Honestly, Medicine's the most dangerous one here.



It's day, so Rumia and Wriggle are out of their element.



Yuuka is insanely powerful, but she's pretty docile as long as you're polite and respectful to both her and the flowers. And it's beneath her to attack unprovoked, as with most elder youkai.



Medicine herself isn't aggressive, but her animosity toward humans and her presence implies a poisonous atmosphere both literally and figuratively, so it'd be best to hold your breath and move along.