WASHINGTON — The United States and Britain, Saudi Arabia’s biggest arms suppliers, are stepping up their pressure for a cease-fire in the Yemen war, the world’s worst man-made humanitarian disaster.

The calls for a halt to the conflict — by Secretary of State Mike Pompeo on Tuesday night, his British counterpart, Jeremy Hunt, on Wednesday, and Defense Secretary Jim Mattis starting last weekend — came as criticism of Saudi Arabia has surged over its bombing campaign in Yemen and the killing of Jamal Khashoggi, a dissident Saudi writer.

The Saudi-led bombings have been a major cause of civilian deaths and destruction during the three-and-a-half-year-old conflict in Yemen, the Arab world’s poorest country.

“It is time to end this conflict, replace conflict with compromise, and allow the Yemeni people to heal through peace and reconstruction,” Mr. Pompeo said in a statement posted on the State Department website Tuesday night.