Sen. Mitch McConnell Addison (Mitch) Mitchell McConnellObama calls on Senate not to fill Ginsburg's vacancy until after election Planned Parenthood: 'The fate of our rights' depends on Ginsburg replacement Progressive group to spend M in ad campaign on Supreme Court vacancy MORE (R-Ky.) has a clear and simple message for his party: Success depends on unity.

In an interview with The Hill, the Senate majority leader said he has told his GOP colleagues not to expect any help from Democrats on an array of legislative priorities.

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In contrast to past years, when McConnell had to face down rebellions from conservative colleagues — most notably Texas Sen. Ted Cruz Rafael (Ted) Edward CruzSenate Republicans face tough decision on replacing Ginsburg Cruz: Trump should nominate a Supreme Court justice next week Renewed focus on Trump's Supreme Court list after Ginsburg's death MORE (R) — the entire Senate GOP conference appears to be on the same page. How long that lasts remains uncertain, however.

“The only way you can achieve success in an environment like now, where there’s not much bipartisanship, is for us to have our act together and to work out our differences among ourselves,” McConnell said Friday.

During former President Obama’s administration, McConnell said he had to contend with “individuals” in the Senate and House who “just really enjoy the publicity associated with doing something the vast majority of Republicans didn’t agree with, and it was a great headline producer.”

After a highly unusual and charged election year, McConnell is looking forward to making new laws in 2017. Against the odds, McConnell preserved his GOP majority in November and now has a willing partner in the White House. The relationship between President Trump and McConnell was tenuous at best throughout 2016. But times have changed. McConnell, who refused to answer questions about Trump in the fall, last week compared him to President Andrew Jackson, the nation’s first populist commander in chief.

Ten Senate Democrats are running for reelection in 2018 in states that Trump won last year. McConnell is expecting that Senate Minority Leader Charles Schumer Chuck SchumerPelosi orders Capitol flags at half-staff to honor Ginsburg Ginsburg in statement before her death said she wished not to be replaced until next president is sworn in Democrats call for NRA Foundation to be prohibited from receiving donations from federal employees MORE (D-N.Y.) will pull out all the stops to keep them from defecting on big votes.

“We’re not anticipating much Democratic cooperation here,” he said with a laugh.

He says most Democrats are “not interested” in working with the GOP on legislation to repeal and replace parts of ObamaCare and to overhaul the tax code. As a result, Republicans are looking to pass those bills on party-line votes under a special budgetary process that protects them from filibusters.

“When you’re taking that path, you better have your people all lined up, because if you can’t get your own guys together, particularly in the Senate, you can’t get where you want to go,” he said.

Republicans have control of the White House and both chambers of Congress for the first time in a decade, and they know they have a limited amount of time to enact major legislative initiatives such as comprehensive tax reform, which was last accomplished in 1986. At that time, Democrats and Republicans worked together to revamp the tax code. McConnell, who was a backbencher back then, said such a bipartisan endeavor is just not possible now — it’s “a different era.”

Despite the high stakes and the pressure, McConnell seemed comfortable and at ease throughout The Hill’s interview. He stayed on message and calmly dodged questions about policies Republicans have not yet decided on.

McConnell in 2015 became majority leader, his dream job ever since he worked as a junior aide to late Sen. Marlow Cook (R-Ky.).

The Senate electoral map looks quite good for Republicans, who have only eight seats up for reelection in 2018, while Democrats will have to defend 25.

But McConnell, 74, says anything can happen, chuckling over the brimming confidence of Democratic colleagues last year who thought they were a lock to win back the upper chamber. Before the election, media outlets were publishing profiles of Schumer, assuming he would be the next Senate majority leader.

“I sat here and observed on a daily basis my soon-to-be counterpart, Sen. Schumer, giving interviews on his agenda, measuring the curtains,” he recalled with a wry smile.

McConnell, who has a reputation as one of the shrewdest tacticians on Capitol Hill but sometimes draws criticism even from GOP colleagues for being too focused on politics, says he’s now entirely focused on governing.

“Rather than becoming consumed about what might happen in 2018, we need to try to succeed,” he said.

McConnell, an institutionalist who reveres the Senate, said Republicans don’t work for Trump. He pointedly noted that the Senate decides its own rules when asked about pressure from the White House to strip senators of the power to filibuster Supreme Court nominees.

Over the years, conservative groups have taken shots at McConnell on a variety of issues. But they have no complaints about his decision to not vote on Merrick Garland, Obama’s 2016 Supreme Court nominee. Now, late Justice Antonin Scalia’s seat will be filled with a conservative. Trump is scheduled to announce his pick on Tuesday.

Trump and McConnell are both dealmakers, but they don’t see eye-to-eye on trade, Russian sanctions and other matters. What’s more important than their differences, McConnell said, is their shared desire to cut tax rates, simplify the tax code and reverse what he calls the “rampage” of overregulation under Obama.

He says regulatory excess is the chief culprit responsible for the nation’s tepid economic recovery and scoffs at the Democratic narrative that frames Obama as a savior who turned around a national economy severely damaged by former President George W. Bush’s mismanagement.

“Obama didn’t have a single year of 3 percent growth, and the statute of limitations on blaming Bush ran out a long time ago,” he said.

Unlike Trump, McConnell rarely talks publicly about the stock market. But it has gone up because of Trump’s victory, McConnell said.

“Everybody I know who watches the market thinks the reason it has been booming is the expectation of regulatory relief and tax reform,” he said.

As partisan as the atmosphere is in Washington, McConnell knows that he’ll still need centrist Democrats to join him for the 115th Congress to be a success.

He says that Republicans cannot entirely replace ObamaCare under reconciliation — the special budget process that empowers the majority party to enact legislation with only 51 votes.

Some healthcare reforms, such as allowing companies to sell insurance across state lines or other policy changes that have a negligible budgetary impact must be adopted with 60 votes. That means winning over centrists such as Sen. Joe Manchin Joseph (Joe) ManchinBiden promises Democratic senators help in battleground states Senate leaders quash talk of rank-and-file COVID-19 deal OVERNIGHT ENERGY: House Democrats tee up vote on climate-focused energy bill next week | EPA reappoints controversial leader to air quality advisory committee | Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' MORE (D-W.Va.) and Heidi Heitkamp Mary (Heidi) Kathryn HeitkampCentrists, progressives rally around Harris pick for VP 70 former senators propose bipartisan caucus for incumbents Susan Collins set to play pivotal role in impeachment drama MORE (D-N.D.), who are up for reelection next year.

“[Red-state Democrats] will be necessary,” he concedes.

After spending the past two years playing defense, when Republicans had to defend 24 Senate seats in the 2016 election cycle, McConnell — an avid sports fan — is eager to play offense.

“I’m assuming that each of them will be calculating whether it’s to their advantage to be cooperative or not,” he said of the 10 Democrats up for reelection in pro-Trump states.

“I’m hoping that frequently they will conclude that it’s actually good for them to be helpful to us,” he said.