The vice president also leveled severe criticism at Donald Trump, calling the Republican presidential nominee “devoid of facts” for challenging the U.S. intelligence community's conclusion that Russia hacked the emails of the Democratic National Committee and top Clinton deputy John Podesta.

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“Think about what that says to the rest of the world,” Biden said of Trump's doubts.

“It's bizarre. I don't know whether he just doesn't know. He just might not be informed enough to know what he is saying. … It's hard to believe he could be so devoid of the facts. So it's either a deliberate attempt to undermine, or it's totally uninformed.”

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As for his ally Clinton, Biden said her appearance of being secretive is a matter of personal style, not of her integrity or honesty as a candidate.

“I don't think she understood the gravity of setting it up,” Biden said of the Clinton email server.

“She thought this was okay to do. And this woman has been so battered over the last 30 years, I think that when faced with the fact this was a problem, instead of just cutting it and dealing with it immediately, there's always an inclination to overthink it. ...

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“When you have been on the other end of a concerted effort, justified or not justified, to undermine your credibility, I think you are probably in a different place in terms of your instinct [on] how to respond. ... There's a sector of the electorate that has a tendency at least over 30 some years with Hillary to cause her to close rather than open.”

Biden's comments speak to common criticisms of Clinton on the left — that her long history as a target for Republican attacks has made her insulate herself.

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“I think she also knows that when she's elected, she's going to have to be prepared to be more open as president as to what her feelings are about things,” Biden said.

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Asked whether Clinton needs people around her to challenge that instinct, Biden said she “knows she does.” But he suggested that Clinton also deserves sympathy as the victim of a double standard.

“If I go out and get filled up [crying] talking about my Beau, my son who died, people say, 'Well, he's just a good, decent father, an honorable man,'" Biden said.