The Green Bay Packers lost a football game and four starters to injury during a difficult afternoon at FedEx Field in Washington on Sunday.

Defensive lineman Muhammad Wilkerson, right tackle Bryan Bulaga, outside linebacker Nick Perry and right guard Justin McCray all exited the 31-17 loss with injuries.

Wilkerson injured his ankle, Bulaga departed with a back injury, Perry was evaluated for a concussion and McCray had a shoulder issue.

Linebacker Clay Matthews also left the game briefly but returned.

Of the four injuries, Wilkerson’s looks to be the most serious. He was carted off after an unfortunate collision in the first half and immediately ruled out. It’s possible his season could be over.

Quarterback Aaron Rodgers appeared to injure his hamstring during a run in the second half, but he said his hamstrings were fine after the game.