The importance of avoiding and treating renal failure cannot be overstated. The kidneys are delicate organs, often the first to be injured by systemic hypoperfusion or other insults. Severe renal dysfunction leads to a cascade of badness, promoting the failure of other organs and eventual spiraling into multi-organ failure.1 Alternatively, if we are can defend a patient's renal function and avoid volume overload, then we will probably improve their prognosis substantially.

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1. Crit Care Med. 2018;46(12):e1196-e1203. PubMed] Jou-Valencia D, Molema G, Popa E, et al. Renal Klotho is Reduced in Septic Patients and Pretreatment With Recombinant Klotho Attenuates Organ Injury in Lipopolysaccharide-Challenged Mice.. 2018;46(12):e1196-e1203.