History of medical hydroxyapatite toothpastes

1970:

First synthetic form of hydroxyapatite created by NASA to help restore teeth and bone loss by astronauts following gravity-free environment missions.



1978:

Sangi Co., Ltd. acquires the patent from NASA and conceives the idea of an enamel-restorative toothpaste using the same substance as the tooth structure (hydroxyapatite).



1980:

Sangi launches the world’s first enamel-restorative toothpaste in Japan.



1985:

Studies from Tokyo Medical and Dental University (1 year / 1,026 children) and Asahi University (3 years / 181 children)

Results:

• Nano medical hydroxyapatite significantly lowered the incidence of new caries in previously and newly erupted teeth.

• In the 3-year study, the reduction was as high as 36 % to 56 %.



1993:

The Japanese government approves Sangi's proprietary medical hydroxyapatite as an active anti-caries agent.



