An elderly man has died two days after being hit by a car in Caulfield South, becoming the second Melbourne pedestrian to lose his life within three days.

The 82-year-old was taken to hospital in a critical condition on Saturday after he was hit while attempting to cross Hawthorn Road. He died in hospital on Monday.

The driver, a 29-year-old Glenhuntly woman, stopped at the scene to assist police, with investigations continuing.

It comes after a 25-year-old man died on Friday night in Wyndham Vale.

In that incident, it is believed the pedestrian was hit by a silver Hyundai hatchback on Armstrong Road, near the intersection of Greens Road, about 10.40pm. He died at the scene.

The driver, a 36-year-old Werribee woman, was released pending further enquiries. Detectives from the Major Collision Investigation Unit want to speak with anyone who may have seen the pedestrian in the area around the time of the incident or in the hours leading up to it.

The road toll now stands at 189, compared to 131 at the same time last year.

Any witnesses or anyone with dashcam footage is urged to contact Crime Stoppers on 1800 333 000 or submit a confidential report at www.crimestoppers.com.au.