Dolphins at Bills, 1 p.m., CBS

Line: Bills -17 | Total: 40

The Dolphins (0-5) are either the worst team in the N.F.L. or tied for the worst with Cincinnati (0-6). The Bills (4-1) have one of the N.F.L.’s most dominant defenses, and with the rookie running back Devin Singletary expected to return and the ageless Frank Gore always ready to rumble, Buffalo can easily grind out games on the ground. Buffalo’s offense is too conservative to justify a point spread of more than two touchdowns, but the thought of Buffalo losing this game at home is a bit preposterous. Pick: Dolphins +17

Rams at Falcons, 1 p.m. Fox

Line: Rams -3 | Total: 54.5

The training staff of the Rams (3-3) is so talented that Jalen Ramsey’s back injury, which kept him out of the last three games for Jacksonville, suddenly healed the second he was traded to Los Angeles. Ramsey, a terrific and rather dramatic cornerback, got what he wanted, and while he is an upgrade over Marcus Peters — whom the Rams traded to Baltimore — this week will put a spotlight on him: He will be asked to contain Julio Jones of the Falcons (1-5).

The Rams are riding a three-game losing streak, and Jared Goff threw for just 78 yards against San Francisco last week. If Coach Sean McVay wants to make a statement that his team can still put up points in bunches, Atlanta’s defense is the ideal opponent. Pick: Rams -3

Jaguars at Bengals, 1 p.m., CBS

Line: Jaguars -3.5 | Total: 44

With the exception of a blowout loss in Week 1, the Jaguars (2-4) have kept things close each week, playing a lot better football than you’d expect from a team with such a poor record. The Bengals (0-6) have played exactly like a winless team, with days when they look hopeless and others when luck seems to go against them. Now that the Jalen Ramsey drama is behind them, a road win would be a nice ego boost. Pick: Jaguars -3.5

Chargers at Titans, 4:05 p.m., CBS

Line: Titans -2 | Total: 40

It’s reasonable to look at the performance of the Titans (2-4) and think that relative to the overall talent on the team they’ve underperformed with Marcus Mariota at quarterback. Deciding that they have a better shot at winning with Ryan Tannehill at quarterback, however, seems to defy all reason. The Chargers (2-4) are reeling, and it’s no fun to play in Tennessee, but it’s hard to think Coach Mike Vrabel hasn’t made the Titans worse with the move away from Mariota. Pick: Chargers +2