When Susan Zirinsky was named the new president of CBS’s troubled news division in January, she said she wanted to unite her team “both functionally and spiritually.”

She is about to put that mission to the test.

CBS News, whose Cronkite-and-Murrow tradition was shaken last year by a series of sex scandals, is set to make sweeping changes to its morning and evening anchor lineups in a roll of the programming dice that the network hopes can lure back a shrinking audience.

The moves would be Ms. Zirinsky’s first to put her imprint on the network where she has worked for nearly five decades — and whose fortunes fell after painful revelations of workplace misconduct felled the company’s chief executive, Leslie Moonves; its star morning-show host, Charlie Rose; and Jeff Fager, executive producer of its most popular and prestigious show, “60 Minutes.”

Ms. Zirinsky is expected to announce her shake-up as soon as Monday, ahead of the network’s annual presentation to advertisers on May 15. The latest round of changes and tensions at CBS News were described by several people granted anonymity to describe sensitive internal discussions.