SANTA CLARA – The 49ers could be down another edge rusher on Sunday night, as it appears defensive end Dee Ford is unlikely to play against the Green Bay Packers.

Ford sustained a right hamstring strain on Sunday against the Arizona Cardinals while throwing Kyler Murray for a 5-yard sack in the second quarter of the 49ers’ 36-26 victory at Levi’s Stadium. Ford ranks third on the team with 6.5 sacks.

“Any time you have a hamstring strain, there is concern it could be a couple of weeks,” coach Kyle Shanahan said on Monday.

The 49ers hope to get tight end George Kittle back on the field after missing two games with undisclosed knee and ankle issues. Shanahan declined to identify the nature of Kittle’s injuries.

“I know it was enough to keep most people out for some time, which is has for George,” Shanahan said. “He’s missed two games now, and I know it will go down to the wire again this week. But hoping this week will be different.”

The 49ers (9-1) have a huge NFC matchup on Sunday night against the Packers (8-2). The 49ers lead the race in the NFC West, as well as home-field advantage in the playoffs. The Seattle Seahawks (8-2) are one game behind the 49ers for the division lead. The New Orleans Saints (8-2) are also in the mix for home-field advantage.

Shanahan said running back Matt Breida (ankle) and kicker Robbie Gould (right quadriceps) are uncertain for participation in practice on Wednesday due to their injuries. Gould has missed two games, while Breida sat out Sunday’s game.

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Wide receivers Emmanuel Sanders (ribs) and Deebo Samuel (shoulder) played Sunday but are uncertain for practice participation on Wednesday. Their availability will be determined later in the week.

Nose tackle D.J. Jones (groin) and left tackle Joe Staley (finger) are not expected to be available this week due to their injuries.