Bardeesy N.

Aguirre A.J.

Chu G.C.

Cheng K.H.

Lopez L.V.

Hezel A.F.

Feng B.

Brennan C.

Weissleder R.

Mahmood U.

et al. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc. Natl. Acad. Sci. USA. 103 : 5947-5952 View in Article Scopus (386)

PubMed

Crossref

Google Scholar

Bhatia M.

Brady M.

Kang Y.K.

Costello E.

Newton D.J.

Christmas S.E.

Neoptolemos J.P.

Slavin J. MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulein hyperstimulation. Am. J. Physiol. Gastrointest. Liver Physiol. 282 : G77-G85 View in Article PubMed

Google Scholar

Blinman T.A.

Gukovsky I.

Mouria M.

Zaninovic V.

Livingston E.

Pandol S.J.

Gukovskaya A.S. Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase. Am. J. Physiol. Cell Physiol. 279 : C1993-C2003 View in Article PubMed

Google Scholar

Crawford H.C.

Scoggins C.R.

Washington M.K.

Matrisian L.M.

Leach S.D. Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas. J. Clin. Invest. 109 : 1437-1444 View in Article Scopus (168)

PubMed

Crossref

Google Scholar

De La O.J.P.

Emerson L.L.

Goodman J.L.

Froebe S.C.

Illum B.E.

Curtis A.B.

Murtaugh L.C. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc. Natl. Acad. Sci. USA. 105 : 18907-18912 View in Article Scopus (266)

PubMed

Crossref

Google Scholar

Ernst M.

Najdovska M.

Grail D.

Lundgren-May T.

Buchert M.

Tye H.

Matthews V.B.

Armes J.

Bhathal P.S.

Hughes N.R.

et al. STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice. J. Clin. Invest. 118 : 1727-1738 View in Article PubMed

Google Scholar

Fukushima H.

Yamamoto H.

Itoh F.

Nakamura H.

Min Y.

Horiuchi S.

Iku S.

Sasaki S.

Imai K. Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas. Carcinogenesis. 22 : 1049-1052 View in Article Scopus (22)

PubMed

Crossref

Google Scholar

Habbe N.

Shi G.

Meguid R.A.

Fendrich V.

Esni F.

Chen H.

Feldmann G.

Stoffers D.A.

Konieczny S.F.

Leach S.D.

Maitra A. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc. Natl. Acad. Sci. USA. 105 : 18913-18918 View in Article Scopus (245)

PubMed

Crossref

Google Scholar

Jones L.E.

Humphreys M.J.

Campbell F.

Neoptolemos J.P.

Boyd M.T. Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival. Clin. Cancer Res. 10 : 2832-2845 View in Article Scopus (156)

PubMed

Crossref

Google Scholar

Jones S.

Zhang X.

Parsons D.W.

Lin J.C.

Leary R.J.

Angenendt P.

Mankoo P.

Carter H.

Kamiyama H.

Jimeno A.

et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 321 : 1801-1806 View in Article Scopus (2694)

PubMed

Crossref

Google Scholar

Kawaguchi Y.

Cooper B.

Gannon M.

Ray M.

MacDonald R.J.

Wright C.V. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat. Genet. 32 : 128-134 View in Article Scopus (705)

PubMed

Crossref

Google Scholar

Li Y.

Du H.

Qin Y.

Roberts J.

Cummings O.W.

Yan C. Activation of the signal transducers and activators of the transcription 3 pathway in alveolar epithelial cells induces inflammation and adenocarcinomas in mouse lung. Cancer Res. 67 : 8494-8503 View in Article Scopus (109)

PubMed

Crossref

Google Scholar

Lin L.

Amin R.

Gallicano G.I.

Glasgow E.

Jogunoori W.

Jessup J.M.

Zasloff M.

Marshall J.L.

Shetty K.

Johnson L.

et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene. 28 : 961-972 View in Article Scopus (170)

PubMed

Crossref

Google Scholar

Littlepage L.E.

Sternlicht M.D.

Rougier N.

Phillips J.

Gallo E.

Yu Y.

Williams K.

Brenot A.

Gordon J.I.

Werb Z. Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression. Cancer Res. 70 : 2224-2234 View in Article Scopus (136)

PubMed

Crossref

Google Scholar

Lowenfels A.B.

Maisonneuve P.

Cavallini G.

Ammann R.W.

Lankisch P.G.

Andersen J.R.

Dimagno E.P.

Andrén-Sandberg A.

Domellöf L. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N. Engl. J. Med. 328 : 1433-1437 View in Article Scopus (1376)

PubMed

Crossref

Google Scholar

Martinez-Romero C.

Rooman I.

Skoudy A.

Guerra C.

Molero X.

Gonzalez A.

Iglesias M.

Lobato T.

Bosch A.

Barbacid M.

et al. The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. J. Pathol. 219 : 205-213 View in Article Scopus (42)

PubMed

Crossref

Google Scholar

Means A.L.

Meszoely I.M.

Suzuki K.

Miyamoto Y.

Rustgi A.K.

Coffey Jr., R.J.

Wright C.V.

Stoffers D.A.

Leach S.D. Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development. 132 : 3767-3776 View in Article Scopus (233)

PubMed

Crossref

Google Scholar

Miyatsuka T.

Kaneto H.

Shiraiwa T.

Matsuoka T.A.

Yamamoto K.

Kato K.

Nakamura Y.

Akira S.

Takeda K.

Kajimoto Y.

et al. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev. 20 : 1435-1440 View in Article Scopus (109)

PubMed

Crossref

Google Scholar

Remy L.

Trespeuch C.

Bachy S.

Scoazec J.Y.

Rousselle P. Matrilysin 1 influences colon carcinoma cell migration by cleavage of the laminin-5 beta3 chain. Cancer Res. 66 : 11228-11237 View in Article Scopus (52)

PubMed

Crossref

Google Scholar

Siddiquee K.

Zhang S.

Guida W.C.

Blaskovich M.A.

Greedy B.

Lawrence H.R.

Yip M.L.

Jove R.

McLaughlin M.M.

Lawrence N.J.

et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc. Natl. Acad. Sci. USA. 104 : 7391-7396 View in Article Scopus (527)

PubMed

Crossref

Google Scholar

Strobel O.

Dor Y.

Stirman A.

Trainor A.

Fernandez-del Castillo C.

Warshaw A.L.

Thayer S.P. Beta cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal lesions of the pancreas by genetic lineage tracing in vivo. Proc. Natl. Acad. Sci. USA. 104 : 4419-4424 View in Article Scopus (46)

PubMed

Crossref

Google Scholar

Takeda K.

Kaisho T.

Yoshida N.

Takeda J.

Kishimoto T.

Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J. Immunol. 161 : 4652-4660 View in Article PubMed

Google Scholar

Udayakumar T.S.

Stratton M.S.

Nagle R.B.

Bowden G.T. Fibroblast growth factor-1 induced promatrilysin expression through the activation of extracellular-regulated kinases and STAT3. Neoplasia. 4 : 60-67 View in Article PubMed

Crossref

Google Scholar

Yamamoto H.

Itoh F.

Iku S.

Adachi Y.

Fukushima H.

Sasaki S.

Mukaiya M.

Hirata K.

Imai K. Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human pancreatic adenocarcinomas: clinicopathologic and prognostic significance of matrilysin expression. J. Clin. Oncol. 19 : 1118-1127 View in Article PubMed

Google Scholar