According to the NBA’s latest injury report, released at 8:30 p.m. EST on Nov. 19, Cavs center Tristan Thompson is out for rest when the team plays the Heat in Miami on Wednesday. This will be the first game Thompson will miss this season.

The report also lists Kevin Love as probable with a low back contusion and Larry Nance Jr. as questionable with a left thumb sprain. As expected, John Henson and Dylan Windler are both out with a right hamstring strain and a stress reaction in his left leg, respectively.

Thompson getting a night off makes sense. He’s averaging a career-high minutes per game and is someone the Cavs want to keep healthy. It’ll be harder for the Cavs to navigate, though, if Love and Nance remain out. Ante Zizic, although he’s still working his way back from injury, could be in line for a minutes bump. Two-way players Dean Wade and Tyler Cook, both of whom are with the team, could also see minutes.

For the Heat, Dion Waiters is out after being suspended by the team, KZ Okpala is out with an Achilles strain and Justise Winslow is out with a concussion. Wednesday’s game tips off at 7:30 p.m. in Miami.