Comedian Garry Shandling has died at a Los Angeles hospital on Thursday, March 24, police confirm to Us Weekly. He was 66.

In a media advisory, the Los Angeles Fire Department state that they responded to a medical emergency call made from the stand-up star’s home at approximately 10:40 a.m. He was taken to the hospital, where he was subsequently pronounced dead.

A source tells TMZ that the star appeared healthy and was speaking to friends the same day he passed away. The site also reports that the actor’s passing was sudden, as he was not known to be suffering from any life-threatening illnesses. As of now, a cause of death hasn’t been released.

Shandling’s career in show business spanned over 40 years as a celebrated sitcom writer, stand-up comedian, actor and producer.

The late multi-hyphenate is best known for his work on late-night television in the ‘80s and ‘90s and for starring in HBO’s The Larry Sanders Show, which ran for six season from 1992 to 1998. He appeared in his own Emmy-nominated sitcom on Showtime called It’s Garry Shandling’s Show, which debuted in 1986. In addition, the acclaimed Hollywood vet also served as a guest host for The Tonight Show Starring Johnny Carson and was in consideration to become Carson’s successor.

Shandling never married or had children. Calls to Shandling’s rep have not been returned.

Story is developing. Check back for updates.