Since opening in 2017, it has presented itself as a kind of quietly revolutionary space that “reimagines” the way women balance work, family and inspiration. The space is one of several women-focused businesses — like The Wing and The Riveter — that opened around the country in the Trump era, embracing messages of empowerment to help sell co-working memberships. At the Jane Club, women pay about $250 to $500 a month to gain access to the club, which includes a child care center, meditation space and shelves lined with books on feminism.

The Jane Club sponsors an occasional book club. The night the Iowa caucus results were supposed to come in, a group of about a dozen women in their 30s and 40s gathered to discuss “Good and Mad,” a book examining women’s anger by the journalist Rebecca Traister. They went over the recent events covered in the book — Hillary Clinton’s loss, the gains from the #MeToo movement and the 2018 midterm elections. When they floated back to the current state of political affairs, they mostly sounded pessimistic.

Before the conversation began, June Diane Raphael, an actress and one of the founders of the Jane Club, was pouring herself a glass of wine in the kitchen.

“I’m feeling really anxious, the same kind of anxiety as I had in 2016,” she said. “We’ve been in mourning all that time and now we’re starting over again. I might feel different if it were Warren doing well — maybe then I’d be more hopeful.”

Like most of the other women in the group, Ms. Raphael had participated in the Women’s March in 2017 and donated to women running for Congress in 2018. She had felt her enthusiasm flag more recently. She was still angry, but she was also weary.

“We can’t let the world get away with defeating us into exhaustion,” she said.

At the end of the December Democratic debate in Los Angeles, the moderators asked each of the candidates to either offer a gift or ask for forgiveness. All the men spoke of their gifts. Both Ms. Warren and Senator Amy Klobuchar of Minnesota — the only other woman onstage — chose the other option.

“I will ask for forgiveness,” Ms. Warren began. “I know that sometimes I get really worked up. And sometimes I get a little hot. I don’t really mean to,” she said, adding that she was motivated by the pain she often heard from voters.