One of the new shows in Amazon's pilot season is Budding Prospects, based on the 1990 novel of the same name by TC Boyle, and it centers on three guys from San Francisco who head north to grow marijuana in the early 1980's.

The book was mentioned by several commenters when SFist published this list of great SF-set novels two years back, and it's one of several shows Amazon is premiering, with the pilot available for viewing right now on Amazon Prime.

It's directed by Terry Zwigoff, the director of Ghost World and Bad Santa who's also an old friend of R. Crumb from living in SF back in the day  he also directed the 1994 documentary Crumb.

The synopsis:

In 1983, three hapless guys from San Francisco are lured from their sex and drugs lifestyle to the countryside to grow marijuana. They find themselves stuck in a run-down cabin in the middle of nowhere, with harsh and unfriendly growing conditions, nosy neighbors, dangerous locals, and menacing law enforcement.

Per the novel description, if you haven't read it:

All Felix Nasmyth and friends have to do is harvest a crop of Cannabis Sativa and half a million tax-free dollars will be theirs. But they haven't reckoned on nosy Northern California-style neighbors, torrential rain, demands of the flesh, and Felix's improbable new love, a wayward sculptress on whose behalf he undertakes a one-man vendetta against a drug-busting state trooper named Jerpbak. As their deal escalates through crises into nightmare, their dreams of easy money get nipped in the bud.