Western Australia's Police Commissioner has revealed his son was one of five people injured when a drug lab exploded in Perth.

Karl O'Callaghan told a media conference his 29-year-old son Russell was at a Homeswest unit in Carlisle when there was a blast which tore the roof off.

The power of the blast also sent a fridge smashing through a wall.

The Commissioner said his son received burns to his head, shoulders and arms.

There were four other people also injured in the explosion, including one man who is in a critical condition at Royal Perth Hospital.

Mr O'Callaghan said his son had beaten a drug problem but it appears he may have had a relapse.

"It's very difficult personally, obviously because my son is seriously injured, he's got some very serious burns and I can't see him at the moment" he said.

"He will have to face the consequences of his actions no doubt, but as a father, and as a family member, you know, as a family we're suffering deeply at the moment."

Mr O'Callaghan said his son does not live at the house in Bishopsgate Street but he was visiting the premises.

The Commissioner said he will play no part in the police investigation into the incident.

Complaints

The daughter of former police superintendent Dave Parkinson lives next door to the unit where the explosion happened.

Mr Parkinson says he suspected drug activity was taking place but he was threatened when he tried to confront the occupants.

"They've told my daughter and others that they're going to shoot me with a .22 rifle because I've stood up to them," he said.

His daughter Stacee Parkinson says years of complaints about the tenants have fallen on deaf ears.

The Housing Minister Troy Buswell met her this morning and acknowledged the department's policy of evicting tenants after three complaints needs review.

"I'm disappointed that in this case, and I'm sure in other cases, that the three strikes policy has not delivered the level of protection to the neighbourhood that we had anticipated," he said.