People living near the epicentre of Australia's biggest earthquake in 15 years have reported being shaken, but otherwise escaping unscathed.



The 6.1 earthquake struck near Ernabella, in South Australia's far north, just before 8.30pm local time (9pm AEDT) yesterday.



Ernabella, an indigenous arts hub, is home to about 500 Aboriginal people, with more living in about six communities in the surrounding region.



The remote area is just south of the border with the Northern Territory, about 317 kilometres south-west of Alice Springs, 230 kilometres south-east of Uluru and 415 kilometres north-west of Coober Pedy.



Geoscience Australia seismologist David Jepsen said people in the communities around the earthquake epicentre had reported strong shaking.



"An event like this, there are a number of Aboriginal communities around there and they have experienced strong shaking," Dr Jepsen said.



"We've heard from them, people have felt strong shaking, but we haven't heard of any damage yet, but there is that possibility."



There have been several aftershocks since the earthquake.



Yesterday's earthquake followed two quakes in the area in the past week. The first, on March 16, measured 4.3 magnitude and the second on March 20 was 3.8 magnitude.



Yesterday's quake is Australia's biggest since a quake measuring 6.3 was recorded off Collier Bay on Western Australia's far north coast in 1997.



"This (Ernabella) earthquake would have been felt in Yulara (near Uluru), only weakly in Alice Springs and maybe as far as Coober Pedy," Dr Jepsen said.



South Australia Police said no injuries or damage had been reported.



Dr Jepsen said the region's earthquakes were caused by the release of stress from the earth's crust, built up as the Indian-Australian tectonic plate moves, squeezing South Australia sideways by about 0.1 millimetre each year.



He said on average there were about 200 earthquakes of magnitude 3.0 or more in Australia each year and one earthquake above magnitude 5.5 about every two years.



The 1989 earthquake in Newcastle, New South Wales that killed 13 people was a 5.6 magnitude event and the 2011 Christchurch earthquake that killed 185 people in New Zealand was 6.3 magnitude.



Australia's largest recorded earthquake was in 1941 in Meeberrie, in central-west Western Australia, with a magnitude of 7.3, but there were no fatalities.



AAP