Rosie O'Donnell and Donald Trump have been feuding for the past 10 years, with the latest salvo taking place on Wednesday, when the lesbian comedian launched a profanity-laden slam on the Republican presidential candidate by stating: “I'm depressed because I f**ing hate that orange piece of s**t.”

As usual, the 54-year-old celebrity confused vulgarity with comedy, stating she'd rather “give birth to a flaming iguana while taking a s**t” than have contact with Trump. “I hate him. I hate him," she exclaimed while most of the crowd at a concert in New York City featuring '80s pop singers Boy George and Cyndi Lauper cheered her on.

According to an article by Paul Bois at the Truth Revolt website, someone in the audience referred to famous radio shock jock Howard Stern, prompting O'Donnell to say: “He is friends with the s**t stain, which worries me.”

She then went further, referring to the GOP candidate “a s**t stain with a tinge of orange.”

Kelly Mclaughlin of the Daily Mail website spoke with several people in attendance and found some of them had a different response to O'Donnell's anti-Trump tirade.

A man in the audience told Mclaughlin that he quickly pulled out his camera "to document the foul-mouthed rant.”

“Rosie's routine was just jaw-dropping," the man stated. “She sounds like she is obsessed with Donald Trump, and it was what she spent most of her very short act talking about.”

“Not everyone was impressed,” he added. “People around me were shaking their heads in disagreement.”

“One man near me turned to his wife and said: 'I really hope Donald gets elected so she keeps her promise and moves to Canada.' Another lady was shouting 'Get off and let Cyndi sing.'”

O'Donnell and Trump have been feuding since 2006, when he called her a “loser” after she questioned his decision not to fire then-Miss USA Tara Conner over her reported drug use.

The conflict erupted again in 2011, when O'Donnell announced she was engaged to marry her now ex-wife Michelle Rounds.

At the time, Trump tweeted: “I feel sorry for Rosie 's new partner in love whose parents are devastated at the thought of their daughter being with @Rosie -- a true loser.”

She responded on Twitter by calling him a “real a**.”

Then, after O'Donnell's heart attack in August of 2012, Trump tweeted to O'Donnell, saying he was thinking about her and hoped she got better, to which O'Donnell replied: “well thank u donald - i must admit ur post was a bit of a shock ... r u trying to kill me ? Xx”

As NewsBusters previously reported, O'Donnell became one of three new hosts for ABC's The View program in 2014, which had no conservative voice for its 18th season.

After learning of O'Donnell's return to the weekday program, Trump posted on Twitter: “Rosie is crude, rude, obnoxious and dumb -- other than that, I like her very much!”

While a panelist on the ABC series, the comedian made several interesting comments, including declaring Jimmy Carter “my favorite president ever” and “probably the most pious human being I've ever met in my life.”

O'Donnell later stated that the Brian Williams scandal is an example of why Americans should know that "what you hear on the news is not always the truth."

While discussing Williams' false claim to have been fired on by an RPG (a rocket-propelled grenade), the host attacked: "I think his credibility is being called into question, not only this instance, but over a series of exaggerations and/or lies or whatever you want to call it.”

Just six months after re-joining The View, O'Donnell announced in February of 2015 that she was again quitting the program – and splitting from her second “wife,” Michelle Rounds, so she “could spend more time with her children," a common excuse used by celebrities when they want to leave a project.

During the first Republican presidential debate held this past August, some of Trump's disparaging comments about women came back to haunt him when Fox News Channel host Megyn Kelly brought up Trump's use of the words “fat pigs.” “dogs”, “slobs” and “disgusting animals” when describing women.

"Only Rosie O'Donnell," Trump joked in response.

O'Donnell tweeted later that night: “try explaining that 2 ur kids.”

Since Trump recently accumulated enough delegates to secure the presidential nomination at the Republican convention in mid-July, it looks like O'Donnell will be very busy for the next few months at least.

Who knows what the foul-mouthed lesbian will do if Trump wins the race for the White House? Will she still be spending more time with her children then?