When the Baltimore Ravens and Cincinnati Bengals meet in Week 1, Cincinnati could be without a key player on offense. Bengals rookie wide receiver John Ross could miss the game after a knee sprain took him out of Cincinnati’s preseason finale against the Indianapolis Colts.

#Bengals WR John Ross suffered a knee sprain that knocked him out of the game last night, source said. But opener could be in doubt. — Ian Rapoport (@RapSheet) September 1, 2017

Though a knee sprain can very well mean a lot of things, Dr. Selene Parekh provided a little context on just how long Ross could be out. It’s far from definite, but it certainly helps cast some doubt on Ross’ availability in the first game.

Depending on severity, he could be out two to four weeks. Sometimes steroid injection required — Dr. Selene Parekh (@seleneparekhmd) September 1, 2017

If what Parekh said is true, Ross and the Bengals could have more issues than Week 1. After squaring off against Baltimore to open the season, Cincinnati faces the Houston Texans, Green Bay Packers and the Cleveland Browns in weeks 2-4. Not having their first-round selection in the lineup for several weeks could be a big blow for their offense in the season.

Baltimore has done a lot to improve their secondary in the offseason, adding Tony Jefferson and Brandon Carr in free agency and selecting Marlon Humphrey in the first round of the 2017 NFL draft. Not to mention undrafted rookie Jaylen Hill has been the best cornerback for Baltimore during the preseason. This could be bad news for Cincinnati’s passing game.

Cincinnati will already be without linebacker Vontaze Burfict, who recently had his five-game suspension brought down to three weeks, while cornerback Adam Jones is suspended for the first week. If Ross can’t suit up after all, it would be three major names missing an important division game.