Donald Trump slammed Hillary Clinton saying she made 'the worst mistake of the political season' after describing his supporters as a 'basket of deplorables'.

In a statement Saturday, Clinton backtracked on her comments saying she regrets half of her remarks, after admitting she was 'grossly generalistic' in what she said at the LGBT fundraiser in New York Friday, adding 'that's never a good idea'.

She had called half of Trump's supporters racist, homophobic, sexist, xenophobic, or Islamophobic and said they belonged in a 'basket of deplorables'.

The Republican presidential nominee hit back at her in a series of tweets and a statement after she spoke of her regret.

The Donald said she had made 'the worst mistake of the political season'.

In the statement he added 'her true feelings came out, showing bigotry and hatred for millions of Americans'.

He then retweeted a message President Barack Obama shared back in 2012 which read: 'RT if you agree: We need a President who is fighting for all Americans, not one who writes off nearly half the country.'

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Democratic presidential nominee former Secretary of State Hillary Clinton speaks during he LGBT for Hillary Gala at Cipriani Club on September 9 in New York City where she called half of Trump's supporters racist, homophobic, sexist, xenophobic, or Islamophobic and said they belonged in a 'basket of deplorables'

Clinton shared a statement on Twitter on Saturday afternoon saying she regrets half of her remarks

Trump is pictured speaking during his rally at the Pensacola Bay Center on Friday in Pensacola, Florida

Trump retweeted a message President Barack Obama shared back in 2012 which read: 'RT if you agree: We need a President who is fighting for all Americans, not one who writes off nearly half the country'

Trump called Clinton's comments a 'grotesque attack' and questioned how she can be president when 'she has such contempt and disdain for so many great Americans'.

In her statement the democratic presidential candidate said that, 'many of Trump's supporters are hard-working Americans who just don't feel like the economy or our political system are working for them'.

She also emphasized that it is 'really deplorable' that Trump is affiliated with people from the right-winged 'alt-right movement,' and that 'David Duke and other white supremacists see him as a champion of their values'.

With her statement she tweeted: 'I won't stop calling out bigotry and racist rhetoric in this campaign.'

Trump had also taken a swipe at her on Twitter tweeting: 'Wow, Hillary Clinton was SO INSULTING to my supporters, millions of amazing, hard working people. I think it will cost her at the Polls!'

And he later added: 'While Hillary said horrible things about my supporters, and while many of her supporters will never vote for me, I still respect them all!'

But she bit back again tweeting in response: 'Except for African Americans, Muslims, latinos, immigrants, women, veterans - and any so-called 'losers' or 'dummies'

Trump fired back on Twitter at Hillary saying 'Clinton was SO INSULTING to my supporters' and said 'horrible things'

Clinton bit back at Trump again on Twitter saying 'except for African Americans, Muslims, latinos, immigrants, women, veterans - and any so-called 'losers' or 'dummies'

Trump's supporters were also quick to jump to his defense.

His running mate Mike Pence said Saturday at the Values Voters Summit in Washington that Clinton's comments should be 'denounced in the strongest possible terms'.

He said that Trump supporters are 'not a basket of anything', adding, they are 'members of every class of this country who know that we can make America great again'.

Republican vice presidential candidate, Indiana Gov. Mike Pence speaks to the Value Voters Summit in Washington, Saturday. He said that Trump supporters are 'not a basket of anything'

Pence said, 'the men and women who support Donald Trump's campaign are hard-working Americans: Farms, coal miners, teachers, veterans, members of our law enforcement community'.

And his son Eric Trump also took to Twitter writing: 'Look at the #BasketOfDeplorables in Pensacola Florida last night! What a horrible statement. #CrookedHillary'.

However Mark Cuban, the owner of the NBA's Dallas Mavericks, was quick to point out that the photo he shared of the tweet was actually an old snap taken in Dallas.

Eric Trump rushed to his father's defense tweeting 'what a horrible statement'

However Mark Cuban was quick to point out that Eric Trump had used an old photo which was actually taken in Dallas not Florida as he stated

Clinton's comments also drew a rebuke from Kellyanne Conway, the campaign manager of the Republican nominee, who said in a message on Twitter that Clinton had insulted millions of Americans.

Trump senior communications adviser Jason Miller added in a statement: 'What's truly deplorable isn't just that Hillary Clinton made an inexcusable mistake in front of wealthy donors and reporters happened to be around to catch it, it's that Clinton revealed just how little she thinks of the hard-working men and women of America.'

Clinton's comments drew a rebuke from Kellyanne Conway, pictured above, the campaign manager of the Republican nominee

Conway slammed Clinton on Twitter saying that she had insulted millions of Americans and used the hashtag #desperate

Clinton went on to say in Friday's speech that some of those people were irredeemable, but they did not represent America.

The other basket of Trump's supporters constituted individuals desperate for change who felt let down by the government and the economy, Clinton added.

'They don't buy everything he says, but he seems to hold out some hope that their lives will be different,' Clinton said.

'Those are people we have to understand and empathize with, as well.'

She encouraged supporters to 'stage an intervention' if they have friends considering voting for the Republican nominee.

Clinton spokesman Nick Merrill also took to Twitter to hit back at the Trump campaign's comments

And Clinton spokesman Nick Merrill also weighed into the debate noting a previous speech in which she accused Trump of embracing a brand of U.S. political conservatism associated with white nationalism and nativism known as the 'alt right' movement.

'Obviously not everyone supporting Trump is part of the alt right, but alt right leaders are with Trump,' Merrill said on Twitter.

'And their supporters appear to make up half his crowd, when you observe the tone of his events.'

Tom Lehane, left, a Republican Presidential candidate Donald Trump supporter, has a disagreement with Democratic Presidential candidate Hillary Clinton supporter Hila Minshen prior to a Trump rally at the Pensacola Bay Center in Florida on Friday

Supporters of Republican presidential candidate Donald Trump wait for his arrival to a rally, Friday, in Pensacola, Florida

A young girl waves pom pons in the crowd as Republican presidential nominee Donald Trump speaks at a campaign rally in Pensacola, Florida, Friday

Bikers for Trump! Supporters of Republican presidential nominee Donald Trump listen as he speaks at a campaign rally in Pensacola, Florida, Friday

Many of Clinton's fundraisers have been closed to the media, but her Friday remarks, preceding a performance by singer Barbra Streisand, were open to journalists.

Streisand performed a version of the Stephen Sondheim song 'Send in the Clowns' that parodied the New York businessman, referring to the real estate mogul as a 'sad, vulgar clown'.

Streisand performed a version of the Stephen Sondheim song 'Send in the Clowns' that parodied the New York businessman, referring to the real estate mogul as a 'sad, vulgar clown'. She is pictured during the performance