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At a Glance A man was found dead in a home in Cleveland, Ohio, as lake-effect snow and frigid temperatures swept across the Great Lakes.

A second fatality was reported in a crash in Oswego County, New York.

At least 50 vehicles were involved in a pileup that shut down Interstate 80 in Pennsylvania.

At least two deaths have been reported in Ohio and New York as heavy lake-effect snow affected several cities in at least four states in the Great Lakes area. The inclement weather triggered traffic nightmares, including a 50-vehicle pileup in Pennsylvania that shut down Interstate 80 Thursday.

The lake-effect snow is hitting one week after up to 3 feet of snow buried some of the same Great Lakes snow belts from central New York to Upper Michigan last week .

Pennsylvania

A multi-vehicle accident was reported Thursday morning on I-80 eastbound in Jefferson County near Falls Creek , reports the Pennsylvania Department of Transportation. Officials estimate that at least 59 vehicles were involved, including 22 tractor-trailers. Only three minor injuries were reported by police , according to WJAC. All lanes are closed and multiple emergency agencies have been dispatched to the scene, EYT Media reported.

Several other accidents were reported on I-80 as speed restrictions were imposed due to hazardous driving conditions.

Ohio

A man was found dead in a home in Cleveland early Thursday morning due to exposure to winter weather, according to NEWS 5 Cleveland.

The man's name was not immediately released. He was found in a residence on the 2100 block of East 68th Street, NEWS 5 also reports.

Whiteout conditions were being reported in northeastern Ohio on Thursday morning, including in Cleveland.

According to the National Weather Service, snowfall rates of up to 2 inches or more per hour with the heavier bands have made travel very difficult as visibility diminished

(FORECAST: Lake-Effect Snow Updates )

The snowfall caused massive delays on roads and highways throughout northeastern Ohio and has prompted hundreds of schools to close, according to the Cleveland Plain Dealer.

Broken-down vehicles are being reported on Interstate 90 eastbound, the Ohio Department of Transportation, adding that delays are expected throughout the morning.

New York

One death was reported Thursday in Oswego County following a two-car crash on snowy roads.

Officials told Syracuse.com that a man, whose name has not been released, died when two cars collided on Route 57 in Schroeppel just before 10 a.m. EST Thursday morning. Authorities believe the crash was due to the poor weather, and the stretch of Route 57 was closed for hours, the report added.

Snowfall made travel dangerous in the Empire State, including parts of the Adirondack Northway north of Albany, which had to be closed for more than four hours after a crash involving a tractor-trailer and a snowplow. There were no injuries reported.

Wednesday officials were forced to close the Skyway, as well as a portion of Route 5 , according to the Buffalo News.

Near Cheektowaga, thundersnow was reported Wednesday afternoon, the report added.

(MORE: Winter Storm Decima Triggers Avalanche in Oregon )

"A persistent band of lake-effect snow from Lake Erie and Lake Ontario continues to pummel western New York," said weather.com meteorologist Jonathan Belles . "Parts of southern Buffalo saw 5 inches of snow in 90 minutes this afternoon, and snow totals continue to climb to near a half-foot to the northeast of Buffalo."

Northeast of Buffalo, heavy snow also impacted travel in the Watertown area. WWNY-TV said there were a slew of incidents on snow-covered roadways Wednesday, one of which involved Louis Rivera, whose car went into a ditch following a spinout.

"Kinda just started stepping on the breaks, tapping it a little bit," Rivera told WWNY. "Then the white patches of ice got me and next you know I got sucked into this ditch over here, and I hit the stop sign."

Michigan

Whiteout conditions and slippery roads were being reported in parts of Michigan on Thursday morning, according to 9 & 10 News.

Three snowplows slid off the road in Chippewa County, reports the county's central dispatch. In Grand Traverse County, multiple vehicles have slid off roadways, including a tractor-trailer that is blocking a lane on M72.

The heaviest snow accumulation thus far has been reported in Sault Ste. Marie, which picked up 11 inches of snow in 18 hours, according to weather.com chief meteorologist Jonathan Erdman.