LONDON — Deutsche Bank said on Thursday that it planned to cut as many as 35,000 jobs through internal cuts and the sale of businesses over the next two years as part of an overhaul by John Cryan, the bank’s new co-chief executive, to simplify the lender and improve its returns.

As part of its revamping, the German bank, which has a big presence on Wall Street, plans to shut its operations in 10 countries, cut the numbers of its investment banking customers in half and modernize its technology. It also plans to close 200 branches in Germany.

Also Thursday, Deutsche Bank reported that it had lost 6.02 billion euros, or about $6.6 billion, in the third quarter.

The loss, which the bank warned investors about this month, was primarily driven by a write-down after a decline in the paper value of two of its businesses, as well as charges for regulatory investigations and litigation.