American College of Sports Medicine (2009) American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 41:687–708. doi:10.1249/MSS.0b013e3181915670

Atherton PJ, Phillips BE, Wilkinson DJ (2015) Exercise and regulation of protein metabolism. Prog Mol Biol Transl Sci 135:75–98. doi:10.1016/bs.pmbts.2015.06.015

Barbieri E, Sestili P (2012) Reactive oxygen species in skeletal muscle signaling. J Signal Transduct 2012:982794

Barcelos LC, Nunes PRP, de Souza LRMF et al (2015) Low-load resistance training promotes muscular adaptation regardless of vascular occlusion, load, or volume. Eur J Appl Physiol 115:1559–1568. doi:10.1007/s00421-015-3141-9

Bar-Peled L, Sabatini DM (2014) Regulation of mTORC1 by amino acids. Trends Cell Biol 24:400–406. doi:10.1016/j.tcb.2014.03.003

Beck GR (2003) Inorganic phosphate as a signaling molecule in osteoblast differentiation. J Cell Biochem 90:234–243. doi:10.1002/jcb.10622

Bergquist AJ, Wiest MJ, Collins DF (2012) Motor unit recruitment when neuromuscular electrical stimulation is applied over a nerve trunk compared with a muscle belly: quadriceps femoris. J Appl Physiol Bethesda Md 1985 113:78–89. doi:10.1152/japplphysiol.00074.2011

Bigland-Ritchie B, Cafarelli E, Vøllestad NK (1986) Fatigue of submaximal static contractions. Acta Physiol Scand Suppl 556:137–148

Bodine SC, Stitt TN, Gonzalez M et al (2001) Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3:1014–1019. doi:10.1038/ncb1101-1014

Chin ER (2005) Role of Ca2+/calmodulin-dependent kinases in skeletal muscle plasticity. J Appl Physiol Bethesda Md 1985 99:414–423. doi:10.1152/japplphysiol.00015.2005

Collins DF (2007) Central contributions to contractions evoked by tetanic neuromuscular electrical stimulation. Exerc Sport Sci Rev 35:102–109. doi:10.1097/jes.0b013e3180a0321b

Counts BR, Buckner SL, Dankel SJ et al (2016) The acute and chronic effects of “NO LOAD” resistance training. Physiol Behav 164:345–352. doi:10.1016/j.physbeh.2016.06.024

Dankel SJ, Buckner SL, Jessee MB et al (2016a) Post-exercise blood flow restriction attenuates muscle hypertrophy. Eur J Appl Physiol 116:1955–1963. doi:10.1007/s00421-016-3447-2

Dankel SJ, Jessee MB, Abe T, Loenneke JP (2016b) The effects of blood flow restriction on upper-body musculature located distal and proximal to applied pressure. Sports Med Auckl NZ 46:23–33. doi:10.1007/s40279-015-0407-7

Dankel SJ, Buckner SL, Jessee MB et al (2017a) Can blood flow restriction augment muscle activation during high-load training? Clin Physiol Funct Imaging. doi:10.1111/cpf.12414

Dankel SJ, Counts BR, Barnett BE et al (2017b) Muscle adaptations following 21 consecutive days of strength test familiarization compared with traditional training. Muscle Nerve. doi:10.1002/mus.25488

De Luca CJ, Erim Z (1994) Common drive of motor units in regulation of muscle force. Trends Neurosci 17:299–305

De Luca CJ, LeFever RS, McCue MP, Xenakis AP (1982) Control scheme governing concurrently active human motor units during voluntary contractions. J Physiol 329:129–142

Debold EP (2012) Recent insights into the molecular basis of muscular fatigue. Med Sci Sports Exerc 44:1440–1452. doi:10.1249/MSS.0b013e31824cfd26

Dentel JN, Blanchard SG, Ankrapp DP et al (2005) Inhibition of cross-bridge formation has no effect on contraction-associated phosphorylation of p38 MAPK in mouse skeletal muscle. Am J Physiol Cell Physiol 288:C824–C830. doi:10.1152/ajpcell.00500.2004

Ellefsen S, Hammarström D, Strand TA et al (2015) Blood flow-restricted strength training displays high functional and biological efficacy in women: a within-subject comparison with high-load strength training. Am J Physiol Regul Integr Comp Physiol 309:R767–R779. doi:10.1152/ajpregu.00497.2014

Fahs CA, Loenneke JP, Thiebaud RS et al (2015) Muscular adaptations to fatiguing exercise with and without blood flow restriction. Clin Physiol Funct Imaging 35:167–176. doi:10.1111/cpf.12141

Farup J, de Paoli F, Bjerg K et al (2015) Blood flow restricted and traditional resistance training performed to fatigue produce equal muscle hypertrophy. Scand J Med Sci Sports 25:754–763. doi:10.1111/sms.12396

Fry CS, Glynn EL, Drummond MJ et al (2010) Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. J Appl Physiol Bethesda Md 1985 108:1199–1209. doi:10.1152/japplphysiol.01266.2009

Garten RS, Goldfarb A, Crabb B, Waller J (2015) The impact of partial vascular occlusion on oxidative stress markers during resistance exercise. Int J Sports Med 36:542–549. doi:10.1055/s-0034-1396827

Goldfarb AH, Garten RS, Chee PDM et al (2008) Resistance exercise effects on blood glutathione status and plasma protein carbonyls: influence of partial vascular occlusion. Eur J Appl Physiol 104:813–819. doi:10.1007/s00421-008-0836-1

Goldmann WH (2012) Mechanotransduction and focal adhesions. Cell Biol Int 36:649–652. doi:10.1042/CBI20120184

Gorgey AS, Timmons MK, Dolbow DR et al (2016) Electrical stimulation and blood flow restriction increase wrist extensor cross-sectional area and flow meditated dilatation following spinal cord injury. Eur J Appl Physiol 116:1231–1244. doi:10.1007/s00421-016-3385-z

Goto K, Ishii N, Kizuka T, Takamatsu K (2005) The impact of metabolic stress on hormonal responses and muscular adaptations. Med Sci Sports Exerc 37:955–963

Gundermann DM, Walker DK, Reidy PT et al (2014) Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin. Am J Physiol Endocrinol Metab 306:E1198–1204. doi:10.1152/ajpendo.00600.2013

Hausenblas HA, Fallon EA (2006) Exercise and body image: a meta-analysis. Psychol Health 21:33–47. doi:10.1080/14768320500105270

Hornberger TA, Chu WK, Mak YW et al (2006) The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle. Proc Natl Acad Sci USA 103:4741–4746. doi:10.1073/pnas.0600678103

Ikai M, Fukunaga T (1970) A study on training effect on strength per unit cross-sectional area of muscle by means of ultrasonic measurement. Int Z Für Angew Physiol Einschl Arbeitsphysiol 28:173–180. doi:10.1007/BF00696025

Ito N, Ruegg UT, Kudo A et al (2013) Activation of calcium signaling through Trpv1 by nNOS and peroxynitrite as a key trigger of skeletal muscle hypertrophy. Nat Med 19:101–106. doi:10.1038/nm.3019

Jacobs BL, McNally RM, Kim KJ et al (2017) Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling. J Biol Chem. doi:10.1074/jbc.M117.777805

Kraemer WJ, Noble BJ, Clark MJ, Culver BW (1987) Physiologic responses to heavy-resistance exercise with very short rest periods. Int J Sports Med 8:247–252. doi:10.1055/s-2008-1025663

Laurentino G, Ugrinowitsch C, Aihara AY et al (2008) Effects of strength training and vascular occlusion. Int J Sports Med 29:664–667. doi:10.1055/s-2007-989405

Laurentino GC, Ugrinowitsch C, Roschel H et al (2012) Strength training with blood flow restriction diminishes myostatin gene expression. Med Sci Sports Exerc 44:406–412. doi:10.1249/MSS.0b013e318233b4bc

Laurin J, Pertici V, Dousset E et al (2015) Group III and IV muscle afferents: role on central motor drive and clinical implications. Neuroscience 290:543–551. doi:10.1016/j.neuroscience.2015.01.065

Lauver JD, Cayot TE, Rotarius T, Scheuermann BW (2017) The effect of eccentric exercise with blood flow restriction on neuromuscular activation, microvascular oxygenation, and the repeated bout effect. Eur J Appl Physiol. doi:10.1007/s00421-017-3589-x

LeFever RS, De Luca CJ (1982) A procedure for decomposing the myoelectric signal into its constituent action potentials–part I: technique, theory, and implementation. IEEE Trans Biomed Eng 29:149–157

Lin H, Wang SW, Wang RY, Wang PS (2001) Stimulatory effect of lactate on testosterone production by rat leydig cells. J Cell Biochem 83:147–154

Loenneke JP, Fahs CA, Wilson JM, Bemben MG (2011) Blood flow restriction: the metabolite/volume threshold theory. Med Hypotheses 77:748–752. doi:10.1016/j.mehy.2011.07.029

Loenneke JP, Balapur A, Thrower AD et al (2012a) Blood flow restriction reduces time to muscular failure. Eur J Sport Sci 12:238–243. doi:10.1080/17461391.2010.551420

Loenneke JP, Wilson JM, Marín PJ et al (2012b) Low intensity blood flow restriction training: a meta-analysis. Eur J Appl Physiol 112:1849–1859. doi:10.1007/s00421-011-2167-x

Manini TM, Clark BC (2009) Blood flow restricted exercise and skeletal muscle health. Exerc Sport Sci Rev 37:78–85. doi:10.1097/JES.0b013e31819c2e5c

Marcotte GR, West DWD, Baar K (2015) The molecular basis for load-induced skeletal muscle hypertrophy. Calcif Tissue Int 96:196–210. doi:10.1007/s00223-014-9925-9

Meyer RA (2006) Does blood flow restriction enhance hypertrophic signaling in skeletal muscle? J Appl Physiol Bethesda Md 1985 100:1443–1444. doi:10.1152/japplphysiol.01636.2005

Mitchell CJ, Churchward-Venne TA, West DWD et al (2012) Resistance exercise load does not determine training-mediated hypertrophic gains in young men. J Appl Physiol 113:71. doi:10.1152/japplphysiol.00307.2012

Moritani T, Sherman WM, Shibata M et al (1992) Oxygen availability and motor unit activity in humans. Eur J Appl Physiol 64:552–556

Morton RW, Oikawa SY, Wavell CG et al (2016) Neither load nor systemic hormones determine resistance training-mediated hypertrophy or strength gains in resistance-trained young men. J Appl Physiol Bethesda Md 1985 121:129–138. doi:10.1152/japplphysiol.00154.2016

Nalbandian M, Takeda M (2016) Lactate as a signaling molecule that regulates exercise-induced adaptations. Biology 5:38

Natsume T, Ozaki H, Saito AI et al (2015) Effects of electrostimulation with blood flow restriction on muscle size and strength. Med Sci Sports Exerc 47:2621–2627. doi:10.1249/MSS.0000000000000722

Nielsen JL, Aagaard P, Bech RD et al (2012) Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood flow restriction. J Physiol 590:4351–4361. doi:10.1113/jphysiol.2012.237008

Nishimura A, Sugita M, Kato K et al (2010) Hypoxia increases muscle hypertrophy induced by resistance training. Int J Sports Physiol Perform 5:497–508

O’Neil TK, Duffy LR, Frey JW, Hornberger TA (2009) The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions. J Physiol 587:3691–3701. doi:10.1113/jphysiol.2009.173609

Ogasawara R, Loenneke JP, Thiebaud RS, Abe T (2013) Low-load bench press training to fatigue results in muscle hypertrophy similar to high-load bench press training. Int J Clin Med 4:114. doi:10.4236/ijcm.2013.42022

Oishi Y, Tsukamoto H, Yokokawa T et al (2015) Mixed lactate and caffeine compound increases satellite cell activity and anabolic signals for muscle hypertrophy. J Appl Physiol Bethesda Md 1985 118:742–749. doi:10.1152/japplphysiol.00054.2014

Ozaki H, Abe T, Mikesky AE et al (2015) Physiological stimuli necessary for muscle hypertrophy. J Phys Fit Sports Med 4:43–51

Ozaki H, Loenneke JP, Buckner SL, Abe T (2016) Muscle growth across a variety of exercise modalities and intensities: contributions of mechanical and metabolic stimuli. Med Hypotheses 88:22–26. doi:10.1016/j.mehy.2015.12.026

Park JH, Brown RL, Park CR et al (1987) Functional pools of oxidative and glycolytic fibers in human muscle observed by 31P magnetic resonance spectroscopy during exercise. Proc Natl Acad Sci USA 84:8976–8980

Pearson SJ, Hussain SR (2015) A review on the mechanisms of blood-flow restriction resistance training-induced muscle hypertrophy. Sports Med Auckl NZ 45:187–200. doi:10.1007/s40279-014-0264-9

Person RS (1974) Rhythmic activity of a group of human motoneurones during voluntary contraction of a muscle. Electroencephalogr Clin Neurophysiol 36:585–595. doi:10.1016/0013-4694(74)90225-9

Schoenfeld BJ (2013) Potential mechanisms for a role of metabolic stress in hypertrophic adaptations to resistance training. Sports Med 43:179–194. doi:10.1007/s40279-013-0017-1

Schott J, McCully K, Rutherford OM (1995) The role of metabolites in strength training. II. Short versus long isometric contractions. Eur J Appl Physiol 71:337–341

Smith RC, Rutherford OM (1995) The role of metabolites in strength training. I. A comparison of eccentric and concentric contractions. Eur J Appl Physiol 71:332–336

Spina A, Sorvillo L, Esposito A et al (2013) Inorganic phosphate as a signaling molecule: a potential strategy in osteosarcoma treatment. Curr Pharm Des 19:5394–5403

Suga T, Okita K, Morita N et al (2009) Intramuscular metabolism during low-intensity resistance exercise with blood flow restriction. J Appl Physiol Bethesda Md 1985 106:1119–1124. doi:10.1152/japplphysiol.90368.2008

Suga T, Okita K, Morita N et al (2010) Dose effect on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction. J Appl Physiol Bethesda Md 1985 108:1563–1567. doi:10.1152/japplphysiol.00504.2009

Suga T, Okita K, Takada S et al (2012) Effect of multiple set on intramuscular metabolic stress during low-intensity resistance exercise with blood flow restriction. Eur J Appl Physiol 112:3915–3920. doi:10.1007/s00421-012-2377-x

Takano H, Morita T, Iida H et al (2005) Hemodynamic and hormonal responses to a short-term low-intensity resistance exercise with the reduction of muscle blood flow. Eur J Appl Physiol 95:65–73. doi:10.1007/s00421-005-1389-1

Takarada Y, Nakamura Y, Aruga S et al (2000a) Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion. J Appl Physiol Bethesda Md 1985 88:61–65

Takarada Y, Takazawa H, Sato Y et al (2000b) Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans. J Appl Physiol 88:2097–2106

Tanimoto M, Sanada K, Yamamoto K et al (2008) Effects of whole-body low-intensity resistance training with slow movement and tonic force generation on muscular size and strength in young men. J Strength Cond Res 22:1926–1938. doi:10.1519/JSC.0b013e318185f2b0

Timmerman KL, Lee JL, Dreyer HC et al (2010) Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab 95:3848–3857. doi:10.1210/jc.2009-2696

Vandenborne K, McCully K, Kakihira H et al (1991) Metabolic heterogeneity in human calf muscle during maximal exercise. Proc Natl Acad Sci 88:5714–5718. doi:10.1073/pnas.88.13.5714

Villanueva MG, Lane CJ, Schroeder ET (2015) Short rest interval lengths between sets optimally enhance body composition and performance with 8 weeks of strength resistance training in older men. Eur J Appl Physiol 115:295–308. doi:10.1007/s00421-014-3014-7

Wernbom M, Järrebring R, Andreasson MA, Augustsson J (2009) Acute effects of blood flow restriction on muscle activity and endurance during fatiguing dynamic knee extensions at low load. J Strength Cond Res 23:2389–2395. doi:10.1519/JSC.0b013e3181bc1c2a

West DWD, Baar K (2013) May the Force move you: TSC-ing the mechanical activation of mTOR. J Physiol 591:4369–4370. doi:10.1113/jphysiol.2013.260216

West DWD, Burd NA, Tang JE et al (2010) Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors. J Appl Physiol Bethesda Md 1985 108:60–67. doi:10.1152/japplphysiol.01147.2009

Westgaard RH, de Luca CJ (1999) Motor unit substitution in long-duration contractions of the human trapezius muscle. J Neurophysiol 82:501–504

Willkomm L, Schubert S, Jung R et al (2014) Lactate regulates myogenesis in C2C12 myoblasts in vitro. Stem Cell Res 12:742–753. doi:10.1016/j.scr.2014.03.004

Wolfe RR (2006) The underappreciated role of muscle in health and disease. Am J Clin Nutr 84:475–482

Yasuda T, Brechue WF, Fujita T et al (2009) Muscle activation during low-intensity muscle contractions with restricted blood flow. J Sports Sci 27:479–489. doi:10.1080/02640410802626567