In the 1991 interview, he said: “If I’m on a roll, and I finish a script at 3:00, I’ll start another at 3:02.”

Image The director John Hughes in 1984. Credit... Associated Press

Mr. Hughes’ biggest success, in box-office terms, was the “Home Alone” series, of which he was the writer and a producer. The first film, released by 20th Century Fox in 1990, turned the simple tale of a young boy, played by Macaulay Culkin, who was forgotten by his vacationing family, into a monster hit. The film took in more than $285 million at the domestic box office and spawned two sequels.

He had a reputation for discovering and bringing out the best in young actors. In a statement on Thursday, Mr. Culkin said: “I was a fan of both his work and a fan of him as a person. The world has lost not only a quintessential filmmaker whose influence will be felt for generations, but a great and decent man.”

Mr. Hughes’s greatest professional effect came from a series of teen-oriented films he directed in the 1980s, beginning with “Sixteen Candles” in 1984. It was a whip-smart but tender look at coming of age, with Molly Ringwald as a girl whose 16th birthday is forgotten in the whirlwind of her sister’s wedding; it featured emerging actors like Anthony Michael Hall, John Cusack, Joan Cusack and Jami Gertz, among others.

“The Breakfast Club” followed in 1985, with “Weird Science,” immediately behind, in the same year. By then, the troupe of young actors who showed up in films by Mr. Hughes and others who worked in the same vein had expanded to include Emilio Estevez, Judd Nelson and Ally Sheedy; they were tagged “The Brat Pack.”