Generally no: you need an offer from the source PeerConnection; there's no guarantee that a blob for PC1 can be used with PC2 (and likely can't). Now, if they've created a peerconnection, done CreateOffer, and hold onto the peerconnection until that SDP gets used - then yes, but that' not really "re-use".

You might get away with it, but various things now or in the future might break you semi-randomly. The best solution is to create an offer from the source node, and pass it over the p2p network to the target node, which can then pass a response back. If you can keep a PC alive to wait for incoming transactions, the "source" could use that for createAnswer, and cut one trip through the p2p network. You'd need to deal with collisions (two nodes trying to use the same offer that was distributed through the network; basically a fail/retry setup should handle it in the rare cases it's needed). You can also include with the answer an offer to use just in case there's a collision.