An e-bike rider collided with a 77-year-old in Central Park — and in a bizarre twist, the cyclist died while the elderly man suffered only minor injuries, police said on Thursday.

Harlem dad Charles Cheeseboro, 43, was riding the battery-powered, hand-throttled, pedal-assist e-bike north on East Drive when he ran a red light and slammed into the victim near 74th Street around 3:30 p.m. Monday, cops and sources said.

Cheeseboro, who was not wearing a helmet at the time, went flying off the bike upon impact, authorities said.

The bicyclist was rushed to NewYork-Presbyterian Hospital with head trauma, and he died on Wednesday, police said.

“He had a hard fall,” Cheeseboro’s devastated sister, Tara Cheeseboro, told The Post on Thursday. “He flew off his bike and hit his head real hard.”

Tara said she raced to the hospital when she found out about her brother’s wreck.

“When I first saw him, he looked like he was sleeping. He was unconscious. I just cried,” she said. “I was praying with him. I told him, ‘You are a fighter. I hope you pull through.’ ”

The collision also sent the Upper West Side pedestrian, who had the right of way, to the same hospital with minor injuries.

It was not immediately clear how fast Charles was going at the time of the wreck. Bicycles are not allowed to have throttles under city rules.

“It was a tragedy what happened,” Tara said. “I hope [the pedestrian] has a speedy recovery.”

Tara said her brother, a father of four nicknamed “Gutter” and “Junior,” was a music producer and video editor who worked on videos for local rappers.

“He was a big gentle giant. He was a loving and caring person. He was loved by many,” she said.

Tara said Charles used the bike as his primary mode of transportation — though she didn’t know where he was headed on Monday.

She called her brother “very careful” and “a good rider,” but noted that he was hit twice by cars in June while riding his bike.

The fatal incident marked the 20th cyclist death this year, though most of the victims were killed by cars.

“There has been a lot of fatal accidents with these cyclists,” Tara said. “They have got to do something about it . . . we don’t want people to stop riding, but do something so they are safe.”

Additional reporting by Larry Celona