General description

1α,25-Dihydroxyvitamin D 3 , also referred as calcitriol, is a calcitrophic hormone. It is the most biologically active metabolite of vitamin D produced in proximal tubular cells in the kidney.

Application

1α,25-Dihydroxyvitamin D 3 has been used to study its effect on transplantation success of human muscle precursor cells (hMPCs) in severe combined immunodeficient (SCID) mice in-vitro.

Packaging

1 mg in poly bottle

100 μg in poly bottle

Biochem/physiol Actions

1α,25-Dihydroxyvitamin D 3 modulates energy metabolism by facilitating various metabolic processes, such as Ca2+ signaling and modulation of glucocorticoids, by affecting adipocyte apoptosis and by regulating the expression and production of multiple cytokines. In addition, it also modulates phosphorus homeostasis through actions in the intestine, kidney and bone. 1α,25-Dihydroxyvitamin D 3 exhibits antiproliferative effects and is used as a potent therapeutic for human prostate cancer.

Biologically active form of vitamin D 3 in calcium absorption and deposition. 1α,25-Dihydroxyvitamin D 3 has widespread effects on cellular differentiation and proliferation, and can modulate immune responsiveness, and central nervous system function. Recent studies suggest that 1α,25-dihydroxyvitamin D 3 acts as a chemopreventive agent against several malignancies including cancers of the prostate and colon and shows synergy with other anticancer compounds.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.