Background: Chrono and photoaging are characterized by a reduction of skin hydration, skin elasticity and alteration in skin pigmentation with the appearance of fine and wrinkles. Antioxidants and exfoliating agents are commonly used in skin aging. In addition, topical retinoids are known to counteract several processes involved in skin aging. However, a major problem of these products is the poor skin tolerability. A cream containing glycolic acid 7%, a mixture of retinoids molecules 0.1% (hydroxypinacolone and retinol vehiculated in glycospheres) and vitamin E 0.5% has been developed. The specific formulation of retinoids in this cream was developed with the aim to increase the stability of the molecules and improving tolerability. So far, no objective data regarding the clinical efficacy of this cream were available.