One man was fatally shot and another killed in an automobile crash Wednesday afternoon after a gunman opened fire on vehicles in a Seattle neighborhood, authorities said.

Two people also were injured, including the driver of a Metro bus who was shot.

Deputy Police Chief Marc Garth Green told reporters: "We believe it's a random, senseless act. We're outraged at what this suspect did."

The chaotic scene unfolded in north Seattle just after 4 p.m. Police said in a statement that a man approached a female driver in the street and shot her.

Multiple victims in shooting incident in area of 120/Sandpoint. Please avoid area as officers investigate. —@SeattlePD

He then walked on and fired at a Metro bus, striking the driver, who was able to turn the vehicle around and drive away, authorities said.

The gunman then approached a second motorist and opened fire, killing a man in his 50s. After police arrived, the gunman fled in the victim's vehicle, police said. He then collided with another car nearby, killing the 70-year-old male driver.

The suspect was taken into custody after a brief standoff. He was transported to a hospital.

King County Metro said on Twitter that at 4:05 p.m. a bus operator on Metro Route 75 hit their emergency alarm and reported he had been shot. Preliminary information was that none of the 12 passengers on board was injured, the agency said.

The suspect was taken into custody after a brief standoff and transported to a hospital. (King 5 News)

The bus driver was hit in the torso, but able to walk to a gurney to be taken to a hospital by paramedics, said Kenneth Price, president of Amalgamated Transit Union Local 587.

Susan Gregg, spokeswoman at Harborview Medical Center, said her facility had received a man and woman in their 50s, and a 33-year-old man following the shooting and crash.

She said none suffered life-threatening injuries.