Texans' Brock Osweiler struggled to connect with DeAndre Hopkins

Texans quarterback Brock Osweiler struggled mightily to connect with star wide receiver DeAndre Hopkins during a win Sunday over the Tennessee Titans despite multiple attempts to force the football in his direction.

The timing was clearly off as the quarterback completed just one of six passes thrown to Hopkins and was intercepted twice on throws intended for the Pro Bowl wide receiver.

It took Hopkins until the fourth quarter of the 27-20 win to catch his lone pass for a gain of four yards to avoid being shut out completely. Hopkins was shadowed effectively by Titans cornerbacks Perrish Cox and Jason McCourty, but it was primarily a case of Osweiler not giving him much of a chance to make a play.

"Just got to go practice," Hopkins said when asked what needs to happen for Osweiler and him to be more productive. "Do it at practice, make some plays and relay it over to the game."

While Osweiler was unable to get into sync with Hopkins, he did find rookie wide receiver Will Fuller for seven receptions for 81 yards and one touchdown.

Tennessee Titans cornerback Perrish Cox (20) breaks up a pass play intended for Houston Texans wide receiver DeAndre Hopkins (10) during the second quarter of an NFL football game at NRG Stadium, Sunday, Oct. 2, 2016 in Houston. less Tennessee Titans cornerback Perrish Cox (20) breaks up a pass play intended for Houston Texans wide receiver DeAndre Hopkins (10) during the second quarter of an NFL football game at NRG Stadium, Sunday, Oct. ... more Photo: Karen Warren, Houston Chronicle Photo: Karen Warren, Houston Chronicle Image 1 of / 101 Caption Close Texans' Brock Osweiler struggled to connect with DeAndre Hopkins 1 / 101 Back to Gallery

The Titans were determined to limit Hopkins' impact.

"It all came down to trying to take their best player out of the game," Titans coach Mike Mularkey said. "I thought they did that."

This marked a season low for Hopkins for catches and yards.

"I think they did some things to obviously take Hop away, credit to them," Texans coach Bill O'Brien said. "We've got to do a better job of getting Hop the ball. That's me. I'm sure he's thrilled with the win, but maybe not really happy with only having that catch in the fourth quarter. We'll work on that and keep trying to get him the ball."

If Hopkins was frustrated by the lack of involvement, it wasn't evident.

Hopkins caught a career-high 111 passes for 1,521 yards and 11 touchdowns last season. He has 17 catches for 227 yards and two touchdowns this season through four games.

"We won, that's all that matters," Hopkins said. "We knew they were going to fight us hard."