Isabel Celis as she appeared in 2012, when at age 6, she vanished.

Missing Tucson girl Isabel Celis was confirmed dead today, police reported.

Isabel was 6 years old when she disappeared in 2012. Tucson Police Chief Chris Magnus told reporters Friday afternoon that her body was found in “rural Pima County” and was identified by a DNA match.

Magnus did not specify the location or many details at a 3:30 p.m. press conference.

Isabel Celis Handout Poster

Results from a private lab in Virginia confirmed their worst suspicions when they uncovered an unknown body of a child earlier this month.

"We see this as absolutely a tragedy," Magnus said. "We were all hoping to find her alive."

Isabel vanished on April 20, 2012, from her east side home. The next morning, her father, Sergio Celis, reported her missing when he went to her bedroom to wake her up for a baseball game, but she was gone.

Investigators spent weeks conducting door-to-door and widespread searches, 18 months after she disappeared. Police interviewed neighbors, canvassed parks, searched a landfill, and reviewed surveillance video from nearby businesses.

One neighbor reported hearing barking dogs outside Isabel's bedroom window at 6:30 a.m. on the day she vanished. There were reports of estranged family members, including one who refused to help detectives.

Isabel's case made national headlines.

An simulation of how Isabel Celis would look today, if she had lived. Courtesy of National Center for Missing and Exploited Children

Detectives checked out 2,200 investigative leads, Magnus said.

According to the National Center for Missing and Exploited Children, there are still 135 missing children in Arizona.

Since 2000, two girls under the age of 12, both Hispanic, were logged as unsolved murders in Pima County, according to a national homicide database kept by the FBI. Both had been shot with a pistol.

The first girl was 6, was killed in October 2007 and investigated by the Pima County Sheriff’s Department, according to FBI data. The other girl was 8, died in July 2008, and was investigated by the Tucson Police Department.

The FBI reported no cases of boys under the age of 12 whose murders went unsolved.

Magnus said investigators were again asking for the public's help in solving the case.

"This is not an ending we would have hoped for, but this is not the end to the case," he said.