CREATING LIFE CREATING LIFE Experts expect an announcement within three to 10 years from someone in the now little-known field of "wet artificial life." "It's going to be a big deal and everybody's going to know about it," said Mark Bedau, chief operating officer of ProtoLife of Venice, Italy, one of those in the race. "We're talking about a technology that could change our world in pretty fundamental ways in fact, in ways that are impossible to predict." That first cell of synthetic life made from the basic chemicals in DNA may not seem like much to non-scientists. For one thing, you'll have to look in a microscope to see it. "Creating protocells has the potential to shed new life on our place in the universe," Bedau said. "This will remove one of the few fundamental mysteries about creation in the universe and our role." And several scientists believe man-made life forms will one day offer the potential for solving a variety of problems, from fighting diseases to locking up greenhouse gases to eating toxic waste. Bedau figures there are three major hurdles to creating synthetic life: A container, or membrane, for the cell to keep bad molecules out, allow good ones, and the ability to multiply. A genetic system that controls the functions of the cell, enabling it to reproduce and mutate in response to environmental changes. A metabolism that extracts raw materials from the environment as food and then changes it into energy. One of the leaders in the field, Jack Szostak at Harvard Medical School, predicts that within the next six months, scientists will report evidence that the first step creating a cell membrane is "not a big problem." Scientists are using fatty acids in that effort. Szostak is also optimistic about the next step getting nucleotides, the building blocks of DNA, to form a working genetic system. His idea is that once the container is made, if scientists add nucleotides in the right proportions, then Darwinian evolution could simply take over. "We aren't smart enough to design things, we just let evolution do the hard work and then we figure out what happened," Szostak said. In Gainesville, Fla., Steve Benner, a biological chemist at the Foundation for Applied Molecular Evolution is attacking that problem by going outside of natural genetics. Normal DNA consists of four bases adenine, cytosine, guanine and thymine (known as A,C,G,T) molecules that spell out the genetic code in pairs. Benner is trying to add eight new bases to the genetic alphabet. Bedau said there are legitimate worries about creating life that could "run amok," but there are ways of addressing it, and it will be a very long time before that is a problem. "When these things are created, they're going to be so weak, it'll be a huge achievement if you can keep them alive for an hour in the lab," he said. "But them getting out and taking over, never in our imagination could this happen." — Associated Press Digg



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Facebook WASHINGTON  Philosophers wrestling with the big questions of life are no longer alone. Now scientists are struggling to define life as they manipulate it, look for it on other planets, and even create it in test tubes. In June, researchers replaced the genetic identity of one bacterium with that of a second microbe. Other scientists are trying to build life from scratch. NASA scientists are searching for life in space but aren't sure what it will look like. And some futurists are pondering the prospect of robots becoming so human they might be considered a form of life. So as scientists push the bounds of biology, astronomy and robotics, a big question looms: What exactly is life? That question is bubbling up from recent advances in lab work. In suburban Washington this summer, prominent scientists at the J. Craig Venter Institute, who were key players in mapping the human genome, switched DNA from one bacterium into another, changing its genetic identity. That put the world on notice that man's ability to manipulate life is dancing around the point of creation. Now Venter is asking for a patent for a completely new bacteria that would be created by inserting genes into a hollowed-out cell of what once was a urinary tract bug. Venter doesn't view that as creating life, just "modifying life to come up with new life forms." At least half a dozen other research teams around the world are going farther, trying to create life out of chemicals, mimicking the beginnings of life on Earth. They're somewhere from three to 10 years from success, they figure. For them, and Venter, new man-made life forms mean new energy sources, environmental clean-up mechanisms and life-saving medicines. For others, such a breakthrough would mean understanding how life began on Earth by trying to recreate it. "We're all sort of thinking that the next origin of life will be in somebody's lab," said David Deamer, a University of California, Santa Cruz, biochemistry professor who is one of the leading experts trying to create life. But ask Deamer what life is, and he responds by saying it's best to describe it, not define it. Broadly put, scientists like Deamer say life requires a cell with genetic material and the ability to reproduce, turn food into energy, and to evolve through natural selection. But it's not that simple for others seeking a definition. At NASA's Astrobiology Institute in California, which studies extreme life here and the possibility of it elsewhere, it's far easier to say what life isn't, said institute director Carl Pilcher. "Right now we may not have the base of knowledge necessary to answer the question, but there are ways we are proceeding," he said. Last month, the National Academy of Sciences issued a "weird life" report cautioning NASA not to be so focused on water. It told the space agency that "as the search for life in the solar system expands, it is important to know what exactly to search for." That same report urged NASA to avoid being "fixated on carbon" when it looks for life even though carbon is often called the backbone of life on Earth. But if carbon isn't a requirement for life, how about silicon? In other words, what about machines? Ray Kurzweil, a renowned futurist who advises people such as Bill Gates, believes that by 2029 a machine will pass a prime test of artificial intelligence, offering the same kind of answers as a human. "The key issue as to whether or not a non-biological entity deserves rights really comes down to whether or not it's conscious," Kurzweil said. "Does it have feelings?" This isn't just a Kurzweil concept. "A monumental shift could occur if robots continue to be developed to the point where they can at some point reproduce, improve themselves or if they gain artificial intelligence," said a 2006 study commissioned by the British government's science office. That report compared the situation of robots to the emancipation of slaves. Many scientists familiar with these challenges of defining life say the answers won't be easy to find. "It's an important but ultimately frustrating question if one expects to come up with a nice clean shiny answer; it ain't going to happen," said Francis Collins, a prominent Christian scientist and director of the National Human Genome Research Institute. That talk about life is going to get uncomfortable as dreams of creation, from Frankenstein's monster on, get closer to reality, said University of Pennsylvania bioethicist Art Caplan. "This issue of 'what is life' has been at the core of biology for about 400 years," Caplan said. He said it leads to the more theological questions about whether life is special and whether we are special. Later this century, the definition of life will be at the heart of a political and societal debate as heated and divisive as abortion and embryonic stem cell research, Caplan predicts. Look for changes in religion, too. "As knowledge has (been) added, religions have adapted," Venter said. "I don't see why this is any different. We're pushing the frontiers of knowledge, understanding life on this planet." Venter dismisses suggestions that scientists are playing God as media sensationalism. And Collins, a scientist who talks at length about his faith, said he finds it interesting that the people who most often use the phrase "playing God" usually don't believe in God. "Playing God" is a secular, not religious, term, said Ted Peters, a professor at the Graduate Theological Union in Berkeley, Calif., and author of the book "Playing God." He said people who worry about that are really talking about tinkering with nature. "What Craig Venter is doing is an extremely complicated form of animal breeding," Peters said. "We're going to be changing the face of the planet no matter what. The question is do we want to do it responsibly or not?" C. Ben Mitchell, a bioethicist connected with Trinity University, an evangelical Christian college in Illinois, worries about entrusting such monumental developments with scientists. "Human history is enough; it is sufficient to remind us of the problem of hubris," Mitchell said. "It is at least a cautionary note, to caution us to be aware of unintended consequences." One of the men trying to make life from scratch, Mark Bedau, understands the worries. A philosophy professor from Reed College in Oregon, Bedau is also the chief operating officer of the synthetic biology firm ProtoLife in Venice, Italy. His team and others are trying to make single-cell organisms from chemical components, creating a genetic system that multiplies and a metabolism that takes in energy from the environment. Scientists say they are close to completing a key first step, creation of a vesicle, or container, for the cell. "We are doing things which were thought to be the province, in some quarters, of God — like making new forms of life," Bedau said in a phone interview from Venice. "Life is very powerful, and if we can get it to do what we want ... there are all kinds of good things that can be done. "Playing God is a good thing to do as long as you're doing it responsibly," he said. Copyright 2007 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed. Share this story: Digg del.icio.us Newsvine Reddit Facebook Enlarge By Paul Sakuma, AP In the experiment being outlined here by biochemistry professor David Deamer, scientists are "making the first pieces of life get together," he said. "The thing isn't alive yet, but it's a first step." Conversation guidelines: USA TODAY welcomes your thoughts, stories and information related to this article. Please stay on topic and be respectful of others. Keep the conversation appropriate for interested readers across the map.