Before Abbi Jacobson and Ilana Glazer descended into the Union Square subway station one chilly Wednesday morning, they made it clear they were not hoping for any outrageous interactions that could be spun into material for “Broad City,” their Comedy Central series.

Speaking of past experiences with unpredictable straphangers and pungent subterranean odors, Ms. Jacobson said, “They’re usually not positive, right? Every once in a while, someone does something really nice for somebody else.”

Ms. Glazer added, “But usually it’s gross.”

With a bit more fortitude and a shared sense of humor that is seemingly unshockable, Ms. Jacobson, 30, and Ms. Glazer, 27, the creators and stars of “Broad City,” made it a surprise hit in just one season. In 10 episodes shown last year, it offered an absurdist, slapstick look at two women scraping by in New York. They have each other’s backs through apartment lockouts, minor drug deals and the occasional hurricane, and it becomes clear they care far more about getting into a Lil Wayne concert than getting anywhere on the ladder of life.

Its exaggerated but deeply felt presentation of the real-life friendship between Ms. Jacobson and Ms. Glazer has brought “Broad City” a devoted following on a cable channel better known for the political satire of “The Daily Show” and the dude-bro antics of “Tosh.0” and “Workaholics” and earned it a second season, which begins on Wednesday.