– Alongside genotype, prenatal factors such as vitamin D deficiency during pregnancy can influence the development of ADHD, says MD Minna Sucksdorff from the University of Turku.

The study is the first population-level research to demonstrate an association between low maternal vitamin D level in early to mid-pregnancy and an elevated risk for diagnosed attention-deficit/hyperactivity disorder ADHD in the offspring.

The study included 1,067 children born between 1998 and 1999 diagnosed with ADHD in Finland and the same number of matched controls. The data was collected before the current national recommendation in Finland for the intake of vitamin D during pregnancy, which is 10 micrograms per day throughout the year.

Vitamin D Deficiency Still a Problem

The primary investigator, Professor Andre Sourander says that, despite the recommendations, vitamin D deficiency is still a global problem. In Finland, for example, mothers’ vitamin D intake among several immigrant groups is not at a sufficient level.

– This research offers strong evidence that a low level of vitamin D during pregnancy is related to attention deficiency in offspring. As ADHD is one of the most common chronic diseases in children, the research results have a great significance for public health, says Professor Sourander.



The study is part of a larger research project that aims to discover the connections between the mother’s health during pregnancy and ADHD in offspring. The goal is to produce information for developing preventative treatments and measures for identifying children with ADHD risk.



The study was done in collaboration between researchers from the University of Turku, Finland, and Columbia University, New York. The study was funded by the National Institute of Mental Health NIHM (USA) and the Academy of Finland, and it is part of the INVEST flagship programme of the University of Turku. In the study, the researchers used the exceptionally comprehensive Finnish Maternity Cohort (FMC) consisting of approximately 2 million serum specimens collected during the first and early second trimester of pregnancy.

More information:

Professor André Sourander

andsour@utu.fi

The Inequalities, Interventions, and New Welfare State (INVEST) aims at increasing wellbeing of Finnish society during childhood, youth and early adulthood and preventing psychosocial risks compromising such development through innovative interventions. Based on cutting-edge research on the conditions and mechanisms involved at different periods of development, INVEST will evaluate and develop various universal and targeted interventions to improve the efficiency of the current welfare state institutions at critical points of the early life course. INVEST aims at providing a new model for the welfare states that is more equal, better targeted to problem groups, more anticipatory as well as economically and socially sustainable. INVEST is an Academy of Finland Flagship.