Novak Djokovic’s second round exit triggered by World Number 117 Denis Istomin has to be one of the biggest upsets in the Serb’s career.

The six time winner looked visibly shaken and never looked comfortable and ultimately lost 7-6(10-8), 5-7,2-6,7-6(7-5),6-4 in a match that lasted four hours and 48 minutes.

Djokovic’s early exit leaves World Number 1 Andy Murray as one of the favorites to clinch the first slam of 2017.

Let us look at some of Djokovic’s earliest grand slam exits since breaking in the Top 3.

Wimbledon 2016- 3rd Round

Even when the best player in the world was down two sets to none – after a tight opening set, 28th-seeded American Sam Querrey stormed through five straight games to take the second – it never looked like their third round encounter at Wimbledon was out of the 12-time Grand Slam champion’s grasp.

But it was, as Querrey maintained his focus after dropping the third set and came back from a break down in the fourth to close out the biggest win of his career and arguably the biggest upset in tennis since Robin Soderling beat Rafael Nadal in the fourth round of the 2009 French Open. A Djokovic forehand that landed well wide ended his pursuit of the calendar-year Grand Slam and clinched the match for Querrey, 7-6 (6), 6-1, 3-6, 7-6 (5).

While this match will certainly go down as one of the greatest upsets ever, the loss was just that for Djokovic – a loss.

“It’s not the first time that I’m losing in a Grand Slam match, or any match for that matter,” Djokovic said. “I managed to win four Grand Slams in a row – two different seasons, though. I want to try to focus on that rather than on failure.”