Facing a significant revenue shortfall this year, BuzzFeed is laying off about 100 employees and reorganizing its advertising sales and business operations as it moves away from relying purely on native advertising.

BuzzFeed plans to reduce its U.S. staff by 8%, with all the cuts coming from the business and sales side of the organization, the company said Wednesday. Some editorial staffers and business-side employees in the U.K. will also be let go. BuzzFeed employs about 1,700 people world-wide.

The...