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Tooth Regeneration

Global dental industry has undergone a drastic transformation over the last decade. Teeth are among the most important part of human beings, which helps in performing various activities ranging from feeding to articulation to that of esthetics, loss of which could led to physical and psychological issues. As such, many advancements have been made in the past to cater to growing dental issues among patients, including denatures and dental implants.

Though major advancements has been made in the field of dentistry, emotional connect with natural teeth and high attributes of natural teeth has led to attention on development of biologically engineered teeth (tooth regeneration). Various new companies have emerged at the global level to address and capitalize on highly lucrative opportunities in the market. Industry leaders and universities across regions are actively working towards developing novel products and solutions to develop new teeth. Once commercialized, tooth regeneration market is expected to capture much of the dental implants market.

Research are carried out by various universities and companies to understand the feasibility of stem cell based regenerative medicines – tooth regeneration. While stem cell is the prominent technology in research for tooth regeneration, some institutions are also leveraging laser, drug and gel as mediums to regenerate teeth. For instance, Wyss Institute at Harvard University is engaged in research related to tooth regeneration using lasers. Tooth generated using stem cells are currently under research across the globe. Dental pulp stem cells, stem cells from human exfoliated deciduous teeth (SHEDs), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), dental follicle progenitor cells (DFPCs) are key stem cells on which research are carried out.

Tooth regeneration market industry players are expected to witness increase exponential increase in their revenue. Early entrants are expected to gain significantly from first mover advantage. The market is expected to be primarily driven by high tooth loss prevalence coupled with focus of major players on product innovation and need for aesthetic look among target population. Dental cavities and issues are treated with conventional invasive methods such as dental implants and root canal. Development of non-invasive methods such as tooth regeneration would be a major breakthrough innovation and would replace dental implants. A 2009 nationwide survey by the Nova Southeastern University in the U.S. revealed that around 96% of dentists expect stem cell regeneration to dominate the future of dentistry industry.

Tooth regeneration market revenue is expected to be further driven by various macroeconomic factors. Various regulatory issues coupled with increasing spending on dental healthcare is expected to further support growth of tooth regeneration market growth. Favorable demographic trends along with expansion of commercial insurance and Medicaid insurance represents favorable market environment for growth of dental products, including those undergoing research. Moreover, global dental care expenditure is expected to rise at 5% annually between 2016 and 2024.

The global tooth regeneration addressable market is expected to be pegged at an astounding 5,980 million dental implant procedures by 2027 and is expected to expand at a CAGR of 8.5% during the period 2019 – 2027. However, commercialization of the product is expected to take place post-2024.

Figure 1. Global Tooth Regeneration Addressable Market

Source: Coherent Market Insights Analysis (2019)

Geriatric population demographics has emerged as the highest revenue contributor among population demography segment

Geriatric segment is expected to dominate the dental implants market throughout the forecast period. The segment accounted for 66.8% of global industry revenue in 2015. According to NIH, geriatric population have average 18.9 remaining teeth. Around 23% of geriatric population have no teeth, creating favorable market scenario for industry players. Over 18 million dental procedures are expected to be carried out among geriatric population between 2017 and 2027. Commercialization of tooth regeneration is expected to create lucrative market opportunity for industry players. North America and Europe are expected to collectively account for major share of global procedures by 2027.

Asia Pacific is expected to dominate the tooth regeneration market revenue post 2020

Tooth regeneration addressable market is expected to be highest in Asia Pacific, with China and India positioned as the major growth engines. Emergence of tooth regeneration is expected to capture this market. Also, the number of dental procedures is expected to grow at the highest CAGR of 10.9% in Asia Pacific between 2019 and 2027.

North America and Europe are expected to lose position to Asia Pacific by 2020. It is primarily attributed to increasing healthcare spending coupled with significant geriatrics population presence in Asia Pacific.

Tooth regeneration market players need to invest in R&D to harness stem cell technology to develop and commercialize tooth regeneration technology

Tooth regeneration market players are focused towards research and development to commercialize the target industry. Companies such as Straumann and DENTSPLY are working closely with some of the leading universities to understand the project feasibility. In 2015, researchers at University of Southern California (U.S) created gel to regrow enamel. Moreover, nanoparticles is also gaining momentum to boost dental tissue engineering. Various institutes such as Nova Southeastern University, Tufts School of Dental Medicine, University of Southern California, Wyss Institute at Harvard University, University of Nottingham, Institute National de la Sante et de la Recherche Medicale (France), etc are engaged in tooth regeneration technology. Various products are in the pipeline, commercialization of which is expected to happen post-2024. Most of these companies are focused towards enamel regeneration. Unilever UK developed ‘Regenerate Enamel Science’. The company holds 5 international patents for its NR-5 technology. The brand claims to regenerate 82% of the eroded enamel within 3 days. Many products are expected to emerge in near future creating exponential market opportunity for industry players.