Channel Ten is poised to axe its ailing breakfast show Wake Up and its early, morning and late news bulletins – forcing at least 50 staff out of their jobs.

It is believed the struggling network will announce the program cancellations and job cuts as early as this week.

Wake Up hosts Natarsha Belling and James Mathison.

A senior Ten executive told Fairfax Media the rumoured "hundreds" of redundancies "might be a little bit exaggerated ... there's no number to put to it yet. There might be some sort of detail released later in the week."

Another source also said Ten intended to announce the cuts soon.