Russia has rebuffed claims that its warplanes struck a hospital supported by Doctors Without Borders in northern Syria in airstrikes the previous day that killed at least nine as Syrian government forces and a predominantly Kurdish coalition made gains against rivals in the country's north.

In Moscow, President Vladimir Putin's spokesman Dmitry Peskov told reporters the hospital report was another case in which those who make accusations against Russia cannot back them up.

The Britain-based Syrian Observatory for Human Rights had said Russian warplanes targeted the hospital in Idlib province on Monday, destroying it and killing nine people.

The makeshift clinic was supported by the international aid group, also known by its French acronym MSF. France said that such attacks “could constitute war crimes.”

Peskov, in a conference call with journalists, said those who make such accusations should instead do as Moscow does and rely on the “primary source” - official announcements from the Syrian government. When pressed, he told journalists the Syrian government had made a string of announcement on who could have been behind the bombing. He also noted that Syria's ambassador to Russia said the hospital was destroyed by the Americans.

“We categorically reject such claims, even more so because each time those who make such claims prove unable somehow to corroborate their unsubstantiated accusations,” Peskov said.

MSF said the hospital in the town of Maaret al-Numan in Idlib province was hit four times in attacks that were minutes apart. The attack left the local population of around 40,000 without access to medical services, said MSF mission chief Massimiliano Rebaudengo.

The Observatory said and other opposition activists said another hospital in Maaret al-Numan was also hit Monday, most likely by a Syrian government airstrike.

And in the neighboring Aleppo province, a missile struck a children's hospital in the town of Azaz, killing five people, including three children and a pregnant woman, according to the Observatory. A third air raid hit a school in a nearby village, killing seven and wounding others.

Opposition official Abdulrahman Al-Hassan said the women's hospital in Azaz was hit by two surface-to-surface missiles, blaming the attack on Russia because “photos of the missiles have Russian language (and) because we haven't seen this kind (of missile) before the Russian intervention.”

In pictures: Russian air strikes in Syria Show all 19 1 /19 In pictures: Russian air strikes in Syria In pictures: Russian air strikes in Syria Syrian boys cry following Russian air strikes on the rebel-held Fardous neighbourhood of the northern embattled Syrian city of Aleppo Getty In pictures: Russian air strikes in Syria Russian defense ministry spokesman Major General Igor Konashenkov speaks to the media in Moscow, Russia. Konashenkov strongly warned the United States against striking Syrian government forces and issued a thinly-veiled threat to use Russian air defense assets to protect them AP In pictures: Russian air strikes in Syria Syrians wait to receive treatment at a hospital following Russian air strikes on the rebel-held Fardous neighbourhood of the northern embattled Syrian city of Alepp Getty In pictures: Russian air strikes in Syria Russian Deputy Defense Minister Anatoly Antonov speaks at a briefing in the Defense Ministry in Moscow, Russia. Antonov said the Russian air strikes in Syria have killed about 35,000 militants, including about 2,700 residents of Russia AP In pictures: Russian air strikes in Syria Jameel Mustafa Habboush, receives oxygen from civil defence volunteers, known as the white helmets, as they rescue him from under the rubble of a building following Russian air strikes on the rebel-held Fardous neighbourhood of the northern embattled Syrian city of Aleppo Getty In pictures: Russian air strikes in Syria Civil defence members rest amidst rubble in a site hit by what activists said were airstrikes carried out by the Russian air force in the town of Douma, eastern Ghouta in Damascus, Syria Reuters In pictures: Russian air strikes in Syria A girl carrying a baby inspects damage in a site hit by what activists said were airstrikes carried out by the Russian air force in the town of Douma, eastern Ghouta in Damascus, Syria Reuters In pictures: Russian air strikes in Syria Civilians and civil defence members look for survivors at a site damaged after Russian air strikes on the Syrian rebel-held city of Idlib, Syria Reuters In pictures: Russian air strikes in Syria Civilians and civil defence members carry an injured woman on a stretcher at a site damaged after Russian air strikes on the Syrian rebel-held city of Idlib, Syria Reuters In pictures: Russian air strikes in Syria Volunteers from Syria Civil Defence, also known as the White Helmets, help civilians after Russia carried out its first airstrikes in Syria In pictures: Russian air strikes in Syria The aftermath of Russian airstrike in Talbiseh, Syria In pictures: Russian air strikes in Syria Smoke billows from buildings in Talbiseh, in Homs province, western Syria, after airstrikes by Russian warplanes AP In pictures: Russian air strikes in Syria Russian Air Forces carry out an air strike in the ISIS controlled Al-Raqqah Governorate. Russia's KAB-500s bombs completely destroy the Liwa al-Haqq command unit In pictures: Russian air strikes in Syria Caspian Flotilla of the Russian Navy firing Kalibr cruise missiles against remote Isis targets in Syria Â© TASS/ITAR-TASS Photo/Corbis In pictures: Russian air strikes in Syria Russia claimed it hit eight Isis targets, including a "terrorist HQ and co-ordination centre" that was completely destroyed In pictures: Russian air strikes in Syria A video grab taken from the footage made available on the Russian Defence Ministry's official website, purporting to show an airstrike in Syria In pictures: Russian air strikes in Syria A release from the Russian defence ministry purportedly showing targets in Syria being hit In pictures: Russian air strikes in Syria Russia launched air strikes in war-torn Syria, its first military engagement outside the former Soviet Union since the occupation of Afghanistan in 1979. Russian warplanes carried out strikes in three Syrian provinces along with regime aircraft as Putin seeks to steal US President Barack Obama's thunder by pushing a rival plan to defeat Isis militants in Syria In pictures: Russian air strikes in Syria Caspian Flotilla of the Russian Navy firing Kalibr cruise missiles against remote Isis targets in Syria, a thousand kilometres away. The targets include ammunition factories, ammunition and fuel depots, command centres, and training camps Â© TASS/ITAR-TASS Photo/Corbis

The airstrikes came just days after Russia and other world powers agreed to bring about a pause in fighting that would allow for the delivery of humanitarian aid and the revival of Syrian peace talks. The projected truce agreed on Friday in Munich was to begin in a week, but there has been no sign it would happen.

Meanwhile, Syrian government troops and a predominantly Kurdish coalition of fighters advanced and captured more areas in the north from rival groups on Tuesday, while pro-government forces routed extremists from a main power station in the area.

The north has been the focus of the most intense clashes in recent weeks in Syria.

Syria's state news agency SANA and the Observatory said government forces took the villages of Ahras and Misqan in the northern province of Aleppo. Separately, members of the Syria Democratic Forces, a coalition of Arab and Kurdish groups, captured the major town of Tel Rifaat, one of the largest militant strongholds in Aleppo.After Tel Rifaat, SDF fighters also took the nearby village of Kfar Naseh, south of the town.

The SDF fighters are a separate entity in Syria's five-year civil war and have mostly battled the Islamic State group. Parts of the coalition oppose President Bashar Assad but have also fought against other rebels and the Western-backed opposition.

Intense clashes broke out Tuesday near the village of Kaljibrin as SDF fighters tried to reach it, according to the Observatory and Aleppo-based activist Bahaa al-Halaby. If SDF captures Kaljibrin, it would squeeze rebels in their stronghold of Mareh and the adjacent village of Sheikh Issa, which is also under attack by the IS.

Also Tuesday, government forces and allied gunmen captured a power station in eastern Aleppo from IS that the extremists had used as a jailhouse. The Observatory said the station and nearby villages were captured under the cover of aerial attacks by Syrian and Russian warplanes and helicopter gunships.

Meanwhile, in the city of Aleppo, insurgents repelled an attack by SDF fighters on the neighborhoods of Hullok and Bustan al-Basha, according to al-Halaby and the Aleppo Media Center.

“They were trying to besiege (rebel-held parts) of the city of Aleppo but were forced out,” al-Halaby said via Skype.

In Damascus, the U.N. special envoy to Syria, Staffan de Mistura, met on Tuesday with Foreign Minister Walid al-Moallem. In a brief statement to reporters after the meeting, de Mistura said the talks focused on “the issue of humanitarian and hindered access to all besieged areas, not only by the government but also by the opposition and ISIL,” another acronym that refers to the IS.

The UN envoy arrived in the Syrian capital Monday for discussions on aid deliveries and how to resume peace talks in Geneva.

Indirect peace talks between representatives of the Syrian government and the opposition collapsed earlier this month in Geneva after just two days, largely because of the government offensive in Aleppo.

Berry reported from Moscow. Associated Press writer Albert Aji contributed to this report from Damascus, Syria.