Two Brisbane teenagers have been charged after allegedly killing a possum by repeatedly running over it with a car.

Two 17-year-old men allegedly posted a video of the alleged event to the photo and video sharing app Snapchat, which showed a possum being repeatedly run over by a car and then attempting to flee, with its entrails exposed.

The video showed a possum getting repeatedly run over by a car. Credit:Snapchat

The video was sent into RSPCA from an anonymous woman on Monday January 11.

RSPCA Queensland inspectors charged Callum Gibson McKenzie, 17, and Hunter Lawrence Jonasen, 17, with serious animal cruelty on Friday, a charge that carries a maximum penalty of seven years imprisonment.