A statewide Silver Alert has been issued for Angel Marie Combs, a 23-year-old missing from Charlestown, Indiana.

She's described as 4'11" tall, 146 pounds, with brown hair and brown eyes.

She was last seen Tuesday afternoon wearing blue jeans and a long-sleeve shirt.

Police say she is believed to be in extreme danger and may require medical assistance.

If you have any information about Angel Marie Combs, contact the Clark County Sheriff’s Office at 812-246-6996 or 911.