An 18-year-old has been seriously wounded after being allegedly stabbed by two men in a Melbourne CBD apartment, with his attackers now on the run.

The two men were allegedly visiting the unit on Little Bourke Street when they stabbed the 18-year-old during an altercation just before 7am today, police said.

Both of the alleged attackers fled on foot, and are yet to be found.

The victim, from North Coburg, was taken to hospital with serious but non-life threatening injuries.

Another man also received minor injuries but is refusing to help police.

A number of others who were at the scene are speaking with detectives as investigations continue.

Anyone with information is urged to contact Crime Stoppers on 1800 333 000