Two savvy sisters are launching their successful Middle Eastern restaurant chain in the US, with the flagship location at 2 Astor Pl., Side Dish has learned.

Semsom, which means “sesame” in Arabic, is a fast-casual concept from Christine Assouad Sfeir and Carine Assouad.

The Astor Place eatery is a 1,256 square-foot space that will seat around 25 people and is slated to open early next year.

“This is their first venture in New York City. They were looking for a high-profile, very visible location,” said Craig Hantgan, of Esquire Properties, who is representing Semsom. Newmark Grubb Knight Frank’s Ross Kaplan and Kate Cohen represented the landlord in the Astor Place deal.

The sisters plan to open four more in New York in 2015 and three or four more in 2016, Hantgan said, adding they are looking at Times Square, the Garment Center and Madison Square Park locations.

Semsom, which started in Lebanon in 2008 and has grown to around 40 restaurants throughout the Middle East, is looking to capitalize on the healthy eating trend by opening 200 locations across the US by 2020.

Assouad Sfeir, who is also chief executive of Dunkin’ Donuts in Lebanon, was ranked No. 19 on the Forbes list of the 200 most powerful business women in the Arab world.

Semsom is more upscale than the food trucks that peddle falafel in Midtown. The sisters are developing a new menu for New York, but it will also include traditional offerings, from kabobs and shawarmas to falafels.