Domain Road will close for five years to make way for the Melbourne Metro Tunnel, triggering the need for a new tram route, the 58, between South Yarra and the CBD.

Two extra tram stops and four kilometres of rail have been built along Toorak Road West during a school holiday "construction blitz", said acting transport minister John Eren.

Domain Road closed on Wednesday between St Kilda Road and the western edge of Edmund Herring Oval to allow the works on the new station to proceed.

The 58 tram will run along the new route while Domain Road remains closed.