Pop music parodist “Weird Al” Yankovic has been tapped to voice the title role in Disney XD’s animated comedy series Milo Murphy’s Law (fka Mike Murphy’s Law), slated to premiere this fall. The voice cast also includes Christian Slater, Vanessa Williams, Sarah Chalke, Jemaine Clement, Sabrina Carpenter, Mekai Curtis, Chrissie Fit and Vincent Martella.

From Phineas And Ferb creators/executive producers Dan Povenmire and Jeff “Swampy” Marsh, Milo Murphy’s Law introduces Milo, the fictional great-great-great-great grandson of the Murphy’s Law namesake and the personification of Murphy’s Law, which states anything that can go wrong will go wrong. Suffering from Extreme Hereditary Murphy’s Law condition (EHML), Milo always looks to make the best of the cards he’s been dealt and his endless optimism and enthusiasm can turn any catastrophe into a wild adventure. Four-time Grammy winner Yankovic — who has a long string of parody hits including “Eat It,” “Fat,” “I Lost On Jeopardy” and “White & Nerdy” — also will sing the opening theme song and perform original songs as his Milo Murphy character throughout the series.

Carpenter (Girl Meets World) and Curtis (Kirby Buckets) co-star as Milo’s friends Melissa Chase and Zack Underwood. Povenmire and Marsh will also voice pistachio protectors Vinnie Dakota and Balthazar Cavendish.

The rest of the cast includes Slater (Mr. Robot) as Elliot Decker, a school crossing guard and Milo’s foe; Williams (Desperate Housewives) as Zack’s mom Eileen Underwood; Chalke (Scrubs) as science teacher Mrs. Murawski; Clement (Flight Of The Conchords) as popular television show character Dr. Zone; Mackenzie Phillips (One Day At A Time) as Principal Milder; Chrissie Fit (Teen Beach Movie) as classmate Amanda Lopez; Martella (Phineas And Ferb) as classmate Bradley Nicholson; Diedrich Bader (The Drew Carey Show) as Milo’s dad Martin Murphy; Pamela Adlon (Californication) as Milo’s mom Brigette Murphy; Kate Micucci (When In Rome) as Milo’s sister Sara Murphy; Dee Bradley Baker (Phineas And Ferb) as Milo’s dog Diogee; Gregory Michael Cipes (Ultimate Spider-Man) as classmate Mort Schaeffer; Michael Culross (Phineas And Ferb) as high school teacher Kyle Drako and Kevin Michael Richardson (The 7D) as Coach Nolan Mitchell.

Milo Murphy’s Law is produced by Disney Television Animation.