Traci Des Jardins, the French-trained California chef who helped define a new style of fine dining in San Francisco, will close her flagship restaurant, Jardinière, on April 27.

Ms. Des Jardins, 53, who opened the elegant restaurant in 1997 in what was then a struggling neighborhood near the city’s Civic Center, announced the closing to her staff on Monday.

“The restaurant is pretty healthy, but it’s not thriving,” she said in a phone interview. “I looked at changing the concept and the interior, but I just didn’t want to do it. I’m ready to put it to rest. I’m tired of fine dining.”

The San Francisco restaurant landscape has changed significantly since Jardinière opened 21 years ago. Then, the first dot-com boom was heating up, Willie Brown, the city’s first African-American mayor, had just been elected, and San Francisco was still rebuilding from the devastating 1989 Loma Prieta earthquake.