Edmonton police have issued a Canada-wide warrant for a man allegedly involved with a shooting death outside an Edmonton nightclub on Saturday.

Police are looking for Arman Dhillon, 21, in connection to the death of Amin Mohammed Abdullahi, who goes by Hamza Tyme.

On Sunday, police were called to the area of 81st Avenue and 105th Street around 2:40 a.m. for reports of a shooting.

When they arrived, police found two men suffering from gunshot wounds. Abdullahi, 30, died in hospital of his injuries. The other injured man, Abdullahi's brother, remains in hospital in serious but stable condition.

Hamza Tyme, 30, died early Sunday after a shooting outside a Whyte Avenue nightclub. (Supplied)

Police say that the crime may be gang related. Ayan Mohammed, Abdullahi's sister, insists that her brothers weren't involved in gangs or drugs and called Abdullahi a "role model in the community."

Dhillon is wanted on 21 separate charges including first-degree murder, attempted murder while using a restricted firearm and aggravated assault

Police warn that Dhillon is armed and dangerous and say he should not be approached.

The homicide is one of six in six recent days that are currently under investigation.