A police officer has been killed while on an annual motorcycle ride, which set off from Melbourne on Friday to honour officers who have died in the line of duty.

The Age understands a senior sergeant from Melbourne's bayside area was killed after a car travelling west along the Princes Highway at Mount Raymond Regional Park near Orbost veered onto the opposite side of the road about 2.20pm.

He was on the annual Wall to Wall ride with his son, who is also a police officer.

It's believed the veteran police officer was riding on his motorcycle alongside his son when they saw the car driving erratically on the wrong side of the road.

Further details of the crash are yet to be confirmed, but the senior sergeant died at the scene.