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This weight loss pills that actually work article got created while trying to get a hold of working, natural and useful diet pills that can actually aid in weight loss, I realized there’s a lot of fluff on the internet these days. I’ve done my extensive research through my beloved examine.com. What I like most about these guys is their strict reliability on studies. There’s no made up benefits for any of the supplements, unlike most who like to randomly throw some unresearched statements with the sole purpose of selling you something.

I eventually found the top 35 weight loss pills that actually work in helping you lose weight. So which ones are they? As a summary to the article which I honestly recommend you to keep on reading, here they are: Resveratrol, Capsaicin, Evodia Fruit, Garlic, Fish Oil,Spirulina, Yerba Mate, Alpha-GPC, Yohimbine, Eleutherococcus Senticosus, Spirulina, Ashwagandha, 5-HTP, Black Cumin, 7-Keto DHEA, Coleus Forskohlii, Eurycoma Longifolia Jack, Grapefruit, Gynostemma Pentaphyllum (Southern Ginseng), Pterostilbene, Rose Hip, Caralluma Fimbriata, Caffeine, Berberine, L-Carnitine, Green Tea Catechins, Guarana, Melatonin, Cissus Quadrangularis, Fucoxanthin, Licorice, Leptin, Ghrelin, Adiponectin, Turmeric with Bioperine

The problem is, most of this fluff went viral because of the companies advertising absurd and false claims such as “lose 10 pounds in 1 week using supplement X”.

I’m not saying it’s impossible, but any supplement that “helps” you lose that much weight in such a short period of time is not worth it due to the negative long-term effects it may have, from loose skin (caused by such sudden changes in fat mass) and putting all that weight back on soon after to turning your digestive system upside down or worse, death (yes, there are weight loss supplements that can cause it – we’ll get there)

I decided to compile a list based on real studies which could prove the efficiency of a supplement. I found 35 supplements that actually help you lose weight. These mostly work at a slow and steady pace, but they do work and they’re healthy for your body.

Most of the supplements that help you lose a lot of weight FAST are tremendously harmful to your body. Once I started writing this article, I realized that the more weight a supplement makes you lose in a short period of time, the unhealthier it is.

For example, let’s take Resveratrol vs 2-4 DNP (which I haven’t included in the list because I cannot recommend it.). Resveratrol boosts the weight loss with around 3.2 pounds per month. That means you win around 2 weeks of healthy dieting WITHOUT any downsides (considering you’re losing about 1 kg per week.).

2,4 DNP is a former compound found in explosives and dyes. Someone decided to test it as a supplement. It strikes you with fever, dizziness, nausea and it could kill you as it killed others. It boosts weight loss by 3 pounds PER WEEK. I did not include any of these kinds of supplements on this list. If those pills are what you’re looking for, you’re not in the right place.

A supplement shouldn’t be seen as more than what it is. It’s an addition to your dietary intake which brings additional BENEFITS, but pills, teas, and vaccines should never replace a healthy diet, nor you should aim to do so. If you’re willing to go down this path, do it wisely. It’s better to lose 4 pounds in 2 weeks than lose them in 1 week and put them back on the next one.

This list has been compiled based on three factors:

Toxicity (How toxic the compound is for your body)

Other Benefits (e.g. Cardiovascular Function Increase, Skin Elasticity Improved etc.)

Weight Loss Improvements (WLI) (=How much more weight was lost during supplementation). I would ask you not to rely on this statistic alone. You might be missing out for the following reasons. Not every supplement is researched as thoroughly as the next one, and some don’t even have a WLI available except for mice. Some of the supplements provide you with great benefits that go beyond burning fat cells and provide a better balance to your body. Missing out on those would be unfortunate.



And it contains supplements that work through:

Suppressing Appetite: These lower your hunger and food cravings. They do so by feeding your body’s receptors with stimuli telling them you’re full and cool, therefore your hunger not being triggered. These are a great choice, but you need to make a schedule so you make sure you actually eat although you’re not hungry.

Burning Fat Cells: These supplements make your body provide it’s needed energy by using fat as energy, instead of glucose.

Thermogenesis: In simple terms, this means they increase your body’s metabolism over a few hours after being taken. Faster metabolism results in more energy used, which means more calories burned. That’s what we aim for.

P.S: This will be a long post. Prepare a cup of coffee or bookmark this page so you can catch up later!

P.S.2: You obviously don’t have to buy all the supplements and their effects won’t stack up. Choose 3 or 4 tops which have suitable effects for what you need, and go with those.

Disclaimer: This post contains affiliate links.

By the way! I’ve recently released an absolute BEAST of a weight loss program, that focuses on giving you EVERYTHING you need to lose weight. And I mean, everything. I even called it Complete35, because it’s..complete!

Now let’s get cracking!

35 Weight Loss Pills That Actually Work

#1 – Resveratrol

Resveratrol is a powerful antioxidant found in red wine and grape skin – it also resides in nuts and berries, in smaller quantities.

Although it’s falsely been advertised as a lifespan increaser, its huge list of benefits is definitely contributing to improving the quality of life.

Being a potent anti-inflammatory supplement, Resveratrol helps maintain a healthy heart by reducing the “bad cholesterol” inside the blood vessels and, of course, by preventing(or lowering) inflammation.

Its anti-oxidant feature also shines in preventing the apparition of Alzheimer’s disease. Free radicals (a.k.a toxins) alter the neurons functionality and secretion. These neurons end up producing defective protein, that build up as a plaque around them. This plaque then interferes with synapses, preventing optimal neuronal transmission while growing in size, therefore affecting more and more neurons and synapses in time.

Anti-oxidants form a barrier that protect the cells (in this case, neurons) from being harmed by free radicals and therefore, prevent different diseases at a multi-systemic level. Resveratrol is one of the strongest ones in this matter.

Resveratrol is also thought to both prevent and treat diabetes, most likely through improvements towards insulin sensitivity. It also slightly lowers the blood pressure of those who suffer from diabetes.

Weight loss is achieved through an increase in thermogenesis (heat expenditure of the body increases, which means more calories are burned – including fat). Although the WLI of the supplement is not amazing, I would recommend you not to get hung up on this statistic. There’s much more to these kinds of supplements than a few extra pounds lost. The body will be much more inclined to lose those pounds if you provide it with a healthy environment.

Other Benefits: Improved Blood Flow (including the one to the brain), Insulin Sensitivity, Decreases Triglycerides, Bad Cholesterol (LDL-C) and Helps Clear Acne.

How to take: Dosage can vary – from 250 mg to 2000 mg it exerts all of its effects, to a different degree. (More brings results faster)

Toxicity: Low, up to 5g can be taken without any side effects, and after the 5g threshold, some dizziness may be present.

WLI: Around 3.2 pounds extra lost while taking resveratrol (per month)

Do not take if: Safe

#2 – Capsaicin

Capsaicin is what makes you breathe fire whenever you eat hot peppers. Its perceived hotness is measured in Heat Units, which refer to how many times the alcohol or sugar-water dilution has to take place in order for you to not perceive the burn anymore. For example, 40,000 Heat Units need to be diluted 40,000 times in order to not feel hot.

Fun fact: Although not advertised as such, capsaicin has one great hidden effect under all the others – it helps you relax and acts as an adaptogen (=helps you easily adapt to certain situations). It does so by stimulating your adrenal receptors, which eventually get desensitized to being so easily stimulated and therefore, less adrenaline is secreted.

Adrenaline is the hormone that’s responsible for the “flight or fight” responses which appear in certain life-threatening occasions or, for some of us, even during social interactions. Capsaicin might help you relax during the latter, along with Ashwagandha and Rhodiola Rosea.

Capsaicin is quite amazing and has effects desirable by… probably every athlete in the world, given that it stimulates muscle protein synthesis (therefore improving muscle mass), increases performance and, of course, burns and prevents fat from being developing in your body.

In studies on mice it seems to also suppress appetite, but loses its effectiveness after a week or so. If you’re interested in going on a diet, you might spare yourself of the initial cravings by using this short-lived benefit.

As a supplement, it increases your body’s temperature, hence your metabolic rate and calories burned. It also reduces appetite and fat cell production. Best works when taken 1 hour before exercise.

Other Benefits: Reduces Inflammation, Pain, Anti-Cancer Effects, Performance Enhancer

How to take: 0.5-1g 3 times a day before meals

Toxicity: Harmful to people with digestive system problems, such as ulcers as it can irritate. There have been a few deaths noted, so you should consult your doctor before beginning supplementation.

WLI: –

Do not take if: You have any kind of digestive disease (ulcers, any kind of inflammation

I recommend going for 40,000 Heat-Units if you’re just starting out with Capsaicin. After a few months of usage, you can upgrade to 100,000 Heat-Units.

This Solaray Cayenne has the best price-to-quality ratio:

#3 – Evodia Fruit

Evodia is a berry with effects similar to Capsaicin. It increases heat in the body, being a natural fat burner while also decreasing fat cell formation. It’s also used in Chinese Medicine as a drug for various problems, including hernias, headaches, and digestive problems.

Coptis Chinensis increases Evodia Extract’s absorption, so you might want to take these diet pills together. It’s quite the same dynamic Turmeric with Bioperine has – one doesn’t get well absorbed without the other. On the other hand, the Evodia berry seems to be digested and absorbed well.

Although Evodia is similar to capsaicin, there’s one interesting thing one study has identified in tests on mice. Two groups were fed obesity causing diets, one of which was also given Evodia for a 21-day period. The group fed with Evodia has had a 10% decrease in general mass and a 28% decrease in perirenal fat, while the group of mice that did not receive Evodia, had reached obesity. The two groups diet was the same, yet there were no differences in eating patterns. Could this mean Evodia allows you to eat more while bringing most of the effects of capsaicin?

Other Benefits: Soothes Headaches, Cold-induced Hernias, Nausea, Abdominal Pain, Acid Regurgitation, Diarrhea, Vertigo Treatment, Kills Cancer Cells

How to take: 3-9g, 3 times a day

Toxicity: none.

WLI: Has not been studied, but the effects look promising towards fat loss.

Do not take if: Generally safe to take, but usage during pregnancy could be dangerous. Also, Evodia slows blood clotting and supplementation should be avoided 2 weeks before and after surgeries.

Although quite expensive, this is the only decent product on the market and some people swear by it. I personally haven’t tested it, but if Evodia interests you, I would advise you towards it.

#4 – Garlic

Garlic is simply a wonder vegetable which has a huge array of life benefits, including a soft improvement in metabolic rate and a further

Garlic, just like Resveratrol, seems to also be effective in preventing Alzheimer’s (and even treating it!) by preventing the production of the plaque and even supporting its degradation.

It promotes weight loss, while also turning fat into brown fat (which is easier to shred). You can either go for diet pills or eat garlic as it is, but the smell might make some people turn their heads when you’re talking. The supplements could also induce the smelly mouth as well, so I would advise you to go towards an odorless product.

Other Benefits: Increases HDL-C (Good Cholesterol), Decreases LDL-C (Bad Cholesterol), Decreases Total Cholesterol, Lowers Triglycerides, Blood Pressure, Greatly Improves Immunity (Those who supplemented their diets with garlic had 60-70% fewer colds than those who didn’t while also having their colds shorter, with fewer symptoms and easier to cope with), Lowers Arterial Stiffness, Anti-Cancer Effects, DNA Damage decrease, Increases Longevity and Brain Function, Antioxidant.

How to take: 0.6-1.2 grams a day, one or multiple doses. May become toxic in high doses, so you should not abuse it as a supplement.

Toxicity: May cause heartburn, allergies, garlic scent at high doses.

WLI: Although noted that it’s a great supplement for fat loss, percents were not found.

Do not take if: Safe

This is the product with the best price-quality ratio. It’s also the most reviewed and has kept a decent rating throughout the test of time. One especially great feature of it is the odorless one, so you’ll have to chew less gum while you’re supplementing with it.

#5 – Fish Oil

Fish Oil is commonly used to refer to eicosapentaenoic acid, and docosahexaenoic acid ( EPA and DHA). These are both omega-3 fatty acids, often found in fish and other animal products. Besides fish, the highest omega-3 concentration resides in flaxseeds, chia seeds, walnuts and soybeans.

Fish oil is also a widely advertised wonder-supplement and for a good reason. With all the benefits it brings, it’s a good choice to include it in your diet whether your goal consists of fat loss or not. Not only does it increase your metabolism, but it also brings plenty of other benefits such as lowering depression, reducing the risk of breast cancer and diabetes. It also keeps your blood vessels healthy.

Overall, it promotes equilibrium which is always important for those who want to shred some fat and be able to strictly hold on to their diets. And to those who don’t.

Other Benefits: Helps Depression, Lowers Triglycerides, Helps ADHD in Children, Lowers Blood Pressure, Inflammation, Lowers Cortisol (Stress Hormone), Helps Cognition (Blood Flow to Brain, Memory, Processing Accuracy), Reduces Liver Fat

How to take: 1-2 grams a day, 6g to reduce inflammation.

Toxicity: Fish Oil supplements might have mercury. After some studies, the lowest mercury concentration in fish was noted in salmon, trout, and shrimp so we recommend supplements coming from those sources.

WLI: Fish Oil doesn’t contribute to the weight loss process that much but itself, yet all its beneficial effects put the body at ease through stress relief, making dieting easier.

Don’t take if: You’re taking: contraceptive pills (they lower the absorption for fish oil), orlistat (lowers fish oil absorption), high blood pressure drugs (as fish oil lowers blood pressure as well, it might drop too much), blood clotting drugs: fish oil lowers blood clotting and taking it in combination with other types of drugs might determine bleeding and bruising.

The product below is the bestseller on Amazon. It has 2250 mg of fish oil and it provides a burpless experience. If you’ve had a past with “burpful” fish oil, I’m pretty sure you’ll love these.





#6 – Green Coffee

Green Coffee is just coffee beans that haven’t been roasted. As it has a high dose of Chlorogenic Acid, it has great benefits for fat loss and cardiovascular health. They’re not as amazing as Dr. Oz and others have promoted them to be, but it’s a good addition towards pound-shedding nonetheless.

Other Benefits: Lowers Blood Pressure, Lowers Fat Mass, Lowers Heart Rate, Increases Vascular Function

How to take: 600-800mg for a 50% Chlorogenic Acid Product – Best Dosage Unknown.

Toxicity: Allergies are possible

WLI: Over 12 weeks, an extra 2.47 kgs have been lost by those given 1g GCE daily (~500mg Chlorogenic Acid)

Do not take if: You are allergic to it, do some tests before you start using it.

#7 – Yerba Mate

Yerba Mate is a plant native to South America. It seems to be rich in caffeine, quercetin, chlorogenic acid and ursolic acid so it’s quite a cocktail of some of the 35 diet pills featured in this list. It has shown fat burning abilities during different studies. It mainly prevents the formation of fat cells while also increasing metabolism and suppressing appetite. Some of the studies say it burns fat during rest, while others that it does during exercise. Maybe we’re lucky and it does both!

It manages obesity through appetite suppression(in large doses) and fat oxidation(owed to the caffeine content).

Other Benefits: Lowers Heart Rate, Blood Glucose, and LDL-C(after 20 days of supplementation), Increases Bone Mineral Density (Strength) and HDL-C

How to take: Tea – 3 cups a day, Supplement: 1000-1500 mg a day

Toxicity: None noted

WLI: One Yerba Mate and one Placebo group were put ontoto a 12-week program, with the results of 150 cm3 shredded from the Yerba Mate group’s visceral fat while the Placebo group had an increase of 200 cm3

Don’t take if: Yerba Mate has a lot of major interactions, please consult your doctor before taking it or check this list

This is one of the few products available in capsule form. It has decent reviews, seems safe and qualitative. If you’re interested in the tea form, click the image and look at the related products.

#8 – Alpha-GPC

Alpha-GPC contains choline, a vitamin-like essential nutrient. Although it’s found in a wide variety of foods, it seems to exert its effects at higher doses than what the typical intake provides.

Due to its nootropic effects, it also seems to help Alzheimer’s disease to a mild to moderate extent. Alpha-GPC might also have an effect on our happiness levels, given that it has constantly raised serotonin levels after oral administration in both human and mice.

Most of the effects of Alpha-GPC are directed towards a better cognition and support a decent upgrade in performance. Although its great effects are not focused on fat burning, studies show it does promote fat burning 2 hours after consumption.

Other Benefits: Decreases Cognitive Decline, Increases Power Output, Increases Growth Hormone – Great choice for athletes.

How to take: 600mg for increased Power Output, 1200 mg for its effects on Cognition

Toxicity: None.

WLI: No specific studies.

Don’t take if: Safe.

This Alpha-GPC product offers the greatest price-to-quality ratio, with a decent dose for both starters and pros. Take 2 capsules daily for power output and 4 for cognition.

#9 – Eleutherococcus Senticosus

Also known as Siberian Ginseng, Eleutherococcus Senticosus is an adaptogenic herb which has been shown to increase work capacity during physically intense activities by preserving your body’s reserves. It also promotes fat oxidation. This combination of benefits is a great addition to any kind of cardio program, provided it offers you with longer workouts to burn your fat, and more fat burned.

WARNING! The methods used during the studies lacked regularly accepted protocol and conduit and therefore, their results might be unreliable. I would advise you to read other people’s reviews and determine if this supplement is worth buying.

Other Benefits: Lowers Blood Pressure, Cognitive Decline, Boosts Immunity, Anti-stress

How to take: 2-4g daily

Toxicity: None

WLI: Not known

Don’t take if: You have a heart condition or diabetes, as this supplement could interact with the medication.

This Eleuthero supplement by Now is one of the best-sellers, and also has good reviews. The 500mg dose allows you to customize your daily dose instead of going over the top before it’s the time to do so with a 1-2g dose, for example.

#10 – Spirulina

Spirulina is a blue-green algae. It is non-toxic. Besides packing a protein-punch with around 70% protein levels, it’s also quite rich in vitamin B12. It is used by numerous vegetarians as the main source of protein, and it has some great health benefits which make it a great supplement for a healthy regime.

It is generally used for its protective effects on the brain and reduction in liver fat.

Effects on the brain include stroke prevention and protection, protection against mineral toxicity and, of course, great prevention and even treatment of both Parkinson’s and Alzheimer’s disease. By prevention of neurodegeneration, spirulina also supports cognition in older people. Some limited evidence suggests that spirulina could also support neuronal regeneration while also reducing brain inflammation. Wow.

Digestive effects include the prevention of cholesterol absorption through spirulina supplementation.

Gym-goers should be aware of the fact that spirulina protein has shown better hypertrophy in some studies when compared to casein protein, so you might want to check into that.

Other Benefits: Lowers Triglycerides, Fights Allergies and their symptoms, Improves Muscular Endurance, Lowers Blood Pressure, Anti-Cancer Effects, Improves Insulin Sensitivity, Lowers Liver Fat, Lowers LDL (bad cholesterol), Raises HDL, Cardioprotection (heart tissue)

How to take: 5-8g to cover all effects

Toxicity: Mostly Safe, just make sure you take your supplements from a trusted firm because the plants might be contaminated.

WLI: 7% increase in weight loss compared to placebo.

Don’t take if: You’re taking immune system suppressants (having a transplant coming up or any kind of condition) – Spirulina boosts the immune system, therefore reducing the effects of the medication.

Although this is not the best-seller, the 1000mg concentration makes it much easier to reach the benefits, given that higher concentrations are needed for these to appear.

NOW is quite reliable as a supplement company, and their reviews are mostly good. They also offer the best price-to-quality ratio.





#11 – Ashwagandha

Ashwagandha is an herb used as an adaptogen in Ayurvedic medicine. It’s regarded to as the “king of Ayurvedic medicine”

Besides fighting anxiety, cancer, and neurodegenerative diseases, it also is a great addition to your diet with its fat-burning properties. By reducing cortisol and stress while boosting motivation, it will make sure you stay motivated and smiling during the rainy days and ecstatic during the sunny ones.

Being an adaptogen, it will make it much easier for you to get going with your diet and stick to it. An “adaptogen” is what makes your body and mind adapt easier and with less stress to new things you get going in your life. Shortly, it keeps you relaxed.

Adaptogens can be quite strong if you exaggerate with the dosage, so make sure you read the reviews to see how others are dealing with it because you don’t want to be a relaxed vegetable while having to drive to/from work. Play it safe!

Other Benefits: Anti-Cancer, Neuroprotection, Increases Testosterone, Sperm Quality, Social Functioning, and Well-Being, Lowers Depression, Lowers Fatigue, Lowers Blood Pressure, Improves Aerobic Capacity, Increases Power Output

How to take: Cost-effective: 300-500 mg a day – Optimal Dose for all the benefits: 6000 mg a day, divided into 3 doses

Toxicity: Large doses can cause an upset stomach, diarrhea, vomiting

WLI: 2% more weight loss compared to the placebo group

Don’t take if: You have any of these conditions: Pregnant, Diabetes, High or Low Blood Pressure, Ulcer, Auto-Immune Diseases, Upcoming Surgery (Might interfere with anesthesia)

What I love about this supplement is that it’s made with Organic Ashwagandha Root. You can’t put a price on safety for such an amazing supplement. Also, it consists of 1950 mg per dose, so it’ll be much easier for you to reach all the benefits given the upper limit you can reach with it.





#12 – 5-HTP

5-HTP is the precursor to serotonin, the neurotransmitter involved in triggering positive emotions. Besides lowering appetite and therefore contributing to weight loss, the happy-state it brings also helps by making this path easier to go along.

It is best suited for those who suffer from either mild, untreated depression or high degrees of inflammation, because both of these usually have lower levels of serotonin which 5-HTP can help towards pushing back.

If you’re one of those who have a lot of nightmares and sleep terrors, 5-HTP is helpful towards getting rid of them by elevation of serotonin levels.

WARNING: Do not take 5-HTP in combination with any medically prescribed antidepressant before consulting with your doctor. This combination can be LETHAL.

Other Benefits: Treats Addiction, Fights Depression, Stress and Anxiety, Improves Sleep, Fights Sleep Terrors

How to Take: 300-500 mg daily

Toxicity: Safe

WLI: Unknown, as fat loss is not the main focus of this supplement.

Don’t take if: You’re taking any other antidepressant drugs; this combination could be lethal. Black Cumin (Nigella Sativa)

200 mg is the biggest concentration available, and this is one of the best-sellers with great reviews. You can take 2 per day.

#13 – Black Cumin (Nigella Sativa)

Black Cumin is a spice frequently used in traditional medicine. Although it doesn’t have strong effects, it has many beneficial ones which make it a good tool to spice your diet with. Among them, of course, it’s been proven to promote weight loss by reducing appetite.

Other Benefits: Lowers Blood Pressure, Bad Cholesterol, Triglycerides, Fights Allergies, Treats Epilepsy, Soothes Pain, Boosts Immunity, Treats Asthma, Improves Pulmonary Function and Cognitive Function, Induces Well-Being State.

How to take: 250-1000 mg daily

Toxicity: None

WLI: Unknown

Don’t take if: Safe

Best price-to-quality ratio. A bestseller with great reviews and a decent concentration to help you adapt your body to the capsule usage, and then the capsule usage to your body’s needs.

#14 – 7-Keto DHEA

7-Keto DHEA has shown great promise in promoting fat loss in humans through an increase in metabolic rate. It’s fellow compound, DHEA, seems to be harmful. Make sure you do not confuse them with one another.

7-Keto DHEA was studied under a diet and exercise routine. The group taking 7-Keto DHEA lost 3 more 3kgs than those who didn’t. Keep in mind that studies are not clear if this effect happens whether you diet and exercise or not.

Therefore, the increase in fat loss using 7-Keto DHEA might depend on being on a healthy diet and exercise routine in order to take place.

Other Benefits: Nothing of note.

How to take: 200-400 mg daily divided in two doses

Toxicity: Safe

WLI: 2.88kg extra fat loss in comparison to the placebo group

Don’t take if: Safe

100mg is the strongest concentration found on Amazon. Take 2 caps daily. Although it’s quite expensive, Jarrow always delivers so at least we got that. This is the supplement I’m taking and have noticed a decent bump to my weekly weight loss (from 1kg/week to 1.5) for 3 weeks now.





#15 – Coleus Forskohlii

Coleus Forskohlii (also known as Forskolin) is an herb traditionally used in Ayurvedic Medicine. It has shown promising effects as a fat burner and testosterone-booster. Its effects are most suited for men.

Other Benefits: Lowers Asthma Symptoms, Strengthens Bones, Increases Lean Mass and Testosterone Levels, Increases HDL-C (Good Cholesterol)

How to take: 500 mg daily

Toxicity: Might provoke stomach acid in high doses

WLI: 2.8% BMI reduction compared to placebo

Don’t take if: You have an ulcer.

#16 – Eurycoma Longifolia Jack

Also known as Malaysian Ginseng, Eurycoma is an herb used as an aphrodisiac with pro-erectile and libido increasing effects. Although it’s mechanisms for fat loss are not completely known, progress has been noticed. It has also shown fantastic anti-estrogenic effects, putting itself forth as a top supplement for men.

Other Benefits: Lowers Cortisol and Stress, Increases Libido, Erectile Function, Sperm Quality, Sperm Motility, Power Output and Lean Mass.

How to take: 400-600 mg per day.

Toxicity: Doses over 1200 mg might affect the liver.

WLI: Not studied.

Don’t take if: Pregnant.

#17 – Grapefruit

Grapefruit is a tasty punch of active enzymes which promote fat burning by increasing metabolic rate. It has helped me throughout my weight loss journey and I must say, it’s a great supplement overall. Diet pills are usually called by its wonder compound name, Hesperidin.

Other Benefits: Improves Insulin Sensitivity, Lowers Bad Cholesterol

How to take: You can either go for the whole fruit scattered through the day, or choose a seed extract like the one below or Hesperidin supplements.

Toxicity: Has drug-drug interactions due to its powerful bio-actives, make sure you’re safe by checking them out.

WLI: Over 12 weeks, 1.1 more kg shredded through pills, 1.5kg through juice, 1.6kg through whole fruit.

Don’t take if: You’re taking any medication without making sure they don’t interact.

#18 – Gynostemma Pentaphyllum (Southern Ginseng)

This is an herb that shares only a few compounds to the Ginseng we all know, yet its handful of health benefits definitely put it in this category. It works by raising the metabolic rate, making sure you destroy those calories (and hence, fat cells) faster than you normally would.

Other Benefits: Increases Insulin Sensitivity, Lowers Blood Sugar, Lowers Insulin, Lowers Liver Enzymes

How to take: 6g as tea or 1.5 – 2g per day as capsules

Toxicity: Safe

WLI: Up to 8%

Don’t take if: Safe

#19 – Pterostilbene

Pterostilbene is kind of a better Resveratrol, with much better potency in most cases and better absorption. Having been only recently found, there are not many studies regarding it, yet the results look promising to say the least.

Other Benefits: Lowers Blood Pressure, Increases HDL-C while Lowering LDL-C, Improves Cognition and Fights Anxiety.

How to take: 50-150 mg twice a day

Toxicity: Safe

WLI: Unknown

Don’t take if: Safe

This is a gluten-free product. The price-quality ratio is pretty good. Although it’s at the upper, stronger limit, there should be no side effects. I would advise you to start with 1 capsule per day and go up from there.

#20. Rose Hip

Rose Hip is the fruit of Rosa Canina, and it’s usually used for joint health and osteoarthritis. Be that as it may, some weight loss during one study has been noticed. I cannot guarantee for this supplement, but it has some good benefits nonetheless, including an improvement in Skin Elasticity which helps if you have a lot of weight to shred and want to prevent loose skin.

Other Benefits: Lowers Blood Pressure, Alleviates Symptoms of Osteoarthritis and Rheumatoid Arthritis, Reduces Pain, Improves Skin Elasticity and Moisture, Reduces Wrinkles

How to take:0.5-10g per day taken with meals

Toxicity: Diarrhea and Loose Stools have been noticed at 40g daily

WLI:1 kg extra lost per month

Don’t take if: You have an upcoming surgery.

#21. Saffron

Saffron is one of the world’s most expensive spices, traditionally and mostly used to flavor foods. Lately, it has been studied more and more for its antidepressant and appetite suppressing properties. It seems to boost metabolism while also suppressing appetite. The downside is the way it plays with estrogen, potentially messing up both men and women. Wouldn’t recommend you taking this supplement for long periods of time. Although estrogen is great for women, it seems to be linked to breast cancer when there’s too much estrogen for too long. As always, play safely with every supplement you take.

Other Benefits: Fights Anxiety, Lowers Cortisol, Increases Estrogen (Good for Women, Bad for Men), Improves Sexual Function, Fights Symptoms of Alzheimer’s.

How to take: Up to 200mg daily

Toxicity: Safe

WLI: Unknown

Don’t take if: Safe

The featured product is one of the best sellers on Amazon. It consists of 88.5 mg of Saffron, so you can start from 1 per day and go up from there to 3 per day.

#22 – Yacon

Yacon, also known as the “diet potato” with the taste of a pear, is usually consumed as a syrup. Studies regarding it have shown some benefits towards intestinal health, with a slight appetite suppressing effect.

Other Benefits: Lowers Intestinal Motility, Improves Insulin Sensitivity, Lowers Bad Cholesterol

How to take: 10g per 70kg Syrup, 1g per day Capsules

Toxicity: Safe, but after doubling the dose, adverse effects such as intestinal pain and nausea were noted

WLI: Unknown

Don’t take if: Safe

#23 – Caralluma Fimbriata

Caralluma Fimbriata is a plant characteristic to India, and it is associated with appetite suppressing effects. Its effects seem to appear only after around 1 month of supplementation. Although other benefits are unknown, it’s a known-to-be great as an appetite suppressant. If that’s what you’re going for, I suggest you give it a chance.

Other Benefits: –

How to take: 1000 mg per day

Toxicity: Safe

WLI: Unknown

Don’t take if: Safe

#24 – Caffeine

I’m pretty sure you’re familiar with Caffeine’s effects, but there may be some still left unheard to you. Some drink it out of love, some use it out of need. Nonetheless, this supplement has some great benefits to bring to the table, including thermogenesis (hence making you burn fat) and mental stimulation. As a plus, pills offer you the same effect when you’re on the run. No waiting for the coffee to cool down, no palpitations if you drink it too fast. Just make sure you don’t get yourself close to a stroke by taking 5 at a time because you have an exam tomorrow. Guilty.

Other Benefits: Increases Running Capacity, Increases Power Output, Increases Testosterone, Increases Metabolic Rate, Improves Blood Flow, Improves Reaction Time

Downsides: Adrenaline Spike, Increases Blood Sugar Levels, Increases Blood Pressure, Increases Cortisol, Increases Heart Rate, Lowers Insulin Sensitivity

How to take: Start with 100 mg, build up to 200 mg for Fat Burning effects, 400 mg for Increasing Power Output.

Toxicity: Toxic above 1.8-3.6g. It gives dependence, also presents symptoms of withdrawal for up to 9 days which include: sleepiness, headaches, lack of motivation and more.

WLI: Burns an extra 12-32 kcals/hour (So for 4 hours of an increased metabolism daily, that translates in 560 kcal per week), yet it only works if paired with a healthy diet and exercise program. 24 weeks of 200 mg supplementation brought no fat loss alone.

Don’t take if: You have Heart Problems, Anxiety or Bipolar Disorder, Diarrhea, Epilepsy, or Diabetes.

The featured product offers you 200mg of Caffeine in one capsule. As a comparison, a normal coffee offers you 63mg of caffeine. If you’re sensitive to coffee and get palpitations after consumption, look for something with a lower concentration or a different supplement.

#25. Berberine

Berberine is extracted from a variety of herbs. Traditionally used in Chinese Medicine, it seems to have anti-diabetic effects, while also promoting weight loss by reducing the development of fat cells and increasing their usage. Make sure you don’t take these diet pills if you have diabetes, as they can mess up your blood sugar levels.

Other Benefits: Lowers Blood Sugar Level (Strong), Lowers Cholesterol, Lowers Insulin, Lowers Triglycerides, Increases Exercise Capacity, Increased Quality of Life, Increases Insulin Sensitivity

How to take: 900-2000 mg a day, divided into 3 doses. Take it with a meal, making sure your Blood Sugar

Toxicity: Overdosing can cause an Upset Stomach, Cramps, and Diarrhea.

WLI: Up to 13% decrease in Body Mass Index

Don’t take if: Pregnant, if you have Diabetes coupled with other medication, or if you have Low Blood Pressure. Not safe for children.

This product is one of the bestsellers on Amazon. It offers 1000mg of Berberine in one capsule, so start with one per day and go up from there when needed. If you’re prone to having an upset stomach, I would recommend you to start with a lower concentration for now.

#26. L-Carnitine

L-Carnitine and the related compound, Acetyl-L-Carnitine (ALCAR) has protective properties against the aging of mitochondria (a.k.a. the cell’s energy factory). It also promotes usage of fat cells as an energy source, therefore being a great fat burn agent. ALCAR only works for those who have a deficiency in it.

Other Benefits: Lowers Ammonia, Lowers Blood Sugar Levels, Lowers Fatigue, Improves Insulin Sensitivity, Reduces Muscle Damage, Treats Symptoms of Autism and ADHD in Children, Improves Attention, Increases Lean Mass, Reduces Muscle Soreness, Increases Cognition, Improves Erections, Lowers Heart Rate.

How to take: Between 500-2000 mg. ALCAR is usually used for its benefits on cognition (it’s regarded as a nootropic), while L-Carnitine is used for physical performance.

Toxicity: Safe

WLI: Although it has many ways to benefit weight loss, it seems that it only does whenever it’s deficient.

Don’t take if: You have Hypothyroidism or Seizures

#27. Green Tea Catechins

High amounts of Green Tea Catechins are found, of course, in green tea. This is a 4-molecule complex, of which EGCG is the most potent. This is also what we call a wonder-supplement due to its wide range of benefits, having effects on almost every system in the body. Besides these, it’s an amazing fat burner through thermogenesis and offers appetite suppression as well.

Other Benefits: Improves Good Cholesterol, Insulin Sensitivity, Lowers Blood Sugar, Lowers Blood Pressure, Improves Cognition, Lowers Heart Rate, Lowers Insulin Secretion, Lowers Muscle Soreness, Increases Oxygen Uptake, Protects Skin from UV, Improves Skin Quality, Lowers Carbohydrate Absorption, Protects the Heart, Neuroprotection, Anti-Obesity, Anti-Cancer, Protects the Liver, Protects against Diabetes

How to take: 400-500 mg for fat burning

Toxicity: Safe

WLI: 2.2 kg extra lost in 90 days

Don’t take if: Safe

This is one of the greatest blends regarding Green Tea Extract given its high concentration in EGCG, which is the one that gives us the benefits we’re looking for.





#28. Guarana

Guarana has a higher content of caffeine than coffee beans and its properties are mainly derived from this. It has shown promising results as a fat loss agent, yet studies are still unclear if this is due to any special compounds or the caffeine itself.

Other Benefits: Enhance Performance, Reduce Fatigue – both mental and physical, Stimulant

Toxicity: Same as Caffeine

WLI: Unknown

Don’t take if: Same as Caffeine

#29 – Melatonin

Melatonin is a hormone secreted by the brain to regulate sleep. Supplementation is mainly used to improve quality of sleep, but it brings great benefits including a slight reduction in BMI. This is most likely a side-effect caused by the better performance of the metabolism which is brought by a quality of sleep improvement.

Other Benefits: Treats Insomnia, Increases Gastrin (Better Digestion), Treats Stomach Ulcers, Fights Symptoms of Jet Lag, Lowers Blood Pressure, Lowers Cancer Mortality, Increases Leptin, Improves Sleep Quality, Treats Heartburn, Lowers Esophageal Pressure, Improves Blood Flow, Increases Growth Hormone, Improves Insulin Sensitivity, Improves Memory, Reduces Muscle Damage, Lowers Triglycerides.

How to take: 0.5 – 5 mg 30 min before bed. Growth hormone spikes often seen at 5 mg

Toxicity: Safe

WLI: Small BMI changes (0.2)

Don’t take if: You have diabetes, as it increases blood sugar; High Blood Pressure, Have Depression, Bleeding Disorders or an upcoming Transplant (increases immune function, your body may reject the organ)

We’re offering you the hammering option to melatonin, which is 5mg. This is also the concentration that brings growth hormone spikes, so it offers the best sleep quality and benefits.

#30 – Cissus Quadrangularis

Cissus Quadrangularis is used in traditional Ayurvedic medicine for bone and joint health, being capable to alleviate pain and decrease inflammation. Popular among athletes for these reasons, it has also shown signs of increasing weight loss to a degree.

Other Benefits: Lowers Triglycerides, Lowers Cholesterol, Reduces Pain, Increases Functionality in the Elder or Injured, Increases Serotonin

How to take: Between 600-3,600 mg depending on needs.

Toxicity: Safe

WLI: Unknown

Don’t take if: Safe

#31 – Fucoxanthin

Fucoxanthin is mostly found in brown seaweed, and it promotes weight loss with a delay due to the need of build-up inside the fat cells. Nonetheless, its results are quite promising and it might be a good supplement to add to your diet.

Other Benefits: Lowers Liver Fat, Improves Metabolic Rate, Lowers Blood Pressure, Lowers Triglycerides.

Downsides: Effects kick in after around 5 weeks, more or less depending on the individual and the degree of obesity.

How to take: 2.4 – 8 mg.

Toxicity: Safe

WLI: 5 kgs over 16 weeks with an 11% decrease in liver fat

Don’t take if: Safe

#32 – Yohimbine

Yohimbine is used as a fat-burning diet pill during fasting. Besides that, it’s an aphrodisiac and stimulant and helps improve sexual function. Works by increasing adrenaline levels in the body and lowering some regulation processes which usually suppress fat burning. On the downside, it interacts with many pharmaceutical drugs so you should take caution when using it.

Other Benefits: Improved Erections, Increases Penile Girth, Lowers Symptoms of Phobia

Downsides: Lowers Cerebral Blood Flow, Increases Heart Rate, Diarrhea, Increases Cortisol, Increases Anxiety, Stimulates Alcohol Dependence, Increases Blood Pressure.

How to take:2.5-5mg

Toxicity: Overdosing brings irregular heartbeats, while the recommended dosage provokes nausea, dizziness, abdominal pain, and nervousness.

WLI: 2% Fat Lost in 3 weeks

Don’t take if you have: Bleeding Disorders, Schizophrenia, Prostate Problems, Liver and Kidney disease, Any kind of Blood Pressure Disorder, Depression, Diabetes, Surgery Upcoming, Chest Pain or Heart Disease.

#33 – Licorice

Chinese Medicine traditionally uses Licorice to treat digestive problems, while also increasing the quality of life. Supplementation has had great results towards weight loss, yet it does bring its downsides. Make sure you don’t abuse this supplement, doing so has led to death.

Other Benefits: Treats Canker Sores

Downsides: Increases Cortisol, Increases Blood Pressure, Lowers Testosterone, Lowers Oxidation of Bad Cholesterol

How to take: 150-500 mg daily

Toxicity: Safe as long as you stay in the recommended dosage. One death noted in a woman that exclusively ate Licorice. Might make you feel uneasy or tired.

WLI: 10% Reduction in body fat in 2 months at 3.5g daily (be careful)

Don’t take if you are: Pregnant or have a Heart Condition, High Blood Pressure, Hypotonia, Low Potassium, Kidney Disease, Sexual Problems (Licorice lowers libido)

#34. Leptin, Ghrelin, Adiponectin Tri-Metabolic Control

These three hormones regulate your food intake, from how hungry you are to your actual eating habits. They also decide how fast your metabolism needs to be and regulate it accordingly.

Leptin is the hormone that also provokes the great weight loss at the beginning of a diet, only to slow it down later on. It tracks your metabolism AND your caloric intake and decides if the metabolism should work harder or slower to cope with the way you’re eating. Its levels spike through a fatty/carb-filled meal, and that’s why cheat meals work really well.

Now, this is more of an honorable mention but it does deliver very well. I’ve had a leap of faith towards it and decided to buy this product and was quite amazed at the results. I usually pumped my leptin up through weekly cheat meals and while they did help, they would also damage my Calories In/Calories Out ratio, therefore one or two days of the week would end up unproductive.

This supplement does not contain leptin, adiponectin and ghrelin. It’s just a mix of supporters towards these hormones.

#35. Turmeric & Curcumin

Last but not least, we have the amazing turmeric with Curcumin. Now, I’ve done an extensive review on this amazing product and I’ve also used it for quite a while to say it delivers.

In a nutshell, Turmeric is an anti-inflammatory and anti-oxidant supplement that provides you with an nourishment to your body. It brings better body balance and therefore, fewer cravings and more of an easy journey towards your fat loss.

Bioperine is patented black pepper, which helps turmeric’s main functional component, curcumin, get absorbed. Curcumin is quite hard to get absorbed by itself, so Bioperine hops in to help.

Other Benefits: Reduced Depression and Anxiety, Reduced Risk of Colorectal Cancer, Anti-Oxidant and Anti-Inflammatory supplement, Improves Cognition and Functionality in Elders or Injured

Toxicity: Safe

Weight Loss Pills That Actually Work – Conclusion

Well, this has been quite an extensive list!

Now, remember, feel safe to buy any of the products listed above as everything I wrote is based on the results of ACTUAL studies and research, not some made-up attempt at marketing these better.

Also, I can’t stress this well enough: these supplements will not exponentially help you lose weight if you don’t change your lifestyle and start holding on to a decent diet and preferably, exercise regime.

You have no excuse for not trying at least. You cannot lose 10 lbs in 2 days, no matter what others say. Be healthy, be consistent, and the results will change your life. Don’t be, and you’ll stay the same.

If you choose a path, stick to it no matter what. If you feel like you tried everything without any result, consult with a specialist that will tune your diet towards results. There might be unsuspected, hidden calories in what you’re eating. (Trust me, I saw 1500 calories salads. Everything is possible in today’s world.)

If you don’t want to go to a specialist, hold on to your diet for one month. If that doesn’t work, lower your daily caloric intake and try again.

I can also recommend you a great program I’ve recently come across – The Fat Burning Fingerprint. What I like about it is the way it focuses on offering your metabolic type a suitable diet for its needs, something rarely seen in today’s programs. You can find an extensive review of it by clicking here.

All the best,

Frank.

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