Author, Article and Disclosure Information

Disclaimer: The data reported in this article have been supplied by the United Network for Organ Sharing as the contractor for OPTN. The interpretation and reporting of these data are the responsibility of the authors and should in no way be seen as an official policy of or interpretation by the OPTN or the U.S. government. The Health Resources and Services Administration, U.S. Department of Health and Human Services, oversees the activities of the OPTN contractor.

Acknowledgment: The authors gratefully acknowledge the extensive efforts of staff from the Gift of Life Donor Program (Philadelphia, Pennsylvania) and other organ procurement programs that helped coordinate information about organ donors and HCV genotype specimen collection. They also acknowledge the remarkable efforts of staff at the Molecular Pathology Laboratory at the Hospital of the University of Pennsylvania, who implemented a rapid HCV genotyping method that is available 24 hours a day, 7 days a week. Many transplant staff members at the University of Pennsylvania also made important contributions to the care of THINKER patients. The authors thank Jeff Silber, MD, PhD; Paul Rosenbaum, PhD; and James Sharpe, MS, for assistance with matching and Jane Kearns, MT (ASCP), CHS, for full interpretation of HLA and donor-specific antibody data. The authors also thank the THINKER trial participants and recognize the generosity of the organ donors and their families.

Financial Support: The study was sponsored by a grant from Merck to the University of Pennsylvania. Merck provided funds for study activities as well as elbasvir–grazoprevir. The study also received funding from the Fred and Suzanne Biesecker Foundation at the Children's Hospital of Philadelphia. Dr. Potluri was supported by a Ben J. Lipps research grant from the American Society of Nephrology. The authors maintained full control over data collection, analysis, and interpretation. Drs. Goldberg and Reese led all analyses and take full responsibility for the quality of the data.

Disclosures: Dr. Reese reports grants from Merck, CVS Caremark, AstraZeneca, and Bristol-Meyers Squibb and other financial support from the American Journal of Kidney Diseases outside the submitted work. Dr. Blumberg served on an advisory board for Merck outside the submitted work. Dr. Bloom reports other financial support from Merck, AbbVie, Veloxis, CSL Behring, and UpToDate and grants from CareDx, Veloxis, and Shire outside the submitted work. Dr. Levine reports nonfinancial support from Pfizer outside the submitted work. Dr. Sawinski reports other financial support from Merck outside the submitted work. Dr. Reddy reports grants from AbbVie during the conduct of the study; grants from Gilead, Bristol-Meyers Squibb, Merck, Vertex, Janssen, Conatus, Intercept, and Mallinckrodt outside the submitted work; personal fees from Gilead, AbbVie, Vertex, Bristol-Meyers Squibb, Janssen, Merck, Shionogi, and Dova outside the submitted work; and royalties from UpToDate. Dr. Goldberg reports grants and personal fees from Merck outside the submitted work. Authors not named here have disclosed no conflicts of interest. Disclosures can also be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-0749.

Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Darren B. Taichman, MD, PhD, Executive Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Deborah Cotton, MD, MPH, Deputy Editor, reports that she has no financial relationships or interest to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Catharine B. Stack, PhD, MS, Deputy Editor for Statistics, reports that she has stock holdings in Pfizer and Johnson & Johnson.

Reproducible Research Statement:Study protocol: See Supplement 2. Statistical code: Available from Dr. Reese (e-mail, [email protected]). Data set: Deidentified elements of the study data set will be shared with investigators, with case-by-case review to ensure confidentiality of participants (e-mail, [email protected]).

Corresponding Author: Peter P. Reese, MD, MSCE, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 917 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104; e-mail, [email protected].

Current Author Addresses: Dr. Reese: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 917 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104.

Drs. Abt, Bloom, Potluri, Levine, Porrett, Sawinski, Nazarian, Naji, and Bleicher: Perelman School of Medicine, University of Pennsylvania, One Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104.

Dr. Blumberg: Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 3 Silverstein, Suite E, 3400 Spruce Street, Philadelphia, PA 19104.

Dr. Van Deerlin: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 7.103 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104.

Mr. Hasz and Mr. Suplee: Gift of Life Donor Program, 401 North 3rd Street, Philadelphia, PA 19123.

Dr. Trofe-Clark: Perelman Center for Advanced Medicine, West Pavilion, 2nd Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104.

Ms. Sicilia and Ms. McCauley: Perelman School of Medicine, University of Pennsylvania, 729 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104.

Ms. Gentile and Ms. Smith: Molecular Pathology Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, 3400 Spruce Street, Philadelphia, PA 19104.

Mr. Niknam: Center for Outcomes Research, The Children's Hospital of Philadelphia, 2716 South Street, Room 5121, Philadelphia, PA 19146.

Dr. Reddy: Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, 2 Dulles, 3400 Spruce Street, Philadelphia, PA 19104.

Dr. Goldberg: Perelman School of Medicine, University of Pennsylvania, 730 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104.

Author Contributions: Conception and design: P.P. Reese, P.L. Abt, E.A. Blumberg, V.M. Van Deerlin, R.D. Bloom, D. Sawinski, L. Suplee, M. McCauley, M. Bleicher, K.R. Reddy, D.S. Goldberg.

Analysis and interpretation of the data: P.P. Reese, E.A. Blumberg, R.D. Bloom, V.S. Potluri, M. Levine, R. Hasz, J. Trofe-Clark, C. Gentile, B.A. Niknam, M. Bleicher, K.R. Reddy, D.S. Goldberg.

Drafting of the article: P.P. Reese, P.L. Abt, E.A. Blumberg, R.D. Bloom, V.S. Potluri, M. Bleicher, D.S. Goldberg.

Critical revision of the article for important intellectual content: P.P. Reese, P.L. Abt, E.A. Blumberg, V.M. Van Deerlin, R.D. Bloom, V.S. Potluri, M. Levine, D. Sawinski, S.M. Nazarian, J. Trofe-Clark, B.A. Niknam, M. Bleicher, K.R. Reddy, D.S. Goldberg.

Final approval of the article: P.P. Reese, P.L. Abt, E.A. Blumberg, V.M. Van Deerlin, R.D. Bloom, V.S. Potluri, M. Levine, P. Porrett, D. Sawinski, S.M. Nazarian, A. Naji, R. Hasz, L. Suplee, J. Trofe-Clark, A. Sicilia, M. McCauley, C. Gentile, J. Smith, B.A. Niknam, M. Bleicher, K.R. Reddy, D.S. Goldberg.

Provision of study materials or patients: P.L. Abt, M. Levine, P. Porrett, S.M. Nazarian, R. Hasz, M. McCauley.

Statistical expertise: P.P. Reese, V.S. Potluri, B.A. Niknam, D.S. Goldberg.

Obtaining of funding: P.P. Reese, D.S. Goldberg.

Administrative, technical, or logistic support: P.P. Reese, P.L. Abt, R.D. Bloom, P. Porrett, D. Sawinski, L. Suplee, A. Sicilia, C. Gentile, J. Smith, B.A. Niknam, M. Bleicher, D.S. Goldberg.

Collection and assembly of data: P.P. Reese, V.M. Van Deerlin, V.S. Potluri, M. Levine, P. Porrett, R. Hasz, A. Sicilia, M. McCauley, C. Gentile, M. Bleicher, D.S. Goldberg.