Washington (CNN) Florida Gov. Ron DeSantis has issued an executive order mandating a 14-day self-quarantine or isolation period for travelers coming to Florida from airports in New York, New Jersey and Connecticut amid the novel coronavirus pandemic.

The order marks the first large-scale attempt by a state to impose a self-quarantine period for domestic travelers and underscores the expansive measures elected officials are attempting -- and willing -- to enact as the outbreak spreads. The move raises questions about how the state of Florida could enforce such an order and whether it will be a constitutional issue because the federal government regulates interstate business, such as air travel.

"I hereby direct all persons whose point of departure originates from outside the State of Florida in an area with substantial community spread, to include the New York Tri-State Area (Connecticut, New Jersey and New York), and entering the State of Florida through airports to isolate or quarantine for a period of 14 days from the time of entry into the State of Florida or the duration of the person's presence in the State of Florida, whichever is shorter," the executive order says.

Explaining the move at a press conference Monday, DeSantis, a Republican, said, "Today there's over 190 direct flights from the New York City area to the state of Florida, and I would reckon, given the outbreak there, that every single flight has somebody on it who's positive for Covid-19," DeSantis, a Republican, said at a press conference Monday explaining the order.

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