Jarryd Hayne's State of Origin ambitions have taken a blow with a suspected syndesmosis injury set to sideline the Gold Coast Titans fullback for at least a month.

The hero of the 2014 series-winning NSW Blues team has been part of Laurie Daley's plans based on his past deeds but the ankle injury sustained in the Titans' defeat to Newcastle on Saturday will leave him with a more limited opportunities to ram home his selection credentials.

Hayne will have scans on Monday and they are expected to confirm that he will be out of action until midway through next month.

"He had an ankle that was twice the size what it should be yesterday," Titans chief executive Graham Annesley told Fairfax Media on Sunday.