There's a moment in Tig Notaro's now-legendary 2012 standup set at the Largo in Los Angeles where she considers the perfect absurdity of making an online dating profile.

This was The Set, after all, that career-defining performance that changed everything after Notaro opened with, "Good evening. Hello. I have cancer," and then for 30 minutes wrung tense humor from her mother's recent death via a freak accident, her own health issues that included at the time not one but two life-threatening illnesses, and the cherry, a fresh breakup with her serious girlfriend.

I have cancer. Serious inquiries only, she imagined her hypothetical dating profile reading, taking a long pause as she seemed to think it over, before continuing. "I don't know! That's all I have going on now."

That's not the case anymore. Notaro, who comes to Tampa on Friday, has lots of other stuff going on now, including a wife and twin babies (whom she has at least once dressed in matching Sia wigs). She's healthy, and has also been filming the second season of her Amazon series and continuing to tour almost nonstop.

Her performance at the David A. Straz Jr. Center for the Performing Arts is a chance to catch this master of bone-dry, low-key observations at a crucial turning point in her career/life: Things are actually looking up. But after several years of Notaro's comedy springing forth from tragedy, what's that even going to look like?

Back in 2012, Louis C.K., hottest comic on the planet, proclaimed The Set one of only a "handful of truly great masterful standup sets" he had ever seen. He released it via his website as the album Live, pronounced with a soft I, as if willing her to survive.

The hit album catapulted Notaro to a new level of fame and success, plus a slew of opportunities, all inexorably tied to this sad moment when everything had gone horribly wrong.

There was the 2015 Netflix documentary, Tig, which followed her cancer treatment and her heartbreaking struggle to have children. Her Amazon sitcom One Mississippi, about a radio DJ with cancer, heading home to the South where her mother is dying, premiered in 2016. Last year's book, I'm Just a Person, was marketed as a "darkly funny, wryly observed, and emotionally raw account of her year of death, cancer, and epiphany."

Even as her most recent TV special, Boyish Girl Interrupted, saw Notaro return to lighter material about chasing Santa Claus and accidentally going on stage with an ice cream mustache, the show peaks with jokes about visiting her mother's grave and, more notably, the moment Notaro strips off her shirt and performs with her mastectomy scars showing.

"An album, a book, a movie and a TV show. I think I've … really gotten it out there," she deadpanned in a recent interview with Inbound Studio, when asked about her dark material from The Set. "I did get a lot of attention for that set about everything I'd gone through, and I started to think at times, 'Yeah, I guess that's my thing now,' but I also love silliness, and I'm getting in touch with that more so in my new material that I've been working on."

Notaro first performed in Tampa in 2004, not long after her debut on Comedy Central Presents, a major career highlight at that point. Her most popular bit back then was about a hot dog toaster sold in Skymall catalogs, as serious as it got.

It was early enough in her career that the shock of a fan recognizing her at a Bennigan's in Louisiana had inspired a blog post on her site sarcastically titled "Is there no place to hide?" just a month earlier.

By the time she returned in 2011 to play the tiny New World Brewery in Ybor, she was a cult favorite, adored by the cool kids for her weird, terse delivery, arbitrary topics, and doing things like performing in fan's living rooms, and releasing the DVD "Have Tig at Your Party," which was mostly video of her looking silently into the camera (the joke was people could put it on at a party, and pretend she was a guest).

When she came back to Tampa Bay in 2015 to play the Side Door at the Palladium in St. Petersburg, she was firmly riding the wave of The Set's tragicomedy, and firmly within the rankings of Rolling Stone's 50 Funniest People list.

We don't know where her material will be coming from this time around. She has given some interviews, but has kept her topics vague, and new standup hasn't appeared online or on TV since Boyish Girl.

For someone known for sharing so much of her personal story, she's very quiet on social media these days. Her verified Twitter account has been handed over to her comedian friends, who take turns "being Tig" for a day, posting their own jokes, and at the end of their turns, promoting their own accounts.

The @therealfluffnotaro Instagram account offers only a slightly clearer glimpse into her life now. The bio reads "I am a cat living with lesbians and their twin baby boys," and is mostly pictures of Notaro's cat, with occasional appearances by her wife, Stephanie Allynne, and the twins.

A few months ago, after Stephen Colbert noted during Notaro's Late Show appearance that she has two new children and that parenthood is a pretty common topic for comics, she joked "Prepare yourself, that's all I'm going to talk about." Don't count on that.

She's also coming to Tampa a month after making headlines for pointing out publicly that Louis C.K.'s clown sketch on Saturday Night Live was a little too similar to her own short film Clown Service, though conflict has never been part of her comedy either.

Notaro has said that she's working toward a new special featuring the material on her current tour, and she has been filming Season 2 of One Mississippi, which, like her standup, appears headed in a fresh, new direction.

She has described it to Entertainment Weekly as "somehow more honest while being more fictional than Season 1 was," and called her new standup "the most fun and free I've felt on stage in years," from a person who is "happy, healthy."

Whatever shape that standup takes in Tampa on Friday, it's sure to be unique to Notaro's slightly aloof style, with that off-kilter timing, and the absurdist wit — the things that haven't really changed since the beginning.

Anyone who can spin laughs from a place as unexpected as cancer, should be able to spin something fresh from softballs as expected as motherhood, cats and marriage.

Contact Christopher Spata at cspata@tampabay.com. Follow @SpataTimes.