Cosmetic ingredients previously considered “inert” have potential to provide a biologic effect to skin. In a cosmeceutical formulation, the boundary between an “active” and “inert” ingredient may be obscured. For this reason, the cosmeceutical distributor must find a nonambiguous method to demonstrate the efficacy of a new ingredient. For a product to be successful in the marketplace, the benefits of the product must clearly be communicated to the consumer, and the consumer must be satisfied with product performance.