a, Analysis procedure with a random quarter of all trials (i.e. 4 to 5 trials) during the standard 4-lap experiment removed, for each mouse. Left: Percentage of previously statistically significant ESR cells that retained their statistical significance (70% = 726/1055 ESR cells, n = 14 mice) compared to previously non-ESR cells that became significant (5% = 131/2451 cells, same animals). Middle and Right: Pearson correlation of ESR activity and spatial activity across days in the standard 4-lap experiment. See Fig. 2(e) for description and methods. (500 cells total). b, ESR correlations between even numbered trials vs odd numbered trials of individual cells, as an indicator for the robustness of ESR patterns between trials. See Fig. 2(e) for description and methods. (611 cells total). c, Standard analysis procedure conducted on the standard 4-lap experiment (see Methods)—albeit with a smaller spatial bin size (6.25 cm x 5 cm). Left: Summary statistics: Percentage of ESR cells in the whole CA1 pyramidal population that were tuned to lap 1, 2, 3, or 4, on a single day in the standard 4-lap experiment (n = 14 animals, 3506 cells). Center and Right: Pearson correlation of ESR activity and spatial activity across days in the standard 4-lap experiment (n = 8 animals, 566 cells). d, The distribution of ESR correlations when cell identities were shuffled across day 1 vs 2 on the standard 4-lap task (n = 8 mice). e, Lap 1, 2, 3, and 4 ESR cells were significantly preserved over days during the standard 4-lap task, even with different thresholds for highly preserved ESR cells. χ2 and p values are shown in the Figure (622 cells total). f, Pearson correlation of ESR activity across days during the standard 4-lap task, calculated using the subpopulation of ESR cells that were active in the main spatial bin during at least 1/2 of all the trials (327 cells total).