President Trump Donald John TrumpBubba Wallace to be driver of Michael Jordan, Denny Hamlin NASCAR team Graham: GOP will confirm Trump's Supreme Court nominee before the election Southwest Airlines, unions call for six-month extension of government aid MORE and the GOP establishment took a hit in Alabama on Tuesday as former state Supreme Court Chief Justice Roy Moore defeated incumbent Sen. Luther Strange Luther Johnson StrangeSessions hits back at Trump days ahead of Alabama Senate runoff The biggest political upsets of the decade State 'certificate of need' laws need to go MORE (R-Ala.) to become the Republican nominee for December’s Senate general election in the Yellowhammer State.

Moore won a comfortable victory in the primary runoff despite Trump and Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellGraham: GOP will confirm Trump's Supreme Court nominee before the election Trump puts Supreme Court fight at center of Ohio rally The Memo: Dems face balancing act on SCOTUS fight MORE (R-Ky.) backing Strange.

What were the main takeaways?

Trump backed the wrong man

Trump’s support for Strange always seemed incongruous.

Strange was seen as a creature of the establishment, both because he had the support of McConnell and because he had been appointed to the seat in the first place by Alabama's scandal-plagued former governor, Robert Bentley (R).

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Strange, who does not have a surfeit of charisma, took the seat that was vacated when Sen. Jeff Sessions Jefferson (Jeff) Beauregard SessionsGOP set to release controversial Biden report Trump's policies on refugees are as simple as ABCs Ocasio-Cortez, Velázquez call for convention to decide Puerto Rico status MORE became Trump’s attorney general.

Trump’s decision to back Strange in advance of the first stage of the GOP primary in early August was a controversial one, even among his allies.

Stephen Bannon, who was still Trump’s chief strategist at the time, was opposed to the move. Maverick GOP strategist and longtime Trump friend Roger Stone told The Hill on Monday that he believed Trump had been “conned” by liberal-leaning members of his own administration into backing Strange.

Trump himself seemed to have serious misgivings. At a rally for Strange in Huntsville last Friday, Trump even acknowledged that he may be making “a mistake.” The president also emphasized that he would campaign “like hell” for Moore if he became the nominee.

In the end, Trump was not able to pull his favored candidate across the winning line, even in a deeply conservative state that he won by almost 30 points over Democrat Hillary Clinton Hillary Diane Rodham ClintonJoe Biden looks to expand election battleground into Trump country Biden leads Trump by 12 points among Catholic voters: poll The Hill's Campaign Report: Biden goes on offense MORE last November.

The Moore win is not a lasting political wound for the president. But it is a black eye that he would much prefer to have avoided. Shortly after Strange's loss Tuesday night, Trump — or someone with access to his Twitter account — began deleting tweets Trump had sent praising "Big Luther" ahead of the runoff.

A serious defeat for McConnell

Beyond Strange himself, the biggest loser on Tuesday night was McConnell. The Senate majority leader stood four-square behind Strange. A super PAC associated with McConnell spent millions of dollars to try to sink Moore.

To many grassroots conservatives, however, McConnell’s support is more of a millstone than an asset. Back in July, only 30 percent of Republican voters approved of his job performance, according to a poll from the Democratic-leaning Public Policy Polling firm.

His standing has likely been weakened even further with the Senate GOP’s failure to pass legislation gutting the Affordable Care Act, also known as ObamaCare.

The McConnell-aligned super PAC, the Senate Leadership Fund, released a statement on Tuesday night announcing that it would back Moore in the general election.

But the firebrand conservative will owe nothing to McConnell and could cause him trouble in times to come.

Bragging rights for Bannon and Breitbart

Moore’s victory was as big a victory for Bannon and the news site he directs as it was a loss for McConnell and the establishment.

Bannon, fighting on the opposite side of Trump, had been clear in proclaiming Moore as the anti-establishment conservative taking on the entrenched powers in Washington.

At a rally for Moore on Sunday, Bannon described McConnell and his allies as “corrupt and incompetent.”

Introducing a victorious Moore on Tuesday night, Bannon heralded a “revolution” spearheaded by populists who “do not have to raise money from the elites, the crony capitalists, from the fat cats in Washington, D.C., New York City and Silicon Valley.”

Breitbart was just as celebratory. “Blowout in 'Bama,” its main headline proclaimed atop a homepage crammed full of headlines insisting, among other things, that the GOP establishment had been “brought to [its] knees.”

Bannon’s enemies within the GOP, of whom there are plenty, will roll their eyes at what they see as self-aggrandizement. But this was clearly a huge win for the pugnacious strategist and his acolytes.

Could more GOP senators eye the exit?

There was already big political news Tuesday even before the polls closed in Alabama: Incumbent GOP Sen. Bob Corker Robert (Bob) Phillips CorkerHas Congress captured Russia policy? Tennessee primary battle turns nasty for Republicans Cheney clashes with Trump MORE of Tennessee announced that he would retire when his current term ends next year.

Corker crossed swords with Trump last month when he criticized the president for a lack of “stability” and “competence” amid the uproar over Trump's response to racially charged violence in Charlottesville, Va.

To some seasoned Washington hands, it looked as if Corker was timing the announcement of his exit in order to avoid accusations that he was running scared of a primary challenge in his own state.

The Alabama result will only increase the scrutiny on other GOP incumbents, including Sens. Jeff Flake Jeffrey (Jeff) Lane FlakeJeff Flake: Republicans 'should hold the same position' on SCOTUS vacancy as 2016 Republican former Michigan governor says he's voting for Biden Maybe they just don't like cowboys: The president is successful, some just don't like his style MORE (Ariz.), Dean Heller Dean Arthur HellerOn The Trail: Democrats plan to hammer Trump on Social Security, Medicare Lobbying World Democrats spend big to put Senate in play MORE (Nev.) and Roger Wicker Roger Frederick WickerHillicon Valley: DOJ indicts Chinese, Malaysian hackers accused of targeting over 100 organizations | GOP senators raise concerns over Oracle-TikTok deal | QAnon awareness jumps in new poll Shakespeare Theatre Company goes virtual for 'Will on the Hill...or Won't They?' Republican Senators raise concerns over Oracle-TikTok deal MORE (Miss.). They all face threats — albeit of varying levels of credibility — from would-be primary challengers who could attract support from Bannon and allied groups.

Moore could give GOP heartburn

Alabama conservatives rallied to Moore’s banner, but he is a deeply controversial figure renowned for his incendiary statements.

Among his past pronouncements, he has argued that “homosexual conduct should be illegal,” has falsely suggested that former President Obama was not born in the United States and has asserted incorrectly that parts of Indiana and Illinois are under Islamic "Sharia law."

Moore was suspended from his state’s Supreme Court twice: Once for defying a court order to remove a statue of Christianity’s Ten Commandments from the state’s judicial building and, more recently, for instructing the state’s judges, in defiance of the U.S. Supreme Court, to refuse to issue marriage licenses to same-sex couples.

He will be a magnet for media attention, especially if he wins in December. There are plenty of his would-be colleagues in the Senate GOP who will not relish the idea of being forced to answer for some of his positions.

The Memo is a reported column by Niall Stanage, primarily focused on Donald Trump’s presidency.