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Manchester City's selection woes may just have gone from bad to worse ahead of their huge Premier League tie with Arsenal on Sunday .

Ilkay Gundogen was forced off with a knee injury during the first half of the Wednesday night clash with Watford at the Etihad.

The German, who has become a key part of Pep Guardiola's midfield setup since his arrival in Manchester this summer, was forced off in the final minutes of the first half - following a challenge by Nordin Amrabat - after Pablo Zabaleta had given the hosts the lead.

(Image: Getty Images) (Image: Getty Images)

The injury blow could leave City short in midfield for Arsenal's visit to the Etihad this weekend.

Both Sergio Aguero and Fernandinho are set to miss out through suspension, after their red cards in the hot-tempered 3-1 defeat to Chelsea earlier this month.

(Image: Reuters)

The Brazilian will be serving the final game of his three-match ban, while Aguero's four-match suspension for a dangerous foul on David Luis means he will also miss the boxing day tie with Hull City, having already sat out the 4-2 loss to Leicester and tonight's game.

On top of the Gundogan injury and those suspensions, Guardiola is also still without injured captain Vincent Kompany.

For their part, Arsenal are expected to be without Shkodran Mustafi for the foreseeable future, as well as long-term absentees Santi Cazorla, Per Mertesacker and Danny Welbeck, while Aaron Ramsey is also a doubt.