Jeffrey Epstein’s apparent suicide while locked up at a federal jail is sparking questions for officials tasked with overseeing his custody as the disgraced financier awaited trial on sex-trafficking charges.

Reports of Epstein's death early Saturday left many officials and lawmakers voicing shock and demanding answers, with news that he killed himself coming just weeks after officials investigated a possible suicide attempt.

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Epstein was apparently taken off suicide watch before he died at the Manhattan jail, with federal authorities in New York and at the Justice Department in Washington expressing alarm over the death and saying the FBI would investigate.

“In addition to the FBI’s investigation, I have consulted with the Inspector General who is opening an investigation into the circumstances of Mr. Epstein’s death," Attorney General William Barr Bill BarrHillicon Valley: Subpoenas for Facebook, Google and Twitter on the cards | Wray rebuffs mail-in voting conspiracies | Reps. raise mass surveillance concerns Bipartisan representatives demand answers on expired surveillance programs YouTube to battle mail-in voting misinformation with info panel on videos MORE said in a statement.

Barr said he was "appalled" by Epstein's death and that his apparent suicide while in federal custody "raises serious questions that must be answered."

By opening an FBI investigation as well as watchdog review, officials are conducting simultaneous probes that could result in disciplinary action or carry more serious implications depending on whatever facts are found in the case.

Some lawmakers are already calling for people to be fired.

“Every single person in the Justice Department — from your Main Justice headquarters staff all the way to the night-shift jailer — knew that this man was a suicide risk, and that his dark secrets couldn’t be allowed to die with him," Sen. Ben Sasse Benjamin (Ben) Eric SasseMcEnany says Trump will accept result of 'free and fair election' McConnell pushes back on Trump: 'There will be an orderly transition' Trump says he'll sign order aimed at protecting premature babies in appeal to religious voters MORE (R-Neb.) wrote in a letter to Barr on Saturday.

Sasse, who chairs the Senate Judiciary oversight subcommittee, wrote that Epstein "should have been locked in a padded room under unbroken, 24/7, constant surveillance" given the previous possible suicide attempt.

"Obviously, heads must roll," he wrote.

Others expressed fury over the situation, noting Epstein's apparent suicide came two weeks after he was found unconscious in his cell with marks around his neck.

Many were left scrambling to find answers to a litany of questions Saturday, including when and why Epstein was removed from suicide watch and how secure his cell was.

“We need answers. Lots of them,” Rep. Alexandria Ocasio-Cortez Alexandria Ocasio-CortezOn The Money: Anxious Democrats push for vote on COVID-19 aid | Pelosi, Mnuchin ready to restart talks | Weekly jobless claims increase | Senate treads close to shutdown deadline McCarthy says there will be a peaceful transition if Biden wins Anxious Democrats amp up pressure for vote on COVID-19 aid MORE (D-N.Y.), a member of the House Oversight and Reform Committee, tweeted.

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"For them to pull him off suicide watch is shocking,” Cameron Lindsay, a former warden with experience working at three federal facilities, told NBC News. “For someone this high-profile, with these allegations and this many victims, who has had a suicide attempt in the last few weeks, you can take absolutely no chances. You leave him on suicide watch until he’s out of there.”

Preet Bharara Preetinder (Preet) Singh BhararaDemocratic attorneys criticize House Judiciary Democrats' questioning of Barr Clyburn echoes calls to rename Pettus bridge Support swells for renaming Edmund Pettus Bridge in Selma to honor John Lewis after his death MORE, the former top federal prosecutor in Manhattan, tweeted that he was "dumbfounded" by the incident.

Epstein, who awaited trial on charges of sexual abuse and trafficking involving girls in Florida and New York going back to the early 2000s, was being housed in a cell in the Special Housing Unit at the Metropolitan Correctional Center in lower Manhattan.

The U.S. Bureau of Prisons, which operates the jail, said in a statement that Epstein, 66, was found unresponsive in his cell around 6:30 a.m. on Saturday. Authorities said staff took immediate action to revive him and he was transferred to a local hospital for treatment where he was later pronounced dead.

The Bureau of Prisons declined to comment further to The Hill.

Conspiracy theories quickly erupted on social media Saturday, with many looking at the well-connected financier's apparent suicide through a political lens and at least one top Trump administration official promoting a conspiracy about his death.

President Trump Donald John TrumpSteele Dossier sub-source was subject of FBI counterintelligence probe Pelosi slams Trump executive order on pre-existing conditions: It 'isn't worth the paper it's signed on' Trump 'no longer angry' at Romney because of Supreme Court stance MORE's personal lawyer Rudy Giuliani Rudy GiulianiThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting CIA found Putin 'probably directing' campaign against Biden: report Democrats fear Russia interference could spoil bid to retake Senate MORE, meanwhile, questioned the “motives” behind Epstein's death.

“What does the word watch mean in the phrase suicide Watch? Who was watching?” the former New York City mayor tweeted.

What does the word watch mean in the phrase suicide

Watch? Who was watching? What does camera show? It is inconceivable Epstein could have hung himself if there was a suicide Watch? Follow the motives. — Rudy Giuliani (@RudyGiuliani) August 10, 2019

The severity of Epstein’s alleged crimes also fueled the flurry of inquiries from lawmakers, who said his suicide cut short his victims’ quest for justice.

The disgraced financier was in prison for allegedly sexually abusing and trafficking underage girls from 2002 to 2005 in an alleged scheme intended to appeal to powerful politicians in the U.S. and visiting from abroad.

Epstein’s death came just hours after a federal judge unsealed documents containing testimony from a girl Epstein is accused of trafficking in which she laid bare the inner workings of Epstein’s alleged operation.

“The death of Jeffrey Epstein does not end the need for justice for his victims or the right of the public to know why a prolific child molester got a slap on the wrist instead of a long prison sentence,” said Rep. Lois Frankel Lois Jane FrankelShakespeare Theatre Company goes virtual for 'Will on the Hill...or Won't They?' Florida Democrat introduces bill to recognize Puerto Rico statehood referendum Hillicon Valley: Democrats demand answers over Russian interference bulletin | Google Cloud wins defense contract for cancer research | Cyberattack disrupts virtual classes MORE (D-Fla.), whose district includes an oceanfront mansion where Epstein is said to have sexually abused dozens of minors.

Frankel went on to call for the House Oversight and Reform Committee to open a probe into a 2008 plea deal Epstein received that allowed him to serve only 13 months in prison and avoid federal sex-trafficking charges.

Rep. Jackie Speier Karen (Jackie) Lorraine Jacqueline SpeierOvernight Defense: House to vote on military justice bill spurred by Vanessa Guillén death | Biden courts veterans after Trump's military controversies House to vote on 'I Am Vanessa Guillén' bill Overnight Defense: Trump's battle with Pentagon poses risks in November | Lawmakers launch Fort Hood probe | Military members can't opt out of tax deferral MORE (D-Calif.), a member of the Oversight panel, echoed Frankel’s call, saying the committee “has a duty to ensure all those who played a role in this travesty of justice answer to those crimes.”

For their part, federal prosecutors in the case called Epstein's death “disturbing” and emphasized that they would continue to seek justice for his accusers even after the financier's death.

“To those brave young women who have already come forward and to the many others who have yet to do so, let me reiterate that we remain committed to standing for you, and our investigation of the conduct charged in the indictment – which included a conspiracy count – remains ongoing,” Geoffrey Berman, the U.S. attorney for the Southern District of New York, said in a statement.

STATEMENT OF MANHATTAN U.S. ATTORNEY ON THE DEATH OF DEFENDANT JEFFREY EPSTEINhttps://t.co/uCLv8aAPaZ pic.twitter.com/aQnRn3kjEH — US Attorney SDNY (@SDNYnews) August 10, 2019

While criminal proceedings against Epstein are likely to wind down, a lawyer representing a number of his accusers signaled that they would still pursue civil cases against his estate.

"On behalf of the victims I represent, we would have preferred he [Epstein] lived to face justice. Our civil cases can still proceed against his estate. Victims deserve to be made whole for the lifelong damage he caused. We’re just getting started," attorney Lisa Bloom tweeted.

At least one woman who said she was trafficked by Epstein when she was 15 years old expressed anger over the fact that Epstein would not have to stand for trial and face his accusers.

“I am angry Jeffrey Epstein won't have to face his survivors of his abuse in court,” Jennifer Araoz told CNN in a statement. “Epstein is gone, but justice must still be served. I hope the authorities will pursue and prosecute his accomplices and enablers, and ensure redress for his victims.”