ACURASYS study in NEJM, Sept 16th, 2010

issue'

So here I was starting my career in Critical Care- trying to achieve the gold standard as far as paralytic use (no use) went, when out came the – ‘. It was a multi center randomized trial involving 340 patients with severe ARDS (P/F < 150). The patients were randomized to 48 hours of paralytics + deep sedation vs deep sedation (same low tidal volume & PEEP settings were used in both arms). The trial showed a significantly lower mortality in patients who received paralytics (31% vs 40%).Patients in paralytic arm were also liberated early from ventilator and had less Pneumothorax.