A violent case of road rage brought traffic to a standstill in Perth’s east Sunday morning.

A number of men were filmed wrestling and launching punches on a busy highway, oblivious to the cars around them.

Witnesses say there was a build up to the violence, with one car driving too close to another.

The tailgating eventually turned into a shocking act of aggression.

"All the other cars - they were stopped behind him, they were honking and all the cars around us, all the drivers and passengers got out to try to separate them," witness Jake Dragicevich told 7NEWS.

Eventually one of the heavy hitters retreated, but not before a final blow from his opponent.

So many witnesses were horrified by the level of violence that emergency services were flooded with calls from the public.

Both police and paramedics were called to the scene but no one was taken to hospital.

Those who saw the fight say they are still in shock.

"I didn't know what to think,” another witness said. “It was too fast.”

Police are calling for anyone else who witnessed the road rage to contact crime stoppers.