We thank all members of the Koc University Computational Systems Biology group, especially C. Ulubas, A. Selim Aytuna and U. Ogmen (former PRISM development team). We thank former and current members of the Tel Aviv University Structural Bioinformatics group, particularly M. Shatsky (MultiProt) and E. Mashiach (FiberDock). This work has been supported by TUBITAK (Research Grant numbers: 109T343 and 109E207). This project has been funded in whole or in part with federal funds from the National Cancer Institute, US National Institutes of Health (contract number HHSN261200800001E). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the U.S. Government. This research was supported (in part) by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research. O.K. acknowledges support from the Turkish Academy of Sciences (TUBA).