Federal prosecutors likened infamous “Pharma Bro” Martin Shkreli to a master manipulator Tuesday, as they asked a judge to lock up him for 15 years at his looming sentencing for defrauding investors.

Saying the known gasbag failed to show “genuine remorse” for his actions, the 68-page document cites jailhouse communications between Shkreli and unidentified others as reason for Judge Kiyo Matsumoto to throw the book at him Friday.

“Shkreli was adept at finding what he thought people wanted to hear. And he molded himself accordingly to deceive and defraud,” prosecutors wrote, after citing the former pharma​ceutical​ exec’s arrogant communications.

“[F]–k the feds,” the 34-year-old wrote in one intercepted note. In another, he called his August 2017 conviction on three of eight charges a “loss for the government.”

And despite a whiny note to Matsumoto last week in which he begged for “mercy,” lauded himself as a supportive presence in the lives of his fellow “forlorn and forgotten” inmates, and said he was “far from blameless,” prosecutors unearthed another February missive in which he sounded less reflective.

“No one spends millions of dollars on drug projects out of the goodness of their hearts,” feds cite Shkreli as saying. “The people who put up the money have one thing on their mind: making more.”

While he could face more than 27 years behind bars under federal sentencing guidelines, Shkreli’s defense attorneys have called that possibility “draconian,” and previously asked that their client be given a much more lenient sentence of 12 to 18 months, with 2,000 hours of community service and court-mandated therapy.

Prosecutors said Tuesday any depiction of Shkreli as changed is “skewed.”

“It does not accurately reflect who he truly is — a man who stands before this Court without showing any genuine remorse, a man who has consistently chosen to put profit and the cultivation of a public image before all else,” they wrote, adding: “And a man who believes the ends always justifies the means.”

Matsumoto on Monday ordered Shkreli to forfeit almost $7.4 million — which could include his $2 million Wu-Tang album and a Picasso if he can’t access the ready cash.

Collection of those items was stalled, pending appeal.

Shkreli’s been behind bars since last September, after Matsumoto perceived Facebook postings offering $5,000 per strand of Hillary Clinton’s hair as a solicitation of a threat.

The convicted fraudster described the statuses as an “awkward attempt at humor or satire.”