A cyclist has died following a collision with a car on the Princes Highway in Melbourne's south-east.

It is believed a white Holden sedan was travelling north-west along the highway when they collided near the intersection of Dunblane Road in Noble Park shortly before 7am on Tuesday.

The cyclist, a 52-year-old Noble Park man, was taken to the Monash Hospital where he later died.

The male driver of the car stopped at the scene and is assisting police with their inquiries.

Police are appealing for witnesses to come forward.

Anyone with information is urged to contact Crime Stoppers on 1800 333 000.