There are PLENTY of non-pony OC's and personas out there in the FiM fandom. Changelings, Diamond Dogs, dragons, deers, Yaks and so on. But humanoid? Well, human itself we don't exactly see besides comics or fics with story-lines about being human in Equestria, or as a representation of a person instead of making a ponysona.



But you can find general humanoid creatures in plenty. Humanoid: Something that has an appearance resembling a human being. That be standing on two feet, possessing two arms with functioning hands, and generally human features. Minotaurs are considered humanoid, so are Diamond Dogs for standing on two feet and using hands. Discord is humanoid in that matter too. Can go humanoid with Tirek too by focusing on the upper part and forgetting he has four hooves instead of two feet. Gryphons can be discussed though, as they are still walk on all four like animals, only possessing hands with their front paws being bird talons, but they can stand up on their hind legs and move around like a human if choosing to. It generally depends on their depiction but often mostly not considered humanoid.