The trio of creators behind “Glee” are back together to produce a comedy-horror anthology series, “Scream Queens,” that has grabbed a straight-to-series order from Fox.

Project is designed to be an anthology series revolving around two female leads each season. The first season will revolve around activity at a college campus that is rocked by a series of murders. Fox has given a 15-episode order to the series created by Ryan Murphy, Brad Falchuk and Ian Brennan, who exec produce with another key member of the “Glee” team, Dante Di Loreto, for 20th Century Fox TV.

Fox Television Group chairman Gary Newman and Dana Walden said they had made it a priority to get a new series for Fox from Ryan Murphy after taking the reins of the network in July. “Scream Queens” is targeted to debut next fall.

“We loved every element of the pitch for this show – the genre-bending concept, which blends true horror with big comedic moments; the diverse and unforgettable characters and reuniting the phenomenal creative team that delivered ‘Glee,’ ” said Walden and Newman. “It’s a huge commitment and an expression of our faith in Ryan. We are ecstatic to have him, along with Brad, Ian and Dante as our partners on this exciting ride.”

“Scream Queens” takes a cue from the anthology format that Murphy and Falchuk have used with great success on FX’s “American Horror Story,” which relaunches each season with a mostly new cast of characters. Murphy said a casting search for a dozen key roles on “Scream Queens” has already begun.

“We hope to create a whole new genre – comedy-horror – and the idea is for every season to revolve around two female leads,” Murphy said. “We’re very grateful to Dana and Gary for their enthusiastic support.”

The work on “Scream Queen” comes as “Glee” heads into its sixth and final season on Fox early next year.

The order for “Scream Queens” ensures that Murphy’s 20th TV-based Ryan Murphy Television remains one of the busiest shops in TV. “Freak Show,” the fourth incarnation of “American Horror Story,” launched last week’s to FX’s highest ratings ever. Murphy landed a series order from FX earlier this month for the true-crime miniseries “The People Vs. O.J. Simpson,” envisioned as part of a new “American Crime Story” anthology. And Murphy is at work on a followup telepic at HBO to the Emmy-winning “The Normal Heart.”

(Pictured: Brad Falchuk, Ryan Murphy, Ian Brennan)