Author: Alex Koyfman, MD // Editor: Justin Bright, MD

Your next 3 patients…

#1) 23yo MMA fighter with low back pain

#2) 29yo M presents as pedestrian versus auto (“the car bumped my knee and I walked away… now it hurts”)

#3) 34yo M with forearm pain s/p fall off of ladder

–Pathology Cascade: Incr osseofascial compartment pressure from local trauma / soft tissue injury (edema, bleeding) => incr interstitial pressure => decr perfusion => (irreversible) nerve and muscle damage

–Most Common Site: leg (tibial shaft – #1); forearm (#2); hand; foot; thigh; any site where skeletal muscle is covered by fascia is a possibility

–Most Common Patient: Male; less than 35yo

–Causes: fracture, crush injury, GSW, contusion, tight splint/cast, IV infiltration, burn, arterial injury, snakebite, nephrotic syndrome

–Why it’s challenging: can present w/ vague sxs / exam

–Why we care: loss of function / limb

-4 leg compartments

-3 forearm compartments

**Image credit: www.orthobullets.com

Clinical Pearls // Management

–Time is muscle! Time to dx is most important prognostic factor; serial exams are your friend, however understand exam isn’t perfect

–Pain out of proportion/rest pain is usually first symptom (few clinical entities cause this: mesenteric ischemia, deep soft tissue infection, AAA, biliary tract obstruction, bowel obstruction, pancreatitis, stomach/bowel perforation, MI, vascular occlusion, malignant otitis externa)

–not always present or easy to assess (neuropathy, AMS, intubated, polytrauma, young child, unreliable exam)

-important not to treat pain out of proportion to exam as someone opiate seeking

-Most sensitive finding: pain w/ passive stretch; other P’s of compartment syndrome we learned are late findings

(The 6 P’s: pain, paresthesia, pallor, paralysis, pulselessness, poikilothermia)

–Difficult to diagnose in children, thus typically delayed; consider in pt w/ proper context + restlessness / rising opioid requirement (see reference 14 for extended discussion)

-No difference in incidence b/t open vs closed fractures; can develop w/out fracture!!

–4-8 hours is commonly cited cut-off for when irreversible ischemic changes begin to occur (controversial)

-Work-up: XR as indicated; intracompartmental pressure measurements – w/in 5cm of fx site or area of maximal swelling (Stryker, NIRS) for low/medium risk pts; clinical dx in high-risk pts

-Call Gen Surg/Ortho immediately; remove / loosen dressing/splint/cast, elevate extremity, reduce fracture as appropriate

-Usually it is the surgical service doing the intracompartmental pressure measurement; if working in setting without surgical backup, important to know how to do it (https://www.youtube.com/watch?v=rtysrBh7AP0)

–Emergent fasciotomy: clinical dx or compartment pressures 30-45 mm Hg (exact # controversial and test w/ limitations – see reference 4) / compartment pressures within 30 mm Hg of DBP (delta P); controversial if late identification of compartment syndrome

References // Further Reading

1) http://www.ncbi.nlm.nih.gov/pubmed/24686026

2) http://www.ncbi.nlm.nih.gov/pubmed/24560014

3) http://www.ncbi.nlm.nih.gov/pubmed/23816339

4) http://www.ncbi.nlm.nih.gov/pubmed/23321294

5) http://www.ncbi.nlm.nih.gov/pubmed/23340119

6) http://www.ncbi.nlm.nih.gov/pubmed/23200336

7) http://www.ncbi.nlm.nih.gov/pubmed/23200335

8) http://www.ncbi.nlm.nih.gov/pubmed/22981663

9) http://www.ncbi.nlm.nih.gov/pubmed/22325557

10) http://www.ncbi.nlm.nih.gov/pubmed/20005667

11) http://www.ncbi.nlm.nih.gov/pubmed/20925169

12) http://lifeinthefastlane.com/ortho-library/compartment-syndrome/

13) http://lifeinthefastlane.com/bone-and-joint-bamboozler-002/

14) http://pedemmorsels.com/compartment-syndrome/

15) http://www.epmonthly.com/departments/cme/cme-archive/diagnosing-compartment-syndrome/

16) https://www.youtube.com/watch?v=rtysrBh7AP0