Charlie’s Sandwich Shoppe, the venerated South End eatery on Columbus Avenue, will close at the end of June, the restaurant announced on Twitter.

“My brother and I want to walk out of here and not get carried out in an ambulance,’’ said Arthur Manjourides who runs the restaurant with his younger brother, Chris. “We love our customers and what we do. But we just felt it was time.’’

The Manjourides family has been associated with the sandwich shop - noted for its turkey hash - since the late 1920s when their father started running it. The current generation has spent the past several decades behind the counter. The next generation has found their calling not in the kitchen, but in high tech, higher education and film making, the family said.