Isbell says that he loves John Prine’s “Hello in There” because it reminds him of the elders in his family and when his grandfather taught him how to play musical instruments. Music has the power to motivate and “remind people of all the things they have in common with each other,” he says. Isbell hopes that this song encourages listeners to reach out, connect to each other with empathy and raise awareness to push Alzheimer's research forward.