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This horrifying video captures the moment Syrians ran for their lives after an ISIS suicide bomber blew himself up near a hospital.

Twin explosions in a government-controlled neighbourhood of Homs city killed at least 16 people and wounded scores more on Saturday, state media said, in an attack claimed by the Islamic State .

A huge explosion can be seen towards the right hand side of the screen before the camera loses focus.

People are heard screaming and shouting as they attempt to run to safety through the packed square.

(Image: AFP/Getty Images)

Moments earlier, it is believed the suicide bomber had detonated a car bomb before activating his explosives belt.

The blasts come days after the government extended its control of the western city with the implementation of a truce deal in Waer, the last insurgent-held area of Homs.

Read more:Obama warns ISIS leaders "you are next" as he steps up US bombing campaign

Some fighters and civilians have left Waer on the western side of the city's outskirts., and aid has been allowed in.

A vehicle bomb detonated close to a hospital in the mainly Alawite neighbourhood of al-Zahra in the east of Homs city, the Syrian Observatory for Human Rights monitoring group said.

(Image: AFP/Getty Images)

In a statement posted online, Islamic State described it as a suicide car bomb attack in the centre of Zahra district.

The second large blast, originally suspected to have been a bomb, appeared to have come from an exploding gas canister and hit people who had come to tend to victims of the first explosion in the densely-populated neighbourhood, state media said.

State television had earlier described the attack as "two large terrorist explosions".

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News agency SANA said the vehicle bomb had been packed with 150 kg of explosives. It published a photo of two men carrying a woman away from burning wreckage.

Footage on state television showed a chaotic scene, with black smoke rising above twisted metal debris.

People stumbled over the rubble as they tried to ferry people away from the site.

(Image: AFP/Getty Images)

The attack comes after reports that ISIS have constructed a missile capable of bringing down a jet.

Activists in Syria claim western defectors to ISIS with experience in engineering have managed to successfully create the devastating weapon - which could potentially down aircraft if the reports are true.

Read more:Inside terrifying ISIS dungeon where women prisoners were kept locked UNDER THE DESERT in horrifying conditions

Engineer Rwanda Tahir, a Dane of Iraqi origins, and 'Omar the Chechen', a former Russian military officer, are said to have been instrumental in the creation of the weapon.

Activist group Raqqa Is Being Silently Slaughtered says the terror group wants to carry out more sophisticated terrorist attacks on France, America and Russia.

A military truck was seen carrying a large land-to-air rocket, which was launched in Raqqa - Islamic State 's de facto capital.