Summary: A new study in Scientific Reports concludes human herpesvirus 6 may impair the brain’s ability to repair itself in demylination diseases, such as multiple sclerosis. HHV-6 is the most common human herpes virus, with an estimated 80% of people being exposed to infection during childhood. Researchers found the virus produces a protein that can impair the ability of brain cells to repair damaged myelin.

Source: University of Rochester Medical Center.

The ubiquitous human herpesvirus 6 (HHV-6) may play a critical role in impeding the brain’s ability to repair itself in diseases like multiple sclerosis. The findings, which appear in the journal Scientific Reports, may help explain the differences in severity in symptoms that many people with the disease experience.

“While latent HHV-6 — which can be found in cells throughout the brain — has been associated with demyelinating disorders like multiple sclerosis it has not been clear what role, if any, it plays in these diseases,” said Margot Mayer-Proschel, Ph.D., an associate professor at the University of Rochester Medical Center Department of Biomedical Genetics and co-author of the study. “These findings show that, while in the process of hiding from the immune system, the virus produces a protein that has the potential to impair the normal ability of cells in the brain to repair damaged myelin.”

It is estimated that more than 80 percent of people have been exposed to HHV6 at some point during their early childhood. HHV-6 is the most common human herpesvirus and infections that occur during childhood often go unnoticed but the virus can cause roseola, which is characterized by a fever and rash in infants. A much smaller number — one percent of people -have congenital HHV6 where a single copy of the virus is acquired through either the father’s sperm or mother’s egg and is passed on to the developing child.

While the immune system fights off the most active forms of the infection, the virus never truly leaves our bodies and can reactivate later in life. The herpesvirus 6 accomplishes this form of latency by integrating itself into our genetic code and thus hiding in cells and evading the immune system.

One of the first studies to show an association between latent HHV-6 infection and demyelinating disorders was conducted in 2003 by URMC researchers David Mock, M.D., who is a co-author of the current study, Andrew Goodman, M.D. and others. They noted that HHV6 genetic code could be found in the brain cells of individuals with severe forms of multiple sclerosis.

Viruses have long been suspected to contribute to multiple sclerosis, a disorder in which the body’s own immune system attacks and destroys myelin — the fatty tissue that insulates the connections between nerve cells. However, while the 2003 study indicated that the herpes virus played some role in multiple sclerosis, it has subsequently become clear that the virus is unlikely to trigger the disease.

The Rochester researchers in the current paper took a new approach and asked instead whether the virus could have an impact on a critical support cell found in the brain called oligodendrocyte progenitor cells (OPCs). These cells play an important role in maintaining the brain’s supply of myelin. When myelin is lost to disease, age, or injury, OPCs are activated, migrate to where they are needed, and mature into myelin-producing cells which repair the damage.

The researchers examined the impact of the latent HHV-6 on the activity of human OPCs, which was possible through the work of Chris Proschel, a co-author of the manuscript with expertise in the generation of human OPCs. One of the ways the virus stays hidden in cells is by expressing a protein called U94 that helps it keep its place in the human DNA and remain undetected from the immune system. By studying human cells and transplanting human OPCs into animal models, the team discovered that when U94 was expressed in OPCs, the cells stopped migrating to where they were needed.

What is still not fully understood is the relationship between the extent of the viral infection in the brain and the severity of diseases like multiple sclerosis and other demyelinating diseases such as leukodystrophies and Vanishing White Matter disease. For example, do the number of infected cells need to reach a certain threshold before OPC function is impeded? Are individuals who have congenital HHV6 more vulnerable to severe forms of these diseases?

“More research is needed to understand by which mechanisms the virus impedes the function of OPCs and what impact this has on the progression of these diseases,” said Mayer-Proschel. “But it is clear that HHV6, while not necessarily the cause of demyelinating diseases, is limiting the ability of the brain to repair damage to myelin thereby potentially accelerating the progression of these diseases.”





About this neuroscience research article

Additional authors of the study include Andrew Campbell, Jessica Hogestyn and Brittany Lopez with URMC and Christopher Folts with Harvard Medical School.

Funding: The study was supported with funding from National Multiple Sclerosis Society, the New York State Department of Health, and the Link Foundation.

Source: Mark Michaud – University of Rochester Medical Center

Image Source: NeuroscienceNews.com image is credited to the National Cancer Institute.

Original Research: Full open access research for “Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration” by Andrew Campbell, Jessica M. Hogestyn, Christopher J. Folts, Brittany Lopez, Christoph Pröschel, David Mock & Margot Mayer-Pröschel in Scientific Reports. Published online June 21 2017 doi:10.1038/s41598-017-04432-y

Cite This NeuroscienceNews.com Article

[cbtabs][cbtab title=”MLA”]University of Rochester Medical Center “Hidden Herpes Virus May Play Role in Multiple Sclerosis and Other Brain Disorders.” NeuroscienceNews. NeuroscienceNews, 10 July 2017.

<https://neurosciencenews.com/hhv6-herpes-ms-7050/>.[/cbtab][cbtab title=”APA”]University of Rochester Medical Center (2017, July 10). Hidden Herpes Virus May Play Role in Multiple Sclerosis and Other Brain Disorders. NeuroscienceNew. Retrieved July 10, 2017 from https://neurosciencenews.com/hhv6-herpes-ms-7050/[/cbtab][cbtab title=”Chicago”]University of Rochester Medical Center “Hidden Herpes Virus May Play Role in Multiple Sclerosis and Other Brain Disorders.” https://neurosciencenews.com/hhv6-herpes-ms-7050/ (accessed July 10, 2017).[/cbtab][/cbtabs]

Abstract

Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration

Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may contribute to inadequate myelin repair after injury.

“Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration” by Andrew Campbell, Jessica M. Hogestyn, Christopher J. Folts, Brittany Lopez, Christoph Pröschel, David Mock & Margot Mayer-Pröschel in Scientific Reports. Published online June 21 2017 doi:10.1038/s41598-017-04432-y

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