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Alarming research has revealed women who have unpredictable cycles in their mid-twenties were more likely to develop the killer disease decades later.

In a study of 15,000 women, with an average age of 26, roughly 13 per cent of them reported irregular periods, which could be an early sign of the life-threatening condition.

Over half a century, 116 developed ovarian cancer, 84 of whom died, the researchers report in the International Journal of Cancer.

Women with a history of menstrual irregularities were nearly twice as likely as females with normal periods to develop the disease and die from it by the age of 70.