Brain Scientists Trace Rat Ticklishness To Play Behavior

Enlarge this image toggle caption Shimpei Ishiyama and Michael Brecht/Science Shimpei Ishiyama and Michael Brecht/Science

Scientists have pinpointed the ticklish bit of a rat's brain.

The results, published in the journal Science, are another step toward understanding the origins of ticklishness, and its purpose in social animals.

Although virtually every human being on the planet has been tickled, scientists really don't understand why people are ticklish. The idea that a certain kind of touching could easily lead to laughter is confusing to a neuroscientist, says Shimpei Ishiyama, a postdoctoral research fellow at the Bernstein Center for Computational Neuroscience in Berlin, Germany.

"Just a physical touch inducing such an emotional output — this is very mysterious," Ishiyama says. "This is weird."

To try and get a handle on how tickling works, Ishiyama studied rats, who seem to enjoy being tickled, according to previous research. He inserted electrodes into the rats' brains, in a region called their somatosensory cortex.

Giggling Rats When rats enjoy tickling they emit high-pitched "laughter" that can't normally be heard by humans, the scientists found. In this video, the researchers transposed the audio of the squeaks to a lower frequency you can hear.

That's a part of the brain that processes touch, and when Ishiyama tickled the rats, it caused neurons in that region to fire. The rats also seemed to giggle hysterically, emitting rapid-fire, ultrasonic squeaks. Earlier research has shown rats naturally emit those squeaks during frisky social interaction, such as when they are playing with other rats.

Next, Ishiyama pretend-tickled the rats by moving his hand around the cage in a playful manner. Rather than withdraw, the rats sought more contact. Again, he saw the neurons in the somatosensory cortex firing, even though the rats weren't being touched. This suggested to him that anticipation of tickling could trigger the region of the brain that responds to touch — even without the physical stimulus.

Finally, Ishiyama stimulated the somatosensory cortex directly, by sending an electrical signal directly into the brain. The rats squeaked the same way, suggesting that this region really is the tickling epicenter of a rat's brain.

Jumping For Joy The researchers noticed that, when tickled and in the mood for play, the rats hopped. Ishiyama called these voluntary hops "joy jumps."

Ishiyama says that was a clear "eureka moment." The role of the somatosensory region of the brain appears to be more complex than originally thought. Rather than being a simple signal-processing center, he says, the region seems to have some connection to emotion.

The result is another important step in understanding ticklishness, says Jaak Panksepp, a psychobiologist and researcher at Washington State University, who studies animal tickles.

Panksepp says that the evolutionary origins of ticklishness remain unclear, but he thinks that it may have evolved to encourage play, which in turn teaches social animals how to interact.

"Children love to be tickled," he says. "That's part of growing up and becoming a full human being."