Adelaide ruckman Reilly O’Brien is set to play his first AFL game since 2016 this Thursday night when the Crows face the Cats at Adelaide Oval.

Speaking to media on Wednesday, coach Don Pyke said the 23-year-old would replace injured big man Sam Jacobs who sustained a knee injury in Round Two.

INJURY UPDATE: Sam Jacobs to miss Round Three

O’Brien impressed in the Crows SANFL side’s first outing of 2019 on Saturday, collecting 17 disposals, 21 hit-outs, eight marks and five tackles.

He comes into the senior side on the back of a strong pre-season that saw him finish top three in both of Adelaide’s time trials.

Adelaide's full side will be announced on Wednesday at 5.50pm ACDT.