The hypothyroid drug levothyroxine (Synthroid, AbbVie) was the most prescribed drug in the United States, and the arthritis drug adalimumab (Humira, Abbott Laboratories) was the best-selling drug through March of this year, according to recent data.

Research firm IMS released a rolling 12-month history of prescription numbers and total sales from April 2014 through March 2015.

Levothyroxine had about 21.6 million prescriptions, followed by cholesterol-lowering drug rosuvastatin (Crestor, AstraZeneca), at about 21.5 million prescriptions; asthma medication albuterol (Ventolin HFA, GlaxoSmithKline), at about 18.2 million prescriptions; proton pump inhibitor esomeprazole (Nexium, AstraZeneca), at about 15.3 million prescriptions; and asthma medication fluticasone propionate/salmeterol (Advair Diskus, GlaxoSmithKline), at about 13.8 million prescriptions.

The remaining top 10 most prescribed drugs for the period (in order) were the insulin glargine injection (Lantus Solostar, sanofi-aventis), the attention-deficit drug lisdexamfetamine dimesylate (Vyvanse, Shire), the antiepileptic drug pregabalin (Lyrica, Pfizer), the chronic obstructive pulmonary disease medication tiotropium bromide (Spiriva Handihaler, Boehringer Ingelheim Pharmaceuticals), and the diabetes drug sitagliptin (Januvia, Merck)

Top Sellers

The arthritis drug adalimumab (Humira, Abbott Laboratories) had sales of about $8.3 billion, followed by the antipsychotic medication aripiprazole (Abilify, Otsuka Pharmaceutical) at $8 billion, the hepatitis C drug sofosbuvir (Sovaldi, Gilead Sciences) at $7 billion, the cholesterol-lowering drug rosuvastatin (Crestor, AstraZeneca) at $6 billion, and the arthritis drug etanercept (Enbrel, Amgen) at almost $6 billion.

The remaining top 10 drugs in sales were the hepatitis C drug ledipasvir/sofosbuvir (Harvoni, Gilead), the proton pump inhibitor esomeprazole (Nexium, AstraZeneca), the asthma medication fluticasone propionate/salmeterol (Advair Diskus, GlaxoSmithKline), the insulin glargine injection (Lantus Solostar, sanofi-aventis), and the arthritis drug infliximab (Remicade, Centocor).

Top 100 Prescriptions, Sales

Drug Name Sales Synthroid 21,561,481 Crestor 21,478,776 Ventolin HFA 18,203,939 Nexium 15,298,228 Advair Diskus 13,776,325 Lantus Solostar 10,939,840 Vyvanse 10,413,999 Lyrica 10,022,365 Spiriva Handihaler 9,635,935 Januvia 9,148,946 Lantus 9,145,153 Abilify 9,099,978 Symbicort 8,265,594 Tamiflu 8,025,275 Cialis 7,472,719 Viagra 7,104,074 Suboxone 6,985,631 Zetia 6,925,137 Xarelto 6,739,752 Bystolic 6,461,435 Celebrex 6,449,730 Nasonex 6,432,382 Namenda 5,961,360 Flovent HFA 5,736,650 Oxycontin 5,347,532 Diovan 5,224,025 Thyroid 5,128,576 Voltaren Gel 5,123,676 Nuvaring 4,917,514 Afluria 4,650,167 Dexilant 4,620,902 Benicar 4,483,555 Proventil HFA 4,385,623 Humalog 4,209,193 Novolog Flexpen 4,179,914 Novolog 3,968,615 Vesicare 3,686,182 Premarin 3,462,987 Benicar HCT 3,352,383 Lo Loestrin Fe 3,335,659 Lumigan 3,298,208 Namenda XR 3,157,234 Humalog Kwikpen 3,043,015 Janumet 3,027,293 Pataday 2,905,818 Ortho-Tri-Cy Lo 28 2,900,301 Travatan Z 2,861,717 Combivent Respimat 2,846,891 Toprol-XL 2,811,156 Pristiq 2,769,837 Invokana 2,711,901 Minastrin 24 Fe 2,555,803 Strattera 2,418,649 Seroquel XR 2,390,205 Vytorin 2,384,517 Focalin XR 2,334,004 Dulera 2,307,692 Levemir Flexpen 2,283,328 Zostavax 2,279,662 Avodart 2,271,799 Pradaxa 2,257,507 Chantix 2,208,377 Eliquis 2,179,340 Humira 2,173,082 Levemir Flextouch 2,164,191 Levemir 2,100,856 Victoza 3-Pak 2,078,630 Combigan 1,909,750 Exelon 1,825,705 Tradjenta 1,744,708 Premarin Vaginal 1,738,728 Enbrel 1,691,819 Onglyza 1,691,615 Ranexa 1,661,050 Truvada 1,651,083 Welchol 1,644,996 Linzess 1,639,652 Latuda 1,635,230 Alphagan P 1,483,322 Viibryd 1,425,156 Effient 1,406,934 Norvir 1,376,523 Amitiza 1,371,937 Azor 1,338,802 Advair HFA 1,310,993 Uloric 1,293,249 Lotemax 1,245,330 Myrbetriq 1,230,040 Asmanex Twisthaler 1,219,923 Epiduo 1,212,887 Xopenex HFA 1,204,025 Durezol 1,189,206 Patanol 1,181,134 Atripla 1,147,295 Aggrenox 1,144,739 Exforge 1,134,532 Humulin R 1,110,123 Carafate 1,110,008 Novolog Flxpen Mix 70/30 1,069,219 Relpax 1,035,265 Total 426,157,198

Top 100 Prescriptions, Dollars