Sen. Susan Collins Susan Margaret CollinsSenate GOP aims to confirm Trump court pick by Oct. 29: report The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Senate GOP sees early Supreme Court vote as political booster shot MORE (R-Maine) said Tuesday that she will oppose a controversial circuit court pick by President Trump Donald John TrumpOmar fires back at Trump over rally remarks: 'This is my country' Pelosi: Trump hurrying to fill SCOTUS seat so he can repeal ObamaCare Trump mocks Biden appearance, mask use ahead of first debate MORE ahead of a vote this week.

Collins, the first Republican senator to announce their opposition to Chad Readler’s nomination for the 6th U.S. Circuit Court of Appeals, said she was opposing the pick over his role in a case involving pre-existing conditions.

“Rather than defend the law and its protections for individuals with pre-existing conditions – such as asthma, arthritis, cancer, diabetes, and heart disease – Mr. Readler’s brief in Texas v. United States argued that they should be invalidated,” Collins said.

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“Given Mr. Readler’s role in the government’s failure to defend provisions under current law that protect individuals with pre-existing conditions, I will oppose his confirmation to the bench,” Collins added.

Readler, who previously worked as an assistant attorney general for the Civil Division at the Department of Justice, filed a brief last year supporting a lawsuit filed by Texas and other states seeking to strike down the Affordable Care Act.

Collins added on Tuesday that she “strongly objected” to the Justice Department’s decision.

“In my view, the Justice Department’s severability argument is wrong and implausible. ... I have continuously stressed the importance of protecting Americans who suffer from pre-existing conditions,” Collins said.

The Senate will hold a procedural vote on Readler’s nomination on Tuesday afternoon, where he’ll need only a simple majority to advance.

Democrats and their outside group allies have homed in on Readler’s nomination.

Demand Justice, an outside progressive group, is running digital ads targeting Collins and GOP Sens. Cory Gardner Cory Scott GardnerOvernight Health Care: US coronavirus deaths hit 200,000 | Ginsburg's death puts future of ObamaCare at risk | Federal panel delays vote on initial COVID-19 vaccine distribution The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Senate GOP sees early Supreme Court vote as political booster shot MORE (R-Colo.), Thom Tillis Thomas (Thom) Roland TillisThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting OVERNIGHT ENERGY: EPA head questions connection of climate change to natural disasters | Pebble Mine executives eye future expansion in recorded conversations | EPA questions science linking widely used pesticide to brain damage in children Liberal super PAC launches ads targeting vulnerable GOP senators over SCOTUS fight MORE (R-N.C.) and Joni Ernst Joni Kay ErnstThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Liberal super PAC launches ads targeting vulnerable GOP senators over SCOTUS fight Romney backs pre-election Supreme Court vote, paving way for McConnell, Trump MORE (R-Iowa) over the nomination. All four Republicans are up for reelection in 2020.

If Democrats are going to stop Readler’s nomination they’ll need to flip a total of four Republican senators and keep their caucus united.