With the effort to repeal the 2010 health care law on the brink of failure, conservatives are warning that the Republican base will abandon the party. And some are already turning on GOP senators holding up the process.

Three GOP senators have said they would not support moving forward with an effort to repeal much of President Barack Obama’s signature health care law, which would be enough to block the effort. Conservatives, livid with lawmakers reneging on a seven-year promise to undo the law, say not fulfilling that pledge threatens the GOP majorities in Congress.

“If Republicans cannot repeal Obamacare now, they’re going to have to call hospice because their majority is not long for this world,” Tony Perkins, president of the Family Research Council, said on a Wednesday conference call with reporters.

Perkins and leaders of other conservative groups said Republicans will not be motivated to support GOP candidates in future election cycles. They also said the conservative base, unified by the desire to repeal the 2010 law, could back primary challengers against Republicans who vote against moving forward with the bill.

GOP infighting

Some outside groups are already pressuring those GOP senators likely to vote against moving on to the repeal measure. That vote is expected to occur early next week.