BEIJING — In another sign that China is aiming at Microsoft, the government warned the company on Monday not to interfere with its antitrust investigation, days after officials conducted surprise raids on four of the technology giant’s offices across the country.

The harsh warning, using terminology rarely seen in commercial cases and normally reserved for China’s most challenging political nemeses, like Japan and the Dalai Lama, signals how seriously Beijing is taking the inquiry at a time of rising tensions between China and the United States over spying and economic issues. The State Administration for Industry and Commerce issued a statement on its website “officially warning” Microsoft to obey Chinese law and “not to interfere with or hinder the investigation in any way.”

China has long maintained that the country must wean itself off foreign technology suppliers to strengthen its domestic industry and better protect its secrets from foreign governments. Also on Monday, Chinese regulators questioned Microsoft’s deputy general counsel, Mary Snapp.

Last week, the government agency announced that it was investigating Microsoft in response to complaints over the company’s use of bundling and verification codes in its Windows operating system and Office software, as well as for not disclosing information about its products.