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Earlier this month a study called the “Xylitol for Adult Caries Trial” was published in the American Dental Association Journal. Several of my dental friends contacted me with concerns and to find out what was going on. If you look closely at the study, the results are not surprising, but the shock was how quickly it reached the front page of the New York Times Health Section. I guess the conclusion of the study may seem shocking at first glance, because researchers found that xylitol did not significantly reduce cavities in adults who are at high risk for decay.

The researchers confirmed xylitol has been shown to be successful in reducing cavities for over 50 years in Europe, Asia and even in the US. These studies, however, have mainly focused on children and adolescents, so this new study took a look at adults in the US with a high rate of cavities. The hypothesis was that 5 grams of xylitol could stop new cavities in these selected clinic patients. After two and a half years, the conclusion was that the xylitol had only reduced decay by 10%, which was not significant.

The results did not surprise me, nor a well-respected lecturer, Dr Graeme Milicich from New Zealand. His comment was, “Water can put out a fire, but a cup of water is not going to deal with a house fire. The people selected in this study were high-risk patients, so throwing a cup of water at the problem, without any other intervention, is obviously not going to deal with it”. The patients in this study had serious decay problems and many had half their teeth missing. They experienced about 4 new cavities a year, yet it does not appear anyone addressed their lifestyle or other risk factors.

Xylitol’s main benefit is its alkalizing ability. You can do a pH test in your own mouth and show that 100 percent xylitol (like Zellies) quickly alkalizes your mouth to protect your teeth from acidity and sugars. This is why we recommend you eat Zellies after eating, after drinking and after snacking. If you eat xylitol and then sip diet soda or a 20 oz energy drink, the xylitol will have no chance to protect you. Most Americans snack frequently, particularly when it comes to sipping drinks.

To benefit from xylitol we must understand how teeth become damaged and how xylitol prevents the damage. If 5 pills a day could stop cavities – it assumes “cavities happen”, which is not the case. Acidity is the pivotal risk factor for cavities. Acidity is from plaque and also from foods and especially drinks that lower mouth pH. Older adults with cavities usually have acidic saliva due to hormonal change, pregnancy, stress, medications, or a depressed immune system. In the age-range of this study, many patients would have acidic or insufficient saliva to counter acidic attacks from eating or drinking. Only with the correct xylitol protocol and correct home care regimen could these patients have avoided cavities.

Anyone can test with pH paper and see how xylitol (mints or gum) can alkalize the mouth within minutes of an acidic challenge, to stop acidic damage and help protect teeth. This study used xylitol without any education, which is similar to giving a couple of “diet pills” to obese patients without any dietary advice, and then being shocked that they didn’t work!

Cavities are not a mystery or phenomenon – they are the progressive destruction of teeth to a point where the tooth caves in, allowing an infection to enter and destroy the tooth under the enamel. To prevent cavities, you must get rid of cavity-producing bacteria and protect teeth from acidity that weakens the outer enamel. The amount of daily prevention must outweigh the amount of damage to a tooth. I describe this as being like a bank balance, which is the outcome between how much you deposit each day vs. how much you withdraw. If the amount of damage to teeth exceeds the amount of help you give each day – you will end up with cavities. If you offer more protection than damage, cavities will stop. For adults with decay, it is important to control acidic damage from snacking habits. Zellies offers a simple and delicious tool, but it is the person who must make the effort, use Zellies to limit damage, and understand that even Zellies are not magic pills!

Another benefit of xylitol is that it can loosen plaque and improve daily tooth cleaning. Useful as this is, you still need well-formulated mouth rinses, good toothpaste and effective brushing habits. Additionally, xylitol must reach a minimum daily dosage, and Dr Milgrom’s studies at the University of Washington in 2002 indicated a dosage between 6.5 and 10 grams xylitol is required, and frequency is important. This is why you find so much information about how to use xylitol, how to clean your teeth, and which mouth rinses work with xylitol, etc on our websites.

This study was definitely at odds with the outcome that many of us, as dentists, have professionally witnessed with adult patients. We have prescribed effective protocols with xylitol that have allowed patients to escape a lifetime of cavities and dental problems. When used with proper education and application, xylitol can be an amazing oral health adjunct, especially for mouth acidity or dry mouth issues. The study admitted several problems, including “illogical” reversals, errors in one of the examination sites, and data that was “unusable”. There were some positive results– for example there was a 10-20% reduction in cavities in some groups, and the study showed ethnic variations, which may be interesting and could uncover cultural habits or unknown genetic factors.

The researchers in this study admitted decades of powerfully positive results using xylitol for preventing cavities in kids’ teeth. Hundreds of good and Evidence Based studies have shown it works to protect children and adolescents (see for yourself – go to Google Scholar and type in “xylitol” and “caries” and you will see 300+ studies showing xylitol’s incredible effect on preventing and reversing tooth decay). Isn’t it fascinating that the ADA and the media appear to have completely ignored those great stories, but picked a negative one and raced it to the NY Times in one day! I wish the media had been excited in the 1970s to tell mothers how xylitol prevents transmission of cavities to children (how many teeth would we have saved?) or the study last year that shows how wiping baby teeth during eruption can give long-term protection from cavities. I wonder why the ADA could not have commented on this most recent article – explaining what was lacking and using this as the perfect platform to discuss the dental dangers of sipping energy drinks, fruited waters, athletic drinks, juices and sodas.

Today we have an epidemic of tooth decay in 2 year olds, 52 million school hours are lost to dental disease annually, 80% of teenagers have fillings and 50% of 30 year olds have gum disease. NOW is the time to start encouraging the American public to improve their oral health and use xylitol to help reduce the staggering burden of disease in the US. Xylitol offers an easy and exciting method to help raise our standard of oral health – yet the unfortunate NY Times headlines will surely push us backwards on this path.

This is why we at Zellies will continue on our mission to educate followers about the powerful benefits of xylitol combined with good oral health education to stop, prevent and even reverse dental disease, cavities and gum problems.

Read the JADA Article here

Read the NY Times article here



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For more information on oral health and xylitol, please visit all of Dr. Ellie’s web-sites:



Zellies.com – learn more & order your Zellies Xylitol & the Complete Mouth Care System

Dr. Ellie.com – a great resource for learning more about oral health & Dr. Ellie

Dr. E Oral Health Coaching – articles, resources and videos to help you learn more

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Categories: Xylitol