A growing number of prescription medications can have serious, sometimes deadly, side effects when mixed with grapefruit, according to a study published this week in the Canadian Medical Association Journal.

Medical News Today (MNT) reports that researchers found more than 85 medications that may have some type of interaction with grapefruit, and that the number of drugs that could cause a dangerous reaction when paired with grapefruit has climbed from 17 to 43 in the past four years.

The report also suggests that health professionals and patients are often unaware of the possible side effects.

MNT explains that furanocoumarins found in grapefruit inhibit the body's CYP3A4 metabolizing enzyme from properly breaking down medications. As a result, more of the drug winds up in the bloodstream, and toxic drug levels or overdose can occur, resulting in:

respiratory failure

gastrointestinal bleeding

bone marrow suppression in patients with weak immune systems

renal toxicity

acute kidney failure

sudden death

An FDA Consumer Update on the matter was issued in February. The Mayo Clinic says pomelos and Seville oranges — a bitter variety used to make marmalades — may also have a similar effect.

ABC News says that as little as "one grapefruit or one 8-ounce glass of grapefruit juice can cause an effect that may last more than 24 hours," and reports the following A-Z partial list of medications believed to interact with grapefruit:

Alfentanil (oral)

Amiodarone

Apixaban

Atorvastatin

Buspirone

Clopidogrel

Crizotinib

Cyclosporine

Darifenacin

Dasatinib

Dextromethorphan

Domperidone

Dronedarone

Eplerenone

Erlotinib

Erythromycin

Everolimus

Felodipine

Fentanyl (oral)

Fesoterodine

Halofantrine

Ketamine (oral)

Latatinib

Lovastatin

Lurasidone

Maraviroc

Nifedipine

Nilotinib

Oxycodone

Pazopanib

Pimozide

Primaquine

Quinine

Quetiapine

Quinidine

Rilpivirine

Rivaroxaban

Silodosin

Simvastatin

Sirolimus

Solifenacin

Sunitinib

Tacrolimus

Tamsulosin

Ticagrelor

Triazolam

Vandetanib

Venurafenib

Verapamil

Ziprasidone

The Mayo Clinic also posts a partial list organized by drug type: