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Britney Spears took a huge amount of amphetamines the night she was strapped to a stretcher and placed on a 5150 hold -- so claims Sam Lutfi's lawyer in the opening statements of his defamation case.

Lutfi's lawyer, Joseph Schleimer, told the jury, on January 28, 2008, Britney had an amphetamine script filled. Schleimer says she took 6 to 8 pills early in the day, and several more later and went off the rails.

Lutfi's lawyer also said he tried to get Britney to meet with a psychiatrist 2 days before she was 5150'd, but Brit refused.