Sen. Susan Collins Susan Margaret CollinsThe Hill's Campaign Report: Biden asks if public can trust vaccine from Trump ahead of Election Day | Oklahoma health officials raised red flags before Trump rally Gideon leads Collins by 12 points in Maine Senate race: poll Senate leaders quash talk of rank-and-file COVID-19 deal MORE (R-Maine) will vote against confirming President Trump’s nominee to lead the Environmental Protection Agency (EPA).

Collins is the only Senate Republican to come out against Scott Pruitt, the Oklahoma attorney general who sued the EPA 14 times during former President Obama’s administration.

“I have significant concerns that Mr. Pruitt has actively opposed and sued the EPA on numerous issues that are of great importance to the state of Maine, including mercury controls for coal-fired power plants and efforts to reduce cross-state air pollution and greenhouse gas emissions,” Collins said in a Wednesday statement first reported by Maine Public Radio.

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“His actions leave me with considerable doubts about whether his vision for the EPA is consistent with the agency’s critical mission to protect human health and the environment.”

Senators could vote on confirming Pruitt as early as Friday and despite Collins’s defection, Pruitt is still likely to be confirmed. The GOP's other 51 senators are likely to vote for him, and Sen. Joe Manchin Joseph (Joe) ManchinSenate leaders quash talk of rank-and-file COVID-19 deal OVERNIGHT ENERGY: House Democrats tee up vote on climate-focused energy bill next week | EPA reappoints controversial leader to air quality advisory committee | Coronavirus creates delay in Pentagon research for alternative to 'forever chemicals' Senate Democrats demand White House fire controversial head of public lands agency MORE (D-W.Va.) said he has “the right experience for the position.”

The rest of the Democratic caucus is likely to vote against Pruitt, who needs a simple majority of 51 votes to be confirmed.

Pruitt’s litigious history with the agency he wants to lead has been central to the campaign by Democrats and environmentalists against him.

He has sued to stop regulations controlling mercury pollution from power plants, carbon dioxide from power plants, a cleanup program for the Chesapeake Bay, ground-level ozone pollution, Obama’s rule asserting federal power over small waterways and more.

Pruitt and Republicans have defended the lawsuits as necessary to stop overreach by Obama’s EPA. Among the cases that have made it to a final court decision, Pruitt has been victorious just once.

Collins is one of the most centrist Republicans in the Senate, having broken with her party numerous times to support environmental regulations and legislation.

The Sierra Club applauded Collins Wednesday.

“Today, Senator Collins took a stand for families across Maine by opposing this dangerous nomination that would be a threat to our clean air, clean water, and public health,” Glen Brand, director of the group’s Maine chapter, said in a statement.

Collins's announcement came on the heels of a major blow for Trump's Cabinet slate, after Andy Puzder withdrew from consideration as Labor secretary one day before his confirmation hearing. She had expressed skepticism about his nomination, and also voted against final confirmation for Education Secretary Betsy DeVos.