The Hand of God (神の一手, Kami no Itte), also known as the Divine Move, refers to the perfect game of Go. It is Fujiwara-no-Sai's goal to attain the Hand of God, and he credits his desire for it as why his spirit remains on earth. Koyo Toya, Akira Toya, and Hikaru Shindou also aim for the Hand of God.

Although throughout the series it was implied that the Hand of God could be attained by just one person, Kuwabara Hon'inbou speculates that the Hand of God, referring just to a perfect game, takes two people to attain, as it takes two people to play Go. He hints that Hikaru Shindou and Akira Toya will likely be the ones to attain the Hand of God through their games with each other.