Democratic front-runner Hillary Clinton lost her chances of becoming president after alienating two key states, anti-tax crusader Grover Norquist said Monday.

"Under her new rules, fracking would exist almost nowhere," the president and founder of Americans for Tax Reform told CNBC's "Squawk on the Street." "Democrats used to be able to insult the energy industry because they lived in Texas, Oklahoma, Louisiana and Alaska [and] they don't vote Democrat. But she declared war on Pennsylvania and Ohio with that statement. That's not the way to win the election."

Clinton said in a debate Sunday in Flint, Michigan, she does not support fracking.

The Marcellus shale formation stretches underground across Pennsylvania and into several other states. The advent of hydraulic fracking set off a natural gas boom starting in 2008 in those states.

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Norquist also said Clinton took herself out of contention with her comment on guns, alienating a "bloc of the electorate that didn't exist 20 years ago."