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The NFL announced Tuesday that Colts inside linebacker D’Qwell Jackson has been suspended for four games for violating the league’s performance-enhancing substance policy.

Jackson, 33, leads the Colts in tackles. He’s in his third year with the team after spending his first eight NFL seasons with the Browns.

Jackson previously has never missed a start with the Colts.

The four-game suspension means Jackson is done for the regular season and can return to the team should the Colts qualify for the playoffs. At 6-6, the Colts are in a three-way tie atop the AFC South the with the Texans and Titans.