The new season of “Saturday Night Live” will have a significant change in its cast and its most prominent segment, “Weekend Update.”

Michael Che, a comic perhaps best known for his role as a correspondent on Comedy Central’s “The Daily Show,” will replace Cecily Strong, who will remain on “S.N.L.” as a regular cast member.

After trying out what he said were “a number of different combinations” in the last few weeks, Lorne Michaels, the show’s creator and executive producer, said he had selected Mr. Che, 31, who worked on the show last season as a writer, to be the partner of Colin Jost, who began co-anchoring “Weekend Update” in the middle of last season.

Mr. Michaels said that Mr. Che, who has had a career as a stand-up comedian in New York, formed a close relationship last year in the writers’ room with Mr. Jost, one of the show’s two head writers.