Two men have died in a tragic chain of events involving two separate crashes, one in which an ambulance crashed in Melbourne's north-west.

Emergency services were called to help a 26-year-old motorcyclist who had lost control and collided with a car in Ascot Vale about 3.10pm on Wednesday. He later died in hospital.



An ambulance was sent to the scene, but while en route it was involved in a horror crash in Flemington.

Police said the ambulance was "performing urgent duty driving" when it collided with the side of a blue Toyota Yaris, pushing it towards a tram stop on Racecourse Road about 3.25pm.

The Toyota then struck a 58-year-old man from Kensington who was standing at the tram stop.