We thank T. Sampson, L. Holst, and S. Pinches for the discovery of BPs, Muddy, and ZoeJ, respectively, and the students and faculty in the Mycobacterial Genetics Course at the University of KwaZulu Natal and in the SEA-PHAGES program for their contributions in isolating and characterizing the collection of phages used here. Further information about the phages, who isolated them and from where is available at https://phagesdb.org. We thank the Great Ormond Street Hospital staff in the Departments of Microbiology, Cell Therapy, and Pharmacy for excellent technical assistance, C. Murphy for assistance with strains and sera, J. Standing and B. Margetts for assistance with figures, D. Bain at the University of Pittsburgh for the ICP-MS analysis, and A. Betsko for electron microscopy. We greatly appreciate the advice of J. Hartley on regulatory aspects, and thank C. Hamilton for help with translation. We thank T. Mavrich for comments on the manuscript and we are grateful to S. Strathdee for general advice and comments on the manuscript. This work was funded by the National Institutes of Health (grant GM116884 to G.F.H.) and the Howard Hughes Medical Institute (grant 54308198 to G.F.H.).