DETROIT  The Police Department here shut down its crime laboratory on Thursday after an audit uncovered serious errors in numerous cases. The audit said sloppy work had probably resulted in wrongful convictions, and officials expect a wave of appeals in cases that the laboratory processed.

The interim mayor, Kenneth V. Cockrel Jr., and the new police chief, James Barren, ordered the laboratory closed; Mr. Cockrel called the audit’s conclusions “shocking and appalling.” Pending and future cases will be sent to the Michigan State Police, which operates seven laboratories.

Officials from the Detroit Police Department, the Wayne County prosecutor’s office and the State Police will try to determine whether the errors resulted in guilty verdicts against innocent people.

“We do not want any of our activities to result in someone being imprisoned that doesn’t belong there,” the Wayne County prosecutor, Kym L. Worthy, said at a news conference with Mr. Cockrel and Mr. Barren. Ms. Worthy said the mistakes also might have let violent criminals remain at large.