Five teenage girls have been arrested by police after a failed robbery and assault at a Southern Cross Station liquor store which left one person in hospital.

It's believed a scuffle broke out at the BWS store inside Woolworths when security guards confronted a group of girls attempting to steal alcohol about 2pm on Thursday.

Police arrest five teenage girls in Aurora Lane near Southern Cross Station on Thursday afternoon. Credit:Channel Nine

A Southern Cross Station employee said no staff member had been injured and denied reports a BWS security guard was struck over the head with a bottle.

But an Ambulance Victoria spokeswoman said two people had been treated by paramedics including one man who was taken to Royal Melbourne Hospital with head lacerations.