The Massachusetts state gambling regulator, which granted a casino license to Wynn Resorts Ltd. in 2014, said Friday that it will conduct a regulatory review following an article in The Wall Street Journal that reported allegations of sexual misconduct by Chief Executive Steve Wynn.

“The Commission is now aware of and is taking very seriously the troubling allegations detailed in The Wall Street Journal article,” a spokeswoman for the Massachusetts Gaming Commission said in a statement. “The suitability and integrity of our...