UBO seems to break middle-button clicks to open in new tab running latest public-release Chrome on Win10. I don’t run other browsers so I haven’t tested it elsewhere. No errors are thrown in the console. No UBO changes from the defaults, I actually just installed it a couple days ago (I was running the older uBlock, not realizing it had been discontinued).

When UBO is disabled, middle-button works normally.

When enabled, sometimes middle-button opens the link in a new tab, sometimes it takes two to four clicks, other times it doesn’t work at all. Tested across a wide variety of sites – Google search results, Stackoverflow links, links in various discussion forums, etc.