Live music venue the Newtown Social Club has announced that it is closing its doors, blaming the "current regulatory climate in Sydney" for making the business unsustainable.

The King Street venue will shut down on April 23, the club announced on Facebook on Wednesday night, in a message that was shared thousands of times and attracted hundreds of messages of dismay from live music fans overnight.

Next in line: The Newtown Social Club will close its doors on April 23.

"Whilst the live music part of the business was a resounding success, the current regulatory climate in Sydney and the inherent challenges therein have made it unsustainable," the club said.

"We look forward to exploring new opportunities in the future.