“Blue Pill” was first previewed by Metro Boomin in December 2014 at Fader Fort/Converse Rubber Tracks in Brooklyn, New York. The song was archived until its release on September 17, 2017, where it was uploaded to Metro’s SoundCloud. Shortly before the song was added to iTunes, Metro updated the mix of the song on his SoundCloud.

Travis tweeted the artwork and mentioned Metro alongside the tweet on the night of its release, while Metro stated the song is a “late birthday gift.”

Engineer Alex Tumay (a frequent collaborator with both Metro and Travis) tweeted shortly following the release indicating that he was involved in the song’s creation, then explained to an inquiring fan that it was made in 2014/15, and further explained that he started working on this song the night Travis recorded “Maria, I’m Drunk.”