EXCLUSIVE: Matt Smith will star in Screen Gems’ Patient Zero opposite Natalie Dormer. Stefan Ruzowitzky is directing the Mike Le-scripted action thriller and Vincent Newman is producing.

In Patient Zero, an unprecedented global pandemic of a super strain of rabies has resulted in the evolution of a new species driven by violence. An inexplicably immune human survivor with the ability to communicate with this new species must spearhead a hunt for Patient Zero in order to find a cure to save his infected wife and humanity.

Best known for starring in the BBC series Doctor Who, Smith has stepped it up on the feature front. He stars in Screen Gems’ production Pride And Prejudice And Zombies, as well as Paramount and Skydance’s Terminator: Genisys. Smith most recently played a key supporting role in Ryan Gosling’s directorial debut Lost River opposite Christina Hendricks, Saoirse Ronan and Eva Mendes.

He’s repped by UTA and Troika in the UK.