A Pennsylvania tourist collapsed and died in the same Dominican Republic resort where a couple from Maryland was found dead five days later — and from the very same condition, according to her family.

Psychotherapist Miranda Schaup-Werner, 41, from Allentown, died in front of her husband in their room in the Bahía Príncipe resort in La Romana on May 25 after having a drink from the minibar, a family spokesman said.

Nathaniel Holmes, 63, and Cynthia Ann Day, 49, checked into the all-inclusive resort the same day — and just five days later were also found dead in their room.

All three died of respiratory failure, according to Fox, which a family spokesman for Schaup-Werner called “beyond coincidence.”

Schaup-Werner’s family is so “alarmed” by the ” disturbing similarity ” between the deaths they have called on the US State Department to investigate.

“It was, at first, a little confusing that there was such a strong parallel … it immediately caused serious concern for us,” said Jay McDonald, acting as the family spokesman for Schaup-Werner’s grieving husband, Daniel Werner.

“They died five days after, and the cause was determined to be the same, this just puts this whole thing through the stratosphere — something is going on, and we want to know what it is.”

Schaup-Werner and her husband had been on the island celebrating her ninth anniversary when she suddenly collapsed after having a drink, McDonald told Fox.

“She started shrieking and she dropped to the floor. He attempted to do CPR, he tried to resuscitate her,” McDonald said his brother-in-law told him.

Paramedics arrived and gave an epinephrine injection — usually used to treat severe allergic reactions. “At that point, they just declared her dead,” McDonald said, adding that the authorities “did a very cursory [look] into determining the cause of death.”

“Daniel and all of us are in a state of disbelief, we are shocked. She was perfectly content, everything seemed fine,” McDonald insisted.

The US State Department confirmed the three deaths.

“The U.S. Embassy is actively monitoring the investigations by Dominican authorities into these tragic deaths,” it said in a statement to Fox.

“We stand ready to provide assistance as requested.”

Bahia Principe resorts stressed in a statement that the deaths occurred in different hotels within the resort — Schaup-Werner at the Luxury Bahia Principe Bouganville and Holmes and Day at the Grand Bahia Principe La Romana.

“To date, there are no indications of any correlation between these two unfortunate incidents,” the statement insisted.

“In both circumstances, established security protocols were followed, and we have maintained open communication with the authorities to provide information and clarification for each case.”

It also insisted that “providing a safe and welcoming environment for travelers stands at the heart of our company values.”