New Yorkers woke up Friday in the city that never sleeps to a fast-spreading coronavirus pandemic — and to an empty Times Square, no Broadway shows, no Knicks and Nets basketball, no concerts or other large gatherings and deserted office buildings.

Subways and commuter trains were running but with significantly fewer riders.

Aqueduct racetrack near JFK Airport told railbirds to stay home but was still planning to run a full card of horse races Friday afternoon.

Thursday's dizzying series of coronavirus-related shutdowns included some of New York City’s cultural jewels: the Metropolitan Opera, Metropolitan Museum of Art, the American Museum of Natural History and Carnegie Hall.

The shows affected by the Broadway shutdown included such big hits as "Hamilton" and "To Kill a Mockingbird."

Next week’s historic St. Patrick’s Day parade down Fifth Avenue, an event that attracts two million people each year, was also a casualty of the coronavirus.

At the same time, restaurants and bars were noticeably emptier. So too Manhattan’s bustling sidewalks.

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Many workers who fill Manhattan’s skyscrapers had been told to work from home Friday.

Colleges were holding classes online.

“People are scared to come outside,” said Justin Rahim, a tour guide at Manhattan’s Central Park, who said several of his pedicab drivers — reliant on tourists for their living — quit Thursday to drive for Uber's food delivery service. “It’s crazy. How am I going to survive this?”

The closures, cancelations and changes come as officials seek to contain the virus and mitigate the spread.

The number of confirmed coronavirus cases in New York City stayed at 95 as of Friday morning, officials said.

The total number of coronavirus cases in New York State was 328, second-most in the country behind Washington state which had 457 cases.

Nationally, there were at least 1,600 coronavirus cases in 47 states and DC.

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Mayor Bill de Blasio, while pointing out the outbreak could last six months or longer, counseled against giving up.

“The city has to keep going,” de Blasio told Fox 5 New York Friday morning. “We need people to have their livelihoods. We need folks to show up at work. We need our public servants to be where we need them to be to take care of folks -- hospitals, schools, first responders.”

De Blasio said he didn't want to close public schools because of their importance to the communities they serve.

An exception was New Dorp High School on Staten Island, which was ordered closed Friday after a student tested positive for the corona virus, according to the Staten Island Advance.

The total number of people with the virus in New York City wasn't known due to the relative scarcity of tests.

But for some, the danger is all too real.

On Tuesday, John Brennan, a New Jersey resident and a horse trainer at Yonkers Raceway, just north of the city, was killed by the virus.

Two days later, a close colleague at the track, Standardbred Owners Association President Joseph Faraldo, said he was quarantined in his New York City home waiting for his own test results.

“He could have infected the entire paddock, because he had contact with everybody,” said Faraldo, who fell ill himself a week ago. He said he was tested Wednesday at a medical facility in Queens and expected to get the results back by Friday.

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“I think I was pretty lucky," he said. “I wasn’t there more than 40 minutes. They asked a whole series of questions and I told them I was in the company of a person who had died from this. They were very nice.”

The Associated Press contributed to this report.