Jacksonville Jaguars running back T.J. Yeldon is not practicing with the team on Wednesday, according to Hays Carlyon of the Florida Times-Union.

Yeldon missed every practice preceding the team's Week 6 matchup vs. the Houston Texans, making this the fourth consecutive practice Yeldon has missed since suffering a groin injury. Yeldon did travel to London with the Jags, which presents optimism for his outlook, but it's far from a sure thing that Jacksonville can get their rookie running back in action.

Fantasy impact: Fantasy owners will continue to play the waiting game with Yeldon, who would be replaced by Toby Gerhart and Denard Robinson if he is unable to go. The Buffalo Bills boast one of the league's stingier run defenses, allowing just three rushing touchdowns, 3.8 yards per carry and have allowed the fourth-fewest rushing yards per game.

If Yeldon returns to practice and assumes his usual workload on Sunday, he cannot be considered anything more than a RB2/flex-option despite four teams having their bye weeks. Robinson and Gerhart would be desperate flex-plays in the event Yeldon sits.