Embattled New York City mayoral hopeful Anthony Weiner is facing a chorus of calls to get out of the race, but vows to soldier on until the September primary.

This in spite of the fact that his poll numbers are down and the departure of his campaign manager over the weekend signaled more cause for alarm.

“At this point, it’s absurd. He is not going to be the next mayor of New York. He is wasting time and space,” Democratic strategist David Axelrod said.

“Americans believe in second chances, but not third chances ... It’s time for him to go away, and let New York have its mayor’s race,” he added.

Axelrod is not the only high-profile Democrat who's seen enough Anthony Weiner nude photos and sexting headlines to last a lifetime at this point.

Former White House press secretary Dee Dee Myers said Bill and Hillary Clinton - who Weiner's wife Huma Abedin is a longtime aide to - are also fed up.

“This isn’t a story that anybody, particularly the Clintons, are happy to see ... I think they as much as anyone would like to see this go away,” Myers said.

Rivals from the opposing party also want him out. Weiner’s longtime foe, U.S. Rep. Pete King (R-NY), said that he has a “pathological problem.”

“He should do himself and everybody a favor and step to the sidelines. He is not psychologically qualified to be mayor of the city of New York,” King said.

King had a problem with Weiner long before the first sexting scandal that derailed his Congressional career in 2011, but is even more incensed now.

Even Weiner's sexting partner is sick to her stomach.

Sydney Leathers made headlines last week when she was revealed as the other party in Weiner's latest nudie pic swaps, but has turned on him pretty harshly.

"He should pull out," she told TMZ, without irony.

Leathers has become an advocate, urging New Yorkers to vote for Christine Quinn, his openly gay opponent who also says Weiner is not qualified to be mayor.

“Has he disqualified himself? Yes. He disqualified himself, but not just because of these scandals,” Quinn said, blasting his lack of a legislative record.

“He was in Congress for 12 years. He passed one bill.”

But despite the growing criticism and the departure of his campaign manager, Danny Kedem, Weiner pressed on with campaign stops over the weekend.

"We’ve gotten more volunteers and more people coming over to help the campaign in the last several days than any time since the campaign started," he said.

Anthony Weiner: Should he drop out?