N.G.D. is an investigator in the South Carolina Center of Biomedical Research Excellence (COBRE) in Oxidants, Redox Balance and Stress Signaling (P20GM103542) and is a Research Scholar of the American Cancer Society (RSG-14-156-01-CDD). This work was also supported by NIH/NCI (1R41CA213488-01), the South Carolina Clinical & Translational Research Institute with an academic home at the Medical University of South Carolina (MUSC; UL1 RR029882 and UL1 TR000062), shared resources of the MUSC Hollings Cancer Center (P30 CA138313), and by the Hollings Cancer Center T32 Ruth L. Kirschstein National Research Service Award Training Program T32 (CA193201). We would also like to thank Pablo Sobrado at Virginia Tech for the generous gifts of the pVP56K vector and the TEV-containing pVP67K vector.

Author contributions

RMR, LR, RMD, HB, MES, and NGD performed research. ABR directed synthesis of E64FC26. JJM and CJC provided support for organic synthesis of E61 derivatives. YM provided support for ROS assays. MMC performed MS of proteins from pull-downs. MC and PLB directed Vk*Myc experiments. RMR and NGD designed research, analyzed data, and wrote the manuscript. All authors reviewed and authorized the final version.