Collingwood recruit Daniel Wells is now looking increasingly unlikely to play in round one following yet another injury setback.

The injury-prone veteran, who joined the Pies on a three-year deal from North Melbourne at the end of last season worth a reported $1.8 million, sustained a knock to his calf during a VFL practice month earlier this month.

He has since been managed with a view of having him available for round one, however, the 32-year-old missed training again on Monday and is now a long shot to be fit for the opening round.

Wells has only managed 31 games over the past three seasons due to Achilles and calf injuries.

The Magpies face the Western Bulldogs on Friday night in the opening round.