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Antipsychotic drugs include: Seroquel (Quetiapine), Chlorpromazine, Haloperidol, Perphenazine, Fluphenazine, Risperidone, Olanzapine, Quetiapine, Ziprasidone, Aripiprazole, Paliperidone, and Lurasidone.

Also, antipsychotic medications (e.g., risperidone, olanzapine) should be available in the event that an adverse reaction escalates to unmanageable psychosis.

However, experienced clinicians have suggested that although antipsychotic medications may reduce psychotic behavior through sedation, [the use of antipsychotic medications] may be problematic because the effects may be abrupt, unpleasant, and intense and their use may result in subsequent psychological problems (McCabe, 1977; Grinspoon and Bakalar, 1979; Grof, 1980).

Furthermore, pretreatment with the antipsychotic haloperidol has been shown to exacerbate the psychosis-like effects of psilocybin (Vollenweider, et al., 1998), suggesting that haloperidol should not be used as a rescue medication.