The space shuttle was about 37 meters from nose to tail; if those are the same size, then the FedEx ships are MASSIVE, and probably can't land. They'd need some sort of surface-to-air "interface vessel" with an aerodynamic lifting body to carry packages to and from planets with an atmosphere. Educated guess: All the cargo is carried in the red "container" under the fuselage, which can probably be detached at an orbital station and another one attached for the next destination. The orbital station would then handle the deliveries to the planet below, either by shuttle or by space elevator.



For smaller deliveries where the entire contents of the container do not need to be delivered to the planet below, the FedEx ship is clearly large enough for at least two shuttles in its hangar bay (and probably many more), which would also double as escape pods for the crew in an emergency. (Assuming they are of a similar size, each space shuttle had a cargo capacity of about 30 metric tons, and was designed for up to 8 crew members.) Oh, and is it just me, or does it look like the engines of the ships can be ejected two at a time (top pair and bottom pair), presumably for easier maintenance, and also so that it doesn't have to spend weeks in spacedock if it has an engine problem? Just drop off the pair of engines that had the problem, replace them with a freshly refurbished engine module, and head to the next destination. It would still take hours or even days to replace engine pods, but that's better than weeks. I dunno, it just sounds like something FedEx would do to keep turnaround time minimal.