A cyclist has died after she was hit by a truck at a major Melbourne intersection.

Police said the woman was struck at the intersection of Punt and Toorak roads, in the inner-city suburb of South Yarra, about 2:15pm.

She died at the scene.

Police said they were speaking with the driver of the truck, who stopped at the scene.

Punt Rd was closed for a number of hours from Toorak Rd north to the Dobson St, near the Yarra River, causing gridlock on neighbouring streets.

Police said they are speaking with the truck driver, who stopped at the scene. ( ABC News )

The woman died on Tuesday about a kilometre away from the site where Dutch cyclist Gitta Scheenhouwer was killed in a hit-and-run incident in August.

The 27-year-old was cycling along a bike lane on Chapel Street, also in South Yarra, on a Sunday morning when she was hit by an allegedly stolen white Mercedes.

She was pinned against another car and died at the scene.

Gitta Scheenhouwer was also killed while riding her bike in South Yarra this year. ( Supplied: Scheenhouwer family )

More than 180 people — including five cyclists — have died on Victoria's roads this year, the Transport Accident Commission said.

Ten cyclists were killed while riding in the state last year.