MORE than 26,000 litres of alcohol has been lost after two trucks collided in South Australia early this morning.

13,000 litres of Jim Beam bourbon and 13,000 litres of Canadian Club destined for Melbourne spilt onto on to Dukes Highway near Coonaplyn, in the state’s southeast.

That’s enough to fill about 37,000 700ml bottles.

It is believed two trucks - the whiskey truck and a refrigerated truck - clipped each other travelling in opposite directions.

A truck carrying bourbon and whiskey crashed into a semi-trailer in SA on the way to Victoria, causing the rig to flip and burst into flames pic.twitter.com/60RilvzozD — 7 News Melbourne (@7NewsMelbourne) August 23, 2017

The force of the impact caused the vehicle carrying the alcohol to flip and burst into flames.

Both drivers were lucky to escape with non-life threatening injuries in the head-on crash at 2.40am.

One driver, a 42-year-old Queensland man, was flown to Flinders Medical Centre with leg injuries and remains in a stable condition.

The other driver, a 34-year-old man from Victoria, escaped with minor injuries and was treated at the scene.

The highway was closed for several hours but has reopened with speed restrictions in place.

Originally published as 37,000 bottles of Melb-bound booze smashed