To no surprise, The Orville uses a uses a 75-piece orchestra in its musical production with praiseworthy composers such as John Debney, Joel McNeely, Andrew Cottee, and Bruce Broughton. In a 2017 Forbes interview by Erik Kain (Interview: Seth MacFarlane On The Orville's Unique Tone, 'Star Trek' Roots), Seth MacFarlane stated "We score it like a movie,...I was thrilled with how many people caught that in the pilot on Twitter, so we get a lot of comments about the score, which is always very gratifying. We really put as much into that as we do into the effects."

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La-La records released The Soundtrack to Season 1 in 2019 in vinyl, but now available as a CD.