EXCLUSIVE

2:28 PM PT -- Wayne has been transported to a hospital by ambulance.

2:00 PM PT -- We're told Lil Wayne just suffered ANOTHER seizure after refusing medical attention and going back onto his private jet. We're told his plane was in the air for minutes when the 2nd seizure occurred ... and was forced to land in Omaha once again.

Our sources say Wayne once again lost consciousness ... and the paramedics are treating him on the aircraft.

Lil Wayne suffered a seizure during a cross-country flight, forcing his private jet to make an emergency landing in Nebraska ... TMZ has learned.

Wayne was flying from Milwaukee to California when the seizure struck -- and we're told he'd blacked out when the pilot put the jet down Monday afternoon in Omaha.

Paramedics are at the airstrip right now, and Wayne is alert again. As of 1:30 PM PT ... we're told he's refusing medical treatment.

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TMZ broke the story, the same thing happened to Weezy in 2012 ... when his private jet made emergency landings two days in a row. He also suffered seizures in 2013 -- one of which was nearly fatal.

Wayne has said he's epileptic and has suffered seizures since childhood. Years ago he said he quit drinking lean because of the seizures, but last night in Milwaukee he was double-cupping in plain sight.