Story highlights Collins is the first Republican to break ranks over Pruitt

"Mr. Pruitt and I have fundamentally different views of the role and mission of the EPA," she said

Washington (CNN) Maine Republican Sen. Susan Collins said Wednesday she will vote against President Donald Trump's pick for Environmental Protection Agency administrator, Scott Pruitt.

Collins -- who voted against the confirmation of Education Secretary Betsy DeVos and, according to sources , indicated she was likely to vote against Andrew Puzder for labor secretary before he withdrew Wednesday -- is the first Republican to break ranks over Pruitt.

"The fact is, Mr. Pruitt and I have fundamentally different views of the role and mission of the EPA," Collins said in a statement

Collins did say, however, she would vote to invoke cloture on Pruitt's nomination, which would help clear him from the threat of a filibuster.

Republicans currently hold a 52-48 majority in the Senate, with Vice President Mike Pence holding a tie-breaking vote. A source told CNN that West Virginia Democratic Sen. Joe Manchin will likely support Pruitt.

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