-A curious adult from Ireland March 25, 2015 Because you and your sister are identical twins, you pretty much have the same DNA. Not exactly but pretty darned close. This is because you both started from the same fertilized egg. Which is why identical twins are also called monozygotic. Since you both have the same DNA, this is almost like the two sets of children have the same moms but different dads. In fact, this is why at the DNA level they are really more like half siblings instead of first cousins. They share 25% of their DNA (and genes) instead of the usual 12.5%. Legally your kids and your sister’s kids are first cousins but at the DNA level they are half siblings. They share twice as much DNA as run of the mill first cousins! What I thought I’d do for the rest of the answer is go into a bit more detail about why you and your sister’s kids share 25% of their DNA. As you’ll see, it has to do with how DNA is passed on. Cousins Who Share 25% of Their DNA We get half our DNA, or genetic information, from our mom and half from our dad. This DNA comes in packages called chromosomes. Most people have 46 chromosomes arranged in 23 pairs. When we get our DNA from our parents, we inherit one chromosome from each of their pairs. This is what it may look like for any given pair:

In this picture, each chromosome is represented by a rectangle. Dad has a dark blue chromosome and a light blue one while mom has a pink and a red one. In this case the child got a light blue one from dad and a red one from mom. The child could also have instead ended up with the dark blue and/or the pink. If only it was that simple! Chromosomes are almost never passed down whole. Instead, parent chromosomes in each pair swap DNA with each other while forming sperm and egg cells. This process is called recombination. Here is something closer to reality: Instead of getting an all dark blue or light blue chromosome from dad, the child got a mix of the two. Same thing with mom. This is actually just one of the many possible combinations. Recombination can happen at any place along a chromosome leading to infinite color combinations! For identical twins (like you and your sister), their chromosome patterns should be identical like this: The two identical twins have the exact same pair of chromosomes. This will be true of the other 22 pairs of chromosomes as well. Now, when you and your sister have children with your partners, it might look like this: I’ve put your partners’ chromosomes in black. Since your partners aren’t related, we don’t need to consider their contribution since we’re focusing on you and your sisters’ DNA to determine how your kids are related. When you and your sister make eggs to pass your DNA on to your children, your chromosomes will recombine in their own, unique ways. As you can see, your child and your sister’s child ended up with similar but not the same chromosomes from each of you. You probably noticed the regions where the two chromosomes line up. For example, each chromosome has a light blue top. Here are all the matches: As you can tell, they share about half their DNA on each chromosome. On average this will be true of each chromosome they got from you and your sister. The 25% number comes from the fact that the chromosomes the children get from their dads won’t line up this way because the dads aren’t related. Half of one chromosome plus none of the other gets us to 25% related.