Abu-Elheiga L.

Wu H.

Gu Z.

Bressler R.

Wakil S.J. Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. J. Biol. Chem. 287 : 12578-12588 View in Article Scopus (57)

PubMed

Crossref

Google Scholar

Abulizi A.

Perry R.J.

Camporez J.P.G.

Jurczak M.J.

Petersen K.F.

Aspichueta P.

Shulman G.I. A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice. FASEB J. 31 : 2916-2924 View in Article Scopus (18)

PubMed

Crossref

Google Scholar

Agarwal S.

Patil A.

Aware U.

Deshmukh P.

Darji B.

Sasane S.

Sairam K.V.

Priyadarsiny P.

Giri P.

Patel H.

et al. Discovery of a potent and orally efficacious TGR5 receptor agonist. ACS Med. Chem. Lett. 7 : 51-55 View in Article Scopus (7)

PubMed

Crossref

Google Scholar

Armstrong M.J.

Barton D.

Gaunt P.

Hull D.

Guo K.

Stocken D.

Gough S.C.

Tomlinson J.W.

Brown R.M.

Hübscher S.G.

Newsome P.N.

LEAN trial team Liraglutide efficacy and action in non-alcoholic steatohepatitis (LEAN): study protocol for a phase II multicentre, double-blinded, randomised, controlled trial. BMJ Open. 3 : e003995 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Baldry E.L.

Aithal G.P.

Kaye P.

Idris I.R.

Bennett A.

Leeder P.C.

Macdonald I.A. Effects of short-term energy restriction on liver lipid content and inflammatory status in severely obese adults: Results of a randomized controlled trial using 2 dietary approaches. Diabetes Obes. Metab. 19 : 1179-1183 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Basantani M.K.

Sitnick M.T.

Cai L.

Brenner D.S.

Gardner N.P.

Li J.Z.

Schoiswohl G.

Yang K.

Kumari M.

Gross R.W.

et al. Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome. J. Lipid Res. 52 : 318-329 View in Article Scopus (139)

PubMed

Crossref

Google Scholar

Belfort R.

Harrison S.A.

Brown K.

Darland C.

Finch J.

Hardies J.

Balas B.

Gastaldelli A.

Tio F.

Pulcini J.

et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N. Engl. J. Med. 355 : 2297-2307 View in Article Scopus (1184)

PubMed

Crossref

Google Scholar

Bergman R.N. New concepts in extracellular signaling for insulin action: the single gateway hypothesis. Recent Prog. Horm. Res. 52 ( ) : 359-385 View in Article PubMed

Google Scholar

Billeter A.T.

Senft J.

Gotthardt D.

Knefeli P.

Nickel F.

Schulte T.

Fischer L.

Nawroth P.P.

Büchler M.W.

Müller-Stich B.P. Combined non-alcoholic fatty liver disease and type 2 diabetes mellitus: sleeve gastrectomy or gastric bypass?—a controlled matched pair study of 34 patients. Obes. Surg. 26 : 1867-1874 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Bindesbøll C.

Fan Q.

Nørgaard R.C.

MacPherson L.

Ruan H.-B.

Wu J.

Pedersen T.Å.

Steffensen K.R.

Yang X.

Matthews J.

et al. Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. J. Lipid Res. 56 : 771-785 View in Article Scopus (6)

PubMed

Crossref

Google Scholar

Boursier J.

Mueller O.

Barret M.

Machado M.

Fizanne L.

Araujo-Perez F.

Guy C.D.

Seed P.C.

Rawls J.F.

David L.A.

et al. The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology. 63 : 764-775 View in Article Scopus (318)

PubMed

Crossref

Google Scholar

Bray G.A.

Popkin B.M. Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar. Diabetes Care. 37 : 950-956 View in Article Scopus (185)

PubMed

Crossref

Google Scholar

Bricker D.K.

Taylor E.B.

Schell J.C.

Orsak T.

Boutron A.

Chen Y.C.

Cox J.E.

Cardon C.M.

Van Vranken J.G.

Dephoure N.

et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science. 337 : 96-100 View in Article Scopus (351)

PubMed

Crossref

Google Scholar

Briere D.A.

Ruan X.

Cheng C.C.

Siesky A.M.

Fitch T.E.

Dominguez C.

Sanfeliciano S.G.

Montero C.

Suen C.S.

Xu Y.

et al. Novel small molecule agonist of TGR5 possesses anti-diabetic effects but causes gallbladder filling in mice. PLoS ONE. 10 : e0136873 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Browning J.D.

Szczepaniak L.S.

Dobbins R.

Nuremberg P.

Horton J.D.

Cohen J.C.

Grundy S.M.

Hobbs H.H. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 40 : 1387-1395 View in Article Scopus (2521)

PubMed

Crossref

Google Scholar

Buch S.

Stickel F.

Trépo E.

Way M.

Herrmann A.

Nischalke H.D.

Brosch M.

Rosendahl J.

Berg T.

Ridinger M.

et al. A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis. Nat. Genet. 47 : 1443-1448 View in Article Scopus (171)

PubMed

Crossref

Google Scholar

Cai K.

Sewer M.B. Diacylglycerol kinase θ couples farnesoid X receptor-dependent bile acid signalling to Akt activation and glucose homoeostasis in hepatocytes. Biochem. J. 454 : 267-274 View in Article Scopus (15)

PubMed

Crossref

Google Scholar

Camporez J.P.

Jornayvaz F.R.

Petersen M.C.

Pesta D.

Guigni B.A.

Serr J.

Zhang D.

Kahn M.

Samuel V.T.

Jurczak M.J.

Shulman G.I. Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology. 154 : 3099-3109 View in Article Scopus (113)

PubMed

Crossref

Google Scholar

Cao J.

Zhou Y.

Peng H.

Huang X.

Stahler S.

Suri V.

Qadri A.

Gareski T.

Jones J.

Hahm S.

et al. Targeting Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases. J. Biol. Chem. 286 : 41838-41851 View in Article Scopus (92)

PubMed

Crossref

Google Scholar

Carino A.

Cipriani S.

Marchianò S.

Biagioli M.

Santorelli C.

Donini A.

Zampella A.

Monti M.C.

Fiorucci S. BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis. Sci. Rep. 7 : 42801 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Cariou B.

Hanf R.

Lambert-Porcheron S.

Zaïr Y.

Sauvinet V.

Noël B.

Flet L.

Vidal H.

Staels B.

Laville M. Dual peroxisome proliferator-activated receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. Diabetes Care. 36 : 2923-2930 View in Article Scopus (92)

PubMed

Crossref

Google Scholar

Chen Z.

Vigueira P.A.

Chambers K.T.

Hall A.M.

Mitra M.S.

Qi N.

McDonald W.G.

Colca J.R.

Kletzien R.F.

Finck B.N. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J. Biol. Chem. 287 : 23537-23548 View in Article Scopus (65)

PubMed

Crossref

Google Scholar

Choi C.S.

Savage D.B.

Kulkarni A.

Yu X.X.

Liu Z.X.

Morino K.

Kim S.

Distefano A.

Samuel V.T.

Neschen S.

et al. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. J. Biol. Chem. 282 : 22678-22688 View in Article Scopus (244)

PubMed

Crossref

Google Scholar

Chow J.D.

Lawrence R.T.

Healy M.E.

Dominy J.E.

Liao J.A.

Breen D.S.

Byrne F.L.

Kenwood B.M.

Lackner C.

Okutsu S.

et al. Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation. Mol. Metab. 3 : 419-431 View in Article Scopus (48)

PubMed

Crossref

Google Scholar

Cline G.W.

Petersen K.F.

Krssak M.

Shen J.

Hundal R.S.

Trajanoski Z.

Inzucchi S.

Dresner A.

Rothman D.L.

Shulman G.I. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N. Engl. J. Med. 341 : 240-246 View in Article Scopus (472)

PubMed

Crossref

Google Scholar

Couillard C.

Bergeron N.

Prud’homme D.

Bergeron J.

Tremblay A.

Bouchard C.

Mauriège P.

Després J.P. Gender difference in postprandial lipemia : importance of visceral adipose tissue accumulation. Arterioscler. Thromb. Vasc. Biol. 19 : 2448-2455 View in Article PubMed

Crossref

Google Scholar

Cusi K.

Orsak B.

Bril F.

Lomonaco R.

Hecht J.

Ortiz-Lopez C.

Tio F.

Hardies J.

Darland C.

Musi N.

et al. Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial. Ann. Intern. Med. 165 : 305-315 View in Article PubMed

Crossref

Google Scholar

Cuthbertson D.J.

Steele T.

Wilding J.P.

Halford J.C.

Harrold J.A.

Hamer M.

Karpe F. What have human experimental overfeeding studies taught us about adipose tissue expansion and susceptibility to obesity and metabolic complications?. Int. J. Obes. 41 : 853-865 View in Article Scopus (44)

PubMed

Crossref

Google Scholar

Després J.P.

Moorjani S.

Lupien P.J.

Tremblay A.

Nadeau A.

Bouchard C. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis. 10 : 497-511 View in Article PubMed

Crossref

Google Scholar

Divakaruni A.S.

Wiley S.E.

Rogers G.W.

Andreyev A.Y.

Petrosyan S.

Loviscach M.

Wall E.A.

Yadava N.

Heuck A.P.

Ferrick D.A.

et al. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc. Natl. Acad. Sci. USA. 110 : 5422-5427 View in Article Scopus (145)

PubMed

Crossref

Google Scholar

Donnelly K.L.

Smith C.I.

Schwarzenberg S.J.

Jessurun J.

Boldt M.D.

Parks E.J. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J. Clin. Invest. 115 : 1343-1351 View in Article PubMed

Crossref

Google Scholar

Dresner A.

Laurent D.

Marcucci M.

Griffin M.E.

Dufour S.

Cline G.W.

Slezak L.A.

Andersen D.K.

Hundal R.S.

Rothman D.L.

et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J. Clin. Invest. 103 : 253-259 View in Article PubMed

Crossref

Google Scholar

Edgerton D.S.

Kraft G.

Smith M.

Farmer B.

Williams P.E.

Coate K.C.

Printz R.L.

O’Brien R.M.

Cherrington A.D. Insulin’s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion. JCI Insight. 2 : e91863 View in Article PubMed

Crossref

Google Scholar

Erion D.M.

Popov V.

Hsiao J.J.

Vatner D.

Mitchell K.

Yonemitsu S.

Nagai Y.

Kahn M.

Gillum M.P.

Dong J.

et al. The role of the carbohydrate response element-binding protein in male fructose-fed rats. Endocrinology. 154 : 36-44 View in Article Scopus (40)

PubMed

Crossref

Google Scholar

Fabbrini E.

Magkos F.

Mohammed B.S.

Pietka T.

Abumrad N.A.

Patterson B.W.

Okunade A.

Klein S. Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc. Natl. Acad. Sci. USA. 106 : 15430-15435 View in Article Scopus (629)

PubMed

Crossref

Google Scholar

Fabbrini E.

Mohammed B.S.

Korenblat K.M.

Magkos F.

McCrea J.

Patterson B.W.

Klein S. Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease. J. Clin. Endocrinol. Metab. 95 : 2727-2735 View in Article Scopus (97)

PubMed

Crossref

Google Scholar

Flannery C.

Dufour S.

Rabøl R.

Shulman G.I.

Petersen K.F. Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly. Diabetes. 61 : 2711-2717 View in Article Scopus (74)

PubMed

Crossref

Google Scholar

Francois M.E.

Baldi J.C.

Manning P.J.

Lucas S.J.

Hawley J.A.

Williams M.J.

Cotter J.D. ‘Exercise snacks’ before meals: a novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia. 57 : 1437-1445 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Futatsugi K.

Kung D.W.

Orr S.T.

Cabral S.

Hepworth D.

Aspnes G.

Bader S.

Bian J.

Boehm M.

Carpino P.A.

et al. Discovery and optimization of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2). J. Med. Chem. 58 : 7173-7185 View in Article Scopus (30)

PubMed

Crossref

Google Scholar

Hall A.M.

Kou K.

Chen Z.

Pietka T.A.

Kumar M.

Korenblat K.M.

Lee K.

Ahn K.

Fabbrini E.

Klein S.

et al. Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver. J. Lipid Res. 53 : 990-999 View in Article Scopus (57)

PubMed

Crossref

Google Scholar

Hall A.M.

Soufi N.

Chambers K.T.

Chen Z.

Schweitzer G.G.

McCommis K.S.

Erion D.M.

Graham M.J.

Su X.

Finck B.N. Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice. Diabetes. 63 : 2284-2296 View in Article Scopus (35)

PubMed

Crossref

Google Scholar

Harriman G.

Greenwood J.

Bhat S.

Huang X.

Wang R.

Paul D.

Tong L.

Saha A.K.

Westlin W.F.

Kapeller R.

Harwood Jr., H.J. Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats. Proc. Natl. Acad. Sci. USA. 113 : E1796-E1805 View in Article Scopus (100)

PubMed

Crossref

Google Scholar

Harrison S.A.

Abdelmalek M.F.

Trotter J.F.

Paredes A.H.

Arnold H.L.

Kugelmas M.

Bashir M.R.

Ling L.

Rossi S.J.

DePaoli A.M.

et al. LBO-07 - NGM282, a novel variant of FGF19, significantly reduces hepatic steatosis and key biomarkers of NASH: results of a Phase 2, multicenter, randomized, double-blinded, placebo controlled trial in biopsy-confirmed NASH patients. J. Hepatol. 66 : S92-S93 View in Article Abstract

Full Text PDF

Google Scholar

Harwood Jr., H.J.

Petras S.F.

Shelly L.D.

Zaccaro L.M.

Perry D.A.

Makowski M.R.

Hargrove D.M.

Martin K.A.

Tracey W.R.

Chapman J.G.

et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J. Biol. Chem. 278 : 37099-37111 View in Article Scopus (188)

PubMed

Crossref

Google Scholar

Henderson S.J.

Konkar A.

Hornigold D.C.

Trevaskis J.L.

Jackson R.

Fritsch Fredin M.

Jansson-Löfmark R.

Naylor J.

Rossi A.

Bednarek M.A.

et al. Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates. Diabetes Obes. Metab. 18 : 1176-1190 View in Article Scopus (81)

PubMed

Crossref

Google Scholar

Huard K.

Londregan A.T.

Tesz G.

Bahnck K.B.

Magee T.V.

Hepworth D.

Polivkova J.

Coffey S.B.

Pabst B.A.

Gosset J.R.

et al. Discovery of selective small molecule inhibitors of monoacylglycerol acyltransferase 3. J. Med. Chem. 58 : 7164-7172 View in Article Scopus (4)

PubMed

Crossref

Google Scholar

Hwang Y.C.

Hayashi T.

Fujimoto W.Y.

Kahn S.E.

Leonetti D.L.

McNeely M.J.

Boyko E.J. Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype. Int. J. Obes. 39 : 1365-1370 View in Article PubMed

Crossref

Google Scholar

Imamura M.

Takahashi A.

Yamauchi T.

Hara K.

Yasuda K.

Grarup N.

Zhao W.

Wang X.

Huerta-Chagoya A.

Hu C.

et al. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat. Commun. 7 : 10531 View in Article PubMed

Crossref

Google Scholar

Imbriglio J.E.

Shen D.M.

Liang R.

Marby K.

You M.

Youm H.W.

Feng Z.

London C.

Xiong Y.

Tata J.

et al. Discovery and pharmacology of a novel class of diacylglycerol acyltransferase 2 inhibitors. J. Med. Chem. 58 : 9345-9353 View in Article Scopus (16)

PubMed

Crossref

Google Scholar

Inzucchi S.E.

Maggs D.G.

Spollett G.R.

Page S.L.

Rife F.S.

Walton V.

Shulman G.I. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N. Engl. J. Med. 338 : 867-872 View in Article Scopus (669)

PubMed

Crossref

Google Scholar

Irimia J.M.

Meyer C.M.

Segvich D.M.

Surendran S.

DePaoli-Roach A.A.

Morral N.

Roach P.J. Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. J. Biol. Chem. 292 : 10455-10464 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Itani S.I.

Ruderman N.B.

Schmieder F.

Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 51 : 2005-2011 View in Article PubMed

Crossref

Google Scholar

Jiang G.

Li Z.

Liu F.

Ellsworth K.

Dallas-Yang Q.

Wu M.

Ronan J.

Esau C.

Murphy C.

Szalkowski D.

et al. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J. Clin. Invest. 115 : 1030-1038 View in Article Scopus (227)

PubMed

Crossref

Google Scholar

Jiang C.

Xie C.

Lv Y.

Li J.

Krausz K.W.

Shi J.

Brocker C.N.

Desai D.

Amin S.G.

Bisson W.H.

et al. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat. Commun. 6 : 10166 View in Article Scopus (177)

PubMed

Crossref

Google Scholar

Jornayvaz F.R.

Birkenfeld A.L.

Jurczak M.J.

Kanda S.

Guigni B.A.

Jiang D.C.

Zhang D.

Lee H.Y.

Samuel V.T.

Shulman G.I. Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2. Proc. Natl. Acad. Sci. USA. 108 : 5748-5752 View in Article Scopus (107)

PubMed

Crossref

Google Scholar

Kadowaki T.

Sekikawa A.

Murata K.

Maegawa H.

Takamiya T.

Okamura T.

El-Saed A.

Miyamatsu N.

Edmundowicz D.

Kita Y.

et al. Japanese men have larger areas of visceral adipose tissue than Caucasian men in the same levels of waist circumference in a population-based study. Int. J. Obes. 30 : 1163-1165 View in Article Scopus (136)

PubMed

Crossref

Google Scholar

Kelley D.E.

McKolanis T.M.

Hegazi R.A.

Kuller L.H.

Kalhan S.C. Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 285 : E906-E916 View in Article PubMed

Crossref

Google Scholar

Kim C.W.

Moon Y.A.

Park S.W.

Cheng D.

Kwon H.J.

Horton J.D. Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis. Proc. Natl. Acad. Sci. USA. 107 : 9626-9631 View in Article Scopus (71)

PubMed

Crossref

Google Scholar

Kir S.

Beddow S.A.

Samuel V.T.

Miller P.

Previs S.F.

Suino-Powell K.

Xu H.E.

Shulman G.I.

Kliewer S.A.

Mangelsdorf D.J. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science. 331 : 1621-1624 View in Article Scopus (314)

PubMed

Crossref

Google Scholar

Krssak M.

Falk Petersen K.

Dresner A.

DiPietro L.

Vogel S.M.

Rothman D.L.

Roden M.

Shulman G.I. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 42 : 113-116 View in Article Scopus (932)

PubMed

Crossref

Google Scholar

Kumashiro N.

Erion D.M.

Zhang D.

Kahn M.

Beddow S.A.

Chu X.

Still C.D.

Gerhard G.S.

Han X.

Dziura J.

et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc. Natl. Acad. Sci. USA. 108 : 16381-16385 View in Article Scopus (307)

PubMed

Crossref

Google Scholar

Kumashiro N.

Yoshimura T.

Cantley J.L.

Majumdar S.K.

Guebre-Egziabher F.

Kursawe R.

Vatner D.F.

Fat I.

Kahn M.

Erion D.M.

et al. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology. 57 : 1763-1772 View in Article Scopus (52)

PubMed

Crossref

Google Scholar

Lallukka S.

Yki-Järvinen H. Non-alcoholic fatty liver disease and risk of type 2 diabetes. Best Pract. Res. Clin. Endocrinol. Metab. 30 : 385-395 View in Article PubMed

Crossref

Google Scholar

Lazo M.

Solga S.F.

Horska A.

Bonekamp S.

Diehl A.M.

Brancati F.L.

Wagenknecht L.E.

Pi-Sunyer F.X.

Kahn S.E.

Clark J.M.

Fatty Liver Subgroup of the Look AHEAD Research Group Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care. 33 : 2156-2163 View in Article Scopus (172)

PubMed

Crossref

Google Scholar

Lewis G.F.

Zinman B.

Groenewoud Y.

Vranic M.

Giacca A. Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes. 45 : 454-462 View in Article PubMed

Crossref

Google Scholar

Lewis M.C.

Phillips M.L.

Slavotinek J.P.

Kow L.

Thompson C.H.

Toouli J. Change in liver size and fat content after treatment with Optifast very low calorie diet. Obes. Surg. 16 : 697-701 View in Article Scopus (138)

PubMed

Crossref

Google Scholar

Li S.

Brown M.S.

Goldstein J.L. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl. Acad. Sci. USA. 107 : 3441-3446 View in Article Scopus (422)

PubMed

Crossref

Google Scholar

Li J.Z.

Huang Y.

Karaman R.

Ivanova P.T.

Brown H.A.

Roddy T.

Castro-Perez J.

Cohen J.C.

Hobbs H.H. Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. J. Clin. Invest. 122 : 4130-4144 View in Article Scopus (152)

PubMed

Crossref

Google Scholar

Lim E.L.

Hollingsworth K.G.

Aribisala B.S.

Chen M.J.

Mathers J.C.

Taylor R. Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia. 54 : 2506-2514 View in Article Scopus (534)

PubMed

Crossref

Google Scholar

Linden M.A.

Sheldon R.D.

Meers G.M.

Ortinau L.C.

Morris E.M.

Booth F.W.

Kanaley J.A.

Vieira-Potter V.J.

Sowers J.R.

Ibdah J.A.

et al. Aerobic exercise training in the treatment of non-alcoholic fatty liver disease related fibrosis. J. Physiol. 594 : 5271-5284 View in Article Scopus (20)

PubMed

Crossref

Google Scholar

Lindquist C.

Bjørndal B.

Rossmann C.R.

Tusubira D.

Svardal A.

Røsland G.V.

Tronstad K.J.

Hallström S.

Berge R.K. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. J. Lipid Res. 58 : 1362-1373 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Liu J.

McLaren D.G.

Chen D.

Kan Y.

Stout S.J.

Shen X.

Murphy B.A.

Forrest G.

Karanam B.

Sonatore L.

et al. Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor. Pharmacol. Res. Perspect. 3 : e00193 View in Article Scopus (5)

PubMed

Crossref

Google Scholar

Lockie S.H.

Heppner K.M.

Chaudhary N.

Chabenne J.R.

Morgan D.A.

Veyrat-Durebex C.

Ananthakrishnan G.

Rohner-Jeanrenaud F.

Drucker D.J.

DiMarchi R.

et al. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes. 61 : 2753-2762 View in Article Scopus (128)

PubMed

Crossref

Google Scholar

Lotta L.A.

Gulati P.

Day F.R.

Payne F.

Ongen H.

van de Bunt M.

Gaulton K.J.

Eicher J.D.

Sharp S.J.

Luan J.

et al.

EPIC-InterAct Consortium

Cambridge FPLD1 Consortium Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat. Genet. 49 : 17-26 View in Article Scopus (191)

PubMed

Crossref

Google Scholar

Maciejewski B.S.

LaPerle J.L.

Chen D.

Ghosh A.

Zavadoski W.J.

McDonald T.S.

Manion T.B.

Mather D.

Patterson T.A.

Hanna M.

et al. Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans. Am. J. Physiol. Gastrointest. Liver Physiol. 304 : G958-G969 View in Article Scopus (20)

PubMed

Crossref

Google Scholar

Maggs D.G.

Buchanan T.A.

Burant C.F.

Cline G.

Gumbiner B.

Hsueh W.A.

Inzucchi S.

Kelley D.

Nolan J.

Olefsky J.M.

et al. Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 128 : 176-185 View in Article PubMed

Crossref

Google Scholar

Magkos F.

Fabbrini E.

Mohammed B.S.

Patterson B.W.

Klein S. Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction. Obesity (Silver Spring). 18 : 1510-1515 View in Article Scopus (62)

PubMed

Crossref

Google Scholar

Mahdessian H.

Taxiarchis A.

Popov S.

Silveira A.

Franco-Cereceda A.

Hamsten A.

Eriksson P.

van’t Hooft F. TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. Proc. Natl. Acad. Sci. USA. 111 : 8913-8918 View in Article Scopus (136)

PubMed

Crossref

Google Scholar

Mancina R.M.

Matikainen N.

Maglio C.

Söderlund S.

Lundbom N.

Hakkarainen A.

Rametta R.

Mozzi E.

Fargion S.

Valenti L.

et al. Paradoxical dissociation between hepatic fat content and de novo lipogenesis due to PNPLA3 sequence variant. J. Clin. Endocrinol. Metab. 100 : E821-E825 View in Article PubMed

Crossref

Google Scholar

Mao J.

DeMayo F.J.

Li H.

Abu-Elheiga L.

Gu Z.

Shaikenov T.E.

Kordari P.

Chirala S.S.

Heird W.C.

Wakil S.J. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc. Natl. Acad. Sci. USA. 103 : 8552-8557 View in Article Scopus (181)

PubMed

Crossref

Google Scholar

Markan K.R.

Naber M.C.

Ameka M.K.

Anderegg M.D.

Mangelsdorf D.J.

Kliewer S.A.

Mohammadi M.

Potthoff M.J. Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding. Diabetes. 63 : 4057-4063 View in Article Scopus (228)

PubMed

Crossref

Google Scholar

Martagón A.J.

Lin J.Z.

Cimini S.L.

Webb P.

Phillips K.J. The amelioration of hepatic steatosis by thyroid hormone receptor agonists is insufficient to restore insulin sensitivity in ob/ob mice. PLoS ONE. 10 : e0122987 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Mattar S.G.

Velcu L.M.

Rabinovitz M.

Demetris A.J.

Krasinskas A.M.

Barinas-Mitchell E.

Eid G.M.

Ramanathan R.

Taylor D.S.

Schauer P.R. Surgically-induced weight loss significantly improves nonalcoholic fatty liver disease and the metabolic syndrome. Ann. Surg. 242 ( ) : 610-617 View in Article PubMed

Google Scholar

Mayerson A.B.

Hundal R.S.

Dufour S.

Lebon V.

Befroy D.

Cline G.W.

Enocksson S.

Inzucchi S.E.

Shulman G.I.

Petersen K.F. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes. 51 : 797-802 View in Article PubMed

Crossref

Google Scholar

McCommis K.S.

Hodges W.T.

Brunt E.M.

Nalbantoglu I.

McDonald W.G.

Holley C.

Fujiwara H.

Schaffer J.E.

Colca J.R.

Finck B.N. Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis. Hepatology. 65 : 1543-1556 View in Article Scopus (42)

PubMed

Crossref

Google Scholar

Meyers C.D.

Tremblay K.

Amer A.

Chen J.

Jiang L.

Gaudet D. Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome. Lipids Health Dis. 14 : 8 View in Article PubMed

Crossref

Google Scholar

Miles J.M.

Wooldridge D.

Grellner W.J.

Windsor S.

Isley W.L.

Klein S.

Harris W.S. Nocturnal and postprandial free fatty acid kinetics in normal and type 2 diabetic subjects: effects of insulin sensitization therapy. Diabetes. 52 : 675-681 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Miyazaki Y.

Mahankali A.

Matsuda M.

Mahankali S.

Hardies J.

Cusi K.

Mandarino L.J.

DeFronzo R.A. Effect of pioglitazone on abdominal fat distribution and insulin sensitivity in type 2 diabetic patients. J. Clin. Endocrinol. Metab. 87 : 2784-2791 View in Article Scopus (563)

PubMed

Crossref

Google Scholar

Mori Y.

Murakawa Y.

Okada K.

Horikoshi H.

Yokoyama J.

Tajima N.

Ikeda Y. Effect of troglitazone on body fat distribution in type 2 diabetic patients. Diabetes Care. 22 : 908-912 View in Article Scopus (238)

PubMed

Crossref

Google Scholar

Nagashima K.

Lopez C.

Donovan D.

Ngai C.

Fontanez N.

Bensadoun A.

Fruchart-Najib J.

Holleran S.

Cohn J.S.

Ramakrishnan R.

Ginsberg H.N. Effects of the PPARgamma agonist pioglitazone on lipoprotein metabolism in patients with type 2 diabetes mellitus. J. Clin. Invest. 115 : 1323-1332 View in Article Scopus (156)

PubMed

Crossref

Google Scholar

Nagata N.

Xu L.

Kohno S.

Ushida Y.

Aoki Y.

Umeda R.

Fuke N.

Zhuge F.

Ni Y.

Nagashimada M.

et al. Glucoraphanin ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. Diabetes. 66 : 1222-1236 View in Article Scopus (1)

PubMed

Crossref

Google Scholar

Nazare J.A.

Smith J.D.

Borel A.L.

Haffner S.M.

Balkau B.

Ross R.

Massien C.

Alméras N.

Després J.P. Ethnic influences on the relations between abdominal subcutaneous and visceral adiposity, liver fat, and cardiometabolic risk profile: the International Study of Prediction of Intra-Abdominal Adiposity and Its Relationship With Cardiometabolic Risk/Intra-Abdominal Adiposity. Am. J. Clin. Nutr. 96 : 714-726 View in Article Scopus (171)

PubMed

Crossref

Google Scholar

Nielsen S.

Guo Z.

Johnson C.M.

Hensrud D.D.

Jensen M.D. Splanchnic lipolysis in human obesity. J. Clin. Invest. 113 : 1582-1588 View in Article PubMed

Crossref

Google Scholar

Okuma C.

Ohta T.

Tadaki H.

Hamada H.

Oda T.

Taniuchi H.

Yamanaka K.

Ishii Y.

Ohe Y.

Yata S.

et al. JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur. J. Pharmacol. 758 : 72-81 View in Article Scopus (8)

PubMed

Crossref

Google Scholar

Okuma C.

Ohta T.

Tadaki H.

Ishigure T.

Sakata S.

Taniuchi H.

Sano R.

Hamada H.

Kume S.

Nishiu J.

Kakutani M. JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J. Pharmacol. Sci. 128 : 150-157 View in Article Scopus (2)

PubMed

Crossref

Google Scholar

Olson D.P.

Pulinilkunnil T.

Cline G.W.

Shulman G.I.

Lowell B.B. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc. Natl. Acad. Sci. USA. 107 : 7598-7603 View in Article Scopus (76)

PubMed

Crossref

Google Scholar

Palmer A.K.

Kirkland J.L. Aging and adipose tissue: potential interventions for diabetes and regenerative medicine. Exp. Gerontol. 86 : 97-105 View in Article PubMed

Crossref

Google Scholar

Park J.G.

Xu X.

Cho S.

Hur K.Y.

Lee M.S.

Kersten S.

Lee A.H. CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis. Sci. Rep. 6 : 27938 View in Article PubMed

Crossref

Google Scholar

Perseghin G.

Price T.B.

Petersen K.F.

Roden M.

Cline G.W.

Gerow K.

Rothman D.L.

Shulman G.I. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N. Engl. J. Med. 335 : 1357-1362 View in Article Scopus (495)

PubMed

Crossref

Google Scholar

Perseghin G.

Scifo P.

De Cobelli F.

Pagliato E.

Battezzati A.

Arcelloni C.

Vanzulli A.

Testolin G.

Pozza G.

Del Maschio A.

Luzi L. Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes. 48 : 1600-1606 View in Article Scopus (652)

PubMed

Crossref

Google Scholar

Peter A.

Kantartzis K.

Machicao F.

Machann J.

Wagner S.

Templin S.

Königsrainer I.

Königsrainer A.

Schick F.

Fritsche A.

et al. Visceral obesity modulates the impact of apolipoprotein C3 gene variants on liver fat content. Int. J. Obes. 36 : 774-782 View in Article Scopus (26)

PubMed

Crossref

Google Scholar

Petersen K.F.

Hendler R.

Price T.

Perseghin G.

Rothman D.L.

Held N.

Amatruda J.M.

Shulman G.I. 13C/31P NMR studies on the mechanism of insulin resistance in obesity. Diabetes. 47 : 381-386 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Petersen K.F.

Laurent D.

Rothman D.L.

Cline G.W.

Shulman G.I. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. J. Clin. Invest. 101 : 1203-1209 View in Article PubMed

Crossref

Google Scholar

Petersen K.F.

Krssak M.

Inzucchi S.

Cline G.W.

Dufour S.

Shulman G.I. Mechanism of troglitazone action in type 2 diabetes. Diabetes. 49 : 827-831 View in Article PubMed

Crossref

Google Scholar

Petersen K.F.

Oral E.A.

Dufour S.

Befroy D.

Ariyan C.

Yu C.

Cline G.W.

DePaoli A.M.

Taylor S.I.

Gorden P.

Shulman G.I. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Invest. 109 : 1345-1350 View in Article PubMed

Crossref

Google Scholar

Petersen K.F.

Dufour S.

Befroy D.

Lehrke M.

Hendler R.E.

Shulman G.I. Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes. 54 : 603-608 View in Article Scopus (569)

PubMed

Crossref

Google Scholar

Petersen K.F.

Dufour S.

Savage D.B.

Bilz S.

Solomon G.

Yonemitsu S.

Cline G.W.

Befroy D.

Zemany L.

Kahn B.B.

et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc. Natl. Acad. Sci. USA. 104 : 12587-12594 View in Article Scopus (430)

PubMed

Crossref

Google Scholar

Petersen M.C.

Madiraju A.K.

Gassaway B.M.

Marcel M.

Nasiri A.R.

Butrico G.

Marcucci M.J.

Zhang D.

Abulizi A.

Zhang X.-M.

et al. Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J. Clin. Invest. 126 : 4361-4371 View in Article Scopus (70)

PubMed

Crossref

Google Scholar

Pingitore P.

Pirazzi C.

Mancina R.M.

Motta B.M.

Indiveri C.

Pujia A.

Montalcini T.

Hedfalk K.

Romeo S. Recombinant PNPLA3 protein shows triglyceride hydrolase activity and its I148M mutation results in loss of function. Biochim. Biophys. Acta. 1841 : 574-580 View in Article Scopus (84)

PubMed

Crossref

Google Scholar

Pocai A.

Carrington P.E.

Adams J.R.

Wright M.

Eiermann G.

Zhu L.

Du X.

Petrov A.

Lassman M.E.

Jiang G.

et al. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. Diabetes. 58 : 2258-2266 View in Article Scopus (180)

PubMed

Crossref

Google Scholar

Prager R.

Wallace P.

Olefsky J.M. Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes. 36 : 607-611 View in Article PubMed

Crossref

Google Scholar

Previs S.F.

Cline G.W.

Shulman G.I. A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo. Am. J. Physiol. 277 : E154-E160 View in Article PubMed

Google Scholar

Rabøl R.

Petersen K.F.

Dufour S.

Flannery C.

Shulman G.I. Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals. Proc. Natl. Acad. Sci. USA. 108 : 13705-13709 View in Article Scopus (99)

PubMed

Crossref

Google Scholar

Raddatz K.

Turner N.

Frangioudakis G.

Liao B.M.

Pedersen D.J.

Cantley J.

Wilks D.

Preston E.

Hegarty B.D.

Leitges M.

et al. Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice. Diabetologia. 54 : 1447-1456 View in Article Scopus (37)

PubMed

Crossref

Google Scholar

Raff E.J.

Kakati D.

Bloomer J.R.

Shoreibah M.

Rasheed K.

Singal A.K. Diabetes mellitus predicts occurrence of cirrhosis and hepatocellular cancer in alcoholic liver and non-alcoholic fatty liver diseases. J Clin Transl Hepatol. 3 : 9-16 View in Article PubMed

Crossref

Google Scholar

Rebrin K.

Steil G.M.

Mittelman S.D.

Bergman R.N. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J. Clin. Invest. 98 : 741-749 View in Article PubMed

Crossref

Google Scholar

Roden M.

Price T.B.

Perseghin G.

Petersen K.F.

Rothman D.L.

Cline G.W.

Shulman G.I. Mechanism of free fatty acid-induced insulin resistance in humans. J. Clin. Invest. 97 : 2859-2865 View in Article PubMed

Crossref

Google Scholar

Romeo S.

Kozlitina J.

Xing C.

Pertsemlidis A.

Cox D.

Pennacchio L.A.

Boerwinkle E.

Cohen J.C.

Hobbs H.H. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 40 : 1461-1465 View in Article Scopus (1551)

PubMed

Crossref

Google Scholar

Sampath H.

Flowers M.T.

Liu X.

Paton C.M.

Sullivan R.

Chu K.

Zhao M.

Ntambi J.M. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J. Biol. Chem. 284 : 19961-19973 View in Article Scopus (95)

PubMed

Crossref

Google Scholar

Samuel V.T.

Liu Z.X.

Wang A.

Beddow S.A.

Geisler J.G.

Kahn M.

Zhang X.M.

Monia B.P.

Bhanot S.

Shulman G.I. Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J. Clin. Invest. 117 : 739-745 View in Article Scopus (336)

PubMed

Crossref

Google Scholar

Santoro N.

Zhang C.K.

Zhao H.

Pakstis A.J.

Kim G.

Kursawe R.

Dykas D.J.

Bale A.E.

Giannini C.

Pierpont B.

et al. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. Hepatology. 55 : 781-789 View in Article Scopus (109)

PubMed

Crossref

Google Scholar

Sanyal A.J.

Chalasani N.

Kowdley K.V.

McCullough A.

Diehl A.M.

Bass N.M.

Neuschwander-Tetri B.A.

Lavine J.E.

Tonascia J.

Unalp A.

et al.

NASH CRN Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N. Engl. J. Med. 362 : 1675-1685 View in Article Scopus (1575)

PubMed

Crossref

Google Scholar

Sanyal A.

Charles E.D.

Neuschwander-Tetri B.A.

Loomba R.

Harrison S.

Abdelmalek M.

Lawitz E.

Halegoua-DeMarzio D.

Dong Y.

Noviello S.

et al. BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: a phase 2 study. J. Hepatol. 66 : S89-S90 View in Article Abstract

Full Text PDF

Google Scholar

Savage D.B.

Choi C.S.

Samuel V.T.

Liu Z.X.

Zhang D.

Wang A.

Zhang X.M.

Cline G.W.

Yu X.X.

Geisler J.G.

et al. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J. Clin. Invest. 116 : 817-824 View in Article Scopus (303)

PubMed

Crossref

Google Scholar

Schauer P.R.

Bhatt D.L.

Kirwan J.P.

Wolski K.

Aminian A.

Brethauer S.A.

Navaneethan S.D.

Singh R.P.

Pothier C.E.

Nissen S.E.

Kashyap S.R.

STAMPEDE Investigators Bariatric surgery versus intensive medical therapy for diabetes—5-year outcomes. N. Engl. J. Med. 376 : 641-651 View in Article Scopus (687)

PubMed

Crossref

Google Scholar

Schober G.

Arnold M.

Birtles S.

Buckett L.K.

Pacheco-López G.

Turnbull A.V.

Langhans W.

Mansouri A. Diacylglycerol acyltransferase-1 inhibition enhances intestinal fatty acid oxidation and reduces energy intake in rats. J. Lipid Res. 54 : 1369-1384 View in Article Scopus (28)

PubMed

Crossref

Google Scholar

Seghieri M.

Rebelos E.

Gastaldelli A.

Astiarraga B.D.

Casolaro A.

Barsotti E.

Pocai A.

Nauck M.

Muscelli E.

Ferrannini E. Direct effect of GLP-1 infusion on endogenous glucose production in humans. Diabetologia. 56 : 156-161 View in Article Scopus (72)

PubMed

Crossref

Google Scholar

Singal A.G.

Manjunath H.

Yopp A.C.

Beg M.S.

Marrero J.A.

Gopal P.

Waljee A.K. The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis. Am. J. Gastroenterol. 109 : 325-334 View in Article Scopus (162)

PubMed

Crossref

Google Scholar

Sinha R.

Dufour S.

Petersen K.F.

LeBon V.

Enoksson S.

Ma Y.-Z.

Savoye M.

Rothman D.L.

Shulman G.I.

Caprio S. Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes. 51 : 1022-1027 View in Article PubMed

Crossref

Google Scholar

Smagris E.

Gilyard S.

BasuRay S.

Cohen J.C.

Hobbs H.H. Inactivation of Tm6sf2, a gene defective in fatty liver disease, impairs lipidation but not secretion of very low density lipoproteins. J. Biol. Chem. 291 : 10659-10676 View in Article Scopus (61)

PubMed

Crossref

Google Scholar

Smith B.K.

Ford R.J.

Desjardins E.M.

Green A.E.

Hughes M.C.

Houde V.P.

Day E.A.

Marcinko K.

Crane J.D.

Mottillo E.P.

et al. Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK-β1. Diabetes. 65 : 3352-3361 View in Article Scopus (26)

PubMed

Crossref

Google Scholar

Soufi N.

Hall A.M.

Chen Z.

Yoshino J.

Collier S.L.

Mathews J.C.

Brunt E.M.

Albert C.J.

Graham M.J.

Ford D.A.

Finck B.N. Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice. J. Biol. Chem. 289 : 30177-30188 View in Article Scopus (23)

PubMed

Crossref

Google Scholar

Staels B.

Rubenstrunk A.

Noel B.

Rigou G.

Delataille P.

Millatt L.J.

Baron M.

Lucas A.

Tailleux A.

Hum D.W.

et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology. 58 : 1941-1952 View in Article Scopus (193)

PubMed

Crossref

Google Scholar

Stephens L.

Anderson K.

Stokoe D.

Erdjument-Bromage H.

Painter G.F.

Holmes A.B.

Gaffney P.R.J.

Reese C.B.

McCormick F.

Tempst P.

et al. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science. 279 : 710-714 View in Article Scopus (867)

PubMed

Crossref

Google Scholar

Szendroedi J.

Yoshimura T.

Phielix E.

Koliaki C.

Marcucci M.

Zhang D.

Jelenik T.

Müller J.

Herder C.

Nowotny P.

et al. Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proc. Natl. Acad. Sci. USA. 111 : 9597-9602 View in Article Scopus (183)

PubMed

Crossref

Google Scholar

Thabet K.

Asimakopoulos A.

Shojaei M.

Romero-Gomez M.

Mangia A.

Irving W.L.

Berg T.

Dore G.J.

Grønbæk H.

Sheridan D.

et al.

International Liver Disease Genetics Consortium MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C. Nat. Commun. 7 : 12757 View in Article Scopus (36)

PubMed

Crossref

Google Scholar

Tomimoto D.

Okuma C.

Ishii Y.

Kobayashi A.

Ohta T.

Kakutani M.

Imanaka T.

Ogawa N. JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice. J. Pharmacol. Sci. 129 : 51-58 View in Article Scopus (3)

PubMed

Crossref

Google Scholar

Tonelli J.

Li W.

Kishore P.

Pajvani U.B.

Kwon E.

Weaver C.

Scherer P.E.

Hawkins M. Mechanisms of early insulin-sensitizing effects of thiazolidinediones in type 2 diabetes. Diabetes. 53 : 1621-1629 View in Article Scopus (212)

PubMed

Crossref

Google Scholar

Valdecantos M.P.

Pardo V.

Ruiz L.

Castro-Sánchez L.

Lanzón B.

Fernández-Millán E.

García-Monzón C.

Arroba A.I.

González-Rodríguez Á.

Escrivá F.

et al. A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice. Hepatology. 65 : 950-968 View in Article Scopus (29)

PubMed

Crossref

Google Scholar

Vatner D.F.

Weismann D.

Beddow S.A.

Kumashiro N.

Erion D.M.

Liao X.H.

Grover G.J.

Webb P.

Phillips K.J.

Weiss R.E.

et al. Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. Am. J. Physiol. Endocrinol. Metab. 305 : E89-E100 View in Article Scopus (47)

PubMed

Crossref

Google Scholar

Vatner D.F.

Majumdar S.K.

Kumashiro N.

Petersen M.C.

Rahimi Y.

Gattu A.K.

Bears M.

Camporez J.P.

Cline G.W.

Jurczak M.J.

et al. Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. Proc. Natl. Acad. Sci. USA. 112 : 1143-1148 View in Article Scopus (97)

PubMed

Crossref

Google Scholar

Viscoli C.M.

Inzucchi S.E.

Young L.H.

Insogna K.L.

Conwit R.

Furie K.L.

Gorman M.

Kelly M.A.

Lovejoy A.M.

Kernan W.N.

IRIS Trial Investigators Pioglitazone and risk for bone fracture: safety data from a randomized clinical trial. J. Clin. Endocrinol. Metab. 102 : 914-922 View in Article PubMed

Google Scholar

Watanabe M.

Houten S.M.

Mataki C.

Christoffolete M.A.

Kim B.W.

Sato H.

Messaddeq N.

Harney J.W.

Ezaki O.

Kodama T.

et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature. 439 : 484-489 View in Article Scopus (1210)

PubMed

Crossref

Google Scholar

Wehmeyer M.H.

Zyriax B.C.

Jagemann B.

Roth E.

Windler E.

Schulze Zur Wiesch J.

Lohse A.W.

Kluwe J. Nonalcoholic fatty liver disease is associated with excessive calorie intake rather than a distinctive dietary pattern. Medicine (Baltimore). 95 : e3887 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Wei W.

Dutchak P.A.

Wang X.

Ding X.

Wang X.

Bookout A.L.

Goetz R.

Mohammadi M.

Gerard R.D.

Dechow P.C.

et al. Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ. Proc. Natl. Acad. Sci. USA. 109 : 3143-3148 View in Article Scopus (236)

PubMed

Crossref

Google Scholar

Wen W.

Kato N.

Hwang J.Y.

Guo X.

Tabara Y.

Li H.

Dorajoo R.

Yang X.

Tsai F.J.

Li S.

et al. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci. Rep. 6 : 17958 View in Article Scopus (29)

PubMed

Crossref

Google Scholar

Williams A.L.

Jacobs S.B.

Moreno-Macías H.

Huerta-Chagoya A.

Churchhouse C.

Márquez-Luna C.

García-Ortíz H.

Gómez-Vázquez M.J.

Burtt N.P.

Aguilar-Salinas C.A.

et al.

SIGMA Type 2 Diabetes Consortium Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature. 506 : 97-101 View in Article Scopus (248)

PubMed

Crossref

Google Scholar

Wueest S.

Item F.

Lucchini F.C.

Challa T.D.

Müller W.

Blüher M.

Konrad D. Mesenteric fat lipolysis mediates obesity-associated hepatic steatosis and insulin resistance. Diabetes. 65 : 140-148 View in Article PubMed

Google Scholar

Wynne K.

Park A.J.

Small C.J.

Patterson M.

Ellis S.M.

Murphy K.G.

Wren A.M.

Frost G.S.

Meeran K.

Ghatei M.A.

Bloom S.R. Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes. 54 : 2390-2395 View in Article Scopus (278)

PubMed

Crossref

Google Scholar

Xu J.

Lloyd D.J.

Hale C.

Stanislaus S.

Chen M.

Sivits G.

Vonderfecht S.

Hecht R.

Li Y.-S.

Lindberg R.A.

et al. Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes. 58 : 250-259 View in Article Scopus (686)

PubMed

Crossref

Google Scholar

Xu J.

Murphy S.L.

Kochanek K.D.

Arias E. Mortality in the United States, 2015. NCHS Data Brief. 267 : 1-8 View in Article Google Scholar

Yoshitaka H.

Hamaguchi M.

Kojima T.

Fukuda T.

Ohbora A.

Fukui M. Nonoverweight nonalcoholic fatty liver disease and incident cardiovascular disease: A post hoc analysis of a cohort study. Medicine (Baltimore). 96 : e6712 View in Article Scopus (23)

PubMed

Crossref

Google Scholar

Yu C.

Chen Y.

Cline G.W.

Zhang D.

Zong H.

Wang Y.

Bergeron R.

Kim J.K.

Cushman S.W.

Cooney G.J.

et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277 : 50230-50236 View in Article Scopus (1088)

PubMed

Crossref

Google Scholar

Zambad S.P.

Tuli D.

Mathur A.

Ghalsasi S.A.

Chaudhary A.R.

Deshpande S.

Gupta R.C.

Chauthaiwale V.

Dutt C. TRC210258, a novel TGR5 agonist, reduces glycemic and dyslipidemic cardiovascular risk in animal models of diabesity. Diabetes Metab. Syndr. Obes. 7 : 1-14 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Zhang X.

Yeung D.C.Y.

Karpisek M.

Stejskal D.

Zhou Z.-G.

Liu F.

Wong R.L.C.

Chow W.-S.

Tso A.W.K.

Lam K.S.L.

Xu A. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57 : 1246-1253 View in Article Scopus (534)

PubMed

Crossref

Google Scholar

Zhang Y.

Xie Y.

Berglund E.D.

Coate K.C.

He T.T.

Katafuchi T.

Xiao G.

Potthoff M.J.

Wei W.

Wan Y.

et al. The starvation hormone, fibroblast growth factor-21, extends lifespan in mice. eLife. 1 : e00065 View in Article Scopus (180)

PubMed

Crossref

Google Scholar

Zhang R.N.

Zheng R.D.

Mi Y.Q.

Zhou D.

Shen F.

Chen G.Y.

Zhu C.Y.

Pan Q.

Fan J.G. APOC3 rs2070666 is associated with the hepatic steatosis independently of PNPLA3 rs738409 in Chinese Han patients with nonalcoholic fatty liver diseases. Dig. Dis. Sci. 61 : 2284-2293 View in Article Scopus (0)

PubMed

Crossref

Google Scholar

Zhong Y.

Li X.

Yu D.

Li X.

Li Y.

Long Y.

Yuan Y.

Ji Z.

Zhang M.

Wen J.G.

et al. Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro. Oncotarget. 6 : 37758-37769 View in Article Scopus (0)

PubMed

Crossref

Google Scholar