The $270 million John R. Oishei Children’s Hospital will open next week on the Buffalo Niagara Medical Campus, capping off years of planning to replace Women & Children’s Hospital on Bryant Street.

A marathon one-day move will begin before dawn Nov. 10 to move patients and staff into the 185-bed hospital 1.2 miles away at 818 Ellicott St.

The new Children’s Hospital is smaller than the old one, with 15 fewer beds and significantly less square footage, at 410,395 total square feet, compared to 608,830. It is connected by a pedestrian skybridge to two floors of clinics and an outpatient surgery center in the adjacent Conventus building, as well as Buffalo General Medical Center and the Jacobs Institute.

Women & Children’s Hospital, which opened in 1892 with 12 beds in a renovated home on Bryant Street,was the first pediatric hospital in New York State. As it expanded over the years, new buildings were added and aging ones were replaced on a campus that stretched three city blocks.

At 12 stories high, the new hospital was designed by Shepley Bulfinch in Boston and built by Turner Construction Co. to be more efficient and patient-friendly in its layout and equipment placement. Patient rooms wrap along the outside edge of the building, with windows offering city views.