A man in Michigan died over the weekend after apparently using liquid fentanyl in a vaping device.

The victim, a 39-year-old Alpena man, could not be revived by medics who found him in a home in Maple Ridge Township on Saturday — when he and his wife manufactured the synthetic opioid into a vaping liquid after buying it online, MLive.com reports.

The unidentified man passed out after taking a “number of hits” from the pipe and never regained consciousness, cops said.

Fentanyl, which can be up to 100 times as powerful as morphine, has been the cause of several overdoses — including an Ohio officer who suffered an accidental overdose just by touching powder on his shirt without realizing it was the extremely toxic opioid.

The officer recovered a day later, according to the Associated Press, but the case brought new attention to potential safety hazards for emergency responders — risks that are extremely rare, according to some experts.

Andrew Stolbach, an emergency physician and medical toxicologist at Johns Hopkins University, recently told the Philadelphia Inquirer he hoped those reports didn’t “turn into hysteria,” claiming that just touching fentanyl cannot lead to an overdose or death.

“I don’t want this to make people afraid of doing their jobs,” Stolbach told the newspaper on Friday. “It’s just not plausible that getting a small amount of fentanyl on your skin is going to cause significant opioid toxicity. You don’t absorb enough drug fast enough to get toxicity that way.”

But a spokesman for the Drug Enforcement Agency’s Philadelphia office said extremely potent forms of fentanyl like carfentanil — used to subdue large animals like elephants — are even more fatal than the anthrax used in the bioterrorism attacks in 2002 that killed five people and injured 13 others.

“They are worse [than anthrax] in our opinion,” Trainor told the newspaper. “You have a drug like carfentanil that’s 10,000 times stronger than heroin. Just touching it, is that going to kill you? Probably not. But do you want to take the risk?”

Just 2 to 3 milligrams of fentanyl can induce respiratory depression, arrest and possibly death, according to a 20-page, DEA-produced fentanyl guide for emergency responders.

“When visually compared, 2 to 3 milligrams of fentanyl is about the same as five to seven individual grains of table salt,” the guide reads. “Fentanyl can be ingested orally, inhaled through the nose or mouth, or absorbed through the skin or eyes … If an exposure occurs, seek immediate medical attention as fentanyl and other fentanyl-related substances can be very fast-acting.”