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Charlie Murphy, Eddie Murphy’s older brother and an accomplished funnyman in his own right, died Wednesday in New York after a battle with leukemia.

The 57-year-old funnyman’s passing was confirmed by his rep Domenick Nati.

The elder Murphy’s manager told TMZ that his client had been undergoing chemotherapy.

At 10 p.m. Tuesday, the Brooklyn native tweeted, “One to Sleep On: Release the past to rest as deeply as possible.”

“Our hearts are heavy with the loss today of our son, brother, father, uncle and friend Charlie,” the Murphy family said in statement Wednesday evening. “Charlie filled our family with love and laughter and there won’t be a day that goes by that his presence will not be missed. Thank you for the outpouring of condolences and prayers.”

His next gig had been scheduled for May 13 at the Joe Louis Arena in Detroit, appearing with Cedric The Entertainer, Eddie Griffin, D.L. Hughley and George Lopez in “The Comedy Get Down.”

After a recent “Get Down” show, Lopez said Murphy texted his co-stars: “Great seeing you guys and living the magic last night. Great show brothers!!!!!”

“I’m heartbroken at the passing of our brother Charlie,” Lopez wrote on Instagram with a picture of the two of them.

Lopez said Murphy was never shy in sharing love and warmth.

“In relationships you never want to leave anything unsaid, our conversations before shows and after shows we all told each other and Charlie how we felt! Keep his family in your thoughts and in your prayers and keep a space for Charlie in you’re [sic] heart.”

Cedric The Entertainer also paid tribute via Instagram and called Murphy a “bad man and funny af.”

“He was honest and straight shooter, no BS kinda dude, awesome Father and family man,” Cedric wrote.

Cedric said he was always impressed at how Charlie Murphy handled the fame of his younger brother, while etching a comedy career of his own.

“Had a gregarious laugh that would make you laugh, he stood on his own 2 feet as a man and as a comic even in the shadows of the brother of one of the greatest to have ever done it,” according to Cedric. “Listening to Charlie tell stories of his life was truly one of my greatest past times [sic].”

Murphy is survived by three kids after his wife, Tisha Taylor Murphy, died of cancer in 2009.

The comic loved performing – but adored his family more,

“After every gig, he rushed home to be with his kids,” Hughley tweeted. “He died with gigs on the books.”

Ice Cube said he owed a bit of his career to Charlie Murphy.

“Damn, sorry to hear about my friend Charlie Murphy,” tweeted Ice Cube, who made his directorial debut in the movie “The Player’s Club” with Murphy. “He took a chance on a young director in The Player’s Club. Always made me laugh. RIP.”

Murphy’s on-screen credits include “CB4,” “Our Family Wedding,” ”King’s Ransom,” “Mo’ Better Blues,” “Night at the Museum” and “Jungle Fever.”

He and his younger brother are both credited with writing the movies “Vampire in Brooklyn” and “Norbit.”

Charlie and Eddie Murphy appeared on screen together in “Harlem Nights” in 1989 and “Norbit” in 2007.

Fellow Brooklyn funnyman Chris Rock lamented Murphy’s passing, tweeting: “We just lost one of the funniest most real brothers of all time. Charlie Murphy RIP.”

Murphy might be best known for playing in the most hilarious pickup basketball game in entertainment history.

Back in the mid-’80s when Eddie Murphy’s comedy and Prince’s music careers were taking off, their crews hung out one late night. Prince invited the whole party back to his house to play basketball.

Murphy’s crew changed into athletic gear to play Prince and his pals — even as they were still dressed in frilly concert costumes.

“It was wild. I was like they ain’t thinking about playing ball in that, but they were,” Charlie Murphy narrated in a skit by Dave Chappelle that immortalized the game.

Murphy recalled mocking Prince: “You know what we’re going to call this, the shirts against … the blouses.”

That comment didn’t sit well with the Purple One.

“And when I said that, this [fired-up] look came on his face and I’m looking back at him thinking to myself, ‘What are you angry about? I mean you know where you got that shirt from, and it damn sure wasn’t the men’s department.’”

Prince’s crew went on to crush the Murphys and their pals.

Charlie remembered Prince, who played high school basketball, crossover dribbling like Allen Iverson and rebounding like Charles Barkley

“I mean I kinda learned something that day — never judge a book by its cover,” Murphy recalled. “This cat (Prince) could ball, man.”

After the Prince-led wipeout, the host famously served his guests pancakes.

With Post wires