The first slate of Sunday games for Week 5 of the NFL season kicks off at 1 p.m. Make sure you check out who is active and who isn’t before you set your lineups:

Noteworthy Inactives

Mitchell Trubisky, QB, Chicago Bears (shoulder) – Trubisky took a hit on the first drive of the game in Week 4. It was reported Monday he had dislocated his non-throwing shoulder and the injury is not considered serious. He will miss Week 5 against the Broncos, however, and backup quarterback Chase Daniels will get the start.

Sam Darnold, QB, New York Jets (mononucleosis) – Despite positive midweek reports, Sam Darnold will miss this game as his spleen remains enlarged and is not cleared for contact. Backup quarterback Luke Falk will get the start against the Eagles, which is a downgrade for the entire Jets offense.

Case Keenum, QB, Washington Redskins (foot) – Case Keenum was seen in a walking boot on Wednesday. He was pulled from the game on Sunday and replaced by Dwayne Haskins. After much confusion throughout the week, backup quarterback Colt McCoy will get the start against the Patriots in Week 5, per head coach Jay Gruden.

Saquon Barkley, RB, New York Giants (ankle) – Barkley suffered a high ankle sprain in Week 3 and has been out since. Videos of Saquon working out circulated around social media this week, suggesting an earlier return. It was announced on Friday, however, that he would miss Week 5 against the Vikings. If Wayne Gallman (neck) is healthy, he should get the lion’s share of the touches.

Rex Burkhead, RB, New England Patriots (foot) – It was reported by Adam Schefter on Saturday that Burkhead would miss Week 5 against the Redskins after being limited in practice all week. Sony Michel and James White should see more work with Burkhead out, and rookie Damien Harris is expected to dress.

Jamaal Williams, RB, Green Bay Packers (concussion) – Williams suffered a nasty concussion after a helmet-to-helmet hit during Week 4 against the Eagles. He will sit out this week, meaning even more work for workhorse back Aaron Jones.

Justin Jackson, RB, Los Angeles Chargers (calf) – Jackson was a non-participant through three practices this week and will miss Week 5 against the Broncos. Austin Ekeler and newly returned Melvin Gordon will take on most of the workload with Troymaine Pope seeing some touches without Jackson on the field.

Davante Adams, WR, Green Bay Packers (toe) – Adams is dealing with turf toe after injuring himself during Week 4 against the Eagles and was ruled out on Friday. Marquez Valdes-Scantling and Geronimo Allison should see increased targets against the Cowboys.

Devin Singletary, RB, Buffalo Bills (hamstring) – Singletary has been out since Week 2 after suffering a hamstring injury. He was a limited participant in practice this week and is inactive for this game. Frank Gore will continue to shoulder the workload, with T.J. Yeldon more involved in the passing game.

Tyreek Hill, WR, Kansas City Chiefs (clavicle) – Hill had surgery on his clavicle before the season started and will sit out again in Week 5 against the Colts. Sammy Watkins is questionable for this game, meaning that rookies Mecole Hardman and Demarcus Robinson should continue to see more targets.

DeSean Jackson, WR, Philadelphia Eagles (abdomen) – DeSean Jackson was ruled out on Friday for Week 5 against the Jets. He has been dealing with an abdomen injury since Week 2 against the Falcons.

Christian Kirk, WR, Arizona Cardinals (ankle) – Kirk sustained what appeared to be a serious ankle injury in Week 4 against the Seahawks. It seems that he avoided a serious injury and head coach Kliff Kingsbury said that “he’s come quite a ways.” However, he will sit out this week’s matchup against the Bengals.

Parris Campbell, WR, Indianapolis Colts (abdomen) – Campbell underwent a procedure for an injury to his abdomen sustained during Week 4 against the Raiders. He did not practice this week and was ruled out for Week 5 against the Chiefs.

Kenny Stills, WR, Houston Texans (hamstring, ankle) – Stills injured his hamstring and ankle in Week 4 against the Panthers and exited the game. Sources told Ian Rapoport on Sunday that it is unlikely he plays. Slot receiver Keke Coutee should see an increase in targets.

Tyrell Williams, WR, Oakland Raiders (foot) – Tyrell Williams has not been practicing due to a foot injury. He will not play against the Bears in Week 5, per Field Yates of ESPN.

Hunter Henry, TE, Los Angeles Chargers (knee) – Henry showed improvement throughout the week in practice, but was ruled out for Week 5 against the Broncos. He has missed the past three games after suffering a tibia plateau fracture to his knee during Week 1 against the Colts. With Henry out and Green questionable, Lance Kendricks should see more targets.

Tyler Kroft, TE, Buffalo Bills (ankle) – Kroft was a non-participant in practice all week due to an unrelated ankle injury following surgery for a broken foot. Rookie Dawson Knox has been playing well in his absence and will get the start against Tennessee.

Jordan Reed, TE, Washington Redskins (concussion) – The oft-injured Reed has missed all season dealing with a concussion. He’s had multiple concussions and will sit again this week.

Vernon Davis, TE, Washington Redskins (concussion) – Davis is also in the concussion protocol after taking a hit on Sunday against the Giants and will not play against the Patriots in Week 5. Jeremy Sprinkle and Jerome Cunningham will be the available tight ends with both Reed and Davis out.

Noteworthy Actives

Josh Allen, QB, Buffalo Bills (concussion) – Allen suffered a concussion on a helmet-to-helmet hit during Week 4 against the Patriots. He was a full participant in Friday’s practice and it was announced by the Bills on Saturday that Allen was cleared through the concussion protocol and will start against the Titans.

James Conner, RB, Pittsburgh Steelers (ankle) – Conner has been dealing with an ankle injury since 2018 and missed practice Wednesday and Thursday. He expects to start in Week 5, but could be limited throughout the game, which would mean Jaylen Samuels would see more snaps.

Wayne Gallman, RB, New York Giants (neck) – Gallman was a limited participant in practice Wednesday and Thursday dealing with a neck injury, but is not listed on the Giants injury report going into Week 5 against the Vikings. He should continue to see a huge workload with Saquon Barkley already ruled out.

LeSean McCoy, RB, Kansas City Chiefs (ankle) – McCoy was a full participant in Thursday’s practice after being limited earlier in the week. He is not on the injury report going into Week 5 against the Colts and should be good to play Sunday night.

Damien Williams, RB, Kansas City Chiefs (hamstring) – Williams was also a full participant in practice this week after missing two games. This means you can probably bench Darrel Williams, especially if McCoy plays.

JuJu Smith-Schuster, WR, Pittsburgh Steelers (toe) – Smith-Schuster was listed as a full participant during Friday’s practice but is questionable to start in Week 5 against the Ravens while dealing with a toe injury since Week 1. He was officially declared active. as reported by Adam Schefter, but keep in mind that the Ravens defense is decent and Smith-Schuster’s ceiling is capped with check- down quarterback Mason Rudolph under center.

Julian Edelman, WR, New England Patriots (chest) – Edelman will play today against the Redskins, per Adam Schefter of ESPN. He was limited in practice all week after suffering a pectoral injury in Week 4 against the Bills.

T.Y. Hilton, WR, Indianapolis Colts (quad) – Hilton did not practice on Wednesday after missing Week 4 due to a quad injury. Sources told Adam Schefter of ESPN on Sunday that he is expected to play.

Sammy Watkins, WR, Kansas City Chiefs (hamstring, shoulder) – Watkins was a limited participant during Friday’s practice. He is questionable to start in Week 5 against the Colts, but sources told Adam Schefter that he should play.

Terry McLaurin, WR, Washington Redskins (hamstring) – McLaurin suffered a hamstring injury during practice two weeks ago and missed Week 4. He is active against the Patriots, but avoid if possible as he will likely draw coverage from cornerback Stephon Gilmore.

Jarvis Landry, WR, Cleveland Browns (concussion) – Landry was cleared through the concussion protocol and was a full participant in practice on Friday. He will start against the 49ers in Week 5 and continue to be an “integral part of the offense,” according to head coach Freddie Kitchens.

Michael Gallup, WR, Dallas Cowboys (knee) – After missing two games due to a knee injury, Gallup is expected to start in Week 5 against the Packers per Adam Schefter.

Mike Williams, WR, Los Angeles Chargers (back) – Williams practiced in full on Friday and told Eric Williams of ESPN that he will play on Sunday against the Broncos.

Demaryius Thomas, WR, New York Jets (hamstring) – Thomas looked good in practice this week per head coach Adam Gase and is active for Week 5 against the Eagles.

Vance McDonald, TE, Pittsburgh Steelers (shoulder) – McDonald will start against the Ravens after missing two weeks with a shoulder injury per Ian Rapoport. He was a full participant in Friday’s practice

Still Questionable

Marlon Mack, RB, Indianapolis Colts (ankle) – Mack exited the game last week against the Raiders with an ankle injury and was a non-participant through two practices this week. He was a full participant on Friday but it will be a game time decision if he starts against the Chiefs, per Ian Rapoport. Jordan Wilkins would benefit the most if he sits, with Nyhiem Hines more of a pass catcher. Proceed with caution given that the Colts play on Sunday night.

Tevin Coleman, RB, San Francisco 49ers (ankle) – Coleman has been out since Week 1 with an ankle injury he suffered against the Buccaneers. He practiced on Thursday and Friday, and head coach Kyle Shanahan said he’s “good to go” but is listed as questionable for Week 5. With this game happening on Monday night, you should have a backup plan if Coleman ultimately sits.

Rashard Higgins, WR, Cleveland Browns (knee) – Higgins practiced in full on Saturday, but is questionable for Week 5 against the 49ers. Even if he plays, he will be downgraded significantly now that Antonio Callaway has returned from suspension.

Travis Benjamin, WR, Los Angeles Chargers (hip) – Benjamin was a full participant in practice on Friday, but is still questionable for Week 5 against the Broncos.

Virgil Green, TE, Los Angeles Chargers (groin) – Green missed last week with a groin injury and is questionable again after being limited in practice this week.