Maine Gov. Paul LePage (R) says Sen. Susan Collins Susan Margaret CollinsGraham: GOP will confirm Trump's Supreme Court nominee before the election Gardner signals support for taking up Supreme Court nominee this year Tumultuous court battle upends fight for Senate MORE (R-Maine) would be “highly unlikely” to win the GOP gubernatorial primary if she decides to run for governor.

"I will say this right away. I do firmly believe deep down in my heart that Susan Collins, in order to become the governor of the state of Maine, will have to run as an independent, and she's highly unlikely to win a Republican primary," LePage said in an interview with Maine's WGAN news radio, first highlighted by Politico.

Collins has said she is considering a run to be her state’s governor and will make a decision by the end of September. She is not up for reelection for the Senate until 2020.

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If Collins won the general election for governor, LePage would pick her successor. His term as governor ends in 2018.

LePage, though, predicted that if Collins gets through the GOP primary "she wins."

Collins, a moderate Republican, bucked her party earlier this summer, voting against a bill to repeal ObamaCare. Collins cited the bill’s deep cuts to Medicaid.

LePage hit Collins for her vote.

"Let's see her fix Medicaid, let her do a better job than I did in trying to get our accounts balanced and get this state under fiscal responsibility,” he said. “She has no idea what she's stepping into when it comes to Medicaid expansion.

"She really has no idea, she's doing exactly what Angus King Angus KingShakespeare Theatre Company goes virtual for 'Will on the Hill...or Won't They?' On The Trail: How Nancy Pelosi could improbably become president Angus King: Ending election security briefings 'looks like a pre-cover-up' MORE did, and look at the mess he left me," he added.

Collins previously ran for governor and lost in 1994 to now Sen. Angus King (I-Maine).