(CNN) A jury handed an unparalleled $2.055 billion verdict in favor of a couple in California who say their cancer was caused by long-term exposure to Monsanto's popular weed killer Roundup, according to the plaintiffs' attorneys.

The verdict in Oakland includes more than $55 million in compensatory damages to the couple and $2 billion in punitive damages, a statement said.

The verdict "is as clear of a statement as you can get that they need to change what they're doing," one of the plaintiffs' attorneys, Brent Wisner, told reporters Monday.

It follows several recent losses the company has faced in court concerning Roundup. Thousands of similar cases are pending at the federal or state level.

Bayer, the parent company of Monsanto, insists that glyphosate -- the key ingredient in Roundup -- is safe.