I'll give you another theory. How about Mr. Poopybutthole -- just as where there's flies, there's spiders -- wherever these parasites start blooming, Mr. Poopybutthole is a different species who is more benign, or more advanced. He subsists on lives like the way that hermit crabs steal other shells. Maybe Mr. Poopybutthole takes advantage of the holes put in your memory and kind of burrows into those pre-existing holes. So he shows up where those parasites are, and he's more of a fourth dimensional phantom species that isn't bound by space, and only appears in concentrations of temporal malfunction or misperception and breakdown. Mr. Poopybutthole is insinuating himself into the universe regardless of timeline. And the same powers that allow him to do that allow him to directly talk with the audience.