Ventura, California(CNN) Tens of thousands fled their homes Tuesday as several incredibly fast-moving brush fires pushed by howling Santa Ana winds scorched parts of Southern California.

"Fires are breaking out across the so. Cal. Region... Be fire safe. Firefighters are working very hard to minimize damage to property. Evacuations are taking place in many places in Southern California," the Ventura County Fire Department tweeted.

Unpredictable winds and extremely dry brush, victim of little rainfall over the past three months, fueled at least five blazes.

In Los Angeles, at least 500 firefighters watched a fire go from 4,000 acres to 11,000 in a matter of hours.

"We simply don't know what this fire will do," Mayor Eric Garcetti said.

To the west, the biggest blaze had zero containment and it had grown to 50,500 acres -- about 78 square miles -- in just 19 hours.

Some homes were ablaze in the northernm part of Ventura, a city of more than 100,000 on the Pacific coast. More than a quarter of the city's residents had been told to get out.

Wildfires spread in Southern California Flames from a back-firing operation rise behind a home off Ladera Lane near Bella Vista Drive in Santa Barbara, California, on Thursday, December 14. Powerful Santa Ana winds and extremely dry conditions are fueling wildfires in Southern California in what has been a devastating year for such natural disasters in the state. Fire, smoke and ash from the Thomas Fire blanket Santa Barbara on Wednesday, December 13. A smoke-filled sky filters sunlight to orange around a surfer as the Thomas Fire continues to grow and threaten communities from Carpinteria to Santa Barbara on Tuesday, December 12, in Carpinteria, California. People watch as firefighters battle flames in Carpinteria, California, on Monday, December 11. As smoke obscures the sun, a Coulson C-130 air tanker turns to make a drop on a Carpinteria hillside on December 11. As the Thomas Fire burns in the background, Dan Bellaart and his wife, Mary McEwen, comfort each other in their backyard in Montecito, California, on December 11. The Thomas Fire burns in the mountains near Carpinteria on Sunday, December 10. Firefighters battle a wildfire as it advances on homes in Carpinteria on December 10. A cloud of smoke overshadows downtown Ventura, California, on December 10. Horses are evacuated from the Laughing Dog Ranch as smoke from the Thomas Fire descends on the area in Ojai, California, on Saturday, December 9. The shell of a burnt-out bus is seen after fire swept through residential neighborhoods near Ojai on Friday, December 8. Flames rise as a fire approaches the Lake Casitas area of Ojai on December 8. A burnt Mercedes is seen after the Skirball Fire swept through the Los Angeles neighborhood of Bel-Air on Thursday, December 7. Palm trees sway in a gust of wind as a firefighter carries a hose in Ventura on December 7. Residents watch the Thomas Fire burn a hillside above La Conchita, California, on December 7. Fires surround a hilltop mansion in Los Angeles on Wednesday, December 6. "Daddy, the home is gone," Amanda Lewis tells her family on December 6. The Thomas Fire raged through her parents' foothill neighborhood in Ventura. Smoke rises across Southern California in this image taken from the International Space Station on December 6. A Los Angeles County Fire Department helicopter makes a water drop on flames after the Skirball Fire swept through Bel-Air on December 6. Flames from the Thomas Fire burn above a truck north of Ventura on December 6. Joyce George, right, comforts neighbor Dawn Reily on December 6. Reily's Ventura home was destroyed by fire. Flames consume vehicles in Ventura on Tuesday, December 5. Smoke billows from a burning house in Los Angeles as the Creek Fire moves through the area on December 5. A man watches as a wildfire burns in Ventura on December 5. The Creek Fire burns on a hillside in the Shadow Hills neighborhood of Los Angeles on December 5. A firefighter battles a blaze in the Lake View Terrace area of Los Angeles on December 5. Antoine Hanna comforts his wife, Tammy, after firefighters saved their home in Ventura on December 5. This Ventura apartment complex, seen on December 5, was destroyed by fire. A firefighter sprays water at a burning house in the Lake View Terrace area of Los Angeles on December 5. Palm trees burn in Ventura on December 5. Ventura County firefighter Aaron Cohen rests on December 5. A man prepares to evacuate his house in Santa Paula, California, on December 5. A man tries to catch a horse that got loose in the Lake View Terrace area of Los Angeles on December 5. Shrubs burn near a home in Ventura on December 5. James and Josie Ralstin carry belongings retrieved from their home in Ventura on December 5. Firefighters work to put out a blaze engulfing homes in Ventura on December 5. The Thomas Fire burns along a hillside near Santa Paula on December 5.

The fire -- the largest of several wind-driven blazes in Southern California -- forced sheriff's deputies to knock on doors to warn residents to evacuate Monday night. About 150 buildings, including homes and an evacuated Ventura hospital, have been destroyed.

On Ventura's northern edge, at least 10 homes and many trees were burning in one neighborhood, sending thick smoke and dangerous embers into the gusty air.

Live updates: Wildfires spread in Southern California

An evacuee, Catherine Wastweet, stood on a street Tuesday morning and looked up to the foothills where her neighborhood was aflame.

"We live up there ... but we just don't know whether our house is burned down or not, because we can't even see through all of the smoke," she said.

A NASA image from space shows the Southern California wildfires.

Latest developments

• Mass exodus: Garcetti said about 150,000 people in Los Angeles were affected by evacuation orders for the Creek fire near Sylmar and Lake View Terrace.

• Please go: About 38,000 people were under mandatory evacuation in Ventura County as fire officials warned the powerful winds could push flames farther into the city of Ventura. One official said, "It's important that you heed the advice to evacuate, please."

• Responders hurt: Two firefighters who were injured at the site of the Creek fire were "doing fine," Los Angeles County Fire Chief Daryl Osby said. No civilians have been hurt, he said.

• Blazing fast: The large fire, known as the Thomas fire, was burning at nearly an acre per second. At that speed, it would have covered Manhattan's Central Park in about 15 minutes.

• Gutted by flames: Vista del Mar Hospital, an 82-bed mental health facility in northwestern Ventura, was fully evacuated two hours before it burned, county fire engineer Richard Macklin said.

• State response: Gov. Jerry Brown declared an emergency for Ventura County, freeing state resources such as the National Guard to support response efforts.

Smoke rises behind a leveled apartment complex as a wildfire burns in Ventura on Tuesday.

• Other fires: The Rye fire near Santa Clarita in Los Angeles County had grown to about 5,000 acres. In San Bernardino County, a 100-acre and a 50-acre fire sprang up.

Santa Ana winds and dry conditions

The Thomas fire started north of Santa Paula on Monday evening and jumped to thousands of acres with startling speed as Santa Ana winds, blowing as fast as 50 mph, carried its embers. It engulfed dry chaparral and climbed through steep terrain.

Satellite images show how fast it lit up neighborhoods at night.

The winds were part of the season's "strongest and longest" Santa Ana event. The Santa Anas are strong, dry winds that high-pressure systems push from east to west, from the mountains and desert areas down into the Los Angeles area.

Wind gusts reached between 35 to 50 mph on Tuesday, with relative humidity at 3 to 10%, NWS incident meterologist Rich Thompson said. The winds were expected to decrease Tuesday night, but are expected to kick back up late Wednesday into Thursday. A red-flag warning is in effect until 8 p.m. PT on Friday.

"We expect to be out here all week fighting and containing this fire," Garcetti, the Los Angeles mayor, said of the Creek fire.

Dry conditions won't help. The county is in a period of moderate drought, the US Drought Monitor says.

'I saw a skyscraper inferno of smoke'

Erik Nasarenko, a Ventura city councilman and former mayor, said he was at a council meeting Monday evening when the city manager told him his neighborhood was being evacuated.

"I left the meeting, raced home, and I saw a skyscraper inferno of smoke," Nasarenko said. After collecting important documents from his home, he was about to pick up family photo albums when approaching flames made him reconsider.

"I saw the orange glow, and I just said, 'Let's go.' " Nasarenko said he, his wife and two children drove to his parents' home near San Fernando.

He doesn't yet know the fate of his house, but he said neighbors told him they saw nearby structures on fire.

A knock on the door

Orange flames glow threateningly close to a Ventura neighborhood in video recorded by Eric Rosenberg. He and his wife were alerted to the fire around 12:30 a.m. when a neighbor knocked on his door.

"(The) power was out and (my) phone's internet was out," he said. "I texted a friend a mile or so away who gave me more info."

"We had packed the car at about 1 a.m. and left right away when the police said it was time to go" three hours later, he said.

Rosenberg and his wife are currently at his parents'-in-law home in Carpinteria, about 25 minutes from their home. "We can see the billowing smoke clouds in the distance," Rosenberg said.

Thousands without power

The fire burned down power lines, at one point leaving more than 260,000 homes and businesses without power in Ventura County and neighboring Santa Barbara County, said Susan Cox, a spokeswoman for Southern California Edison.

By early Tuesday, power had been restored to all but 20,000 customers -- but more outages were possible because flames were burning along power transmission paths, Cox said.

As the fire spread, the nearby hills glowed bright orange while residents in Santa Paula threw belongings into cars as they began to evacuate, according to video footage from CNN affiliates.

About 1,000 firefighters were battling the blaze or heading to the area to help, said county fire engineer Macklin.

"I've never seen a fire burn down so many structures so fast in my (30-year) career," Macklin said.

One airborne firefighter tweeted dramatic video of the Creek Fire, showing choking smoke and at least one tall tree engulfed in flames.

"Unbelievable conditions," Michael Dubron wrote.

In some areas, the winds made it impossible for firefighters to use airplanes to attack the fire, officials said.