BEIRUT, Lebanon — Thousands of protesters poured into the streets in the suburbs of Damascus, Syria, and in three of the country’s five largest cities on Friday, in a weekly show of defiance that came days before President Bashar al-Assad was expected to address Syrians for the first time in two months. Activists said at least 19 people were killed and dozens wounded.

Security forces fired on protesters in Homs, one of Syria’s most restive locales, and the police and protesters fought in Deir al-Zour, a large city in the east. But thousands were permitted to demonstrate in Kiswa, a town south of Damascus, where demonstrators carried banners that read, “Leave!” and “The people want the fall of the regime.”

Some opposition figures had speculated that the government might try to bring down a death toll that surged past 100 on one Friday in anticipation of Mr. Assad’s speech, which may come as early as Sunday. Syrian officials have portrayed the address as significant, though many in the opposition said their expectations were low.

As the day wore on, the toll approached 22, the number killed last Friday.

“We want freedom and dignity but not under President Bashar,” said a 30-year-old farmer in Kiswa who gave his name as Abdel-Rahman. “He keeps promising for three months on reforms but all we see is more killing and suffering.”