A MELBOURNE woman who already has 12 children at home has given birth to quintuplets.

The 48-year-old woman, who conceived naturally, gave birth to two boys and three girls yesterday at Monash Medical Centre, but one of the girls has died, Seven Network reported.

A spokesman for Monash Medical Centre confirmed that four babies were delivered healthy.

''One unfortunately did not make it,'' he said. ''Mum is doing well.''

The babies were delivered by caesarean section by a team of 30 specialists.