Isis militants fleeing from Syria as their so-called caliphate crumbles could potentially use chemical weapons when they return to their countries of origin, the Organisation for the Prohibition of Chemical Weapons (OPCW) has warned.

“It seems that one of the dangers that we need to face and have a response for - since Isis has learnt how to make mustard gas - is that sadly one of the people who learnt how to do it comes back to one of our countries and helps carry out an attack like this,” Philippe Denier, director at the verification division of the OPCW told a defence conference in Paris on Wednesday.

Intelligence services suspect that Isis has used sites all over Iraq and Syria to manufacture rudimentary versions of sulfur-mustard blister agents, which are banned under international law.

Mustard gas is a powerful irritant that targets the skin, eyes and airways, and can kill in large enough or highly concentrated enough amounts. Symptoms can take up to 24 hours to appear.

An October inquiry from the global chemical weapons watchdog and the UN found that Isis had used the weapon on civilians.

After rockets containing traces of mustard gas were used on US troops in northern Iraq in September, Marine General Joseph Dunford, chair of the Joint Chiefs of Staff, told the US Senate’s Armed Services Committee that while Isis’ capabilities are currently “rudimentary” the attack was a “concerning development.”

No one was harmed in the incident, but a new analysis this week from IHS Markit, a London-based intelligence analyst firm, found that there is a “high risk” Isis will use chemical agents on civilians and coalition forces as the battle for control of the Isis-held Iraqi city of Mosul intensifies.

In pictures: Mosul offensive Show all 40 1 /40 In pictures: Mosul offensive In pictures: Mosul offensive A doctor carries an Iraqi newborn baby at a hospital in Mosul, Iraq July 18, 2017. Reuters In pictures: Mosul offensive Iraqi girls play at a yard of a school in Mosul, Iraq July 18, 2017alal Reuters In pictures: Mosul offensive A woman on crutches who is a relative of men accused of being Islamic State militants is seen at a camp in Bartella, east of Mosul, Iraq July 15, 2017. Picture taken July 15, 2017. Reuters In pictures: Mosul offensive A displaced girl, who fled from home carries a doll at Hamam al-Alil camp south of Mosul, Iraq July 13, 2017. Reuters In pictures: Mosul offensive Iraqi federal police members and civilians celebrate in the Old City of Mosul on 9 July 2017 after the government's announcement of the "liberation" of the embattled city. Iraqi Prime Minister Haider al-Abadi's office said he was in "liberated" Mosul to congratulate "the heroic fighters and the Iraqi people on the achievement of the major victory" AFP/Getty Images In pictures: Mosul offensive A picture taken on 9 July 2017, shows a general view of the destruction in Mosul's Old City. Iraq will announce imminently a final victory in the nearly nine-month offensive to retake Mosul from jihadists, a US general said Saturday, as celebrations broke out among police forces in the city. AFP In pictures: Mosul offensive Members of the Iraqi federal police raise the victory gesture as they ride on a humvee while advancing through the Old City of Mosul on 28 June 2017, as the offensive continues to retake the last district held by Islamic State (IS) group fighters. AFP/Getty Images In pictures: Mosul offensive Smoke billows as Iraqi forces advance through the Old City of Mosul on 26 June 2017, during the ongoing offensive to retake the last district held by the Islamic State (IS) group. AFP/Getty Images In pictures: Mosul offensive An Iraqi man wearing the green scarf of the Shi'ite faith kisses an Iraqi Army soldier on safely reaching the Iraqi forces position as Iraqi civilians flee the Old City of west Mosul where heavy fighting continues on 23 June 2017. Iraqi forces continue to encounter stiff resistance with improvised explosive devices, car bombs, heavy mortar fire and snipers hampering their advance. Getty Images In pictures: Mosul offensive A picture taken from the inside of an Iraqi forces armoured vehicle shows residents walking through a damaged street as troops advance towards Mosul's Old City on 18 June 2017, during the ongoing offensive to retake the last district still held by the Islamic State (IS) group. Military commanders told AFP the assault had begun at dawn after overnight air strikes by the US-led coalition backing Iraqi forces. They said the jihadists were putting up fierce resistance. AFP/Getty Images In pictures: Mosul offensive Iraqi Army soldiers advance in a destroyed street after an Iraqi forces airstrike targeted an Islamic State sniper position 17 June 2017 in al-Shifa, the last district of west Mosul under Islamic State control. IS snipers, as well as car and suicide bomb attacks continue to hinder the Iraqi forces efforts to retake the final district. A series of airstrikes by Iraqi helicopter gunships attempted to hit multiple Islamic State sniper positions in al-Shifa. Getty Images In pictures: Mosul offensive An Iraqi soldier frisks a displaced Iraqi man at a temporary camp in the compound of the closed Nineveh International Hotel in Mosul on 16 June 2017 which was recovered by Iraqi troops from Islamic State group fighters earlier in the year. A screening centre set up in the compound's fairgrounds sees a constant stream of Iraqis fleeing the battle for Mosul, awaiting their turn to be checked by the Iraqi forces who are searching for suspected Islamic State (IS) group members. The small fairground lies at the end of a pontoon bridge across the Tigris recently opened to civilians that is the only physical link between the two banks of the river. AFP/Getty Images In pictures: Mosul offensive Iraqis staying at the al-Khazir camp swim in a river near the camp for internally displaced people, located between Arbil and Mosul on 11 June 2017. AFP/Getty Images In pictures: Mosul offensive Iraqi government forces drive on a road leading to Tal Afar on 9 June 2017, during ongoing battles to retake the city from Islamic State (IS) group fighters. AFP/Getty Images In pictures: Mosul offensive An Iraqi policeman carries a poster bearing an image of Mosul's iconic leaning minaret, known as the "Hadba" (Hunchback), on 22 June 2017. AFP/Getty Images In pictures: Mosul offensive Iraqis stand in line to receive food aid in western Mosul's Zanjili neighbourhood on 7 June 2017, during ongoing battles as Iraqi forces try to retake the city from Islamic State (IS) group fighters. Living conditions in Mosul have again deteriorated since the start of the Iraqi government's offensive on the city in October in which they retook a large part of the west of the city. AFP/Getty Images In pictures: Mosul offensive Displaced Iraqis carry lightbulbs and sacks as they evacuate from western Mosul's Zanjili neighbourhood as government forces advance in the area during their ongoing battle against Islamic State (IS) group fighters on 13 May 2017 AFP/Getty Images In pictures: Mosul offensive A member of the Iraqi Counter-Terrorism Service (CTS) flashes the victory gesture as he patrols in western Mosul's al-Islah al-Zaraye neighbourhood on 13 May 2017 AFP/Getty Images In pictures: Mosul offensive Iraqi army soldiers from the 9th armoured division on a truck flash the sign of victory as they drive back from Mosul to the town of Qaraqosh (also known as Hamdaniya) Getty In pictures: Mosul offensive Members of Iraqi forces flash the sign of victory on their vehicle as they advance towards Hammam al-Alil area south of Mosul Getty In pictures: Mosul offensive A member of Iraqi security forces gestures in Hammam al-Alil, south of Mosul, Iraq Reuters In pictures: Mosul offensive Iraqi children, one flashing the sign of victory, greet Iraqi army's soldiers from the 9th armoured division in the area of Ali Rash, adjacent to the eastern Al-Intissar neighbourhood of Mosul Getty In pictures: Mosul offensive Peshmerga forces look at a tunnel used by Islamic State militants near the town of Bashiqa, east of Mosul, during an operation to attack Islamic State militants in Mosul, Iraq Reuters In pictures: Mosul offensive An Iraqi soldier takes a photograph with his phone as his comrade stands next to a detained man, whom the Iraqi army soldiers accused of being an Islamic State fighter, who was fleeing with his family in the Intisar disrict of eastern Mosul, Iraq Reuters In pictures: Mosul offensive Iranian Kurdish female members of the Freedom Party of Kurdistan (PAK) hold a position in an area near the town of Bashiqa, some 25 kilometres north east of Mosul Getty In pictures: Mosul offensive Iraqi families, who fled their homes in Hamam al-Alil, gather on the outskirts of their town Getty In pictures: Mosul offensive Displaced people walk past a checkpoint near Qayara, south of Mosul, Iraq AP In pictures: Mosul offensive Iraqi families who were displaced by the ongoing operation by Iraqi forces against jihadists of the Islamic State group to retake the city of Mosul, are seen gathering in an area near Qayyarah In pictures: Mosul offensive A boy who just fled Abu Jarbuah village is seen with his family at a Kurdish Peshmerga position between two front lines near Bashiqa, east of Mosul, Iraq Reuters In pictures: Mosul offensive An Iraqi child eats a pomegranate upon the arrival of Iraqi forces in the village of Umm Mahahir, south of Mosul Getty In pictures: Mosul offensive People who just fled Abu Jarbuah village sit as they eat at a Kurdish Peshmerga position between two front lines near Bashiqa, east of Mosul, Iraq Reuters In pictures: Mosul offensive A couple who just fled Abu Jarbuah village are escorted by Kurdish Peshmerga soldiers Reuters In pictures: Mosul offensive Women carry a boy over a wall as civilians flee their houses in the village of Tob Zawa, Iraq AP In pictures: Mosul offensive An Iraqi soldier and a civilian ride a motorbike as smoke rises behind them, on the road between Qayyarah and Mosul Getty In pictures: Mosul offensive A member of Iraqi forces, wearing a skull mask, waits at a checkpoint for people fleeing the main hub city of Mosul Getty In pictures: Mosul offensive An Iraqi soldier sits at a checkpoint in an area near Qayyarah Getty In pictures: Mosul offensive Iraqi men prepare food portions for Iraqi forces deployed in areas south of Mosul Getty In pictures: Mosul offensive Iraqi forces celebrate upon the arrival of vehicles bringing food to them Getty In pictures: Mosul offensive Iraqi childen smoke cigarettes upon the arrival of Iraqi forces in the village of Umm Mahahir, south of Mosul Getty In pictures: Mosul offensive A member of Iraqi forces distributes drinks to children in the village of Umm Mahahir, south of Mosul Getty

Mosul previously served as a major chemical weapons production centre for Isis, the group said, but most of the materials for making chlorine and mustard gas have been moved to the group’s de facto capital of Raqqa in Syria ahead of the fighting.

Isis has used its crude chemical weapons at least 52 times to date, IHS Markit said.