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What is the context of this research?

Current fake drug detection platforms are reasonably portable, but expensive. They can have high drug specificity or sensitivity, but not both. We are designing a synthetic biological compound that could rapidly achieve both in a simple assay. By binding with artemisinin, our synthetic protein will change conformation, revealing a hidden reporter motif. In addition, our “Medicoli" detector can be rapidly adapted to detect biological and chemical warfare agents, producing results within minutes with minimal modification and at a low cost. This technology has the potential to bypass bureaucratic red tape, giving consumers the power to test their own medications in real time and save countless lives throughout the world.



What is the significance of this project?

The Medicoli detector is a versatile bio-detection platform that will be able to rapidly test for new drugs. Current counterfeit detection involves two different tests being conducted simultaneously in order to achieve both a high specificity and sensitivity. Medicoli is a simple tool to use, requiring only a single test to achieve both, and it does not require a lab or expensive equipment. Its essential benefit is flexibility which, depending on the specific protein-target binding efficiency, can assist in detection of many other compounds with minimal cost and sample size. This includes biomarkers for cancer and other diseases. The intellectual properties of manufacturers will also be protected, as fake drugs are removed from the market by this efficient detection system.





What are the goals of the project?

Our goal is to develop and test this potentially lifesaving platform with artemisinin. From there, we plan to expand to different medicinal compounds, and possibly to disease biomarkers. Our specific aims are to discover and characterize the binding sites of artemisinin to several different proteins. We will use that data to construct a synthetic detector protein that binds to artemisinin strongly and specifically. This protein will be designed such that the binding of artemisinin will expose a reporter motif, allowing for rapid and quantifiable detection. The detector will then be added to a biological system to rapidly produce a high concentration in solution, and the sensitivity and specificity will be tested by the addition of artemisinin and related compounds.