More than a hundred cities—containing millions of people—will have water demands outstripping surface water supplies by 2050, according to a new analysis of climate change impacts on water.

The global study cited many cities in the U.S.—including Los Angeles, San Diego, Santa Ana and Long Beach in California, and Phoenix, Arizona—as headed for worsening future water problems.

These water deficits—exacerbated by a changing climate, a growing population and urbanization— will spur conflict between cities and nearby farming areas and put pressure on already stressed groundwater supplies.

There are "two big climate change impacts relevant to drinking water quantity," said senior author of the study, Robert McDonald, lead scientist for the Global Cities program at The Nature Conservancy. "Timing of rainfall is changing … in general wet periods will get wetter, dry periods will get drier.

"The other is that, because it's hotter, evaporation from whole watersheds will go up a lot, even if there is the same amount of precipitation, cities will find reservoirs a lot lower."

Currently about 54 percent of the world's population lives in cities—which is "likely to grow to between 60 percent and 92 percent" over the next 80 years, according to the study published in Nature Sustainability journal.

"We're in the middle of the fastest urban growth in history, and it would be hard to build water supply systems for all those people anyway," McDonald said. "Climate change is making it harder."

Water demand in cities is estimated to increase by about 80 percent by 2050. Globally, surface water demand will surpass supply by about 366 billion gallons, leaving 233 million people in cities with potential shortages, meaning the cities would be reliant on storage to get people safe water.

"This clearly points out a very stressful challenge ahead for cities—for all water users," said Brian Richter, the president of Sustainable Waters, who was not involved in the current study.

Top 10 cities with a projected surface water deficit by 2050:

Los Angeles, California

Jaipur, India

Dar es Salaam, Tanzania

Dalian, China

San Diego, California

Karachi, Pakistan

Harbin, China

Phoenix, Arizona

Porto Alegre, Brazil

Monterrey, Mexico

The "United States shows a clear division between cities in the West that are vulnerable to a surface-water deficit and cities in the East that have little vulnerability," the authors wrote.

Researchers estimated future water demand and availability in 482 of the world's largest cities, which contain 736 million people.

Due largely to climate change impacts on water supplies and trends of turning natural areas to urban, they estimate 27 percent of the 416 cities that rely on surface water will have a water deficit three decades from now. In addition, 41 percent of all river basins are set to have conflict between urban water users and agricultural users.

"South Asia is a hotspot region where competition between urban and agricultural demand is generally highest," the authors wrote.

The study comes as the World Economic Forum released their 2018 Global Risks Report, which cited "water crises" as the fifth highest risk to the planet over the next decade. Failure to mitigate and adapt to climate change was fourth on the list.

The annual report points out that lack of water is strongly linked to other escalating challenges such as food insecurity, involuntary migration and struggling economies.

Water scarcity could cost some regions of the world—such as Central Africa, the Middle East, and East Asia— up to 6 percent of their GDP.