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Matt Stafford's wife is PISSED AGAIN ... claiming the refs "screwed" her husband's Detroit Lions out of another victory Thursday night -- and once again, she's venting on social media.

Kelly Stafford has a history of going public with her disdain for the officiating -- and this time, she was clearly upset with the controversial facemask penalty against the Lions that set up GB's game-winning Hail Mary TD on the last play of the game.

"At least my brother was here to see us get screwed per the usual," Kelly wrote ... adding, "#detroitvseverybody."

Earlier this season, Stafford's wife called the refs "incompetent" after the Lions lost to the Seahawks ... and last year, she criticized NFL officials for babying Aaron Rodgers.