“The average Latino in Nevada heard from our campaign 22 times, and we showed that works,” Mr. Rocha said. “We’re experiencing something we’ve never experienced before, and we want to build something that has never been built before.”

The pandemic, and its lasting health and economic effects, will pose challenges, however. Though the demographics of infection rates have been uneven, early indicators suggest that Latinos are seeing a disproportionate spike. In Boston, doctors at Massachusetts General Hospital reported last week that nearly 40 percent of coronavirus patients were Latino, though they typically make up less than 10 percent of patients in the hospital. And in New York City, Latinos are dying from the coronavirus at twice the rate of white people, according to preliminary data released by city officials.

“This climate is enormously complex and these are families with tremendous needs,” said Eric Rodriguez, who oversees policy and advocacy for UnidosUS, a nonprofit that has spent months organizing voters across the country. “We are going to have an election in a moment when we are really focused on leadership and I think what we are starting to see for sure is more outrage at the way political leaders are acting. The more that outrage intensifies, the more work there is for us to do telling people how to use that politically.”

Several Latino activists say they are disseminating information about health and safety for now, but are preparing to pivot to make the case that the Trump administration’s handling of the crisis has further endangered their communities.

“We have to brace ourselves for the fact that there is going to be devastation in black and brown communities — and we need to connect that to the ballot box,” said Maria Teresa Kumar, the chief executive of the nonprofit group Voto Latino, which backed Mr. Biden on Thursday, the first time the group had endorsed a presidential candidate. “There is no better moment to do that.”

Many Latino activists are also pressing for Congress to include benefits for undocumented immigrants in a fourth recovery package, a position that has also been pressed by Mr. Sanders, who dropped out of the presidential race last week. So far, the benefits have excluded any households that pay taxes using an Individual Taxpayer Identification Number, as undocumented workers do — leaving an estimated 12 million people ineligible.