Congressional Republicans, who were bracing for major losses on Election Day, are now drafting an ambitious agenda that will seek to torpedo President Obama’s major accomplishments over the last eight years.

With Donald Trump Donald John TrumpOmar fires back at Trump over rally remarks: 'This is my country' Pelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Trump mocks Biden appearance, mask use ahead of first debate MORE’s shocking presidential victory and the GOP keeping control of the Senate and a comfortable majority in the House, the party is well-positioned to play offense in 2017.

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Republican lawmakers on Wednesday were already talking about reaching out to Democrats to put together a package to repeal key parts of the 2010 Affordable Care Act, known as ObamaCare, and replace it with other reforms, such as letting insurance companies sell across state lines.

Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellPelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Senate GOP aims to confirm Trump court pick by Oct. 29: report Trump argues full Supreme Court needed to settle potential election disputes MORE (R-Ky.) told reporters Wednesday that repealing ObamaCare will be one of the top priorities of the new Congress.

“It’s a pretty high item on our agenda as you know,” McConnell said. “I would be shocked if we didn’t move forward to keep our commitment to the American people.”

McConnell called it “the single worst piece of legislation among many pieces of legislation passed in the first two years of the Obama presidency. The sooner we can go in a different direction, the better.”

The GOP leader made his comments after speaking to Trump and Vice President-elect Mike Pence Michael (Mike) Richard PenceButtigieg stands in as Pence for Harris's debate practice Trump argues full Supreme Court needed to settle potential election disputes Pence adviser knocks ex-staffer who criticized Trump on COVID-19 MORE.

Rising ObamaCare premiums, announced this fall, provided Republicans some momentum.

McConnell declined to say whether Senate Republicans would repeal the landmark healthcare law with a party-line vote under a special process known as budgetary reconciliation. That would require only 51 votes. The new Congress will have 52 Senate Republicans.

One of McConnell’s biggest criticisms of Senate Democrats is that they passed the law in 2010 without any bipartisan buy-in.

One of his deputies, National Republican Senatorial Committee Chairman Roger Wicker Roger Frederick WickerBottom line Hillicon Valley: DOJ indicts Chinese, Malaysian hackers accused of targeting over 100 organizations | GOP senators raise concerns over Oracle-TikTok deal | QAnon awareness jumps in new poll Shakespeare Theatre Company goes virtual for 'Will on the Hill...or Won't They?' MORE (Miss.), told reporters earlier in the day that he hoped the special budgetary process might not be necessary and that Democrats might be willing to negotiate reforms.

“Let’s see if we can reach some sort of consensus with our Democrat friends on trying to make this repeal and replace [work],” Wicker said. “I would hope that members of the Democratic Party are looking at the election results … and also not only that but the premium increases and would understand that the American people are dissatisfied with this failed program.”

Many red-state Democrats are up for reelection in 2018, including Sens. Claire McCaskill Claire Conner McCaskillMomentum growing among Republicans for Supreme Court vote before Election Day Democratic-linked group runs ads in Kansas GOP Senate primary Trump mocked for low attendance at rally MORE (Mo.), Joe Manchin Joseph (Joe) ManchinThe Hill's Morning Report - Sponsored by Facebook - Trump, GOP allies prepare for SCOTUS nomination this week Trump meets with potential Supreme Court pick Amy Coney Barrett at White House Names to watch as Trump picks Ginsburg replacement on Supreme Court MORE (W.Va.), Joe Donnelly Joseph (Joe) Simon DonnellyTrump meets with potential Supreme Court pick Amy Coney Barrett at White House Names to watch as Trump picks Ginsburg replacement on Supreme Court Momentum growing among Republicans for Supreme Court vote before Election Day MORE (Ind.), Heidi Heitkamp Mary (Heidi) Kathryn HeitkampCentrists, progressives rally around Harris pick for VP 70 former senators propose bipartisan caucus for incumbents Susan Collins set to play pivotal role in impeachment drama MORE (N.D.) and Jon Tester Jonathan (Jon) TesterPence seeks to boost Daines in critical Montana Senate race This World Suicide Prevention Day, let's recommit to protecting the lives of our veterans Filibuster fight looms if Democrats retake Senate MORE (Mont.).

Trump has proposed replacing ObamaCare with health savings accounts and allowing people to purchase insurance across state lines in all 50 states.

Republicans have used reconciliation previously to get around the Senate’s filibuster and approve an ObamaCare repeal.

There’s a keen sense of urgency among Republican lawmakers, who realize after six years of split government that they have a rare opportunity before them.

McConnell said he expects the GOP-controlled Congress to work closely with Trump and to negotiate quietly behind the scenes over issues where they disagree, such as trade.

One major issue looming is the vacancy on the Supreme Court created in February when conservative Justice Antonin Scalia died.

Republicans expect Trump to nominate a conservative in Scalia’s mold whom they will move through Judiciary Committee hearings and to a floor vote in the first few months of 2017. Trump has floated conservative jurists such as Diane Sykes, a member of the 7th Circuit U.S. Court of Appeals, and William Pryor, a judge on the 11th Circuit Court.

It’s a dramatic turn from only a few days ago, when Republicans were bracing for a battle with Democrats over immigration reform and a liberal Supreme Court nominee.

GOP strategists, even ones close to the Trump campaign, gave themselves little chance of keeping the White House as recently as Tuesday afternoon. CNN’s Jim Acosta reported shortly before the polls closed that a Trump adviser confided that it would take a “miracle” to win.

Now pro-business proposals that seemed destined for partisan gridlock have a real chance of becoming law because Republicans control both ends of Pennsylvania Avenue. Wall Street rallied Wednesday and the Dow Jones industrial average hit an all-time high of 18,589.

On deck is an overhaul of the nation’s tax code that would close loopholes and cut rates, a major deregulatory push and tighter security along the U.S.-Mexico border.

McConnell said Wednesday that a broad package reforming tax rates for individuals, small businesses and corporations may be within reach next year — a goal many Republicans had given up on for the near term.

“He talked about tax reform,” McConnell said of Trump’s campaign pledges. “I think this is really important.”

Trump has proposed condensing the current seven tax brackets into three and lowering the rate for the nation’s highest income earners to 33 percent.

New York Sen. Charles Schumer Chuck SchumerSenate Democrats introduce legislation to probe politicization of pandemic response Schumer interrupted during live briefing by heckler: 'Stop lying to the people' Jacobin editor: Primarying Schumer would force him to fight Trump's SCOTUS nominee MORE, who is set to take over as Senate Democratic leader, had been negotiating a far more modest package with Speaker Paul Ryan Paul Davis RyanKenosha will be a good bellwether in 2020 At indoor rally, Pence says election runs through Wisconsin Juan Williams: Breaking down the debates MORE (R-Wis.) earlier this year in anticipation of Hillary Clinton Hillary Diane Rodham ClintonButtigieg stands in as Pence for Harris's debate practice Senate GOP sees early Supreme Court vote as political booster shot Poll: 51 percent of voters want to abolish the electoral college MORE winning.

The other top Trump priority is building a wall along the U.S.-Mexico border, which drew plenty of criticism on the campaign trail.

McConnell stopped short of committing to funding the construction of a massive wall running hundreds of miles through the desert but expressed strong support for tougher border security.

“We’re going to be talking to the president[-elect] about his agenda. Border security is important,” he said. “Achieving border security is something I think should be high on the list.”

Comprehensive immigration reform such as a path to citizenship for millions of illegal immigrants, which Democrat Clinton planned to move in her first 100 days in office if elected, is likely dead.

On the foreign policy front, GOP lawmakers are looking toward a tougher approach against radical Islamic terrorism and re-implementing sanctions against Iran.

Trump repeatedly bashed Clinton and Obama throughout the campaign for telegraphing its military plans, giving militants time to flee U.S. strikes. Trump has called for aggressive operations to destroy the Islamic State in Iraq and Syria. He has called for rebuilding the military and improving intelligence capabilities, which will likely require more funding from Congress.

Senate Republican Whip John Cornyn John CornynThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Liberal super PAC launches ads targeting vulnerable GOP senators over SCOTUS fight Senate GOP faces pivotal moment on pick for Supreme Court MORE (Texas) called the threat posed by radical Islamic terrorism “real and growing” in his statement congratulating Trump on his victory.

GOP priorities that had seemed dead now have new life, such as construction of the Keystone XL pipeline, which Obama shelved.

Republicans also say the tide has turned in what they call Obama’s war on coal. McConnell noted Wednesday that many of the new regulations affecting the coal industry were passed unilaterally by the Obama administration and can be unraveled by Trump without congressional action.

Before kicking off the 115th Congress, however, congressional Republicans need to wrap up unfinished business in the lame-duck session scheduled for late November and December.

Lawmakers must figure out a way to fund the government beyond Dec. 9 either through a long-term continuing resolution that freezes spending levels or an omnibus package that sets new funding priorities. Another measure that is likely to pass is the 21st Century Cures Act, a bill funding innovative healthcare research.