The Coffs Coast has the unenviable title of being the meth lab capital of the state.

Since the start of this year there have been busts at a South Coffs Harbour caravan park, a property near Sawtell and the latest at Grafton yesterday.

Coffs-Clarence acting crime manager Suzanne Rode-Sanders said a man and a woman have been charged over yesterday's raid.

"We yesterday executed a search warrant at an address in Federation Street at Grafton and found an active lab," she said.

"Our Chemical Ops people are here this morning processing the scene.

"The materials, the chemicals they use are quite volatile and also carcinogenic so there's a lot of precautions around processing the scene."

Detective Rode-Sanders said because the chemicals used to make the drug are so dangerous people are asked to report any suspicious activity.

"Any chemical smells that could indicate that there's a cook-up going on," she said.

"If they're selling from the premises, people quickly coming and going for short periods of time.

"Anything suspicious that they detect report it to police immediately.

"It's completely anonymous, we never divulge where our information's come from."