After confronting extraterrestrials in “Cowboys and Aliens,” Harrison Ford is ready to take on another alien race in OddLot Entertainment’s sci-fi tentpole “Ender’s Game” along with Abigail Breslin and Hailee Steinfeld.

Also onboard are young thesps Aramis Knight, Moises Arias, Jimmy “Jax” Pinchak, Suraj Parthasarathy, Conor Carroll and Khylin Rhambo.

Gavin Hood (“X-Men Origins: Wolverine”) is directing from his own script, adapted from Orson Scott Card’s novel. Summit Entertainment is co-financing and will release the film in the U.S. on March 15, 2013. Set in Earth’s utopian future, “Ender’s Game” stars Asa Butterfield (“Hugo”) as a genius strategist recruited by the government to help destroy an insect-like alien race.

With the latest castings, OddLot now has a marquee star to attract international auds in Ford, as well as three of Hollywood’s leading under-16 thesps in Breslin, Steinfeld and Butterfield.

Ford will play Colonel Hyram Graff, who’s in charge of training young military recruits. Breslin will play Valentine Wiggin, Ender’s older sister, while Steinfeld plays Petra Arkanian, Ender’s trusted right hand.

OddLot, K/O Paper Products and Digital Domain are production partners on “Ender’s Game.” OddLot’s Gigi Pritzker and Linda McDonough are producing with Roberto Orci and Alex Kurtzman via their K/O Paper Products banner, as well as Lynn Hendee, Robert Chartoff and Card. OddLot’s Bill Lischak and K/O’s Mandy Safavi will exec produce with Digital Domain’s Cliff Plumer and Ed Ulbrich. Sierra/Affinity is handling foreign sales for the pic, which will start production in early 2012 in New Orleans.

Ford, who’s no stranger to sci-fi epics, recently signed on to play famed Brooklyn Dodgers g.m. Branch Rickey in Legendary Pictures’ Jackie Robinson biopic “42.”

Steinfeld starred in the Coen brothers’ “True Grit” and will soon play Juliet in Carlo Carlei’s upcoming adaptation of William Shakespeare’s classic romance. Breslin can currently be seen in Garry Marshall’s “New Year’s Eve” and the indie “Janie Jones.”

Ford’s repped by UTA and Ziffren Brittenham, while ICM reps Steinfeld and Breslin. Steinfeld is also repped by Protege Entertainment and Coast to Coast Talent Group. Breslin’s also with Untitled Entertainment.