London police seized almost $300,000 worth of fentanyl from a west London home on Wednesday, the largest such bust in the city's history.

Police say guns and drugs officers with the guns and drugs section saw what they believed to be a drug deal going on in a rental vehicle in the area of Oxford Street East and Adelaide Street. The vehicle was stopped and the driver arrested without incident.

Officers got a search warrant on Castlegrove Boulevard and found:

Just over $295,000 worth of fentanyl

Almost 37 grams of cocaine worth $3,600

About $13,000 in cash

Digital scales

Two Naloxone kits

A 30 year-old woman and a 43-year-old man, both of London, have been jointly charged with two counts of possession for the purpose of trafficking.

The guns and drugs section includes members of the London police, RCMP and OPP.