It has become more challenging to get into large chains, due to competition, volume constraints and price, Soble said. Though he nodded to Anheuser-Busch as the biggest hurdle, other craft breweries have bulked up with the help of benefactors, such as Grand Rapids’ Founders Brewing, which sold a 30 percent stake to Spain’s largest beer company, Mahou, in 2014. Also, Lagunitas has sold to Heineken and Ballast Point was acquired by Constellation Brands, maker of Corona, Modelo and other leading Mexican beers.