Here we already encounter a big problem. Nuclear proliferation is fairly straightforward to regulate, at least from a policy standpoint, because there are certain things that nobody needs unless they're trying to make a nuclear weapon. Synthetic biology offers no such list. Even if we were omniscient in regard to every single gene being ordered or sequenced worldwide, it would still be nearly impossible, in the absence of other information, to tell which people or organizations were pursuing peaceful research and which ones were up to no good. It would be the Wild West, with no black hats or handlebar mustaches to tip us off.