Republican presidential candidate Donald Trump Donald John TrumpHR McMaster says president's policy to withdraw troops from Afghanistan is 'unwise' Cast of 'Parks and Rec' reunite for virtual town hall to address Wisconsin voters Biden says Trump should step down over coronavirus response MORE has won the Virginia primary, major news outlets are projecting.

It marks his fifth victory of the night, following wins in Georgia, Alabama, Massachusetts and Tennessee.

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Trump’s wins deal painful blows to his rivals — particularly Sen. Marco Rubio Marco Antonio RubioFlorida senators pushing to keep Daylight Savings Time during pandemic Hillicon Valley: DOJ indicts Chinese, Malaysian hackers accused of targeting over 100 organizations | GOP senators raise concerns over Oracle-TikTok deal | QAnon awareness jumps in new poll Intelligence chief says Congress will get some in-person election security briefings MORE — who had hoped to stall Trump's momentum, which is building seemingly inexorably toward the Republican nomination.

Trump cannot accumulate enough delegates to win the nomination outright on Tuesday, but GOP strategists concede privately that a huge night would make him nearly impossible to stop.

Trump’s victory in Virginia is of particular importance. The Rubio camp had targeted the Old Dominion as one of its must-win Super Tuesday states, according to two senior sources familiar with the campaign’s internal planning.

Virginia has a large number of wealthy and well-educated Republican voters. Trump’s ability to win there will send further chills down the spines of party establishment figures who are frantically plotting strategies to stop the billionaire populist from securing the GOP nomination.