Bengals at Bills, 1 p.m., CBS

Line: Bills -6 | Total: 44

The Zac Taylor experience in Cincinnati has led to the Bengals (0-2) piling up an enormous number of passing yards while struggling to turn those yards into points. They lost a close game in Week 1, then were crushed in Week 2, and while Andy Dalton most likely enjoys averaging 364.5 passing yards a game, he’d probably like to win a game at some point. That will be hard in Buffalo against the upstart Bills (2-0). If Bills running back Devin Singletary is forced to miss the game with a hamstring injury, this game gets far more competitive. Pick: Bengals +6

Steelers at 49ers, 4:25 p.m., CBS

Line: 49ers -6.5 | Total: 44

Winning consecutive road games to start the season was big, even if the wins came against Tampa Bay and Cincinnati. Suddenly the 49ers (2-0) are in line for what could be a huge bounce-back season — the rebuilt defense and a (mostly) healthy offense make the start more than just a mirage. San Francisco is back home, and will face the Steelers (0-2), a team off to a bad start that could get worse after the season-ending injury to Ben Roethlisberger. Backup quarterbacks have mostly been keeping teams respectable, but this may be an easy win for the 49ers. Pick: 49ers -6.5

Falcons at Colts, 1 p.m., CBS

Line: Colts -1.5 | Total: 47

The Colts (1-1) were good last year, even beyond the stellar play of Andrew Luck, a fact that has been underscored by their competitive performances with Jacoby Brissett under center. From Darius Leonard controlling the field on defense to Marlon Mack and Jordan Wilkins finding huge holes to run behind Quenton Nelson on offense, the only real flaw for Indianapolis this season has been the disappointing play of Adam Vinatieri, the veteran kicker. The Falcons (1-1) are coming off a win, and there is a major wild card in the fact that Leonard is in the concussion protocol and may not play. The Colts should be favored at home, but without Leonard their advantage is significantly diminished. Pick: Colts -1.5

Panthers at Cardinals, 4:05 p.m., Fox

Line: Even | Total: Off

The Panthers (0-2) are a mystery. Cam Newton is working his way through a foot injury and has not been practicing. That could lead the team to start Kyle Allen, a 23-year-old in his second season as a backup in Carolina after a disappointing college career split between Texas A&M and Houston. Truth be told, Carolina hasn’t been very good even with Newton, so this was looking like a difficult game no matter what. Kyler Murray, meanwhile, was terrible for the first three quarters of his first N.F.L. game, but has been loads of fun since. The Cardinals (0-1-1) are still developing as a team, and are likely to hit some rough patches, but this week gives Murray a solid opportunity for his first N.F.L. win. Pick: Cardinals