Sen. Johnny Isakson Johnny IsaksonLoeffler paints herself as 'more conservative than Attila the Hun' in new campaign ad Georgia GOP Senate candidates cite abortion in pushing Ginsburg replacement Loeffler: Trump 'has every right' to fill Ginsburg vacancy before election MORE (R-Ga.) is predicting that congressional Republicans will be more willing to work with Hillary Clinton Hillary Diane Rodham ClintonJoe Biden looks to expand election battleground into Trump country Biden leads Trump by 12 points among Catholic voters: poll The Hill's Campaign Report: Biden goes on offense MORE than they have been with President Obama, should she be elected president.

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Democrats have repeatedly blasted Republican tactics under the Obama administration, arguing that GOP senators have reached a record level of obstruction on legislation and nominations.

Isakson's comments come as Clinton has narrowly trailed Trump in the typically red state, feeding Democrats hopes of expanding the electoral map. According a RealClearPolitics average of polls, the GOP presidential nominee is leading by less than 5 points.

The Georgia Republican isn't the only one who is open to collaborating with a hypothetical Clinton administration, even though multiple congressional committees are still probing her time atop the State Department.

"I can do two things at once. I can criticize and I can cooperate," he told The Hill last month. "I don't see that they're inconsistent."

"We'll do our duty, you know regardless of who is president," the Senate's No. 2 Republican told The Hill last week. "The people we serve want us to to work together for their benefit so that's certainly my posture."

Cornyn declined to name specific issues that he believes he and Clinton could work well together on.

Republicans are defending 24 Senate seats in November, including a handful in purple states previously carried by President Obama. They will lose control of the Senate if Democrats net five Senate seats, or four if Clinton also wins the White House.