Australia has claimed silver in the women's 4x100 metres medley relay, while the men's team took bronze in the event.

The women's team of Emily Seebohm, Taylor McKeown, Emma McKeon and Cate Campbell finished in a time of 3.55.00, behind the United States.

Campbell, who took Australia from fifth to second place in the last 100 metres, told the ABC while there was "no denying" it had been a "tough week", she was proud of her final swim in Rio.

"I executed it exactly how I was supposed to do it two nights ago [in the 50m freestyle] and came away with a very different result and I can't be any prouder than that," she told the ABC.

"I'm really proud of the other three girls they really fought their hearts out and within that relay team there were some real highs and some real lows, but we all managed to pull it together when it counted."

Although she did not win an individual medal in Rio, Campbell said she executed the 50m freestyle race on Friday well and "can't be too hard" on herself with the result.

Australians celebrate their silver medal in the women's 4x100m medley relay. ( AP: Michael Sohn )

McKeon added another medal to her tally to take home a total of four.

"It is amazing ... I was hoping to make the podium but never really imagined it would happen," she told Channel 7.

Seebohm, who like Campbell had disappointing results earlier in the individual events, said it was a good way to end the meet.

"I knew, after my 100, I definitely have trained a lot harder than it showed in my 100," she told the ABC.

"I was happy I could finish the meet with almost my fastest time so far here.

"Physically I knew I could do it and mentally I thought I had it too. I guess when it didn't come together in the 100, it was OK, I could deal with that, but then the [200] was just almost too much and I really broke down."

The men's medley relay team took bronze behind the US and Great Britain. ( Reuters: Stefan Wermuth )

The men's team of Mitch Larkin, Jake Packard, David Morgan and Kyle Chalmers took bronze in 3.29.93, behind the US, which won gold with 3.27.95, and Great Britain.

"I can't believe it ... it definitely has me motivated moving forward," 18-year-old Chalmers, who won the 100m freestyle, told Channel 7.

The race also gave Michael Phelps, who swam the butterfly leg, his 23rd gold medal in his final Olympic race.

Larkin said it was always going to be hard to take on the US team.

"America is amazing, they have four really good swimmers," he said.

"Each of them picked up individual medals.

"It is really tough to beat a team like that."