WASHINGTON -- President Barack Obama's inaugural budget sets the stage for an expansion of the federal work force and for hundreds of new rules that would widen Washington's involvement in the workings of private business.

If enacted by Congress, the budget initiatives will mark a clear end to the deregulatory philosophy of the Bush administration, signaling profound change for the nation's biggest businesses.

Mr. Obama envisions broad-based government hiring in the budget, from bomb detectors to food-safety inspectors. Some defense companies face a decline in Pentagon business, as the budget proposes to replace outside contractors with 33,600 civil servants by 2015. Other U.S. agencies would get authority to hire hundreds of additional workers, many in regulatory-enforcement jobs.

The budget also calls for tougher regulation of the food-processing and transportation industries, and beefed-up enforcement of workplace-safety and other labor practices.

The Food and Drug Administration would get an additional $300 million in the fiscal year beginning Oct. 1, the largest increase in the agency's history. The White House proposes increased manufacturer user fees to pay for food-plant inspections and to speed the review of applications for generic drugs and biologics, drugs derived from living organisms that are the industry's fastest-growing segment.