Objectives of Study：

HIV-induced AIDS is a major medical problem that threatens all human beings in today's world, affecting the safety and health of all human beings. To date, there is no effective drug or clinical technique to completely cure AIDS. Fortunately, governments and scientists around the world have invested a lot of energy in HIV prevention and post-infection interventions. However, we are far from achieving the WHO's 2020 HIV prevention goals and have a long way to go to eliminate HIV. The only HIV-infected person who has been recognized as completely cured in the world is the Berlin patient”. At that time, the patient developed leukemia and was diagnosed as HIV-positive before the bone marrow stem cell transplant. The German doctor used a bone marrow matching to creatively treats leukemia in this patient with a rare CCR5 genetic mutation existing in Western European population resistant to HIV-1. To date, "Berlin patient" has not detected with HIV in the body, creating a new medical model for HIV elimination. The current clinical trial is based on preclinical research of cell lines, animal models and human waste embryos. It recruits HIV-positive patients with infertility and informs the volunteers of the risks and benefits through sufficient informed consenting. The informed consent form is signed through one-on-one discussion. The study design was submitted to the ethics committee of the hospital for discussion and approval. Through the CCR5 gene editing of the human embryo in a comprehensive test system, we set to obtain healthy children to avoid HIV providing new insights for the future elimination of major genetic diseases in early human embryos.