Run away and never look back.

That was just one piece of advice friends offered a far north Queensland woman who found a "f---ing huge" python wrapped around her guest room on Monday morning.

The reportedly 5m, 40-kilogram monster, nicknamed Monty, had somehow managed to wind its way along the walls of Trina Hibberd's home in Mission Beach, south of Cairns.

Video posted to Facebook showed the immense reptile stretching around a corner, over a painting and on a hatstand in the corner of another room.