WASHINGTON — Secretary of State Mike Pompeo used his first major policy address to deliver a hard-line speech on Monday, in which he demanded that Iran change just about everything regarding its behavior on the world stage.

He insisted that Iran end all nuclear enrichment programs and close its heavy water reactor, saying it did not have the right to such a program. He also appealed directly to the Iranian people, suggesting they should reject the clerical government in Tehran, the capital.

“What has the Iranian revolution given to the Iranian people?” Mr. Pompeo asked at one point, and then offered an answer: “The hard grip of repression is all that millions of Iranians have ever known.”

Iran’s right to enrich uranium, as a signatory to the Nuclear Nonproliferation Treaty, is debatable. More than a dozen countries in the world enrich uranium, with several doing so solely for civilian purposes, such as energy generation and medical uses.