Herm Edwards examines what the loss of Derek Carr to a broken fibula means for the Raiders and how the team can rebound from this. (1:55)

Here are the most significant NFL players who got banged up in Week 16:

Derek Carr, QB, Oakland Raiders: Carr broke his right fibula in the fourth quarter as his cleat got stuck in the ground while Colts OLB Trent Cole sacked him. He will have surgery Sunday and is out indefinitely. Carr, an MVP candidate, immediately grabbed his leg and stayed on the turf. It was only the second time all game the Colts pressured Carr behind one of the NFL's best offensive lines. Trainers helped him off the field, and Carr couldn't put weight on his right leg. They examined Carr on the sideline before carting him to the locker room. Matt McGloin replaced the QB in the lineup.

Marcus Mariota, QB, Tennessee Titans: Mariota had to be carted off the field in the third quarter after injuring his right leg. Coach Mike Mularkey said after the game that Mariota has a fractured fibula, adding, "Obviously, he is out." Matt Cassel replaced the second-year QB in the lineup as the Titans fell to the Jaguars.

Tyler Lockett, WR, Seattle Seahawks: Lockett made an incredible near-TD catch late in the second quarter, but he suffered a serious right leg injury on the play. A source told ESPN that Lockett's leg is broken and that he'll have surgery Sunday morning. His ankle got pinned under Cardinals CB Brandon Williams as he dove for the catch. The second-year WR was in visible pain as trainers put an air cast on his leg and carted him off the field.

Carlos Hyde, RB, San Francisco 49ers: Rams CB E.J. Gaines popped Hyde low as the running back caught a swing pass in the fourth quarter. Hyde fumbled on the play as he grabbed his left knee. The 49ers didn't take long to rule their star RB out with a knee injury. After the game, Hyde was optimistic that the injury wasn't too bad, but ESPN's Adam Schefter reported that the RB suffered a torn MCL and will miss the reminder of the season.

Cameron Brate, TE, Tampa Bay Buccaneers: Brate took a shot in his back midway through the third quarter. He walked off the field very slowly with the training staff. Brate, who scored a TD on Saturday, walked up and down the sideline very slowly with trainers, clutching his lower back. The team downgraded him from questionable to doubtful in the fourth quarter.

Thomas Rawls, RB, Seahawks: When the Seahawks came out of the locker room in the second half, they used rookie Alex Collins as the feature back. Eventually, the team announced a right shoulder injury for Rawls. It initially called him questionable before ruling him out. After the game, Carroll said Rawls had a bruised shoulder. He did not have a timetable for recovery.

Robert Griffin III, QB, Cleveland Browns: Griffin took a high hit from linebacker Korey Toomer as he was being tackled by Darius Philon in the fourth quarter. Griffin returned to the huddle, but it appeared officials signaled for Browns trainers to come check on the QB. Griffin went to the locker room for further evaluation, where trainers diagnosed him with a concussion. Rookie Cody Kessler replaced RG III behind center.

Bryce Petty, QB, New York Jets: Petty stayed on the ground for a little while after making a tackle after a Malcolm Butler fumble recovery. Trainers examined his left shoulder (nonthrowing) on the sideline before taking him to the locker room. The team ruled him out for the game in the third quarter; QB Ryan Fitzpatrick replaced Petty in the lineup. The second-year QB had his arm in a sling after the game and said he "felt something pop."

Jay Ajayi, RB, Miami Dolphins: Ajayi, who had 206 yards rushing on Saturday, was favoring his left shoulder late in the Dolphins' OT victory over the Bills, but he never left the field for an extended period of time. After the game, he said his shoulder felt fine, adding that it might be an AC joint issue. Ajayi did say he will be ready for next week.

Donte Moncrief, WR, Indianapolis Colts: Moncrief's frustrating injury season continued on Saturday, as he left the Colts' game against the Raiders in the fourth quarter with a shoulder injury. He did not return to the game.

Bryan Bulaga, RT, Green Bay Packers: Bulaga pulled himself out of the game in the second half, and trainers examined his right shoulder/arm on the sideline. He did not return to the field, as the Packers had the game in hand.

DeSean Jackson, WR, Washington Redskins: Jackson injured his jaw late in the third quarter, and the Redskins WR did not return to the field after being listed as questionable.

Darius Butler, CB, Indianapolis Colts: Butler tried to lay a big hit on Raiders RB Jalen Richard in the second quarter, but he suffered a concussion on the play and was ruled out for the remainder of the game.

Leonard Floyd, OLB, Chicago Bears: Floyd left the game in the second quarter to be evaluated for a concussion and was eventually ruled out. It's the second head-injury scare of the season for Floyd, who was carted off the field against the Jets on Nov. 20. He sustained a concussion on that play and missed one game.

Kenny Britt, WR, Los Angeles Rams: Britt was on the injury report this week due to his shoulder, and he reaggravated the injury on Saturday against the 49ers. The team ruled him out for the game in the third quarter.

T.J. Yeldon and Chris Ivory, RBs, Jacksonville Jaguars: Yeldon tweaked his ankle on his second carry of the game. At first, the Jaguars were optimistic about his return, listing him as probable, but they downgraded him to questionable later in the first quarter before ruling him out after halftime. Ivory saw his workload increase with Yeldon out, but he got hurt in the second half, too (hamstring), and did not return.

Joe Haden, CB, Cleveland Browns: Haden was taken to the locker room in the second half with a neck injury. It was not immediately clear how the injury occurred, but the team ruled him out in the fourth quarter.

LaDarius Gunter, CB, Green Bay Packers: Gunter hurt his elbow in the first half and was eventually ruled out for the game. That means Damarious Randall, who was benched last week, will remain in the mix at cornerback with Gunter out.

Matt Slauson, G, San Diego Chargers: Slauson left the game in the second quarter with a foot injury and was listed as questionable to return. The Chargers also lost two other offensive linemen for some period of time in the first half -- Orlando Franklin and Joe Barksdale.

Deon Bush, S, Bears: Bush left the game in the first half with an ankle injury. He was initially listed as questionable before being downgraded to out. The Bears also lost Tracy Porter with a shoulder injury in the second half. He was listed as questionable.

Kam Chancellor, S, Seahawks: Chancellor suffered an ankle injury in the second quarter, and the team listed its star safety as questionable. Chancellor tried to test his ankle out on the sideline before heading to the locker room with about four minutes left in the second quarter. He returned to the field in the second half, which is good news for a Seahawks team already playing without All-Pro safety Earl Thomas, who is out for the year with a fractured tibia.

Robert Kelley, RB, Washington Redskins: Kelley took a high-low hit in the second quarter and stayed down on the ground afterward, grabbing his right knee. Kelley looked to be in a lot of pain, but he returned to the field in the third quarter.

Pernell McPhee, OLB, Bears: Trainers examined McPhee's shoulder after the linebacker failed to bring down Kirk Cousins on a 9-yard scramble TD. The team listed McPhee as questionable, but he returned to the field in the third quarter.

Keanu Neal, S, Atlanta Falcons: Neal left the game in the second quarter after a weird collision with Panthers WR Kelvin Benjamin. The Falcons officially called it an ankle injury and ruled him as questionable. The rookie didn't miss much time before returning to the field.