For a childless 20-something male programmer, fueled by caffeine and ambition and seeking millions in VC funding, the San Francisco Bay Area is North America's startup hot spot. But if you're looking for the most plausible contender to soon supplant it, look to a city a couple thousand miles east. It's home to companies that might have a bit more humanity, run by well-adjusted entrepreneurs building sustainable businesses that employ a talented and diverse workforce. Welcome to Toronto.

$69 All-in cost of Toronto's premium office space, in US$ per square foot, versus $95 in NYC's financial district and $111 in San Francisco $1,532 Toronto's average one-bedroom apartment rent, in US$, versus $3,239 in San Francisco 189 Amount by which Toronto's population increased every day between 2011 and 2015 4.5% Toronto's annual employment growth, compared with 0.7% for Chicago and 1.6% for Los Angeles 6% Unemployment rate in Toronto, compared with 3.5% in Boston and 3.7% in San Francisco 3.5% Ontario corporate income tax rate on first $500,000 in profit $0 Cost of basic health insurance for eligible Toronto residents Sources: U.S. Bureau of Labor and Statistics, Statistics Canada, Toronto Real Estate Board, JLL, Yardi Matrix.

World-beating, people-centered companies have long been birthed and thrive in Toronto, including Four Seasons Hotels and Resorts and MAC Cosmetics. It's a natural home for the kind of people who really start companies (rather than the people who start companies in the movies): midcareer men and women, who care not only about their work but also about their families. Toronto's health and family-leave benefits are more generous than those found in the United States. That, coupled with its strong school system, does wonders in terms of providing opportunities by taking certain key stresses out of the equation.

It also acts as a giant magnet for the academically ambitious, not only from within Canada but from all over the world. Its slew of world-class universities, including the University of Toronto, York University, and, just to the west, the University of Waterloo and the University of Western Ontario, attract tens of thousands of smart students every year. As they graduate and look to settle down and start families, many, happy with the lifestyle Canada's largest city affords, stay in Toronto. As a result, founders there can hire people they'd never be able to attract in Silicon Valley.

"It's good to be a big fish in a smaller pond, with access to all the A players," says Allen Lau, the co-founder and CEO of the Toronto-based online publishing platform Wattpad. "In the Valley, Facebook and Google pay $10 million a year, and I would mostly have access to C and D players. That's why we chose not to open an office there." Of the relatively small number of cities where there are lots of great engineers, Toronto is the one where it's most realistic to expect that those people will accept a job at a midsize startup.

At the same time, adds Lau, Toronto offers a broad range of skills, industries, and amenities. "It's a finance center and a media center," he says. "There are a few things we are very good at. There's a good public school system and universal health care. I don't even need to think about whether I have health insurance. That helps me to be focused on my company."

Canada is also one of the most immigrant-friendly countries in the world, an enticing alternative for the world's increasingly mobile educated classes. More than half of Toronto's population was born outside Canada. That has done wonders for the city's talent pool. Along with the weak Canadian dollar, the steady influx of new workers has helped keep salaries from spiraling up to San Francisco or New York City levels.

And while U.S. companies naturally start out with national ambitions and a single language, Canadian companies think internationally from the beginning (U.S. and Canada) and in at least two languages (English and French). If your company deals with multiple countries, currencies, and languages from the start, that makes it easier to add new ones as it grows. Should your business require funding, Toronto's diversity and inter­national outlook make it easy to seek money anywhere in the world. Wattpad, for instance, has raised money from Silicon Valley VCs, Chinese conglomerates, and Filipino telecoms.

Toronto is far from perfect. Real estate isn't cheap, commutes can be grueling, and any city that made the late Rob Ford its mayor is capable of idiosyncratic politics. Still, when Google subsidiary Sidewalk Labs wanted a location to build the urban center of the future, it chose Toronto. The urbanist Richard Florida, who moved to Toronto to take a job at the Martin Prosperity Institute, believes that it "is even more of a talent magnet than New York City." A case in point: Geoffrey Hinton, one of the top machine-learning scientists in the world, who could get a great job at any university, was finally poached from Carnegie Mellon by the University of Toronto. He now works part time for Google--largely out of Canada.