A woman has been killed and nine injured after a car ploughed into a cafe in Sydney's north-west in what emergency services have described as a "horrendous and chaotic" scene.

The Holden Commodore drove into diners at a cafe near the corner of Roma Street and Malton Road in North Epping about 10am on Friday, pinning at least two people against a wall, according to NSW Ambulance.

A 40-year-old woman was killed and nine others injured after a car crashed into a cafe in Sydney's north. Credit:Rhett Wyman

A 40-year-old woman was taken in a critical condition with serious abdominal injuries to Royal North Shore Hospital, where she died, police said.

The woman has been identified as Liz Albornoz, a mother of two young girls, according to Nine News. Paramedics treated nine others, including four who were taken to hospital in a stable condition.