Osaka University, Medical Xpress, February 5, 2019

The genetic and genomic revolutions have led to an abundance of data about the genetic factors that confer a predisposition to type 2 diabetes (T2D), alongside environmental and lifestyle-related causes. However, most of the studies were based on individuals of European descent, meaning that the findings, and any treatments based on them, may not be optimal for other ethnic groups.

A new study performed by researchers from Osaka University, The University of Tokyo, RIKEN, and others, and published in the journal Nature Genetics has shed more light on the genetics of diabetes in the Japanese population by analyzing data on over 36,000 sufferers of T2D and over 150,000 controls of Japanese ancestry. Their work has revealed 28 novel genomic regions associated with T2D, as well as related molecular pathways and cells, with some of these associations being specific to individuals of Japanese descent.

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“We incorporated the data on links between type 2 diabetes and over 12 million variants across the whole genome from four different genome-wide association studies in the Japanese population,” Yukinori Okada says. “We found 88 genomic regions significantly associated with this disease, including 28 new ones, some of which are not found in European populations in previous reports.”

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“Our findings indicate that some of the genetic underpinnings and molecular pathways of type 2 diabetes in the Japanese population may differ from those in European populations, which is unsurprising considering that, when comparing individuals of the same body mass index, Japanese are more prone to this disease,” lead author Ken Suzuki says. “Our work could lead to Japanese- or Asian-specific therapeutic measures being developed to more effectively prevent or treat diabetes in this ethnic group.

[Editor’s Note: The original story contains graphs and charts. The complete study is available here for a fee.]