The chairwoman of the Republican National Committee is warning GOP senators to learn from the example of those in President Trump's party who stood up against him and lost at the ballot box.

Ronna Romney McDaniel was speaking specifically Monday on "The Laura Ingraham Show" about Sen. Jeff Flake Jeffrey (Jeff) Lane FlakeJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Republican former Michigan governor says he's voting for Biden Maybe they just don't like cowboys: The president is successful, some just don't like his style MORE (R-Ariz) and his reelection chances next year. Flake has spoken out publicly against Trump recently, and McDaniel warned he could face the same fate as former Rep. Joe Heck (R-Nev.) and former Sen. Kelly Ayotte Kelly Ann AyotteBottom line Bottom line Bottom Line MORE (R-N.H.), both whom opposed Trump and lost Senate campaigns last year.

“If you look at 2016, the senators that did not support the President … they fell short in those Senate races,” she said. “There is a cautionary tale there because voters want you to support the president in his agenda."

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McDaniel added that RNC committee members have the ability to intervene in specific primary races, though they usually avoid it.

“It's just interesting from a party standpoint, we do have governance,” she said.

Flake has been a fierce critic of Trump, and has called on other members of the Republican party to speak out against the president's policies and rhetoric.

He is currently promoting a new book called "Conscience of a Conservative."

Allies of Trump have reportedly considered supporting primary challenges to Flake and Sen. Dean Heller Dean Arthur HellerOn The Trail: Democrats plan to hammer Trump on Social Security, Medicare Lobbying World Democrats spend big to put Senate in play MORE (Nev.), two of the more vulnerable Senate Republicans heading into 2018.