Nov. 21, 2008 -- Another day, another 400-point market sell-off or dismal jobs report or tax-payer-funded corporate bailout. It goes without saying that we are living in uncertain times, and how you react to this uncertainty may say a lot about your mental health. In a newly published study, uncertainty was found to be far more stressful for highly neurotic people than dealing with a clearly negative outcome. The opposite was true for people with low scores for neuroticism. These people exhibited more stress when faced with negative feedback than uncertainty. "Objectively speaking, uncertainty is better than clearly negative information, but this is not true for people who are highly neurotic," University of Toronto doctoral candidate and study researcher Jacob Hirsh tells WebMD. "These people do not deal with uncertainty very well."

Uncertainty and the Brain The study, published in the journal Psychological Science, showed what is going on in the brain when we experience uncertainty. Hirsh and colleague Michael Inzlicht, PhD, conducted personality testing on 41 undergraduate students using a standardized test measuring five major personality traits, including neuroticism. They then used electroencephalography (EEG) to monitor brain activity. While the EEG was being conducted, the students were asked to perform a fairly simple task on a computer. The participants were then shown signs indicating positive feedback (a plus sign), negative feedback (a minus sign), or uncertain feedback (a question mark). All the students exhibited higher neural responses when they got negative feedback than when the feedback was positive. But neural activity was highest following uncertain feedback in the students with the highest scores for neuroticism. For students in the middle of the neuroticism spectrum, negative feedback and uncertain feedback elicited similar neural activity. "The idiom 'the devil you know is better than the devil you don't know' perfectly characterizes the attitudes of highly neurotic people," Hirsh says.