Taking a spin around the NFL to get you ready for Week 1:

The biggest questions going into Sunday

What will the New England Patriots look like with Jimmy Garoppolo?

While Garoppolo has been spending his time preparing for the Arizona Cardinals, Tom Brady is getting a taste of an alternate universe where he has to do common-man things like pick his kids up from school.

The Patriots are without Brady for four games. And Rob Ninkovich too. They traded away their best pass-rusher from a year ago in Chandler Jones. Yet going into the season, Vegas has them as Super Bowl favorites at 6-1.

Can Dak Prescott save the Dallas Cowboys' season?

Tony Romo's most recent injury has taken Cowboys owner and general manager Jerry Jones to a strange place.

Jerry Jones indicated the Cowboys will keep Tony Romo on the team's active roster. https://t.co/z34A7F7Myf pic.twitter.com/wwwVGRDsCi — NFL on ESPN (@ESPNNFL) September 6, 2016

According to ESPN Stats & Information, since 2013, in games without Romo, the Cowboys are 1-13. But Prescott's preseason (39-for-50 for 454 yards and five touchdowns) has them hopeful the season can be salvaged.

What can Browns coach Hue Jackson get out of Robert Griffin III?

More people have bet on the Cleveland Browns to win the Super Bowl than 11 other teams. If we can somehow track down who these people are, we might discover the most interesting subset of Americans this country has ever seen.

Griffin is the Browns' 25th starting quarterback since 1999, the most of any team in the NFL over that span. As noted by Luke Knox, the first 24 were mostly bad.

Will Sam Bradford get the start for the Vikings?

Mike Zimmer is not saying whether Bradford will be ready or the team will go with Shaun Hill.

Bradford has had more excuses made for him than any other quarterback in recent memory. If the mediocrity we've seen through his first 63 career starts continues Sunday, expect to hear plenty about how he only had one week to learn a new offense.

What you missed

Bill Barnwell identifies how each team can win the Super Bowl. ... Forty-two ESPN commentators make their Super Bowl predictions. ... John Clayton provides his preseason All-Pro team. ... Matt Bowen with the best one-on-one matchups of the season. ... And we answer your fantasy questions.

Numbers that matter

26.6: The average rank of Steve Spagnuolo's defenses the past five times he's been a head coach or a defensive coordinator, per Football Outsiders' DVOA rankings. He's back for another season with the New York Giants, and the team spent $105.3 million in guaranteed money on cornerback Janoris Jenkins, defensive lineman Olivier Vernon and defensive tackle Damon Harrison. Spagnuolo's defense finished 30th in DVOA last season, but the decision-makers clearly felt the issue was talent, not coaching. For the Giants to win the NFC East, Spagnuolo will have to prove them right.

86.6: Mark Sanchez's passer rating since the start of 2014. That's almost identical to Bradford's number (86.4). The Vikings traded a first- and a fourth-round pick for Bradford. The Cowboys signed Sanchez without giving up anything.

So what's the difference? Coaches still feel like they can be the ones to get something out of Bradford. They seem to be accepting of who Sanchez is at this point in his career.

45.1: The Cardinals' blitz percentage in 2015. No defense sent pressure at a higher rate than the one Garoppolo faces in his first NFL start.

Take a look

It remains to be seen whether Prince Amukamara will be a difference-maker in Jacksonville, but let's all pause to appreciate his planning and commitment in re-enacting a scene from "The Lion King" when his son was born.

What we'll be talking about Monday

1. How the Eagles' pass rush showed up against RG III: Griffin has struggled in the face of pressure, and the Eagles' defensive line, led by Fletcher Cox, is the strength of the team.

2. How P90X worked wonders for Eddie Lacy: If the thought of Lacy and Tony Horton sharing a warm embrace after a Packers victory doesn't get you feeling fuzzy, you have no soul.

3. How the Indianapolis Colts still can't protect Andrew Luck: In 2015, only three teams produced sacks at a higher rate than Luck's Week 1 opponent, the Detroit Lions.