ECG, serum electrolytes, creatinine, thyroid stimulating hormone (TSH), and glucose are routinely checked. However, these and other tests are usually of little benefit unless suggested by specific symptoms.

The dose of a suspected drug may be reduced or the drug stopped to confirm the drug as the cause.

Tilt table testing may be done when autonomic dysfunction is suspected; it gives more consistent results than supine and upright BP assessment and eliminates augmentation of venous return by leg muscle contraction. The patient may remain upright for 30 to 45 minutes of BP assessment.

Patients with autonomic symptoms or signs require further evaluation for diabetes, Parkinson disease, and possibly multiple system atrophy and pure autonomic failure. Testing for pure autonomic failure may require plasma norepinephrine or vasopressin (ADH) measurements with the patient supine and upright.