Britain has seen a night of horror with five stabbing attacks in just a few hours leaving two pepole dead and several injured in cities across the country.

A 21-year-old was killed after a brawl in Manchester that also saw two women knocked out.

In east London, a murder investigation has been launched after a 21-year-old man was stabbed to death.

Britain has seen a night of horror with five stabbing attacks in just a few hours leaving two pepole dead and several injured in cities across the country

In Sheffield, five people have been stabbed in two connected incidents in the city centre.

And in Birmingham, a 14-year-old boy is fighting for his life in hospital after being stabbed outside a mosque in the early hours of the morning.

Man, 21, dies after being stabbed in the neck during savage nightclub brawl that left two women knocked out and several clubbers and police injured

ByHarvey Day For Mailonline

A man has died after being stabbed in the neck during a savage nightclub brawl that left several clubbers and police injured.

Police are appealing for witnesses after the man was fatally stabbed during a large fight near Deansgate in Manchester city centre.

At around 2.50am cops were called to reports of a large fight involving men and women on John Dalton Street in the city centre.

A man has died after being stabbed in the neck during a savage nightclub brawl that left several clubbers and police injured

It is believed the fighting began in the Suburbia nightclub. Police officers were also attacked when they arrived and two cops were treated for minor injuries.

Officers attended and quickly identified that during the fighting a man had been stabbed.

A 21-year-old man was treated for stab wounds to his neck at the scene but he sadly died as a result of his injuries.

Several other people were taken to hospital with injuries, including a man who had been hit with a glass and two women, aged 19 and 21 who were left unconscious after being punched.

Police are appealing for witnesses after the man was fatally stabbed during a large fight near Deansgate in Manchester city centre

Police officers were also attacked during the fighting and two officers had to be treated for minor injuries

Police officers were also attacked during the fighting and two officers had to be treated for minor injuries.

Four men have been arrested by police including a 21-year-old man arrested on suspicion of a section 18 assault; a 24-year-old man arrested on suspicion of assaulting a police officer; a 19-year-old arrested on suspicion of violent disorder and possession of a knife; and a 19-year-old man arrested on suspicion of violent disorder.

All four men have been bailed after they were taken into police custody for questioning.

All four men are now in police custody for questioning. John Dalton Street and King Street South are currently closed

At around 2.50am police were called to reports of a large fight involving men and women on John Dalton Street in the city centre

Chief Superintendent Emily Higham from GMP's major incident team said: 'What we were faced with during the early hours of this morning was a large group of men and women fighting in the street.

'Sadly, a 21-year-old man has lost his life, my thoughts go out to his family at this unimaginably painful time.

'We are appealing for anyone who witnessed the fighting to get in touch as soon as possible. We believe the fighting started in the Suburbia nightclub and spilled out onto the road, so there is potentially a nightclub full of witnesses who we want to hear from.

This morning, Dave Wood wrote on Facebook: ' Everybody try and stay away from Deansgate. Tents all over the place. I have been told body bags as well looks well bad'

Chief Superintendent Emily Higham from GMP's major incident team said: 'What we were faced with during the early hours of this morning was a large group of men and women fighting in the street'

She added: 'Sadly, a 21-year-old man has lost his life, my thoughts go out to his family at this unimaginably painful time'

'There is currently a scene in place and some road closures in the area.

'I am asking anyone who has any information or concerns to get in touch with police as a matter of urgency. The level of violence people were using towards each other and police was shocking and this resulted in the tragic loss of a young man's life. We cannot let those responsible get away with this.'

This morning, Dave Wood wrote on Facebook: 'Everybody try and stay away from Deansgate. Tents all over the place. I have been told body bags as well looks well bad.'

Murder investigation after 21-year-old man was stabbed to death in East London

By Keiran Southern For Mailonline

A murder investigation has been launched after a 21-year-old man was stabbed to death.

Metropolitan Police officers were called to reports of a disturbance in Ropery Street in Bow, east London, at around 2.30am on Saturday.

They found the victim with stab wounds in nearby Eric Street.

A murder investigation has been launched after a 21-year-old man was stabbed to death in Bow, east London

Clothing and discarded medical equipment was pictured littering the street. Police were called to reports of a disturbance in Ropery Street at around 2.30am on Saturday

The victim, a 21-year-old man, was later found with stab wounds in nearby Eric Street

He was treated at the scene by paramedics from London's Air Ambulance service before being taken to a hospital, where he died at 4.52am.

Scotland Yard said detectives from the Homicide and Major Crime Command are investigating and no arrests have been made.

The victim's next of kin have been told but formal identification has yet to take place.

A post-mortem examination is also to be arranged.

The victim was treated at the scene by paramedics from London's Air Ambulance service before being taken to a hospital, where he died at 4.52am

Scotland Yard said detectives are investigating and no arrests have been made. Blood-soaked clothes and a mobile phone were pictured at the scene on Saturday morning

The victim's next of kin have been told but formal identification has yet to take place

Five people are stabbed in two linked late-night incidents in Sheffield city centre

By Iain Burns For Mailonline

Five people have been stabbed in two connected incidents in Sheffield city centre.

The area in which the stabbing happened in the early hours of the morning were cordoned off, while other streets remain on lockdown as police investigate.

Four people have been arrested, according to police.

Police tweeted that Cambridge Street, Carver Street/Division Street, Barker's Pool and Bethell Walk leading to Backfields were all closed 'until further notice'

Forensics offices were quick to the scene, where they investigated pools of blood and what appear to be beer barrels

Police tweeted that Cambridge Street, Carver Street/Division Street, Barker's Pool and Bethell Walk leading to Backfields were all closed 'until further notice'.

South Yorkshire Police said: 'We are dealing with two linked stabbing incidents in Sheffield City centre in the early hours of Saturday. Five people were injured.

'Four people have been arrested and detained in relation to the stabbing.'

The police later tweeted: 'The person who was critically injured in Sheffield early this morning is now in a serious but stable condition in hospital.'

Forensics officers were seen in the area investigating pools of blood and what appeared to be beer barrels.

The area has been put on lockdown after the shocking incident

South Yorkshire Police said : 'We are dealing with two linked stabbing incidents in Sheffield City centre in the early hours of Saturday. Five people were injured'

Man, 29, is arrested after teenage boy was stabbed outside mosque in front of his horrified brother just moments after being dropped off by his father for Muslim festival

By LARA KEAY FOR MAILONLINE

A 14-year-old boy is fighting for his life in hospital after being stabbed outside a mosque in the early hours of the morning.

The teen was attacked outside the Idara Maarif-e-Islam Hussainia Mosque on Herbert Road, in Small Heath, Birmingham, at around 1am today.

He was left with several stab wounds and was taken to hospital by paramedics after suffering life-threatening injuries. He remains in a critical condition and is believed to be from the Kings Heath area of Birmingham.

A 14-year-old boy is fighting for his life in hospital after being stabbed outside a mosque in the early hours of the morning

Police confirmed a 29-year-old man has been arrested on suspicion of attempted murder and is currently in custody.

A cordon is in place on the road while specialist teams carry out forensic investigations at the scene, which is near to Birmingham City FC's St Andrews stadium.

West Midlands Police has confirmed the incident is not terror related and is being treated as an attempted murder.

Witnesses at the scene told the Birmingham Mail the teenager was stabbed after being dropped off at the mosque by his father for a special youth event.

The teen was attacked outside the Idara Maarif-e-Islam Hussainia Mosque on Herbert Road, in Small Heath, Birmingham, at around 1am today

The venue was busy with people despite the late hour as worshippers celebrated the start of the Islamic Holy Year and the victim's brother 'saw it all'

One witness told the newspaper: 'His brother saw it all and was screaming to his dad to come and help.'

Azhar Kiana told the newspaper: 'It happened on the pavement.

'By the time, the dad parked his car, his son was on the floor.

'There was a young man who was brutally beating the boy with a knife.

'There was blood everywhere, he was hitting the boy's neck and head. Then the attacker ran off and got into a car.'

Adnan Khan, a senior member of the mosque's congregation said he believes it was a racist attack.

The information secretary said: 'We believe this was a racist attack and the young lad was in the wrong place at the wrong time.

'We had been advised about security and now have knife scanners at the entrance to the halls, but obviously nothing in the street.

He was left with several stab wounds and was taken to hospital by paramedics after suffering life-threatening injuries

'We believe they were lying in wait for someone to attack.'

Detective Inspector Jim Colclough from the complex crime investigation team at Bournville Lane police station said: 'Our investigation is progressing quickly but it is still in the early stages.

'We do not believe it to be terror-related. The motivation for the attack is not yet known, we are keeping an open mind as to whether it could be racially or religiously motivated.

'We are working closely with local communities and have increased our local police presence in the area to provide reassurance and be on hand to answer any questions or concerns that people may have.

'It is tragic event which has left a young boy in hospital fighting for his life.

'We've spoken to a number of witnesses but would continue to urge anyone who was in the area and saw what happened, or has any other information which may help our investigation to contact me or my team on 101 or to call Crimestoppers as soon as possible.'