“The conclusion has become that the guy is incorrigible,” said Thomas M. Davis III, a former House member from Virginia who is still close to many of the party’s leaders. “He’s going to leave our candidates with no choice but to go their own separate way.”

Mr. Trump’s campaign did not respond to requests for comment, but on Friday night he tried to calm angry Republicans by endorsing, belatedly, the re-elections of Mr. Ryan and Senators John McCain of Arizona and Kelly Ayotte of New Hampshire. Mr. Trump had been feuding with them after they criticized his ridicule of the parents of Humayun Khan, a Muslim American Army captain killed in Iraq. Captain Khan’s parents had denounced Mr. Trump during the Democratic National Convention.

Reince Priebus, the chairman of the Republican National Committee, had urged Mr. Trump to stand behind Mr. Ryan and the senators for the sake of party unity. Some leading Republicans have expressed hope that Mr. Trump can at least stabilize his campaign by Labor Day, when many voters begin paying attention to congressional races.

But with such an erratic and belligerent candidate leading their ticket, many in the party have long seen a go-your-own-way strategy as inevitable.

David McIntosh, the president of the Club for Growth, a group that advocates small government, said the organization was studying how to get Republican voters who may dislike Mr. Trump to turn out for the party’s down-ballot candidates. Mr. McIntosh said the Club for Growth intended to convince voters that they would need a “strong voice in the Senate and House,” regardless of their feelings about the presidential race.

“You hope Trump does well so that the base Republican vote comes out and is strong,” Mr. McIntosh said. “But you also have to plan for if he doesn’t do well.”