AP

49ers running back Brandon Jacobs was carried off the field after suffering a potentially significant left knee injury in Saturday night’s preseason game against the Texans.

Jacobs could put no weight on the leg as he was assisted to the sideline. The injury occurred at the end of an eight-yard run that saw Texans cornerback Kareem Jackson collide with Jacobs’ knee. Jackson was also shaken up on the play. Jacobs was down for several minutes immediately after the collision, as 49ers and Texans players huddled all around him.

Jacobs was eventually carted to the locker room.

Signed to add a powerful element to San Francisco’s backfield off the bench this year, Jacobs was trying to rejuvenate his career at age 30. We have a feeling we won’t be seeing him play football for awhile.