The Yankees are getting more use out of their MRI machine than they are from some from their most important regulars.

Over the course of 24 hours Thursday to Friday, it delivered a double whammy.

The latest test Friday revealed a setback for Dellin Betances, who will be shut down three more weeks after getting a cortisone shot in his right shoulder on Saturday. The reliever has had a bone spur in the back of his right shoulder since he signed with the Yankees in 2006, general manager Brian Cashman said Friday night, but Betances had never dealt with inflammation around it until now.

The 31-year-old was rehabbing a shoulder impingement in Tampa and struggled in a simulated game Thursday. He flew back to New York on Friday for another MRI exam with dye contrast, which revealed the inflammation near the bone spur as the source of irritation.

“There’s optimism, from our team physician, that [the shot] will resolve the issue,” Cashman said as the Yankees’ rain-shortened 9-6 loss to the White Sox was being called. “It could have been much worse news.”

Betances, who was battling diminished velocity in spring training, will be shut down for three weeks, and Cashman said it could be six or seven weeks before he is back pitching for the Yankees.

“There’s no question that’s a blow,” manager Aaron Boone said.

Earlier on Friday, Gary Sanchez joined Betances — and 10 other Yankees — on the 10-day injured list with a left calf strain. The catcher had complained of leg tightness earlier in the week, but was surprised when Thursday’s MRI revealed a “small strain.” He is hopeful he will miss only the minimum 10 days before returning to play, treating the injury now instead of letting it linger and potentially turn into a longer absence.

“I was feeling fine and good to play,” Sanchez said through an interpreter. “The way you feel and where we are as a team, you want to play. You want to help out. So that is frustrating, very frustrating.”

Sanchez, who was sidelined by groin injuries last year and underwent offseason shoulder surgery, was batting 11-for-41 (.268) with six home runs and 11 RBIs. He will be shut down before resuming baseball activities Tuesday. Catcher Kyle Higashioka was recalled from Triple-A Scranton/Wilkes-Barre to fill his roster spot while Austin Romine took over starting duties Friday night.

The Yankees are now playing without six everyday starters in their lineup, as Sanchez joined Didi Gregorius (Tommy John surgery), Aaron Hicks (lower back strain), Giancarlo Stanton (left biceps strain), Miguel Andujar (right shoulder strain) and Troy Tulowitzki (left calf strain) on the shelf.

“It’s our reality right now,” Boone said. “The bottom line is we feel like, unlike any other team maybe, we’re equipped to be able to still have success through this.”

The pitching staff has been pillaged as well, and Betances marked the second setback for a hurler who already was on the injured list. Earlier in the week, Luis Severino was diagnosed with a lat strain while rehabbing an inflamed right rotator cuff — which remains a mystery to Cashman.

“We’re trying to piece that together still [how it happened], to be honest,” Cashman said. “I don’t know how a lat strain during his rehab process could have occurred. … It looked like the day before, he had turned the corner. Then all of a sudden, to everybody’s shock and dismay, there’s a Grade 2 lat strain.”

All of the injuries, plus the Yankees’ subpar play from the last remaining regulars and fill-ins, has led to a 5-8 start. Friday’s avalanche of bad medical news and another loss only added to the frustration.

“It’s obviously painful and hurtful in terms of bottom line and running out the players you can possibly run out there,” Cashman said. “The alternatives are stepping in and trying to compete. There’s frustration there because we’re not getting the competitive play from the healthy guys that we should expect at the same time. It’s a double-edged sword right now that we’re dealing with.”