The widely used vitamin C and E supplements may blunt the improvement of muscular endurance by disrupting cellular adaptions in exercised muscles, a new study has warned.

As vitamin C and E supplements are widely used, understanding if they interfere with cellular and physiological adaptations to exercise is of interest to people exercising for health purposes as well as to athletes.

"Our results show that vitamin C and E supplements blunted the endurance training-induced increase of mitochondrial proteins, which are needed to improve muscular endurance," Dr Goran Paulsen, who led the study at the Norwegian School of Sport Sciences, said.

In the 11-week trial, 54 young, healthy men and women were randomly allocated to receive either 1000mg vitamin C and 235mg vitamin E (consistent with amounts found in shop supplements), or a placebo (a pill containing no active ingredients).

Neither the subjects nor the investigators knew which participant received the vitamins or placebos.

The participants completed an endurance training programme, consisting of three to four sessions per week, of primarily running. Fitness tests, blood samples and muscle biopsies were taken before and after the intervention.

Whilst the supplements did not affect maximal oxygen uptake or the results of a 20 metre shuttle test, the results showed that markers for the production of new muscle mitochondria - the power supply for cells - increased only in the group without supplements.

"Our results indicate that high dosages of vitamin C and E - as commonly found in supplements - should be used with caution, especially if you are undertaking endurance training," Paulsen said.

A significant trend has been identified, but the molecular processes requires further research.

"Future studies are needed to determine the underlying mechanisms of these results, but we assume that the vitamins interfered with cellular signalling and blunted expression of certain genes," Paulsen said.

The study was published in The Journal of Physiology.