GOP Sen. Susan Collins Susan Margaret CollinsClub for Growth to spend million in ads for Trump Supreme Court nominee Maryland's GOP governor says Republicans shouldn't rush SCOTUS vote before election The Hill's Morning Report - Sponsored by Facebook - GOP closes ranks to fill SCOTUS vacancy by November MORE (Maine) on Wednesday voted against a district judge nominee of President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE's who was considered controversial because of her views on abortion.

Republicans were able to break the filibuster on Wendy Vitter's nomination to be a judge in the Eastern District of Louisiana in a 51-45 vote, all but guaranteeing she will be confirmed on Thursday. But Collins, who is up for reelection in 2020, was the only GOP senator to oppose advancing Trump's pick.

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A spokeswoman for Collins confirmed that her vote against advancing Vitter Wednesday meant that she would also oppose her confirmation on Thursday.

Vitter is the wife of former Sen. David Vitter David Bruce VitterLysol, Charmin keep new consumer brand group lobbyist busy during pandemic Bottom line Bottom line MORE (R-La.), whose time in the Senate overlapped with Collins. Vitter has come under intense scrutiny for her views on abortion, including appearing at a rally opposing the construction of a Planned Parenthood clinic, where Vitter accused the group of "killing over 150,000 females a year."

At a 2013 conference Vitter appeared to back a brochure that linked abortions to breast cancer and taking birth control to an increased likelihood of violent relationships.

"Go to Dr. Angela's website, Breast Cancer Prevention Institute, download it, and at your next physical, you walk into your pro-life doctor and say, 'Have you thought about putting these facts or this brochure in your waiting room?' Each one of you can be the pro-life advocate to take that next step. That's what you do with it," she said at the conference, according to NPR.

Collins is one of a dwindling number of moderate, pro-choice Republicans in the Senate, and has broken with the administration on other nominations including Chad Readler's Sixth Circuit nomination in March.

Collins, at the time, linked her opposition to Readler to his role in a case involving pre-existing conditions.

Outside groups had targeted Collins ahead of the vote on Vitter's nomination.

The progressive group Demand Justice Initiative said it is launching a five-figure digital ad that will run on "prominent Maine websites," questioning why Collins would support Wendy Vitter's nomination.

"Trump nominee Wendy Vitter wants to shut down Planned Parenthood. So why would Senator Susan Collins vote for her?" the ad says.

A spokeswoman for Collins dismissed the ads as seeming "to be a large waste of money."