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To humanely kill a rodent by asphyxiation, you’ll need baking soda, white vinegar, a hose, a sealable plastic container, and a plastic bag. Once you’ve trapped the rodent in the plastic container, pour a few cups of baking soda into your plastic bag. Then, place a jug of white vinegar into the bag without mixing it with the baking soda. Cut a hole in the lid of the plastic container and attach the hose to it. Place the other end in the plastic bag and seal it with a rubber band. After you’ve connected the hose to the bag, slowly pour the vinegar onto the baking soda, which will make carbon dioxide and suffocate the rodent. If you don’t have access to these materials, the best way to instantly kill a rodent is to hit it hard in the head. For more tips, including how to kill a rodent with a spring trap, read on.