NSW Police have arrested more than 80 people in a Christmas cocaine crackdown operation in Sydney's CBD and the eastern suburbs.

Officers seized more than 350 grams of cocaine, five grams of MDMA, five grams of cannabis and almost $70,000 in raids carried out on city streets over six nights in November and December.

NSW Police said "several individuals from well-regarded professions in the community" had been caught up in the swoops.

Police cuff and lead away a suspect during one of many raids carried out in the city before Christmas. (Supplied)

"Officers were astounded by how brazen some of these alleged drug transactions have become, often taking place in highly-visible and crowded locations in Sydney's CBD and surrounding suburbs," Redfern Region Enforcement Squad Commander, Detective Chief Inspector Stuart Bell, said.

"Unfortunately, some of these people will now spend Christmas behind bars or are likely to start 2020 with a criminal record."

A 51-year-old taxi driver was arrested in the harbourside tourist precinct Barangaroo, with police allegedly finding more than 13 grams of cocaine, $3400 cash and two mobile phones in a hidden compartment.

Other notable arrests included the driver of a Toyota Hilux stopped near Martin Place in the CBD, allegedly carrying 13 grams of cocaine, and another driver who allegedly stuffed 13 grams of cocaine inside a Red Bull energy drink can.

Cocaine allegedly found inside a Red Bull can. Officers stopped and searched a vehicle on Eloura Road, Cronulla, allegedly finding $2970 cash, four mobile phones, and more than 13 grams of cocaine concealed in the energy drink can. (Supplied)

The secret compartment found by NSW Police after they stopped a taxi in Barangaroo. (Supplied)

One driver was charged after allegedly driving his vehicle towards a plain clothes police officer while trying to flee a traffic stop in Hunter Street, in Sydney's CBD.

This latest phase of Strike Force Northrop has seen police cuff more than 80 people.

In May 2019, strike force investigators arrested and charged 55 people allegedly linked to "Dial-a-Dealer" services running in the CBD and eastern suburbs.

Police have described the "Dial-a-Dealer" operation as a sophisticated organised criminal network.

"This operation once again shows that cocaine supply and possession is not limited to one specific group of people, with several individuals from well-regarded professions in the community among those now before the courts," Mr Bell said.

"We want everyone to be able to enjoy the festive and holiday season sensibly and safely, but sadly there are some in the community that continue to ignore the warnings."

NSW Police arrest a man in the city's CBD. (Supplied)

Since its inception in 2017, Strike Force Northrop investigators have charged 251 people with drug-related offences, including 160 for supply.

Over the past two years, investigators have seized more than 3.6kg of cocaine, 470 grams of MDMA, 167grams of cannabis and more than $980,000 cash.