Fourth time’s a charm when it comes to box office gold.

The latest entry in the Resident Evil franchise has grossed more than $280 million at the box office internationally, making it the most successful production in Canadian film history.

Resident Evil: Afterlife, starring Mila Jovovich and shot in stereoscopic 3-D, debuted earlier this year to positive reviews and strong audiences. The film, like its predecessors, was shot entirely in Toronto and the GTA.

Based originally on a video game, the movie was produced by film veteran Don Carmody, who held the record for the previous top box office grossing Canadian movie, the 1981 teen sex comedy Porky’s.

Carmody, co-producer of the Oscar-winning musical Chicago, is a longtime supporter of Canadian film.

“We had a terrific experience making and posting this latest in the Resident Evil series. The local Toronto cast and crew were exceptional as always and proved themselves to be world class in mastering the complicated 3-D technology,” Carmody said in a statement.

The Ontario Media Development Corporation noted the Canadian-German co-production helped boost film and television production to $946.4 million in 2009, a 41 per cent increase over the previous year.