The NFL can be a brutal place. Players often get hurt, sometimes before the season even starts. Let’s take a look back at 10 of the most crushing preseason injuries of the last 25 years.

10. Jeremy Maclin, 2013

At a training camp practice in July 2013, then-Eagles receiver Jeremy Maclin tore his right ACL. Maclin missed all of the ensuing season but came back strong in 2014. That year, he caught 85 passes for a career-high 1,318 yards and 10 touchdowns.

9. Ki-Jana Carter, 1995

Early in his first career preseason game, Bengals running back Ki-Jana Carter draft tore his left ACL. The first overall pick of the 1995 draft had to put his rookie year on hold until 1996.