from Seaview Downs and 40-year-old Shahram Kamali, who is believed to have recently arrived using an America passport, appeared in the Christies Beach Magistrates Court.

They did not apply for bail.

A police prosecutor sought to have the next court date in February 2020, due to extensive forensic and CCTV analysis.

However the defence lawyer objected and the magistrate gave police until next July.

Police are expecting to remain at the house for the rest of the day. ( ABC News: Tom Fedorowytsch )

Members of the Drug and Organised Crime Task Force have been dismantling the laboratory while the investigations continue.

"Clandestine drug laboratories pose significant risk to the community and contain corrosive, flammable and toxic chemicals that are often associated with fires and explosions," Detective Superintendent Trenwith said.

"This is a timely reminder to the community that people who seek to produce illicit drugs can face penalties up to $500,000 and or life imprisonment."

Two men were allegedly found at the house at Marston Drive on Sunday. ( ABC News: Tom Fedorowytsch )

The total street value of the seizure has not been confirmed and other chemicals and powders found at the property are yet to be analysed.

Anyone with information is urged to contact Crime Stoppers on 1800 333 000.