66 Progress (66P) Undock: 66P undocked from Docking Compartment (DC)-1 today at 12:45 pm CDT. Deorbit burn will occur at 3:58 pm CDT with destructive re-entry at 4:35 pm CDT.

Efficacy and Metabolism of Azonafide Antibody-Drug Conjugates in Microgravity (ADCs in Microgravity): With assistance from the Payload Developer this morning, the crew viewed ADC cells with a microscope and injected media into the Multiwall BioCells. Later today the crew will repeat these steps with a second set of samples. The ADCs in Microgravity investigation evaluates new antibody-drug conjugates that combine an immune-activating drug with antibodies in order to target only cancer cells, increasing the effectiveness of chemotherapy and reducing its side effects. In microgravity, cancer cells grow in three-dimensional, spheroid structures that closely resemble their form in the human body, allowing for better drug testing. This investigation may accelerate development of targeted therapies for cancer patients.

Japanese Experiment Module (JEM) Camera Robot: The crew set up the JEM Camera Robot and the ground performed a set of checkout steps. This device is a free-flying camera robot that provides real time video downlink and photographs. It is expected to reduce the crew time requirements to support video recording of activities, especially at the blind spot of existing JEM internal cameras.

Japanese Experiment Module Airlock (JEMAL) Operations: The crew pressurized the JEMAL and performed a leak check. They also gathered Handhold Experiment Platform (HXP) items to support changeout of samples on the Exposed Experiment Handhold Attachment Mechanism 1 (ExHAM 1) this Friday after the ExHAM 1 is retrieved from the JEM Exposed Facility.

Sprint Ultrasound 2: For their Flight Day 90 Sprint Ultrasound 2 session, a crewmember, with support from an operator, configured the Ultrasound 2, placed reference marks on the calf and thigh of their right leg, donned the thigh and calf guides, and performed thigh and calf scans with remote guidance from the Sprint ground team. Ultrasound scans are used to evaluate spaceflight-induced changes in the muscle volume. The Sprint investigation evaluates the use of high intensity, low volume exercise training to minimize loss of muscle, bone, and cardiovascular function in ISS crewmembers during long-duration missions.

Advanced Resistive Exercise Device (ARED) Cable Arm Rope (CAR) Flip: Use of the exercise rope during cable exercises causes a portion of the CARs to experience cyclic flexural loads during operations. To mitigate this issue, the crew removed, flipped and reinstalled the CARs. This results in the ropes being “pre-stretched” which will double the life of the CARs, reducing the number of ropes that need to be built, tested and flown in the future.

Today’s Planned Activities

All activities were completed unless otherwise noted.

Antibody Conjugates Glacier Sample Removal

Combustion Integrated Rack Alignment Guide Install

Photo/TV Camera Mounting Assy Thermal Blanket Move

Ultrasound 2 HRF Rack 1 Power On

Locating EVA hardware and tools

Sprint Ultrasound Operations – Subject

Sprint Guide Donning Operator

Antibody Conjugates Microscope Operations

24-hour ECG Recording (start)

Antibody Conjugates Inoculation

JEM Camera Robot Activation

JEM Camera Robot Flight Checkout Part 2 Support

24-hour Blood Pressure Recording (start)

JEM Camera Robot Deactivation

MELFI -1 Dewar 3 Inventory

Inventory Management System (IMS) Conference

ISS HAM Service Module Pass

ISS HAM Radio Power Down

JEM Airlock Press

Handhold Exp Platform #1 (HXP1) Item Pre-Gathering.

Monitoring shutter closure on windows 6, 8, 9, 12, 13, 14

Antibody Conjugates Glacier Sample Removal

JEM Airlock Leak Check

BEAM Intermodule Ventilation (IMV) Duct Inspection and Cleaning

USOS Window Shutter Close

ESA Active Dosimeter Personal Storage Device Troubleshooting part 1

Antibody Conjugates Microscope Operations

Extravehicular Mobility Unit (EMU) Swap

Battery Stowage Assembly (BSA) Operation Termination

Russian Extravehicular Activity (EVA) Tool Gather

ABOUT GAGARIN FROM SPACE. Equipment gathering for SSTV session

Antibody Conjugates Inoculation

MRM1-FGB Screw Clamp Tightening

Handover of EVA tools for EVA No.43 from USOS

Russian Extravehicular Activity (EVA) Tool Transfer

ESA Active Dosimeter Personal Storage Device Troubleshooting part 2

Multi-purpose Small Payload Rack (MSPR) Two-Phase Flow Experiment Equipment Activation

Photography of Progress 435 Docking Assembly from SM Window No. 7 while undocking from DC1

On MCC Go Mode DC1-Soyuz PEV to CLOSED position

Reconfigure LAB camcorder and Dual Canon Li-Ion Battery Charger to nominal config

Completed Task List Items

LAB O2-Port Configuration

Crew Quarters Radiation Brick Audit

Ground Activities

All activities were completed unless otherwise noted.

Sprint Ultrasound ops support

66P Undock

Charcoal Filter Packaging Verification

Three-Day Look Ahead:

Friday, 07/21: Node 2 Bacteria Filter R&R, CIR Rack Ops, Handheld External Platform Ops

Saturday, 07/22: Crew off duty, housekeeping

Sunday, 07/23: Crew off duty

QUICK ISS Status – Environmental Control Group: