Reported US coronavirus deaths hit a record one-day total of 4,591 in 24 hours on Thursday, surpassing a previous high of 2,569 deaths in the U.S. on Wednesday, according to a Wall Street Journal analysis of data from Johns Hopkins University.

The number of new coronavirus cases on Thursday was approximately the same as Wednesday, with 31,451 new confirmed infections across the country, according to the outlet.

There have been more than 671,000 confirmed coronavirus cases in the U.S. since the outbreak began in China late last year. There have been more than 33,000 deaths. Around the world, there have been more than 2.15 million cases.

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The spike came on the same day that President Trump Donald John TrumpUS reimposes UN sanctions on Iran amid increasing tensions Jeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Trump supporters chant 'Fill that seat' at North Carolina rally MORE unveiled guidance for a phased reopening of parts of the U.S. economy that largely leaves final decisions to governors across the country.

The guidance recommends that states see a downward trajectory in the number of confirmed cases and flu-like symptoms before moving to lift the stay-at-home orders and other restrictions in states nationwide intended to stem the spread of the virus.

Multiple regional coalitions formed this week as state officials confer with one another on the best course for lifting advisories, including in the Northeast, along the West Coast and in a group of seven Midwestern states.