Arsenal will have to knock out the Champions League holders, Barcelona, to progress in the competition after drawing the Spanish champions in the last 16. Chelsea will face Paris Saint-Germain for a third consecutive season, while Manchester City play Dynamo Kyiv with the Ukrainian club forced to play their first leg behind closed doors due to racist behaviour from their fans.

It will be the third time Arsène Wenger’s side have met Barça in six years. In 2010 the Gunners were knocked out in the quarter-finals and in 2011 they were eliminated in the last 16.

Arsenal also lost the 2006 final to the Catalan club. They will host the first leg against Luis Enrique’s team on 23 February and the return match is at the Camp Nou three weeks later.

Lionel Messi has proved tricky opposition for Arsenal in the past, scoring four times against them in 2010, and the following year scoring twice in Barça’s 3-1 second-leg victory in Spain. Arsenal did, though, win the opening leg 2-1 in 2011, so Wenger can point to that experience as he prepares his side – although they have been eliminated at the first knockout stage for each of the last five seasons.

Barça are the opponents all of the clubs who were runners-up in their respective groups wanted to avoid. In PSG, Chelsea drew the toughest opponent possible to any of the group winners.

In the past two seasons away goals have been the vital factor when the clubs have met. In 2014 José Mourinho’s side knocked the French side out of the quarter-finals after losing 3-1 in Paris and winning the return game 2-0 in west London. Last season Laurent Blanc’s team advanced from the last 16 after a 2-2 draw at Stamford Bridge to progress on away goals, with the tie level on aggregate at 3-3.

Chelsea’s lacklustre Premier League title defence means they may be considered underdogs against PSG. Blanc’s side are the French champions and hold a 17-point lead over Angers and Monaco.

City were knocked out by Barcelona in the last 16 for the past two years but as Group D winners were assured of avoiding the Spanish side this time out – and Manuel Pellegrini may be pleased to be paired with Dynamo Kyiv, despite the long journey for the first leg.

The manager has built a formidable squad that has overcome a host of injures, including key players David Silva, Vincent Kompany and Sergio Agüero, and topped their Champions League group for the first time in their history.

City and their supporters, though, will be unhappy at Kyiv’s two-match stadium ban due to offences that included racism. It means their fans will not be able to attend – the second time in two seasons their travelling support have been unable to attend a high-profile game after CSKA Moscow were subject to a similar sanction last season for a group-stage game against Pellegrini’s side.

Four years ago Kyiv eliminated City from the Europa League, 2-1 on aggregate, and Txiki Begiristain, the director of football, said: “It’s never easy. They’ve shown they have a good side by beating Porto and drawing with Chelsea [in the group phase]. It’s going to be difficult for us, but the most important thing is that we show we’re improving in this competition and we’ll fight to get to the quarters.

“The weather sometimes doesn’t help, but we have to be ready. At least we play in England – it’s not the same, but it’s close. We’re ready to try and improve in this competition and grow.”

Champions League last-16 draw

Ghent v Wolfsburg

Roma v Real Madrid

Paris Saint-Germain v Chelsea

Arsenal v Barcelona

Juventus v Bayern Munich

PSV v Atlético Madrid

Benfica v Zenit St Petersburg

Dynimo Kyiv v Manchester City