Refaquin contains Hydroquinone 4% + Tretinoin 0.05% + Fluocinolone Acetonide 0.01%

Exp Date: 18 months since your purchase date.











Hydroquinone is classified therapeutically as a depigmenting agent. Tretinoin is classified therapeutically as a keratolytic. Floucinolone Acetonide is classified therapeutically as an anti-inflammatory.

One of the components in Refaquin cream, hydroquinone, is a depigmenting agent, and may interrupt one or more steps in the tyrosine-tyrosinase pathway of melanin synthesis. However, the mechanism of action of the active ingredients in Refaquin cream in the treatment of melasma is unknown.

Refaquin cream is indicated for the short-term treatment of moderate to severe melasma of the face, in the presence of measures of sun avoidance, including the use of sunscreens.

Refaquin cream, a combination drug product containing corticosteroid, retinoid, and bleaching agent, is not indicated for the maintenance treatment of melasma. The safety and efficacy of Refaquin cream in the treatment of hyperpigmentation conditions other than melasma of the face have not been studied.