A 64-year-old man has died after sustaining serious injuries on the Roy Hill iron ore mine in Western Australia's remote Pilbara.

Key points: The employee of DIAB Engineering sustained serious injuries following an accident at the Roy Hill site early Monday morning

The employee of DIAB Engineering sustained serious injuries following an accident at the Roy Hill site early Monday morning The contractors are assisting Roy Hill and the relevant statutory authorities with investigations

The contractors are assisting Roy Hill and the relevant statutory authorities with investigations Support has been extended to the worker's family and his colleagues

Gina Rinehart's Roy Hill mine, located 115 kilometres north of Newman and 340km south east of Port Hedland, is the country's largest privately owned mine.

NRW Holdings confirmed the man, who was an employee of its subsidiary DIAB Engineering, sustained serious injuries following an accident on the site early Monday morning.

The man was flown to Perth by the Royal Flying Doctor Service but died in hospital overnight.

In a statement released to the ASX, NRW Holdings said it was "devastated by the loss".

"[We] extend our sincerest condolences to his family, friends and colleagues," the statement said.

"NRW's number one priority is the safety and well-being of our workforce.

"Support has been extended to the worker's family and his colleagues."

The statement said NRW and DIAB were assisting Roy Hill and the relevant statutory authorities with investigations into the accident.

Roy Hill declined to comment, but in a statement said it was "saddened" by the incident "during which an individual was fatally injured".

Two inspectors from the WA Department of Mines, Industry Regulation and Safety are travelling to the site as part of an investigation into the death.

A report is being prepared for the coroner.