3.) Dolichol Inhibition

Dolichols are vital to the process of glycoprotein formation in the endoplasmic reticula of cells. In this capacity it is critical to the formation of the glycoproteins involved in neuropeptides, cell identification, cell messaging and immunodefense. Reduced bioavailability of dolichols can affect every cellular process in the body.



Neuropeptide Dysfunction Potential Side Effects:

Aggressiveness

Hostility

Irritability

Road Rage

Homicidal Behavior

Depression

Suicide



Altered Glycoprotein Synthesis Potential Side Effects:

Impairment of DNA error correction

Dysfunction of almost any cellular process

Altered cell identification

Altered cell messaging

Altered immunodefense

4.) Tau Protein Synthesis

When normal phosphorylation is interfered with by mevalonate blockade, our cells increase the production of Tau protein. Tau is the protein substance of the neurofibrilatory tangles common to Alzheimer's and other neurodegenerative diseases.

Neuro-Degenerative Diseases Include:

Parkinson's Disease

Alzheimer's Disease

Amyotrophic Lateral Sclerosis ( ALS )

Primary Lateral Sclerosis ( PLS )

Multiple Sclerosis ( MS )

Multiple System Atrophy ( MSA )

Frontal Lobe Dementia

5.) Selenoprotein

Only recently discovered were selenoproteins and the effect of statin blockade of the mevalonate pathway on their role in human physiology. Deficiency of selenoproteins has been proven to result in various types of myopathies formerly seen only in areas known to be deficient in this trace element. Additionally cognitive dysfunction is known to be associated with selenium lack.

6.) Nuclear Factor - kappa B (NF-kB)

The benefit of statin drugs in cardiovascular disease control is in their ability to inhibit this vital transcriptase. The entire anti-inflammatory and immunomodulatory effect of statins is mediated by statin inhibition of nuclear factor-kappa B. Improvement in atherosclerosis results from the inhibition of the key inflammatory elements: smooth muscle migration. lymphocyte adhesion, macrophage attraction and platelet activation associated with inhibition of NF-kB. The immunodefense system is also keyed to NF-kB, explaining the changing patterns of certain infections and cancers. The rise in cancers of all kinds secondary to statin use is of major concern.