Harry Kane is expected to be out for up to three months with his latest ankle injury.

The ligament damage means that he will not only miss the rest of Tottenham Hotspur’s season but will not lead England at June’s Uefa Nations League final in Portugal which will be a huge blow to Gareth Southgate.

England’s first fixture takes place against Holland on June 6 and the manager will be desperate to have Kane there.

Kane suffered what Spurs called a “significant lateral ligament” injury to his left ankle during the Champions League quarter-final first-leg win over Manchester City at home on Tuesday.

The injury was sustained as Kane tackled City’s Fabian Delph by the touchline in the second-half with the striker immediately limping off in pain and not even attempting to continue.