Patients experience formication (derived from the Latin word formica, meaning "ant"), a sensation of insect crawling over or under the skin.

Kupperman scores mainly include hot flashes, sweat, perceptual abnormalities, insomnia, impatience, depression, dizziness, tiredness, fatigue, muscle pain, joint pain, headache, heart palpitation and skin formication , with a total score of 63 points.13 Subjective symptom scores mainly include hot flashes and night sweat (4 points), vulva (2 points), vaginal discomfort (2 points), insomnia (2 points), and other items (1 point).

Intermittent paresthesia, numbness and formication on the fifth finger and ulnar side of the fourth finger are frequent early symptoms.

Patients who use large daily doses of the drug also may report that there are ants or other parasites crawling under their skin (eg, formication , "meth mites") and might present with infected excoriations of their skin as a result of attempting to remove insects.

Symptoms often include formication , pain, numbness, and facial weakness.

It contained the following 13 components: hot flashes (with or without sweating), paresthesia, insomnia (alteration in sleep pattern), nervousness (irritability), melancholia, vertigo, arthralgia and myalgia, headache, palpitation, formication , low sex drive (decreased libido), fatigue, and urinary tract infection.

In addition, high doses of sympathomimetics (which might be the case if stimulants are used non-medically or recreationally) can lead to dry mouth, bruxism, formication , emotional liability, psychosis and seizures.

The original KI consists of questions regarding 11 items, including sweating/hot flashes, palpitation, vertigo, headache, paresthesia, formication , arthralgia, and myalgia (categorized as somatic symptoms), as well as fatigue, nervousness, and melancholia (categorized as psychological symptoms) (11).

The team was unable to determine whether the patient had a headache, nausea, or experienced hallucinations or the feeling of insects crawling on one's skin (i.e., formication ), signs of alcohol withdrawal.