Joel Matip is set to miss Liverpool's Premier League clash with Southampton at Anfield on Saturday.

The former Schalke defender has been hampered by a thigh problem this week and is unlikely to be risked against Saints.

It means Dejan Lovren is expected to start for the Reds for the first time since his nightmare afternoon in last month's defeat to Tottenham at Wembley.

Matip's absence is likely to see Lovren play against his former club alongside Ragnar Klavan at centre-back.

It's a blow for Jurgen Klopp after the club's injury situation had cleared up considerably this week.

Jordan Henderson, Adam Lallana and Sadio Mane have all returned to full training and are fit to face Southampton.

Philippe Coutinho is also poised for his Liverpool comeback after missing the previous three matches with a groin injury.