Doris Sams, who pitched a perfect game and set a single-season home run record in the women’s professional baseball world of the 1940s and 50s that inspired the movie “A League of Their Own,” died Thursday in Knoxville, Tenn. She was 85.

The cause was complications of Alzheimer’s disease, said her cousin Gordon Sams.

Sams was one of the leading players in the All-American Girls Professional Baseball League, founded in 1943 by Phil Wrigley, the owner of the Chicago Cubs, to provide evening entertainment in Midwestern towns and keep interest in baseball alive when the majors were losing most of their players to military service in World War II.

The women’s league, which survived into 1954, was largely forgotten until the 1992 Hollywood comedy with Madonna and Geena Davis on the field and Tom Hanks as the profane manager who drove one of his players to tears and then famously exclaimed in bewilderment, “There’s no crying in baseball!”

The real women’s pro game featured spirited and highly competitive athletes who were often managed by former major leaguers and played through their many abrasions, or “strawberries,” from sliding in their short-skirted uniforms.