A man has been arrested following a collision in Melbourne’s south-east, which left a cyclist in a critical condition.

Police have arrested a 28-year-old Parkdale man in Broadmeadows after a woman in her 40s was struck travelling along the Nepean Highway in Chelsea about 5.45am.

Police alleged the man driving a white ute then fled the scene. The car was located in Seaford about 8.15am.

The woman was taken to The Alfred Hospital suffering life-threatening head injuries.

The Nepean Highway was closed to traffic in both directions near the Chelsea Train Station, VicRoads confirmed.

Investigators want to speak to anyone who may have CCTV or dash cam footage in the lead up or time of the accident.