Police and customs officials have made four more arrests in a major crackdown on one of Australia's largest illegal tobacco importation syndicates.

Four people were arrested in Melbourne and charged over the importation of cigarettes and tobacco from countries including Indonesia and the United Arab Emirates.

Six people were charged earlier this year.

Victoria Police Assistant Commissioner Steve Fontana says over the course of the investigation, 71 tonnes of tobacco and 80 million tobacco sticks were seized.

"This equates to about $67 million of tax evasion," he said.

He said more arrests are possible both domestically and overseas.

"We're targeting ... quarantine controls," he said.

Assistant Commissioner Fontana said the cigarettes were sent to Australia hidden in noodles containers.