A suicide bombing claimed by Isis has targeted a US-Kurdish convoy in northern Syria, the second such attack in days.

The attacker drove his car into a checkpoint, injuring several soldiers of Kurdish-led forces, locals said.

A spokesperson for the US-led coalition in Syria confirmed that a joint US and Kurdish-led Syrian Democratic Forces convoy was “involved” in a car bomb attack, adding that there were no US casualties.

Syrian state news agency SANA said the suicide bombing hit a Syrian Kurdish checkpoint near the town of Shaddadeh, in the Hasakeh province.

The Syrian Observatory for Human Rights reported that two US soldiers were injured in Monday’s attack, and five other people were killed. There was no immediate confirmation of that report.

Isis claimed the latest attack in a statement carried by its Amaq news agency.

The SDF said there had only been material damage but acknowledged that Isis militants were expanding attacks, calling them post-defeat phase tactics, after being driven out of most of the territory they once controlled in the country.

“The intensifying of these terrorist attacks and moving sleeping cells to strike will not dissuade us from completing the mission to the end,” the SDF statement said.

On Wednesday, two US soldiers and two other Americans working for the coalition in Syria were killed in a suicide attack in Manbij, in Aleppo province. A further 12 civilians were killed in that attack, which was also claimed by Isis.

In December, Donald Trump claimed that Isis had been defeated in Syria, and ordered a withdrawal of US troops from the country, surprising allies and leading to resignations within his own administration.

Mr Trump has not yet commented on last week’s attack, which represented the single biggest loss of life for US forces thus far in Syria.

Lebanon storm hits Syrian refugee camps – in pictures Show all 15 1 /15 Lebanon storm hits Syrian refugee camps – in pictures Lebanon storm hits Syrian refugee camps – in pictures Khaled Alawi stands with his daughters in front of his home in an informal settlement for Syrian refugees in Akkar, northern Lebanon Richard Hall/The Independent Lebanon storm hits Syrian refugee camps – in pictures A Syrian refugee child looks from his makeshift shelter at Qab Elias Syrian refugee camp in the Bekaa valley EPA Lebanon storm hits Syrian refugee camps – in pictures Children play in front of a shelter in Akkar Richard Hall/The Independent Lebanon storm hits Syrian refugee camps – in pictures Syrian refugees Jose Ahmad al-Jessi, a mother of eight in her 50s, and her daughter Raghad, stand in the doorway of a shop warehouse, where they fled to when their tent flooded on Tuesday Richard Hall/The Independent Lebanon storm hits Syrian refugee camps – in pictures Khaled Alawi surveys the damage to his shelter in Akkar Richard Hall/The Independent Lebanon storm hits Syrian refugee camps – in pictures Syrian refugees sit inside their makeshift shelter in the Bekaa valley EPA Lebanon storm hits Syrian refugee camps – in pictures A young boy stands in front of his shelter in Akkar Richard Hall/The Independent Lebanon storm hits Syrian refugee camps – in pictures A Syrian refugee child plays with snow outside their makeshift shelter in the Bekaa valley EPA Lebanon storm hits Syrian refugee camps – in pictures Richard Hall Richard Hall/The Independent Lebanon storm hits Syrian refugee camps – in pictures A Syrian refugee shovels mud in front of a makeshift shelter follwoing rain storms in the Bekaa valley AFP/Getty Images Lebanon storm hits Syrian refugee camps – in pictures A shelter in Akkar Richard Hall/The Independent Lebanon storm hits Syrian refugee camps – in pictures Syrian refugee children play with snow outside their makeshift shelter in the Bekaa valley EPA Lebanon storm hits Syrian refugee camps – in pictures A Syrian refugee family pumps water after heavy rain in the Bekaa Valley AP Lebanon storm hits Syrian refugee camps – in pictures Syrian refugee children play outside their family tents after a heavy rain at a refugee camp in the town of Bar Elias, in Lebanon's Bekaa Valley AP Lebanon storm hits Syrian refugee camps – in pictures A flooded road leads to an informal settlement for Syrian refugees in Akkar Richard Hall/The Independent

On Sunday, Turkey reiterated to the US that it is ready to take responsibility for security in Manbij, the site of last week’s attack.

In a phone call, Turkish president Recep Tayyip Erdogan told Mr Trump that Wednesday’s bombing was a provocative act aimed at affecting Trump’s decision last month to withdraw US troops from Syria.

Manbij, which US-backed forces captured from Isis in 2016, has emerged as a focal point of tensions after Trump’s decision to withdraw US forces, whose presence there has effectively deterred Turkey from attacking Kurdish forces.