Why They Might Work

China used CQ on a trial of 134 patients in February, finding it was effective in reducing the severity of the illness, according to officials.

But these results haven’t yet been published. Chinese respiratory expert Zhong Nanshan, who leads a government task force in response to the epidemic, said in a press conference last week that the data would be widely shared soon.

In France, a team led by Didier Raoult of the IHU-Mediterranee Infection, Marseille reported last week they had carried out a study on 36 COVID-19 patients, finding that HCQ drastically reduced the viral load in a group which received the drug.

The effects were especially pronounced when it was used with azithromycin, a common antibiotic used to sweep out secondary bacterial infections.

What’s more, HCQ and CQ drugs have been proven to act against the SARS-CoV-2 virus in lab settings, and a paper published by a Chinese team last week in Cell Discovery offered a potential mode of action.

Karine Le Roch, a professor of cell biology at the University of California, Riverside, explained that both HCQ and CQ are weak bases that elevate the pH of parts of human cells called organelles — which are analogous to organs in animals — and which are normally acidic.

This, in turn, interferes with the virus‘ ability to enter the cells — and also seems to block them from replicating once they are already inside.

But, she added: “While it worked in vitro, I am still waiting to see published results of large blind clinical trials demonstrating the efficacy of HCQ in vivo,” she told AFP.