Motorists have been warned to expect traffic and public transport disruptions in Sydney's CBD and the lower north shore in coming days during the visit of US Vice President Mike Pence and his family.

Special event clearways will be enforced on the city's roads and the number of police officers on the city's streets boosted during the Australian leg of Mr Pence's Asia-Pacific tour.

Mr Pence, his wife wife, Karen, and two daughters, Charlotte and Audrey, are due to fly into Sydney late on Friday and will spend the weekend in the city, before embarking for Hawaii on Monday.

As well as meeting with Australian officials, Mr Pence and his delegation are expected to visit Sydney's tourist sites, including taking a cruise on Sydney Harbour.