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David Cameron today claimed ISIS supports a 'Leave' vote in the EU referendum .

In his starkest warning yet about the perils of ' Brexit ', the PM said murderous Islamic State boss Abu Bakr al-Baghdadi and hardman Russian President Vladimir Putin both want Britain to pull out of the EU.

“Who would be happy if we left?” the PM asked an audience in London.

“Putin might be happy. I suspect al-Bagdadi might be happy.”

(Image: Getty)

Mr Cameron urged Brits to 'listen to our friends' when deciding how to vote on June 23, pointing to calls from the US, Canada, Australia and the rest of Europe for Britain to vote to Remain.

The PM also slapped down Nigel Farage for suggesting a narrow victory for Remain could lead to a second referendum.

Mr Farage told the Mirror yesterday : "In a 52-48 referendum this would be unfinished business by a long way."

But Mr Cameron said it was clear 'Leave' campaigners are now preparing for defeat, and vowed the June 23 poll will be a 'once in a lifetime' event.

“I think when people start arguing for a second referendum before you've even had the first one, that really demonstrates you are losing the argument," the PM told the Mirror.

“I'm absolutely clear that the referendum is the referendum. It is a once in a generation, once in a lifetime opportunity.

The result determines the outcome – if we vote to stay, we stay, and that's it. If we vote to leave, we leave, and that's it.

“We can't have 'never-endums'.”

Mr Farage will get the opportunity to respond this afternoon when he appears at the Mirror's big EU debate , which is being live-streamed on our website.

(Image: Philip Coburn/Daily Mirror)

He will also hit back at the PM's inflammatory remarks over ISIS, amid accusations the PM is running a 'Project Fear' campaign to keep Britain in the EU.

Speaking this morning Mr Cameron insisted he is running a 'positive' campaign but said he 'makes no apology' for also warning about the danger of cutting ties with Britain's biggest trading partner .

“I really think there are dangers,” the PM said.

“There are dangers about losing the terrorist information we share with our European partners.

“There are dangers that Britain's role in the world would be diminished. And yes there would be big economic dangers.

“I think it would be wrong for me as Prime Minister not to listen to the views of the IMF, the Bank of England... if we leave, growth would would lower, unemployment would be higher, prices would rise; we would have less economic security in our country.”

“I don't want anyone going to the polls on June 23 not knowing what a big risk there is to Britain leaving this organisation.”