The Anti-Christ is a leader who fulfills Biblical prophecies concerning an adversary of Jesus Christ. In "Rapture's Delight", he appears literally as the exact opposite of Jesus, twisting his words and skills. Effeminate and a little daft, he is still a dangerous foe and causes the death of Stan and was then killed by Jesus. He appears to be modeled after The Riddler of the Batman comic series.

Hayley and Jeff Fischer's adopted son Nemo turns out to be a young Anti-Christ in "Season's Beatings".

He is voiced by writer Murray Miller.