Joe Biden, the US Vice President who lost his son to brain cancer last year, will travel to Melbourne to tour a new billion-dollar cancer treatment and research centre.

He will also make a speech at a Boeing factory. The aircraft manufacturer's largest facility in Victoria is based at Port Melbourne, where wings are constructed.

Vice President Joe Biden is bound for Melbourne. Credit:AP

The AFL has also reported Mr Biden may attend the match between Carlton and West Coast at the MCG on Sunday.

Mr Biden will meet Prime Minister Malcolm Turnbull in Sydney on Monday, before delivering what is billed as a "major policy speech on the future of the US-Australia relationship".

The US views of the region will be hotly anticipated in the wake of the stinging rebuke of China's claims to the South China Sea by an international arbitration tribunal.

The White House confirmed Mr Biden will arrive on the weekend to highlight US cooperation with Australian researchers at the Victorian Comprehensive Cancer Centre.

Mr Biden's son Beau died in May 2015 after a battle with brain cancer, having also suffered a mild stroke in 2010. He was 46.