A high profile doctor who secured a swing against the Liberal Party in the Coalition's 2011 landslide win will run as an independent in next month's byelection in Wagga Wagga.

The former director of emergency medicine at Wagga Wagga Base Hospital, Joe McGirr, has confirmed he will run, in a move that will put extra pressure on the Liberals to hold the seat.

Independent candidate for Wagga Joe McGirr announces he will run in the September byelection. Credit:Emma Hillier

Although Wagga Wagga has long been a safe Liberal seat, senior party sources have said that Premier, Gladys Berejiklian, is worried about a voter backlash after the Daryl Maguire scandal.

Snow Valleys councillor Julia Ham has been preselected for the Liberals. It is understood Ms Berejiklian made it clear she wanted a woman for the seat.