If not for the plunge in Apple's stock on Thursday, Wall Street would've been laser-focused on the monumental tie-up between biotechnology giants Bristol-Myers Squibb and Celgene, CNBC's Jim Cramer said. "If not for the Apple shortfall today — worst in 6 years, by the way — this Bristol-Myers-Celgene deal would've been all we talked about," Cramer said after stocks ended the day lower. But the $74 billion deal isn't just important because of its enormous price tag, the "Mad Money" host said. It also offers a read on a space that might be reaching its limits and is due for a "long-awaited" wave of consolidation, he said. "The fact is, there are simply too many drug companies out there that can be more valuable to potential acquirers than they are to the stock market itself," Cramer explained, pointing to the numerous companies that have whittled down their drugmaking franchises to cover only one illness or produce just one type of medication. "[The deal] shows you how Bristol-Myers needed more than just Opdivo," its leading cancer treatment, he said. "The company needs a suite of anti-cancer products and pipelines. With Celgene, maybe it finally has the diversification that it's been looking for." To read more about the Bristol-Myers-Celgene deal, click here.

Cramer recommends buying "safety stocks"

Clorox products are displayed for sale in a supermarket in New York. Scott Eells | Bloomberg | Getty Images

Investors should opt for stocks that do well during recessions as economic issues converge to put serious pressure on U.S. markets, Cramer said Thursday as the major indexes tanked. The closed 660 points lower as shares of Apple, which Wednesday night, dragged on the broader market. The and indexes fell 2.47 and 3 percent, respectively. But Apple wasn't the root cause of Thursday's pain, he argued. Instead, he said the iPhone maker's shortfall was a "byproduct" of interest rate agenda for 2019, which the central bank would include two rate hikes. "As a stock-picker, I have to say that [Fed Chair Jerome] Powell's made it a little more difficult to make money," said the "Mad Money" host, adding that the Fed's resilience in the face of an economic slowdown could seriously damage stocks. Because of the Fed's actions, certain investments that should be good bets here simply aren't, he warned. "So, what do you do? Well, you buy the stocks of companies that do well in a recession — even though I don't think we're going into one — that are also bolstered by lower raw costs," Cramer said, specifically highlighting , and . "They're the safety stocks. That's what's worth owning." Click here to read more.

2018's fourth-quarter winners and losers

Jim Cramer on "Mad Money." Scott Mlyn | CNBC

The best and worst stocks of 2018's final quarter — a that saw the major averages erase their gains for the year — offer key insight into how investors should position their portfolios in 2019, Cramer says. The stock market turned treacherous in late 2018 as concerns about global growth, rising interest rates and U.S.-China trade took hold on Wall Street. The action, often characterized by dramatic, several-hundred-point swings, led the major indexes to log their worst annual performances since the financial crisis. But after reviewing the biggest winners and losers for Q4, Cramer found some pockets of opportunity that investors can use to their advantage in the new year. Click here for his favorite picks for 2019.

AMN Healthcare Services CEO on health-care job market

Susan Salka, CEO of AMN Healthcare. Adam Jeffery | CNBC

The health-care industry is swimming upstream when it comes to unemployment, says the CEO of hospital staffer . While the headline U.S. unemployment rate in 2018, signaling powerful hiring trends, the health-care space has been a pocket of pain when it comes to hiring, Susan Salka, the president and CEO of AMN, told CNBC on Thursday. "We have a lot of things driving our industry, certainly starting with an aging population, which drives utilization of health care," Salka said in a Thursday interview with Cramer. "But it also creates shortages within the health-care workforce." "We have really severe shortages within nursing, physician, allied, and even within leadership," she said on "Mad Money." So we're really seeing those two things come together right at the worst time, probably, for health care, but that's where AMN comes in." Click here to watch and read more about her full interview.

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