EXCLUSIVE: Jessica Chastain is set to star in and produce Painkiller Jane, from the self-titled graphic novel series written by Jimmy Palmiotti and Joe Quesada.

Chastain, no stranger to playing tough female roles, will play Jane Vasko, a New York City street cop who gets recruited by the FBI to infiltrate a major NYC drug and human trafficking ring. In a near death experience, Jane develops exceptional regenerative abilities that give her a unique indestructible advantage. With nothing to live for and no way to die, Painkiller Jane becomes an unstoppable force of nature seeking revenge to those who destroyed her life as she leaves a path of death and destruction in her wake.

Lotus Entertainment’s Lenny Beckerman will produce along with Solipsist Films’ Stephen L’Heureux (Sin City: A Dame To Kill For) and Chastain through her Freckle Films banner. Bill Johnson, Jim Seibel, Ara Keshishian and Palmiotti will exec produce.

The graphic novel series was published by Paperfilms.

Chastain can next be seen playing as a ruthless lobbyist in John Madden’s upcoming title Miss Sloane, which EuropaCorp is releasing domestically on November 25.

Lotus Entertainment’s recent credits include Hologram for the King with Tom Hanks, Z for Zachariah with Chris Pine and Margot Robbie and upcoming Halle Berry starrer Kidnap.

Graphic novelist Palmiotti has penned volumes of Deadpool, Jonah Hex, Punisher and is currently writing Harley Quinn for DC Comics. Monilith, based on his graphic novel, is set up at Lionsgate.

Chastain is repped by CAA, Mosaic and Hansen, Jacobson.

Palmiotti is repped by Lotus Management.