1. Buy Aprecap 125mg Online

Aprepitant is an active ingredient of Aprecap drug which is put under the anti-cancer category. It is available in capsule form and is prescribed for both men and women. This drug is often prescribed to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy). An antiemetic chemical compound belongs to a class of drugs called substance P antagonists (SPA).

2. How To Aprecap 125mg Work?

Aprecap capsules contain aprepitant, a selective high-affinity antagonist of the substance P neurokinin 1 (NK1) receptor.

The vomiting centre contains high concentrations of substance P and its receptor neurokinin 1 (NK1), in addition to other receptors for neurotransmitters like serotonin (5HT) and dopamine.

Substance P is released by nerve cells in response to stressful stimuli such as toxins and the biological effects of substance P, including emesis, are triggered by the binding of substance P to its NK1 receptor.

Substance P belongs to a group of neurokinins (NKs), which are small neurotransmitters, or chemical messengers that transmit signals to and from the neurones (brain cells), and it has an important role triggering emesis (vomiting).

The vomiting reflex is triggered by stimulation of vomiting centre in the brain, which is a complex area of neuronal networks, by one of several afferent nerve pathways (nerve signals carried to the brain).

This can activate vomiting via one of several neurotransmitter receptors. The chemoreceptor trigger zone (CTZ) is one of these afferent nerve pathways and is located in the area postrema of the brain, which is not protected by the blood-brain barrier and therefore, is readily accessible to circulating toxins and drugs.

Aprepitant in Aprecap capsules competitively binds to NK1 receptors, which blocks the binding of substance P to its receptor and this prevents signal transduction that induces the vomiting reflex.

Chemotherapy can also cause the release of serotonin (5HT) from the cells of the small intestine, which stimulates 5HT3 receptors that are found on the vagal nerves in the intestines, sending signals to the vomiting centre in the brain, and this is another afferent pathway that induces the vomiting reflex.

Standard therapy for preventing nausea and vomiting following chemotherapy includes a serotonin receptor antagonist, as well as an anti-inflammatory corticosteroid.

Aprepitant in Aprecap capsules combined with standard therapy augments the antiemetic effects to improve protection against emetogenic chemotherapy.

3. How To Take Aprecap 125mg capsules?

You should take your Aprecap capsules swallowed whole, with a glass of water, with or without food, as part of a 3-day regimen that includes a corticosteroid and a 5-HT3 antagonist. You should take your first capsule (125mg) on day 1, one hour before starting chemotherapy. You should take your next two capsules (80mg) once daily on days 2 and 3 in the morning. You should take your Aprecap capsules in addition to other antiemetic medications as recommended by your doctor.

4. Drug interaction of Aprecap 125mg

Several medications interact with Aprecap capsules and should either not be taken while you are taking Aprecap or only after discussion and instruction from your doctor:

Drugs that cause a serious reaction with Aprecap: the antipsychotic pimozide, the antihistamines terfenadine and astemizole, cisapride for reflux,

Drugs that affect Aprecap: the antifungal ketoconazole, the antibiotic rifampicin, the antidepressant paroxetine, diltiazem for high blood pressure, St John's Wort

Drugs that are affected by Aprecap: the anticoagulant warfarin, hormonal contraceptives, the sedative midazolam, tolbutamide for diabetes, the antidepressant paroxetine, diltiazem for high blood pressure

5. Side Effects of Aprecap 125mg

The most commonly reported side effects when taking Aprecap include,

constipation,

dyspepsia (heartburn),

decreased appetite,

hiccups,

headache,

asthenia (weakness),

fatigue.

6. Warning And Precaution of Aprecap 125mg capsules

It’s important that you are allergic or suffering from other allergies before using Aprepitant.

This substance may contain inactive ingredients, which can cause allergic reactions or other problems, so be careful for that.

Use Aprepitant with extreme caution in children as safety and effectiveness in children have not been assured yet.

Talk to your pharmacist and discuss your medical history with your doctor.

During pregnancy, this medication should be taken only when firmly prescribed. It is not known if this drug passes into breast milk. Consult your doctor before breastfeeding.

Discuss the risks and benefits of Aprepitant with your doctor.

7. Aprecap 125mg Dosage

Recommended dose:

Usually, Aprepitant is taken once every day, with or without food, during the initial days of cancer chemotherapy. Doctors recommend Aprepitant one hour before the first dose of chemotherapy. After that, patients can take it in the morning for the next few days. One has to follow the directions on how much and when to take this medicine. More or less dosage of Aprepitant may harm your body, so take it as prescribed by the expert.

Method of Administration:

Aprepitant comes as a capsule that you can take orally. Its capsules come in two strengths that are prescribed to take at different times. Only your doctor can direct how much strength is needed to prevent nausea and vomiting. It’s usually taken during first 3 days of chemotherapy administration.

Missed dose

You are not supposed to miss a dose of aprepitant and take it according to the prescribed schedule. In case you miss a dose, contact your doctor or pharmacist immediately to confirm your medical condition and get a new dosing schedule.

Overdose:

An overdose of any medicine is not good for health. If you suspect having taken the overdose of Aprepitant, then contact your doctor immediately to understand its consequences. The waves of nausea and vomiting are possible in overdose.

Forms and Strengths:

Aprepitant is available in 125mg/80mg Kit under the brand name Aprecap.

8. Uses of Aprecap 125mg

Aprecap capsules are used to prevent nausea and vomiting associated with cancer chemotherapy and are used as combination therapy with other mediations for both highly and moderately emetogenic (vomiting inducing) chemotherapy. Chemotherapy is the use of cytotoxic drugs to kill cancer cells, which grow more rapidly than most normal cells, and nausea and vomiting are common side effects of chemotherapy. Drugs used for chemotherapy stimulate the vomiting reflex that is triggered in the brain. Aprecap capsules block the vomiting reflex and prevent nausea and vomiting induced by these drugs.

9. Storage of Aprecap 125mg

You should store your Aprecap capsules below 25°C in a cool dry place.