BOSTON (Reuters) - Microsoft Corp issued its biggest-ever security fix on Tuesday, including repairs to its ubiquitous Windows operating system and Internet browser for flaws that could let hackers take control of a PC.

Customers shop at Microsoft's first retail store during the grand opening in Scottsdale, Arizona October 22, 2009. REUTERS/Joshua Lott

The new patches aim to fix a number of vulnerabilities including the notorious Stuxnet virus that attacked an Iranian nuclear power plant and other industrial control systems around the world.

Microsoft said four of the new patches -- software updates that write over glitches -- were of the highest priority and should be deployed immediately to protect users from potential criminal attacks on the Windows operating systems.

Microsoft said it also repaired other less serious security weaknesses in Windows, along with security problems in its widely used Office software for PCs and Microsoft Server software for business computers.

Microsoft released 16 security patches to address 49 problems in its products, many of which were discovered by outside researchers who seek out such vulnerabilities to win cash bounties as well as notoriety for their technical prowess.

“This is a huge jump,” said Amol Sarwate, a research manager with computer security provider Qualys Inc. “I think the reason for it is that more and more people are out there looking for vulnerabilities.”

The geeks who report such vulnerabilities to software makers are known as “white hat” hackers. Sarwate warned that there are also plenty of “black hats,” or criminal hackers who look for vulnerabilities in software that they can exploit to launch attacks on computer systems.

Indeed, the world’s biggest software maker said that the patches released on Tuesday include software to fix a vulnerability exploited by the Stuxnet virus -- a malicious program that attacks PCs used to run power plants and other infrastructure running Siemens industrial control systems.

The virus, which infected computers at Iran’s Bushehr nuclear power plant, was discovered over the summer. Security research Symantec said that it detected the highest concentration of the virus on computer systems in Iran, though it was also spotted in Indonesia, India, the United States, Australia, Britain, Malaysia and Pakistan.

So far Microsoft has patched three of the four vulnerabilities exploited by Stuxnet’s unknown creators.

The total of 49 vulnerabilities exceeds the previous record of 34, which was set in October 2009 and matched in June and August of this year.

The constant patching of PCs is a time-consuming process for corporate users, who need to test the fixes before they deploy them to make sure they do not cause machines to crash because of compatibility problems with existing software.