Boston Children's Hospital in Boston, MA is ranked No. 1 on the Best Children's Honor Roll. It is nationally ranked in 10 pediatric specialties. It is a children’s general medical and surgical facility. It is a teaching hospital.

Established in 1869, Boston Children's Hospital is one of the largest medical centers and research institutions dedicated to pediatric medicine in the country. While its main location is in Boston, campuses span the Northeast. Affiliated physicians and community hospitals operate in Massachusetts, New Hampshire, Connecticut, New York and New Jersey.Boston Children's Hospital has been the teaching affiliate for Harvard Medical School since the early 1900s. The hospital also has a clinical partnership with the Dana-Farber Cancer Institute to research pediatric cancer and blood disorders.The Advanced Fetal Care Center has been a center for innovation related to congenital anomalies, with successes including fetal cardiac interventions in utero to reduce post-delivery fatalities. The gene therapy program aims to treat rare conditions. In 2017, doctors at Boston Children's Hospital were the first to use gene therapy to treat a degenerative brain disease.Community initiatives focus on treatment of asthma, mental and behavioral health, and obesity, as well as affordable housing and food access. The neighborhood partnerships program addresses behavioral health in the community, placing clinicians in schools and community centers to provide mental and behavioral health services to children and adolescents.