Neither bomb got close to its intended target, and neither contained a written message, according to law enforcement officials, but the twin discoveries led to other undetonated devices being found elsewhere, including in the mailroom at CNN’s New York headquarters and a district office of Rep. Debbie Wasserman Schultz (D-Fla.).

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James P. O’Neill, commissioner of the New York Police Department, said police found what “appeared to be a live explosive device” at CNN addressed to former Obama administration CIA director John Brennan, though officials did not immediately say how effective that or the other devices might have been at causing damage.

As more devices were discovered, a disturbing pattern emerged — the bomber or bombers appeared to be targeting prominent figures on the political left.

The first such package was discovered Monday at the New York home of George Soros, a billionaire activist known to fund pro-democracy and liberal political groups.

Officials described the devices as attempted acts of terrorism and cautioned that the number of bombs — and intended victims — could grow. FBI Director Christopher A. Wray issued an appeal for the public’s help to catch the bomber and warned people not to touch suspicious packages.

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“This investigation is of the highest priority for the FBI,” Wray said in a statement. “We ask anyone who may have information to contact the FBI. Do not hesitate to call; no piece of information is too small to help us in this investigation.”

Officials said the packages used as a return address the office of Wasserman Schultz, who chaired the Democratic National Committee during part of the 2016 campaign. One such package used an incorrect address for former attorney general Eric H. Holder Jr., and it was “returned” to her office in Sunrise, Fla., where it was intercepted, according to officials. Authorities do not believe she had anything to do with the packages and think she was a potential victim. A spokesman for Holder declined to comment.

The pipe bomb addressed to Brennan was found in the mail at CNN’s headquarters in New York. Since leaving the government, Brennan has been an outspoken critic of President Trump; he is an on-air analyst for NBC News and MSNBC, rather than CNN.

On Wednesday night, the FBI issued a statement saying investigators found “two additional packages, both addressed to Rep. Maxine Waters, that are similar in appearance” to the other five.

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In a statement, Waters (D-Calif.) said she had been told by police that her office “was the target of a suspicious package that has been referred to the FBI. I am appreciative of the law enforcement entities who intercepted the package and are investigating this matter. I unequivocally condemn any and all acts of violence and terror.”

The packages came with computer-printed address labels, six Forever stamps and return addresses with Wasserman Schultz’s name misspelled, officials said.

Law enforcement officials described the devices as pipes stuffed with explosive material and wrapped in electrical wire and tape, but they provided no detail on how they would have been detonated. The FBI, the Secret Service, the NYPD and other agencies kicked into high gear Wednesday morning trying to determine who was behind the bombs — and how many more may be en route to intended victims. At least two of the devices appeared to have been hand-delivered, according to law enforcement officials.

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“We will not rest until we stop these hazardous devices from being mailed and bring the individual or individuals to justice,” said C. Bryan Paarmann, an FBI counterterrorism official. The devices have been sent to the FBI’s lab in Quantico, Va., for further analysis.

Malcolm Brady, a former Bureau of Alcohol, Tobacco, Firearms and Explosives official who spent decades investigating bomb suspects, said federal agents are carefully poring over the packages for any clues they may hold as to the identity or location of the sender.

“You have to be extremely careful when you examine this stuff, because a piece of tape could have a fingerprint on it,” said Brady.

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Most mail-bombing suspects are “loner types,” said Brady, who added he doubts this bomber made a mistake when he used a bad address for Holder.

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“That looks like an intentional ma­nipu­la­tion of the system, to try to get it to go to the congresswoman. I strongly suspect he wanted that package to go to her. That suggests he’s really focused on her,” said Brady.

Wasserman Schultz issued a defiant statement.

“We will not be intimidated by this attempted act of violence. This appalling attack on our democracy must be vigorously prosecuted, and I am deeply disturbed by the way my name was used,” she said. “Today, my staff and I will hug each other and our loved ones tightly, and tomorrow get back to work serving the people I was elected to represent.”

Amid the frenetic pace of the investigation, some alarms turned out to be false. A suspicious package sent to New York Gov. Andrew M. Cuomo (D) was in fact a thumb drive, according to the NYPD. Authorities also searched an office building in San Diego that houses a newspaper before concluding there was nothing dangerous there.

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The known recipients of the bombs are all frequent targets of conservative politicians, including Trump. Speaking at the White House, the president decried the bombs and pledged that the federal government would bring those responsible to justice.

“In these times, we have to unify,” he said. “We have to come together and send one very clear, strong and unmistakable message that acts or threats of political violence of any kind have no place in the United States of America.”

Those words did not satisfy CNN President Jeff Zucker, who issued a statement sharply critical of the administration’s posture toward the news media.

“There is a total and complete lack of understanding at the White House about the seriousness of their continued attacks on the media,” Zucker said. “The president, and especially the White House press secretary, should understand their words matter. Thus far, they have shown no comprehension of that.”

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An Obama representative referred questions to the Secret Service. Speaking in Florida on Wednesday, Clinton said her family was “fine, thanks to the men and women of the Secret Service who intercepted the package addressed to us long before it made its way to our home.”

She also spoke to the anger pulsing through American politics: “It is a troubling time, isn’t it? It is a time of deep divisions, and we have to do everything we can to bring our country together.”

Politicians of both parties condemned the mail bombs. Senate Majority Leader Mitch McConnell (R-Ky.) called them “attempted acts of domestic terrorism.” New York Mayor Bill de Blasio (D) used similar language.

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“This clearly is an act of terror, attempting to undermine our free press and leaders of this country through acts of violence,” de Blasio said.

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As news of the homemade bombs spread, authorities vowed to ramp up security measures. The NYPD increased patrols in areas linked to public figures and at media offices.

The Senate sergeant at arms sent a message to senators and their staffers advising them to be cautious when handling mail and reminding people not to bring unopened mail or packages from outside into their Senate offices.

About 30 offices associated with the political work of Tom Steyer, a major Democratic donor, have stepped up security significantly in the past 48 hours in light of the threats to Soros and others, said Erik Olvera, spokesman for Steyer’s group Need to Impeach. They have also increased security measures for Steyer, the biggest donor to super PACs supporting liberal causes and candidates this election cycle.

Top Republicans, including Trump and McConnell, have sought for weeks now to cast the rising tide of public anger as actual acts of violence and a phenomenon to be laid at the feet of Democrats.

“I think we know who the culprits are here when it comes to the quality of discourse in the country, and it’s not coming from the Republican side of the aisle,” McConnell said in an Associated Press interview this month.

The contentious confirmation of Supreme Court Justice Brett M. Kavanaugh prompted fierce and occasionally personal protests targeting Republicans on Capitol Hill. GOP leaders chided Democratic leaders, including Clinton and Holder, for delivering remarks that they claimed encourage incivility and potential acts of violence.

But law enforcement has made arrests in recent incidents targeting members of both parties. A New York man was arrested in August for threatening two House Republican leaders; another New York man was arrested last week for threatening GOP senators over Kavanaugh’s nomination. In April, a California man pleaded guilty to threatening to kill Waters. And a Florida man was arrested this month for posting threats on Facebook against Democrats and Republicans who opposed Kavanaugh. Earlier this month, a far-right group called the Proud Boys attacked left-wing protesters outside an Oct. 12 Republican Party event in Manhattan. New York police have since arrested several members of the group.

The devices sent to Clinton, Obama and Soros this week were all pipe bombs placed inside plain manila brown envelopes with the addresses typed on stickers, according to a law enforcement official. The official said those three devices appeared to be capable of exploding and causing injuries.

Authorities urge anyone who receives a suspicious package to contact law enforcement, the official said.

The devices were sent out just months after a 23-year-old in the Austin suburbs set off a string of package explosives in that region, killing two people and wounding several others. That bomber delivered some in person and sent others through the FedEx system, which enabled authorities to track him down.

Unlike the packages intercepted before reaching Obama and Clinton, the device sent to CNN was found while its building was teeming with employees. CNN’s offices at the Time Warner Center in New York evacuated suddenly Wednesday morning after the suspicious package was discovered there.

The network broadcast footage of its staffers and others from the building flooding the Manhattan streets below, where anchor Jim Sciutto could be seen on a cellphone calling in on the air. Zucker wrote in a letter to employees that the center was “evacuated out of an abundance of caution” after the package was found in the mailroom. He also told employees that CNN had checked on its other bureaus but found no other devices.

Chi Li, 28, who works at a technology company near CNN’s building, left to run an errand and came back to find the area closed off.

“I always think it’s so cool to be so close to CNN,” she said. “Maybe now everyone will stop calling them enemy of the people. ‘Fake news.’ ”

As investigators continued to explore the devices and their origins, White House officials and others in Washington decried the string of packages.

“We condemn the attempted violent attacks recently made against President Obama, President Clinton, Secretary Clinton, and other public figures,” Sarah Sanders, the White House press secretary, said in a statement Wednesday morning. “These terrorizing acts are despicable, and anyone responsible will be held accountable to the fullest extent of the law.”

Vice President Pence posted a similar statement, calling the devices “despicable” and saying that anyone “responsible will be brought to justice.” Trump chimed in after, writing: “I agree wholeheartedly!”

Suspicious letters and packages have been sent to numerous public figures, including President Trump’s children. Donald Trump Jr., the president’s eldest son, tweeted: “As someone whose family has directly been the victim of these mail threats I condemn whoever did this regardless of party or ideology. This crap has to stop and I hope they end up in jail for a long time.”

A letter was sent to Trump Jr.'s home earlier this year that resulted in his wife going to the hospital. A man later pleaded guilty to sending threatening letters with white powder to Trump’s sons and other public figures.