THE Newman government has been pronounced un-electable despite its huge parliamentary majority, in the wake of the resignation of sacked assistant Health Minister Dr Chris Davis yesterday.

Palmer United Party Queensland leader Dr Alex Douglas said his party's polling showed the government would lose a minimum 44 seats at the next election and may win as few as 18.

Dr Davis, the Member for Stafford, resigned from Parliament citing recent government legislation affecting "critical aspects of our democracy" that went contrary to both his and his electorate's value system.

"I would never have stood for Parliament on such a platform, nor do I believe I would have been elected," he wrote in a letter to the Speaker Fiona Simpson.

Opposition Leader Annastacia Palaszczuk described Dr Davis's resignation as a vote of no confidence in the government.

She has called on Mr Newman to immediately call a by-election in Stafford.

Reader poll Does Campbell Newman deserve to keep his overwhelming majority next term? This poll ended on 24 May 2015. Current Results No, he'll be lucky if he keeps government 76% No, we'd all be better off with some balance 12% Yes, but he'll probably lose most of his lead 5% Yes, the LNP have delivered and they'll be rewarded for it 5% This is not a scientific poll. The results reflect only the opinions of those who chose to participate.

Recent polling in Dr Davis's electorate put disapproval of the Premier at 58.4% with only 23.1% support.

The poll also found 59.9% opposed the Government's uncapping of donation limits. Only 15.1% supported changes made a week ago to the CMC, the state's peak corruption body.

If Dr Davis had remained in parliament and run as an independent at the next election he would almost certainly have retained the seat.

Dr Douglas said PUP polling showed the Newman government had lost the North Queensland sugar seats and would be "absolutely smashed" at the next election.

He said antipathy to the LNP had been maximised by the Abbott government's Federal Budget which he said had created a "perfect storm".

Mr Newman told the Brisbane Times yesterday that the LNP as a team had attempted to accommodate Dr Davis's concerns and take his issues on board.

"It's a pity he feels that he hasn't been able to deliver, because he has been able to deliver," Mr Newman said.

"I make the point that he was offered a briefing on the electoral bill and he didn't even make the briefing."

He said the LNP did not have a problem with dissent.