Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence

Version 1 : Received: 9 April 2020 / Approved: 13 April 2020 / Online: 13 April 2020 (02:23:33 CEST)



How to cite: Sardu, C.; Gambardella, J.; Morelli, M.B.; Wang, X.; Marfella, R.; Santulli, G. Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence. Preprints 2020, 2020040204 (doi: 10.20944/preprints202004.0204.v1). Sardu, C.; Gambardella, J.; Morelli, M.B.; Wang, X.; Marfella, R.; Santulli, G. Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence. Preprints 2020, 2020040204 (doi: 10.20944/preprints202004.0204.v1). Copy

Cite as: Sardu, C.; Gambardella, J.; Morelli, M.B.; Wang, X.; Marfella, R.; Santulli, G. Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence. Preprints 2020, 2020040204 (doi: 10.20944/preprints202004.0204.v1). Sardu, C.; Gambardella, J.; Morelli, M.B.; Wang, X.; Marfella, R.; Santulli, G. Is COVID-19 an Endothelial Disease? Clinical and Basic Evidence. Preprints 2020, 2020040204 (doi: 10.20944/preprints202004.0204.v1). Copy CANCEL COPY CITATION DETAILS

Abstract

The symptoms most commonly reported by patients affected by coronavirus disease 2019 (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g. high blood pressure, thrombosis, pulmonary embolism) seem to suggest that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ of COVID-19.

Subject Areas

Covid-19; coronavirus; cardiovascular disease; thrombosis; hypertension; endothelial dysfunction

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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