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Former "Entourage" star Jeremy Piven has an answer to the biggest sports question currently dogging his native city of Chicago ...

Is it time to finally give up on former MVP Derrick Rose?

Rose hasn't been the same since he won the award a few years ago ... and after all the injuries, legal issues and subpar play, some are wondering if it's high time to move on.

We got Piven -- a die hard Chicago sports fan -- doing some shopping out in L.A. and laid the question out to him ... his answer is sure to make the entire Rose family breathe a sigh of relief.