Over 70 percent of employees affected by the latest round are based in North America, with the remainder spread across Asia, Europe, Latin America and the Middle East, according to TechCrunch. Uber has laid off more than 1,100 employees across the three rounds, and it also asked some staff members to relocate.

"As you know, over the past few months, our leaders have looked carefully at their teams to ensure our organizations are structured for success for the next few years," CEO Dara Khosrowshahi wrote in an email to employees Monday. "This has resulted in difficult but necessary changes to ensure we have the right people in the right roles in the right locations, and that we're always holding ourselves accountable to top performance."

In the second quarter, Uber reported a loss of over $5 billion, much of which was due to stock-based compensation awards to employees after its May IPO. It's set to post its Q3 earnings November 4th.