On Wednesday alone, Endgame raked in $25.2 million domestically. Heading into the weekend, the movie will retain its No. 1 position and, according to those with access to early tracking numbers, is expected to pull in somewhere around $180 million stateside.

Overseas, Endgame's top grossing territories so far have been China ($459.4 million), the U.K. ($68.2 million), Korea ($60.3 million), Mexico ($48.6 million) and India ($40.9 million).

Debuting stateside this weekend at the box office are the rom-com Long Shot, the animated offering UglyDolls and the thriller The Intruder.

Starring Seth Rogen and Charlize Theron, Lionsgate's Long Shot — which debuted at SXSW to positive reviews and boasts an 86 percent fresh rating on review aggregator Rotten Tomatoes — follows a journalist turned speech writer who helps his childhood crush turned politician on her bid for the White House. The pic is expected to earn somewhere in the $9 million-$14 million range.

UglyDolls, STXfilms' first foray into animation — with a musical voice cast that includes Nick Jonas and Kelly Clarkson — is looking at a debut in the teen millions, with those with access to early surveys placing the stateside bow around $12 million to $13 million. The film currently has a 42 percent score on Rotten Tomatoes.

The Megan Goode and Michael Ealy-fronted The Intruder, which also sees Dennis Quaid play an obsessive widower, currently has a 27 percent rating on Rotten Tomatoes. The title from Sony's Screen Gems was made on an $8 million budget and is tracking for an opening around $9 million, but some predict it could have a domestic box office launch in the low-teen millions.