GAINESVILLE, Fla. -- Florida will be without four starters for this week's game against South Carolina, coach Jim McElwain confirmed on Monday.

Starting quarterback Luke Del Rio, who had a rough game against Arkansas, actually injured his throwing shoulder early in the second quarter of the game. He will miss this week's contest, with backup Austin Appleby proceeding as the starter this week in practice.

"Looking at myself in the mirror, we should have made a change at halftime," McElwain said, before later saying Del Rio will be "out for a while."

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McElwain reiterated that had he known the severity of Del Rio's injury during the game he would have made a change. Asked what the severity of the injury is and whether it could be season-ending, McElwain said he was unsure and that Del Rio is slated to undergo another MRI.

"I don't know that," he said. "It's bad, man. When you can't lift your duffel bag up, chances are something's hurt."

Along with Del Rio being out, starting linebacker Alex Anzalone underwent surgery to fix a broken arm on Monday and will miss the rest of the season. The Gators will also be without starting linebacker Jarrad Davis, who reinjured his left ankle against the Razorbacks.

Starting center Cameron Dillard will also miss the game with a left knee injury.

Meanwhile, a few others are in doubt for this week. McElwain said receiver Chris Thompson (hard hit on a kickoff return) and receiver Tyrie Cleveland (left leg injury) will be "highly questionable."

Former walk-on running back Mark Herndon will also miss the game, while defensive end CeCe Jefferson will be a game-time decision with a foot injury.

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Contact Thomas Goldkamp by 247Sports' personal messaging system or on Twitter at @ThomasGoldkamp.