WASHINGTON — Sen. Charles Schumer will take aim at President-elect Donald Trump’s favorite mode of communication during his first speech Tuesday as the newly minted Senate Democratic leader.

“With all due respect, America cannot afford a Twitter presidency,” Schumer will say, according to excerpts obtained by The Post.

“We have real challenges and we need to get real things done. Many Americans are afraid, Mr. President-elect, that instead of rolling up your sleeves and forging serious policies … that, for you, Twitter suffices.”

Issues — such as creating jobs, raising incomes and growing the economy — require careful consideration and action and “we cannot tweet them away,” Schumer will say.

Schumer is slated to deliver his floor speech this afternoon after being sworn in to his fourth term. His colleagues last year elected him to succeed Harry Reid as Senate minority leader.

The longtime Brooklyn politician who once counted Trump as his political donor pledged to hold the president-elect accountable.

“Make the lives of Americans better,” Schumer is expected to say. “We will hold him accountable for that. And we will resist him if he breaks that promise.”

Democrats won’t be a “rubber stamp” but are willing to work with him in “good faith” on issues like infrastructure, trade, and closing the carried interest loophole.

Tuesday is the first day of the new GOP-led Congress, where new and re-elected members of the Senate and House will be sworn in and Speaker of the House Paul Ryan formally re-elected leader.

In his new role, Schumer is leading the charge to rally Democratic messaging and opposition. He’ll preview Democratic resistance to Trump’s cabinet picks, which he’s panned as belying Trump’s mantra of “draining the swamp.”