“Angels in America,” Tony Kushner’s sweeping masterwork, will be revived at the Neil Simon Theater next spring, a quarter century after its winged title character first hovered over a Broadway stage.

The revival will star Nathan Lane, the acclaimed stage actor (“The Producers”), as the anti-Communist lawyer Roy Cohn, as well as Andrew Garfield (“Hacksaw Ridge,” “The Amazing Spider-Man”) as Prior Walter, a gay man with AIDS, and Denise Gough (“People, Places and Things”) as Harper Pitt, a Mormon woman with a fondness for Valium.

But the real star is the two-play drama itself, a staggeringly ambitious look at identity, illness and Americanness, set against the backdrop of the AIDS crisis and the Reagan administration. The plays, with the subtitle “A Gay Fantasia on National Themes,” are among the most important American theater works of the 20th Century; the first play, “Millennium Approaches,” won a Pulitzer Prize, and both (the second is called “Perestroika”) won Tony Awards for best new play.

The revival, directed by Marianne Elliott (“The Curious Incident of the Dog in the Night-Time”), was created by the National Theater in London, and was staged there earlier this year. It is scheduled to begin previews on Broadway Feb. 23 and to open March 21; the New York run, produced by Tim Levy of NT America and Jordan Roth of Jujamcyn Theaters, is scheduled to last 18 weeks.