According to Donald Trump, Hillary Clinton is crooked, Bernie Sanders is crazy and George Clooney just isn't a good actor.

The presumptive Republican presidential nominee took aim at the movie star in an interview on Fox & Friends Friday morning.

Trump called into the morning show and insulted Clooney's acting ability when asked about the Money Monster star's comment that 'there's not going to be a President Donald Trump'.

'As far as George Clooney is concerned, let's put it this way - he's no Cary Grant,' Trump said.

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Donald Trump said George Clooney (left) is 'no Cary Grant' (right) in an interview Friday on Fox & Friends

The comment was made after Clooney spoke out against Trump at the Cannes Film Festival on Thursday

Trump also addressed Clooney's criticism of the media for relishing the ratings Trump's candidacy has caused, while failing to challenge him on policy.

'Well at least he's right about the ratings - that's the good news,' Trump said. 'I think I get asked the toughest questions on Earth. I will tell you, nobody asks tougher questions than they do to me. It's all "gotcha."'

Clooney, a steadfast Democrat who has helped raise millions for Hillary Clinton's campaign, spoke out against Donald Trump during a press conference at the Cannes Film Festival on Thursday, where he is promoting his new film Money Monster.

'There's not going to be a President Donald Trump,' said Clooney, who held a fundraiser for Hillary Clinton last month in Los Angeles where tickets reportedly went for $353,400 per couple.

'That's not going to happen. Fear is not going to be something that drives our country. We're not going to be scared of Muslims or immigrants or women. We're not actually afraid of anything.'

Clooney went on to say: 'Trump is actually a result in many ways of the fact that much of the news programs didn't follow up and ask tough questions.

'Twenty-four-hour news doesn't mean you get more news, it means you get the same news more. More and more and more you hear these guys, their ratings go up because they can show an empty podium saying "Donald Trump is about to speak," as opposed to taking those 30 seconds and saying, "Well, let's talk about refugees,' which is the biggest crisis going on in the world right now."'

Clooney then tied things back to the film he is promoting by saying: 'This movie is talking about one of the things that I think is a great disaster in the way we inform ourselves right now.

'We've lost the ability to get to and tell the truth and get to the facts.'

Clooney previously spoke out against Trump at the Toronto Film Festival last September, and his comments about Mexicans, saying: 'Anyone who says intolerant words should be laughed at, and I think that's what history will do.'

Cast: Clooney is at Cannes to promote his new film Money Monster (l to r: Julia Roberts, Clooney, Caitriona Balfe and Dominic West)

Money Monster, which is getting mixed reviews, opens this Friday.

The film, which was directed by Jodie Foster and also stars Julia Roberts, Catriona Balfe, Dominic West and Jack O'Connell, was made for $27million and is projected to make a little over $10million in its opening weekend according to The Hollywood Reporter.

Critic Todd McCarthy wrote in his review that the movie 'emerges as a pretty ordinary film about an extraordinary predicament, one in which the writers contrived to bring all the principals together down on Wall Street.

'The wrap-up, and the way it too easily employs both comeuppance and tragedy, is rather too neat for real life, and there's a feel-good aspect to it as well in the way the sneaky, morals-free culprit is forced to be held to account in the most public and embarrassing way possible.