(Yes, technically it is more than 40 because I've added a couple extra)

1-The most clever people I know claim, in age, to have had only a handful of good ideas which must mean most things that seem like good ideas are either minor or wrong.

2-Most things are unknown. No one remembers that.

3-Most things are unknown.

4-Most people are happy to pretend to be stumbling toward the truth. It is enough to get by on, to feed oneself.

5-Most real challenges scientists have to deal with have nothing to do with science.

6-Half of the time the real practical scientific challenges can be solved with better policies and old science.

7-The other half of the time we are too stupid to even know which new science is useful to solve the challenges.

8-The worst thing is crappy basic science masquerading as application. The introduction to most papers is this worst thing and when it isn’t that is just because it has been supplanted by the last paragraph of the discussion.

9-If you assert that your field is relevant to some application, for example that biodiversity matters to ecosystem function, then be ready to prove it in practice.

10-Being married to an anthropologist who studied indigenous tribes is useful for considering academic departments.

11-If you find yourself in an argument in which you feel like a monkey grabbing for cake, go for a walk. Decide if you really want the cake. Decide also where you rank among the monkeys. Maybe go for a walk again. When you come back you will probably realize that the cake wasn’t so good to start with. Also one of your colleagues has probably since peed in the cake.

12-When you start as a faculty member the scene in Richard Russo’s book “Straight Man” where a faculty member is standing by the university pond saying something to the effect of “if I don’t get what I need in the department, I am going to kill this duck,” seems too outlandish even for a novel. The key to that sentence is “when you start…”

13-You will be told that the best solution is to do things the sensible way. But if you have the money it is way better to do things once, the very best way.

14-Help junior people, postdocs, and students who need help, ask for it, and seem likely to go on to great success (or to avert great failure). Hire people no one has given a chance. Give them one.

15-More scientists than you can imagine hope to someday win a Nobel Prize or do science that lasts forever and yields permanent and big truths. Sometimes you will hear them say these things, other times you can catch the scent of such ambition in the way they stand. A few achieve these desires and we laud them, write stories about their clever vision and determination. Most retire regretful, mumbling about how everyone misread their great works.

16-A great idea is like a rare bird. Sometimes it will pause before you. Take it in. Don’t try to call it by name. It is a thrill that might not come often. Even if the idea proves to be wrong, you won’t know it at first and so enjoy that thrill. Enjoy it as though, as a consequence of the idea, everything might change.

17-I won’t tell you the things I think make the most difference in science because I might still be wrong, though if I am right they are the things I wish someone would have told me when I was younger.

18-If you are very young 1800 seems like a long time ago. It was yesterday. And in 1800, we knew nothing about science. This is what they will say in 3014 about 2014 and in 4014 about 3014. When it comes to making sense of it all, we are four short steps ahead of the chimps and think we have it all figured out.

19-The reason that your parents don’t understand what you do is not because they “don’t get it,” it is because you “haven’t explained it,” or are studying something too obscure or boring.

20-I don’t know which ones, but I’ll bet that at least four of the organs in human bodies are still totally misunderstood.

21-When you go through a phase in which great ideas aren’t landing near you, review what we know. See what is missing, look for the things everyone assumes to be true and poke at them. If they seem soft, poke again. If someone says “that was figured out a hundred years ago” and you can’t find the old papers that figured it out, know you are on to something.

22-Some of the old, emeritus faculty that stalk your building were probably the most admired stars in some field several decades ago. A few will die when you aren’t watching and when they do you will realize they were people you should have asked a lot of questions. To note though…. Other emeritus faculty are just older versions of the same cake-grabbing young colleagues you see everyday.

23-Fruit flies and lab rats are fine if you remember that they are either a starting point for studying wild flies and rats or a really crappy model for the human body.

24-No one knows anything about the biology of wild fruit flies (people are starting to study wild mice)

25-Before you complain that funding is terrible, disappearing, the end of civil society, know the history of the funding agencies you are complaining about.

26-It isn’t pleasant, but part of your job is to think about what the incentives of other people (deans, chancellors, department heads, students, colleagues, etc… ) are. Even when no one is trying to trick you, everyone is trying to make his or her own life a little easier or more promising, as you should be as well.

27-Everyone tends to blame administrative problems on evil-doing. The far more common explanation is incompetence (My dean told me this).

28-If you get biologists outside looking at the things they love, they become different (better) people. Find excuses to get them outside.

29-You can learn from someone you don’t respect. You just feel bad about it later.

30-If you want an exciting job surround yourself with people who are smarter than you about some things if not most things. If you want a good life surround yourself with friends. If you are really lucky, you can do both.

31-In ancient Alexandria, the museum was the place where scholars gathered and were given food and drink to figure out the world. Think about this the next time you are at “Nacho Hut” complaining about your start-up package.

32-With time you will become an expert both in things that you want to be an expert in and those you don’t care to be one in. Hide the latter.

33-There are tens of thousands of great ideas in books and papers that no one has ever followed up on. If you are lucky, you will have six of your own great ideas. The odds favor reading old books and papers to improve your chances of working on something novel.

34-Know why you do science the way you do. It is probably because it is the way your advisor did it. If it is, explore other approaches or at the very least acknowledge that your choice of approaches is entirely contingent on your personal past.

35-Again, love the rare birds of what you do. It is OK to begrudge the sparrow of ordinary days, but your heart should skip when the mot-mot lands on your bench and flits its tail.

36-Remember to explain to the fruit fly people that the mot-mot is a kind of bird that flits its tail.

37-It doesn’t take many years before the students you taught in your first year come back to visit having established themselves as adults. Some great students go on to do great things. So do some terrible students.

38-A diversity of perspectives and people makes science better, in your lab, in your department, in your college. It allows you to see things you would miss, see them from perspectives you didn’t have and see questions you didn’t realize need answered.

39-It is easier to learn if you are around people who know different things than you know.

40-Faculty, even after having been faculty for a while, are still struggling with many of the same challenges they were dealing with when they were younger, such as what they want to do with their lives.

41-Maximize your efficiency, the number of interesting people you surround yourself with, and the number of times you smile. If the number of interesting people or number of smiles begin to decrease, figure out how to change it.

42-Seek mentors outside your department, university, and past training. As you get older, you will have fewer mentors and, ironically, may want mentoring more.

43-Listen to advice. Seek advice. If you ignore advice, choose to do so consciously and understand you have done so.

44-More senior faculty will assume you know what you are doing unless you ask for advice (which you should do) or begin to so obviously fail that it is too late.

45-The more interesting your ideas, the harder it will become to find anyone to tell whether they are brilliant or mad.