Stress (cortisol) increases CNR1 thus increasing CB1 receptors in the hypothalamus, leading to lower activity. R

This lower activity allows TRPV1 receptors to be more sensitive (thus decreasing pain threshold). R

CB1 activity is important as it reduce intestinal 5-HT release and increases GABA. R

Stress also increases FAAH and MAGL, which lowers the amount of anandamide (endocannabinoid). R

2. Toxins And Detox Phases

Other toxins may be sprayed or grown with marijuana.

For example, neem oil is used to preserve marijuana and the ingredient Azadirachtin has shown to be toxic (overdose essentially) causing symptoms similar to CHS. R R

3. Other Genetic Problems

Mutations in 5HT1R, CNR1, TRPV1, or GPR55 may cause problems with regulation of CB receptors and endocannabinoids. R R