Jennifer Aniston’s press tour for “The Switch” hasn’t been without controversial debate, but this time the actress seems to have said one word too many.

The 41-year-old star made her way to “Live! With Regis and Kelly” Thursday and let the word “retard” slip in the middle of a self-deprecating remark.

Aniston was chatting with Regis Philbin and Kristin Cruz from Los Angeles radio station 103.5 about her Harper’s Bazaar Barbra Streisand photos. Cruz asked how she got in the mood to “really embody” Streisand, and Aniston replied, “I play dress-up. I do it for a living, like a retard.”

The audience chuckled, and guest host Cruz kept rolling with a follow-up question, but the comment hasn’t gone unnoticed.

Many are reacting on the Web to Aniston’s statement, with some on Twitter saying that her use of the word has led to a loss of respect for the actress - one person even tweeted that they're thinking twice about heading out to see "The Switch." Meanwhile, The Special Olympics Movement has issued a statement of their own.

“Special Olympics is always disappointed when the R-word is used, especially by someone who is influential to society,” the statement reads. “The pervasive use of the R-word, even in an off the cuff self-deprecating manner, dehumanizes people with intellectual disabilities and perpetuates painful stereotypes that are a great source of suffering and negative stigma.”

The organization added, “We hope everyone will take our pledge to stop using the R-word and promote the inclusion and acceptance of people with intellectual disabilities at www.r-word.org.”

Jennifer Aniston's representation has not yet responded to requests for comment.