Homicide detectives are investigating the murder of a Melbourne couple while their children slept.

The bodies of Greg Tucker and his partner Korinne were found inside a home on Darling Street at Moonee Ponds in the city's north-west late last night.

Police say the victims sustained "serious" trauma injuries, but will not say whether a weapon was found.

The couple's children aged 2, 3 and 5 were also in the house but were not hurt.

Police and local residents at the scene of a double murder in Moonee Ponds. ( AAP: Julian Smith )

A 44-year-old Meadow Heights man was found sitting in the driveway with minor injuries.

He was arrested before being taken to hospital and is being questioned by police.

Detective Senior Sergeant Shane O'Connell says the three young children are now in the care of family members.

"Whether or not the children were present, whether they've seen or heard anything that's gone on, the fact that we've got three young children aged 5 and below, and they're in a house where such a horrific thing has occurred, is just tragic," he said.

Neighbour says deaths are 'devastating'

One neighbour says she was shattered when she heard about the attack.

"It's just devastating, a beautiful young couple with three young children," she said.

"Terrible, in a lovely quiet street, for this to happen."

Family friend Ali Simsek says the family moved into the house earlier this year.

"Lovely people, I know his family, parents, sister-in-law, kids," he said.

"He's got lovely kids, and now without parents three little kids - very sad."

The alleged killer parked around the corner from the Tuckers' house.

Police have removed the vehicle for forensic testing.

They also taped off a nearby block after finding a blood trail along the footpath.