Ramirez is missing Friday's contest against the Tigers because he is sick and not with the team at Comerica Park, Brian MacPherson of the Providence Journal reports.

MacPherson clarified earlier tweets about Ramirez, who's being replaced Friday by Brock Holt at designated hitter. With Mookie Betts already sick Boston probably doesn't want Ramirez to expose the flu to anyone else in the clubhouse, so he may not rejoin the team for the next few days. His status will be one of the most strongly monitored as fantasy players set weekly lineups next Sunday and Monday.