KABUL, Afghanistan — Underscoring the continued threat to civilians in Afghanistan, a drone strike in an eastern province killed up to 16 people, Afghan officials said Sunday, while a Taliban assault in another province killed four intelligence officers and wounded more than 120 civilians.

The drone strike occurred Saturday afternoon in the Watapur district of Kunar Province, a stronghold for the insurgency ensconced in hard-to-access mountainous terrain. Afghan officials said the drone was targeting four insurgents who were picked up along the road by a truck with civilians in it, though reports differed on the number of passengers. Women and children were among the dead, officials said.

“The insurgents often force local drivers to give them rides in their trucks,” said the Kunar police chief, Abdul Habib Saidkhail.

Coalition officials confirmed the strike, which they said had killed 10 insurgents. Officials said that they had no initial reports of civilian casualties, but that they would investigate.