NEW YORK -- San Diego Padres outfielder Jose Urena and two free-agent players have been suspended for violating baseball's minor league drug program.

The commissioner's office announced Thursday that Urena has been penalized along with outfielder Henry Charles and right-handed pitcher Adam Reifer.

Urena, 21, was handed an 80-game ban, effective immediately, after testing positive for a metabolite of Nandrolone, a performance-enhancing substance. He is on the roster at Class A Fort Wayne in the Midwest League. He batted .258 with seven homers, 45 RBIs and a .390 on-base percentage in 63 games for low-A Tri-City last season.

Charles also tested positive for a metabolite of Nandrolone and was given a 76-game suspension. Reifer received an 80-game punishment following a positive test for Ostarine, also a performance-enhancing substance, the commissioner's office said.

The suspensions for Charles and Reifer will take effect when they sign with another major league club.