Esdeath (Akame ga Kill) tremendous willpower allows her to suppress the dangerous insanity-inducing side effects of the Demon's Extract.

Tatsumi (Akame Ga Kill) managed to resist the Tyrant's control through incredible will and resolve, stemming from his fusion of the Demon Armour Incursio.

Eren Yeager (Attack on Titan) has shown great determination even in the most horrific moments.

Guts (Berserk)

Saya Otonashi (Blood+) was able to stave off her next hibernation period for some time through sheer willpower alone.

Inoue Orihime (Bleach) has a deeply hidden will that cannot be countered by anyone as noted by Kurōdo and the Shun-Shun Rika's themselves for as long as she believes in herself that she's powerful enough to defeat anyone then she can do it.

Ichigo Kurosaki (Bleach)

Son Goku (Dragon Ball series) possesses an immense drive to win and grow stronger, but after he collided with his own Spirit Bomb in the Tournament of Power, Goku pushed through all his physical and mental barriers out of sheer willpower, achieving a state of being beyond even gods.

Vegeta (Dragon Ball series) possesses an immense drive to win and grow stronger, enabling him to not only resist a mind control that not even the Demon King could resist but also achieve power beyond even gods simply because of his sheer determination to win the Tournament of Power and restore his race.

Frieza's (Dragon Ball series) sheer will to live allows him to survive injuries even the Eternal Dragon believed he would not be able to survive. Likewise, his determination to best Son Goku allowed him to not only resist the tortures of hell but grow vastly stronger because of it.

One of Naruto Uzumaki's best-known traits is his will to never give up, even when near death.

Though his terminal illness had damaged his body to where it should be impossible to move, Kimimaro (Naruto) has devised a way to force himself to move through sheer willpower.

Though his terminal illness was eating away at him, Itachi Uchiha (Naruto) managed to stay alive for many years through medicine and strong willpower.

Monkey D. Luffy (One Piece) has a tremendous will, to the point of defying death in order to defeat his opponents.

Surviving various tortures since childhood, never breaking in nor begging, but instead swearing revenge, Donquixote Doflamingo (One Piece) possesses an incredible drive to live.

Jinbe's (One Piece) tremendous willpower allows him to completely suppress any emotions of fear.

Charlotte Katakuri (One Piece) is fueled by an unbreakable resolve to protect his family which is the source of his strength protecting the ones he cares about.

Saitama (One Punch Man) became the formidable hero he is today because he never gave up on his word on becoming a hero an

Nunnally vi Britannia (Code Geass) was able to break the effects of her father's Geass, which rendered her blind, through her will alone.

Gintoki Sakata (Gintama) has a powerful will enough to endure the white curse during his fight against Enmi.

With all of MÄR-Heaven relying on him as the captain of the team that's protecting the world, no matter what, Ginta (Marchen Awakens Romance) never quits.

Due to Ginta's encouragement, even when the odds are clearly against her, Snow (Marchen Awakens Romance) never concedes a fight.

The Major (Hellsing) resists the temptation of turning into a vampire by sheer will power.

Tigrevurmund Vorn (Madan no Ou to Vanadis) will and resolve to protect the ones he loved allow him to overcome the greatest dangers.

Part of the requirements for becoming a Desperados (Rakudai Kishi no Cavalry) is having the will to overcome one's own fate, something few can do.

Yuudai Moroboshi (Rakudai Kishi no Cavalry) strength lies in his powerful will, having pushed himself through a hellish rehabilitation until he got better and eventually became the Seven Star Sword King.

After merging with Migi's cells and surviving multiple near-death experiences, Shinichi Izumi (Parasyte) gained a high level of mental resilience.