A Melbourne mother died in the driveway of her Seaford home after being stabbed in front of three young children.

The woman's 44-year-old ex-partner has been charged with one count of murder after police were called to a home on Whitby Way about 4.40pm on Tuesday.

A police spokeswoman said the woman, aged in her 40s, was found with stab wounds and died at the scene.

The woman and her alleged killer cannot be identified for legal reasons.