Six Republican senators crossed the aisle on Thursday to vote with Democrats and advance a stopgap measure that would end the partial government shutdown without additional funding for President Trump Donald John TrumpObama calls on Senate not to fill Ginsburg's vacancy until after election Planned Parenthood: 'The fate of our rights' depends on Ginsburg replacement Progressive group to spend M in ad campaign on Supreme Court vacancy MORE's proposed border wall.

GOP Sens. Lamar Alexander Andrew (Lamar) Lamar AlexanderChamber of Commerce endorses McSally for reelection Trump health officials grilled over reports of politics in COVID-19 response Now is the time to renew our focus on students and their futures MORE (Tenn.), Susan Collins Susan Margaret CollinsSenate Republicans face tough decision on replacing Ginsburg Democratic senator calls for eliminating filibuster, expanding Supreme Court if GOP fills vacancy What Senate Republicans have said about election-year Supreme Court vacancies MORE (Maine), Cory Gardner Cory Scott GardnerSenate Republicans face tough decision on replacing Ginsburg What Senate Republicans have said about election-year Supreme Court vacancies Chamber of Commerce endorses McSally for reelection MORE (Colo.), Johnny Isakson Johnny IsaksonLoeffler: Trump 'has every right' to fill Ginsburg vacancy before election Bottom line New poll shows tight presidential race in Georgia MORE (Ga.), Lisa Murkowski Lisa Ann MurkowskiSenate Republicans face tough decision on replacing Ginsburg What Senate Republicans have said about election-year Supreme Court vacancies McConnell says Trump nominee to replace Ginsburg will get Senate vote MORE (Alaska) and Mitt Romney Willard (Mitt) Mitt RomneySenate Republicans face tough decision on replacing Ginsburg McConnell says Trump nominee to replace Ginsburg will get Senate vote GOP-led panel to hear from former official who said Burisma was not a factor in US policy MORE (Utah) voted to advance the continuing resolution, which would have fully reopened the government and funded it through Feb. 8.

The measure fell short of the 60 votes needed to break a filibuster.

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The 52-44 vote in support of reopening the government without additional funding for a U.S.-Mexico border wall is a major blow to Trump and Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellObama calls on Senate not to fill Ginsburg's vacancy until after election Planned Parenthood: 'The fate of our rights' depends on Ginsburg replacement Progressive group to spend M in ad campaign on Supreme Court vacancy MORE (R-Ky.).

The Senate also rejected a Trump-backed proposal on Thursday that included $5.7 billion for a border wall. That 50-47 vote also fell short of the 60 needed to advance.

Roughly a quarter of the federal government has been closed since Dec. 22 amid an entrenched fight over funding for a U.S.-Mexico border wall. Approximately 800,000 federal workers have been furloughed or forced to work without pay in the 34 days since the shutdown began. Those workers are poised to miss their second paycheck Friday.

The Democratic proposal would reopen the quarter of the government that has been shuttered and fund it through Feb. 8. It does not include additional funding for the U.S.-Mexico border wall, as demanded by Trump.

Democrats were expected to pick up some GOP defectors on their proposal. Collins and Murkowski both indicated on Wednesday that they would support it, and Gardner's staff told The Denver Post that he would also support the short-term funding bill.

"I voted in favor of the President’s proposed compromise, which would have achieved both goals," Romney said in a statement following the vote. "When that measure failed, I also voted for an alternative proposal that would open the government and give the Democrats two weeks to put up or shut up — come to the table and agree to a final deal on border security and enforcement."

Isakson, speaking from the Senate floor after the votes, said it was time for the Senate to "do some business."

"All Democrats and Republicans pay close attention. I've been here 20 years. I've seen a lot of shutdowns, about five of them. I want to talk about what they produced. The first one under Bill Clinton William (Bill) Jefferson ClintonBarr says Ginsburg 'leaves a towering legacy' Trump reacts to Ginsburg's death: 'An amazing woman who led an amazing life' Jimmy Carter remembers Ruth Bader Ginsburg as 'a beacon of justice' MORE produced Monica Lewinsky, she was an intern in the White House and idle hands are never good," he said.

In a statement following the vote, Alexander said he voted twice to reopen the government, arguing that it was "wrong for either side" to use shutdowns "as a bargaining chip."

“I voted twice today to open the government because it should never have been shut down," he said. "It is always wrong for either side to use shutting down the government as a bargaining chip in budget negotiations — it should be as off-limits as chemical weapons are to warfare."

Alexander has previously backed the Senate taking up a continuing resolution to give lawmakers more time to work out a deal.

“We ought to take the president’s request, immediately consider it … add to it whatever we need to do to get a result, send it to him, sign it and in the meantime open the government up,” Alexander told WREC, a Tennessee radio station, earlier this month.

Alexander acknowledged that the idea of reopening the government for roughly three weeks wouldn’t gain traction without Trump’s support, adding, “I’m hoping the president changes his mind. This is the way you get a result.”

Updated at 4:55 p.m.