There are a few things I love about this play design. First, the Eagles caught the Bills in their nickel package by lining up in 21 personnel (two backs and one tight end). The Eagles lined up in this look last week against Dallas (with both Sanders and Jordan Howard on the field) three times, and threw it twice. They lined up once earlier in the game, as you can see in the clip above, and actually threw it that time as well. The trick of having two halfbacks in the game at once is to make teams respect the run. Sanders' touchdown will go a long way toward doing just that.

This is a simple "lead" play from the split gun formation. Quarterback Carson Wentz is in the shotgun with the backs flanking him on each side. Howard releases immediately up to the second level and blocks the playside linebacker. Center Jason Kelce blocks the backside linebacker. The other four offensive linemen account for the four defensive linemen one-on-one. This leaves the down safety, who has to respect Wentz's ability to keep the football. All of this across the board allows this play to hit. When Sanders reaches the third level of the defense, he lays on the gas and explodes to the end zone for the longest play of the season for the Eagles' offense.

As Pederson alluded to after the game, the Eagles actually ran the same play earlier in the game. It was a Run Pass Option where Wentz saw a matchup on the perimeter pre-snap with Bills cornerback Tre' Davious White (5-11) against wide receiver Alshon Jeffery (6-2) in press coverage. Wentz decided to attack downfield instead in the low post, but the pass fell incomplete.

The trick of two-back sets when you have two ballcarriers in the game is to try and get teams to respect the run. Most often, teams in these sets are trying to create favorable matchups in the passing game. The Eagles hit tight end Dallas Goedert for a touchdown last week against the Cowboys after he was matched up with a linebacker. Just like in 12 personnel (two tight ends), however, balance is crucial to prevent it from being predictable. The Eagles showed this week that they can create big plays from 21 personnel as well as they do from their 12 personnel set.