An unmanned cargo ship destined for the International Space Station disintegrated minutes after being launched from the Cape Canaveral Air Force Station in Florida on Sunday morning, NASA said, raising questions about how the agency and its partners will continue keeping the station supplied.

It was the third loss of a cargo ship headed to the space station in the past eight months.

However, NASA officials said they had prepared for such a mishap, and do not anticipate any major disruptions to the operations of the space station.

The countdown had proceeded without a hitch or worries about weather, and the 208-foot-tall Falcon 9 rocket, built by Space Exploration Technologies, better known as SpaceX, lifted off at 10:21 a.m.

But 2 minutes, 19 seconds later, just as George Diller, the commentator during a NASA television broadcast said, “Data coming back shows vehicle on course, on track,” a white cloud emerged from the rocket’s midsection. Moments later, a rain of debris started falling toward the Atlantic Ocean more than 20 miles below.