A maniac is on the loose after he gunned down two people with an AR-15 in the middle of Houston rush-hour traffic — and then bolted in his car, sparking a manhunt, according to a new report.

The chaos unfolded just before 6 p.m. Thursday on eastbound Interstate 10, when the shooter and another person in his sedan struck another vehicle, causing it to spin out, local outlet ABC 13 reported.

Both suspects got out of the car — and one of them opened fire, according to the report.

“A Hispanic male, tan shirt, holding a really big gun, shooting at another car,” a police dispatcher said.

Assistant Chief Bobby Dobbins of the Houston Police Department told the station a witness caught a glimpse of the weapon.

“He’s familiar with guns and he believes it was an AR-15,” the police official said.

“Unreal scene just witnessed on I-10 in Houston, eastbound lanes at Holland, just outside the east loop,” KHOU reporter Daniel Gotera tweeted at the time. “A guy gets out of his car with gun just shooting in the middle of freeway. Unbelievable.”

As the victims’ car rolled toward the gunman, he popped off multiple shots, killing both men in the vehicle, before taking off, authorities told ABC 13.

One driver told authorities he fired at the shooter with a pistol that he carries for personal protection. It was unclear if the gunman was hit, according to the report.

“This is a scary event to happen at 6 o’clock at night on a busy freeway,” Dobbins said.

Police weren’t ruling out any possible motives.

“Road rage? An accident? Narcotics? We don’t know yet,” the assistant chief said.

The victims, who have yet to be identified, had a large garbage bag filled with marijuana in their car, police sources told the outlet.

Later Thursday, authorities were checking in with local business, including hotels — urging them to be extra cautious about who walks in.

Authorities said Friday that the shooter is a Hispanic man in his 20s, about 5-foot-7. He was last seen wearing a red shirt and took off in a newer model, dark-colored, four-door sedan.

Houston Police also announced that they would offer up to $5,000 for any information leading to arrests of the suspects.

Any leads can be called in to the department’s homicide division at 713-308-3600. Anonymous tips can also be called into Crime Stoppers of Houston at 713-222-TIPS.