Beaune, France

Within its ramparts and narrow cobblestone streets, Beaune has one major priority: the production—and consumption—of wine. Dubbed the wine capital of Burgundy—itself one of the most famous viticulture regions in all of France—the small town has been obsessed with the drink since the Middle Ages, thanks in part to the lavish lifestyles of the Dukes of Burgundy. Today, it remains the region's center for wine trade and tourism. As you walk through town, undoubtedly in search of prestigious Pinot Noir-based vintages, stop at the Wine Museum, the Dukes' former residence, for a quick study in oenology, then enter the cellars at Marche aux Vins for a free tour and tasting. Across the way, the Hotel-Dieu, a medieval charity-hospital museum that hosts an annual wine auction every November, offers a sobering look into the lives of the sick and poor in the 15th century.

Uncork: Biodynamic wines at Joseph Drouhin, best tasted in the winery's historical Duke's cellar, built on top of 4th-century Roman fortifications.

Pair: In the snazzy, red-cloaked dining room at Loiseau des Vignes, opened in 2007 by Dominique Loiseau (wife of late chef Bernard Loiseau), choose from among 70 different wines by the glass to accompany the regional prix-fixe menu.