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A flagship pot palace unofficially touted as the “Barneys of weed” is set to open on Fifth Avenue in Manhattan.

LA cannabis brand MedMen will launch a 2,000-square-foot medical marijuana dispensary on — when else? — April 20.

(For the uninitiated, “420” is code for lighting up.)

It will be located at 433 Fifth Ave., near Bryant Park.

Under New York law, MedMen will only service medical patients who are state residents and qualify medically. The marijuana mecca by Adam Bierman and Andrew Modlin offers private label products from gel caps to vape pens.

Currently, MedMen will be one of just three dispensaries legally permitted to operate in Manhattan.

The brand’s employees wear T-shirts with logos such as “Shop. It’s legal” — as long as you are a patient with a letter from a registered NYC physician.