"We need to pick up four seats come November, and I think we're headed in that direction for sure," he told reporters during a press conference on Monday.

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Democrats are facing a favorable election map as they seek to win a 51-vote majority in the Senate. Republicans are defending 24 incumbents this year, including a handful from blue states won by President Obama during the 2012 elections.

Republicans now have a 54-46 majority in the Senate.

Reid said Democrats are looking "very good" in blue-leaning Wisconsin, Illinois, Ohio and Pennsylvania and "doing well" in Missouri, New Hampshire and Florida, saying the states represent "takeovers" for Democrats.

Former Nevada Attorney General Catherine Cortez Masto is running for the Democratic nomination.

Reid said that while Democrats "feel extremely comfortable" about the Nevada race, more work needs to be done.