Key developments in the global coronavirus outbreak today include:

Known global death toll passes 225,000

According to researchers at Johns Hopkins University, at least 226,771 people have died around the world, while at least 3,187,919 have been infected. The figures are likely to underestimate the scale of the pandemic because of suspected official underreporting and differing statistical recording regimes.

Brazil sees record increase in cases

Brazil reports a record increase in cases, with its ministry of health confirming 6,276 more infections in a 24-hour period, taking the country’s total to 78,162.

It also suffers another 449 deaths in that time, raising its toll to at least 5,466 people since the outbreak began. Health specialists believe the real numbers are much higher.

Yemen reports new cases

Five more cases are found in Aden, in southern Yemen, raising the prospect that the war-ravaged country will soon also have an outbreak to contend with.

The country, already declared “the world’s worst humanitarian crisis” by the UN, has apparently avoided a large-scale epidemic thus far, with just a single case reported in early April in the southern government-controlled province of Hadramawt.

More cases of ‘Covid-linked’ syndrome in children

Doctors around the world report more cases of a rare, but potentially lethal, inflammatory syndrome in children that appears to be linked to coronavirus infections.

Nearly 100 cases of the unusual illness have emerged in at least six countries, with doctors in Britain, the US, France, Italy, Spain and Switzerland now reported to be investigating the condition.

US drug trial shows ‘clear cut’ effect, says top medic

While a Chinese trial demonstrated no “significant clinical benefits” to administering the antiviral drug remdesivir to Covid-19 patients, a separate trial in the US shows a “clear-cut” effect, according to the head of the US National Institute of Allergy and Infectious Diseases, Dr Anthony Fauci.

He hails it as proof a drug can block the coronavirus shortly after the medicine’s maker, Gilead Sciences, revealed it had met its primary goals. Fauci says the “data shows that remdesivir has a clear-cut, significant, positive effect in diminishing the time to recovery”, adding that it proves “that a drug can block this virus”.

Cyprus set to ease lockdown

Cyprus is poised to relax its lockdown restrictions, with the island’s Greek Cypriot president due to announce the time frame for the reversal of the measures. The island’s internationally recognised Greek-run south has been under strict lockdown since early March with policies including a nightly curfew.

Bosnia sees post-lockdown outbreak resurgence

The country reports its sharpest daily rise in new infections after its two autonomous regions gradually began to ease lockdowns.

There were 93 new infections and two deaths in the previous 24 hours, compared with 20 new infections a day earlier and 49 the day before that, officials say. The news will raise concern that lockdown measures need to be maintained to avoid second waves of infections.