SAN FRANCISCO -- Antrel Rolle and the New York Giants studied Alex Smith so much they practically knew what was coming.

On one play in the third quarter, even running back Ahmad Bradshaw screamed from the sideline: "Trail. He's watching you." Rolle responded, pretended he was playing the ball and sliced in front of Kyle Williams on a short hook.

"He threw the ball right to me," Rolle said.

After a slow start this season, New York's defense saved its best for the 49ers yet again.

Rolle intercepted two passes by Smith, Prince Amukamara picked off another, and the Giants shut down San Francisco in a 26-3 victory Sunday in a rematch of last season's NFC Championship Game.

"I think this is our most complete game all year long," Rolle said.

After outscoring the Bills and Jets by a combined 79-3 the last two weeks, the 49ers (4-2) met their match again. No overtime needed this time, and not much of Eli Manning, either.

Manning threw for 193 yards and one touchdown, Bradshaw ran for 116 yards and a score and New York (4-2) rode that dominant defense and four field goals by Lawrence Tynes to hand outspoken 49ers coach Jim Harbaugh the most lopsided loss of his tenure.

The 49ers had not allowed a 100-yard rusher in previous 22 home games. The last time one was Tennessee's Chris Johnson, who ran for 135 yards on Nov. 8, 2009

What a San Francisco treat.

"We were just waiting for them to play like we know they can play," Manning said of New York's defense. "They played outstanding. They played really well, flying around."