A new chemotherapy drug targets the structures that hold cancer cells together, potentially causing all types of cancerous tumors to self-destruct. Researchers at the University of New South Wales (UNSW) in Australia have developed a new drug that may be a cancer cure-all. The drug, called TR100, works by attacking the proteins that form the structure of cancer cells, while leaving healthy cells alone. Their study, which involved tests on lab rats, was published this month in Cancer Research. Help Friends and Family with Their Medical Costs: Raise Money Now » Like a building, cells need support structures in order to hold their shape. Two proteins called actin and myosin give cancer cells their structure; they are like long, tough, interlocking cables.



Healthy human muscle cells, including the cells that form the heart, also employ actin and myosin. For this reason, most researchers had abandoned actin and myosin as targets for chemotherapy, and the development of drugs targeting these proteins stalled for nearly 25 years. But world myosin specialist Dr. Peter Gunning pressed on, and now his work has yielded results. He and other researchers were able to isolate two specific types of myosin, called tropomyosins, which cancer cells use but healthy muscle cells don’t. He worked with Dr. Justine Stehn, the paper’s lead author, to develop TR100.

Programmed Cell Death: Making Tumors Implode “We’ve really gone after the core component of the internal scaffold or structure of the cancer cell,” said Stehn, a research fellow in the Oncology Research Unit at the UNSW School of Medical Sciences, in an interview with Healthline. “[When] the cell senses that there’s something fundamentally wrong with its architecture, it will undergo programmed cell death.” Programmed cell death is a genetic time bomb lurking inside each cell in the human body. If a cell is damaged, infected, or otherwise no longer working properly, the body can signal it to self-destruct. “It’s like when you see a building collapse,” said Stehn. “If you take out the structure and the scaffolds, the building will fall in on itself.”



Programmed death causes the cell to break itself down into tidy little packets of material that other cells can absorb, recycle, and reuse. TR100 appears to trigger this progress in cancer cells by destroying the two tropomyosins that cancer uses. However, stem cells also rely on this form of tropomyosin. Stem cells are active in a developing embryo, generating all of the new cells that will eventually form a healthy baby.



“When a cell is proliferating or growing, tropomyosin is really important,” said Stehn. “When a cell differentiates and becomes a heart cell, a lung cell, or a brain cell, it’s no longer growing, and the role of tropomyosin changes and targeting it with [TR100] is no longer toxic.”