At least one person was killed and four others wounded in a shooting in upper Manhattan late Sunday night, cops said.

The gunman approached one man and shot him in the head near West 136th and Broadway in Hamilton Heights at around 11:15 p.m., according to police.

As the shooter tried to make his escape, he fired multiple times and struck one 24-year-old male in the arm and ankle, another 22-year-old male in the stomach and two 21-year-old females in the shoulder.

The two males were taken to Harlem Hospital and listed in stable condition.

The two females were transported to St. Luke’s and listed in stable condition. Cops were searching for the gunman.