Kratom Withdrawal Symptoms

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Kratom (Mitragyna speciosa) is an evergreen tree from the Rubiaceae (coffee) family that produces leaves containing numerous psychoactive compounds, most notably including indole alkaloids: 7-hydroxymitragynine, mitraphylline, and mitragynine. When ingested by humans, the aforestated indole alkaloids significantly modulate CNS activity primarily via partial agonism of mu-opioid receptors (MORs). In addition, evidence from pharmacodynamic investigations suggests that kratom’s alkaloids also: antagonize kappa-opioid receptors (KORs) and delta-opioid receptors (DORs); agonize alpha-2 receptors; antagonize 5-HT2A receptors; and antagonize adenosine A2A receptors.

The cumulative physiologic effect of the aforestated pharmacodynamics tends to induce [a combination of]: analgesia, sedation, and/or stimulation. Interestingly, the dose-response curve of kratom is thought to [generally] yield greater analgesia/sedation than stimulation at high doses, but greater stimulation than analgesia/sedation at low doses. While kratom is not scientifically-substantiated as an intervention for any medical condition, its popularity has skyrocketed in recent years as an alternative treatment for chronic pain, opiate/opioid dependence, and opiate/opioid withdrawal.

It has also garnered popularity for the management of neuropsychiatric conditions such as generalized anxiety disorder, major depressive disorder, and social phobia – and remains commonly utilized as a recreational euphoriant/intoxicant. Since kratom is classified as an herbal supplement and remains legal in many states, a subset of individuals mistakenly assume that it can be used regularly and eventually discontinued without any withdrawal symptoms. In reality, most individuals who use kratom on a regular basis will experience some withdrawal symptoms following cessation.

Kratom Withdrawal Symptoms: List of Possibilities

Although many pharmaceutical drugs are heavily criticized by former users for their oft-debilitating withdrawal symptoms, it is less common for “all natural” and/or herbal supplements like kratom to receive similar criticism – even if warranted. What’s worse, in some cases, individuals who report kratom side effects and/or withdrawal symptoms online are condemned by kratom advocates who suggest that such experiences are an impossibility. Various [invalid] reasons that kratom withdrawal is said not to occur include: because kratom is 100% natural; because there are no published data documenting kratom withdrawal; because kratom is [technically] not an opioid/opiate; and/or because they (the kratom advocates) have never [personally] experienced any unwanted effects after stopping kratom.

That said, a simplistic analysis of kratom’s pharmacodynamic profile underscores the fact that its alkaloidal constituents exert a potent psychoactive effect through the opioid system. With regular or consistent administration of kratom over a long-term, physiologic adaptations will occur, including: upregulation and/or downregulation of receptors, altered secretion of neurotransmitters and/or hormones; and upregulation of hepatic isoenzymes implicated in kratom metabolism. As a result, when an individual ceases kratom usage after a long-term, his/her physiology transitions from “kratom-adapted” to [pre-kratom] homeostasis.

During the aforementioned transitory period, withdrawal symptoms are likely to occur in any regular kratom user. For most, kratom withdrawal symptoms will be of greatest severities in the early days and/or weeks of cessation, but less severe the longer a person has maintained abstinence. Moreover, countless anecdotes are circulating online to support the idea that withdrawal symptoms can occur after kratom discontinuation. Included below is a comprehensive list of kratom withdrawal symptoms that have been reported by former users.

Agitation : After quitting kratom, don’t be surprised if you experience surges of agitation. Agitation is best described as internal nervousness and/or excitable discomfort that’s generally associated with anxiety and restlessness. During withdrawal, you may end up frustrated that you feel completely fatigued, yet simultaneously so agitated that you cannot stop fidgeting or pacing around the house. Although agitation may seem most severe in early stages of withdrawal, it generally becomes more manageable after the first few weeks of cessation. To cope with agitation during kratom withdrawal, some will find it helpful to: utilize relaxation techniques (e.g. meditation) and/or to engage in mild physical exercise (e.g. going for a walk outside) – each of which can help reduce sympathetic tone and corresponding agitation. Others may only find relief from agitation with prescription medications and/or dietary supplements.

: After quitting kratom, don’t be surprised if you experience surges of agitation. Agitation is best described as internal nervousness and/or excitable discomfort that’s generally associated with anxiety and restlessness. During withdrawal, you may end up frustrated that you feel completely fatigued, yet simultaneously so agitated that you cannot stop fidgeting or pacing around the house. Although agitation may seem most severe in early stages of withdrawal, it generally becomes more manageable after the first few weeks of cessation. To cope with agitation during kratom withdrawal, some will find it helpful to: utilize relaxation techniques (e.g. meditation) and/or to engage in mild physical exercise (e.g. going for a walk outside) – each of which can help reduce sympathetic tone and corresponding agitation. Others may only find relief from agitation with prescription medications and/or dietary supplements. Aggression : While under the influence of kratom, some individuals experience a serenic effect characterized by internal peace, social tolerance, and patience with others. That said, following kratom discontinuation, many will experience the opposite of serenity such that they become aggressive and/or hostile. In most cases, aggression and/or hostility tends to emerge within the first few weeks of kratom withdrawal and slowly diminishes thereafter. The cause of aggression may be due to a combination of: neurochemical imbalances, autonomic dysfunction, and/or other withdrawal symptoms (e.g. sleep disturbances). Nevertheless, if you become aggressive during kratom withdrawal, you may want to develop a plan to ensure that the aggression is handled before it escalates to [potential] verbal abuse and/or physical assaults – each of which may damage relationships and/or reputation. In other words, know how you’re going to cope with aggression, so that when it occurs, you don’t go through with a regrettable action. Examples of ways in which you may be able to manage withdrawal-related aggression include: going for a walk, lifting weights, boxing at the gym, deep breathing, meditation, or listening to peaceful music.

: While under the influence of kratom, some individuals experience a serenic effect characterized by internal peace, social tolerance, and patience with others. That said, following kratom discontinuation, many will experience the opposite of serenity such that they become aggressive and/or hostile. In most cases, aggression and/or hostility tends to emerge within the first few weeks of kratom withdrawal and slowly diminishes thereafter. The cause of aggression may be due to a combination of: neurochemical imbalances, autonomic dysfunction, and/or other withdrawal symptoms (e.g. sleep disturbances). Nevertheless, if you become aggressive during kratom withdrawal, you may want to develop a plan to ensure that the aggression is handled before it escalates to [potential] verbal abuse and/or physical assaults – each of which may damage relationships and/or reputation. In other words, know how you’re going to cope with aggression, so that when it occurs, you don’t go through with a regrettable action. Examples of ways in which you may be able to manage withdrawal-related aggression include: going for a walk, lifting weights, boxing at the gym, deep breathing, meditation, or listening to peaceful music. Anger : In most cases, individuals will report feeling calm and relaxed under the influence of kratom. However, when kratom is discontinued after an extended duration of regular ingestion, strong unwanted or negative emotions such as anger may emerge. The emergence of anger likely stems from a combination of excessive excitatory transmission (particularly norepinephrine) and overactivation of the sympathetic nervous system. As a result, a subset of persons will feel short-tempered and more angry than usual during kratom withdrawal. Because anger is caused by withdrawal-related physiologic imbalances, it may be difficult to control. That said, if you’re experiencing anger as a withdrawal symptom, you may want to make a list of attenuation strategies to implement so that it doesn’t escalate to complete rage and/or lead to the mistreatment of others. Moreover, anyone dealing with excessive anger should be encouraged to seek professional help from a psychotherapist and/or psychiatrist.

: In most cases, individuals will report feeling calm and relaxed under the influence of kratom. However, when kratom is discontinued after an extended duration of regular ingestion, strong unwanted or negative emotions such as anger may emerge. The emergence of anger likely stems from a combination of excessive excitatory transmission (particularly norepinephrine) and overactivation of the sympathetic nervous system. As a result, a subset of persons will feel short-tempered and more angry than usual during kratom withdrawal. Because anger is caused by withdrawal-related physiologic imbalances, it may be difficult to control. That said, if you’re experiencing anger as a withdrawal symptom, you may want to make a list of attenuation strategies to implement so that it doesn’t escalate to complete rage and/or lead to the mistreatment of others. Moreover, anyone dealing with excessive anger should be encouraged to seek professional help from a psychotherapist and/or psychiatrist. Anxiety : Though kratom is regarded by many as an effective anxiolytic, its anxiolytic effect usually diminishes over time due to onset of physiologic tolerance. As tolerance develops, neurobiology adjusts such that the locus coeruleus upregulates its transmission of norepinephrine [to offset CNS depression induced by mu-opioid receptor agonism]. When kratom usage ceases, the former-user no longer exhibits mu-opioid receptor-induced CNS suppression, but retains upregulated noradrenergic signaling with excessive sympathetic activation. Predictably, this leads to a combination of psychological and physical symptoms of anxiety during withdrawal until noradrenergic transmission normalizes. While many individuals will experience varying degrees of anxiety during withdrawal, the withdrawal-related anxiety may be most severe for persons with preexisting anxiety disorders. To cope with the anxiety, it may be necessary to utilize relaxation techniques (e.g. deep breathing), stay physically active, and/or consult a psychiatrist for prescription anti-anxiety medications.

: Though kratom is regarded by many as an effective anxiolytic, its anxiolytic effect usually diminishes over time due to onset of physiologic tolerance. As tolerance develops, neurobiology adjusts such that the locus coeruleus upregulates its transmission of norepinephrine [to offset CNS depression induced by mu-opioid receptor agonism]. When kratom usage ceases, the former-user no longer exhibits mu-opioid receptor-induced CNS suppression, but retains upregulated noradrenergic signaling with excessive sympathetic activation. Predictably, this leads to a combination of psychological and physical symptoms of anxiety during withdrawal until noradrenergic transmission normalizes. While many individuals will experience varying degrees of anxiety during withdrawal, the withdrawal-related anxiety may be most severe for persons with preexisting anxiety disorders. To cope with the anxiety, it may be necessary to utilize relaxation techniques (e.g. deep breathing), stay physically active, and/or consult a psychiatrist for prescription anti-anxiety medications. Appetite changes : You may experience a subtle or significant shift in appetite during kratom withdrawal. In some cases, appetite shifts during withdrawal are the exact opposite of appetite while under the influence of kratom. For example, certain individuals who experience an increased appetite while taking kratom may experience appetite suppression during withdrawal; and vice-versa. Appetite changes may also be contingent upon specific symptoms that emerge throughout withdrawal. In other words, someone with severe nausea and dizziness during withdrawal may struggle with food consumption. Moreover, any appetite changes that occur during withdrawal may lead to noticeable changes in body weight. Nonetheless, within several months of kratom cessation most individuals will experience stabilization of appetite.

: You may experience a subtle or significant shift in appetite during kratom withdrawal. In some cases, appetite shifts during withdrawal are the exact opposite of appetite while under the influence of kratom. For example, certain individuals who experience an increased appetite while taking kratom may experience appetite suppression during withdrawal; and vice-versa. Appetite changes may also be contingent upon specific symptoms that emerge throughout withdrawal. In other words, someone with severe nausea and dizziness during withdrawal may struggle with food consumption. Moreover, any appetite changes that occur during withdrawal may lead to noticeable changes in body weight. Nonetheless, within several months of kratom cessation most individuals will experience stabilization of appetite. Brain fog : Another extremely common symptom that emerges after kratom cessation is brain fog. If you feel as though you’re constantly spaced-out, zombie-like, as if your head is in the clouds – you’ve experienced the brain fog. Some describe brain fog as though their brain is operating at 50% or even 25% of its normal speed such that they feel mentally slow, stuck in a daydream-like state around others. The cause of brain fog during kratom withdrawal is imbalanced physiology. With enough time kratom-free, the fog should gradually lift and your thinking will become clearer.

: Another extremely common symptom that emerges after kratom cessation is brain fog. If you feel as though you’re constantly spaced-out, zombie-like, as if your head is in the clouds – you’ve experienced the brain fog. Some describe brain fog as though their brain is operating at 50% or even 25% of its normal speed such that they feel mentally slow, stuck in a daydream-like state around others. The cause of brain fog during kratom withdrawal is imbalanced physiology. With enough time kratom-free, the fog should gradually lift and your thinking will become clearer. Chills : Experiencing the “chills” and/or shivers is a relatively common during kratom withdrawal. Many speculate that withdrawal-related chills are a byproduct of thermoregulatory abnormalities associated with irregular neurotransmitter and/or hormone secretion. As a result, body temperature may fluctuate significantly, sweat production may increase, and chills may result. If you’re sweating a lot, it’s likely that the excessive sweat is directly contributing to the chilled feelings. Furthermore, since kratom’s action can increase body temperature (via mu-opioid receptor agonism and kappa-opioid receptor antagonism), it’s possible that there’s an adaptive physiologic effect of upregulated internal cooling. It’s possible that increased internal cooling lingers during withdrawal, and without action of kratom on opioid receptors to induce mild hyperthermia, individuals may feel chilled or downright cold during withdrawal. For a majority of individuals, the chills reach a peak in the first couple weeks of kratom detox and improve thereafter. Some claim that taking a hot shower, using a sauna, or taking a bath with Epsom salts can reduce the chills. Staying hydrated, maintaining electrolyte balance, eating a balanced diet, and/or using pharmacological interventions may also prove helpful.

: Experiencing the “chills” and/or shivers is a relatively common during kratom withdrawal. Many speculate that withdrawal-related chills are a byproduct of thermoregulatory abnormalities associated with irregular neurotransmitter and/or hormone secretion. As a result, body temperature may fluctuate significantly, sweat production may increase, and chills may result. If you’re sweating a lot, it’s likely that the excessive sweat is directly contributing to the chilled feelings. Furthermore, since kratom’s action can increase body temperature (via mu-opioid receptor agonism and kappa-opioid receptor antagonism), it’s possible that there’s an adaptive physiologic effect of upregulated internal cooling. It’s possible that increased internal cooling lingers during withdrawal, and without action of kratom on opioid receptors to induce mild hyperthermia, individuals may feel chilled or downright cold during withdrawal. For a majority of individuals, the chills reach a peak in the first couple weeks of kratom detox and improve thereafter. Some claim that taking a hot shower, using a sauna, or taking a bath with Epsom salts can reduce the chills. Staying hydrated, maintaining electrolyte balance, eating a balanced diet, and/or using pharmacological interventions may also prove helpful. Cognitive deficits : Among academics and/or persons involved in cognitively-demanding occupations, the most frustrating of all kratom withdrawal symptoms may be cognitive deficits. Those experiencing cognitive deficits during withdrawal may notice that aspects of executive function such as: attention, critical thinking, planning, reasoning, self-regulation, working memory, etc. – are impaired. It is likely that a majority of cognitive deficits occurring during withdrawal are primarily due to imbalanced neurochemistry. Furthermore, preoccupation with certain withdrawal symptoms (e.g. jitters) may directly interfere with aspects of cognition. As neurochemistry reverts back to homeostasis and other withdrawal symptoms become less noticeable, cognitive function should improve and stabilize. Because cognitive impairment during withdrawal could compromise academic or occupational performance, it may be smart to: take some time off from work/school, utilize supplements that support brain function, and/or seek pharmacological interventions from a psychiatrist.

: Among academics and/or persons involved in cognitively-demanding occupations, the most frustrating of all kratom withdrawal symptoms may be cognitive deficits. Those experiencing cognitive deficits during withdrawal may notice that aspects of executive function such as: attention, critical thinking, planning, reasoning, self-regulation, working memory, etc. – are impaired. It is likely that a majority of cognitive deficits occurring during withdrawal are primarily due to imbalanced neurochemistry. Furthermore, preoccupation with certain withdrawal symptoms (e.g. jitters) may directly interfere with aspects of cognition. As neurochemistry reverts back to homeostasis and other withdrawal symptoms become less noticeable, cognitive function should improve and stabilize. Because cognitive impairment during withdrawal could compromise academic or occupational performance, it may be smart to: take some time off from work/school, utilize supplements that support brain function, and/or seek pharmacological interventions from a psychiatrist. Confusion : In the acute stages of kratom withdrawal, you might experience confusion where you find it difficult to make sense of conversations and/or learn new material. The confusion goes hand-in-hand with the other symptoms of brain fog and cognitive deficits. Some claim that their thoughts and/or speech seems incoherent due to the confusion and corresponding lack of mental clarity. Although the confusion may be frustrating, realize that with enough time and proper recovery efforts, your neurochemistry should recover and the incoherent or blurred consciousness should abate.

: In the acute stages of kratom withdrawal, you might experience confusion where you find it difficult to make sense of conversations and/or learn new material. The confusion goes hand-in-hand with the other symptoms of brain fog and cognitive deficits. Some claim that their thoughts and/or speech seems incoherent due to the confusion and corresponding lack of mental clarity. Although the confusion may be frustrating, realize that with enough time and proper recovery efforts, your neurochemistry should recover and the incoherent or blurred consciousness should abate. Cravings : The alkaloids within kratom are known to modulate neurochemistry such that, with each high-dose, the reward center of the brain is activated. As a result, individuals who use kratom regularly associate it with pleasurable feelings of intoxication. When these same individuals discontinue kratom, many will experience psychological cravings, urges, and desires to reinstate usage. This is because their reward center is no longer receiving the supraphysiologic stimulation provided by the kratom. Moreover, signaling of dopamine is reduced during withdrawal, leading the user’s brain to initiate cravings for more kratom – which would temporarily augment dopaminergic signaling. If you’re struggling to deal with cravings during withdrawal, it is recommended to seek out the help of a licensed psychologist and/or psychiatrist. To avoid a craving-induced relapse after discontinuation, avoid keeping extra kratom around the house, get rid of possessions you’ve mentally associated with kratom, and avoid persons who may pressure you to into using kratom. In general, the longer you’ve maintained abstinence, the lesser your cravings should be. Someone who’s been kratom-free for 6 months probably won’t experience many cravings compared to someone who’s been kratom-free for just 1-month.

: The alkaloids within kratom are known to modulate neurochemistry such that, with each high-dose, the reward center of the brain is activated. As a result, individuals who use kratom regularly associate it with pleasurable feelings of intoxication. When these same individuals discontinue kratom, many will experience psychological cravings, urges, and desires to reinstate usage. This is because their reward center is no longer receiving the supraphysiologic stimulation provided by the kratom. Moreover, signaling of dopamine is reduced during withdrawal, leading the user’s brain to initiate cravings for more kratom – which would temporarily augment dopaminergic signaling. If you’re struggling to deal with cravings during withdrawal, it is recommended to seek out the help of a licensed psychologist and/or psychiatrist. To avoid a craving-induced relapse after discontinuation, avoid keeping extra kratom around the house, get rid of possessions you’ve mentally associated with kratom, and avoid persons who may pressure you to into using kratom. In general, the longer you’ve maintained abstinence, the lesser your cravings should be. Someone who’s been kratom-free for 6 months probably won’t experience many cravings compared to someone who’s been kratom-free for just 1-month. Delirium : Although rare, a person may experience delirium characterized by abnormal speech, bizarre perceptions, grossly disorganized thinking, and restlessness. Most individuals who experience delirium as a withdrawal symptom will have discontinued kratom too rapidly after long-term and/or high-dose usage. Some suspect that persons with preexisting neuropsychiatric conditions and/or age-related cognitive decline may be more vulnerable to delirium during withdrawal than others. That said, in most cases the delirium will be short-lived and shouldn’t persist for more than a week. Anyone who experiences delirium in withdrawal is recommended to seek emergency medical evaluation and care.

: Although rare, a person may experience delirium characterized by abnormal speech, bizarre perceptions, grossly disorganized thinking, and restlessness. Most individuals who experience delirium as a withdrawal symptom will have discontinued kratom too rapidly after long-term and/or high-dose usage. Some suspect that persons with preexisting neuropsychiatric conditions and/or age-related cognitive decline may be more vulnerable to delirium during withdrawal than others. That said, in most cases the delirium will be short-lived and shouldn’t persist for more than a week. Anyone who experiences delirium in withdrawal is recommended to seek emergency medical evaluation and care. Depersonalization : At some point during kratom withdrawal, you may experience depersonalization. If you’re depersonalized, you may feel unlike your normal self and may actually panic because your current state of consciousness and/or perception of reality seems skewed. The problem with panicking and/or becoming anxious about feeling depersonalized during withdrawal is that increased anxiety tends to exacerbate the depersonalization. It is recommended to avoid dwelling on the depersonalization, as this can also lead to anxiety. Staying active, using relaxation techniques to counteract stress, and/or dietary supplements may prove useful for mitigating depersonalized feelings. Symptoms that are synonymous with depersonalization include: derealization (feeling as if your surroundings are not real) and dissociation (feeling disconnected from reality).

: At some point during kratom withdrawal, you may experience depersonalization. If you’re depersonalized, you may feel unlike your normal self and may actually panic because your current state of consciousness and/or perception of reality seems skewed. The problem with panicking and/or becoming anxious about feeling depersonalized during withdrawal is that increased anxiety tends to exacerbate the depersonalization. It is recommended to avoid dwelling on the depersonalization, as this can also lead to anxiety. Staying active, using relaxation techniques to counteract stress, and/or dietary supplements may prove useful for mitigating depersonalized feelings. Symptoms that are synonymous with depersonalization include: derealization (feeling as if your surroundings are not real) and dissociation (feeling disconnected from reality). Depression : Kratom can enhance mood and/or generate an antidepressant effect through modulation of many neurotransmitter systems. For example, kratom-induced activation of mu-opioid receptors stimulates the ventral tegmental area (VTA) within the mesolimbic reward pathway to release dopamine in the nucleus accumbens (NAc). As a result, individuals experience a sense of euphoria and/or pleasure. Over time, the brain adapts to this effect and becomes less responsive to mu-opioid receptor activation (possibly via receptor upregulation) whereby the antidepressant and/or mood enhancing effects subside unless the dosage is increased. When kratom is discontinued, the neuroadaptation that diminished kratom’s antidepressant effect lingers, and since kratom is no longer generating mood enhancement, former users are prone to apathy and/or bouts of depression. Individuals with preexisting neuropsychiatric conditions, especially major depressive disorder, may be most vulnerable to withdrawal-related depression. If the depression feels overwhelming and/or leads to suicidal thoughts, do not hesitate to seek immediate medical attention from a psychiatrist. Staying socially engaged, physically active, eating a balanced diet, maintaining a sleep regimen, and utilizing specific supportive supplements may expedite recovery from lingering depression in withdrawal.

: Kratom can enhance mood and/or generate an antidepressant effect through modulation of many neurotransmitter systems. For example, kratom-induced activation of mu-opioid receptors stimulates the ventral tegmental area (VTA) within the mesolimbic reward pathway to release dopamine in the nucleus accumbens (NAc). As a result, individuals experience a sense of euphoria and/or pleasure. Over time, the brain adapts to this effect and becomes less responsive to mu-opioid receptor activation (possibly via receptor upregulation) whereby the antidepressant and/or mood enhancing effects subside unless the dosage is increased. When kratom is discontinued, the neuroadaptation that diminished kratom’s antidepressant effect lingers, and since kratom is no longer generating mood enhancement, former users are prone to apathy and/or bouts of depression. Individuals with preexisting neuropsychiatric conditions, especially major depressive disorder, may be most vulnerable to withdrawal-related depression. If the depression feels overwhelming and/or leads to suicidal thoughts, do not hesitate to seek immediate medical attention from a psychiatrist. Staying socially engaged, physically active, eating a balanced diet, maintaining a sleep regimen, and utilizing specific supportive supplements may expedite recovery from lingering depression in withdrawal. Diarrhea : Another extremely common kratom withdrawal symptom that you may experience is diarrhea. Some claim that the diarrhea during withdrawal is so extreme, that failure to administer an antidiarrheal agent (e.g. Imodium) could lead to an embarrassing intra-pants disaster. For a majority of former kratom users, the diarrhea that emerges during withdrawal is most severe within the first few weeks of cessation and slowly subsides thereafter. It is thought that diarrhea is results from numerous physiologic adaptations to kratom that remain after its discontinuation, including: upregulation of peripheral mu-opioid receptors, enhanced noradrenergic firing and sympathetic tone, and possibly changes in gut microbiota. If you’re experiencing severe diarrhea after kratom discontinuation, it is recommended to utilize a safe and effective antidiarrheal agent. In conjunction with an antidiarrheal agent, it is recommended to stay hydrated, maintain electrolyte balance, avoid excessive fiber, and eat specific foods that won’t exacerbate diarrhea (e.g. bananas, rice, applesauce, toast). Some individuals claim that supplementation with probiotics is also helpful to ameliorate the diarrhea. Know that with adequate duration kratom-free, your gastrointestinal function will return to homeostasis and the diarrhea will subside.

: Another extremely common kratom withdrawal symptom that you may experience is diarrhea. Some claim that the diarrhea during withdrawal is so extreme, that failure to administer an antidiarrheal agent (e.g. Imodium) could lead to an embarrassing intra-pants disaster. For a majority of former kratom users, the diarrhea that emerges during withdrawal is most severe within the first few weeks of cessation and slowly subsides thereafter. It is thought that diarrhea is results from numerous physiologic adaptations to kratom that remain after its discontinuation, including: upregulation of peripheral mu-opioid receptors, enhanced noradrenergic firing and sympathetic tone, and possibly changes in gut microbiota. If you’re experiencing severe diarrhea after kratom discontinuation, it is recommended to utilize a safe and effective antidiarrheal agent. In conjunction with an antidiarrheal agent, it is recommended to stay hydrated, maintain electrolyte balance, avoid excessive fiber, and eat specific foods that won’t exacerbate diarrhea (e.g. bananas, rice, applesauce, toast). Some individuals claim that supplementation with probiotics is also helpful to ameliorate the diarrhea. Know that with adequate duration kratom-free, your gastrointestinal function will return to homeostasis and the diarrhea will subside. Dizziness : Among the most common of kratom withdrawal symptoms is dizziness. If you feel extremely dizzy, as if your equilibrium is imbalanced or your head is spinning after kratom cessation, understand that this is fairly normal. In most cases, the withdrawal-related dizziness is most severe among persons who discontinue kratom usage too abruptly after a long-term. While the severity of withdrawal-related dizziness usually diminishes within a month of discontinuation, low-grade (i.e. mild) dizziness may linger for months after your final dose. There are many potential causes of dizziness in withdrawal, including: changes in vestibular apparatus activation, blood pressure fluctuations, neurochemical adjustments, and sympathetic overactivation. Perhaps the most effective way to avoid excessive dizziness during kratom withdrawal is to conduct an extremely slow taper (e.g. 10% per month). Some claim that certain supplements and/or over-the-counter medications for motion sickness (e.g. Dramamine) improve their dizziness. If your dizziness is severe, it is recommended to avoid operating a motor vehicle and/or heavy machinery due to the fact that you may be more likely to injure yourself and/or others.

: Among the most common of kratom withdrawal symptoms is dizziness. If you feel extremely dizzy, as if your equilibrium is imbalanced or your head is spinning after kratom cessation, understand that this is fairly normal. In most cases, the withdrawal-related dizziness is most severe among persons who discontinue kratom usage too abruptly after a long-term. While the severity of withdrawal-related dizziness usually diminishes within a month of discontinuation, low-grade (i.e. mild) dizziness may linger for months after your final dose. There are many potential causes of dizziness in withdrawal, including: changes in vestibular apparatus activation, blood pressure fluctuations, neurochemical adjustments, and sympathetic overactivation. Perhaps the most effective way to avoid excessive dizziness during kratom withdrawal is to conduct an extremely slow taper (e.g. 10% per month). Some claim that certain supplements and/or over-the-counter medications for motion sickness (e.g. Dramamine) improve their dizziness. If your dizziness is severe, it is recommended to avoid operating a motor vehicle and/or heavy machinery due to the fact that you may be more likely to injure yourself and/or others. Fatigue : Don’t be surprised if, at some point during kratom withdrawal, you feel extremely fatigued. Certain individuals have reported feeling so fatigued that it seems nearly impossible to maintain personal health and hygiene (e.g. cooking, showering, getting dressed) or perform necessary household chores (e.g. cleaning dishes, vacuuming, making the bed, etc.). If your fatigue is overwhelming, you may want to take a week or two off from work until energy returns. There are many possible causes of withdrawal-related fatigue, including: irregular neurotransmission, atypical hormone secretion, and/or the effort of your CNS to transition back to pre-kratom homeostasis. The fatigue may not be identical in withdrawal among all kratom users due to the fact that not all types of kratom exert the same effect. Hypothetically, a person who’s physiologically adapted to Red Vein Maeng Da may experience fatigue from excessive sympathetic activation [and corresponding anxiety] during withdrawal, whereas someone adapted to White Vein Thai may experience fatigue from lack of sympathetic activation [and corresponding depression] during withdrawal. In most cases, energy levels significantly increase within a few weeks of kratom discontinuation, however, it may take several months for energy to fully recover. Engaging in mild physical activity, eating a healthy diet, and using certain dietary supplements and/or prescription medications may prove useful for attenuating withdrawal-related fatigue.

: Don’t be surprised if, at some point during kratom withdrawal, you feel extremely fatigued. Certain individuals have reported feeling so fatigued that it seems nearly impossible to maintain personal health and hygiene (e.g. cooking, showering, getting dressed) or perform necessary household chores (e.g. cleaning dishes, vacuuming, making the bed, etc.). If your fatigue is overwhelming, you may want to take a week or two off from work until energy returns. There are many possible causes of withdrawal-related fatigue, including: irregular neurotransmission, atypical hormone secretion, and/or the effort of your CNS to transition back to pre-kratom homeostasis. The fatigue may not be identical in withdrawal among all kratom users due to the fact that not all types of kratom exert the same effect. Hypothetically, a person who’s physiologically adapted to Red Vein Maeng Da may experience fatigue from excessive sympathetic activation [and corresponding anxiety] during withdrawal, whereas someone adapted to White Vein Thai may experience fatigue from lack of sympathetic activation [and corresponding depression] during withdrawal. In most cases, energy levels significantly increase within a few weeks of kratom discontinuation, however, it may take several months for energy to fully recover. Engaging in mild physical activity, eating a healthy diet, and using certain dietary supplements and/or prescription medications may prove useful for attenuating withdrawal-related fatigue. Flu-like symptoms : Withdrawal from any opioidergic drug, including kratom, tends to yield flu-like symptoms such as: chills, fatigue, headaches, muscle aches, and runny nose. Individuals who have used kratom regularly over a long-term who discontinue abruptly [without tapering] will likely experience the most severe flu-like symptoms. For some individuals, the flu-like symptoms that emerge during kratom withdrawal may seem just as wicked (perhaps even more so) than the actual flu. Coping with flu-like symptoms of kratom withdrawal generally involves utilizing over-the-counter medications, eating foods that won’t irritate the GI tract, and getting extra rest. Analogous to detoxification from opiates/opioids, flu-like symptoms that emerge kratom withdrawal tend to be most severe within the first 3 to 7 days of discontinuation.

: Withdrawal from any opioidergic drug, including kratom, tends to yield flu-like symptoms such as: chills, fatigue, headaches, muscle aches, and runny nose. Individuals who have used kratom regularly over a long-term who discontinue abruptly [without tapering] will likely experience the most severe flu-like symptoms. For some individuals, the flu-like symptoms that emerge during kratom withdrawal may seem just as wicked (perhaps even more so) than the actual flu. Coping with flu-like symptoms of kratom withdrawal generally involves utilizing over-the-counter medications, eating foods that won’t irritate the GI tract, and getting extra rest. Analogous to detoxification from opiates/opioids, flu-like symptoms that emerge kratom withdrawal tend to be most severe within the first 3 to 7 days of discontinuation. Frequent urination : Kratom is known to cause urinary incontinence (retention) as a side effect, yet during withdrawal, many individuals experience the opposite whereby they urinate frequently. Some have claimed that the frequent urination interferes with their sleep and productivity at work because they end up running to the bathroom every 20 minutes. Although frequent urination will eventually subside, it may be highly frustrating to manage in the first month of withdrawal. To cope with increased urinary frequency (and diarrhea), some former kratom users have jokingly suggested wearing an adult diaper. The cause of frequent urination during kratom withdrawal is likely partly due to sustained noradrenergic signaling and sympathetic activation. When the sympathetic nervous system is overactive compared to the parasympathetic, muscle tension occurs which can put additional pressure on your bladder whereby you secrete more urine. It’s also thought that the freeze-fight-flight response directly induces urinary secretion as an evolutionary adaptation. Moreover, during withdrawal, your body may process fluids and/or nutrients differently than usual such that water passes through your body quicker and you urinate more often. To manage frequent urination in withdrawal, it may be helpful to practice relaxation regularly (e.g. twice per day) and/or consult a doctor about temporary pharmacological interventions. If you are urinating frequently, ensure that you’re replenishing electrolytes and staying hydrated – while avoiding overhydration.

: Kratom is known to cause urinary incontinence (retention) as a side effect, yet during withdrawal, many individuals experience the opposite whereby they urinate frequently. Some have claimed that the frequent urination interferes with their sleep and productivity at work because they end up running to the bathroom every 20 minutes. Although frequent urination will eventually subside, it may be highly frustrating to manage in the first month of withdrawal. To cope with increased urinary frequency (and diarrhea), some former kratom users have jokingly suggested wearing an adult diaper. The cause of frequent urination during kratom withdrawal is likely partly due to sustained noradrenergic signaling and sympathetic activation. When the sympathetic nervous system is overactive compared to the parasympathetic, muscle tension occurs which can put additional pressure on your bladder whereby you secrete more urine. It’s also thought that the freeze-fight-flight response directly induces urinary secretion as an evolutionary adaptation. Moreover, during withdrawal, your body may process fluids and/or nutrients differently than usual such that water passes through your body quicker and you urinate more often. To manage frequent urination in withdrawal, it may be helpful to practice relaxation regularly (e.g. twice per day) and/or consult a doctor about temporary pharmacological interventions. If you are urinating frequently, ensure that you’re replenishing electrolytes and staying hydrated – while avoiding overhydration. Headaches or Migraines : Another extremely common kratom withdrawal symptom is headache or migraine. Headaches are usually caused by intracranial blood vessel constriction, whereas migraines are typically caused by intracranial blood vessel dilation. Your specific neurochemistry, as well as the type of kratom you were using may influence whether you’re more susceptible to headache or migraine during withdrawal. That said, it is thought that severe headaches in withdrawal may be related to overactivation of the sympathetic nervous system and excessive norepinephrine signaling. Though an over-the-counter medication for headaches may prove useful, in some cases it may be more effective to engage in relaxation exercises and/or administer supplements that facilitate parasympathetic upregulation to balance autonomic activity. If you’re experiencing migraine, talk to your doctor about prophylactic strategies and/or abortive options. Decreasing oxidative stress with specific supplemental antioxidants could prove useful at preventing certain types of headache/migraine as well. Since headaches and migraines can be caused by dehydration and/or electrolyte imbalances, you’ll want to ensure that you’re staying hydrated and maintaining adequate electrolyte intake.

: Another extremely common kratom withdrawal symptom is headache or migraine. Headaches are usually caused by intracranial blood vessel constriction, whereas migraines are typically caused by intracranial blood vessel dilation. Your specific neurochemistry, as well as the type of kratom you were using may influence whether you’re more susceptible to headache or migraine during withdrawal. That said, it is thought that severe headaches in withdrawal may be related to overactivation of the sympathetic nervous system and excessive norepinephrine signaling. Though an over-the-counter medication for headaches may prove useful, in some cases it may be more effective to engage in relaxation exercises and/or administer supplements that facilitate parasympathetic upregulation to balance autonomic activity. If you’re experiencing migraine, talk to your doctor about prophylactic strategies and/or abortive options. Decreasing oxidative stress with specific supplemental antioxidants could prove useful at preventing certain types of headache/migraine as well. Since headaches and migraines can be caused by dehydration and/or electrolyte imbalances, you’ll want to ensure that you’re staying hydrated and maintaining adequate electrolyte intake. Hot flashes : Hot flashes, or sudden (usually unexpected) surges of feverish heat, are also fairly typical during kratom withdrawal. In many cases, the hot flashes that occur throughout kratom withdrawal may be accompanied by increased sweating, flushing or redness of the skin, and/or paresthesia (tingling of the skin). A combination of changes in neurotransmitter signaling, hormone levels, and/or activation of brain regions implicated in thermoregulation – all of which are exhibited during withdrawal – might be culpable for hot flashes. Some individuals will experience a combination of hot flashes and cold flashes such that bursts of feverish heat occur one day, then surges of coldness emerge another. If you’re noticing hot flashes (or cold flashes), it’s possible that your thermoregulatory systems are attempting to normalize post-kratom. With enough time kratom-free, the flashes of warmth and/or other temperature fluctuations should subside. To reduce likelihood of hot flashes, it is recommended to avoid alcohol, caffeine, smoking, and spicy foods – each of which can trigger and/or exacerbate them. Furthermore, some find it helpful to minimize stress, wear loose and/or baggy clothing, and/or utilize an icepack or sip ice water when the flashes occur.

: Hot flashes, or sudden (usually unexpected) surges of feverish heat, are also fairly typical during kratom withdrawal. In many cases, the hot flashes that occur throughout kratom withdrawal may be accompanied by increased sweating, flushing or redness of the skin, and/or paresthesia (tingling of the skin). A combination of changes in neurotransmitter signaling, hormone levels, and/or activation of brain regions implicated in thermoregulation – all of which are exhibited during withdrawal – might be culpable for hot flashes. Some individuals will experience a combination of hot flashes and cold flashes such that bursts of feverish heat occur one day, then surges of coldness emerge another. If you’re noticing hot flashes (or cold flashes), it’s possible that your thermoregulatory systems are attempting to normalize post-kratom. With enough time kratom-free, the flashes of warmth and/or other temperature fluctuations should subside. To reduce likelihood of hot flashes, it is recommended to avoid alcohol, caffeine, smoking, and spicy foods – each of which can trigger and/or exacerbate them. Furthermore, some find it helpful to minimize stress, wear loose and/or baggy clothing, and/or utilize an icepack or sip ice water when the flashes occur. Increased blood pressure : While withdrawing from kratom, you may want to monitor your blood pressure for spikes and/or increases. If you were using kratom at a high-dose for an extended-term, chances are that your physiology adapted to its CNS depressant effect. As part of this adaptation noradrenergic signaling likely increased, and after kratom cessation, it will likely remain increased. The sustained increase of noradrenergic signaling coupled with lack of kratom-induced CNS depression may yield excessive sympathetic activation and corresponding high blood pressure. In vulnerable populations, spikes in blood pressure following kratom cessation could lead to serious medical complications such as: aneurysm, cognitive deficits, heart attack or failure, stroke, and/or torn blood vessels. Should you notice irregular blood pressure during kratom withdrawal, seek immediate medical attention. Fortunately, most withdrawal-related blood pressure spikes tend to diminish within a few weeks.

: While withdrawing from kratom, you may want to monitor your blood pressure for spikes and/or increases. If you were using kratom at a high-dose for an extended-term, chances are that your physiology adapted to its CNS depressant effect. As part of this adaptation noradrenergic signaling likely increased, and after kratom cessation, it will likely remain increased. The sustained increase of noradrenergic signaling coupled with lack of kratom-induced CNS depression may yield excessive sympathetic activation and corresponding high blood pressure. In vulnerable populations, spikes in blood pressure following kratom cessation could lead to serious medical complications such as: aneurysm, cognitive deficits, heart attack or failure, stroke, and/or torn blood vessels. Should you notice irregular blood pressure during kratom withdrawal, seek immediate medical attention. Fortunately, most withdrawal-related blood pressure spikes tend to diminish within a few weeks. Insomnia : During kratom withdrawal, some individuals will swing between bouts of excessive sleep and insomnia. For example, a high-dose and/or long-term kratom user may abruptly discontinue administration and sleep excessively the first few days, but find it impossible to sleep in subsequent days or weeks. As a withdrawal symptom, insomnia may be highly frustrating in that it might cause other circadian and/or sleep disturbances, each of which could alter physiology to exacerbate unwanted withdrawal symptoms (e.g. cognitive deficits). Excessive noradrenergic activity and/or lack of inhibitory transmission are likely causally implicated in withdrawal-related insomnia. Furthermore, it’s possible that specific withdrawal symptoms such as agitation, diarrhea, frequent urination, heart palpitations, restless legs – directly induce insomnia in certain individuals. While some insomnia should be expected during withdrawal, some interventions may attenuate its severity, including: daytime sunlight exposure, mild exercise in the morning, avoidance of blue light in the evening, maintaining a dark room or using a sleep mask, relaxation exercises, dietary supplements, and/or prescription sleeping pills.

: During kratom withdrawal, some individuals will swing between bouts of excessive sleep and insomnia. For example, a high-dose and/or long-term kratom user may abruptly discontinue administration and sleep excessively the first few days, but find it impossible to sleep in subsequent days or weeks. As a withdrawal symptom, insomnia may be highly frustrating in that it might cause other circadian and/or sleep disturbances, each of which could alter physiology to exacerbate unwanted withdrawal symptoms (e.g. cognitive deficits). Excessive noradrenergic activity and/or lack of inhibitory transmission are likely causally implicated in withdrawal-related insomnia. Furthermore, it’s possible that specific withdrawal symptoms such as agitation, diarrhea, frequent urination, heart palpitations, restless legs – directly induce insomnia in certain individuals. While some insomnia should be expected during withdrawal, some interventions may attenuate its severity, including: daytime sunlight exposure, mild exercise in the morning, avoidance of blue light in the evening, maintaining a dark room or using a sleep mask, relaxation exercises, dietary supplements, and/or prescription sleeping pills. Irritability : A kratom withdrawal symptom that goes hand-in-hand with anxiety, agitation, anger, aggression, and depression – is irritability. At some point during withdrawal, you may find it difficult to control your emotions in social situations and/or around others. Every little action, behavior, or conversation may make you irritable or incite frustration. While experiencing the irritability, it may seem as though it’s never going to improve – or as if you’re doomed to a life of being irritable. What’s likely is that your neurochemistry adjusted itself to receiving the peaceful, serenic effect induced by kratom, and upon discontinuation of kratom, you experience the opposite such that you’re highly irritable. In the event that the irritability is overwhelming, you may want to consider seeking the help of a psychologist for CBT and/or a psychiatrist for pharmacological interventions. Assuming you don’t have an exceptionally irritable homeostatic demeanor, it’s likely that – with adequate sleep, proper nutrition, daily relaxation, exercise, and enough time – the irritability will eventually wane.

: A kratom withdrawal symptom that goes hand-in-hand with anxiety, agitation, anger, aggression, and depression – is irritability. At some point during withdrawal, you may find it difficult to control your emotions in social situations and/or around others. Every little action, behavior, or conversation may make you irritable or incite frustration. While experiencing the irritability, it may seem as though it’s never going to improve – or as if you’re doomed to a life of being irritable. What’s likely is that your neurochemistry adjusted itself to receiving the peaceful, serenic effect induced by kratom, and upon discontinuation of kratom, you experience the opposite such that you’re highly irritable. In the event that the irritability is overwhelming, you may want to consider seeking the help of a psychologist for CBT and/or a psychiatrist for pharmacological interventions. Assuming you don’t have an exceptionally irritable homeostatic demeanor, it’s likely that – with adequate sleep, proper nutrition, daily relaxation, exercise, and enough time – the irritability will eventually wane. Itching : Interestingly, kratom can cause itching as a side effect and a withdrawal symptom. The itching that occurs while under the influence of kratom is associated with central activation of mu-opioid receptor (1D) which transmits signaling of itch sensations via the spinal cord. It’s also thought that activation of other opioid receptors and histamine release while using kratom can cause itching. The itchiness that emerges during withdrawal may be a byproduct of abrupt changes in central and peripheral opioid receptor activation, and potentially from altered histaminergic signaling. It’s also possible that individuals may exhibit shifts in peripheral blood flow during withdrawal that are conducive to itching. In the event that you’re excessively itchy during kratom detox and are constantly clawing your skin, you may want to inquire a doctor about some useful anti-itch interventions.

: Interestingly, kratom can cause itching as a side effect and a withdrawal symptom. The itching that occurs while under the influence of kratom is associated with central activation of mu-opioid receptor (1D) which transmits signaling of itch sensations via the spinal cord. It’s also thought that activation of other opioid receptors and histamine release while using kratom can cause itching. The itchiness that emerges during withdrawal may be a byproduct of abrupt changes in central and peripheral opioid receptor activation, and potentially from altered histaminergic signaling. It’s also possible that individuals may exhibit shifts in peripheral blood flow during withdrawal that are conducive to itching. In the event that you’re excessively itchy during kratom detox and are constantly clawing your skin, you may want to inquire a doctor about some useful anti-itch interventions. Jitteriness : Within a week or two of kicking kratom, you might exhibit the jitters or extreme nervousness accompanied by shakiness, tremor, or unsteadiness. Some researchers believe that jitters occurring in withdrawal stem from excessive release of norepinephrine within the locus coeruleus to activate the sympathetic nervous system. Withdrawal-related may be exacerbated by unmanaged anxiety and/or environmental stressors, but may be attenuated with relaxation techniques, a bit of exercise, and/or sedative substances. Though the jitters can be somewhat disconcerting, they are usually not a big deal compared to most other withdrawal symptoms.

: Within a week or two of kicking kratom, you might exhibit the jitters or extreme nervousness accompanied by shakiness, tremor, or unsteadiness. Some researchers believe that jitters occurring in withdrawal stem from excessive release of norepinephrine within the locus coeruleus to activate the sympathetic nervous system. Withdrawal-related may be exacerbated by unmanaged anxiety and/or environmental stressors, but may be attenuated with relaxation techniques, a bit of exercise, and/or sedative substances. Though the jitters can be somewhat disconcerting, they are usually not a big deal compared to most other withdrawal symptoms. Lack of motivation : Even if kratom didn’t boost your motivation while under its influence, you may notice that your motivation takes a significant hit during withdrawal. Motivation is largely a byproduct of regional brain activity, neurotransmission, and autonomic activation. When certain regions of the brain are underactive and/or neurotransmitter signaling decreases, we feel less motivated. Similarly, if the autonomic nervous system is dysregulated such that we’re overly stressed due to excessive sympathetic activity – it may be challenging to summon up motivation. During kratom withdrawal, a person’s brain activity, neurotransmission, and autonomic nervous system activity can be considered abnormal, and culpable for low motivation. With concerted recovery efforts and enough time, physiology should revert back to pre-kratom homeostasis and motivation will return.

: Even if kratom didn’t boost your motivation while under its influence, you may notice that your motivation takes a significant hit during withdrawal. Motivation is largely a byproduct of regional brain activity, neurotransmission, and autonomic activation. When certain regions of the brain are underactive and/or neurotransmitter signaling decreases, we feel less motivated. Similarly, if the autonomic nervous system is dysregulated such that we’re overly stressed due to excessive sympathetic activity – it may be challenging to summon up motivation. During kratom withdrawal, a person’s brain activity, neurotransmission, and autonomic nervous system activity can be considered abnormal, and culpable for low motivation. With concerted recovery efforts and enough time, physiology should revert back to pre-kratom homeostasis and motivation will return. Memory impairment : Anyone that’s used a high-dose of kratom likely has exhibited some degree of memory impairment. High doses of kratom induce CNS depression whereby alertness declines and it becomes more challenging to store and retrieve memories. That said, during kratom withdrawal individuals may experience equally severe (or potentially more severe) memory impairment as they did while under kratom’s influence. During withdrawal, neurochemistry is generally aberrant and aspects of cognition, particularly memory, are detrimentally affected. Assuming you didn’t use kratom in excess for an extended period of time, your memory is likely to make a full recovery with enough time kratom-free.

: Anyone that’s used a high-dose of kratom likely has exhibited some degree of memory impairment. High doses of kratom induce CNS depression whereby alertness declines and it becomes more challenging to store and retrieve memories. That said, during kratom withdrawal individuals may experience equally severe (or potentially more severe) memory impairment as they did while under kratom’s influence. During withdrawal, neurochemistry is generally aberrant and aspects of cognition, particularly memory, are detrimentally affected. Assuming you didn’t use kratom in excess for an extended period of time, your memory is likely to make a full recovery with enough time kratom-free. Muscle aches, pains, tension : After an extended-term of regular kratom usage followed by discontinuation, individuals commonly experience muscle aches, muscle pains, and/or muscle tension. Persons with pain conditions prior to taking kratom may notice that the severity of pain during withdrawal is much greater than the severity prior to using kratom. This might be due to the fact that the body’s ability to provide endogenous pain relief is downregulated as an adaptation to long-term kratom administration. As a result, when kratom is discontinued, not only is there no analgesic effect generated by kratom, but the body is less equipped to facilitate endogenous pain relief – leading to substantial muscle pain. It’s also likely that excessive excitatory transmission in the CNS and PNS induce sympathetic overactivation to increase muscle tension, which can cause aches and pains. It may be helpful to use an over-the-counter pain medication and/or ask your doctor about pain relief during kratom withdrawal. Potentially useful strategies to mitigate withdrawal-related muscle aches, pains, and tension includes: hot baths (possibly with Epsom salts), saunas, hot showers, or basking in the sun. Various dietary supplements, medications, and essential oils for anxiety may also decrease muscle tension.

: After an extended-term of regular kratom usage followed by discontinuation, individuals commonly experience muscle aches, muscle pains, and/or muscle tension. Persons with pain conditions prior to taking kratom may notice that the severity of pain during withdrawal is much greater than the severity prior to using kratom. This might be due to the fact that the body’s ability to provide endogenous pain relief is downregulated as an adaptation to long-term kratom administration. As a result, when kratom is discontinued, not only is there no analgesic effect generated by kratom, but the body is less equipped to facilitate endogenous pain relief – leading to substantial muscle pain. It’s also likely that excessive excitatory transmission in the CNS and PNS induce sympathetic overactivation to increase muscle tension, which can cause aches and pains. It may be helpful to use an over-the-counter pain medication and/or ask your doctor about pain relief during kratom withdrawal. Potentially useful strategies to mitigate withdrawal-related muscle aches, pains, and tension includes: hot baths (possibly with Epsom salts), saunas, hot showers, or basking in the sun. Various dietary supplements, medications, and essential oils for anxiety may also decrease muscle tension. Nausea : In the first week of taking kratom, you may have experienced some nausea from its activation of mu-opioid receptors located within chemoreceptor trigger zone (CTZ) of the brain. The chemoreceptor trigger zone induces emetic effects such as nausea and vomiting. Eventually, most individuals continue taking kratom regularly, the nausea that once occurred subsides. However, the nausea may return with a vengeance during the acute stages of kratom withdrawal, especially within the first couple weeks. In some cases, the withdrawal-related nausea will be so severe that it leads to vomiting. It’s possible that nausea is due to altered activity once again in the chemoreceptor trigger zone. It’s also possible that the nausea is related to changes in gastrointestinal function that occur following kratom cessation and/or that it stems from particularly severe withdrawal symptoms (e.g. anxiety). If you’re experiencing nausea, you may find it helpful to administer an antiemetic. Avoiding foods that cause gastric distress, staying hydrated, and simply lying down to rest can often help nausea.

: In the first week of taking kratom, you may have experienced some nausea from its activation of mu-opioid receptors located within chemoreceptor trigger zone (CTZ) of the brain. The chemoreceptor trigger zone induces emetic effects such as nausea and vomiting. Eventually, most individuals continue taking kratom regularly, the nausea that once occurred subsides. However, the nausea may return with a vengeance during the acute stages of kratom withdrawal, especially within the first couple weeks. In some cases, the withdrawal-related nausea will be so severe that it leads to vomiting. It’s possible that nausea is due to altered activity once again in the chemoreceptor trigger zone. It’s also possible that the nausea is related to changes in gastrointestinal function that occur following kratom cessation and/or that it stems from particularly severe withdrawal symptoms (e.g. anxiety). If you’re experiencing nausea, you may find it helpful to administer an antiemetic. Avoiding foods that cause gastric distress, staying hydrated, and simply lying down to rest can often help nausea. Palpitations : If you sense that your heart is fluttering, skipping a beat, and/or perceive that your heart is beating with intense force – you may be experiencing palpitations from kratom withdrawal. Heart palpitations are thought to occur due to the fact that, over an extended duration of kratom administration, noradrenergic signaling increases in the locus coeruleus to offset excessive CNS depression. When a person ceases kratom intake, the increased noradrenergic signaling remains, but there’s no longer a depressant effect facilitated by kratom. As a result, individuals end up with an overactive sympathetic branch of the autonomic nervous system whereby they experience predictable physical manifestations such as palpitations. If you’ve never experienced palpitations before, they can induce anxiety, leading to a vicious circle in which palpitations cause anxiety and anxiety causes palpitations. To cope with palpitations, it is often helpful to accept them and welcome them when they arrive, knowing they are nothing more than a withdrawal symptom that will eventually cease. It may also help to engage in some sort of psychological relaxation (e.g. deep breathing) to upregulate parasympathetic tone. All that said, if you’ve ever been diagnosed with a heart condition or hypertension, consult a cardiologist to ensure normative cardiac function during withdrawal.

: If you sense that your heart is fluttering, skipping a beat, and/or perceive that your heart is beating with intense force – you may be experiencing palpitations from kratom withdrawal. Heart palpitations are thought to occur due to the fact that, over an extended duration of kratom administration, noradrenergic signaling increases in the locus coeruleus to offset excessive CNS depression. When a person ceases kratom intake, the increased noradrenergic signaling remains, but there’s no longer a depressant effect facilitated by kratom. As a result, individuals end up with an overactive sympathetic branch of the autonomic nervous system whereby they experience predictable physical manifestations such as palpitations. If you’ve never experienced palpitations before, they can induce anxiety, leading to a vicious circle in which palpitations cause anxiety and anxiety causes palpitations. To cope with palpitations, it is often helpful to accept them and welcome them when they arrive, knowing they are nothing more than a withdrawal symptom that will eventually cease. It may also help to engage in some sort of psychological relaxation (e.g. deep breathing) to upregulate parasympathetic tone. All that said, if you’ve ever been diagnosed with a heart condition or hypertension, consult a cardiologist to ensure normative cardiac function during withdrawal. Restless legs : If you’ve used kratom for a long-term and/or at high doses, there’s a good chance you may experience “restless leg” as a symptom of withdrawal. Restless leg is characterized by an irresistible urge to move the legs and is often most severe in the late afternoon or evening. Many report that restless leg that emerges during kratom discontinuation is most debilitating just before falling asleep, ultimately leading to insomnia. Some claim that restless leg actually wakes them up from a sound sleep in the middle of the night such that it interferes with sleep quality and duration. Although the cause of restless leg during kratom withdrawal isn’t fully known, it likely results from irregular central and peripheral chemical signaling. Assuming you weren’t formally diagnosed with restless leg syndrome (RLS) prior to taking kratom, the restless leg should eventually cease with adequate duration of kratom abstinence. If you’re struggling to cope with withdrawal-related restless leg, strategies that may prove useful include: physical activity or pressure (e.g. walking, moving, massaging, stretching, etc.) and/or mental stimulation (e.g. playing a video game, solving a puzzle, etc.). It is also recommended to avoid caffeine, nicotine, and alcohol – as each of these can exacerbate restless leg. Keep in mind that some medications you may be using to curb kratom withdrawal symptoms such as antihistamines, antiemetic agents, antidepressants, and neuroleptics – can each provoke restless leg. In severe cases of restless leg, medical professionals may prescribe a benzodiazepine or dopamine agonist – both of which may attenuate the restlessness.

: If you’ve used kratom for a long-term and/or at high doses, there’s a good chance you may experience “restless leg” as a symptom of withdrawal. Restless leg is characterized by an irresistible urge to move the legs and is often most severe in the late afternoon or evening. Many report that restless leg that emerges during kratom discontinuation is most debilitating just before falling asleep, ultimately leading to insomnia. Some claim that restless leg actually wakes them up from a sound sleep in the middle of the night such that it interferes with sleep quality and duration. Although the cause of restless leg during kratom withdrawal isn’t fully known, it likely results from irregular central and peripheral chemical signaling. Assuming you weren’t formally diagnosed with restless leg syndrome (RLS) prior to taking kratom, the restless leg should eventually cease with adequate duration of kratom abstinence. If you’re struggling to cope with withdrawal-related restless leg, strategies that may prove useful include: physical activity or pressure (e.g. walking, moving, massaging, stretching, etc.) and/or mental stimulation (e.g. playing a video game, solving a puzzle, etc.). It is also recommended to avoid caffeine, nicotine, and alcohol – as each of these can exacerbate restless leg. Keep in mind that some medications you may be using to curb kratom withdrawal symptoms such as antihistamines, antiemetic agents, antidepressants, and neuroleptics – can each provoke restless leg. In severe cases of restless leg, medical professionals may prescribe a benzodiazepine or dopamine agonist – both of which may attenuate the restlessness. Restlessness : In addition to restless leg, many individuals exhibit a general sense of restlessness after ceasing kratom in which the entire body is restless – not just the legs. The restlessness that occurs post-cessation may be associated with symptoms of anxiety, agitation, and irritability – and may stem from overactivation of the sympathetic nervous system. It’s also possible that the restlessness may be related to transiently low dopamine signaling in certain areas of the brain. With enough time kratom-free, sympathetic tone should diminish and dopamine signaling should increase, each of which may counteract restless tendencies. To manage restlessness, it is recommended to stay physically active and take some time for psychological relaxation each day. If you find the restlessness unbearable to the extent that it’s interfering with your career and/or studies – consult a medical professional about possible [temporary] treatments.

: In addition to restless leg, many individuals exhibit a general sense of restlessness after ceasing kratom in which the entire body is restless – not just the legs. The restlessness that occurs post-cessation may be associated with symptoms of anxiety, agitation, and irritability – and may stem from overactivation of the sympathetic nervous system. It’s also possible that the restlessness may be related to transiently low dopamine signaling in certain areas of the brain. With enough time kratom-free, sympathetic tone should diminish and dopamine signaling should increase, each of which may counteract restless tendencies. To manage restlessness, it is recommended to stay physically active and take some time for psychological relaxation each day. If you find the restlessness unbearable to the extent that it’s interfering with your career and/or studies – consult a medical professional about possible [temporary] treatments. Runny nose : Some individuals will notice rhinorrhea or an exceptionally runny nose when they stop using kratom. In fact, certain persons have claimed that a runny nose is among the very first withdrawal symptoms noticed. There are many lay hypotheses regarding the causes of runny nose during kratom withdrawal, including: altered immune function, changes in histamine secretion, and/or adaptations of mucous membranes. Perhaps the most likely the cause of runny nose during kratom withdrawal is intranasal vasodilation. Thankfully, in most cases, the severity of runny nose in kratom withdrawal tends to peak within the first several days of discontinuation and subsides within 1-2 weeks. It has been suggested that nasal sprays, physical exercise, and over-the-counter medications could be helpful for rhinorrhea in kratom withdrawal.

: Some individuals will notice rhinorrhea or an exceptionally runny nose when they stop using kratom. In fact, certain persons have claimed that a runny nose is among the very first withdrawal symptoms noticed. There are many lay hypotheses regarding the causes of runny nose during kratom withdrawal, including: altered immune function, changes in histamine secretion, and/or adaptations of mucous membranes. Perhaps the most likely the cause of runny nose during kratom withdrawal is intranasal vasodilation. Thankfully, in most cases, the severity of runny nose in kratom withdrawal tends to peak within the first several days of discontinuation and subsides within 1-2 weeks. It has been suggested that nasal sprays, physical exercise, and over-the-counter medications could be helpful for rhinorrhea in kratom withdrawal. Sleep problems : It is common to experience major sleep problems when quitting kratom after a long-term. Examples of withdrawal-related sleep problems include: insomnia, frequently waking throughout the night, excessive tossing-and-turning, and/or upsetting dreams (e.g. nightmares). Most individuals will find that their sleep quality is poor and their sleep quantity is reduced at various stages of kratom withdrawal. In some cases, it may be difficult to maintain a normative sleep schedule, leaving you groggy and/or tired during the daytime and abnormally restless at night. The cause(s) of sleep problems during kratom withdrawal may include things like: neurochemical and/or hormone imbalances, circadian rhythm dysfunction, and/or specific withdrawal symptoms (e.g. restless leg, palpitations, etc.). As physiology readjusts itself from kratom-adapted to homeostasis, sleep will normalize. That said, it helps to make a concerted effort to get your sleep back on track. Possibly useful strategies for doing so may include: adhering to a strict sleep schedule (for bedtime and waking); avoiding electronics / blue light at night; avoiding sleep-disrupting substances (e.g. caffeine, nicotine, alcohol); get plenty of sunlight in the morning and afternoon (to optimize your circadian rhythm); exercise early in the day; and engage in relaxation to minimize sympathetic tone (e.g. deep breathing) before bed. It may also prove beneficial to ask your doctor about supplements and/or medications that you could use to ameliorate withdrawal-related sleep disturbances.

: It is common to experience major sleep problems when quitting kratom after a long-term. Examples of withdrawal-related sleep problems include: insomnia, frequently waking throughout the night, excessive tossing-and-turning, and/or upsetting dreams (e.g. nightmares). Most individuals will find that their sleep quality is poor and their sleep quantity is reduced at various stages of kratom withdrawal. In some cases, it may be difficult to maintain a normative sleep schedule, leaving you groggy and/or tired during the daytime and abnormally restless at night. The cause(s) of sleep problems during kratom withdrawal may include things like: neurochemical and/or hormone imbalances, circadian rhythm dysfunction, and/or specific withdrawal symptoms (e.g. restless leg, palpitations, etc.). As physiology readjusts itself from kratom-adapted to homeostasis, sleep will normalize. That said, it helps to make a concerted effort to get your sleep back on track. Possibly useful strategies for doing so may include: adhering to a strict sleep schedule (for bedtime and waking); avoiding electronics / blue light at night; avoiding sleep-disrupting substances (e.g. caffeine, nicotine, alcohol); get plenty of sunlight in the morning and afternoon (to optimize your circadian rhythm); exercise early in the day; and engage in relaxation to minimize sympathetic tone (e.g. deep breathing) before bed. It may also prove beneficial to ask your doctor about supplements and/or medications that you could use to ameliorate withdrawal-related sleep disturbances. Sneezing : Another physiologic reaction to kratom withdrawal is increased sneezing. It is known that sneezes are generally an adaptive semi-autonomic response intended to rid the nasal mucosa of irritating particles. Some research suggests that sneezing is linked to bright light exposure, sudden drops in temperature, and/or gastrointestinal function. During kratom withdrawal, it may be that thermoregulatory, gastrointestinal, and/or neurochemical reduce the threshold for a sneeze reflex whereby sneezes occur with increased frequency during withdrawal. Avoidance of cold temperatures, minimizing exposure to [indoor and/or outdoor] air pollution with a purifier, and maintaining adequate humidity may reduce sneeze in withdrawal. Perhaps intranasal blood vessel dilation associated with rhinorrhea also [directly or indirectly] leads to sneezing.

: Another physiologic reaction to kratom withdrawal is increased sneezing. It is known that sneezes are generally an adaptive semi-autonomic response intended to rid the nasal mucosa of irritating particles. Some research suggests that sneezing is linked to bright light exposure, sudden drops in temperature, and/or gastrointestinal function. During kratom withdrawal, it may be that thermoregulatory, gastrointestinal, and/or neurochemical reduce the threshold for a sneeze reflex whereby sneezes occur with increased frequency during withdrawal. Avoidance of cold temperatures, minimizing exposure to [indoor and/or outdoor] air pollution with a purifier, and maintaining adequate humidity may reduce sneeze in withdrawal. Perhaps intranasal blood vessel dilation associated with rhinorrhea also [directly or indirectly] leads to sneezing. Spasms or Tremor : Though withdrawal from kratom is not known to cause seizure, it may provoke muscle spasms or tremor. Spasms are considered sudden involuntary muscular contractions, whereas tremor is considered an involuntary quivering movement. It is possible to experience both spasms and tremor, especially if you discontinued kratom too quickly after a long-term. Both spasms and tremor may occur as a result of increased excitatory transmission (norepinephrine, glutamate, and/or acetylcholine) and simultaneous decreased inhibitory transmission (GABA). Spasms and tremor tend to be most severe within the first couple weeks of kratom discontinuation, but should subside within the first month. Anyone who experiences spasms or tremor may benefit from taking steps to reduce psychological anxiety and physical muscle tension. Taking a warm bath, staying physically active, and/or implementing a stretching routine may improve these symptoms. Substances that enhance GABA signaling (e.g. benzodiazepines) and/or dopamine synthesis may attenuate some of the spasms and/or tremor.

: Though withdrawal from kratom is not known to cause seizure, it may provoke muscle spasms or tremor. Spasms are considered sudden involuntary muscular contractions, whereas tremor is considered an involuntary quivering movement. It is possible to experience both spasms and tremor, especially if you discontinued kratom too quickly after a long-term. Both spasms and tremor may occur as a result of increased excitatory transmission (norepinephrine, glutamate, and/or acetylcholine) and simultaneous decreased inhibitory transmission (GABA). Spasms and tremor tend to be most severe within the first couple weeks of kratom discontinuation, but should subside within the first month. Anyone who experiences spasms or tremor may benefit from taking steps to reduce psychological anxiety and physical muscle tension. Taking a warm bath, staying physically active, and/or implementing a stretching routine may improve these symptoms. Substances that enhance GABA signaling (e.g. benzodiazepines) and/or dopamine synthesis may attenuate some of the spasms and/or tremor. Stomach aches : While under the influence of kratom, it is common for food to move slower through the GI tract, leading to constipation and/or indigestion. However, when an individual stops using kratom after an extended duration, it is common for food to move quicker through the GI tract, leading to gastric distress and diarrhea. As a result, it is relatively common to experience severe stomach aches as a withdrawal symptom. Stomach aches that emerge during kratom detox may also be due to adjustments in gut bacteria, micronutrient or electrolyte deficits, and/or dehydration. To cope with withdrawal-induced stomach aches, it is recommended to avoid stimulants (e.g. caffeine) and foods that provoke GI distress (e.g. high-fiber). Staying hydrated, replenishing healthy gut bacteria, and maintaining electrolyte intake may prove useful in counteracting these stomach aches.

: While under the influence of kratom, it is common for food to move slower through the GI tract, leading to constipation and/or indigestion. However, when an individual stops using kratom after an extended duration, it is common for food to move quicker through the GI tract, leading to gastric distress and diarrhea. As a result, it is relatively common to experience severe stomach aches as a withdrawal symptom. Stomach aches that emerge during kratom detox may also be due to adjustments in gut bacteria, micronutrient or electrolyte deficits, and/or dehydration. To cope with withdrawal-induced stomach aches, it is recommended to avoid stimulants (e.g. caffeine) and foods that provoke GI distress (e.g. high-fiber). Staying hydrated, replenishing healthy gut bacteria, and maintaining electrolyte intake may prove useful in counteracting these stomach aches. Suicidal thoughts : Although somewhat uncommon, certain individuals will experience suicidal thoughts and/or ideation after stopping kratom. In the event that you’re experiencing suicidal thoughts, it is recommended to seek immediate medical care, preferably from a psychiatrist who’s familiar with kratom and/or opiate detoxification. Assuming you have no preexisting neuropsychiatric disorder, the suicidal thoughts that occur following kratom withdrawal are likely due to a transient imbalance in neurochemistry. With enough time kratom-free, neurotransmitter secretion and receptor counts should readjust such that suicidal thoughts and depressive emotions subside. It is necessary to note that persons with preexisting neuropsychiatric disorders are at greatest risk of experiencing suicidal thoughts following kratom cessation and careful monitoring is recommended.

: Although somewhat uncommon, certain individuals will experience suicidal thoughts and/or ideation after stopping kratom. In the event that you’re experiencing suicidal thoughts, it is recommended to seek immediate medical care, preferably from a psychiatrist who’s familiar with kratom and/or opiate detoxification. Assuming you have no preexisting neuropsychiatric disorder, the suicidal thoughts that occur following kratom withdrawal are likely due to a transient imbalance in neurochemistry. With enough time kratom-free, neurotransmitter secretion and receptor counts should readjust such that suicidal thoughts and depressive emotions subside. It is necessary to note that persons with preexisting neuropsychiatric disorders are at greatest risk of experiencing suicidal thoughts following kratom cessation and careful monitoring is recommended. Sweating : For certain individuals, the most problematic kratom withdrawal symptom is excessive sweating. The sweat production that occurs during withdrawal may be so extreme, that shirts and/or bedsheets end up completely drenched. Excessive sweat production is often accompanied by chills, hot flashes, cold flashes, and dehydration. Most speculate that an overactive sympathetic nervous system and/or hormonal imbalances that emerge during withdrawal disrupt thermoregulation, which causes increased sweating. Regardless of the underlying cause of sweating, it is recommended to ensure that you’re staying hydrated and replenishing lost electrolytes. Intensification of withdrawal symptoms such as anxiety may potentiate [the already-overactive] sympathetic tone, leading to further sweating. Keeping your stress to a minimum and proactively managing your anxiety might help with the sweats. Realize that while the excessive sweating will eventually stop, it may be among the last of withdrawal symptoms to fade.

: For certain individuals, the most problematic kratom withdrawal symptom is excessive sweating. The sweat production that occurs during withdrawal may be so extreme, that shirts and/or bedsheets end up completely drenched. Excessive sweat production is often accompanied by chills, hot flashes, cold flashes, and dehydration. Most speculate that an overactive sympathetic nervous system and/or hormonal imbalances that emerge during withdrawal disrupt thermoregulation, which causes increased sweating. Regardless of the underlying cause of sweating, it is recommended to ensure that you’re staying hydrated and replenishing lost electrolytes. Intensification of withdrawal symptoms such as anxiety may potentiate [the already-overactive] sympathetic tone, leading to further sweating. Keeping your stress to a minimum and proactively managing your anxiety might help with the sweats. Realize that while the excessive sweating will eventually stop, it may be among the last of withdrawal symptoms to fade. Tiredness : In various stages of kratom withdrawal, it is possible to experience unbearable tiredness such that you feel extremely sluggish or fatigued. Because the tiredness does not always subside quickly, some may assume that they’ve suddenly developed chronic fatigue syndrome. There are many reasons you may feel tired after stopping kratom, including: broken sleep, circadian disturbances, and excessive stress and/or anxiety. Moreover, the CNS is attempting to revert back to homeostasis which can be physiologically-taxing. In most cases, tiredness will reach a peak intensity within the first few days or weeks of cessation. Within a month of quitting kratom, most will notice a returning of some energy – in some cases a little bit, in other cases a substantial amount. Doing your best to practice good sleep hygiene, consuming enough calories, and engaging in low-level physical activity can often help mitigate tiredness during withdrawal.

: In various stages of kratom withdrawal, it is possible to experience unbearable tiredness such that you feel extremely sluggish or fatigued. Because the tiredness does not always subside quickly, some may assume that they’ve suddenly developed chronic fatigue syndrome. There are many reasons you may feel tired after stopping kratom, including: broken sleep, circadian disturbances, and excessive stress and/or anxiety. Moreover, the CNS is attempting to revert back to homeostasis which can be physiologically-taxing. In most cases, tiredness will reach a peak intensity within the first few days or weeks of cessation. Within a month of quitting kratom, most will notice a returning of some energy – in some cases a little bit, in other cases a substantial amount. Doing your best to practice good sleep hygiene, consuming enough calories, and engaging in low-level physical activity can often help mitigate tiredness during withdrawal. Visual changes : Yet another withdrawal symptom that many will notice after discontinuing kratom is a perceived change in vision. Examples of visual changes that may occur during kratom withdrawal include: blurred vision, “floaters” in the visual field, visual sensitivity (especially to bright light), pupillary dilation, and/or increased eye pressure. The visual changes that arise in kratom withdrawal may be due to a combination of: increased sympathetic tone, altered neurotransmission (particularly in the visual cortex), and/or tear duct blockage. If you’re worried about your vision during withdrawal from kratom, it is recommended to get your eyes checked by an ophthalmologist. Assuming the eye doctor cannot pinpoint any problems with your eyes, it will probably be a matter of time before your altered vision reverts back to normal.

: Yet another withdrawal symptom that many will notice after discontinuing kratom is a perceived change in vision. Examples of visual changes that may occur during kratom withdrawal include: blurred vision, “floaters” in the visual field, visual sensitivity (especially to bright light), pupillary dilation, and/or increased eye pressure. The visual changes that arise in kratom withdrawal may be due to a combination of: increased sympathetic tone, altered neurotransmission (particularly in the visual cortex), and/or tear duct blockage. If you’re worried about your vision during withdrawal from kratom, it is recommended to get your eyes checked by an ophthalmologist. Assuming the eye doctor cannot pinpoint any problems with your eyes, it will probably be a matter of time before your altered vision reverts back to normal. Vomiting : Onset of nausea followed by vomiting can occur during kratom withdrawal, especially if discontinued suddenly (i.e. “cold turkey”) after high-dose/long-term use. It’s somewhat unclear as to why individuals experience such severe nausea as to provoke vomiting during withdrawal. While under the influence of kratom, it is known that mu-opioid receptors in the chemoreceptor trigger zone can induce nausea and the vomiting reflex. It is also known that kratom can alter GI function such that individuals feel nauseous and may vomit. Following discontinuation, it is possible that activity in the chemoreceptor trigger zone and/or gastrointestinal tract induce nausea that causes vomiting. Tapering kratom at a slow pace can usually prevent most vomiting in withdrawal. If vomiting occurs in withdrawal, it typically doesn’t persist for more than a few days. To prevent nausea and vomiting after kratom cessation, you may want to ask your doctor about using antiemetics. If you’ve already vomited, be sure to replenish lost fluids and electrolytes, and eat foods that are easy on your gastrointestinal tract.

: Onset of nausea followed by vomiting can occur during kratom withdrawal, especially if discontinued suddenly (i.e. “cold turkey”) after high-dose/long-term use. It’s somewhat unclear as to why individuals experience such severe nausea as to provoke vomiting during withdrawal. While under the influence of kratom, it is known that mu-opioid receptors in the chemoreceptor trigger zone can induce nausea and the vomiting reflex. It is also known that kratom can alter GI function such that individuals feel nauseous and may vomit. Following discontinuation, it is possible that activity in the chemoreceptor trigger zone and/or gastrointestinal tract induce nausea that causes vomiting. Tapering kratom at a slow pace can usually prevent most vomiting in withdrawal. If vomiting occurs in withdrawal, it typically doesn’t persist for more than a few days. To prevent nausea and vomiting after kratom cessation, you may want to ask your doctor about using antiemetics. If you’ve already vomited, be sure to replenish lost fluids and electrolytes, and eat foods that are easy on your gastrointestinal tract. Watery eyes : It may seem as though your eye sockets are flooded with water when ceasing kratom. The watery eyes tend to go hand-in-hand with other withdrawal symptoms such as rhinorrhea (runny nose) and sneezing – relatively analogous to an allergic reaction. Usually watery eyes improve significantly within just a week or two of your last kratom dose. The cause of watery eyes during withdrawal may be associated with blockage of tear ducts, corneal irritation, or inflammation. Keep in mind that certain supplements and/or medications you’re using to manage other withdrawal symptoms may potentiate the preexisting watering. Some claim that it helps to lie down and make a warm “eye compress” (i.e. a warm washcloth) to place over the eyes.

: It may seem as though your eye sockets are flooded with water when ceasing kratom. The watery eyes tend to go hand-in-hand with other withdrawal symptoms such as rhinorrhea (runny nose) and sneezing – relatively analogous to an allergic reaction. Usually watery eyes improve significantly within just a week or two of your last kratom dose. The cause of watery eyes during withdrawal may be associated with blockage of tear ducts, corneal irritation, or inflammation. Keep in mind that certain supplements and/or medications you’re using to manage other withdrawal symptoms may potentiate the preexisting watering. Some claim that it helps to lie down and make a warm “eye compress” (i.e. a warm washcloth) to place over the eyes. Weight changes : The effect of kratom on body weight is generally unknown, but is probably subject to variation based on the specific user, type of kratom, dosage, and term of administration. Nonetheless, it is logical to suspect that if you gained weight while taking kratom, you may end up losing weight when you discontinue. On the other hand, if you lose weight while taking kratom, you may end up gaining weight when you discontinue. The weight change during withdrawal may be due to alterations in appetite (and corresponding caloric intake) and/or physical activity levels (and corresponding caloric expenditure). Various hormones may change after discontinuation as well, possibly leading to noticeable differences in body composition (e.g. increased muscle and less fat).

: The effect of kratom on body weight is generally unknown, but is probably subject to variation based on the specific user, type of kratom, dosage, and term of administration. Nonetheless, it is logical to suspect that if you gained weight while taking kratom, you may end up losing weight when you discontinue. On the other hand, if you lose weight while taking kratom, you may end up gaining weight when you discontinue. The weight change during withdrawal may be due to alterations in appetite (and corresponding caloric intake) and/or physical activity levels (and corresponding caloric expenditure). Various hormones may change after discontinuation as well, possibly leading to noticeable differences in body composition (e.g. increased muscle and less fat). Yawning : Excessive yawning is another extremely common sign of kratom withdrawal. While most people assume that the increased yawning during withdrawal is related to fatigue and/or tiredness, it’s more likely to be associated with changes in thermoregulation. Most available evidence indicates that yawning occurs as an adaptive response to reduce elevations in brain temperature. In other words, we yawn (involuntarily inhale [cooler] air) to keep the brain from overheating. While not confirmed, it’s possible that the brain is more prone to overheating during withdrawal from opioidergic drugs like kratom than usual. As central and peripheral transmission implicated in thermoregulation recalibrates post-discontinuation, yawning should decrease.

Note : Although the above list of kratom withdrawal symptoms is comprehensive, it may be incomplete. If you experience a symptom that was not listed, be sure to share it in the comments section below. Moreover, if you have any questions about a specific symptom and need some advice, it is recommended to consult a licensed medical doctor.

Variables that influence Kratom withdrawal symptoms

Understand that specific symptoms, the severity of each symptom, and total number of symptoms that you experience during kratom withdrawal will be largely subject to individual variation based on influential variables. Variables that are known to influence kratom withdrawal include: rate of discontinuation, kratom specifics (dosage, strain, potency, additives); frequency of use (e.g. twice daily); term of administration (e.g. 1 year); and individual factors (e.g. age, genetics, recovery efforts). For this reason, it is recommended to avoid assuming that your withdrawal experience will be the same as, or automatically similar to, someone else’s.

Rate of discontinuation

The rate at which an individual discontinues kratom may have a profound effect upon the severity of his/her withdrawal symptoms. Quitting kratom cold turkey without tapering down typically yields the most numerous and severe withdrawal symptoms. A fast taper over a period of days may also yield numerous and severe withdrawal symptoms, but they should be less debilitating than sudden “cold turkey” discontinuation. Comparatively, a slow taper over a period of weeks, or even months, tends to yield the least numerous and severe symptoms.

Cold turkey : Most agree that discontinuation of kratom “cold turkey” after a long-term of administration induces intense withdrawal symptoms and prolongs recovery. This is because a person’s physiology has adapted to kratom (neurotransmitter and hormone production, receptor densities, autonomic activation, et al.), and when kratom is discontinued, these adaptations remain – creating significant physiologic imbalances. The reason cold turkey discontinuation tends to be more debilitating than tapering has to do with the degree of physiologic imbalances after the final kratom dose. With tapering, physiology has extra time to recalibrate to functioning with lower quantities of kratom – receptor densities shift, neurotransmitter/hormone secretion change, and autonomic activation readjusts. Cold turkey discontinuation gives zero time to adjust, meaning the person’s CNS is markedly more imbalanced such that more numerous and severe withdrawal symptoms occur. Moreover, since tapering was not conducted, some speculate that this shocks and/or acts as a minor trauma to the CNS. Cold turkey discontinuation is analogous to someone who’s adapted to a diet of 5,000 calories per day cutting down to 1,500 immediately rather than gradually scaling back and allowing their body time to readjust. If you quit kratom cold turkey, expect both more severe withdrawal symptoms and a longer-term recovery.

: Most agree that discontinuation of kratom “cold turkey” after a long-term of administration induces intense withdrawal symptoms and prolongs recovery. This is because a person’s physiology has adapted to kratom (neurotransmitter and hormone production, receptor densities, autonomic activation, et al.), and when kratom is discontinued, these adaptations remain – creating significant p