Gamma Linolenic Acid (GLA) has been shown to restore nerve conduction velocity in animals that have had a 25% decrease in nerve conduction velocity due to diabetes [iii]. Additionally it has been used to treat rheumatoid arthritis, acute respiratory distress syndrome, stress, and premenstrual syndrome. GLA is derived from borage seed oil, which has been used to reduce pain and swelling, prevent heart disease, and even to protect against stroke.

Alpha Lipoic Acid (ALA) has been shown in placebo controlled randomized studies to improve diabetic neuropathy symptoms. In the SYDNEY 2 trial, there was demonstrated to be a 52% decrease in the amount of pain experienced (including stabbing pain, burning pain, paresthesia, and asleep numbness of the feet) after five weeks of 600 mg ALA [i]. The results of this four year study show clinically meaningful improvement and delay in the progression of diabetic neuropathy. ALA is also attributed with improving blood flow via vasodilation of the brachial artery [ii].

Benfotiamine (Vitamin B-1) – A statistically significant (p = 0.0287) improvement in the neuropathy score was observed in a group given benfotiamine [iv]. It is often prescribed in Germany as a treatment for sciatica and other neuropathic pain complaints.

Vitamin D enhances the absorption of important minerals and specifically addresses the vitamin deficiency common to type 1 and 2 diabetes. It has been shown to reduce the severity of diabetic neuropathy. [vi]

Vitamin B-12 is important to the normal functioning of the nervous system, DNA synthesis and overall metabolism, and has been shown to relieve the symptoms of paraesthesia. Vitamin B-12 restores blood flow which produces myelin synthesis, a fatty substance that protects the nerve fibers. [vii]