Michael Graves, one of the most prominent and prolific American architects of the latter 20th century, who designed more than 350 buildings around the world but was perhaps best known for his teakettle and pepper mill, died on Thursday at his home in Princeton, N.J. He was 80.

His death was confirmed by his firm, Michael Graves & Associates, which did not specify a cause. He had been paralyzed from the waist down since 2003 as a result of a spinal cord infection.

Mr. Graves was first associated with the New York Five, a group of architects who achieved cult-like stature by helping to redefine modernism in the 1970s. He went on to design projects like the headquarters of the health care company Humana in Louisville, Ky., and the Portland Building in Oregon, which exemplified postmodernism with their reliance on color and ornament and made him a celebrity.

He used his fame as a brand, designing housewares for Target while continuing to run a busy practice even as postmodernism fell out of fashion and Mr. Graves’s reputation with it.