The authors thank R. Jakubowicz and M. Krämer for DNA extraction, PCR amplification, and sequencing. The HELIUS study is conducted by the AMC Amsterdam and the Public Health Service of Amsterdam. Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation, the Netherlands Organization for Health Research and Development (ZonMw), the European Union (FP-7), and the European Fund for the Integration of non-EU immigrants (EIF). We gratefully acknowledge the AMC Biobank for their support in biobank management and high-quality storage of collected samples. We are most grateful to the participants of the HELIUS study and the management team, research nurses, interviewers, research assistants and other staff who have taken part in gathering the data of this study. The study reported here was additionally supported by Le Ducq consortium grant 17CVD01 to M. Nieuwdorp and F.B., JPI-HDHL MICRODIET consortium grant to M. Nieuwdorp and F.B., on which I.A. is appointed, and Novo Nordisk Foundation Gut-MMM grant to M. Nieuwdorp and F.B. M. Nieuwdorp is supported by a personal ZONMW-VIDI grant 2013 (016.146.327), on which G.J.B. is appointed, and a Dutch Heart Foundation CVON IN CONTROL Young Talent Grant 2013, on which A.P. is appointed. F.B. is Torsten Söderberg Professor in Medicine and recipient of a European Research Council Consolidator Grant (615362— METABASE). D.H.V.R. is supported by a junior fellowship of the Dutch Diabetes Foundation (2015.81.1840) and by a Marie Skłodowska-Curie Actions global fellowship (708193). The funders had no role in the study design, the collection, analysis, and interpretation of data, the writing of the report, and the decision to submit the article for publication.