Two people have died after a small plane crashed on a mountainside near Mayo Lake, in Yukon, on Tuesday, according the airline.

The plane, a Cessna 208 Caravan operated by Alkan Air, was reported missing just after 12 p.m. local time on Tuesday after leaving Rackla, en route to Mayo, a community of roughly 200 people about 320 kilometres north of Whitehorse.

Rackla is an exploratory camp for possible gold mining. The camp's airstrip is about 150 kilometres northeast of Mayo.

The pilot and one passenger were on board, according to a statement from the airline. Their identities have not been released.

A fly-over located the plane at about 1:30 p.m., according to the statement. The airline is currently working with emergency response teams and local authorities to access the site.

"At this time we can confirm that there are no survivors on-board," the airline said.

The plane was en route from Rackla, a mining exploration camp, to the community of Mayo — a distance of about 150 kilometres — when it went down. (CBC)

"Our hearts go out to everyone that is involved, this is truly a heartbreaking time at Alkan Air."

The Transportation Safety Board says it will arrive in Mayo to begin its investigation into the incident on Thursday, according to spokesperson Alex Fournier.

Fournier added that RCMP will assist TSB investigators on reaching the remote site.

Alkan Air is headquartered in Whitehorse. Operating since 1977, its 23-aircraft fleet primarily provides charter and medevac services in Yukon, British Columbia and Alaska, though it operated a scheduled service between Whitehorse and Watson Lake from 2016 to 2018.