Mercury 4 (1961) NASA's second suborbital mission was a success until after splashdown, when the hatch blew unexpectedly, forcing pilot Gus Grissom to egress into the water as the capsule began to sink.

Gemini 3 (1965) The mission that performed the first orbital maneuvers by a crewed spacecraft, and which was the first crewed flight of the Gemini spacecraft.