Twitter and Instagram users lampooned Ted Cruz Tuesday night for accidentally elbowing his wife Heidi in the face, moments after dropping out of the presidential race.

The Texas senator hugged her after his concession speech before jabbing his finger into her face and hitting her with his elbow as he embraced his father Rafael.

An Instagram user posted a video of the awkward moment on Instagram, captioning it: 'When you're the Zodiac killer and you want to murder your wife but everyone is watching so you elbow her in the head instead.'

She was referring to a meme dating back to March 2013, when someone on Twitter joked for the first time that Cruz was the serial killer who claimed to have murdered 37 people and had five confirmed victims in California in the 1960s.

Instagram and Twitter users made fun of Ted Cruz Tuesday night for accidentally elbowing his wife Heidi in the face while hugging his father Rafael after his concession speech

Cruz awkwardly jabbed his finger into his wife's face before hitting her with his elbow as he embraced his father, prompting Kate Bennett to say she had taken the loss 'harder than anyone - in the face'

A woman lamented: 'And poor Heidi Cruz takes the loss harder than anyone - in the face.'

More people exploited the Zodiac killer line to poke fun at Cruz, with one of them circling letters spelling out 'Zodiac' in a headline that read: 'Ted Cruz to drop out of presidential race' and wondering what the senator was going to do next.

Another Twitter user asked: 'Anyone else having a hard time making sense of the transcript of Cruz's concession speech?' and attached a picture of one of the cryptograms sent to the police by the killer at the time of the murders.

Someone else found it strange that Cruz would drop out of the race 'just as the Zodiac speculation intensified', when one joke read like a headline announcing: 'For the first time in 47 years, the Zodiac killer has taken a new victim - Ted Cruz's campaign'.

One Twitter user went as far as saying: 'I feel bad for Ted Cruz, who was going to restore the sanctity of the Oval Office with a ritual Zodiac killing'.

Plenty of users exploited the Zodiac killer line to lampoon Cruz, referring to a meme dating back to March 2013, when someone on Twitter joked was the serial murderer

One Twitter user posted this photo of one of the cryptograms sent to the police by the Zodiac killer at the time of the murders, referring to it as 'the transcript of Cruz's concession speech'

Someone else found it strange that Cruz would choose to drop out of the presidential race 'just as the Zodiac speculation intensified'

One joke read like a headline announcing: 'For the first time in 47 years, the Zodiac killer has taken a new victim - Ted Cruz's campaign'

One Twitter user went as far as saying: 'I feel bad for Ted Cruz, who was going to restore the sanctity of the Oval Office with a ritual Zodiac killing'

Someone made use of the Crying Jordan meme, which features a photo of the former Chicago Bulls player in tears during his 2009 induction at the Basketball Hall of Fame

Carly Fiorina, who became Cruz's running mate less than a week before he dropped out of the race, was not spared by Tuesday's jokes.

Someone on Twitter said ironically the former HP CEO had had 'a major impact' on Cruz's campaign.

Another user poked fun at the pair, saying they would 'melt' if they were left out in the sun.

Reflecting on the whole campaign, one posted an elaborate chart inspired by the NCAA March Madness, showing how Trump and Kasich had come to be the final two contenders for the GOP nomination.

The user, Daniel Donner, titled the chart the '2016 March To Madness'.

Another person, with the Twitter handle @TheGoodGodAbove, praised Cruz for dropping out, adding: 'For once in your life, you listened to God.'

A woman noted the Cruz ship had 'gone down like the Titanic'.

And a man tweeted: 'Smart of Cruz to announce his dropout at a podium instead of his original plan, which was to whisper it into every voter's ear as they slept.'

Someone made use of the Crying Jordan meme, which features a photo of the former Chicago Bulls player in tears during his 2009 induction at the Basketball Hall of Fame.

They replaced Cruz with a cutout of Jordan in a photo of the concession speech.

Carly Fiorina, who became Cruz's running mate less than a week before he dropped out of the race, was not spared by Tuesday's jokes

One user poked fun at Cruz and Fiorina, saying they would 'melt' if they were left out in the sun. Another said ironically the former HP CEO had had 'a major impact' on Cruz's campaign

Another posted this elaborate chart inspired by the NCAA March Madness, showing how Trump and Kasich had come to be the final two contenders for the GOP nomination

One person, with the Twitter handle @TheGoodGodAbove, praised Cruz for dropping out, adding: 'For once in your life, you listened to God'

Some users reacted to Cruz's announcement with puns, such as this woman who noted the Cruz ship had 'gone down like the Titanic'

Patrick Monahan praised Cruz for announcing his dropout in a traditional way on a podium, instead of whispering it 'into every voter's ear as they slept'

Many also poked fun at John Kasich for staying in the race against Donald Trump.

Some made references to the voracious appetite displayed by the Ohio governor on the campaign trail.

One user saying someone ought to 'pull Kasich out of that deli in the Bronx where he lives now to tell him the news'.

But someone else said the governor would never drop out of the race before a visit at In-N-Out Burger, which operates on the West coast.

A woman posted a photo of Patrick, the voracious starfish in Spongebob Squarepants, inhaling dozens of Krabby Patties with the caption: 'Kasich is too busy eating his way to California in free campaign food to bow out now.'

Buzzfeed reporter Andrew Kaczynski pictured Kasich looking up while eating a sandwich, pointing to himself and saying with his mouth half full: 'Me?'

Yahoo News editor Colin Campbell had a different vision and imagined the governor putting on his headphone to listen to Eminem's 'Lose Yourself'.

Many also poked fun at John Kasich for staying in the race against Donald Trump, some making references to the voracious appetite displayed by the Ohio governor on the campaign trail

Someone said the Ohio governor would never drop out of the race before a visit at In-N-Out Burger, which operates on the West coast

A woman posted a photo of Patrick, the voracious starfish in Spongebob Squarepants, inhaling dozens of Krabby Patties, saying Kasich was too busy eating on the campaign trail to drop out now

Buzzfeed reporter Andrew Kaczynski pictured Kasich looking up while eating a sandwich, pointing to himself and saying with his mouth half full: 'Me?'