Alexandra Breckenridge (This Is Us, The Walking Dead), Martin Henderson (Grey’s Anatomy, Miracles From Heaven), Tim Matheson (The Affair, The Good Fight) and Annette O’Toole (Smallville, Marvel’s The Punisher) will lead the cast of Netflix’s contemporary romance drama series Virgin River based on the bestselling novels by Robyn Carr.

Virgin Rive, produced by Reel World Management and Roma Roth, centers around Melinda Monroe (Breckenridge), who answers an ad to work as a nurse practitioner in the remote California town of Virgin River. Desperate to move on from her painful past, she’s left everything behind in Los Angeles thinking it will be the perfect place to start fresh and leave her painful memories behind. But she soon discovers that small-town living isn’t quite as simple as she expected and that she must learn to heal herself before she can truly make Virgin River her home.

Henderson plays Jack Sheridan, a sharp-witted ex-Marine commander, who moved to Virgin River after his service was over in search of a peaceful life, far away from the horrors of war.

Matheson portrays Doc Mullins. Set in his ways and a bit of a curmudgeon, he’s not keen on working with anyone including Mel, who he views as a challenge to his authority.

O’Toole is Hope McCrea, Virgin River’s brash and blunt mayor – a little rough around the edges, but her saving grace is her love for the town and her mission to preserve it.

The cast also includes Jenny Cooper (Grey’s Anatomy) as Joey Barnes, Mel’s charming older sister, adviser, trusted confidante, and best friend; David Cubitt (Siren) as Calvin, the unquestioned leader of the largest of the many illegal pot fields that litter the landscape around Virgin River; Lexa Doig (Arrow) as Paige Lassiter, a local entrepreneur, and an illustrious baker with a warm smile who has secrets of her own; Daniel Gillies (The Originals) as Mark: Mel’s first love, strikingly handsome and accomplished, a surgeon in the Los Angeles ER where Mel worked; Lauren Hammersley (Orphan Black) as Charmaine Roberts, an attractive hair stylist from nearby Clear River, and competition for Jack’s attention; Benjamin Hollingsworth (Code Black) as Dan Brady, another former Marine under Jack’s command, Brady differs from Preacher in almost every way; Colin Lawrence (Riverdale) as John “Preacher” Middleton, Jack’s best friend, the two men served in the military together, and Ian Tracey (Bates Motel) as Jimmy, Calvin’s lieutenant and enforcer, anyone unfortunate enough to incur Calvin’s wrath is inevitably forced to deal with Jimmy.

Sue Tenney (Good Witch) serves as showrunner and executive producer. Roth and Chris Perry executive produce.

The Virgin River book series consists of 20 books which have sold more than 13 million copies.

Matheson is repped by Gersh, LINK Enterainment, and Jacobson, Russell, Saltz, Nassim & De La Torre. Breckenridge is repped by Atlas Artists, CAA and McKuin Frankel. O’Toole is repped by BRS/Gage Talent Agency and Harriett Sternberg Management.