SAN FRANCISCO — Uber laid off 350 employees on Monday, in the latest indication that the ride-hailing company is trying to respond to concerns among investors that it is losing too much money.

The cuts, the third round in recent months, were focused in the autonomous vehicle unit, operations, recruiting and customer support, an Uber spokesman said. Since July, the company has cut more than 1,000 jobs, more than 2 percent of its work force.

Shares of Uber began trading on Wall Street in May, in one of the most anticipated initial public offerings in recent years. But the stock’s performance has been disappointing, with its price down about 30 percent since the first day of trading.

Investors reacted favorably to the layoffs on Monday, sending Uber’s share price up 4 percent in afternoon trading.