Jerry Seinfeld is master of his comedy domain.

“Seinfeld” was voted the nation’s funniest sitcom of all time, edging out the 1950s black-and-white classic “The Honeymooners,” according to survey results published yesterday.

The long-running NBC hit series “Seinfeld” — self-described as being “about nothing” — picked up 22 percent of respondents’ votes in the poll commissioned by “60 Minutes” and Vanity Fair magazine.

Close behind was Jackie Gleason’s “The Honeymooners,” with 20 percent, “Friends,” at 16 percent, and “Cheers,” at 14 percent.

Fox’s critically acclaimed “Arrested Development” garnered 7 percent, and “The Mary Tyler Moore Show” scored 6 percent.

The most popular current show — “30 Rock,” featuring “Saturday Night Live” alum Tina Fey — picked up 5 percent.

“Seinfeld,” the comedy brainchild of funny men Jerry Seinfeld and Larry David, produced 180 episodes between 1989 and 1998.

“Seinfeld” seems to run nonstop — in syndication on TBS, and locally on Channel 11. The show’s classic episodes are still water-cooler talk now, more than a decade later.

“Seinfeld’s” famed Nov. 18, 1992, “The Contest” is one of comedy’s most revered episodes because it was all about masturbation — but the word was never used. Instead the cheeky euphemism “master of my domain” served as the episode’s punch line.

The “60 Minutes”/VF poll also found that 60 percent of Americans — including most women — think men are the funnier gender, compared to just 22 percent think females are funnier.

Fifteen percent of respondents said there’s no difference between the genders in comedy talent.