A man suspected of killing a nurse in a hit-and-run crash and who was behind the wheel in another crash years ago that killed his friend has been arrested after a three-day police hunt.

Sebastian Kennett, 20, has been on the run since he allegedly smashed a stolen white Lexus into a Toyota Yaris in Oakleigh on Monday night, killing the driver, 53-year-old nurse Lynda Hansen, who was on her way home from work.

He was arrested with two other men at a house in Fulton Road in Blackburn South on Thursday night.

The three men are being interviewed by police and no charges have been laid.