The study was supported by the DFG (SFB914 TP B8, SFB1123 TP A6, B5, Z1, SO876/6-1, SO876/11-1, AN372/14-3, AN372/24-1, INST409/97-1FUGG and INST409/150-1FUGG), the EKFS (2016_A118, 2017_A13), the NWO (VIDI project 91712303), the Leducq foundation, and the Vetenskapradet. Funding was also provided by grants SAF2015-65607-R to A.H., BES-2013–065550 to J.M.A., and Severo Ochoa Center of Excellence (award SEV-2015-0505) to CNIC, all from the Ministerio de Ciencia, Innovacion y Universidades. We thank O. Schengel for mouse genotyping and V. Lavilla for generating video animations. This work used the platforms of the Grenoble Instruct-ERIC Center (ISBG: UMS 3518 CNRS-CEA-UGA-EMBL) with support from FRISBI (ANR-10 INSB-05-02) and GRAL (ANR-10-LABX-49-01). E.Y.L. acknowledges support from the Systems and Integrative Biology Training Program (T32GM008185), the Medical Scientist Training Program (T32GM008042), and the Dermatology Scientist Training Program (T32AR071307) at UCLA. E.Y.L. and G.C.L.W. acknowledge an Early Career Research Grant and a Discovery Grant, respectively, from the National Psoriasis Foundation. G.C.L.W. also acknowledges support from NIH R56AI125429-01A1.

Reviewer information

Nature thanks Peter Libby and the other anonymous reviewer(s) for their contribution to the peer review of this work.