UPDATE

Cricket Australia's National Selection Panel has confirmed Phil Hughes will replace Clarke in the ODI squad for the VB Tour of the UAE.

Hughes was initially left out of the ODI squad, despite scoring two half-centuries in four matches in the Zimbabwe tri-series, but was scheduled to travel to the UAE earlier than the remainder of his Test teammates to spend time working on his batting against spin with coaching consultant Muthiah Muralidaran.

The NSP confirms Phil Hughes as the replacement batsman for Michael Clarke in the ODI squad for the VB Tour of the UAE. — Cricket Australia (@CAComms) September 16, 2014

EARLIER

Australia skipper Michael Clarke has been ruled out of the upcoming one-day international series against Pakistan in the UAE.

Clarke injured his hamstring at training prior to Australia's first match of the recent tri-series in Zimbabwe, then aggravated the problem in his first game of the tour, and scans have since revealed tendon damage in the affected area.

"Since returning to Australia Michael has had a series of investigations that have confirmed a significant hamstring injury," said Cricket Australia physiotherapist Alex Kountouris.

"Importantly, the scans have demonstrated tendon damage which complicates the recovery from this injury.

"As such, he will not recover in time to be available for the ODI series in the UAE.

"We are hopeful that he will be available for the Test series but this will be determined at a date closer to the first Test."

The news concludes weeks of speculation as to Clarke's potential availability for the series and is the latest in a long line of back and hamstring issues for the New South Welshman.

The 33-year-old is even considering departing for overseas tours earlier than his teammates in a bid to avoid injury from launching into full training straight after a long-haul flight.

However, when quizzed upon his return to Australia from Zimbabwe, he was adamant that the problem wouldn't result in a premature end to his ODI career.

“It’s hard for me to look any further down the track than where I am today but I love the game as much as I ever have and the last thing I am thinking about is retiring," he told reporters.