Anyone or anybody (oftentimes Homura Akemi) showing intense hatred or committing violence against QB himself or any representation of him.

For an entire comic of QB being beaten up, see pool #3797

The Pixiv tag is "QBを殴り隊 (QB wo Naguri Tai, "Team: 'We Wanna Beat Up QB'")"

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For a pool for the complete opposite reaction, see pool #4451 (Somebody Loves Kyubey)