The family of a young disabled man allegedly abused by a male nurse inside a Melbourne hospital have spoken of their heartache and anger.

In an exclusive interview with A Current Affair , the sisters of Billy Aivaliotis say they felt "helpless" when they saw the footage of their brother apparently in distress while being treated at Caulfield Hospital.

"It's heart-wrenching," Effie Stagnitti said.

Effie Stagnitti and Zoe Bonello are the sisters of Billy Aivaliotis, a disabled man allegedly abused by a nurse while in hospital.

"He didn't deserve that."

The sisters had become suspicious of staff, after they allegedly started noticing bruises on Billy's arms, and a distinct change in his behaviour.

"Everytime I would look at him, I could just see the sadness," sister Zoe Bonello said.

Billy was born with cerebral palsy and was left with a brain injury after being struck by a car last year.

"I could see that he was trying to tell me something, but it was like he was stuck in his own little bubble."

Billy was born with cerebral palsy, and struggles to communicate.

Last May, he was hit by a car and suffered serious brain injuries.

The sisters set up a hidden camera inside a picture frame in his room, and that's how they discovered the alleged mistreatment.

The footage appears to show Billy being grabbed around the neck and thrown back by the nurse.

In the vision, a male nurse can be apparently seen putting his hand over Billy's throat, and the 33-year-old can be heard screaming.

The staff member involved as stood down, and no longer works for Alfred Health.

Victoria Police is also now investigating, and law firm Arnold Thomas and Becker has launched civil proceedings against Caulfield Hospital.

In another part of the footage, the nurse appears to hold Billy down on the bed.

"We're waiting on the police and hopefully charges can be made," Mrs Stagnitti said.

The sisters are calling for a complete overhaul of the health-care sector.