An operation targeting the supply and distribution of cocaine and other illicit drugs in Sydney's eastern suburbs has led to 55 people being charged with drug supply and possession.

Over the course of six nights this month, police from Strike Force Northrop allegedly seized more than 290 grams of cocaine, 13 grams of MDMA, 110 grams of cannabis and $63,000 in cash. They charged 28 people with drug supply and 27 with drug possession.

Strike force detectives were assisted by officers from Surry Hills, Sydney City, Kings Cross, Eastern Suburbs and Eastern Beaches Police Area Commands, and the Dog Unit, to carry out a series of vehicle searches in Bondi, Paddington and Coogee on Friday and Saturday nights.

On the weekend of May 10 and 11, eight people were arrested and charged following five separate vehicle stops.