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Reid's comments come as Democrats later Wednesday are expected to renew their demand that GOP leadership cave in and give Supreme Court nominee Merrick Garland a hearing and a vote.

Reid routinely uses the Senate floor to lash out at Republicans over their stance and has remained adamant that his GOP colleagues will ultimately give in.

Reid added Wednesday that Republicans "are awaiting with gleeful anticipation" for Trump to fill the Supreme Court seat left vacant by Justice Antonin Scalia's death.

"They should be ashamed," he added. "If my Republican colleagues aren't embarrassed, they aren't thinking very well."

Republicans largely argue the Senate shouldn't take up Garland's nomination so close to an election. Instead, they want the next president to make the Supreme Court appointment.

They also point to a 1992 speech from Vice President Biden, then a senator from Delaware, who warned against taking up a hypothetical nominee in an election year. The White House has argued that Republicans are taking the speech out of context.