The point man for carrying out President Barack Obama's health care law will be stepping down after Republicans succeeded in blocking his confirmation by the Senate, an official said Wednesday.

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Berwick's Dec. 2 resignation was confirmed by a senior congressional official, speaking on condition of anonymity ahead of an announcement by the administration. He will be replaced by his principal deputy, Marilyn Tavenner, formerly Virginia's top health care official.

Forty-two GOP senators — more than enough to derail Berwick's confirmation — had announced their opposition to his nomination months ago. That started a countdown on his temporary appointment, scheduled to run out at the end of the year.