alex3619 said: I have hypothesized that one possible mechanism for post viral (actually many pathogens that can infect the gut wall or liver) fatigue to turn to ME is a failure of LPS detox, resulting in prolonged LPS in the blood stream. Thats an emergency signal to the immune system, it goes nuts. Click to expand...

-Dr Cheney recently stated ME/CFS is indistinguishable from mould illness and that he and Dr Shoemaker routinely trade patients. From this I conclude that something as simple as mould CAN cause all our symptoms.

-Several credible CFS/Mould patients have relieved themselves of PEM through mould avoidance. Many of Shoemaker’s patients actually get well and rid themselves of this symptom too. If PEM is the cardinal symptom in ME/CFS doesn’t it stand to reason that much of the problem is mould or something acting on the immune system in a similar way?

-Shoemaker has written that CIRS (chronic inflammatory response syndrome) -which, again, is indistinguishable from ME/CFS- can also be caused by exposure to LPS.

-Studies consistently show evidence of an increase of LPS translocation in ME/CFS.

I believe something like this to be central for many of us as well. Considering the following points, I think it’s difficult to downplay the potential importance of this idea.