“Hedwig and the Angry Inch” always uses topical and local references written just for the cities where it plays. So it’s natural that when the musical’s national tour finishes in Washington next month, Hedwig, played by Euan Morton, will save her wrath for the most topical local of them all: President Trump.

John Cameron Mitchell, who created the show with Stephen Trask, explains that Hedwig, an East German transgender glam-rocker who escapes Communism, “will be identifying with another Eastern European gold digger.”

The line? “I sit in my mobile home watching the Berlin Wall come down, recalling with envy Mother’s escape to sunny Yugoslavia with the help of her close friend Melania. We are all Melania now.”

Other typical targets include local celebrities, conservative politicians, hipster enclaves and the “rough street in town,” explained Mr. Morton, who along with Mr. Mitchell, wrote most of the material for this part of the tour. They get advice from Michael Rudd, the assistant company manager, who from city to city collects suggestions from residents on references that might click.