LDN treatment works with receptors in the brain and spinal cord. In particular, glial cells are immune cells which encompass nerve cells and usually remain dormant until triggered.5 As signals related to pain become chronic, glial cells are activated and begin to release inflammatory chemicals. For this reason, the inflammatory chemicals disrupt the nerve cells around them and trigger them to become hypersensitized to pain.2-4

In family practice, medications such as Pregabalin (Lyrica) and Gabapentin (Neurontin) are prescribed in order to quiet the pain nerve signals down. Unfortunately, because the nerves are still being bombarded with inflammatory markers being released by the glial cells, these medications are only partly effective.

In reality, the best way to reduce pain is to get the glial cells to become dormant again; and this is where LDN therapy comes into play. LDN works on glial cell receptors triggers them to become dormant and subsequently stop releasing inflammatory chemicals. As a result, the nerve cells to slow down with pain signalling.