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Mod Organizer 2 should not be installed inside a system protected folder such as Programs Files (x86).Also avoid installing MO2 inside the Game folder as this causes problems with the vfs library.Mo2 is a 64bit application and as such it requires a 64bit operating system to run.Simplest for non-portable instanced installations, using the installer should be as simple as downloading and running the exe and specifying your install directory. It will download and install all necessary components required to run MO2.If you want to update an existing Mo2 install using the installer, simply select your current MO2 folder as the install location and the installer will take care of the rest without endangering your modded setup.As Windows tends to trust installer files better than manually extracted files, using the installer may provide a more problem-free experience.Often ideal for portable installations, simply extract MO2 to a new location for each game you wish to manage. It can still be used for instanced installs.Before unpacking the Mod Organizer 2 zip, make sure to open the properties and hit 'Unblock' if it shows up. If you don't do this then various libraries may fail to load or run when trying to use Mod Organizer. This can break certain installers or the virtualization system altogether.If you wish to update an existing Mo2 installation it is generally a good idea to make a clean upgrade following these instructions:1. Go to your MO2 installation directory, delete all directories and files EXCEPT for \downloads, \mods, \profiles, \overwrite, ModOrganizer.ini and categories.dat (leave those dirs and files, delete the rest).2. Extract the new version to this location.3. Start MO2.Mod Organizer 2 depends on the MSVC 2019 runtime library. You must download and install this for MO2 to work properly (in addition to the extra steps written above). Download and install the x64 versions of the 2019 redistributable:

If you are not on Win10 you might also need: https://support.microsoft.com/en-us/help/2999226/update-for-universal-c-runtime-in-windows

The installer version should automatically handle this step for you.Once installed, make sure the MO2 directory and/or files are excluded from any antivirus you may have installed. MO2's virtualization system hooks into the running applications and modifies system calls, and many antiviruses do not like this.GamerPoets covered this in this video of his official MO2 guide (that we highly recommend):