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Republican presidential candidate Donald Trump called on President Barack Obama to resign over his reponse to the Orlando massacre.

Trump his out at Obama because he did not say the words “radical Islam” in his statement on the shooting, in which 50 people were killed .

“Because our leaders are weak, I said this was going to happen - and it is only going to get worse,” Trump said in a statement.

“I am trying to save lives and prevent the next terrorist attack. We can’t afford to be politically correct any more.”

In his official statement from the White House, Obama condemned the shootings as “an act of terror and an act of hate”.

(Image: REX/Shutterstock)

“We are still learning all the facts,” he said. “This is an open investigation. We’ve reached no definitive judgment on the precise motivations of the killer.

“I’ve directed that we must spare no effort to determine what – if any – inspiration or association this killer may have had with terrorist groups. What is clear is that he was a person filled with hatred.”

He added: “We are united in grief, in outrage and resolve to defend our people".

Read more:First picture of Orlando gunman who killed 50 people

Obama had previously campaigned to tighten the country’s gun laws and said the tragedy showed how easy it was for a person to acquire a weapon.

“We have to decide if that's the kind of country we want to be,” he said.

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Trump’s campaign said he will address the attacks in a speech he already had scheduled to deliver on Monday addressing national security and responding to criticism from Democratic rival Hillary Clinton.

He also repeated his call for a temporary ban on Muslims entering the United States, adding he was “right on radical Islamic terrorism”.

"What has happened in Orlando is just the beginning. Our leadership is weak and ineffective. I called it and asked for the ban. Must be tough," Trump wrote on Twitter.