SANA, Yemen — Late last August, a 40-year-old cleric named Salem Ahmed bin Ali Jaber stood up to deliver a speech denouncing Al Qaeda in a village mosque in far eastern Yemen.

It was a brave gesture by a father of seven who commanded great respect in the community, and it did not go unnoticed. Two days later, three members of Al Qaeda came to the mosque in the tiny village of Khashamir after 9 p.m., saying they merely wanted to talk. Mr. Jaber agreed to meet them, bringing his cousin Waleed Abdullah, a police officer, for protection.

As the five men stood arguing by a cluster of palm trees, a volley of remotely operated American missiles shot down from the night sky and incinerated them all, along with a camel that was tied up nearby.

The killing of Mr. Jaber, just the kind of leader most crucial to American efforts to eradicate Al Qaeda, was a reminder of the inherent hazards of the quasi-secret campaign of targeted killings that the United States is waging against suspected militants not just in Yemen but also in Pakistan and Somalia. Individual strikes by the Predator and Reaper drones are almost never discussed publicly by Obama administration officials. But the clandestine war will receive a rare moment of public scrutiny on Thursday, when its chief architect, John O. Brennan, the White House counterterrorism adviser, faces a Senate confirmation hearing as President Obama’s nominee for C.I.A. director.