Arking D.E.

Krebsova A.

Macek Sr., M.

Macek Jr., M.

Arking A.

Mian I.S.

Fried L.

Hamosh A.

Dey S.

McIntosh I.

Dietz H.C. Association of human aging with a functional variant of klotho. Proc. Natl. Acad. Sci. USA. 99 : 856-861 View in Article Scopus (323)

PubMed

Crossref

Google Scholar

Arking D.E.

Atzmon G.

Arking A.

Barzilai N.

Dietz H.C. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ. Res. 96 : 412-418 View in Article Scopus (203)

PubMed

Crossref

Google Scholar

Brigman J.L.

Wright T.

Talani G.

Prasad-Mulcare S.

Jinde S.

Seabold G.K.

Mathur P.

Davis M.I.

Bock R.

Gustin R.M.

et al. Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning. J. Neurosci. 30 : 4590-4600 View in Article Scopus (209)

PubMed

Crossref

Google Scholar

Cao X.

Cui Z.

Feng R.

Tang Y.P.

Qin Z.

Mei B.

Tsien J.Z. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Eur. J. Neurosci. 25 : 1815-1822 View in Article Scopus (125)

PubMed

Crossref

Google Scholar

Château M.T.

Araiz C.

Descamps S.

Galas S. Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans. Aging (Albany, N.Y.). 2 : 567-581 View in Article PubMed

Google Scholar

Chen C.D.

Podvin S.

Gillespie E.

Leeman S.E.

Abraham C.R. Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc. Natl. Acad. Sci. USA. 104 : 19796-19801 View in Article Scopus (338)

PubMed

Crossref

Google Scholar

Chen C.D.

Sloane J.A.

Li H.

Aytan N.

Giannaris E.L.

Zeldich E.

Hinman J.D.

Dedeoglu A.

Rosene D.L.

Bansal R.

et al. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS. J. Neurosci. 33 : 1927-1939 View in Article Scopus (90)

PubMed

Crossref

Google Scholar

Cissé M.

Halabisky B.

Harris J.A.

Devidze N.

Dubal D.B.

Sun B.

Orr A.

Lotz G.

Kim D.H.

Hamto P.

et al. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature. 469 : 47-52 View in Article Scopus (283)

PubMed

Crossref

Google Scholar

Deary I.J.

Harris S.E.

Fox H.C.

Hayward C.

Wright A.F.

Starr J.M.

Whalley L.J. KLOTHO genotype and cognitive ability in childhood and old age in the same individuals. Neurosci. Lett. 378 : 22-27 View in Article Scopus (65)

PubMed

Crossref

Google Scholar

Duce J.A.

Podvin S.

Hollander W.

Kipling D.

Rosene D.L.

Abraham C.R. Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia. 56 : 106-117 View in Article Scopus (82)

PubMed

Crossref

Google Scholar

Henley J.M.

Wilkinson K.A. AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive aging. Dialogues Clin. Neurosci. 15 : 11-27 View in Article PubMed

Google Scholar

Invidia L.

Salvioli S.

Altilia S.

Pierini M.

Panourgia M.P.

Monti D.

De Rango F.

Passarino G.

Franceschi C. The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect. Biogerontology. 11 : 67-73 View in Article Scopus (57)

PubMed

Crossref

Google Scholar

King G.D.

Chen C.

Huang M.M.

Zeldich E.

Brazee P.L.

Schuman E.R.

Robin M.

Cuny G.D.

Glicksman M.A.

Abraham C.R. Identification of novel small molecules that elevate Klotho expression. Biochem. J. 441 : 453-461 View in Article Scopus (34)

PubMed

Crossref

Google Scholar

Kojima N.

Sakamoto T.

Endo S.

Niki H. Impairment of conditioned freezing to tone, but not to context, in Fyn-transgenic mice: relationship to NMDA receptor subunit 2B function. Eur. J. Neurosci. 21 : 1359-1369 View in Article Scopus (23)

PubMed

Crossref

Google Scholar

Kuro-o M.

Matsumura Y.

Aizawa H.

Kawaguchi H.

Suga T.

Utsugi T.

Ohyama Y.

Kurabayashi M.

Kaname T.

Kume E.

et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 390 : 45-51 View in Article Scopus (2275)

PubMed

Crossref

Google Scholar

Kurosu H.

Yamamoto M.

Clark J.D.

Pastor J.V.

Nandi A.

Gurnani P.

McGuinness O.P.

Chikuda H.

Yamaguchi M.

Kawaguchi H.

et al. Suppression of aging in mice by the hormone Klotho. Science. 309 : 1829-1833 View in Article Scopus (1124)

PubMed

Crossref

Google Scholar

Li S.

Jin M.

Koeglsperger T.

Shepardson N.E.

Shankar G.M.

Selkoe D.J. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. J. Neurosci. 31 : 6627-6638 View in Article Scopus (372)

PubMed

Crossref

Google Scholar

Liu L.

Wong T.P.

Pozza M.F.

Lingenhoehl K.

Wang Y.

Sheng M.

Auberson Y.P.

Wang Y.T. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science. 304 : 1021-1024 View in Article Scopus (824)

PubMed

Crossref

Google Scholar

Liu H.

Fergusson M.M.

Castilho R.M.

Liu J.

Cao L.

Chen J.

Malide D.

Rovira I.I.

Schimel D.

Kuo C.J.

et al. Augmented Wnt signaling in a mammalian model of accelerated aging. Science. 317 : 803-806 View in Article Scopus (514)

PubMed

Crossref

Google Scholar

Luciano M.

Hansell N.K.

Lahti J.

Davies G.

Medland S.E.

Räikkönen K.

Tenesa A.

Widen E.

McGhee K.A.

Palotie A.

et al. Whole genome association scan for genetic polymorphisms influencing information processing speed. Biol. Psychol. 86 : 193-202 View in Article Scopus (55)

PubMed

Crossref

Google Scholar

Magnusson K.R.

Brim B.L.

Das S.R. Selective vulnerabilities of N-methyl-D-aspartate (NMDA) receptors during brain aging. Front. Aging Neurosci. 2 : 11 View in Article PubMed

Google Scholar

Mathur P.

Graybeal C.

Feyder M.

Davis M.I.

Holmes A. Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing. Pharmacol. Biochem. Behav. 91 : 453-460 View in Article Scopus (27)

PubMed

Crossref

Google Scholar

Nagai T.

Yamada K.

Kim H.C.

Kim Y.S.

Noda Y.

Imura A.

Nabeshima Y.

Nabeshima T. Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J. 17 : 50-52 View in Article PubMed

Google Scholar

Nguyen P.V.

Kandel E.R. A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices. J. Neurosci. 16 : 3189-3198 View in Article PubMed

Google Scholar

Palop J.J.

Jones B.

Kekonius L.

Chin J.

Yu G.-Q.

Raber J.

Masliah E.

Mucke L. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer’s disease-related cognitive deficits. Proc. Natl. Acad. Sci. USA. 100 : 9572-9577 View in Article Scopus (301)

PubMed

Crossref

Google Scholar

Piggott M.A.

Perry E.K.

Perry R.H.

Court J.A. [3H]MK-801 binding to the NMDA receptor complex, and its modulation in human frontal cortex during development and aging. Brain Res. 588 : 277-286 View in Article Scopus (74)

PubMed

Crossref

Google Scholar

Seshadri S.

DeStefano A.L.

Au R.

Massaro J.M.

Beiser A.S.

Kelly-Hayes M.

Kase C.S.

D’Agostino Sr., R.B.

Decarli C.

Atwood L.D.

Wolf P.A. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. BMC Med. Genet. 8 : S15 View in Article Scopus (153)

PubMed

Crossref

Google Scholar

Shiozaki M.

Yoshimura K.

Shibata M.

Koike M.

Matsuura N.

Uchiyama Y.

Gotow T. Morphological and biochemical signs of age-related neurodegenerative changes in klotho mutant mice. Neuroscience. 152 : 924-941 View in Article Scopus (75)

PubMed

Crossref

Google Scholar

Tucker Zhou T.B.

King G.D.

Chen C.

Abraham C.R. Biochemical and functional characterization of the klotho-VS polymorphism implicated in aging and disease risk. J. Biol. Chem. 288 : 36302-36311 View in Article Scopus (23)

PubMed

Crossref

Google Scholar

Urakawa I.

Yamazaki Y.

Shimada T.

Iijima K.

Hasegawa H.

Okawa K.

Fujita T.

Fukumoto S.

Yamashita T. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature. 444 : 770-774 View in Article Scopus (1200)

PubMed

Crossref

Google Scholar

Wang H.

Stradtman 3rd, G.G.

Wang X.J.

Gao W.J. A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex. Proc. Natl. Acad. Sci. USA. 105 : 16791-16796 View in Article Scopus (127)

PubMed

Crossref

Google Scholar

Wang D.

Cui Z.

Zeng Q.

Kuang H.

Wang L.P.

Tsien J.Z.

Cao X. Genetic enhancement of memory and long-term potentiation but not CA1 long-term depression in NR2B transgenic rats. PLoS One. 4 : e7486 View in Article Scopus (93)

PubMed

Crossref

Google Scholar

Yaffe K.

Cauley J.

Sands L.

Browner W. Apolipoprotein E phenotype and cognitive decline in a prospective study of elderly community women. Arch. Neurol. 54 : 1110-1114 View in Article Scopus (131)

PubMed

Crossref

Google Scholar

Yamazaki Y.

Imura A.

Urakawa I.

Shimada T.

Murakami J.

Aono Y.

Hasegawa H.

Yamashita T.

Nakatani K.

Saito Y.

et al. Establishment of sandwich ELISA for soluble alpha-Klotho measurement: age-dependent change of soluble alpha-Klotho levels in healthy subjects. Biochem. Biophys. Res. Commun. 398 : 513-518 View in Article Scopus (225)

PubMed

Crossref

Google Scholar

Yang K.

Trepanier C.

Sidhu B.

Xie Y.F.

Li H.

Lei G.

Salter M.W.

Orser B.A.

Nakazawa T.

Yamamoto T.

et al. Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases. EMBO J. 31 : 805-816 View in Article Scopus (53)

PubMed

Crossref

Google Scholar