Adoring fans won't be the only people heading down to Copps Coliseum for Oprah Winfrey's Hamilton soirée on Saturday. A group of pro-foreskin activists — yes, you read that correctly — plans to protest outside the event.

The group, which picketed outside the TV talk queen's appearance in Vancouver in January, has taken issue with her endorsement of an anti-aging cream called TNS Recovery Complex.

The preparation, produced by American cosmetics company SkinMedica, contains fibroblasts — cells that have been reproduced from a piece of human foreskin.

"How would Oprah respond if a skin cream for men hit the market that was made using cells from the genitalia of little girls?" Glen Callender, founder of the Canadian Foreskin Awareness Project, told the Toronto Star. "I think she would be absolutely disgusted and appalled, and rightly so. So it's crazy that she's doing the opposite."

The Canadian Foreskin Awareness Project opposes the practice of circumcision, arguing that it is medically unnecessary and limits sexual pleasure.

The group is also organizing protests for Winfrey's tour stops in Ottawa and Montreal.

SkinMedica founder Dr. Richard Fitzpatrick has said the company reproduces cells from foreskin that was obtained over 20 years ago, not from babies who've been recently circumcised.

"Initially, there was a misunderstanding and people thought we were actually grinding up the foreskin," he told the San Diego CityBeat in 2010. "So, there was a lot of snickering and laughing about people putting this foreskin product on their face."