Journalists guilty of gross malpractice should be struck off a professional register to prevent them working in news, the shadow culture secretary will suggest at the Labour conference on Tuesday.

Ivan Lewis is proposing a "system of independent regulation including proper like-for-like redress which means mistakes and falsehoods on the front page receive apologies and retraction on the front page".

He will also warn Rupert Murdoch's News International that Labour will never allow the corporation to use its media influence to exert political power in pursuit of ideological or commercial goals.

His remarks represent a further break from Murdoch by Labour. Ed Miliband, the party's leader, has been widely praised for taking a risk in condemning the Murdoch corporation over phone hacking.

Lewis will deliver what he describes as a "message for Mr Murdoch" and will say: "Your newspapers and Sky TV are popular with millions of British people. Some people in our movement might find that uncomfortable but it's true.

"However – and yes conference we should have said this a long time ago – never again think you can assert political power or seek political influence in the pursuit of your commercial goals or ideological beliefs. We're not having it. This is Britain, Mr Murdoch. The integrity of our media and our politics is not for sale."

Lewis will suggest that newspapers should introduce a system whereby journalists could be struck off a register for malpractice. And he will question David Cameron's reluctance to explain why he made Andy Coulson, the former News of the World editor, his communications director both in opposition and then in government. He will say: "I believe in second chances too. So, isn't it time you and George Osborne came clean about Andy Coulson?"

Lewis is also to set out further steps in his creative industry network designed to persuade high profile creative industries to offer their internships, apprenticeships and jobs to applicants based on talent, not background or social networks.

"I am delighted to announce today that the Advertising Association, UK Music, Virgin Media and the Sharp Project have agreed to become the first signatories to our pledge," he will say.