This article has no abstract; the first 100 words appear below.

Acetaminophen is the drug of choice for fever in young children. Pediatricians, parents, and caregivers consider it to be safe for most children when it is administered in accordance with the manufacturer’s directions for use. In 2000, however, concern was raised about the safety of acetaminophen as a result of the findings of a case–control study by Shaheen et al.1 that suggested that frequent use of acetaminophen (also known as paracetamol in the United Kingdom) among adults was associated with asthma, and among those who already had asthma, with more severe disease. The mechanism for this association was thought to . . .