Archaeologists recently found a 2,700-year-old pot stash, so we know humans have been smoking weed for thousands of years. But it was only about 20 years ago that neuroscientists began to understand how it affects our brains.


Scientists have known for a while that the active ingredient in cannabis was a chemical called delta-9-tetrahydrocannabinol, or THC for short. Ingesting or smoking THC has a wide range of effects, from the psychoactive "getting high" to the physiological relief of pain and swelling. It also acts as both a stimulant and depressant. How could one substance do all that?


Meet the cannabinoid receptor



In the 1980s and 90s, researchers identified cannabinoid receptors, long, ropy proteins that weave themselves into the surfaces of our cells and process THC. They also process other chemicals, many of them naturally occurring in our bodies. Once we'd discovered these receptors, we knew exactly where THC was being processed in our bodies and brains, as well as what physical systems it was affecting. Scattered throughout the body, cannabinoid receptors come in two varieties, called CB1 and CB2 - most of your CB1 receptors are in your brain, and are responsible for that "high" feeling when you smoke pot. CB2 receptors, often associated with the immune system, are found all over the body. THC interacts with both, which is why the drug gives you the giggles and also (when interacting with the immune system) reduces swelling and pain.

Cannabinoid receptors evolved in sea squirts about 500 million years ago; humans and many other creatures inherited ours from a distant ancestor we share with these simple sea creatures. THC binds to receptors in animals as well as humans, with similar effects.

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Tasty, tasty, tasty



Cannabis notoriously makes people hungry - even cancer patients who had lost all desire to eat. One study showed that cancer patients who thought food smelled and tasted awful suddenly regained an ability to appreciate food odors after ingesting a THC compound. There are CB1 receptors in your hypothalamus, a part of your brain known to regulate appetite, and your body's own cannabinoids usually send the "I'm hungry" message to them. But when you ingest THC, you artificially boost the amount of cannabinoids sending that message to your hypothalamus, which is why you get the munchies.

Understanding this process has actually led to a new body of research into safe diet drugs that would block those cannabinoid receptors. That way, your hypothalamus wouldn't receive signals from your body telling it to eat, and would reduce hunger cravings in dieters.


What you're forgetting



What's happening in your brain when smoking pot makes you forget what you're saying in the middle of saying it? According to the book Marijuana and Medicine (National Academies Press):

One of the primary effects of marijuana in humans is disruption of short-term memory. That is consistent with the abundance of CB1 receptors in the hippocampus, the brain region most closely associated with memory. The effects of THC resemble a temporary hippocampal lesion.


That's right - smoking a joint creates the effect of temporary brain damage.

What happens is that THC shuts down a lot of the normal neuroprocessing that goes on in your hippocampus, slowing down the memory process. So memories while stoned are often jumpy, as if parts are missing. That's because parts literally are missing: Basically you are saving a lot less information to your memory. It's not that you've quickly forgotten what's happened. You never remembered it at all.


A bit of the old timey wimey



Cannabis also distorts your sense of time. THC affects your brain's dopamine system, creating a stimulant effect. People who are stoned often report feeling excited, anxious, or energetic as a result. Like other stimulants, this affects people's sense of time. Things seem to pass quickly because the brain's clock is sped up. At the same time, as we discussed earlier (if you can remember), the drug slows down your ability to remember things. That's because it interferes with the brain's acetylcholine system, which is part of what helps you store those memories in your hippocampus. You can see that system's pathway through the brain in red in the illustration at left.


In an article io9 published last year about the neuroscience of time, we noted:

The interesting thing about smoking pot is that marijuana is one of those rare drugs that seems to interact with both the dopamine and the acetylcholine system, speeding up the former and slowing down the latter. That's why when you get stoned, your heart races but your memory sucks.


It's almost as if time is speeding up and slowing down at the same time.

Addiction and medicine



Some experts call cannabis a public health menace that's addictive and destroys lives by robbing people of ambition. Other experts call it a cure for everything from insomnia to glaucoma, and advocate its use as a medicine. The former want it to be illegal; the latter want it prescribed by doctors. Still other groups think it should be treated like other intoxicants such as alcohol and coffee - bad if you become dependent on it, but useful and just plain fun in other situations.


What's the truth? Scientists have proven that cannabis does have medical usefulness, and the more we learn the more intriguing these discoveries become. Since the early 1980s, medical researchers have published about how cannabis relieves pressure in the eye, thus easing the symptoms of glaucoma, a disease that causes blindness. THC is also "neuroprotective," meaning in essence that it prevents brain damage. Some studies have suggested that cannabis could mitigate the effects of Alzheimer's for this reason.

At the same time, we know that THC interferes with memory, and it's still uncertain what kinds of long-term effects the drug could have on memory functioning. No one has been able to prove definitively that it does or does not erode memory strength over time. Obviously, smoking it could cause lung damage. And, like the legal intoxicant alcohol, cannabis can become addictive.


Should cannabis be illegal, while alcohol flows? Unfortunately that's not the kind of question that science can answer. Let's leave the moral questions to courts, policymakers and shamans. I'll be off to the side, smoking a joint, thinking about my acetylcholine system and the many uses of the hippocampus.