Two security guards were shot dead at a Las Vegas hotel and casino at 6.30am on Saturday.

The shooting took place in a hotel room at Arizona Charlie's Decatur Hotel and Casino when 29-year-old gunman Christopher Olague opened fire on two guards responding to a report of a disturbance.

According to the LA Times, the guards had entered the room on the fourth floor and were shot by Olague, who was alone in the room. He used a handgun.

Following the shooting Olague escaped and tried to carjack two motorists who managed to fend him off.

He was located soon afterwards in the garage where he had shot himself in the head.

He was taken to University Medical Center, where he was listed in critical condition.

'I don't expect him to live,' Las Vegas Police Lt. Dan McGrath said.

Scroll down for video

The shooting at Arizona Charlie's, a casino west of the Las Vegas Strip, has left two security guards dead

Further information on the shooting, including a possible motive for the act, wasn't immediately clear.

The names of the victims have not been released.

Arizona Charlie's Decatur is located west of the Las Vegas Strip, and is one of two Arizona Charlie's locations in Las Vegas.

The deadly shooting comes just a day before New Year's Eve, a major holiday for tourism in Las Vegas, and just months after the deadly Mandalay Bay shooting, where gunman Stephen Paddock killed 58 people attending a music festival on October 1.

The hotel was reportedly fully booked for New Year's Eve weekend.

Christopher Darcy, deputy chief of the Las Vegas Metropolitan Police Department investigative services division, said the incident had no relation to terrorism or the Mandalay Bay incident.

'We want to assure the public that Las Vegas is a safe community and this is in no way related to events on the Strip or terrorism,' he said.

Homeland Security officials and the Las Vegas police department are gearing up for New Year's Eve, which has been deemed a National Special Security Event this year.

Clark County Sheriff Joe Lombardo told the Los Angeles Times that there would be more snipers, aircraft surveillance and more than 4,000 metal barricades along the Las Vegas Strip, which will be pedestrianized for the celebration ringing in the new year.

The shooting comes one day before New Year's Eve, a major event for Las Vegas, and months after the deadly Mandalay Bay shooting

Joseph Lombardo of the Las Vegas Metropolitan Police Department is pictured speaking at a press conference about New Year's Eve preparations

The increased security comes even though the city expects fewer visitors this New Year's Eve than in years past (334,000 people; down 1.2 percent from last year).

The Strip, along with the city's McCarran International Airport, will be patrolled by 300 National Guard troops, Newsy reports.

Meanwhile, Nevada Department of Transportation officials told the Los Angeles Times that around $350,000 would be spent on protective measures.

'Nobody puts on a New Year's Eve show like Las Vegas, and never will it be as safe as it will be this year,' a Clark County official told the Los Angeles Times.

Revelers will also not be allowed to bring large baggage into the pedestrianized section of the Las Vegas Strip.