A 16-year-old Guatemalan migrant died while in U.S. government custody on Tuesday, the latest in a series of child deaths as Central Americans continue flooding across the southern border.

No health concerns were observed by Customs and Border Protection personnel when they picked him up, and the child did not report any health problems when he was transferred to a shelter on April 20 operated by the Department of Health and Human Services, according to a statement from the department.

By the next day, the boy "became noticeably ill including fever, chills and a headache," according to the statement. That started a chaotic week when the boy was taken to three different hospitals, including two emergency room visits and a stay in the intensive care unit of a children's hospital in Texas.

The department said the boy's brother and Guatemalan consular officials were allowed to visit the boy in the hospital. His family in Guatemala was also given "frequent updates" directly from hospital staff.

But after several days in the ICU, the boy died on Tuesday, according to Health and Human Services.

The cause of death of the boy, who was not identified, is under investigation, and the department is initiating a "full review" of the death. But the case may restart debates in Washington over the Trump administration's treatment of the record number of families and children pouring across the southern border.

Eight-year-old Felipe Gomez Alonzo from Guatemala died in a New Mexico hospital on Christmas Eve after being held at a Border Patrol facility. Earlier that month, Jakelin Caal Maquin, a 7-year-old from from Guatemala, died in a Texas hospital after being held at a Border Patrol facility.

Those deaths prompted the Department of Homeland Security to expand medical screenings of migrant children held in its custody. And on Wednesday, the White House requested emergency funding from Congress to deal with the "crisis" at the border, including $3.3 billion for humanitarian assistance.

But the administration has spent the past year focusing more on the law enforcement threat of arriving migrants than on processing their cases or expanding their ability to safely house them.

Read more stories:Download the USA TODAY app