A teenager has been rushed to hospital after being stabbed multiple times at a party in Melbourne.

Police said the 18-year-old victim got into an argument with another youth in Aspendale in the city's southeast about 1am.

A brawl erupted between up to ten people, and the victim, from Langwarrin, was stabbed multiple times by an unidentified man who then ran off, police said in a statement.

The altercation started between two groups of youths. (9News)

Police at the house in Aspendale after a teen was stabbed multiple times. (9News)

Friends of the victim bundled him into a car before flagging down an ambulance on the Frankston Freeway on their way to hospital.

An Ambulance Victoria spokesperson said the teen was treated for upper body injuries before being taken to Alfred Hospital in a serious condition.