At least 12 people were killed and 80 injured when a vehicle hit a crowd of people in a popular area of Barcelona, Sky News and local media reported.

A rental van struck pedestrians in the Las Ramblas tourist area, in the center of the city in what local police are calling a terrorist attack.

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A look at the van that reportedly slammed into pedestrians in #Barcelona. Several ppl injured. Motive/cause unknown. pic.twitter.com/ezyPp289k8 — Kevin Rincon (@KevRincon) August 17, 2017

An eyewitness told Sky News described the scene, saying "the whole street started to run, screaming."

SKY NEWS: "The whole street started to run, screaming" - eyewitness describes what he saw as a massive crash happened in Barcelona hotspot. pic.twitter.com/gBkBqCx7tj — Josh Caplan (@joshdcaplan) August 17, 2017

One suspect is in custody, while a second suspect was killed by police after ramming a police checkpoint in a Ford Focus.

Earlier, local media said police were looking for Driss Oukabir, who rented the van used in the attack.

Police said there was no hostage situation at a nearby restaurant, contrary to some of the initial reporting.

ISIS has encouraged its supporters to use vehicles as weapons in lone-wolf attacks. Attacks of this type have taken place in Nice, France, London, Berlin and Stockholm.

The Las Ramblas area is a popular shopping area normally crowded in the summer with visitors.

Stay tuned to Fox News for updates on the developing story and read more, here.

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