A crash between a bus and a car in Auckland's city centre has left one person seriously injured on Friday evening.

A crash between a bus and a car has blocked a major intersection in central Auckland and left one person seriously injured and three others with minor injuries.

A police spokeswoman said the crash happened at 7.47pm on Friday, at the intersection of Queen St and Victoria St West.

One person in the car had been taken to hospital with serious injuries, the police spokeswoman said.

DILEEPA FONSEKA/STUFF One person is seriously injured after a crash in Auckland's CBD.

Taxi driver Bozhur Rahman was standing at the corner of the intersection outside Farmers department store at the time of the crash.

Rahman was near the scene but looking away from the intersection when the crash occurred.

He said he heard a "boom" then saw a white Mercedes Benz had crashed head-on into a green Inner Link bus.

When an ambulance came they removed the driver who Rahman said was a man in his fifties or sixties who was clutching his chest.

St John spokesman Gerard Campbell said four people were injured in the crash and taken to Auckland City hospital.

Three of those people were taken to hospital with minor injuries.

DILEEPA FONSEKA/STUFF Police were at the scene of a crash between a bus and a car in Auckland's CBD on Friday evening.

An additional person was treated for injuries at the scene, Campbell said.

A police spokesperson said the scene of the crash had been cleared by 9.44pm Friday but motorists could still expect delays.

A Fire and Emergency NZ spokeswoman said two fire trucks attended the crash.