In a radio ad released Monday, two women have a phone conversation in Spanish. One says, "Watching the news. I don’t know who am I going to vote for president," and the other replies, "Me neither. But I know that we need John McCain in the Senate now more than ever."

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In May McCain acknowledged that with Trump at the top of the ticket, this could be "the race of my life."

But unlike some vulnerable Republicans in tight races, McCain endorsed Trump but has spoken out against the nominee's harsher statements on immigration and Hispanics.

Most notably, McCain rebuked Trump for questioning Judge Gonzalo Curiel's objectivity due to his Mexican heritage.

Monday's TV ad touts McCain's immigration record — he was a member of the Gang of Eight that passed comprehensive immigration reform through the Senate in 2013.

"The fact that John McCain must think Arizona Latinos don’t understand what he’s said in English just goes to show how long he’s been in Washington and how out of touch he is after 33 years," said immigration activist Yuri Gutierrez in Kirkpatrick's release.

McCain has consistently outperformed Kirkpatrick in the polls and seems to be expanding his lead. An NBC/Wall Street Journal/Marist poll released on Sept. 11 showed the incumbent with a 19-point lead over his challenger.