At this stage, some of you may be asking, "Why do people think Loki is in trouble?" Well, the answer to that question rests in Loki's personal history with Thanos. The two extraterrestrial threats first started working together shortly before the events depicted in The Avengers, as Thanos entrusted Loki with the Mind Stone so that he could invade Earth and steal the Space Stone (a.k.a. The Tesseract). Thanks to Earth's Mightiest Heroes, Loki's plans were thwarted, as he not only failed to get the new stone for Thanos, but he also lost the one he had. Presumably the events in Avengers: Infinity War will depict the God of Mischief's first interaction with the Mad Titan since then, and it's hard to imagine the latter party being super happy with the former.