Five suspects are being sought in the fatal shooting of 20-year-old Toronto man Nathan Miller in Hamilton Thursday night, says Hamilton Police.

Miller was found in a downtown Hamilton home, one neighbours commonly referred to as a "crack house" with regular fights and late-night visits. Police were often called to the home, they said.

Nathan Miller was shot on Madison Avenue in Hamilton back in January. (Jeff Green/CBC)

Detective Sergeant Joe Stewart said Hamilton Police are working with Toronto Police to find the five suspects, but details a day after the city's first homicide of 2015 are slim.

"We have no idea what the motive is," Stewart said, adding Miller does not have a criminal record and that he has "no evidence" to suggest if Miller was known to the suspects at large.

Hamilton Police say on Thursday, a group of five men were allowed into the home, but once inside, they shot Miller and fled.

Emergency crews were called to the scene at 9:42 p.m. Thursday. Hamilton EMS commander James Summers said paramedics found a man shot multiple times.

Police say the shooter was a stocky 6-foot-tall man. Two of the men who entered the home with the shooter were described as 6-foot-5 tall.

Neighbours say the home, which remained taped off and was under examination by a forensics team Friday morning, had frequent visitors, fights and late night arguments.

Police respond to a fatal shooting at 28 Madison Ave. on Thursday night. (Tony Smyth/CBC)

"Three, four in the morning they've got people coming and going, yelling and screaming in the alleyway waking my kids up," said Joe Plainie, 26, who lives behind the home cordoned off by police tape near Cannon St. E and Sanford Ave.

On Friday morning, Hamilton Police were going door to door, canvasing for any information.

Neighbour Aaron Spafford, 30, said an incident "was bound to happen, it was a f------ crack house."

"So many people in and out of there... Everytime there's a government cheque, they're f------ cops here. It's nothing new to the neighbourhood," Spafford said. People fighting out front, throwing bottles… I'm not surprised."