Mayor de Blasio deprecated the Charging Bull sculpture in Lower Manhattan on Friday as a “celebration of unfettered capitalism” — while defending the Fearless Girl statue in front of the bull for “standing up to injustice.”

The mayor made the comment on his weekly WNYC radio show, where he also vowed that the city would fight a lawsuit by the creator of Charging Bull to get rid of Fearless Girl.

“I think the artist has to realize times change, people want to see things that represent their lives and their realities,” de Blasio said.

“Let’s be blunt! Charging Bull is a celebration of unfettered capitalism, and I don’t think for lot of people that says it all.

“You can say it is about the spirit of optimism sure, but it is a symbol of Wall Street, and Wall Street to say the least is a double-edge sword.”

Hizzoner was responding to artist Arturo Di Modica, who told reporters two days earlier that the placement of “Fearless Girl” staring down his work makes him “sick.”

He is planning to sue State Street Global Advisors, the mutual fund company that placed “Fearless Girl” in opposition to his work, for trademark and copyright infringement.

The 4-foot “Fearless Girl” — installed for International Woman’s Day — initially had a temporary permit to stand opposite the bull.

But de Blasio extended it another 11 months at the request of women’s groups.

De Blasio said it would be a “mistake” for the frail 76-year-old artist to sue and that the city “will fight him legally.”

“’Fearless Girl’ to so many people means standing up to injustice, the empowerment of women…,” he added. “We think what has been done is absolutely legally appropriate on the city’s part. We are going to defend ‘Fearless Girl’ and her right to be there.”

DiModica’s lawyer, Norman Siegel, told The Post that he and his client “respectfully and strongly disagree” with the mayor, adding his radio comments and similar recent tweets on the subject are “offensive and bully like.”

“We believe Arthur’s rights have been violated,” he added.

Siegel said his client hopes to resolve the issue “amicably” and had “hope[d] the mayor would play a positive role” in the discussion. However, he added that “now appears” to not be the case.

“We expected more from the mayor of New York City,” he said.