Republicans in Washington are dead set against Judge Roy Moore Roy Stewart MooreVulnerable Senate Democrat urges unity: 'Not about what side of the aisle we're on' Sessions hits back at Trump days ahead of Alabama Senate runoff Judge allows Roy Moore lawsuit over Sacha Baron Cohen prank to proceed MORE being the party’s Senate nominee in Alabama next year and say they will do whatever is possible to prevent that from happening.

Moore is expected to announce a decision soon on whether to challenge Sen. Doug Jones (D-Ala.), a top Republican target, and a new poll shows him leading a field of possible GOP Senate candidates.

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Moore, 72, lost to Jones in a 2017 special election after several women accused him of making sexual advances on them when they were teenagers and he was in his 30s.

Senate GOP officials say it would be a disaster if Moore is the party’s nominee.

“It would be the top priority, making sure he didn’t win the primary,” said a Senate Republican strategist. “I don’t think it’s going to happen.”

A Mason-Dixon poll released Tuesday showed Moore leading a field of potential Republican candidates, with 27 percent support among registered Republicans.

The runner up, former Rep. Mo Brooks Morris (Mo) Jackson BrooksOvernight Defense: Trump hosts Israel, UAE, Bahrain for historic signing l Air Force reveals it secretly built and flew new fighter jet l Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' OVERNIGHT ENERGY: House Democrats tee up vote on climate-focused energy bill next week | EPA reappoints controversial leader to air quality advisory committee | Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals,' official says MORE (R-Ala.), garnered 18 percent, while Rep. Bradley Byrne Bradley Roberts ByrneBottom line Jerry Carl wins GOP Alabama runoff to replace Rep. Bradley Byrne Jeff Sessions loses comeback bid in Alabama runoff MORE (R-Ala.) tallied 13 percent.

The GOP strategist questioned the significance of the poll, arguing “it’s way too early.”

A second Senate GOP strategist said “if Roy Moore wins the nomination, Republicans lose the seat. Full stop.”

“There’s no way on earth Roy Moore can be handed the nomination so he can turn around and give the seat back to Democrats. This is a seat that belongs in the hands of Alabama Republicans, not Democrats,” the strategist added.

The strategist said Senate Majority Leader Mitch McConnell (R-Ky.) is in step with the National Republican Senatorial Committee and “every single Republican in the Senate who is interested in passing legislation or stopping legislation in the Senate.”

McConnell called on Moore to “step aside” in 2017 after stories about him pursuing teenage girls surfaced. “I believe the women,” McConnell said at the time.

Bill Armistead, Moore’s 2017 campaign chairman, declined to comment on opposition from Senate Republicans to Moore’s 2020 candidacy.

Moore told Republican activists this past weekend that he would announce his decision on a Senate run in the next several weeks.

Moore said in an interview on American Family Radio last month that he is “seriously considering it” and said the 2017 Senate race was “stolen.”

If Moore does run, it’s an open question whether President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE would back him.

Trump endorsed Moore in the 2017 special election when other Republicans were calling on Moore to withdraw.

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“The most influential person in the primary down there would be Donald Trump because everybody saw what his endorsement did for Ron DeSantis Ron DeSantisFlorida attorney general scrutinizing Bloomberg paying fines for felons to vote Trump may meet with potential Supreme Court pick in Miami Florida governor unveils legislation targeting protesters in 'violent or disorderly' demonstrations MORE, so that might be the most important thing,” said Jim McLaughlin, a Republican pollster who has done work in Alabama. Florida Gov. Ron DeSantis cruised to victory in the 2018 gubernatorial race's Republican primary on the back of Trump’s endorsement.

Trump followed McConnell’s lead during the 2017 special election primary by endorsing the GOP incumbent, former Sen. Luther Strange Luther Johnson StrangeSessions hits back at Trump days ahead of Alabama Senate runoff The biggest political upsets of the decade State 'certificate of need' laws need to go MORE (R-Ala.), but the move backfired when Moore won a stunning upset. It was one of the few times when Trump was out of step with Republican primary voters.

If Trump endorsed Moore, it could pave his path to victory in the primary, if not the general election.

Moore would have to win a majority of the vote in the March 3, 2020, primary to avoid a runoff election in April.

McLaughlin says Trump is unlikely to back Moore in a primary after he lost what Republicans initially thought would be a sure-fire GOP win in the 2017 special election for former Sen. Jeff Sessions Jefferson (Jeff) Beauregard SessionsGOP set to release controversial Biden report Trump's policies on refugees are as simple as ABCs Ocasio-Cortez, Velázquez call for convention to decide Puerto Rico status MORE’s (R-Ala.) seat.

“I think after everything that happened, I don’t see the White House being big fans of Roy Moore right now,” he said.

Senate Republicans control 53 seats but the 2020 electoral map favors Democrats. GOP candidates will have to defend 22 seats — including in Colorado and Maine, which voted for Democratic presidential nominee Hillary Clinton Hillary Diane Rodham ClintonDemocratic groups using Bloomberg money to launch M in Spanish language ads in Florida The Hill's Campaign Report: Presidential polls tighten weeks out from Election Day More than 50 Latino faith leaders endorse Biden MORE in 2016.

Senate Democratic Leader Charles Schumer Chuck SchumerCruz blocks amended resolution honoring Ginsburg over language about her dying wish Senate Democrats introduce legislation to probe politicization of pandemic response Schumer interrupted during live briefing by heckler: 'Stop lying to the people' MORE (N.Y.) needs to pick up four seats — or three seats and Democratic control of the White House — to become majority leader. That task becomes harder if Jones loses his reelection, something many in Washington consider likely unless he runs against a particularly weak Republican candidate.

Jones, a former U.S. attorney, became the first Democrat to win a Senate race in Alabama in 25 years by beating Moore handily among women and college educated voters — two demographics that McConnell has identified as key targets in 2020.

Jones outperformed Moore by 16 points among female voters and 11 points among college graduates, according to exit polling.

McConnell told reporters last week that his priority going into 2020 is to improve the performance of GOP candidates among women and college-educated voters.

McConnell believes Republicans lost key Senate and House races in 2018 because “we got crushed in the suburbs.”

“We lost college graduates and women in the suburbs, which led in the House to loses in suburban Kansas City, Oklahoma City, Houston, Dallas, Atlanta, Charleston, South Carolina,” he told a small group of reporters last week. “We’re determined not to lose women, certainly not by 19 points, and college graduates in our Senate races and I don’t think we will."

A Moore candidacy in Alabama could also hurt Republicans running in other states, as Democrats would seek to link Moore and his problems to his potential GOP colleagues.

Washington Republicans, however, must be careful in how they tackle Moore.

He used their support for Strange in 2017 against the incumbent senator by ramping up his assault on the GOP establishment. It was an effective tactic at a time when many Republican primary voters were bitterly disappointed by the party’s failure to repeal the Affordable Care Act in the summer of that year.

Moore attacked Strange in their final debate for being the beneficiary of ads funded by the Senate Leadership Fund, a super PAC linked to McConnell.

Moore lashed out against what he called the “scurrilous, false and deceiving ads” funded out of Washington by “a Super PAC designed to keep people there they want to keep there.”