A top official at the Chamber of Commerce, the group that's a reliable supporter of the GOP and its candidates, is calling on Donald Trump Donald John TrumpOmar fires back at Trump over rally remarks: 'This is my country' Pelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Trump mocks Biden appearance, mask use ahead of first debate MORE to resign and cede the nomination to Mike Pence Michael (Mike) Richard PenceButtigieg stands in as Pence for Harris's debate practice Trump argues full Supreme Court needed to settle potential election disputes Pence adviser knocks ex-staffer who criticized Trump on COVID-19 MORE in light of his lewd comments leaked Friday.

"There is no GOP nominee for President in 2016. Fundamentally offensive & unqualified," Rob Engstrom, the national political director and senior vice president at the Chamber, tweeted late Friday night.

"Trump should step down immediately tonight, yielding to Governor Pence as the GOP Nominee."

Trump should step down immediately tonight, yielding to Governor Pence as the GOP Nominee. — Rob Engstrom (@RobEngstrom) October 8, 2016

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Republicans have broadly condemned Trump since the release of 2005 audio from a hot mic while appearing on NBC's "Access Hollywood."

During the audio, released by The Washington Post, Trump said that women let you "do anything" if you are "a star." He goes on to talk about trying to seduce a married woman and speaks lewdly about pursuing other women.

"You know I'm automatically attracted to beautiful — I just start kissing them. It's like a magnet. Just kiss. I don't even wait. And when you're a star they let you do it. You can do anything," he said in the audio. "Grab them by the p----,” Trump says. "You can do anything."

If Trump was to step down, the RNC would choose his replacement with a meeting of the 168 committee-members, three from each state and territory.