The song dethrones Ed Sheeran's "Shape of You." Plus, another new top 10 for Lamar and a pair from the tandem of Zedd & Alessia Cara and triple team of Luis Fonsi, Daddy Yankee & Justin Bieber.

Kendrick Lamar's "Humble." rises from No. 3 to No. 1 on the Billboard Hot 100 chart (dated May 6), becoming the rapper's second Hot 100 No. 1 and first as a lead artist. The song unseats Ed Sheeran's "Shape of You" after 12 weeks atop the Hot 100.

Meanwhile, three songs enter the Hot 100's top 10, led by Lamar's "DNA.," the chart's top debut at No. 4, from the rapper's new album DAMN., which enters at No. 1 on the Billboard 200 chart. Plus, Zedd and Alessia Cara's "Stay" jumps from No. 14 to No. 7 and takes over as the top-selling song of the week, and Luis Fonsi and Daddy Yankee blast 48-9 with "Despacito," following the release of its remix with newly-added featured artist Justin Bieber.

As we do every Monday, let's run down the top 10 of the Hot 100, which blends sales, airplay and streaming data. All charts will update on Billboard.com tomorrow, April 25.

"Humble.," released on Top Dawg/Aftermath/Interscope Records, becomes the 1,062nd No. 1 in the Hot 100's history (which dates to Aug. 4, 1958) and Lamar's second, and first as a lead act. He first topped the June 6, 2015-dated chart as featured on Taylor Swift's "Bad Blood."

"Humble." surpasses its prior No. 2 Hot 100 high, set upon its debut two weeks ago. The track spends a third week at No. 1 on Streaming Songs, up 56 percent to an astounding 67.4 million U.S. streams in the week ending April 20, according to Nielsen Music (good for the Hot 100's top Streaming Gainer award). Only one song has posted a greater weekly total on Streaming Songs (which originated on March 2, 2013): Baauer's "Harlem Shake," which peaked with 103 million, powered heavily by user-generated clips featuring the song's audio, the week that the survey debuted. Notably, in between "Harlem" and "Humble.," Adele's "Hello" posted the highest weekly streaming sum: 61.6 million, in its first week (Nov. 14, 2015).

"Humble." also leads the audio subscription services-based On-Demand Streaming Songs chart for a third frame with the highest weekly total (43.5 million on-demand U.S. streams) in the chart's history (handily passing the 36.2 million logged by Drake's "One Dance," featuring WizKid and Kyla, as reflected on the May 21, 2016, chart). It drops 5-10 on Digital Song Sales (56,000 downloads sold, down 3 percent, in the week ending April 20) and debuts at No. 47 on Radio Songs (28 million in airplay audience, up 26 percent, in the week ending April 23).

"Humble." tops the Hot Rap Songs chart for a third week and returns for a second week atop Hot R&B/Hip-Hop Songs (2-1).

As previously reported, Lamar's LP DAMN., which includes "Humble.," vaults onto the Billboard 200 with the biggest week for an album in 2017 (603,000 equivalent album units). Meanwhile, the set's "DNA." debuts on the Hot 100 at No. 4, powered by its No. 2 entrance on Streaming Songs (51 million). Thanks to "Humble." and "DNA.," Lamar is the first act to double up in the Hot 100's top five simultaneously since Bieber in October; The Chainsmokers earned the honor earlier the same month.

Despite dipping to No. 2 on the Hot 100, Sheeran's "Shape" adds an 11th week at No. 1 on Radio Songs (184 million, down 1 percent). It drops 2-4 on Streaming Songs (39.5 million, down 5 percent) and 3-6 on Digital Song Sales (66,000, essentially even week-over-week). The song led the rankings for four and 10 weeks, respectively.

And, more honors to offset the departure of "Shape" from the Hot 100's summit: the song becomes Sheeran's second No. 1 on the Adult Contemporary airplay chart (following "Thinking Out Loud," which topped the tally for 19 weeks in 2015). "Shape" crowns the Adult Pop Songs airplay chart for a ninth week and Dance/Mix Show Airplay for a sixth frame. It vacates the top spot on Pop Songs after nine weeks at No. 1 and led Dance Club Songs for two frames.

Along with Lamar and Sheeran in the Hot 100's top four spots, Bruno Mars' "That's What I Like" descends to No. 3 from its No. 2 high (after four total weeks in the runner-up rank). It keeps at No. 2 on both Radio Songs (160 million, up 6 percent) and Digital Song Sales (80,000, up 9 percent). "Like" leads the Hot R&B Songs chart for a 10th week and hits No. 1 on Pop Songs; it's Mars' eighth Pop Songs leader, tying him with Justin Timberlake for the most among male soloists (dating to the chart's 1992 start).

Future's highest-charting Hot 100 hit, "Mask Off," enters the top five (7-5). Driven by the #MaskOffChallenge meme, in which everyone from dancers to violinists and flute players accompany the song in user-generated clips, the track stays at No. 3 on Streaming Songs (38.5 million, up 5 percent). Directly below on the Hot 100, KYLE's debut hit "iSpy," featuring Lil Yachty, is steady at No. 6 after previously rising to No. 4.

Zedd and Cara's "Stay" surges 14-7 on the Hot 100 (as the chart's top digital sales gainer) and bounds 10-1 on Digital Song Sales (up 135 percent to 91,000 sold), aided during the tracking week by 69-cent sale-pricing in the iTunes Store and the April 18 arrival of its official proper video. The collab is each act's first Digital Song Sales No. 1 and third Hot 100 top 10. Zedd previously hit the Hot 100's top 10 with "Clarity," featuring Foxes (No. 8, 2013), and as featured on Ariana Grande's "Break Free" (No. 4, 2014); Cara had tallied the top 10s "Here" (No. 5, 2016) and "Scars to Your Beautiful" (No. 8, two months ago). "Stay" also soars 5-1 on the Hot Dance/Electronic Songs chart, where it's Zedd's third No. 1 and Cara's first.

"Stay" with us for more: the song's ascent to the Hot 100's top 10 returns a female soloist to the region after a very noticeable one-week break; a week ago, no solo women charted in the Hot 100's top 10 for the first time in more than 33 years. The track is also the fourth song titled simply "Stay" to hit the Hot 100's top 10. It follows top-10 stays for hits by Maurice Williams & The Zodiacs (No. 1, one week, 1960); Shakespear's Sister (No. 4, 1992); and Rihanna, featuring Mikky Ekko (No. 3, 2013).

The Chainsmokers and Coldplay's "Something Just Like This" slides 5-8 on the Hot 100, after reaching No. 3. Still, the song adds top Airplay Gainer honors on the Hot 100 (up 22 percent to 100 million in audience, as it pushes 5-3 on Radio Songs). Plus, The Chainsmokers have now spent 51 consecutive weeks in the Hot 100's top 10 (dating to May 21, 2016, and encompassing four top 10s), tying Drake, in 2015-16, for the second-longest streak of ranking in the bracket consecutively; Katy Perry linked a record 69 straight weeks in the Hot 100's top 10 in 2010-11.

Fonsi and Daddy Yankee's "Despacito," featuring Bieber, rockets 48-9 on the Hot 100 following the April 17 arrival of its new Bieber-assisted remix and video. Sales account for slightly more than half the song's points on the Hot 100, as it re-enters Digital Song Sales at a new No. 8 high, exploding 510 percent to 60,000 sold; prior to Bieber's involvement, the song had reached No. 48 on the sales chart (and No. 44 on the Hot 100) and sold as many as 15,000 in a week. The track also flies 33-14 on Streaming Songs (24.1 million, up 129 percent) and enters Radio Songs at No. 39 (30 million, up 25 percent).

"Despacito" (which translates to "slowly" in English) is the first Hot 100 top 10 for both Fonsi and Daddy Yankee. The former had reached the chart with two prior titles in 2005 and 2008, peaking as high as No. 90; the latter had neared the top 10, peaking at No. 12 as featured (with Nina Sky, Gem Star and Big Mato) on N.O.R.E.'s "Oye Mi Canto" in 2004. Bieber adds his 12th Hot 100 top 10.

Until "Despacito," what was the last mostly-Spanish-language song to enter the Hot 100's top 10? We have to dance all the way back to 1996 for Los Del Rio's pop-culture juggernaut, and 14-week No. 1, "Macarena" (powered by its Bayside Boys remix). "Despacito" additionally tops the Hot Latin Songs chart for a 12th week.

Rounding out the Hot 100's top 10, Lil Uzi Vert's "XO TOUR Llif3" slides from its No. 8 highpoint to No. 10, while holding at No. 5 on Streaming Songs (34.7 million, up 5 percent). Like Future's "Mask Off," "TOUR" is fueled by viral buzz, specifically the #LilUziVertChallenge, which is based on a shoulder-shimmy dance performed by the rapper and has prompted fan-made videos across social media.

Find out more Hot 100 news in the weekly "Hot 100 Chart Moves" column and by listening (and subscribing) to Billboard's Chart Beat Podcast and Pop Shop Podcast, all posting this week. Plus, visit Billboard.com tomorrow (April 25), when all charts, including the Hot 100 in its entirety, will refresh.