HUNDREDS of Mitchelton State High School students have fled a fire in the school's science block.

Queensland Fire and Rescue crews raced to douse the flames, which damaged the multi-storey building on the corner of Dundal St about 8.30am Monday.

A staff member alerted administration as soon as the fire broke out in a storeroom of the science block.

School Principal John Searle said no one was injured.

He praised staff and the 380 students for a successful evacuation of the school.

"All students were accounted for within the first 10 minutes of the evacuation," he said.

QFRS Northern zone acting superintendent Bevan Moore said the fire was contained by 9.38am, but investigators would have to wait until the building, which contains asbestos building materials and potentially hazardous chemicals, had been made safe.

Mr Moore said firefighters knew there was the risk of an explosion if the flames spread to the next door science lab.

Mr Moore said asbestos materials were still intact and did not pose a risk to neighbouring properties.

Students waited calmly on the school's tennis courts until all parents were notified the school would be closed for the remainder of the day.

A pick-up point has been arranged at nearby Mitchelton State School for some students.

Mr Searle said he expected class would resume on Tuesday.

Six fire crews, including a hazardous materials unit, were on scene about 10am, along with five police units and at least one ambulance.