A quarter-mile stretch of Greenwich Street disappeared from the map of Lower Manhattan in 1967, then from the face of New York on Sept. 11, 2001.

Now, it is reappearing as an important boulevard. Three of the four World Trade Center towers have their entrances on it, as does Santiago Calatrava’s Oculus, which is the Westfield shopping mall and the trade center transit hub. Mr. Calatrava’s St. Nicholas National Shrine is taking form in the elevated Liberty Park, reached by a broad staircase from Greenwich Street. Diners overlook the street from the recently opened Eataly.

The future of Greenwich Street includes a performing arts center in 2020, named for and bankrolled in part by the billionaire businessman Ronald O. Perelman. That will stand opposite 2 World Trade Center, to begin construction when the developer Larry A. Silverstein finds a major tenant. The Cortlandt Street subway station on the No. 1 line, damaged in the 2001 terrorist attack and closed since then, should reopen in two years, with entrances on Greenwich Street.