A total of 50 motorists have allegedly tested positive for driving while under the influence of illicit drugs during a state-wide police operation in NSW designed to reduce the road toll.

Operation Saturation, a 12-day crackdown which ends on Wednesday, has resulted in 328 random drug tests with 50 positive results.

Those drivers have been banned from driving for 24 hours ahead of their court appearances.

Assistant Commissioner John Hartley, commander of the NSW Traffic and Highway Patrol, said the operation was focused on saving the lives of road users.

"Getting behind the wheel while under the influence of illicit drugs or alcohol seriously impairs your reaction times and ability to concentrate," Commissioner Hartley said.

"We need motorists to consider others when they are on the roads.

"Those that speed, drink or drug drive, not wear seat belts or correct helmets, are distracted by mobile phones, or are fatigued, place themselves, their passengers, and other road users at great risk."

Assistant Commissioner Hartley said this year's road toll was an improvement on last year's tally, and Operation Saturation was designed to send a safety message to all motorists in NSW.

"So far this year, 48 people have lost their lives from 44 fatal crashes on NSW roads," he said.

"That is eight crashes and four deaths down on this time last year."

Included among the traffic infringements was a 19-year-old P-plater allegedly detected riding a motorcycle on the Hume Highway at Mittagong at 210kph in a 110kph zone.

An 18-year-old P-plater was allegedly clocked at 151kph in an 80kph zone on Taren Point Road in southern Sydney and another P-plater also allegedly drove at 151kph in an 80kph zone on Picton Road at Wilton.