We're previewing the Week 1 NFL slate with score predictions for each game from our Nation reporters, what to watch for in fantasy, ESPN Football Power Index projections from Seth Walder and Hank Gargiulo, and much more.

Catch up on Week 1: Biggest injuries of the week ... Projecting the season from 1-32 ... The Super Bowl path for every team ... Bold predictions to kick off the season

Jump to a matchup: PIT-CLE | SF-MIN | CIN-IND | TEN-MIA | HOU-NE | TB-NO | JAX-NYG | BUF-BAL | KC-LAC | SEA-DEN | WSH-ARI | DAL-CAR | CHI-GB | NYJ-DET | LAR-OAK

Point spread: PIT -3.5 | Matchup quality: 50 (of 100)

Jeremy Fowler's pick: The Steelers have won 11 games in Cleveland with Ben Roethlisberger as their quarterback, and though the Browns should be much improved, a passing offense ranked 20th or worse each season since 2014 inherits a quarterback (Tyrod Taylor) who barely averages 200 yards per game. That's a good matchup for a Steelers defense that thrives off rushing defense and limiting big plays downfield, while the Pittsburgh offensive line will be eager to get James Conner going. Steelers 27, Browns 21

Ahead of the opening kickoff, ESPN Chalk has you covered with all your betting needs:

Pat McManamon's pick: An angry Steelers team is usually not a good thing for the Browns, who start with a new quarterback (Taylor), receiver (Jarvis Landry), running back (Carlos Hyde), left tackle (Joel Bitonio) and right tackle (Chris Hubbard), along with a new coordinator (Todd Haley) and new offensive system. It is not easy to bring that all together immediately. Steelers 24, Browns 17

FPI win projection: PIT, 65 percent. The FPI sees this as Cleveland's best chance at winning against the Steelers since Week 6 of the 2014 season, when Cleveland was a 56 percent home favorite. Every game since, the FPI has had Pittsburgh as at least a 72 percent favorite.

What to watch for in fantasy: Conner seems likely to start at running back for the Steelers. So what if you draft Le'Veon Bell in your league? Read more.

In case you missed it: All the possible Le'Veon Bell scenarios ... Gordon believes Browns' hope for his return is justified

Point spread: MIN -6.5 | Matchup quality: 59.4 (of 100)

Nick Wagoner's pick: Even before the injury to Jerick McKinnon and suspension for Reuben Foster, the 49ers figured to be facing an uphill battle against the Vikings. This week, coach Kyle Shanahan acknowledged that losing McKinnon was a serious blow to his game plan. The Niners have lost five consecutive road games to the Vikings. That streak continues. Vikings 27, 49ers 20

Courtney Cronin's pick: The Vikings usher in the Kirk Cousins era at home. Minnesota's No. 1 defense has allowed 10 points or fewer in five of its past seven regular-season games. Cousins and his playmakers have been working all offseason to build their on-field chemistry, which involves spreading the ball around and placing an emphasis on Dalvin Cook, Latavius Murray and this explosive backfield. Vikings 27, 49ers 13

FPI win projection: MIN, 70 percent. Jimmy G and the 49ers might have finished 2017 with a five-game winning streak, but a Week 1 trip to Minnesota and the FPI's top preseason defense is a big test.

What to watch for in fantasy: With McKinnon's injury, Alfred Morris has predictably been the most-added player in ESPN leagues the past week. Keep him on the bench in Week 1, though. Read more.

In case you missed it: How Kobe Bryant became 'essential' in Sherman's recovery ... Cousins' all-or-nothing pursuit kicks off against 49ers ... A perfect match? Garoppolo and the Bay Area's instant embrace

Point spread: IND -3 | Matchup quality: 38.2 (of 100)

Katherine Terrell's pick: The Bengals seemed quietly confident this week, and there's a reason for that. They have new offensive and defensive coordinators, a revamped offensive line and healthy weapons in Tyler Eifert and John Ross. The Colts don't appear to have much of a pass rush, and the Bengals' talented defensive line can take advantage of the fact that this will be Andrew Luck's first game since 2016. Bengals 24, Colts 17

Mike Wells' pick: The Colts have lost four consecutive Week 1 games, their starting left tackle just returned to practice for the first time in five weeks following a hamstring injury, and their starting running back just returned from a hamstring injury suffered Aug. 9. What the Colts do have going for them is that Luck is the healthiest he has been since Week 1 of the 2015 season. Colts 21, Bengals 17

FPI win projection: IND, 61 percent. With Luck back in the fold, the Colts are FPI favorites in nine games this season after being favored only once in 2017. The Bengals can up their odds to make the playoffs to nearly 30 percent with a victory, but a loss drops them below 15 percent.

What to watch for in fantasy: Here's why A.J. Green and Ross have an advantageous matchup against this Colts defense. Read more.

In case you missed it: Luck 'excited' ahead of regular-season return ... Willis could be more than run-stopper for Bengals

Point spread: TEN -1.5 | Matchup quality: 34.9 (of 100)

Turron Davenport's pick: New offensive coordinator Matt LaFleur hopes to take advantage of the Dolphins' linebackers with Dion Lewis and the tight end combo of Delanie Walker and Jonnu Smith. The Titans' secondary, bolstered by the addition of Malcolm Butler, will protect an early lead to give Mike Vrabel a victory in his first game as coach. Titans 24, Dolphins 17

Cameron Wolfe's pick: The Dolphins should use their up-tempo offense and South Florida humidity to wear out the banged-up Titans front seven, but none of that will save them if they can't score enough points. Tennessee's route to a win seems simple -- Lewis, Derrick Henry and Marcus Mariota exploiting the Dolphins' struggles to stop the run. Titans 20, Dolphins 16

FPI win projection: TEN, 50.4 percent. Tennessee is the most narrow FPI favorite of the week and could nudge its playoff probability just north of 50 percent with a win. Miami goes from Jay Cutler (43.5 Total QBR in 2017) back to Ryan Tannehill (48.6 in 2016), who missed last season because of injury.

What to watch for in fantasy: With Tannehill back, Kenny Stills could quickly emerge as a WR3. Read more.

In case you missed it: After 637 days, 'riled up' Tannehill returns for real ... Vrabel to Mariota: Let it rip! ... Gase confident Dolphins can reclaim 2016 magic

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Point spread: NE -6.5 | Matchup quality: 59.4 (of 100)

Sarah Barshop's pick: Houston certainly has the playmakers to win in New England -- especially with a healthy Deshaun Watson, J.J. Watt and Jadeveon Clowney -- but it's hard to pick against a Patriots team that has never lost to the Texans at Gillette Stadium. It will be a close game like last season, but the Texans will come up short again. Patriots 30, Texans 24

Mike Reiss' pick: Three of the Patriots' key starters -- Rex Burkhead, Marcus Cannon and Trey Flowers -- didn't play in the preseason, and the team enters the game with just three wide receivers who were with the club in training camp: Chris Hogan, Phillip Dorsett and Cordarrelle Patterson. Add in the fact that Jacob Hollister might not be ready, and it's asking a lot of the offense against the Texans' D. Texans 24, Patriots 20

FPI win projection: NE, 73 percent. All eyes will be on the quarterbacks. Watson led the league last season with an 93.5 Total QBR at the time of his injury in November. The ageless Tom Brady finished the season third in QBR, the fourth consecutive season he has finished in the top five.

What to watch for in fantasy: Matthew Berry says Lamar Miller is a top-10 fantasy back in 2018. Read more.

In case you missed it: As Brady improves movement, 'broken-play coach' helps Patriots ... Are Texans for real? Week 1 is an early litmus test ... Where does 2018 WR corps rank among those in Belichick's tenure?

Point spread: NO -9.5 | Matchup quality: 48.1 (of 100)

Jenna Laine's pick: The Bucs won't have the suspended Jameis Winston, and their new pieces on defense -- defensive linemen Beau Allen, Jason Pierre-Paul and Vinny Curry -- haven't had enough time to jell to effectively rattle Drew Brees. The Saints also boast what Ryan Fitzpatrick called one of the league's "best home-field advantages," even if they historically have struggled in September. Saints 29, Bucs 21

Mike Triplett's pick: Both teams will be missing star players because of suspensions. But the Saints' offense is still loaded without Mark Ingram. I'm surprised the betting line is flirting with double digits, even with Winston out. But this is practically a must-win game for a Saints team with Super Bowl aspirations. New Orleans can't afford another slow start after starting 0-2, 0-3, 0-3 and 0-2 the past four seasons. Saints 27, Bucs 19

FPI win projection: NO, 82 percent. The Saints get the good scheduling fortune of catching Tampa Bay without Winston. Had Winston been available, New Orleans would still be the favorite, but closer to 75 percent.

What to watch for in fantasy: Michael Thomas got at least eight targets in 14 of his 16 games last season, and Matthew Berry thinks he could be the top-scoring WR in fantasy in 2018. Read more.

In case you missed it: Beyond the brawl: Mike Evans-Marshon Lattimore is must-see TV ... Saints don't have time to waste another season with a slow start ... Only Saints RBs on active roster are Kamara, Gillislee

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Point spread: JAX -3 | Matchup quality: 46.8 (of 100)

Mike DiRocco's pick: The Jaguars are 0-3 all time at MetLife Stadium, but this is by far the best team they've brought to New Jersey. The marquee matchup is Jalen Ramsey vs. Odell Beckham Jr., but don't get sidetracked. The Jaguars' running game, with the addition of Andrew Norwell and a slimmed-down Leonard Fournette, will determine the outcome. Jaguars 25, Giants 16

Jordan Raanan's pick: The revamped Giants offense finally takes the field with Beckham and Saquon Barkley. That should help a unit that scored 13.6 points last season with Beckham either limited or out with injury; the Giants average 23 points with him at or near full strength. The Jaguars were the No. 2 scoring defense last season, and ranked second with 55 sacks. That's a problem for the new-look Giants offensive line, which still has problems on the right side. Jaguars 21, Giants 20

FPI win projection: NYG, 51 percent. Will a healthy OBJ, plus the addition of Barkley, be enough on offense for the Giants to overcome the most efficient defense from 2017? It might come down to whether they can protect 37-year-old quarterback Eli Manning.

What to watch for in fantasy: Should you start Beckham against Ramsey this week? Ramsey might not shadow him, but here's why OBJ should be downgraded. Read more.

In case you missed it: Inside Jalen vs. OBJ, from those who have faced them ... Ramsey is OBJ's toughest matchup yet ... How Bouye will factor into Jags' success vs. Giants

Point spread: BAL -7.5 | Matchup quality: 41.3 (of 100)

Mike Rodak's pick: Baltimore's defense allowed the NFL's 10th-fewest passing yards in 2017. The chances seem low of seeing new Bills offensive coordinator Brian Daboll, quarterback Nathan Peterman and an offensive line that struggled this preseason all click immediately in a road opener. Ravens 20, Bills 13

Jamison Hensley's pick: Since 2008, Baltimore is 5-1 when opening the season at home, with an average margin of victory of 17.2 points. To make matters worse for the Bills, the Ravens return every starter on defense, and their pass rush has been dominant this preseason. That spells a long day for Peterman. Ravens 20, Bills 6

FPI win projection: BAL, 84 percent. Baltimore is the FPI's biggest favorite of the week, partially because the Bills are starting Peterman, who finished last season with a 12.4 Total QBR in limited action.

What to watch for in fantasy: Fantasy's No. 7 running back from 2017 did not suddenly get too old to do it again -- Eric Karabell ranked LeSean McCoy as one of the top RB2 options this week. Read more.

In case you missed it: Starting Peterman not a surprise, despite '17 disaster ... Ravens' secret weapon? Jackson 'absolutely' ready to play