Update, Feb. 17, 11 a.m. PST: This voting round is closed, we'll post the next round shortly.

Nobody ever said love was easy, and this Valentine's Day, TV fans participating in our E! Online TV's Top Couples Tournament will have to make tough choices between favorite couples, as Brittany & Santana from Glee take on Mark & Lexie from Grey's Anatomy, Chuck & Blair from Gossip Girl fight Eric & Sookie from True Blood, and Stefan & Elena from the The Vampire Diaries battle Derek & Meredith from Grey's Anatomy. Tough stuff, right?

Cast your vote in round two of our shipper-war bracket tournament to decide which television pairing is the best of the best! Which couple will prevail? Only you can decide: