Story highlights Jeb Bush and Donald Trump clashed over Syrian refugees, with Trump saying he'd boot them from the United States

Trump also called Bush's friendship with Marco Rubio "political bulls***"

Bedford, New Hampshire (CNN) Jeb Bush and Donald Trump clashed over how to handle the Syrian refugee crisis -- and just about everything else, including whether Bush is really friends with Marco Rubio -- during dueling Wednesday night town hall events in New Hampshire.

By the end of the night, Bush had even told Trump to put on his "big boy pants."

In their most substantive policy dispute, the two disagreed sharply over whether refugees who fled the Middle East amid ISIS' rise should be allowed in the United States.

"I think we're duty-bound to provide support," Bush said in Bedford.

Down Route 101 in Keene, Trump called the refugees a "tactical ploy," suggesting that "they could be ISIS, I don't know."

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