Two Palestinian protesters were killed and 98 were wounded in clashes with Israeli security forces in the West Bank and the Gaza Strip on Friday. Thousands of protesters took to the streets in a second "Day of Rage" following U.S. President Donald Trump's decision to recognize Jerusalem as Israel's capital.

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A 30-year-old Palestinian was killed by IDF gunfire in the Khan Younis region in Gaza, according to Palestinian health officials. Another man, in his fifties, was killed in a clash in northern Gaza.

Open gallery view Palestinian Muslim worshippers during Friday prayer at the al-Aqsa mosque compound in the Jerusalem's Old City on December 8, 2017. Credit: AFP Photo/ Ahmed Gharabli

Some 3,000 protesters took part in demonstrations around the West Bank, including in the cities of Ramallah, Hebron, Tul Karm and Nublus. According to the Israeli army, protesters threw molotov cocktails and rocks. Security forces responded with live fire, rubber bullets and tear gas. Twenty-eight protesters were arrested.

Fifty-two Palestinians were wounded by rubber bullets at protests in the West Bank, the Palestinian Red Crescent reported. Eleven were reportedly wounded by live fire. Dozens were treated for tear-gas inhalation, according to the Red Crescent.

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Some 4,500 Palestinians protested in six locations along the Strip's border with Israel. The Red Crescent said 15 people were hurt by live IDF gunfire, and a further 20 wounded by rubber bullets in the area of Khan Younis, in the south of Gaza. Three people are reported to be critical condition. Clashes also took place in Jabalia and the Nahal Oz area, along the Strip's border.

A number of protesters have been arrested at Jerusalem's Damascus Gate, where skirmishes between Israeli police forces and Palestinian protesters took place after tens of thousands of Muslim worshippers attended Friday prayers in Al-Aqsa Mosque at the Temple Mount compound.

Open gallery view Palestinian protesters carry a wounded man during clashes with Israeli troops near an Israeli checkpoint in the West Bank city of Ramallah on December 8, 2017. Credit: Abbas Momani / AFP

Further protests were held in the Israeli towns of Umm al-Fahm, Kalansua and Kfar Kana. One man was arrested on suspicion of throwing rocks in the city of Nazareth, where a protest was held.

Thousands of protesters also took to the streets of the Jordanian capital of Amman after midday prayers to protest Trump's announcement. Similar protests were held in Iraq, Egypt and Turkey, with more expected on Saturday.

Friday's protests followed a "Day of Rage" on Thursday, in which at least 20 Palestinians were wounded in the West Bank, East Jerusalem and Gaza in clashes with Israeli soldiers.