All causes 55 945·7 (55 356·4 to 56 516·7) 9·3% (8·2 to 10·2) * * Percentage changes that are statistically significant. 737·7 (729·9 to 745·4) −14·2% (−15·0 to −13·5) * * Percentage changes that are statistically significant. 1 646 249·6 (1 622 870·6 to 1 673 178·4) −9·0% (−10·1 to −7·6) * * Percentage changes that are statistically significant. 21 926·4 (21 601·1 to 22 314·9) −22·2% (−23·2 to −21·0) * * Percentage changes that are statistically significant.

Communicable, maternal, neonatal, and nutritional diseases 10 389·9 (10 004·0 to 10 975·9) −22·2% (−24·0 to −20·0) * * Percentage changes that are statistically significant. 143·8 (138·4 to 151·6) −31·8% (−33·3 to −30·1) * * Percentage changes that are statistically significant. 578 416·6 (558 815·0 to 600 759·1) −30·4% (−32·4 to −28·2) * * Percentage changes that are statistically significant. 8280·6 (8005·4 to 8602·8) −35·4% (−37·3 to −33·4) * * Percentage changes that are statistically significant.

HIV/AIDS and sexually transmitted infections 1073·6 (983·3 to 1182·4) −47·7% (−50·0 to −45·1) * * Percentage changes that are statistically significant. 13·9 (12·6 to 15·5) −53·6% (−55·8 to −51·0) * * Percentage changes that are statistically significant. 60 550·2 (53 533·7 to 69 156·3) −47·3% (−50·2 to −44·0) * * Percentage changes that are statistically significant. 806·4 (703·1 to 936·7) −52·1% (−55·2 to −48·6) * * Percentage changes that are statistically significant.

HIV/AIDS 954·5 (907·3 to 1009·7) −50·3% (−52·1 to −48·3) * * Percentage changes that are statistically significant. 12·1 (11·5 to 12·9) −56·5% (−58·0 to −54·7) * * Percentage changes that are statistically significant. 50 497·1 (47 658·0 to 53 595·8) −51·2% (−52·9 to −49·2) * * Percentage changes that are statistically significant. 655·1 (617·5 to 696·4) −56·6% (−58·1 to −54·8) * * Percentage changes that are statistically significant.

HIV/AIDS and drug-susceptible tuberculosis co-infection 194·6 (137·7 to 253·0) −55·4% (−58·4 to −51·6) * * Percentage changes that are statistically significant. 2·5 (1·8 to 3·2) −61·1% (−63·7 to −57·7) * * Percentage changes that are statistically significant. 10 664·8 (7613·4 to 13 757·1) −55·6% (−58·7 to −51·7) * * Percentage changes that are statistically significant. 140·0 (100·2 to 180·0) −60·5% (−63·1 to −57·0) * * Percentage changes that are statistically significant.

HIV/AIDS and multidrug-resistant tuberculosis without extensive drug resistance co-infection 22·6 (13·4 to 34·5) −52·2% (−66·4 to −33·2) * * Percentage changes that are statistically significant. 0·3 (0·2 to 0·4) −58·1% (−70·5 to −41·5) * * Percentage changes that are statistically significant. 1247·8 (746·6 to 1906·7) −51·7% (−65·7 to −33·2) * * Percentage changes that are statistically significant. 16·4 (9·8 to 25·1) −56·8% (−69·3 to −40·4) * * Percentage changes that are statistically significant.

HIV/AIDS and extensively drug-resistant tuberculosis co-infection 1·2 (0·8 to 1·8) −8·3% (−26·8 to 14·7) 0·0 (0·0 to 0·0) −20·3% (−36·4 to −0·2) * * Percentage changes that are statistically significant. 62·7 (38·3 to 92·9) −10·5% (−28·4 to 11·5) 0·8 (0·5 to 1·2) −21·0% (−36·7 to −1·4) * * Percentage changes that are statistically significant.

HIV/AIDS resulting in other diseases 736·0 (659·5 to 817·7) −48·7% (−51·1 to −45·9) * * Percentage changes that are statistically significant. 9·3 (8·4 to 10·4) −55·1% (−57·2 to −52·6) * * Percentage changes that are statistically significant. 38 521·8 (34 381·3 to 43 095·5) −49·8% (−52·3 to −46·9) * * Percentage changes that are statistically significant. 497·9 (444·2 to 558·4) −55·4% (−57·6 to −52·8) * * Percentage changes that are statistically significant.

Sexually transmitted infections excluding HIV 119·1 (50·8 to 220·4) −10·8% (−18·4 to −2·5) * * Percentage changes that are statistically significant. 1·8 (0·7 to 3·3) −14·4% (−21·5 to −6·6) * * Percentage changes that are statistically significant. 10 053·1 (4057·0 to 18 915·2) −11·4% (−19·0 to −3·2) * * Percentage changes that are statistically significant. 151·3 (60·6 to 285·3) −14·4% (−21·8 to −6·6) * * Percentage changes that are statistically significant.

Syphilis 113·5 (45·2 to 214·5) −11·3% (−19·1 to −2·8) * * Percentage changes that are statistically significant. 1·7 (0·7 to 3·2) −14·3% (−21·8 to −6·4) * * Percentage changes that are statistically significant. 9836·1 (3848·5 to 18 676·4) −11·5% (−19·3 to −3·1) * * Percentage changes that are statistically significant. 148·6 (58·0 to 282·3) −14·3% (−21·8 to −6·2) * * Percentage changes that are statistically significant.

Chlamydial infection 1·1 (0·9 to 1·2) 2·5% (−4·5 to 11·3) 0·0 (0·0 to 0·0) −15·2% (−21·0 to −8·4) * * Percentage changes that are statistically significant. 40·5 (32·6 to 45·0) −5·5% (−12·2 to 2·5) 0·5 (0·4 to 0·6) −17·9% (−23·7 to −11·0) * * Percentage changes that are statistically significant.

Gonococcal infection 3·0 (2·4 to 3·3) 3·7% (−3·4 to 12·5) 0·0 (0·0 to 0·0) −14·9% (−20·8 to −8·2) * * Percentage changes that are statistically significant. 112·8 (90·2 to 124·9) −3·8% (−10·7 to 4·3) 1·4 (1·1 to 1·6) −17·4% (−23·5 to −10·7) * * Percentage changes that are statistically significant.

Other sexually transmitted infections 1·5 (1·2 to 1·7) 0·2% (−6·4 to 8·3) 0·0 (0·0 to 0·0) −15·9% (−21·6 to −9·5) * * Percentage changes that are statistically significant. 63·6 (51·0 to 70·7) −6·2% (−12·7 to 1·1) 0·8 (0·6 to 0·9) −18·2% (−23·9 to −11·7) * * Percentage changes that are statistically significant.

Respiratory infections and tuberculosis 3752·3 (3629·4 to 3889·3) −8·0% (−10·3 to −5·5) * * Percentage changes that are statistically significant. 50·5 (48·8 to 52·3) −24·5% (−26·4 to −22·6) * * Percentage changes that are statistically significant. 148 233·5 (141 335·1 to 155 291·4) −24·7% (−27·4 to −21·7) * * Percentage changes that are statistically significant. 2056·0 (1956·3 to 2160·7) −32·8% (−35·4 to −30·0) * * Percentage changes that are statistically significant.

Tuberculosis 1183·7 (1129·8 to 1245·3) −14·9% (−18·2 to −10·3) * * Percentage changes that are statistically significant. 14·9 (14·3 to 15·7) −31·4% (−34·1 to −27·6) * * Percentage changes that are statistically significant. 41 876·9 (39 972·4 to 44 120·5) −21·2% (−24·4 to −17·4) * * Percentage changes that are statistically significant. 533·4 (509·1 to 562·6) −33·3% (−35·9 to −30·0) * * Percentage changes that are statistically significant.

Drug-susceptible tuberculosis 1044·1 (951·6 to 1129·2) −15·5% (−22·3 to −8·6) * * Percentage changes that are statistically significant. 13·2 (12·0 to 14·2) −31·9% (−37·3 to −26·4) * * Percentage changes that are statistically significant. 36 932·5 (33 846·8 to 39 919·1) −21·9% (−27·8 to −16·0) * * Percentage changes that are statistically significant. 470·7 (431·3 to 508·4) −33·8% (−38·7 to −29·0) * * Percentage changes that are statistically significant.

Multidrug-resistant tuberculosis without extensive drug resistance 126·9 (70·1 to 202·2) −11·6% (−47·4 to 38·1) 1·6 (0·9 to 2·5) −28·6% (−57·4 to 11·4) 4505·1 (2582·5 to 6984·6) −17·6% (−49·4 to 26·5) 57·2 (33·0 to 88·4) −30·2% (−56·9 to 6·6)

Extensively drug-resistant tuberculosis 12·6 (8·6 to 18·0) 14·0% (−18·7 to 58·7) 0·2 (0·1 to 0·2) −7·7% (−34·1 to 28·8) 439·2 (306·2 to 616·5) 5·5% (−23·2 to 44·9) 5·5 (3·8 to 7·7) −11·1% (−35·2 to 22·1)

Lower respiratory infections 2558·6 (2442·2 to 2655·4) −4·3% (−6·9 to −1·5) * * Percentage changes that are statistically significant. 35·4 (33·8 to 36·8) −21·1% (−23·2 to −18·9) * * Percentage changes that are statistically significant. 105 834·5 (99 746·4 to 111 767·8) −25·9% (−29·2 to −22·2) * * Percentage changes that are statistically significant. 1515·1 (1424·8 to 1602·2) −32·6% (−35·7 to −29·2) * * Percentage changes that are statistically significant.

Upper respiratory infections 9·1 (6·1 to 12·4) −30·5% (−41·0 to −14·5) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·2) −42·1% (−49·6 to −29·9) * * Percentage changes that are statistically significant. 477·3 (247·3 to 730·5) −33·2% (−44·1 to −12·9) * * Percentage changes that are statistically significant. 6·9 (3·5 to 10·6) −38·6% (−48·3 to −19·4) * * Percentage changes that are statistically significant.

Otitis media 0·9 (0·7 to 1·5) −41·4% (−51·6 to −28·4) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) −50·4% (−58·8 to −39·9) * * Percentage changes that are statistically significant. 44·8 (31·2 to 72·1) −49·4% (−59·9 to −35·5) * * Percentage changes that are statistically significant. 0·6 (0·4 to 1·0) −54·5% (−64·1 to −41·8) * * Percentage changes that are statistically significant.

Enteric infections 1766·0 (1398·0 to 2386·0) −17·2% (−24·6 to −8·2) * * Percentage changes that are statistically significant. 24·4 (19·5 to 32·4) −29·9% (−34·9 to −23·1) * * Percentage changes that are statistically significant. 84 625·5 (73 770·6 to 100 720·2) −30·6% (−36·3 to −23·7) * * Percentage changes that are statistically significant. 1208·6 (1064·1 to 1424·7) −36·6% (−41·8 to −30·7) * * Percentage changes that are statistically significant.

Diarrhoeal diseases 1569·6 (1176·0 to 2193·0) −16·6% (−25·3 to −6·7) * * Percentage changes that are statistically significant. 21·6 (16·4 to 29·7) −30·2% (−36·1 to −22·7) * * Percentage changes that are statistically significant. 70 574·3 (60 421·1 to 86 165·2) −32·0% (−38·6 to −23·9) * * Percentage changes that are statistically significant. 1009·1 (870·5 to 1211·0) −38·1% (−43·9 to −31·3) * * Percentage changes that are statistically significant.

Typhoid and paratyphoid 135·9 (76·9 to 218·9) −22·3% (−27·3 to −18·1) * * Percentage changes that are statistically significant. 1·9 (1·1 to 3·0) −27·8% (−32·8 to −23·9) * * Percentage changes that are statistically significant. 9686·1 (5484·9 to 15 746·2) −23·8% (−29·3 to −19·4) * * Percentage changes that are statistically significant. 136·3 (77·0 to 220·9) −28·7% (−34·0 to −24·4) * * Percentage changes that are statistically significant.

Typhoid fever 116·8 (65·4 to 187·7) −23·7% (−29·0 to −19·3) * * Percentage changes that are statistically significant. 1·6 (0·9 to 2·6) −29·1% (−34·1 to −25·0) * * Percentage changes that are statistically significant. 8331·7 (4632·5 to 13 419·2) −25·3% (−31·0 to −20·8) * * Percentage changes that are statistically significant. 117·3 (65·5 to 188·5) −30·1% (−35·6 to −25·7) * * Percentage changes that are statistically significant.

Paratyphoid fever 19·1 (8·7 to 37·3) −12·7% (−20·1 to −4·2) * * Percentage changes that are statistically significant. 0·3 (0·1 to 0·5) −18·9% (−26·1 to −10·8) * * Percentage changes that are statistically significant. 1354·4 (622·3 to 2620·2) −13·2% (−21·3 to −3·8) * * Percentage changes that are statistically significant. 19·0 (8·8 to 36·6) −18·6% (−26·5 to −9·7) * * Percentage changes that are statistically significant.

Invasive non-typhoidal salmonella 59·1 (33·3 to 98·1) −17·9% (−25·1 to −8·7) * * Percentage changes that are statistically significant. 0·8 (0·5 to 1·4) −24·8% (−31·9 to −15·6) * * Percentage changes that are statistically significant. 4260·8 (2382·0 to 7378·6) −17·2% (−25·7 to −6·8) * * Percentage changes that are statistically significant. 61·6 (34·7 to 107·6) −22·6% (−30·7 to −12·5) * * Percentage changes that are statistically significant.

Other intestinal infectious diseases 1·4 (1·0 to 2·2) −39·7% (−67·1 to 9·7) 0·0 (0·0 to 0·0) −44·7% (−70·1 to 2·3) 104·4 (67·8 to 170·7) −43·6% (−71·6 to 11·9) 1·5 (1·0 to 2·5) −46·9% (−73·7 to 6·3)

Neglected tropical diseases and malaria 720·1 (530·7 to 938·8) −29·0% (−37·3 to −19·3) * * Percentage changes that are statistically significant. 10·1 (7·5 to 13·2) −36·1% (−43·7 to −27·3) * * Percentage changes that are statistically significant. 48 656·2 (35 574·6 to 64 934·2) −33·7% (−42·4 to −23·7) * * Percentage changes that are statistically significant. 699·9 (508·0 to 933·6) −38·6% (−46·7 to −29·2) * * Percentage changes that are statistically significant.

Malaria 619·8 (440·1 to 839·5) −30·8% (−39·4 to −20·8) * * Percentage changes that are statistically significant. 8·7 (6·1 to 11·9) −37·3% (−45·4 to −27·9) * * Percentage changes that are statistically significant. 43 546·6 (29 966·3 to 59 772·4) −34·5% (−43·8 to −23·6) * * Percentage changes that are statistically significant. 629·4 (432·6 to 858·7) −39·2% (−48·2 to −28·8) * * Percentage changes that are statistically significant.

Chagas disease 7·9 (7·5 to 8·6) 3·8% (−1·6 to 12·9) 0·1 (0·1 to 0·1) −21·1% (−25·2 to −14·3) * * Percentage changes that are statistically significant. 174·9 (166·1 to 193·5) −4·2% (−9·0 to 4·8) 2·2 (2·0 to 2·4) −25·1% (−28·9 to −18·1) * * Percentage changes that are statistically significant.

Leishmaniasis 7·5 (0·0 to 34·5) −64·8% (−96·8 to −44·5) * * Percentage changes that are statistically significant. 0·1 (0·0 to 0·5) −67·8% (−97·5 to −50·3) * * Percentage changes that are statistically significant. 509·8 (0·3 to 2440·2) −63·8% (−92·1 to −39·7) * * Percentage changes that are statistically significant. 7·2 (0·0 to 34·6) −66·2% (−93·2 to −43·8) * * Percentage changes that are statistically significant.

Visceral leishmaniasis 7·5 (0·0 to 34·5) −64·8% (−96·8 to −44·5) * * Percentage changes that are statistically significant. 0·1 (0·0 to 0·5) −67·8% (−97·5 to −50·3) * * Percentage changes that are statistically significant. 509·8 (0·3 to 2440·2) −63·8% (−92·1 to −39·7) * * Percentage changes that are statistically significant. 7·2 (0·0 to 34·6) −66·2% (−93·2 to −43·8) * * Percentage changes that are statistically significant.

African trypanosomiasis 1·4 (0·3 to 4·9) −80·7% (−95·6 to −27·8) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·1) −82·8% (−96·0 to −34·3) * * Percentage changes that are statistically significant. 77·6 (15·0 to 283·6) −80·8% (−95·6 to −27·2) * * Percentage changes that are statistically significant. 1·0 (0·2 to 3·8) −82·3% (−96·0 to −33·6) * * Percentage changes that are statistically significant.

Schistosomiasis 8·8 (8·0 to 9·8) −12·3% (−17·6 to −6·4) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·1) −28·5% (−32·7 to −23·7) * * Percentage changes that are statistically significant. 342·3 (305·3 to 384·3) −15·6% (−21·9 to −8·8) * * Percentage changes that are statistically significant. 4·4 (3·9 to 5·0) −27·4% (−32·9 to −21·4) * * Percentage changes that are statistically significant.

Cysticercosis 0·7 (0·5 to 1·0) −15·9% (−42·7 to 23·3) 0·0 (0·0 to 0·0) −27·3% (−50·5 to 5·3) 39·6 (26·9 to 55·0) −20·5% (−46·9 to 18·2) 0·5 (0·4 to 0·7) −28·9% (−52·5 to 4·8)

Cystic echinococcosis 1·2 (0·9 to 1·5) −30·0% (−52·1 to −1·3) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) −41·9% (−59·8 to −19·0) * * Percentage changes that are statistically significant. 52·0 (38·1 to 68·0) −38·8% (−56·8 to −12·9) * * Percentage changes that are statistically significant. 0·7 (0·5 to 0·9) −46·4% (−62·0 to −24·1) * * Percentage changes that are statistically significant.

Dengue 40·5 (17·6 to 49·8) 65·5% (21·7 to 99·7) * * Percentage changes that are statistically significant. 0·5 (0·2 to 0·7) 40·7% (3·6 to 69·7) * * Percentage changes that are statistically significant. 1902·9 (716·6 to 2312·9) 32·0% (−1·8 to 61·2) 26·1 (9·8 to 31·7) 18·2% (−12·0 to 45·0)

Yellow fever 4·8 (1·0 to 13·8) −16·6% (−28·7 to −2·0) * * Percentage changes that are statistically significant. 0·1 (0·0 to 0·2) −23·3% (−34·4 to −9·6) * * Percentage changes that are statistically significant. 313·9 (67·2 to 900·2) −16·0% (−28·9 to 0·0) 4·3 (0·9 to 12·4) −21·3% (−33·6 to −5·8) * * Percentage changes that are statistically significant.

Rabies 11·7 (9·3 to 14·7) −48·1% (−58·8 to −37·3) * * Percentage changes that are statistically significant. 0·2 (0·1 to 0·2) −54·8% (−63·8 to −45·0) * * Percentage changes that are statistically significant. 633·7 (504·4 to 836·4) −51·5% (−61·3 to −38·9) * * Percentage changes that are statistically significant. 8·6 (6·8 to 11·5) −56·2% (−65·1 to −44·3) * * Percentage changes that are statistically significant.

Intestinal nematode infections 3·2 (2·5 to 4·1) −43·1% (−56·1 to −25·0) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·1) −47·2% (−59·5 to −30·1) * * Percentage changes that are statistically significant. 257·1 (194·1 to 336·3) −44·1% (−57·6 to −25·0) * * Percentage changes that are statistically significant. 3·8 (2·9 to 5·0) −47·6% (−60·4 to −29·6) * * Percentage changes that are statistically significant.

Ascariasis 3·2 (2·5 to 4·1) −43·1% (−56·1 to −25·0) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·1) −47·2% (−59·5 to −30·1) * * Percentage changes that are statistically significant. 257·1 (194·1 to 336·3) −44·1% (−57·6 to −25·0) * * Percentage changes that are statistically significant. 3·8 (2·9 to 5·0) −47·6% (−60·4 to −29·6) * * Percentage changes that are statistically significant.

Ebola virus disease 0·0 (0·0 to 0·0) −98·2% (−98·4 to −98·0) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) −98·4% (−98·6 to −98·2) * * Percentage changes that are statistically significant. 0·5 (0·5 to 0·5) −98·1% (−98·3 to −97·9) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) −98·2% (−98·4 to −98·0) * * Percentage changes that are statistically significant.

Zika virus disease 0·0 (0·0 to 0·1) .. 0·0 (0·0 to 0·0) .. 1·0 (0·2 to 3·4) .. 0·0 (0·0 to 0·0) ..

Other neglected tropical diseases 12·6 (8·0 to 36·3) 8·1% (−8·1 to 28·2) 0·2 (0·1 to 0·5) −3·7% (−18·3 to 13·9) 804·3 (442·8 to 2696·6) 3·9% (−16·3 to 29·4) 11·6 (6·3 to 39·6) −3·5% (−22·2 to 20·7)

Other infectious diseases 830·5 (732·2 to 947·8) −25·9% (−32·4 to −18·8) * * Percentage changes that are statistically significant. 11·6 (10·1 to 13·3) −33·8% (−39·3 to −27·4) * * Percentage changes that are statistically significant. 53 008·6 (44 786·0 to 63 000·4) −33·0% (−39·6 to −25·1) * * Percentage changes that are statistically significant. 762·8 (640·5 to 911·5) −37·9% (−44·0 to −30·5) * * Percentage changes that are statistically significant.

Meningitis 288·0 (254·3 to 333·2) −20·1% (−26·0 to −11·0) * * Percentage changes that are statistically significant. 4·0 (3·6 to 4·6) −27·8% (−33·1 to −19·3) * * Percentage changes that are statistically significant. 19 436·9 (16 935·1 to 22 335·8) −25·2% (−31·5 to −15·7) * * Percentage changes that are statistically significant. 280·5 (243·6 to 323·2) −30·2% (−36·3 to −21·4) * * Percentage changes that are statistically significant.

Pneumococcal meningitis 42·1 (36·6 to 49·4) −13·4% (−20·6 to −2·3) * * Percentage changes that are statistically significant. 0·6 (0·5 to 0·7) −22·4% (−28·9 to −12·4) * * Percentage changes that are statistically significant. 2751·8 (2325·8 to 3276·5) −18·5% (−26·8 to −6·5) * * Percentage changes that are statistically significant. 39·6 (33·4 to 47·0) −24·2% (−32·1 to −12·8) * * Percentage changes that are statistically significant.

H influenzae type B meningitis 75·7 (66·7 to 92·0) −33·7% (−39·6 to −26·0) * * Percentage changes that are statistically significant. 1·1 (0·9 to 1·3) −40·6% (−45·8 to −33·9) * * Percentage changes that are statistically significant. 4907·3 (4232·2 to 5813·6) −40·4% (−46·1 to −33·0) * * Percentage changes that are statistically significant. 70·5 (60·6 to 83·9) −44·7% (−50·1 to −37·7) * * Percentage changes that are statistically significant.

Meningococcal infection 30·0 (25·7 to 35·7) −31·5% (−37·4 to −22·8) * * Percentage changes that are statistically significant. 0·4 (0·4 to 0·5) −37·1% (−42·6 to −29·2) * * Percentage changes that are statistically significant. 2180·3 (1819·8 to 2614·5) −34·9% (−41·4 to −26·4) * * Percentage changes that are statistically significant. 31·9 (26·5 to 38·4) −38·8% (−45·0 to −30·5) * * Percentage changes that are statistically significant.

Other meningitis 140·3 (121·4 to 161·8) −8·9% (−15·4 to 1·4) 2·0 (1·7 to 2·3) −17·3% (−23·4 to −7·5) * * Percentage changes that are statistically significant. 9597·5 (8195·6 to 11 118·5) −12·8% (−20·4 to −0·7) * * Percentage changes that are statistically significant. 138·5 (118·3 to 160·5) −18·4% (−25·7 to −7·4) * * Percentage changes that are statistically significant.

Encephalitis 92·4 (83·1 to 107·9) 0·0% (−14·2 to 16·2) 1·2 (1·1 to 1·4) −14·3% (−26·5 to −0·9) * * Percentage changes that are statistically significant. 4588·2 (4059·5 to 5230·7) −12·1% (−28·1 to 4·5) 64·1 (56·6 to 72·4) −20·1% (−35·0 to −5·0) * * Percentage changes that are statistically significant.

Diphtheria 3·6 (2·2 to 6·1) −23·9% (−55·6 to 36·4) 0·1 (0·0 to 0·1) −28·6% (−58·8 to 29·2) 298·7 (181·8 to 510·0) −23·9% (−56·7 to 38·7) 4·4 (2·7 to 7·6) −28·3% (−59·5 to 31·4)

Whooping cough 91·8 (45·9 to 163·2) −23·3% (−54·8 to 35·6) 1·4 (0·7 to 2·4) −27·1% (−57·1 to 28·8) 7879·2 (3938·1 to 14 010·3) −23·3% (−54·8 to 35·4) 117·9 (58·9 to 209·6) −27·1% (−57·0 to 28·8)

Tetanus 38·1 (25·9 to 48·8) −54·9% (−65·9 to −39·1) * * Percentage changes that are statistically significant. 0·5 (0·4 to 0·7) −59·6% (−69·3 to −45·0) * * Percentage changes that are statistically significant. 2447·7 (1734·9 to 3199·0) −59·3% (−69·9 to −43·5) * * Percentage changes that are statistically significant. 35·1 (25·0 to 46·3) −62·1% (−72·1 to −47·0) * * Percentage changes that are statistically significant.

Measles 95·3 (34·5 to 205·2) −57·0% (−61·9 to −51·9) * * Percentage changes that are statistically significant. 1·4 (0·5 to 3·1) −59·3% (−64·0 to −54·4) * * Percentage changes that are statistically significant. 8105·1 (2935·7 to 17 469·0) −56·9% (−61·8 to −51·8) * * Percentage changes that are statistically significant. 120·8 (43·7 to 260·4) −59·2% (−63·9 to −54·3) * * Percentage changes that are statistically significant.

Varicella and herpes zoster 15·6 (14·4 to 17·3) −16·4% (−22·9 to −9·5) * * Percentage changes that are statistically significant. 0·2 (0·2 to 0·2) −29·2% (−34·7 to −23·4) * * Percentage changes that are statistically significant. 833·0 (742·3 to 938·1) −22·5% (−31·4 to −13·2) * * Percentage changes that are statistically significant. 12·1 (10·7 to 13·6) −28·4% (−36·6 to −19·4) * * Percentage changes that are statistically significant.

Acute hepatitis 126·4 (94·5 to 143·7) −9·8% (−15·5 to −2·3) * * Percentage changes that are statistically significant. 1·6 (1·2 to 1·9) −24·5% (−29·2 to −18·4) * * Percentage changes that are statistically significant. 5478·4 (4040·3 to 6330·0) −21·7% (−27·7 to −14·4) * * Percentage changes that are statistically significant. 72·3 (52·9 to 83·9) −31·2% (−36·5 to −24·9) * * Percentage changes that are statistically significant.

Acute hepatitis A 18·6 (13·6 to 23·8) −33·1% (−41·9 to −22·5) * * Percentage changes that are statistically significant. 0·3 (0·2 to 0·3) −38·7% (−46·8 to −28·6) * * Percentage changes that are statistically significant. 1286·7 (935·2 to 1633·7) −36·0% (−45·1 to −24·3) * * Percentage changes that are statistically significant. 18·0 (13·0 to 22·9) −40·7% (−49·1 to −29·0) * * Percentage changes that are statistically significant.

Acute hepatitis B 89·6 (66·1 to 102·5) −0·8% (−8·4 to 8·5) 1·1 (0·8 to 1·3) −19·6% (−25·4 to −12·4) * * Percentage changes that are statistically significant. 3262·4 (2367·8 to 3819·1) −12·2% (−19·7 to −2·7) * * Percentage changes that are statistically significant. 41·8 (30·1 to 49·3) −25·6% (−31·9 to −17·5) * * Percentage changes that are statistically significant.

Acute hepatitis C 3·5 (1·9 to 6·0) −23·7% (−35·9 to −9·4) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·1) −32·1% (−42·4 to −19·6) * * Percentage changes that are statistically significant. 219·7 (120·1 to 371·3) −31·0% (−43·3 to −15·3) * * Percentage changes that are statistically significant. 3·2 (1·8 to 5·4) −35·5% (−47·2 to −20·7) * * Percentage changes that are statistically significant.

Acute hepatitis E 14·7 (10·4 to 18·5) −15·8% (−27·2 to −3·1) * * Percentage changes that are statistically significant. 0·2 (0·1 to 0·2) −25·8% (−35·3 to −15·6) * * Percentage changes that are statistically significant. 709·6 (489·6 to 903·9) −25·5% (−35·2 to −14·5) * * Percentage changes that are statistically significant. 9·3 (6·4 to 11·8) −31·9% (−40·6 to −22·0) * * Percentage changes that are statistically significant.

Other unspecified infectious diseases 79·3 (59·9 to 85·1) 1·6% (−3·1 to 7·9) 1·1 (0·8 to 1·2) −13·4% (−17·5 to −8·1) * * Percentage changes that are statistically significant. 3941·3 (2831·7 to 4325·8) −10·2% (−16·2 to −2·4) * * Percentage changes that are statistically significant. 55·6 (39·6 to 61·3) −17·9% (−23·6 to −10·6) * * Percentage changes that are statistically significant.

Maternal and neonatal disorders 1977·4 (1890·1 to 2060·6) −24·1% (−26·9 to −21·0) * * Percentage changes that are statistically significant. 29·5 (28·2 to 30·8) −26·6% (−29·3 to −23·5) * * Percentage changes that are statistically significant. 167 684·6 (160 060·7 to 174 918·2) −24·2% (−27·1 to −20·9) * * Percentage changes that are statistically significant. 2518·2 (2403·8 to 2627·1) −26·5% (−29·3 to −23·3) * * Percentage changes that are statistically significant.

Maternal disorders 193·6 (179·9 to 209·6) −24·0% (−28·4 to −19·5) * * Percentage changes that are statistically significant. 2·5 (2·3 to 2·7) −30·7% (−34·8 to −26·6) * * Percentage changes that are statistically significant. 10 993·1 (10 198·9 to 11 928·5) −25·3% (−29·7 to −20·9) * * Percentage changes that are statistically significant. 140·9 (130·8 to 153·0) −31·5% (−35·5 to −27·5) * * Percentage changes that are statistically significant.

Maternal haemorrhage 38·5 (33·2 to 45·2) −52·1% (−59·0 to −44·2) * * Percentage changes that are statistically significant. 0·5 (0·4 to 0·6) −56·4% (−62·7 to −49·3) * * Percentage changes that are statistically significant. 2173·8 (1859·7 to 2552·5) −53·0% (−60·1 to −45·0) * * Percentage changes that are statistically significant. 27·8 (23·8 to 32·7) −57·1% (−63·6 to −49·7) * * Percentage changes that are statistically significant.

Maternal sepsis and other pregnancy-related infections 21·2 (18·2 to 25·0) −27·1% (−38·8 to −15·1) * * Percentage changes that are statistically significant. 0·3 (0·2 to 0·3) −33·5% (−44·2 to −22·6) * * Percentage changes that are statistically significant. 1198·0 (1022·8 to 1420·8) −28·9% (−41·1 to −16·2) * * Percentage changes that are statistically significant. 15·4 (13·1 to 18·3) −34·5% (−45·4 to −22·5) * * Percentage changes that are statistically significant.

Maternal hypertensive disorders 29·4 (25·4 to 34·5) −5·5% (−20·7 to 11·2) 0·4 (0·3 to 0·4) −13·0% (−27·3 to 2·6) 1729·6 (1487·6 to 2033·2) −6·6% (−22·1 to 10·2) 22·3 (19·2 to 26·4) −13·6% (−28·1 to 2·0)

Maternal obstructed labour and uterine rupture 13·0 (10·2 to 16·8) −17·7% (−35·9 to 2·9) 0·2 (0·1 to 0·2) −25·2% (−41·0 to −6·3) * * Percentage changes that are statistically significant. 720·9 (565·5 to 946·4) −18·9% (−37·6 to 1·9) 9·2 (7·2 to 12·1) −25·8% (−42·9 to −6·9) * * Percentage changes that are statistically significant.

Maternal abortive outcome 17·4 (14·7 to 20·8) −7·0% (−22·3 to 10·1) 0·2 (0·2 to 0·3) −15·7% (−29·3 to −0·4) * * Percentage changes that are statistically significant. 963·4 (807·6 to 1161·1) −8·9% (−24·2 to 8·7) 12·3 (10·3 to 14·9) −16·8% (−30·7 to −0·5) * * Percentage changes that are statistically significant.

Ectopic pregnancy 10·2 (7·1 to 15·2) −11·6% (−41·4 to 27·9) 0·1 (0·1 to 0·2) −19·2% (−46·2 to 16·8) 590·6 (409·0 to 881·4) −13·3% (−43·8 to 26·9) 7·6 (5·3 to 11·4) −20·3% (−48·1 to 17·0)

Indirect maternal deaths 34·1 (30·0 to 38·7) −4·1% (−16·7 to 8·5) 0·4 (0·4 to 0·5) −12·5% (−24·0 to −1·0) * * Percentage changes that are statistically significant. 1934·4 (1694·2 to 2216·7) −6·1% (−19·2 to 6·8) 24·8 (21·7 to 28·5) −13·9% (−25·8 to −2·3) * * Percentage changes that are statistically significant.

Late maternal deaths 3·4 (2·6 to 4·3) −0·9% (−7·0 to 5·5) 0·0 (0·0 to 0·1) −9·5% (−14·7 to −4·0) * * Percentage changes that are statistically significant. 194·7 (152·2 to 251·4) −2·0% (−8·2 to 4·1) 2·5 (2·0 to 3·2) −10·1% (−15·4 to −4·5) * * Percentage changes that are statistically significant.

Maternal deaths aggravated by HIV/AIDS 1·6 (1·0 to 2·1) −23·9% (−31·0 to −16·0) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) −32·1% (−38·4 to −25·2) * * Percentage changes that are statistically significant. 84·4 (53·0 to 113·8) −26·7% (−33·6 to −19·2) * * Percentage changes that are statistically significant. 1·1 (0·7 to 1·4) −34·2% (−40·6 to −27·5) * * Percentage changes that are statistically significant.

Other maternal disorders 24·8 (20·8 to 29·8) −8·5% (−24·7 to 11·2) 0·3 (0·3 to 0·4) −16·5% (−31·2 to 1·5) 1403·1 (1159·5 to 1690·3) −9·8% (−26·7 to 10·8) 18·0 (14·9 to 21·7) −17·2% (−32·9 to 1·2)

Neonatal disorders 1783·8 (1698·5 to 1864·7) −24·1% (−27·2 to −20·6) * * Percentage changes that are statistically significant. 27·1 (25·8 to 28·3) −26·2% (−29·1 to −22·7) * * Percentage changes that are statistically significant. 156 691·6 (149 207·2 to 163 802·2) −24·1% (−27·2 to −20·6) * * Percentage changes that are statistically significant. 2377·2 (2263·7 to 2485·1) −26·2% (−29·1 to −22·7) * * Percentage changes that are statistically significant.

Neonatal preterm birth 649·4 (605·4 to 721·3) −26·2% (−31·3 to −21·5) * * Percentage changes that are statistically significant. 9·9 (9·2 to 10·9) −28·1% (−33·2 to −23·6) * * Percentage changes that are statistically significant. 57 052·0 (53 182·3 to 63 367·1) −26·2% (−31·3 to −21·5) * * Percentage changes that are statistically significant. 865·6 (806·9 to 961·5) −28·1% (−33·2 to −23·6) * * Percentage changes that are statistically significant.

Neonatal encephalopathy due to birth asphyxia and trauma 533·3 (476·9 to 580·3) −24·5% (−30·2 to −18·0) * * Percentage changes that are statistically significant. 8·1 (7·2 to 8·8) −26·5% (−32·0 to −20·2) * * Percentage changes that are statistically significant. 46 845·9 (41 894·1 to 50 985·7) −24·5% (−30·2 to −18·0) * * Percentage changes that are statistically significant. 710·8 (635·7 to 773·7) −26·5% (−32·0 to −20·2) * * Percentage changes that are statistically significant.

Neonatal sepsis and other neonatal infections 203·0 (178·7 to 267·1) −11·9% (−20·5 to −1·7) * * Percentage changes that are statistically significant. 3·1 (2·7 to 4·1) −14·4% (−22·7 to −4·4) * * Percentage changes that are statistically significant. 17 830·7 (15 692·9 to 23 459·0) −11·9% (−20·5 to −1·7) * * Percentage changes that are statistically significant. 270·4 (238·0 to 355·8) −14·4% (−22·7 to −4·4) * * Percentage changes that are statistically significant.

Haemolytic disease and other neonatal jaundice 49·1 (42·9 to 55·9) −37·5% (−45·3 to −28·2) * * Percentage changes that are statistically significant. 0·7 (0·7 to 0·8) −39·3% (−46·8 to −30·2) * * Percentage changes that are statistically significant. 4309·1 (3771·2 to 4914·0) −37·5% (−45·3 to −28·2) * * Percentage changes that are statistically significant. 65·4 (57·2 to 74·5) −39·3% (−46·8 to −30·2) * * Percentage changes that are statistically significant.

Other neonatal disorders 349·0 (294·9 to 382·3) −23·6% (−29·8 to −15·5) * * Percentage changes that are statistically significant. 5·3 (4·5 to 5·8) −25·7% (−31·7 to −17·8) * * Percentage changes that are statistically significant. 30 654·0 (25 899·7 to 33 578·7) −23·6% (−29·8 to −15·5) * * Percentage changes that are statistically significant. 465·0 (392·9 to 509·4) −25·7% (−31·7 to −17·8) * * Percentage changes that are statistically significant.

Nutritional deficiencies 270·0 (249·3 to 295·5) −23·9% (−29·2 to −15·7) * * Percentage changes that are statistically significant. 3·8 (3·5 to 4·2) −33·6% (−38·1 to −26·5) * * Percentage changes that are statistically significant. 15 658·0 (14 051·5 to 17 506·6) −34·7% (−40·5 to −26·1) * * Percentage changes that are statistically significant. 228·7 (204·9 to 255·9) −39·4% (−44·8 to −31·4) * * Percentage changes that are statistically significant.

Protein-energy malnutrition 231·8 (212·4 to 254·2) −26·1% (−31·7 to −17·9) * * Percentage changes that are statistically significant. 3·3 (3·0 to 3·7) −34·6% (−39·4 to −27·5) * * Percentage changes that are statistically significant. 14 405·4 (12 873·5 to 16 128·0) −35·1% (−41·1 to −26·7) * * Percentage changes that are statistically significant. 211·8 (189·0 to 237·3) −39·4% (−45·0 to −31·6) * * Percentage changes that are statistically significant.

Other nutritional deficiencies 38·2 (33·7 to 44·6) −7·2% (−14·6 to 3·1) 0·5 (0·4 to 0·6) −25·8% (−31·7 to −17·5) * * Percentage changes that are statistically significant. 1252·7 (1087·5 to 1435·2) −29·2% (−36·9 to −19·7) * * Percentage changes that are statistically significant. 16·9 (14·6 to 19·5) −38·6% (−45·4 to −30·4) * * Percentage changes that are statistically significant.

Non-communicable diseases 41 071·1 (40 470·9 to 41 548·9) 22·7% (21·5 to 23·9) * * Percentage changes that are statistically significant. 536·1 (528·4 to 542·2) −7·9% (−8·8 to −7·0) * * Percentage changes that are statistically significant. 872 601·8 (859 538·6 to 884 787·7) 13·6% (12·2 to 14·9) * * Percentage changes that are statistically significant. 11 097·4 (10 928·6 to 11 253·8) −9·6% (−10·7 to −8·6) * * Percentage changes that are statistically significant.

Neoplasms 9556·2 (9395·7 to 9692·3) 25·4% (23·9 to 27·0) * * Percentage changes that are statistically significant. 121·2 (119·1 to 122·9) −4·4% (−5·6 to −3·3) * * Percentage changes that are statistically significant. 225 738·1 (221 608·8 to 229 322·4) 19·6% (17·8 to 21·4) * * Percentage changes that are statistically significant. 2803·4 (2751·5 to 2848·8) −5·6% (−7·0 to −4·1) * * Percentage changes that are statistically significant.

Lip and oral cavity cancer 193·7 (184·7 to 201·6) 35·6% (29·5 to 40·8) * * Percentage changes that are statistically significant. 2·4 (2·3 to 2·5) 4·0% (−0·6 to 8·0) 5090·6 (4819·5 to 5328·3) 30·5% (23·8 to 36·4) * * Percentage changes that are statistically significant. 62·2 (58·9 to 65·1) 3·0% (−2·3 to 7·6)

Nasopharynx cancer 69·5 (66·9 to 72·3) 24·4% (20·0 to 28·8) * * Percentage changes that are statistically significant. 0·9 (0·8 to 0·9) −3·0% (−6·4 to 0·4) 2034·5 (1954·7 to 2117·4) 18·3% (13·9 to 23·1) * * Percentage changes that are statistically significant. 24·8 (23·8 to 25·8) −5·0% (−8·5 to −1·3) * * Percentage changes that are statistically significant.

Other pharynx cancer 117·4 (102·1 to 124·5) 40·4% (29·7 to 48·4) * * Percentage changes that are statistically significant. 1·4 (1·3 to 1·5) 7·9% (−0·3 to 14·0) 3204·2 (2766·3 to 3405·1) 36·0% (25·4 to 44·2) * * Percentage changes that are statistically significant. 38·9 (33·5 to 41·3) 6·5% (−1·7 to 12·8)

Oesophageal cancer 436·0 (425·0 to 447·6) 13·0% (9·9 to 16·3) * * Percentage changes that are statistically significant. 5·5 (5·3 to 5·6) −14·5% (−16·9 to −12·0) * * Percentage changes that are statistically significant. 9647·5 (9410·7 to 9903·5) 8·9% (5·8 to 12·2) * * Percentage changes that are statistically significant. 118·3 (115·4 to 121·4) −16·2% (−18·6 to −13·7) * * Percentage changes that are statistically significant.

Stomach cancer 865·0 (848·3 to 884·7) 9·4% (7·1 to 12·1) * * Percentage changes that are statistically significant. 11·0 (10·8 to 11·2) −17·1% (−18·8 to −15·1) * * Percentage changes that are statistically significant. 18 782·0 (18 409·7 to 19 207·7) 4·8% (2·4 to 7·4) * * Percentage changes that are statistically significant. 231·6 (227·0 to 236·8) −18·6% (−20·5 to −16·6) * * Percentage changes that are statistically significant.

Colon and rectum cancer 896·0 (876·3 to 915·7) 27·8% (24·0 to 31·3) * * Percentage changes that are statistically significant. 11·5 (11·3 to 11·8) −4·3% (−7·1 to −1·8) * * Percentage changes that are statistically significant. 18 106·7 (17 678·0 to 18 525·0) 23·8% (19·2 to 27·6) * * Percentage changes that are statistically significant. 224·7 (219·4 to 229·9) −4·5% (−8·0 to −1·7) * * Percentage changes that are statistically significant.

Liver cancer 819·4 (789·7 to 855·5) 27·0% (23·0 to 32·9) * * Percentage changes that are statistically significant. 10·2 (9·8 to 10·7) −2·5% (−5·6 to 2·0) 20 536·2 (19 678·7 to 21 551·9) 21·2% (17·0 to 27·4) * * Percentage changes that are statistically significant. 250·7 (240·4 to 263·0) −4·6% (−8·0 to 0·1)

Liver cancer due to hepatitis B 325·4 (304·6 to 348·2) 20·3% (15·3 to 28·2) * * Percentage changes that are statistically significant. 4·0 (3·7 to 4·3) −6·2% (−10·0 to 0·1) 9449·0 (8837·3 to 10 138·6) 14·7% (9·7 to 21·9) * * Percentage changes that are statistically significant. 114·6 (107·3 to 123·0) −8·4% (−12·2 to −2·6) * * Percentage changes that are statistically significant.

Liver cancer due to hepatitis C 234·3 (219·4 to 250·6) 30·4% (26·7 to 35·0) * * Percentage changes that are statistically significant. 3·0 (2·8 to 3·2) −2·1% (−4·9 to 1·4) 4898·4 (4554·0 to 5259·3) 26·9% (23·3 to 31·6) * * Percentage changes that are statistically significant. 60·3 (56·2 to 64·7) −3·0% (−5·8 to 0·5)

Liver cancer due to alcohol use 129·3 (114·5 to 147·3) 31·7% (26·8 to 37·3) * * Percentage changes that are statistically significant. 1·6 (1·4 to 1·8) 0·6% (−3·0 to 4·8) 3040·7 (2647·6 to 3549·8) 27·8% (22·4 to 33·9) * * Percentage changes that are statistically significant. 37·2 (32·5 to 43·3) −0·6% (−4·5 to 3·9)

Liver cancer due to NASH 66·9 (59·6 to 74·5) 42·3% (38·0 to 47·6) * * Percentage changes that are statistically significant. 0·8 (0·8 to 0·9) 7·6% (4·4 to 11·7) * * Percentage changes that are statistically significant. 1443·8 (1288·9 to 1605·9) 37·3% (32·7 to 42·8) * * Percentage changes that are statistically significant. 17·8 (15·9 to 19·7) 6·3% (2·9 to 10·5) * * Percentage changes that are statistically significant.

Liver cancer due to other causes 63·5 (57·4 to 70·6) 28·2% (23·6 to 34·3) * * Percentage changes that are statistically significant. 0·8 (0·7 to 0·9) −0·9% (−4·2 to 3·6) 1704·2 (1528·4 to 1903·8) 21·1% (16·0 to 27·4) * * Percentage changes that are statistically significant. 20·9 (18·8 to 23·3) −3·5% (−7·2 to 1·4)

Gallbladder and biliary tract cancer 174·0 (154·2 to 184·9) 25·0% (21·5 to 28·7) * * Percentage changes that are statistically significant. 2·2 (2·0 to 2·4) −6·7% (−9·4 to −4·0) * * Percentage changes that are statistically significant. 3434·0 (3009·7 to 3660·0) 21·8% (17·8 to 26·3) * * Percentage changes that are statistically significant. 42·6 (37·3 to 45·4) −6·8% (−9·9 to −3·5) * * Percentage changes that are statistically significant.

Pancreatic cancer 441·1 (432·8 to 449·0) 39·9% (36·7 to 42·6) * * Percentage changes that are statistically significant. 5·6 (5·5 to 5·7) 4·8% (2·5 to 6·8) * * Percentage changes that are statistically significant. 8988·1 (8806·6 to 9162·9) 35·8% (32·5 to 38·6) * * Percentage changes that are statistically significant. 111·1 (108·9 to 113·2) 4·0% (1·5 to 6·1) * * Percentage changes that are statistically significant.

Larynx cancer 126·5 (123·4 to 129·9) 21·1% (17·8 to 24·4) * * Percentage changes that are statistically significant. 1·6 (1·5 to 1·6) −7·7% (−10·1 to −5·2) * * Percentage changes that are statistically significant. 3170·0 (3089·7 to 3260·3) 17·3% (13·9 to 20·9) * * Percentage changes that are statistically significant. 38·5 (37·6 to 39·6) −9·1% (−11·7 to −6·4) * * Percentage changes that are statistically significant.

Tracheal, bronchus, and lung cancer 1883·1 (1844·2 to 1922·8) 29·6% (26·5 to 32·5) * * Percentage changes that are statistically significant. 23·7 (23·3 to 24·2) −2·0% (−4·3 to 0·1) 40 391·6 (39 506·7 to 41 285·6) 24·8% (21·7 to 27·6) * * Percentage changes that are statistically significant. 496·4 (485·5 to 507·2) −4·1% (−6·5 to −2·0) * * Percentage changes that are statistically significant.

Malignant skin melanoma 61·7 (47·9 to 70·3) 23·6% (19·0 to 26·9) * * Percentage changes that are statistically significant. 0·8 (0·6 to 0·9) −5·1% (−8·5 to −2·5) * * Percentage changes that are statistically significant. 1513·2 (1220·7 to 1774·4) 16·1% (12·7 to 20·0) * * Percentage changes that are statistically significant. 18·7 (15·1 to 21·9) −7·2% (−9·8 to −3·8) * * Percentage changes that are statistically significant.

Non-melanoma skin cancer 65·1 (63·1 to 66·5) 38·6% (34·9 to 41·2) * * Percentage changes that are statistically significant. 0·8 (0·8 to 0·9) 2·7% (0·0 to 4·5) * * Percentage changes that are statistically significant. 1239·1 (1200·2 to 1266·6) 30·0% (26·2 to 32·7) * * Percentage changes that are statistically significant. 15·5 (15·0 to 15·8) 0·5% (−2·3 to 2·6)

Non-melanoma skin cancer (squamous-cell carcinoma) 65·1 (63·1 to 66·5) 38·6% (34·9 to 41·2) * * Percentage changes that are statistically significant. 0·8 (0·8 to 0·9) 2·7% (0·0 to 4·5) * * Percentage changes that are statistically significant. 1239·1 (1200·2 to 1266·6) 30·0% (26·2 to 32·7) * * Percentage changes that are statistically significant. 15·5 (15·0 to 15·8) 0·5% (−2·3 to 2·6)

Breast cancer 611·6 (589·2 to 640·7) 27·0% (21·3 to 31·2) * * Percentage changes that are statistically significant. 7·6 (7·4 to 8·0) −2·6% (−6·9 to 0·4) 16 400·7 (15 737·0 to 17 320·2) 23·9% (17·3 to 28·7) * * Percentage changes that are statistically significant. 200·2 (192·1 to 211·4) −1·7% (−6·8 to 2·1)

Cervical cancer 259·7 (241·1 to 269·2) 18·8% (12·9 to 22·8) * * Percentage changes that are statistically significant. 3·2 (3·0 to 3·3) −7·2% (−11·7 to −4·0) * * Percentage changes that are statistically significant. 7773·5 (7227·4 to 8087·8) 15·1% (9·4 to 19·1) * * Percentage changes that are statistically significant. 94·6 (88·1 to 98·5) −7·2% (−11·8 to −3·9) * * Percentage changes that are statistically significant.

Uterine cancer 85·2 (83·2 to 87·4) 18·8% (15·8 to 22·5) * * Percentage changes that are statistically significant. 1·1 (1·0 to 1·1) −10·4% (−12·5 to −7·7) * * Percentage changes that are statistically significant. 1930·0 (1879·9 to 1983·0) 14·8% (11·6 to 19·0) * * Percentage changes that are statistically significant. 23·7 (23·1 to 24·3) −11·2% (−13·7 to −8·0) * * Percentage changes that are statistically significant.

Ovarian cancer 176·0 (171·4 to 181·2) 30·3% (26·8 to 33·7) * * Percentage changes that are statistically significant. 2·2 (2·1 to 2·3) −1·0% (−3·6 to 1·6) 4496·9 (4370·7 to 4642·1) 29·1% (24·8 to 33·1) * * Percentage changes that are statistically significant. 54·9 (53·4 to 56·7) 1·1% (−2·2 to 4·2)

Prostate cancer 415·9 (357·3 to 489·5) 32·5% (29·3 to 38·4) * * Percentage changes that are statistically significant. 5·5 (4·7 to 6·5) −2·5% (−4·9 to 1·9) 6214·5 (5324·2 to 7293·0) 28·3% (24·9 to 34·5) * * Percentage changes that are statistically significant. 79·3 (68·1 to 93·0) −3·6% (−6·2 to 1·2)

Testicular cancer 7·7 (7·4 to 8·0) 6·1% (2·3 to 10·9) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·1) −9·4% (−12·6 to −5·2) * * Percentage changes that are statistically significant. 338·7 (323·8 to 357·4) 0·9% (−3·3 to 6·3) 4·3 (4·1 to 4·5) −10·8% (−14·5 to −6·1) * * Percentage changes that are statistically significant.

Kidney cancer 138·5 (128·7 to 142·5) 30·1% (26·2 to 34·1) * * Percentage changes that are statistically significant. 1·8 (1·6 to 1·8) −1·3% (−4·3 to 1·7) 3143·3 (2952·2 to 3234·1) 23·1% (18·5 to 27·3) * * Percentage changes that are statistically significant. 39·4 (37·0 to 40·5) −3·3% (−6·9 to 0·0)

Bladder cancer 196·5 (191·5 to 205·8) 27·8% (25·1 to 30·4) * * Percentage changes that are statistically significant. 2·6 (2·5 to 2·7) −5·4% (−7·3 to −3·4) * * Percentage changes that are statistically significant. 3350·1 (3257·4 to 3511·6) 22·6% (19·9 to 25·3) * * Percentage changes that are statistically significant. 42·2 (41·0 to 44·1) −6·9% (−8·9 to −4·8) * * Percentage changes that are statistically significant.

Brain and nervous system cancer 247·1 (213·0 to 265·0) 29·2% (23·2 to 33·4) * * Percentage changes that are statistically significant. 3·1 (2·7 to 3·3) 3·8% (−1·0 to 7·0) 8577·8 (7527·0 to 9359·3) 18·4% (11·9 to 24·6) * * Percentage changes that are statistically significant. 109·8 (96·1 to 120·0) 0·0% (−5·6 to 5·3)

Thyroid cancer 41·2 (39·9 to 44·1) 28·9% (24·3 to 33·3) * * Percentage changes that are statistically significant. 0·5 (0·5 to 0·6) −1·2% (−4·5 to 2·0) 1001·2 (963·6 to 1074·0) 22·1% (16·7 to 28·0) * * Percentage changes that are statistically significant. 12·4 (12·0 to 13·4) −2·3% (−6·6 to 2·4)

Mesothelioma 29·9 (29·1 to 30·6) 26·9% (20·1 to 32·6) * * Percentage changes that are statistically significant. 0·4 (0·4 to 0·4) −3·4% (−8·4 to 0·7) 655·7 (635·2 to 677·0) 21·0% (13·8 to 27·3) * * Percentage changes that are statistically significant. 8·1 (7·9 to 8·4) −5·4% (−10·8 to −0·8) * * Percentage changes that are statistically significant.

Hodgkin lymphoma 32·6 (27·6 to 38·1) 0·2% (−3·5 to 3·6) 0·4 (0·4 to 0·5) −16·8% (−19·8 to −14·0) * * Percentage changes that are statistically significant. 1327·6 (1110·1 to 1567·7) −5·2% (−8·6 to −1·8) * * Percentage changes that are statistically significant. 17·1 (14·3 to 20·2) −17·1% (−20·1 to −13·9) * * Percentage changes that are statistically significant.

Non-Hodgkin lymphoma 248·6 (243·5 to 253·1) 29·4% (25·5 to 32·4) * * Percentage changes that are statistically significant. 3·2 (3·1 to 3·2) 0·1% (−2·7 to 2·4) 6828·8 (6611·8 to 7020·0) 22·1% (15·6 to 26·9) * * Percentage changes that are statistically significant. 86·8 (84·0 to 89·5) 0·2% (−5·2 to 4·3)

Multiple myeloma 107·1 (98·5 to 118·9) 32·7% (28·4 to 36·4) * * Percentage changes that are statistically significant. 1·4 (1·3 to 1·5) −0·4% (−3·5 to 2·4) 2234·7 (2091·4 to 2493·2) 30·4% (25·6 to 34·4) * * Percentage changes that are statistically significant. 27·7 (25·9 to 30·8) 0·3% (−3·3 to 3·4)

Leukaemia 347·6 (317·3 to 364·9) 12·8% (9·5 to 15·6) * * Percentage changes that are statistically significant. 4·5 (4·1 to 4·7) −9·6% (−12·2 to −7·4) * * Percentage changes that are statistically significant. 11 712·0 (10 531·4 to 12 523·3) 2·3% (−3·7 to 6·2) 153·4 (137·9 to 164·5) −12·0% (−17·3 to −8·5) * * Percentage changes that are statistically significant.

Acute lymphoid leukaemia 52·2 (46·0 to 56·7) 14·1% (2·6 to 23·2) * * Percentage changes that are statistically significant. 0·7 (0·6 to 0·7) −1·5% (−11·6 to 6·2) 2661·7 (2341·7 to 2941·1) 5·3% (−8·6 to 15·4) 36·1 (31·7 to 40·0) −4·7% (−17·6 to 4·7)

Chronic lymphoid leukaemia 35·2 (33·5 to 36·9) 21·4% (17·7 to 25·0) * * Percentage changes that are statistically significant. 0·5 (0·4 to 0·5) −10·3% (−13·0 to −7·6) * * Percentage changes that are statistically significant. 634·1 (595·7 to 674·2) 18·3% (14·2 to 22·4) * * Percentage changes that are statistically significant. 8·0 (7·5 to 8·5) −9·2% (−12·3 to −6·1) * * Percentage changes that are statistically significant.

Acute myeloid leukaemia 99·9 (91·3 to 104·6) 24·6% (17·1 to 29·8) * * Percentage changes that are statistically significant. 1·3 (1·2 to 1·3) −1·0% (−6·6 to 3·0) 3192·6 (2868·8 to 3405·6) 16·2% (4·4 to 24·6) * * Percentage changes that are statistically significant. 41·3 (37·0 to 44·1) −1·4% (−11·3 to 5·8)

Chronic myeloid leukaemia 24·1 (22·2 to 26·1) 3·3% (0·4 to 6·4) * * Percentage changes that are statistically significant. 0·3 (0·3 to 0·3) −19·9% (−22·2 to −17·6) * * Percentage changes that are statistically significant. 643·3 (583·4 to 699·1) −1·7% (−5·2 to 1·5) 8·0 (7·3 to 8·7) −19·7% (−22·4 to −17·1) * * Percentage changes that are statistically significant.

Other leukaemia 136·2 (121·0 to 146·8) 4·9% (0·9 to 9·7) * * Percentage changes that are statistically significant. 1·8 (1·6 to 1·9) −15·6% (−18·7 to −12·1) * * Percentage changes that are statistically significant. 4580·2 (3955·1 to 5013·3) −8·1% (−14·6 to −1·8) * * Percentage changes that are statistically significant. 60·0 (51·9 to 65·7) −20·8% (−26·5 to −15·4) * * Percentage changes that are statistically significant.

Other malignant cancers 359·5 (331·4 to 370·8) 26·8% (23·3 to 29·5) * * Percentage changes that are statistically significant. 4·6 (4·2 to 4·8) 0·1% (−2·6 to 2·2) 11 189·0 (10 386·5 to 11 664·8) 18·4% (12·8 to 22·8) * * Percentage changes that are statistically significant. 144·4 (133·8 to 150·9) −0·3% (−5·1 to 3·5)

Other neoplasms 102·9 (80·2 to 122·4) 42·0% (35·6 to 51·7) * * Percentage changes that are statistically significant. 1·3 (1·0 to 1·6) 7·4% (2·1 to 15·8) * * Percentage changes that are statistically significant. 2425·8 (2024·4 to 2932·1) 32·9% (25·9 to 42·7) * * Percentage changes that are statistically significant. 31·1 (25·9 to 37·4) 7·9% (2·0 to 16·5) * * Percentage changes that are statistically significant.

Myelodysplastic, myeloproliferative, and other haemopoietic neoplasms 98·8 (76·7 to 118·1) 42·6% (36·2 to 52·2) * * Percentage changes that are statistically significant. 1·3 (1·0 to 1·5) 7·1% (1·8 to 15·3) * * Percentage changes that are statistically significant. 2189·1 (1820·8 to 2665·5) 33·9% (26·6 to 43·3) * * Percentage changes that are statistically significant. 27·9 (23·2 to 33·8) 7·2% (1·2 to 15·6) * * Percentage changes that are statistically significant.

Other benign and in-situ neoplasms 4·1 (3·2 to 4·8) 29·6% (17·2 to 44·5) * * Percentage changes that are statistically significant. 0·1 (0·0 to 0·1) 15·5% (4·1 to 29·2) * * Percentage changes that are statistically significant. 236·8 (186·4 to 277·7) 25·0% (12·7 to 38·6) * * Percentage changes that are statistically significant. 3·2 (2·5 to 3·7) 14·3% (3·0 to 27·0) * * Percentage changes that are statistically significant.

Cardiovascular diseases 17 790·9 (17 527·1 to 18 042·7) 21·1% (19·7 to 22·6) * * Percentage changes that are statistically significant. 233·1 (229·7 to 236·4) −10·3% (−11·4 to −9·3) * * Percentage changes that are statistically significant. 330 172·6 (324 899·3 to 335 159·9) 14·7% (13·3 to 16·2) * * Percentage changes that are statistically significant. 4148·0 (4082·0 to 4210·8) −11·3% (−12·4 to −10·1) * * Percentage changes that are statistically significant.

Rheumatic heart disease 285·5 (266·2 to 303·3) 1·3% (−3·9 to 6·0) 3·7 (3·4 to 3·9) −21·3% (−25·2 to −17·8) * * Percentage changes that are statistically significant. 7492·6 (6926·7 to 8046·7) −10·2% (−15·4 to −6·2) * * Percentage changes that are statistically significant. 94·5 (87·5 to 101·4) −25·9% (−30·0 to −22·7) * * Percentage changes that are statistically significant.

Ischaemic heart disease 8930·4 (8790·7 to 9138·7) 22·3% (20·6 to 23·8) * * Percentage changes that are statistically significant. 116·9 (115·1 to 119·7) −9·7% (−11·0 to −8·7) * * Percentage changes that are statistically significant. 164 983·4 (162 168·9 to 168 584·2) 17·3% (15·4 to 19·0) * * Percentage changes that are statistically significant. 2065·9 (2030·6 to 2111·7) −9·8% (−11·2 to −8·5) * * Percentage changes that are statistically significant.

Stroke 6167·3 (6044·3 to 6327·6) 16·6% (14·7 to 18·6) * * Percentage changes that are statistically significant. 80·5 (78·9 to 82·6) −13·6% (−15·0 to −12·1) * * Percentage changes that are statistically significant. 113 355·9 (110 957·8 to 116 180·6) 12·1% (9·9 to 14·1) * * Percentage changes that are statistically significant. 1422·2 (1392·0 to 1457·7) −13·8% (−15·5 to −12·3) * * Percentage changes that are statistically significant.

Ischaemic stroke 2747·4 (2657·1 to 2857·6) 21·2% (19·0 to 23·3) * * Percentage changes that are statistically significant. 36·6 (35·5 to 38·0) −11·8% (−13·4 to −10·3) * * Percentage changes that are statistically significant. 40 834·1 (39 133·3 to 43 140·9) 16·9% (14·3 to 19·3) * * Percentage changes that are statistically significant. 521·8 (500·5 to 550·2) −12·0% (−13·9 to −10·3) * * Percentage changes that are statistically significant.

Intracerebral haemorrhage 2974·9 (2880·8 to 3072·8) 12·5% (9·6 to 15·1) * * Percentage changes that are statistically significant. 38·2 (37·0 to 39·4) −15·7% (−17·8 to −13·8) * * Percentage changes that are statistically significant. 61 562·6 (59 598·2 to 63 531·4) 9·3% (6·5 to 11·8) * * Percentage changes that are statistically significant. 764·1 (739·7 to 788·4) −15·4% (−17·6 to −13·5) * * Percentage changes that are statistically significant.

Subarachnoid haemorrhage 445·0 (417·2 to 492·3) 18·4% (13·4 to 24·6) * * Percentage changes that are statistically significant. 5·7 (5·3 to 6·3) −9·4% (−13·1 to −4·9) * * Percentage changes that are statistically significant. 10 959·3 (10 294·3 to 12 264·1) 10·7% (6·8 to 16·5) * * Percentage changes that are statistically significant. 136·4 (128·2 to 152·5) −11·4% (−14·5 to −7·0) * * Percentage changes that are statistically significant.

Hypertensive heart disease 925·7 (681·4 to 994·9) 46·6% (26·3 to 59·3) * * Percentage changes that are statistically significant. 12·3 (9·0 to 13·2) 7·5% (−7·3 to 16·3) 15 135·2 (11 349·8 to 16 311·7) 35·7% (19·1 to 47·9) * * Percentage changes that are statistically significant. 191·5 (143·3 to 206·2) 3·8% (−8·8 to 12·9)

Non-rheumatic valvular heart disease 144·9 (121·8 to 150·4) 31·8% (27·7 to 34·7) * * Percentage changes that are statistically significant. 2·0 (1·6 to 2·0) −5·3% (−7·9 to −3·2) * * Percentage changes that are statistically significant. 2168·4 (1980·3 to 2322·7) 21·8% (18·6 to 25·0) * * Percentage changes that are statistically significant. 27·9 (25·4 to 29·6) −6·2% (−8·5 to −3·8) * * Percentage changes that are statistically significant.

Non-rheumatic calcific aortic valve disease 102·7 (82·7 to 108·0) 40·0% (33·0 to 44·9) * * Percentage changes that are statistically significant. 1·4 (1·1 to 1·5) −1·0% (−5·6 to 2·2) 1345·1 (1185·5 to 1432·5) 30·4% (25·1 to 35·3) * * Percentage changes that are statistically significant. 17·5 (15·3 to 18·6) −1·7% (−5·3 to 1·6)

Non-rheumatic degenerative mitral valve disease 35·7 (30·5 to 42·5) 16·4% (11·0 to 23·4) * * Percentage changes that are statistically significant. 0·5 (0·4 to 0·6) −14·0% (−18·1 to −8·6) * * Percentage changes that are statistically significant. 683·6 (592·6 to 787·0) 10·3% (4·9 to 16·2) * * Percentage changes that are statistically significant. 8·7 (7·5 to 10·0) −13·0% (−16·9 to −8·3) * * Percentage changes that are statistically significant.

Other non-rheumatic valve diseases 6·4 (4·9 to 8·7) 9·7% (−4·1 to 42·2) 0·1 (0·1 to 0·1) −17·8% (−28·5 to 8·0) 139·7 (105·8 to 187·5) 8·1% (−2·4 to 27·6) 1·8 (1·4 to 2·4) −12·4% (−21·3 to 4·7)

Cardiomyopathy and myocarditis 368·5 (341·9 to 386·9) 8·1% (3·8 to 18·2) * * Percentage changes that are statistically significant. 4·8 (4·5 to 5·0) −16·6% (−19·8 to −9·4) * * Percentage changes that are statistically significant. 9623·3 (8867·5 to 10 208·8) −5·1% (−9·6 to 5·5) 122·4 (113·0 to 129·7) −21·5% (−25·1 to −13·0) * * Percentage changes that are statistically significant.

Myocarditis 46·5 (39·7 to 51·8) 14·4% (5·6 to 29·7) * * Percentage changes that are statistically significant. 0·6 (0·5 to 0·7) −13·3% (−20·4 to −0·1) * * Percentage changes that are statistically significant. 1259·3 (1100·1 to 1415·5) −0·3% (−6·9 to 7·6) 16·6 (14·5 to 18·5) −15·2% (−21·1 to −7·7) * * Percentage changes that are statistically significant.

Alcoholic cardiomyopathy 88·9 (80·9 to 96·3) −25·3% (−29·5 to −8·3) * * Percentage changes that are statistically significant. 1·1 (1·0 to 1·2) −40·5% (−43·7 to −27·6) * * Percentage changes that are statistically significant. 2849·2 (2599·0 to 3073·1) −30·7% (−34·7 to −12·1) * * Percentage changes that are statistically significant. 34·7 (31·7 to 37·5) −43·2% (−46·5 to −28·2) * * Percentage changes that are statistically significant.

Other cardiomyopathy 233·2 (213·7 to 248·3) 28·5% (24·5 to 32·4) * * Percentage changes that are statistically significant. 3·1 (2·8 to 3·3) −3·6% (−6·7 to −0·7) * * Percentage changes that are statistically significant. 5514·8 (4946·7 to 5992·9) 15·7% (10·9 to 19·9) * * Percentage changes that are statistically significant. 71·1 (64·0 to 77·0) −5·4% (−9·3 to −2·0) * * Percentage changes that are statistically significant.

Atrial fibrillation and flutter 287·2 (276·4 to 304·8) 47·8% (45·4 to 50·6) * * Percentage changes that are statistically significant. 4·0 (3·9 to 4·2) 2·6% (0·9 to 4·6) * * Percentage changes that are statistically significant. 3054·5 (2923·0 to 3235·4) 40·5% (37·9 to 43·4) * * Percentage changes that are statistically significant. 40·6 (38·9 to 43·1) 2·2% (0·3 to 4·2) * * Percentage changes that are statistically significant.

Aortic aneurysm 167·2 (159·8 to 174·1) 23·7% (19·9 to 27·6) * * Percentage changes that are statistically significant. 2·2 (2·1 to 2·3) −8·5% (−11·2 to −5·8) * * Percentage changes that are statistically significant. 3039·9 (2877·2 to 3186·4) 19·0% (14·5 to 23·6) * * Percentage changes that are statistically significant. 38·2 (36·2 to 40·0) −8·5% (−11·9 to −5·1) * * Percentage changes that are statistically significant.

Peripheral vascular disease 70·2 (43·2 to 123·3) 55·7% (31·0 to 74·2) * * Percentage changes that are statistically significant. 1·0 (0·6 to 1·7) 10·5% (−6·8 to 24·1) 916·9 (576·9 to 1540·0) 48·3% (25·0 to 65·6) * * Percentage changes that are statistically significant. 11·8 (7·4 to 20·0) 9·7% (−7·5 to 22·6)

Endocarditis 83·4 (74·3 to 94·3) 32·2% (25·2 to 36·8) * * Percentage changes that are statistically significant. 1·1 (1·0 to 1·2) 1·0% (−4·0 to 5·0) 2174·5 (2033·2 to 2373·0) 16·9% (8·9 to 22·2) * * Percentage changes that are statistically significant. 28·3 (26·4 to 30·9) −2·3% (−8·8 to 2·1)

Other cardiovascular and circulatory diseases 360·7 (338·1 to 392·9) 21·9% (17·9 to 24·8) * * Percentage changes that are statistically significant. 4·7 (4·4 to 5·1) −7·9% (−10·9 to −5·9) * * Percentage changes that are statistically significant. 8228·0 (7681·4 to 9061·9) 12·6% (9·5 to 15·7) * * Percentage changes that are statistically significant. 104·7 (97·8 to 115·2) −9·4% (−12·0 to −7·1) * * Percentage changes that are statistically significant.

Chronic respiratory diseases 3914·2 (3790·6 to 4044·8) 15·8% (12·7 to 19·3) * * Percentage changes that are statistically significant. 51·4 (49·7 to 53·1) −14·2% (−16·5 to −11·5) * * Percentage changes that are statistically significant. 68 004·9 (65 869·4 to 70 592·2) 9·7% (7·0 to 13·2) * * Percentage changes that are statistically significant. 861·9 (835·4 to 895·0) −15·7% (−17·7 to −13·0) * * Percentage changes that are statistically significant.

Chronic obstructive pulmonary disease 3197·8 (3029·0 to 3358·9) 17·5% (13·3 to 21·1) * * Percentage changes that are statistically significant. 42·2 (40·0 to 44·2) −13·6% (−16·5 to −11·0) * * Percentage changes that are statistically significant. 50 990·0 (47 678·7 to 54 146·9) 13·2% (8·8 to 16·9) * * Percentage changes that are statistically significant. 647·3 (605·9 to 686·4) −14·3% (−17·5 to −11·6) * * Percentage changes that are statistically significant.

Pneumoconiosis 21·6 (20·5 to 22·7) 10·7% (5·1 to 16·6) * * Percentage changes that are statistically significant. 0·3 (0·3 to 0·3) −16·7% (−20·8 to −12·4) * * Percentage changes that are statistically significant. 426·9 (403·6 to 452·9) 7·9% (1·8 to 14·6) * * Percentage changes that are statistically significant. 5·3 (5·0 to 5·6) −16·4% (−21·1 to −11·3) * * Percentage changes that are statistically significant.

Silicosis 11·3 (10·4 to 12·5) 12·0% (1·2 to 22·8) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·2) −15·5% (−23·6 to −7·4) * * Percentage changes that are statistically significant. 235·7 (210·3 to 258·2) 11·8% (−0·7 to 23·6) 2·9 (2·6 to 3·2) −13·4% (−23·1 to −4·3) * * Percentage changes that are statistically significant.

Asbestosis 3·4 (2·3 to 3·9) 23·3% (15·1 to 33·9) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·1) −8·3% (−14·1 to −0·4) * * Percentage changes that are statistically significant. 54·6 (38·6 to 65·6) 15·6% (7·4 to 28·5) * * Percentage changes that are statistically significant. 0·7 (0·5 to 0·8) −11·4% (−17·5 to −1·3) * * Percentage changes that are statistically significant.

Coal worker pneumoconiosis 3·2 (2·9 to 4·0) −2·2% (−12·0 to 11·7) 0·0 (0·0 to 0·1) −26·6% (−33·8 to −16·7) * * Percentage changes that are statistically significant. 58·9 (52·2 to 76·4) −6·4% (−16·3 to 8·3) 0·7 (0·7 to 1·0) −27·9% (−35·4 to −16·9) * * Percentage changes that are statistically significant.

Other pneumoconiosis 3·6 (3·1 to 4·5) 8·9% (0·0 to 25·4) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·1) −17·5% (−24·1 to −5·0) * * Percentage changes that are statistically significant. 77·6 (66·1 to 96·4) 4·2% (−3·8 to 19·5) 1·0 (0·8 to 1·2) −18·3% (−24·7 to −5·9) * * Percentage changes that are statistically significant.

Asthma 495·1 (338·2 to 641·2) −0·7% (−6·2 to 8·1) 6·3 (4·3 to 8·2) −23·9% (−28·1 to −17·2) * * Percentage changes that are statistically significant. 12 139·9 (8538·5 to 15 576·3) −7·5% (−11·4 to −1·6) * * Percentage changes that are statistically significant. 152·8 (108·3 to 195·8) −25·8% (−28·9 to −20·4) * * Percentage changes that are statistically significant.

Interstitial lung disease and pulmonary sarcoidosis 147·6 (114·9 to 181·3) 49·8% (39·0 to 58·6) * * Percentage changes that are statistically significant. 1·9 (1·5 to 2·4) 11·4% (4·0 to 17·9) * * Percentage changes that are statistically significant. 2716·7 (2156·9 to 3371·3) 43·0% (32·1 to 53·4) * * Percentage changes that are statistically significant. 34·2 (27·1 to 42·4) 10·4% (2·3 to 18·6) * * Percentage changes that are statistically significant.

Other chronic respiratory diseases 52·1 (45·9 to 59·6) 21·3% (14·1 to 34·2) * * Percentage changes that are statistically significant. 0·7 (0·6 to 0·8) −3·2% (−8·7 to 6·7) 1731·4 (1504·5 to 1998·9) 10·8% (3·2 to 24·3) * * Percentage changes that are statistically significant. 22·1 (19·3 to 25·5) −6·3% (−12·6 to 5·3)

Digestive diseases 2377·7 (2295·1 to 2518·0) 15·3% (12·1 to 19·7) * * Percentage changes that are statistically significant. 30·3 (29·2 to 32·1) −10·7% (−13·1 to −7·3) * * Percentage changes that are statistically significant. 65 348·4 (62 343·9 to 69 371·3) 7·5% (4·2 to 11·9) * * Percentage changes that are statistically significant. 819·8 (781·7 to 869·7) −12·2% (−14·9 to −8·5) * * Percentage changes that are statistically significant.

Cirrhosis and other chronic liver diseases 1322·9 (1268·2 to 1449·1) 15·0% (8·7 to 21·5) * * Percentage changes that are statistically significant. 16·5 (15·8 to 18·1) −9·7% (−14·7 to −4·6) * * Percentage changes that are statistically significant. 39 652·4 (37 985·2 to 43 624·9) 8·9% (3·4 to 14·4) * * Percentage changes that are statistically significant. 488·9 (468·0 to 537·5) −11·3% (−15·8 to −6·9) * * Percentage changes that are statistically significant.

Cirrhosis and other chronic liver diseases due to hepatitis B 384·0 (349·1 to 441·7) 8·6% (1·1 to 17·3) * * Percentage changes that are statistically significant. 4·8 (4·3 to 5·5) −14·3% (−20·2 to −7·3) * * Percentage changes that are statistically significant. 11 721·5 (10 648·0 to 13 431·7) 3·4% (−3·3 to 10·7) 144·1 (130·8 to 165·3) −15·5% (−20·9 to −9·5) * * Percentage changes that are statistically significant.

Cirrhosis and other chronic liver diseases due to hepatitis C 342·2 (312·6 to 381·1) 17·4% (11·3 to 23·0) * * Percentage changes that are statistically significant. 4·2 (3·9 to 4·7) −8·4% (−13·0 to −3·9) * * Percentage changes that are statistically significant. 9980·1 (9074·7 to 11 116·9) 12·2% (6·8 to 17·3) * * Percentage changes that are statistically significant. 121·9 (111·0 to 135·8) −9·6% (−13·9 to −5·5) * * Percentage changes that are statistically significant.

Cirrhosis and other chronic liver diseases due to alcohol use 332·3 (303·0 to 373·3) 16·9% (11·2 to 23·7) * * Percentage changes that are statistically significant. 4·1 (3·7 to 4·6) −8·8% (−13·2 to −3·4) * * Percentage changes that are statistically significant. 9785·4 (8919·3 to 10 962·1) 12·3% (7·1 to 18·3) * * Percentage changes that are statistically significant. 119·0 (108·6 to 133·5) −10·0% (−14·2 to −5·2) * * Percentage changes that are statistically significant.

Cirrhosis due to NASH 118·0 (108·6 to 128·6) 27·6% (21·2 to 33·3) * * Percentage changes that are statistically significant. 1·5 (1·3 to 1·6) −1·4% (−6·3 to 3·1) 3285·5 (3011·9 to 3586·8) 22·2% (16·6 to 27·2) * * Percentage changes that are statistically significant. 40·0 (36·6 to 43·6) −3·0% (−7·4 to 1·0)

Cirrhosis and other chronic liver diseases due to other causes 146·4 (130·9 to 164·6) 14·2% (8·2 to 20·2) * * Percentage changes that are statistically significant. 1·9 (1·7 to 2·1) −8·6% (−13·4 to −3·8) * * Percentage changes that are statistically significant. 4880·0 (4392·5 to 5457·1) 2·1% (−4·3 to 10·7) 63·9 (57·5 to 71·4) −12·0% (−17·5 to −4·5) * * Percentage changes that are statistically significant.

Upper digestive system diseases 292·1 (279·7 to 312·3) 2·9% (−1·3 to 8·6) 3·8 (3·6 to 4·0) −21·6% (−24·8 to −17·3) * * Percentage changes that are statistically significant. 6789·9 (6413·1 to 7259·0) −4·5% (−9·5 to 1·8) 85·2 (80·4 to 91·2) −23·3% (−27·3 to −18·4) * * Percentage changes that are statistically significant.

Peptic ulcer disease 240·3 (229·4 to 258·8) 0·6% (−3·6 to 5·6) 3·1 (3·0 to 3·3) −23·5% (−26·6 to −19·7) * * Percentage changes that are statistically significant. 5513·3 (5202·4 to 5947·8) −6·8% (−11·4 to −1·5) * * Percentage changes that are statistically significant. 69·1 (65·1 to 74·7) −25·4% (−29·0 to −21·0) * * Percentage changes that are statistically significant.

Gastritis and duodenitis 51·8 (43·0 to 56·9) 15·5% (7·5 to 28·9) * * Percentage changes that are statistically significant. 0·7 (0·6 to 0·7) −11·7% (−17·6 to −2·2) * * Percentage changes that are statistically significant. 1276·6 (1047·1 to 1419·7) 6·8% (−3·1 to 22·4) 16·1 (13·2 to 17·9) −13·2% (−21·1 to −1·3) * * Percentage changes that are statistically significant.

Appendicitis 43·9 (40·2 to 47·5) 1·8% (−4·0 to 9·6) 0·6 (0·5 to 0·6) −17·0% (−21·5 to −10·7) * * Percentage changes that are statistically significant. 1633·2 (1473·2 to 1772·7) −8·7% (−16·7 to 0·6) 21·4 (19·3 to 23·3) −20·1% (−27·2 to −12·1) * * Percentage changes that are statistically significant.

Paralytic ileus and intestinal obstruction 240·5 (198·7 to 261·6) 21·1% (14·4 to 29·0) * * Percentage changes that are statistically significant. 3·2 (2·7 to 3·5) −5·8% (−11·0 to 0·3) 7245·9 (5866·8 to 7980·6) 6·5% (−3·1 to 15·5) 97·0 (78·9 to 106·8) −8·7% (−16·8 to −0·8) * * Percentage changes that are statistically significant.

Inguinal, femoral, and abdominal hernia 44·2 (38·6 to 50·0) 21·7% (16·2 to 28·4) * * Percentage changes that are statistically significant. 0·6 (0·5 to 0·7) −8·9% (−12·9 to −4·2) * * Percentage changes that are statistically significant. 914·3 (792·8 to 1021·9) 12·1% (4·5 to 20·4) * * Percentage changes that are statistically significant. 11·7 (10·1 to 13·1) −10·6% (−16·5 to −3·9) * * Percentage changes that are statistically significant.

Inflammatory bowel disease 38·6 (31·6 to 41·2) 20·4% (11·5 to 27·2) * * Percentage changes that are statistically significant. 0·5 (0·4 to 0·5) −10·5% (−16·0 to −5·9) * * Percentage changes that are statistically significant. 829·7 (711·4 to 900·7) 10·3% (−2·7 to 19·5) 10·7 (9·1 to 11·7) −11·3% (−20·7 to −4·5) * * Percentage changes that are statistically significant.

Vascular intestinal disorders 96·1 (89·0 to 100·8) 22·6% (17·0 to 28·1) * * Percentage changes that are statistically significant. 1·3 (1·2 to 1·3) −10·2% (−14·2 to −6·2) * * Percentage changes that are statistically significant. 1570·1 (1433·3 to 1667·3) 17·6% (10·7 to 24·8) * * Percentage changes that are statistically significant. 20·0 (18·3 to 21·3) −10·0% (−15·3 to −5·0) * * Percentage changes that are statistically significant.

Gallbladder and biliary diseases 110·5 (105·5 to 116·6) 28·8% (25·3 to 33·8) * * Percentage changes that are statistically significant. 1·5 (1·4 to 1·6) −5·0% (−7·5 to −1·7) * * Percentage changes that are statistically significant. 1983·2 (1863·2 to 2092·0) 18·5% (13·4 to 25·3) * * Percentage changes that are statistically significant. 25·4 (23·8 to 26·8) −6·9% (−10·9 to −1·8) * * Percentage changes that are statistically significant.

Pancreatitis 101·6 (89·5 to 108·3) 20·6% (16·4 to 25·7) * * Percentage changes that are statistically significant. 1·3 (1·1 to 1·4) −5·7% (−9·0 to −1·7) * * Percentage changes that are statistically significant. 2890·0 (2537·1 to 3102·9) 13·8% (8·7 to 19·5) * * Percentage changes that are statistically significant. 35·8 (31·4 to 38·4) −6·8% (−10·9 to −2·1) * * Percentage changes that are statistically significant.

Other digestive diseases 87·3 (81·9 to 93·3) 25·4% (18·1 to 32·3) * * Percentage changes that are statistically significant. 1·2 (1·1 to 1·2) −7·1% (−12·1 to −2·4) * * Percentage changes that are statistically significant. 1839·7 (1663·9 to 2038·5) 16·4% (5·8 to 27·4) * * Percentage changes that are statistically significant. 23·7 (21·5 to 26·3) −6·5% (−14·9 to 1·8)

Neurological disorders 3094·2 (3039·6 to 3142·6) 42·1% (40·2 to 43·9) * * Percentage changes that are statistically significant. 43·1 (42·3 to 43·7) 0·1% (−1·2 to 1·3) 38 004·5 (37 134·8 to 39 174·6) 26·2% (23·9 to 30·2) * * Percentage changes that are statistically significant. 507·6 (496·1 to 523·4) −3·1% (−4·8 to −0·1) * * Percentage changes that are statistically significant.

Alzheimer's disease and other dementias 2514·6 (2470·5 to 2550·3) 46·2% (43·9 to 48·0) * * Percentage changes that are statistically significant. 35·4 (34·8 to 35·9) 0·6% (−0·9 to 1·8) 23 951·1 (23 523·6 to 24 326·8) 38·6% (35·7 to 40·9) * * Percentage changes that are statistically significant. 323·7 (317·9 to 328·7) −0·3% (−2·3 to 1·2)

Parkinson's disease 340·6 (324·4 to 355·1) 38·3% (33·3 to 41·4) * * Percentage changes that are statistically significant. 4·6 (4·4 to 4·8) 0·8% (−2·8 to 3·0) 4361·2 (4182·8 to 4578·7) 33·8% (28·5 to 37·0) * * Percentage changes that are statistically significant. 56·9 (54·5 to 59·8) 0·3% (−3·6 to 2·6)

Epilepsy 130·2 (117·0 to 150·8) 3·8% (−1·6 to 15·7) 1·7 (1·5 to 2·0) −10·7% (−15·4 to −0·5) * * Percentage changes that are statistically significant. 6232·1 (5709·8 to 7289·7) −5·5% (−11·6 to 8·3) 82·6 (75·5 to 96·6) −14·9% (−20·6 to −2·1) * * Percentage changes that are statistically significant.

Multiple sclerosis 20·7 (17·7 to 22·2) 22·4% (8·0 to 27·8) * * Percentage changes that are statistically significant. 0·3 (0·2 to 0·3) −3·9% (−14·5 to 0·4) 628·2 (563·0 to 682·4) 17·1% (4·1 to 24·5) * * Percentage changes that are statistically significant. 7·7 (6·9 to 8·3) −5·5% (−15·1 to 0·6)

Motor neuron disease 34·1 (32·8 to 37·1) 32·7% (28·0 to 37·0) * * Percentage changes that are statistically significant. 0·4 (0·4 to 0·5) 1·2% (−2·4 to 4·5) 828·1 (796·7 to 917·1) 27·2% (22·6 to 31·3) * * Percentage changes that are statistically significant. 10·3 (9·9 to 11·4) 0·1% (−3·5 to 3·3)

Other neurological disorders 53·9 (51·6 to 59·0) 25·4% (17·8 to 32·3) * * Percentage changes that are statistically significant. 0·7 (0·7 to 0·8) 2·0% (−3·9 to 6·8) 2003·8 (1856·8 to 2269·5) 11·4% (3·6 to 21·1) * * Percentage changes that are statistically significant. 26·5 (24·3 to 30·1) −2·8% (−9·3 to 5·1)

Mental disorders 0·3 (0·3 to 0·4) 19·9% (10·0 to 29·2) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) 7·5% (−1·4 to 15·9) 17·5 (15·9 to 19·2) 18·5% (8·8 to 27·5) * * Percentage changes that are statistically significant. 0·2 (0·2 to 0·2) 7·2% (−1·6 to 15·3)

Eating disorders 0·3 (0·3 to 0·4) 19·9% (10·0 to 29·2) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) 7·5% (−1·4 to 15·9) 17·5 (15·9 to 19·2) 18·5% (8·8 to 27·5) * * Percentage changes that are statistically significant. 0·2 (0·2 to 0·2) 7·2% (−1·6 to 15·3)

Anorexia nervosa 0·2 (0·2 to 0·3) 17·6% (7·0 to 27·6) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) 5·5% (−4·1 to 14·4) 12·7 (10·9 to 14·1) 15·9% (5·6 to 25·6) * * Percentage changes that are statistically significant. 0·2 (0·1 to 0·2) 5·0% (−4·4 to 13·7)

Bulimia nervosa 0·1 (0·1 to 0·1) 26·4% (12·9 to 40·5) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) 13·5% (1·0 to 26·2) * * Percentage changes that are statistically significant. 4·8 (4·0 to 6·7) 25·9% (12·0 to 40·0) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·1) 13·6% (1·1 to 26·3) * * Percentage changes that are statistically significant.

Substance use disorders 351·5 (334·1 to 362·7) 23·8% (20·2 to 27·3) * * Percentage changes that are statistically significant. 4·3 (4·1 to 4·5) 2·0% (−1·0 to 5·0) 13 597·6 (12 979·5 to 14 033·3) 18·8% (15·3 to 22·4) * * Percentage changes that are statistically significant. 168·0 (160·4 to 173·3) 0·8% (−2·2 to 3·9)

Alcohol use disorders 184·9 (166·7 to 193·0) 2·7% (−2·2 to 7·7) 2·3 (2·0 to 2·4) −16·5% (−20·4 to −12·4) * * Percentage changes that are statistically significant. 6750·4 (6113·2 to 7082·7) −2·1% (−7·2 to 3·3) 82·4 (74·7 to 86·5) −18·4% (−22·7 to −13·9) * * Percentage changes that are statistically significant.

Drug use disorders 166·6 (163·4 to 170·3) 60·2% (56·9 to 63·6) * * Percentage changes that are statistically significant. 2·1 (2·0 to 2·1) 34·1% (31·4 to 36·9) * * Percentage changes that are statistically significant. 6847·2 (6704·5 to 7004·4) 50·4% (47·0 to 54·0) * * Percentage changes that are statistically significant. 85·5 (83·7 to 87·5) 30·5% (27·6 to 33·5) * * Percentage changes that are statistically significant.

Opioid use disorders 109·5 (105·7 to 113·6) 77·0% (68·8 to 88·5) * * Percentage changes that are statistically significant. 1·4 (1·3 to 1·4) 49·4% (42·5 to 59·2) * * Percentage changes that are statistically significant. 4641·2 (4480·6 to 4818·9) 65·0% (57·3 to 75·0) * * Percentage changes that are statistically significant. 58·0 (56·1 to 60·3) 43·9% (37·1 to 52·6) * * Percentage changes that are statistically significant.

Cocaine use disorders 7·3 (6·6 to 8·1) 42·2% (30·1 to 58·3) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·1) 19·6% (9·2 to 33·0) * * Percentage changes that are statistically significant. 311·5 (281·5 to 344·1) 35·6% (24·0 to 51·2) * * Percentage changes that are statistically significant. 3·9 (3·5 to 4·3) 16·7% (6·5 to 30·0) * * Percentage changes that are statistically significant.

Amphetamine use disorders 4·5 (3·3 to 5·0) 27·2% (0·8 to 41·0) * * Percentage changes that are statistically significant. 0·1 (0·0 to 0·1) 8·7% (−14·0 to 20·7) 206·9 (151·6 to 227·8) 21·0% (−3·6 to 34·4) 2·6 (1·9 to 2·8) 5·6% (−15·5 to 17·4)

Other drug use disorders 45·3 (42·9 to 48·2) 35·2% (22·8 to 46·1) * * Percentage changes that are statistically significant. 0·6 (0·5 to 0·6) 11·3% (1·2 to 19·9) * * Percentage changes that are statistically significant. 1687·6 (1589·4 to 1805·9) 25·9% (14·0 to 37·3) * * Percentage changes that are statistically significant. 21·0 (19·8 to 22·5) 8·2% (−2·0 to 17·8)

Diabetes and kidney diseases 2611·2 (2557·8 to 2667·2) 34·2% (32·0 to 36·2) * * Percentage changes that are statistically significant. 33·6 (32·9 to 34·3) 1·3% (−0·3 to 2·7) 58 116·9 (56 801·5 to 59 525·7) 25·1% (23·0 to 27·2) * * Percentage changes that are statistically significant. 726·4 (710·0 to 744·4) −1·1% (−2·8 to 0·6)

Diabetes mellitus 1369·8 (1340·3 to 1401·9) 34·7% (32·2 to 37·3) * * Percentage changes that are statistically significant. 17·5 (17·1 to 17·9) 1·2% (−0·7 to 3·1) 29 300·2 (28 711·5 to 29 950·1) 29·9% (27·2 to 32·4) * * Percentage changes that are statistically significant. 363·1 (355·7 to 371·2) 0·7% (−1·4 to 2·6)

Type 1 diabetes mellitus 345·5 (319·3 to 371·1) 15·1% (10·5 to 19·0) * * Percentage changes that are statistically significant. 4·3 (4·0 to 4·7) −11·0% (−14·6 to −7·8) * * Percentage changes that are statistically significant. 9477·3 (8944·6 to 10 079·9) 11·1% (7·2 to 14·3) * * Percentage changes that are statistically significant. 117·3 (110·8 to 124·6) −10·6% (−13·9 to −7·9) * * Percentage changes that are statistically significant.

Type 2 diabetes mellitus 1024·3 (985·5 to 1066·8) 43·0% (40·4 to 45·8) * * Percentage changes that are statistically significant. 13·2 (12·7 to 13·7) 5·9% (4·1 to 8·0) * * Percentage changes that are statistically significant. 19 822·9 (19 013·8 to 20 687·8) 41·3% (38·3 to 44·4) * * Percentage changes that are statistically significant. 245·8 (235·8 to 256·5) 7·1% (5·0 to 9·4) * * Percentage changes that are statistically significant.

Chronic kidney disease 1230·2 (1195·1 to 1258·8) 33·7% (30·5 to 36·1) * * Percentage changes that are statistically significant. 15·9 (15·5 to 16·3) 1·5% (−0·9 to 3·2) 28 508·5 (27 610·2 to 29 314·0) 21·0% (18·2 to 23·5) * * Percentage changes that are statistically significant. 359·4 (348·2 to 369·6) −2·5% (−4·7 to −0·6) * * Percentage changes that are statistically significant.

Chronic kidney disease due to type 1 diabetes mellitus 77·3 (62·4 to 95·2) 23·2% (19·0 to 27·4) * * Percentage changes that are statistically significant. 0·9 (0·8 to 1·2) −1·2% (−4·0 to 1·2) 2622·0 (2121·7 to 3205·5) 17·8% (13·6 to 22·3) * * Percentage changes that are statistically significant. 31·9 (25·9 to 38·9) −2·9% (−5·6 to −0·3) * * Percentage changes that are statistically significant.

Chronic kidney disease due to type 2 diabetes mellitus 349·0 (306·8 to 395·9) 40·5% (36·4 to 43·6) * * Percentage changes that are statistically significant. 4·5 (4·0 to 5·1) 4·2% (1·4 to 6·2) * * Percentage changes that are statistically significant. 6671·9 (5825·5 to 7625·9) 35·4% (31·0 to 38·7) * * Percentage changes that are statistically significant. 82·8 (72·4 to 94·5) 2·9% (−0·2 to 5·2)

Chronic kidney disease due to hypertension 347·4 (304·6 to 391·5) 41·4% (37·4 to 44·2) * * Percentage changes that are statistically significant. 4·6 (4·0 to 5·2) 3·2% (0·4 to 5·2) * * Percentage changes that are statistically significant. 5954·8 (5175·1 to 6741·9) 33·4% (29·3 to 36·5) * * Percentage changes that are statistically significant. 75·2 (65·4 to 84·9) 2·3% (−0·7 to 4·5)

Chronic kidney disease due to glomerulonephritis 189·7 (165·2 to 217·3) 25·5% (22·1 to 28·8) * * Percentage changes that are statistically significant. 2·4 (2·1 to 2·8) −1·3% (−3·2 to 0·7) 5554·9 (4929·1 to 6250·8) 12·7% (9·6 to 16·1) * * Percentage changes that are statistically significant. 70·6 (62·8 to 79·4) −5·5% (−7·5 to −3·3) * * Percentage changes that are statistically significant.

Chronic kidney disease due to other and unspecified causes 266·8 (232·8 to 304·0) 25·9% (22·4 to 29·4) * * Percentage changes that are statistically significant. 3·4 (3·0 to 3·9) −1·4% (−3·7 to 0·6) 7704·8 (6794·9 to 8614·8) 10·0% (6·8 to 13·4) * * Percentage changes that are statistically significant. 98·9 (87·4 to 110·0) −7·7% (−9·9 to −5·4) * * Percentage changes that are statistically significant.

Acute glomerulonephritis 11·2 (10·5 to 12·1) 14·7% (8·7 to 22·3) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·2) −9·5% (−14·5 to −3·5) * * Percentage changes that are statistically significant. 308·2 (282·4 to 336·8) −5·5% (−10·4 to 2·2) 3·9 (3·6 to 4·3) −20·9% (−25·1 to −15·1) * * Percentage changes that are statistically significant.

Skin and subcutaneous diseases 100·3 (65·3 to 131·7) 42·3% (34·9 to 52·0) * * Percentage changes that are statistically significant. 1·3 (0·9 to 1·7) 8·1% (2·7 to 16·5) * * Percentage changes that are statistically significant. 2517·9 (1703·3 to 3283·8) 26·1% (18·6 to 35·7) * * Percentage changes that are statistically significant. 33·1 (22·4 to 43·2) 5·0% (−1·2 to 13·8)

Bacterial skin diseases 76·0 (48·7 to 95·6) 45·5% (36·8 to 54·9) * * Percentage changes that are statistically significant. 1·0 (0·6 to 1·3) 12·7% (6·0 to 20·7) * * Percentage changes that are statistically significant. 2096·6 (1378·0 to 2691·9) 26·4% (18·0 to 36·9) * * Percentage changes that are statistically significant. 27·6 (18·2 to 35·6) 6·4% (−0·6 to 15·9)

Cellulitis 18·9 (10·3 to 26·0) 57·0% (45·8 to 67·1) * * Percentage changes that are statistically significant. 0·2 (0·1 to 0·3) 19·6% (9·8 to 28·2) * * Percentage changes that are statistically significant. 480·1 (264·6 to 640·2) 38·3% (30·8 to 50·4) * * Percentage changes that are statistically significant. 6·2 (3·4 to 8·3) 13·7% (7·3 to 23·9) * * Percentage changes that are statistically significant.

Pyoderma 57·1 (35·8 to 70·8) 42·1% (32·4 to 52·4) * * Percentage changes that are statistically significant. 0·8 (0·5 to 0·9) 10·5% (3·2 to 19·0) * * Percentage changes that are statistically significant. 1616·4 (1051·6 to 2136·7) 23·3% (14·3 to 35·0) * * Percentage changes that are statistically significant. 21·5 (14·1 to 28·8) 4·5% (−3·2 to 15·0)

Decubitus ulcer 20·3 (13·2 to 30·6) 32·4% (22·9 to 51·0) * * Percentage changes that are statistically significant. 0·3 (0·2 to 0·4) −5·1% (−12·2 to 9·2) 321·7 (211·2 to 471·5) 26·2% (17·9 to 42·5) * * Percentage changes that are statistically significant. 4·2 (2·7 to 6·1) −2·3% (−8·8 to 11·5)

Other skin and subcutaneous diseases 3·9 (2·6 to 7·2) 35·8% (26·6 to 49·6) * * Percentage changes that are statistically significant. 0·1 (0·0 to 0·1) 3·3% (−3·5 to 14·4) 99·6 (69·4 to 165·8) 19·1% (10·8 to 34·1) * * Percentage changes that are statistically significant. 1·3 (0·9 to 2·2) 0·7% (−6·1 to 13·1)

Musculoskeletal disorders 121·3 (105·6 to 126·2) 30·9% (25·1 to 35·1) * * Percentage changes that are statistically significant. 1·6 (1·4 to 1·6) −0·1% (−4·4 to 3·2) 2842·7 (2440·7 to 2953·1) 19·6% (13·7 to 23·2) * * Percentage changes that are statistically significant. 35·9 (30·8 to 37·3) −2·5% (−7·1 to 0·4)

Rheumatoid arthritis 47·3 (39·0 to 51·2) 25·8% (16·2 to 31·9) * * Percentage changes that are statistically significant. 0·6 (0·5 to 0·7) −5·9% (−12·9 to −1·2) * * Percentage changes that are statistically significant. 866·0 (707·8 to 941·4) 17·9% (8·6 to 23·3) * * Percentage changes that are statistically significant. 10·9 (8·9 to 11·8) −9·1% (−16·1 to −5·0) * * Percentage changes that are statistically significant.

Other musculoskeletal disorders 74·0 (66·1 to 78·7) 34·4% (30·2 to 38·8) * * Percentage changes that are statistically significant. 1·0 (0·9 to 1·0) 3·9% (0·9 to 7·5) * * Percentage changes that are statistically significant. 1976·6 (1730·3 to 2089·1) 20·3% (15·6 to 24·0) * * Percentage changes that are statistically significant. 25·0 (21·9 to 26·4) 0·8% (−3·0 to 3·8)

Other non-communicable diseases 1153·3 (1101·8 to 1208·3) 0·8% (−3·9 to 4·0) 16·3 (15·5 to 17·1) −11·2% (−15·3 to −8·5) * * Percentage changes that are statistically significant. 68 240·8 (64 835·4 to 72 452·1) −10·6% (−15·8 to −6·9) * * Percentage changes that are statistically significant. 993·0 (941·3 to 1054·3) −16·4% (−21·3 to −12·8) * * Percentage changes that are statistically significant.

Congenital anomalies 584·9 (556·3 to 618·3) −14·3% (−21·1 to −10·1) * * Percentage changes that are statistically significant. 8·7 (8·2 to 9·2) −18·2% (−24·7 to −14·1) * * Percentage changes that are statistically significant. 48 860·4 (46 405·7 to 51 687·3) −15·3% (−22·0 to −11·0) * * Percentage changes that are statistically significant. 729·4 (692·5 to 771·7) −18·8% (−25·2 to −14·6) * * Percentage changes that are statistically significant.

Neural tube defects 61·7 (46·7 to 83·7) −13·1% (−24·5 to −1·0) * * Percentage changes that are statistically significant. 0·9 (0·7 to 1·3) −16·5% (−27·6 to −4·8) * * Percentage changes that are statistically significant. 5317·5 (4017·1 to 7217·5) −13·4% (−24·8 to −1·4) * * Percentage changes that are statistically significant. 80·0 (60·4 to 108·6) −16·7% (−27·7 to −5·0) * * Percentage changes that are statistically significant.

Congenital heart anomalies 261·2 (216·6 to 308·2) −17·9% (−24·6 to −9·8) * * Percentage changes that are statistically significant. 3·9 (3·2 to 4·6) −21·8% (−28·1 to −14·1) * * Percentage changes that are statistically significant. 21 634·4 (17 770·6 to 25 604·8) −18·9% (−25·5 to −10·8) * * Percentage changes that are statistically significant. 321·7 (263·6 to 381·4) −22·4% (−28·7 to −14·6) * * Percentage changes that are statistically significant.

Orofacial clefts 3·8 (1·5 to 8·8) −40·0% (−54·5 to −22·5) * * Percentage changes that are statistically significant. 0·1 (0·0 to 0·1) −41·9% (−55·9 to −25·1) * * Percentage changes that are statistically significant. 331·3 (130·1 to 770·5) −40·0% (−54·5 to −22·7) * * Percentage changes that are statistically significant. 5·0 (2·0 to 11·7) −41·9% (−56·0 to −25·2) * * Percentage changes that are statistically significant.

Down syndrome 26·1 (21·3 to 35·1) 3·1% (−7·4 to 17·4) 0·4 (0·3 to 0·5) −5·2% (−14·2 to 7·0) 1906·1 (1481·7 to 2707·9) −1·4% (−11·5 to 13·9) 27·7 (21·3 to 39·8) −7·3% (−16·7 to 7·1)

Other chromosomal abnormalities 17·9 (12·0 to 26·3) 4·6% (−6·3 to 18·2) 0·3 (0·2 to 0·4) 0·3% (−10·1 to 13·2) 1507·9 (1012·2 to 2233·3) 3·9% (−6·9 to 17·4) 22·6 (15·1 to 33·5) 0·0% (−10·4 to 13·0)

Congenital musculoskeletal and limb anomalies 11·0 (8·6 to 14·0) −8·7% (−17·3 to 0·0) 0·2 (0·1 to 0·2) −12·8% (−20·9 to −4·5) * * Percentage changes that are statistically significant. 912·2 (708·9 to 1172·9) −9·8% (−18·2 to −1·0) * * Percentage changes that are statistically significant. 13·6 (10·6 to 17·5) −13·3% (−21·5 to −4·9) * * Percentage changes that are statistically significant.

Urogenital congenital anomalies 14·1 (10·3 to 16·9) −2·5% (−11·8 to 9·2) 0·2 (0·1 to 0·2) −8·5% (−17·1 to 2·1) 1105·8 (781·3 to 1347·8) −5·5% (−14·6 to 6·3) 16·4 (11·5 to 20·0) −9·7% (−18·3 to 1·3)

Digestive congenital anomalies 50·8 (37·7 to 71·8) −16·2% (−27·1 to −6·4) * * Percentage changes that are statistically significant. 0·8 (0·6 to 1·1) −19·3% (−29·8 to −9·8) * * Percentage changes that are statistically significant. 4398·7 (3253·9 to 6229·0) −16·5% (−27·3 to −6·7) * * Percentage changes that are statistically significant. 66·3 (49·0 to 93·9) −19·4% (−29·9 to −9·9) * * Percentage changes that are statistically significant.

Other congenital anomalies 138·3 (102·3 to 175·6) −12·4% (−20·1 to −0·5) * * Percentage changes that are statistically significant. 2·1 (1·5 to 2·6) −15·9% (−23·3 to −4·5) * * Percentage changes that are statistically significant. 11 746·6 (8613·3 to 14 951·0) −13·0% (−20·7 to −1·1) * * Percentage changes that are statistically significant. 176·1 (128·8 to 224·2) −16·3% (−23·7 to −4·8) * * Percentage changes that are statistically significant.

Urinary diseases and male infertility 271·2 (263·9 to 282·2) 39·6% (34·9 to 43·4) * * Percentage changes that are statistically significant. 3·6 (3·5 to 3·7) 5·7% (2·2 to 8·5) * * Percentage changes that are statistically significant. 6255·2 (6044·8 to 6542·1) 20·8% (15·5 to 24·9) * * Percentage changes that are statistically significant. 81·1 (78·3 to 84·8) −0·7% (−5·1 to 2·7)

Urinary tract infections 206·4 (197·9 to 223·2) 48·3% (42·9 to 53·5) * * Percentage changes that are statistically significant. 2·7 (2·6 to 3·0) 10·9% (7·2 to 14·5) * * Percentage changes that are statistically significant. 4522·3 (4285·2 to 5016·3) 31·4% (24·4 to 38·8) * * Percentage changes that are statistically significant. 58·4 (55·2 to 65·0) 7·2% (1·7 to 13·0) * * Percentage changes that are statistically significant.

Urolithiasis 12·3 (10·5 to 15·7) 30·4% (19·0 to 49·4) * * Percentage changes that are statistically significant. 0·2 (0·1 to 0·2) −1·2% (−9·7 to 12·9) 255·1 (216·0 to 323·5) 19·6% (9·7 to 36·9) * * Percentage changes that are statistically significant. 3·2 (2·7 to 4·0) −5·9% (−13·6 to 7·7)

Other urinary diseases 52·5 (42·3 to 58·0) 15·0% (8·0 to 25·5) * * Percentage changes that are statistically significant. 0·7 (0·6 to 0·8) −9·9% (−15·3 to −2·2) * * Percentage changes that are statistically significant. 1477·8 (1172·2 to 1660·2) −3·0% (−9·6 to 6·4) 19·4 (15·4 to 21·9) −18·2% (−23·3 to −10·6) * * Percentage changes that are statistically significant.

Gynaecological diseases 8·2 (7·4 to 8·7) 19·1% (5·1 to 30·0) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·1) −2·6% (−13·6 to 6·0) 292·9 (272·6 to 318·7) 9·2% (−2·8 to 20·6) 3·7 (3·4 to 4·0) −6·0% (−15·4 to 3·6)

Uterine fibroids 2·4 (1·6 to 3·0) 33·3% (6·7 to 54·6) * * Percentage changes that are statistically significant. 0·0 (0·0 to 0·0) 8·1% (−14·9 to 24·7) 74·2 (52·7 to 95·5) 13·0% (−4·2 to 31·6) 0·9 (0·6 to 1·2) −4·8% (−20·0 to 10·5)

Polycystic ovarian syndrome 0·0 (0·0 to 0·0) 12·9% (−12·8 to 50·4) 0·0 (0·0 to 0·0) 1·0% (−22·5 to 34·8) 0·7 (0·1 to 1·5) 10·1% (−15·8 to 51·2) 0·0 (0·0 to 0·0) −0·1% (−24·3 to 37·2)

Endometriosis 0·2 (0·1 to 0·2) 11·8% (−12·4 to 45·5) 0·0 (0·0 to 0·0) −3·2% (−23·8 to 25·5) 7·7 (3·2 to 12·0) 10·4% (−12·9 to 41·7) 0·1 (0·0 to 0·1) −3·2% (−23·2 to 24·3)

Genital prolapse 0·6 (0·3 to 0·9) 0·6% (−15·4 to 16·1) 0·0 (0·0 to 0·0) −24·1% (−36·0 to −13·0) * * Percentage changes that are statistically significant. 14·5 (6·8 to 20·1) −4·4% (−18·4 to 10·4) 0·2 (0·1 to 0·2) −24·0% (−35·2 to −11·9) * * Percentage changes that are statistically significant.

Other gynaecological diseases 5·0 (4·1 to 5·6) 16·0% (4·1 to 27·9) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·1) −3·6% (−12·2 to 5·9) 195·8 (163·0 to 228·9) 8·9% (−2·9 to 20·6) 2·5 (2·1 to 2·9) −4·8% (−14·2 to 5·1)

Haemoglobinopathies and haemolytic anaemias 104·6 (82·0 to 132·2) 5·8% (−1·4 to 13·4) 1·4 (1·1 to 1·8) −11·3% (−17·6 to −4·8) * * Percentage changes that are statistically significant. 4831·6 (3643·1 to 6268·9) −1·8% (−13·1 to 9·4) 66·6 (50·0 to 86·2) −11·1% (−21·6 to −0·5) * * Percentage changes that are statistically significant.

Thalassaemias 7·2 (6·0 to 8·4) −23·7% (−32·6 to −12·7) * * Percentage changes that are statistically significant. 0·1 (0·1 to 0·1) −27·9% (−36·5 to −17·2) * * Percentage changes that are statistically significant. 564·7 (474·8 to 667·6) −24·6% (−33·9 to −13·2) * * Percentage changes that are statistically significant. 8·2 (6·9 to 9·7) −28·6% (−37·6 to −17·6) * * Percentage changes that are statistically significant.

Sickle cell disorders 38·4 (24·0 to 54·8) 3·7% (−11·6 to 17·7) 0·5 (0·3 to 0·8) −3·1% (−17·6 to 10·3) 2796·4 (1747·3 to 3913·6) 2·1% (−13·7 to 17·3) 39·7 (24·8 to 55·3) −3·9% (−19·1 to 11·0)

G6PD deficiency 16·7 (12·1 to 22·5) 11·8% (4·7 to 19·6) * * Percentage changes that are statistically significant. 0·2 (0·2 to 0·3) −7·1% (−12·1 to −1·0) * * Percentage changes that are statistically significant. 692·6 (522·0 to 896·1) 4·4% (−2·5 to 12·3) 8·8 (6·7 to 11·4) −9·6% (−15·0 to −3·3) * * Percentage changes that are statistically significant.

Other haemoglobinopathies and haemolytic anaemias 42·2 (35·1 to 49·2) 13·0% (9·3 to 16·5) * * Percentage changes that are statistically significant. 0·6 (0·5 to 0·6) −16·1% (−18·7 to −13·4) * * Percentage changes that are statistically significant. 777·8 (634·5 to 917·2) 1·3% (−2·2 to 4·8) 9·9 (8·1 to 11·7) −19·9% (−22·3 to −17·4) * * Percentage changes that are statistically significant.

Endocrine, metabolic, blood, and immune disorders 144·5 (115·1 to 152·3) 28·2% (19·7 to 33·3) * * Percentage changes that are statistically significant. 1·9 (1·5 to 2·0) 0·8% (−5·0 to 4·4) 4506·4 (3762·3 to 4919·9) 10·4% (2·7 to 16·9) * * Percentage changes that are statistically significant. 59·7 (50·0 to 65·5) −5·5% (−11·2 to −0·2) * * Percentage changes that are statistically significant.

Sudden infant death syndrome 40·0 (18·0 to 77·0) −17·3% (−28·6 to −1·4) * * Percentage changes that are statistically significant. 0·6 (0·3 to 1·2) −20·2% (−31·2 to −4·9) * * Percentage changes that are statistically significant. 3494·3 (1570·1 to 6734·0) −17·3% (−28·6 to −1·4) * * Percentage changes that are statistically significant. 52·7 (23·7 to 101·5) −20·2% (−31·2 to −4·9) * * Percentage changes that are statistically significant.

Injuries 4484·7 (4332·0 to 4585·6) 2·3% (0·5 to 4·0) * * Percentage changes that are statistically significant. 57·9 (55·9 to 59·2) −13·7% (−15·1 to −12·2) * * Percentage changes that are statistically significant. 195 231·1 (188 807·7 to 199 825·5) −6·4% (−7·8 to −4·8) * * Percentage changes that are statistically significant. 2548·3 (2461·9 to 2609·6) −16·9% (−18·2 to −15·3) * * Percentage changes that are statistically significant.

Transport injuries 1335·0 (1289·1 to 1369·5) −3·1% (−6·0 to −0·6) * * Percentage changes that are statistically significant. 17·0 (16·4 to 17·4) −17·0% (−19·5 to −14·9) * * Percentage changes that are statistically significant. 61 937·8 (60 031·2 to 63 736·5) −9·6% (−11·8 to −7·3) * * Percentage changes that are statistically significant. 800·5 (775·9 to 823·3) −19·5% (−21·4 to −17·5) * * Percentage changes that are statistically significant.

Road injuries 1243·1 (1191·9 to 1276·9) −3·2% (−6·3 to −0·5) * * Percentage changes that are statistically significant. 15·8 (15·2 to 16·3) −17·1% (−19·7 to −14·9) * * Percentage changes that are statistically significant. 57 638·4 (55 500·8 to 59 369·2) −9·7% (−12·0 to −7·3) * * Percentage changes that are statistically significant. 745·0 (718·1 to 767·4) −19·6% (−21·6 to −17·5) * * Percentage changes that are statistically significant.

Pedestrian road injuries 486·2 (459·7 to 535·0) −6·4% (−11·7 to −2·1) * * Percentage changes that are statistically significant. 6·2 (5·9 to 6·8) −21·4% (−25·5 to −17·9) * * Percentage changes that are statistically significant. 20 850·8 (19 596·0 to 23 164·4) −14·8% (−18·7 to −11·0) * * Percentage changes that are statistically significant. 270·4 (253·9 to 300·8) −25·1% (−28·3 to −21·9) * * Percentage changes that are statistically significant.

Cyclist road injuries 68·9 (59·2 to 76·2) 9·1% (1·8 to 16·4) * * Percentage changes that are statistically significant. 0·9 (0·7 to 1·0) −8·8% (−14·8 to −2·5) * * Percentage changes that are statistically significant. 2853·5 (2471·6 to 3209·0) 1·0% (−5·7 to 8·3) 36·3 (31·5 to 41·0) −11·8% (−17·8 to −5·3) * * Percentage changes that are statistically significant.

Motorcyclist road injuries 225·7 (196·1 to 238·6) −0·6% (−8·9 to 5·2) 2·9 (2·5 to 3·0) −12·4% (−19·5 to −7·3) * * Percentage changes that are statistically significant. 11 416·3 (9969·6 to 12 098·0) −5·7% (−12·5 to −0·5) * * Percentage changes that are statistically significant. 146·2 (127·5 to 154·9) −14·8% (−20·7 to −10·1) * * Percentage changes that are statistically significant.

Motor vehicle road injuries 451·1 (423·4 to 472·9) −2·5% (−6·2 to 1·3) 5·8 (5·4 to 6·0) −15·6% (−18·6 to −12·2) * * Percentage changes that are statistically significant. 22 004·1 (20 639·8 to 23 130·9) −7·8% (−10·4 to −3·0) * * Percentage changes that are statistically significant. 285·3 (267·6 to 299·7) −17·2% (−19·6 to −12·8) * * Percentage changes that are statistically significant.

Other road injuries 11·2 (9·9 to 12·8) −5·5% (−11·0 to 16·1) 0·1 (0·1 to 0·2) −19·4% (−24·1 to −1·3) * * Percentage changes that are statistically significant. 513·8 (454·1 to 583·4) −11·7% (−17·3 to 10·6) 6·7 (5·9 to 7·6) −21·4% (−26·5 to −1·7) * * Percentage changes that are statistically significant.

Other transport injuries 91·9 (84·5 to 107·2) −1·5% (−6·2 to 3·7) 1·2 (1·1 to 1·4) −15·5% (−19·5 to −10·9) * * Percentage changes that are statistically significant. 4299·4 (3919·6 to 5048·3) −7·8% (−12·6 to −2·4) * * Percentage changes that are statistically significant. 55·4 (50·5 to 65·0) −17·9% (−22·2 to −13·2) * * Percentage changes that are statistically significant.

Unintentional injuries 1804·9 (1695·7 to 1872·0) 2·9% (0·5 to 6·0) * * Percentage changes that are statistically significant. 23·8 (22·4 to 24·7) −15·3% (−17·3 to −12·8) * * Percentage changes that are statistically significant. 69 430·5 (64 685·1 to 72 366·8) −12·8% (−15·0 to −9·6) * * Percentage changes that are statistically significant. 928·8 (865·6 to 969·3) −23·0% (−25·0 to −20·0) * * Percentage changes that are statistically significant.

Falls 695·8 (644·9 to 741·7) 27·4% (21·2 to 35·6) * * Percentage changes that are statistically significant. 9·2 (8·5 to 9·8) −2·8% (−7·4 to 3·4) 16 688·1 (15 101·9 to 17 636·8) 10·1% (4·8 to 17·2) * * Percentage changes that are statistically significant. 216·6 (196·4 to 228·6) −8·4% (−12·7 to −2·5) * * Percentage changes that are statistically significant.

Drowning 295·2 (284·5 to 306·2) −17·2% (−19·8 to −14·1) * * Percentage changes that are statistically significant. 4·0 (3·8 to 4·1) −27·3% (−29·6 to −24·5) * * Percentage changes that are statistically significant. 16 563·3 (15 784·2 to 17 350·0) −26·1% (−29·0 to −22·4) * * Percentage changes that are statistically significant. 228·3 (217·2 to 239·7) −32·8% (−35·5 to −29·3) * * Percentage changes that are statistically significant.

Fire heat and hot substances 120·6 (101·6 to 129·4) −7·9% (−10·9 to −1·2) * * Percentage changes that are statistically significant. 1·6 (1·3 to 1·7) −22·9% (−25·4 to −17·3) * * Percentage changes that are statistically significant. 5286·3 (4308·9 to 5836·4) −16·5% (−21·0 to −7·3) * * Percentage changes that are statistically significant. 71·0 (57·8 to 78·6) −25·5% (−29·6 to −17·1) * * Percentage changes that are statistically significant.

Poisonings 72·4 (52·7 to 79·4) −6·8% (−16·1 to 2·9) 0·9 (0·7 to 1·0) −20·8% (−28·4 to −12·5) * * Percentage changes that are statistically significant. 3321·7 (2454·1 to 3669·2) −14·6% (−22·7 to −3·8) * * Percentage changes that are statistically significant. 44·1 (32·7 to 48·8) −23·9% (−31·0 to −14·1) * * Percentage changes that are statistically significant.

Poisoning by carbon monoxide 35·5 (25·7 to 38·8) −12·5% (−22·4 to −5·0) * * Percentage changes that are statistically significant. 0·5 (0·3 to 0·5) −26·6% (−34·8 to −20·3) * * Percentage changes that are statistically significant. 1462·4 (1073·0 to 1613·6) −19·1% (−27·2 to −11·8) * * Percentage changes that are statistically significant. 18·9 (13·8 to 20·9) −29·0% (−36·2 to −22·4) * * Percentage changes that are statistically significant.

Poisoning by other means 36·9 (26·8 to 41·0) −0·5% (−10·1 to 11·9) 0·5 (0·4 to 0·5) −14·4% (−22·4 to −3·9) * * Percentage changes that are statistically significant. 1859·3 (1385·8 to 2072·9) −10·7% (−19·6 to 3·3) 25·2 (19·0 to 28·1) −19·6% (−27·7 to −6·8) * * Percentage changes that are statistically significant.

Exposure to mechanical forces 136·5 (117·6 to 143·2) −6·7% (−9·8 to −3·7) * * Percentage changes that are statistically significant. 1·8 (1·5 to 1·8) −20·3% (−22·9 to −17·8) * * Percentage changes that are statistically significant. 6385·5 (5500·4 to 6710·8) −13·8% (−16·6 to −10·8) * * Percentage changes that are statistically significant. 84·0 (72·3 to 88·3) −23·0% (−25·5 to −20·3) * * Percentage changes that are statistically significant.

Unintentional firearm injuries 22·6 (21·1 to 25·8) −2·9% (−7·5 to 2·8) 0·3 (0·3 to 0·3) −16·4% (−20·3 to −11·5) * * Percentage changes that are statistically significant. 1094·5 (1013·5 to 1275·4) −7·4% (−12·2 to −1·3) * * Percentage changes that are statistically significant. 14·4 (13·3 to 16·9) −16·5% (−20·9 to −11·1) * * Percentage changes that are statistically significant.

Other exposure to mechanical forces 113·9 (94·7 to 120·8) −7·4% (−10·6 to −4·1) * * Percentage changes that are statistically significant. 1·5 (1·2 to 1·6) −21·0% (−23·7 to −18·3) * * Percentage changes that are statistically significant. 5291·0 (4401·1 to 5626·1) −15·0% (−18·0 to −11·7) * * Percentage changes that are statistically significant. 69·6 (57·8 to 74·0) −24·3% (−26·9 to −21·2) * * Percentage changes that are statistically significant.

Adverse effects of medical treatment 121·6 (103·6 to 137·6) 16·6% (12·0 to 20·9) * * Percentage changes that are statistically significant. 1·6 (1·4 to 1·8) −6·2% (−10·0 to −2·5) * * Percentage changes that are statistically significant. 4363·9 (3619·9 to 5234·0) 4·0% (−1·2 to 11·0) 58·1 (48·0 to 70·7) −9·5% (−