We thank M. Tessier-Lavigne, N. Renier and P. Ariel for help with CUBIC; members of the Zuker laboratory and R. Axel for helpful discussions. We also acknowledge the Bio-Imaging Resource Center at Rockefeller University. Research reported in this publication was supported by the National Institute on Drug Abuse of the National Institutes of Health under award number R01DA035025 (C.S.Z). N.J.P.R. is supported by the Intramural Research Program of the NIH, NIDCR; and C.D.S. was supported by R01 MH082017 from NIMH. C.S.Z. is an investigator of the Howard Hughes Medical Institute and a Senior Fellow at Janelia Farm Research Campus.

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Nature thanks I. de Araujo and P. Kenny for their contribution to the peer review of this work.