What do comedians and scientists have in common? Often, it's a love of all things geeky, and nowhere is that more obvious than at TAM London, the UK's biggest conference celebrating science and critical thinking. Now in its second year, TAM (short for The Amazing Meeting) has been described by Jonathan Ross as "the best event ever!!!" and arrives this weekend with a line-up of speakers including Richard Dawkins, comic book legend Alan Moore, Graham Linehan and Stephen Fry.

Guardian Science blogger Martin Robbins is covering the event here with a live-blogging marathon over the weekend, featuring commentary, audio clips and photos from the conference and fringe events.

TAM London is a fundraiser for the James Randi Educational Foundation, home of the Million Dollar Paranormal Challenge, which promotes critical thinking and scientific literacy.

Organiser Tracy King said: "The focus is on entertainment and education. People come to TAM because they want to learn and hear from leading speakers on subjects which interest them, but they want to have a good time doing it. Our mix of academics, comedians and writers ensures an incredible event where the public can meet like-minded people without feeling like being into science or geek stuff makes them a minority.

"With science funding under threat, it's more important than ever for TAM London to reach the public with its message – that science, technology and rational thinking are essential to the healthy future of the UK."

The full TAM London 2010 line-up includes:

Tim Minchin, Richard Dawkins, Stephen Fry, James Randi, Graham Linehan, Richard Wiseman, Marcus Chown, Sue Blackmore, PZ Myers, Alan Moore, Melinda Gebbie, Andy Nyman, Robin Ince, Adam Rutherford, Simon Singh and Cory Doctorow. Details can be found at www.tamlondon.org