On October 12, 2010, the Supreme Court declined (PDF, p. 12) to review Association of Christian Schools International et al. v. Roman Stearns et al. , thus bringing the case to a definitive end. The case, originally filed in federal court in Los Angeles on August 25, 2005, centered on the University of California system's policies and statements relevant to evaluating the qualifications of applicants for admission. The plaintiffs — the Association of Christian Schools International, the Calvary Chapel Christian School in Murrieta, California, and a handful of students at the school — charged that the university system violated the constitutional rights of applicants from Christian schools whose high school coursework is deemed inadequate preparation for college.

Creationism was prominent in the case. The plaintiffs objected to the university system's policy of rejecting high school biology courses that use creationist textbooks as "inconsistent with the viewpoints and knowledge generally accepted in the scientific community." Michael Behe, a proponent of "intelligent design" creationism, served as a scientific expert witness for the plaintiffs, although his defense of the creationist biology textbooks was unavailing. Wendell Bird, one of the attorneys for the plaintiffs, is a former employee of the Institute for Creation Research; he defended Louisiana's 1981 "equal time" act all the way to the Supreme Court, where it was ruled to violate the Establishment Clause in the decision in Edwards v. Aguillard (1987).