Fox News host and Donald Trump supporter Sean Hannity has lashed out at fellow network star Megyn Kelly after she accused him of being a 'safe space' for the Republican nominee to speak.

Kelly made the remark that seemed to set Hannity off during an interview with political pundit Stuart Stevens about how Hillary Clinton and Trump are approaching Sunday's second debate.

'They are both in their own version of a presidential protection program,' Kelly said on The Kelly File.

Fox News host and Donald Trump supporter Sean Hannity has lashed out at fellow network star Megyn Kelly (pictured) after she accused him of being a 'safe space' for the Republican nominee

'They've designed her situation so she is not in a place she feels uncomfortable or where anything unexpected could come at her.

'And Donald Trump, with all due respect to my friend at 10:00, will go on Hannity and pretty much only Hannity and will not venture out to the unsafe spaces these days, which doesn’t exactly expand the tent for either one of them.

'There, that's my two cents.'

Hannity, who has reportedly been an informal adviser for the Trump campaign since earlier this year, tweeted furiously at Kelly after her comments aired.

'Donald Trump, with all due respect to my friend at 10:00, will go on Hannity and pretty much only Hannity and will not venture out to the unsafe spaces these days,' Kelly said on Wednesday night

Sean Hannity (right, with Donald Trump) took offense at Kelly's comments he would be a soft interview for the Republican nominee

'@megynkelly u (sic) should be mad at @HillaryClinton Clearly you support her. And @realDonaldTrump did talk to u (sic),' Hannity wrote.

Kelly had not responded to the tweet on Wednesday night.

The clash comes a day after Trump himself attacked Kelly on Twitter ahead of Tuesday's vice presidential debate.

'@megynkelly u (sic) should be mad at @HillaryClinton Clearly you support her. And @realDonaldTrump did talk to u (sic),' Hannity tweeted on Wednesday

Hannity (right) has reportedly been advising Donald Trump and his campaign in recent months

Before the debate kicked off, Kelly joked on-air about Trump saying he was going to live-tweet the debate.

Kelly said Trump would be: 'surrounded by his team! Kellyanne's got the thumbs. Only when they're released will he [tweet].'

The reality television host shot back: 'I am in Nevada. Sorry to inform you Kellyanne is in the audience. Better luck next time.'