(Reuters) — The financial and political fallout from Britain’s vote to leave the European Union has added to a string of setbacks for President Barack Obama as he works to burnish his legacy before his presidency ends in January 2017.

The Brexit decision came after a deadlock in the U.S. Supreme Court on Thursday effectively ended Obama’s push to overhaul immigration rules, and the week after the worst mass shooting in modern U.S. history.

For Obama, the reversals heighten pressure on him and fellow Democrats to work harder for the Nov. 8 elections – particularly for the party’s presumptive presidential nominee, Hillary Clinton, who represents his best shot at making sure more of his policies are not rolled back.

Speaking at two fundraising events in Seattle on Friday night, at the end of an arduous day that saw global markets plunge after the Brexit vote, Obama acknowledged the shifting political winds four months from the vote.

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