NEW YORK (Reuters) - World stocks declined in their biggest two-day dive in 16 months on Tuesday as tumbling oil prices and a jump in global borrowing costs cooled the year’s euphoric start in financial markets.

Traders work on the floor of the New York Stock Exchange (NYSE) in New York, U.S., January 26, 2018. REUTERS/Brendan McDermid

Lackluster German inflation curbed a rise in U.S. Treasury yields - the benchmark for world lending rates - after they touched their strongest level in nearly four years overnight at 2.733 percent.

Stocks on Wall Street shed about 1 percent, led by a plunge in healthcare-related companies after Amazon.com, Berkshire Hathaway and JPMorgan said they plan to form a venture to cut healthcare costs for their U.S. employees.

Healthcare tumbled 2.13 percent, the biggest decline among the 11 major S&P 500 sectors.

Health insurer UnitedHealth and drugmaker Pfizer were among the top five decliners in the S&P 500, falling 4.35 percent and 3.13 percent, respectively.

Pfizer had gained about 2 percent in pre-market trading after the company’s quarterly results and full-year forecasts beat expectations.

Stocks were also pulled lower by a decline in energy shares amid ongoing evidence of rising U.S. crude output.

The S&P energy sector fell 2.0 percent.

Investors were spooked by the first two-day decline on Wall Street so far this year, which prompted a flight to the safety of U.S. government bonds, said Gennadiy Goldberg, interest rates strategist at TD Securities in New York.

Investors awaited President Donald Trump’s first State of the Union address to Congress Tuesday night, a Federal Reserve statement on Wednesday and a jobs report on Friday that serves as a key barometer of the U.S. economy.

The Fed will be watched for comments that could quicken the pace of expected interest rate hikes this year as the inflation outlook has firmed in recent readings.

“Investors are getting a bit worried about inflation, which has led some people to believe that the Fed might be more aggressive when it comes to raising rates,” said Robert Pavlik, chief investment strategist at SlateStone Wealth.

“Despite this selloff, all indications point to a firming economy and I do expect to see some bargain hunters step in soon,” Pavlik said.

It was largest two-day decline for both the Dow and MSCI’s gauge of worldwide stock performance since September 2016. The S&P 500 is still up 5.5 percent in January.

On Wall Street, the Dow Jones Industrial Average fell 362.59 points, or 1.37 percent, to 26,076.89. The S&P 500 lost 31.1 points, or 1.09 percent, to 2,822.43 and the Nasdaq Composite dropped 64.02 points, or 0.86 percent, to 7,402.48.

The pan-European FTSEurofirst 300 index closed down 0.83 percent and MSCI’s all-country world stock index shed 0.99 percent. MSCI’s emerging markets index fell 1.6 percent.

Benchmark 10-year U.S. Treasury notes fell 5/32 in price to yield 2.7199 percent.

Germany’s 10-year bond fell to 0.68 percent, down about 1 basis point on the day. After going positive for the first time since late 2015 on Monday, five-year German bond yields slipped back into negative territory.

The dollar reversed Monday’s gains. After six straight weekly declines, the dollar index was on track to fall about 3.4 percent for the month, which would be its biggest monthly fall since March 2016.

The dollar index fell 0.12 percent, with the euro up 0.14 percent to $1.2398. The Japanese yen strengthened 0.17 percent versus the greenback at 108.80 per dollar.

Brent crude futures settled down 44 cents to $69.02 a barrel, while West Texas Intermediate futures slid $1.06 to settle at $64.50.

Expectations for U.S. crude inventories to rise for the first time in 11 weeks may also be keeping oil under pressure, according to a preliminary poll by Reuters on Monday.

“The global trend seems to be indicating more oil is coming into the market despite best efforts by the Saudis and Russians to curtail output,” said John Kilduff, partner at Again Capital LLC in New York.

Gold slipped back to a one-week low.

U.S. gold futures for February delivery settled down $4.90 at $1,335.40 per ounce.