Not wanting to burst your bubble, guys but, Propofol positive effects on PALS are more likely to be temporary, just like OSC was, which means new doses/injections will be needed once the effects start to wear off.



You are not going to see your...let's say dentist on monthly basis to get a tooth pulled every time so you can get exposed to a new dose of Propofol to keep the effects of the drug from wearing off.



Furthermore, only well trained people (nurses, surgeons) could run this procedure as Propofol affects breathing which is severely compromised on people with ALS.



Lastly, what about side effects resulting on prolonged/chronic use of this drug?



And, what about drug tolerance?



Drug tolerance which occurs when a person’s reaction to a drug decreases so they need larger and larger doses to have the same effect.

For example, if a person uses painkillers over an extended period of time, then they will need to consume larger and larger quantities in order to get the same results. Drug tolerance, in other words, is desensitization to a drug which might happen with Propofol.



What would happen once people (PALS, in this case) develop drug tolerance to it?

Get larger doses?



So many factors involved here before jumping the gun.





NH