ISLAMABAD, Pakistan  A Pakistani passenger plane crashed in fog and intense rain in the Himalayan foothills near this capital city on Wednesday morning, killing all 152 people on board in the country’s deadliest domestic plane crash, according to civil aviation and airline officials.

Rescue helicopters fought against thick smoke and flames as they tried to find survivors amid the wreckage  at least an hour’s drive into the high ground above Islamabad  but hours after the crash, Pakistani officials said that none of the 146 passengers or 6 crew members had survived.

Grief-stricken relatives had gathered at Islamabad’s airport hoping for word on survivors. Six members of the Youth Parliament of Pakistan had been aboard.

President Obama issued a statement confirming that two Americans had been on the flight and expressing condolences to the families and friends of all who died, saying, “Our thoughts and prayers go out to all of those touched by this horrible accident.”