ROCHESTER, Minn. --Mayo Clinic researchers have found that mild cognitive impairment, a disorder considered a strong early predictor of Alzheimer's disease, is prevalent among the elderly and increases with age and fewer years of education.

Findings from this study, funded by the National Institute on Aging, will be presented Tuesday, April 4, at the American Academy of Neurology meeting in San Diego.

The researchers randomly selected 3,957 people from the general population of Olmsted County, Minn., home of Mayo Clinic, for participation in this study. The researchers set out to find how many of those who did not have dementia might have mild cognitive impairment. To date, 1,116 people without dementia in the study have been evaluated.

The findings suggest that 12 percent of 70- to 89-year-olds in Olmsted County, Minn., have mild cognitive impairment. The prevalence of mild cognitive impairment increased with age, affecting 9 percent of those 70 to 79 and nearly 18 percent of those 80 to 89. The prevalence of mild cognitive impairment also varied according to years of education, ranging from 25 percent in those with up to eight years of education, 14 percent in those with nine to 12 years, 9 percent in those with 13 to 16 years, and 8.5 percent in those with greater than 16 years.

The researchers suggest that the increase of mild cognitive impairment with age found in this study parallels the risk elevation with age seen in previous studies of Alzheimer's disease.

"This means that 12 percent to 20 percent of the entire population of those over age 70 may have either mild cognitive impairment or dementia, which is quite significant," says Ronald Petersen, M.D., Ph.D., Mayo Clinic neurologist and study investigator. "These data have major implications for the future of the health care system and the aging of America."

Dr. Petersen adds that the increased risk for mild cognitive impairment with fewer years of e

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Contact: Lisa Lucier

newsbureau@mayo.edu

507-284-5005

Mayo Clinic

4-Apr-2006







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