The Myeloma 2016 meeting, was held in Boston, MA, between 22–24 April. Keith Stewart MB, ChB from the Mayo Clinic, discusses the day 1 highlights with Sagar Lonial, MD of the Winship Cancer Institute, Kenneth Anderson, MD of the Dana-Farber Cancer Institute, and Leif Bergsagel, MD of the Mayo Clinic. Here the experts discuss the possible targets of cellular immunotherapy, using CAR T-cells and BiTE as the vehicles; minimum residual disease (MRD), the new next-generation flow cytometry techniques available and its use in the drug approval process; among other treatment-related topics.