Homicide detectives have charged an 18-year-old man with murder over the Love Machine nightclub shooting in Melbourne's inner south-east, which claimed the lives of a security guard and an innocent bystander.

Key points: Jacob Elliott is the second person charged over the shooting

Jacob Elliott is the second person charged over the shooting He is accused of two counts of murder and three counts of attempted murder

He is accused of two counts of murder and three counts of attempted murder Moussa Hamka, 25, faced court on Sunday accused of being an accessory to murder

Richard Arow, 28, and Aaron Khalid Osmani, 37, died in hospital in the days after bullets were sprayed from a moving car at the crowd outside the nightclub in the early hours of April 14.

Four others were injured in the attack.

Jacob Elliott was charged with two counts of murder and three counts of attempted murder after being arrested in Southbank on Monday morning.

Detectives also executed a search warrant at a property in Bundoora, in Melbourne's north.

Mr Elliott appeared at the Melbourne Magistrates' Court on Monday, where he held back tears and sniffed as he sat in the dock.

Jacob Elliott was driven by police to court on Monday. ( AAP: David Crosling )

Family and other supporters sat in the court room for his appearance.

The prosecution asked for 14 weeks to complete a hand-up brief to allow investigators time to go through "many hours" of CCTV footage and complete forensic analysis.

Mr Elliott did not apply for bail and people cried out "love you, Jacob" when he was led away to the cells.

One of Mr Elliott's supporters also lashed out at a journalist inside the court room who enquired about a suppression order that covers the accused's home address.

"It's our f***ing house," the supporter yelled.

Breakthrough arrests first in murder case

Over the weekend police arrested 25-year-old Moussa Hamka, who was charged with being an accessory after the fact to murder, possessing a firearm, stalking, making threats to kill and other offences.

Mr Hamka appeared before the Melbourne Magistrates' Court on Sunday and is due to appear again in court today.

The court heard that police are still looking for other potential co-offenders.

Moussa Hamka was remanded in custody. ( Facebook )

The two arrests are the first in the investigation and come after Mr Arow's girlfriend and mother made an emotional plea for anyone with information about the shooting to come forward.

His girlfriend Rebekah Spinks said Mr Arow was "the strongest man with the softest heart".

"What this has done to the family is actually so catastrophic and it doesn't get any better every day. It's hard, and we're just struggling, and we just take every day as it comes," she said last month.

The Arow family had fled war-torn Sudan before arriving in Australia in 2002.

Mr Osmani's family said the security guard was "a very loving and caring person" who was taken too soon.

They spoke as police released CCTV vision of a maroon Ford ute they believed was linked to a black Porsche thought to be driven by the attackers.

Last week police released images of a car they believe was accidentally torched following the shooting.

Police said the investigation remained ongoing, and continued to appeal for anyone with information about the shooting or the vehicles to contact them.

Anyone with information is asked to contact Crime Stoppers on 1800 333 000.