A wrong-way driver caused a fiery two-vehicle crash overnight that has closed a portion of Interstate 490 in Perinton for more than six hours.

The head-on crash occurred about 1:45 a.m. Wednesday in the highway's eastbound lanes, between the Route 31 and Bushnell's Basin exits. The eastbound lanes reopened at 8 a.m., said Cpl. John Helfer of the Monroe County Sheriff's Office.

A sedan driven by Marissa Pecora, 26, of Webster was driving west in the eastbound lane and crashed into an eastbound tractor-trailer hauling frozen food, which became fully engulfed in flames, Helfer said.

The truck driver, Travis A. Britt, 39, of Georgia, escaped the rig and was not seriously injured, Helfer said.

Deputies are investigating to determine if drugs or alcohol were factors in the crash. Helfer said. Pecora's car was outfitted with an ignition interlock device.

According to the Ontario County District Attorney's Office, Pecora was convicted of driving drunk in April, three months after she was arrested in Farmington. Her driver's license was revoked for six months following the misdemeanor DWI conviction. Her license was reinstated in October.

Court records showed that she was required to have an interlock device on her car for a year.

Emergency responders found Pecora unconscious and trapped inside her car early Wednesday morning. Bushnell's Basin firefighers removed Pecora from her vehicle. Pecora and Britt were both taken to Strong Memorial Hospital for treatment and were being evaluated in the emergency department Wednesday morning.

Between 30 and 40 gallons of gasoline leaked from the tractor-trailer, deeming a Level 0 hazmat situation, Helfer said.

Charges are pending, Helfer said.

This is a developing story. Check back for information as it becomes available.

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VFREILE@Gannett.com