Jason Zuffranieri’s king-making “Jeopardy!” streak came to an abrupt end Thursday night after 19 consecutive victories.

The 43-year-old math teacher from Albuquerque, New Mexico — whose total payout of $532,496 makes him the third-highest regular-season winner in the history of the storied game show — lost in the final round after leading the entire game.

Gabe Brison-Trezise, a 24-year-old researcher from Washington, DC, unseated Zuffranieri by answering the Final Jeopardy clue — ” ‘The Eighth Wonder,’ by composer Alan John & librettist Dennis Watkins, is about this building that opened in 1973″ — correctly.

Zuffranieri entered Final Jeopardy with $21,000, while Brison-Trezise trailed with $11,200. DC-based producer Christine Ryan had racked up $9,000. Zuffranieri and Ryan issued incorrect responses, while Brison-Trezise wrote down “What is the Sydney Opera House?” and left the round with $22,400 to Zuffranieri’s $19,500.

Half a million in winnings is impressive, but Zuffranieri still trails two of the greats by massive sums. James Holzhauer, who captivated viewers with a stunning 32-game streak over the summer, took home $2,462,216 total. Meanwhile, Ken Jennings remains the winningest player in “Jeopardy!” history with $3,220,700 in his coffers from 74 consecutive regular games plus special tournaments.

Zuffranieri streak-ender Brison-Trezise is a 2016 graduate of Kenyon College and the son of a Dartmouth professor who has extensive quiz bowl experience, according to the Valley News, a local publication in New Hampshire.

Zuffranieri auditioned for the show eight times before making the cut on his ninth attempt. On Wednesday, Zuffranieri told The Post that he never saw himself as unbeatable.

“It’s quite shocking really, because those players all seemed invincible right up until they lost, and I have never felt anything at all like that about myself,” he wrote in an email. “It took quite a bit of good fortune to make it as far as I have and it wouldn’t have taken very much for this to have ended a long time ago. The numbers speak for themselves, but I (and others) would rank myself in with the luckiest players in the show’s history before I’d consider myself one of the greatest.”

Holzhauer will compete against 14 other winners in the 28th Tournament of Champions, which starts Nov. 6. While the 15 players for that special faceoff were announced earlier this year, host Alex Trebek said Zuffranieri will definitely come back to play in the next tournament, though a date hasn’t yet been announced.

Perhaps it’s not a coincidence that Zuffranieri lost on a Thursday. Five matches are taped in a single day in “Jeopardy!’s” Burbank, California, studios; ones that air Monday through Wednesday are filmed before a midday hiatus.

“The show’s contestant coordinators have a maxim: ‘Champions lose on Thursday’, and that held true today,” writes Andy Saunders of The Jeopardy Fan. “It’s because it’s the first game back after lunch, and there’s a chance for the champion to lose their mojo over the lunch break.”

Beloved “Jeopardy!” host Trebek returned to the air on Sept. 9 for the premiere of the show’s 36th season six months after being diagnosed with stage 4 pancreatic cancer and undergoing chemotherapy. Last week, the 79-year-old announced he will undergo another round of chemo.