Police have issued a public safety alert after one person died and four others were hospitalized as a result of drug overdoses at downtown nightclubs overnight.

Police say the first incident happened at around 12:45 a.m. when a 24-year-old woman was located in distress in the Bathurst and Adelaide streets area, which is near Uniun Nightclub.

Police say that officers were advised that the woman had ingested a drug. She then collapsed and was rushed to hospital, where she was later pronounced dead.

Police say another woman then collapsed in the same area at around 1 a.m. and was taken to hospital. She is expected to survive.

Meanwhile, police say that they were also made aware of four other overdoses at Rebel Nightclub on Polson Pier at around 1:30 a.m.

Police say that three of those victims, two women and one man, were transported to hospital in serious condition while the fourth victim was treated on scene.

The suspected overdoses may have involved the drug MDMA, according to police.

“We deal with overdoes probably every day. It is an unfortunate part of our business. But to see the severity of injuries that we are talking about and the number of them is something that is unusual,” Const. David Hopkinson told CP24 on Saturday. “We have to investigate where this is coming from.”

Hopkinson said that it is possible that the drugs ingested by the victims were mixed with another substance but he said it’s too early to speculate on that.

He said anyone that has had an adverse reaction to illegal drugs should feel comfortable coming forward to Toronto police.

“We are urging people to not be afraid to report what has happened,” he said.

Clubs both operated by INK Entertainment

The overdoses in the early hours of Saturday morning all took place at nightclubs operated by INK Entertainment.

In a statement INK Entertainment said that it is “shocked and saddened” to hear of the overdoses.

The company also expressed their “heartfelt condolences” to the family and friends of the woman who died.

“While the causes of these incidents are still undetermined, we are fully cooperating with the police on the investigation,” the statement reads. “Public safety and security is our top priority at INK Entertainment and we will continue to ensure that it remains that way with the highest standard of support”

INK Entertainment said that it has a zero tolerance policy when it comes to drugs and that patrons are subjected to a “full and vigorous” search upon entering their venues.