Despite having just crushed the Knicks and Bobcats, Dwyane Wade was still hungry for blood this weekend ... destroying a group of innocent children in a pick-up basketball game ... and TMZ has the footage.

It all went down in NYC's Thompson Playground on Sunday ... the NBA All-Star had just wrapped up a sock-shopping session at The Sock Hop in Soho -- and decided to jump in on some kids' pick-up basketball game (wearing slacks, a dress shirt, and a tie).

Within seconds, it was total D-WADE DOMINATION ... and the kids LOVED it.