In a study published Tuesday in the journal Frontiers in Behavioral Neuroscience, he and his colleagues found that sniffing linalool, an alcohol component of lavender odor, was kind of like popping a Valium. It worked on the same parts of a mouse’s brain, but without all the dizzying side effects. And it didn’t target parts of the brain directly from the bloodstream, as was thought. Relief from anxiety could be triggered just by inhaling through a healthy nose.

Their findings add to a growing body of research demonstrating anxiety-reducing qualities of lavender odors and suggest a new mechanism for how they work in the body. Dr. Kashiwadani believes this new insight is a key step in developing lavender-derived compounds like linalool for clinical use in humans.

[Like the Science Times page on Facebook. | Sign up for the Science Times newsletter.]

Dr. Kashiwadani and his colleagues became interested in learning how linalool might work for anti-anxiety while testing its effects on pain relief in mice. In this earlier study, they noticed that the presence of linalool seemed to calm mice.

In this study, they exposed mice to linalool vapor, wafting from filter paper inside a specially made chamber to see if the odor triggered relaxation. Mice on linalool were more open to exploring, indicating they were less anxious than normal mice. And they didn’t behave like they were drunk, as mice on benzodiazepines , a drug used to treat anxiety, or injected with linalool did

But the linalool didn’t work when they blocked the mice’s ability to smell, or when they gave the mice a drug that blocks certain receptors in the brain. This suggested that to work, linalool tickled odor-sensitive neurons in the nose that send signals to just the right spots in the brain — the same ones triggered by Valium.