There were significant changes at Vice Media on Monday as the company — which was once operated more like a frat party than a business — takes shape under new leadership.

First came the news that HBO was canceling the nightly program “Vice News Tonight” and that the executive who oversaw the show, Josh Tyrangiel, would be leaving the company.

Vice Media quickly followed that report, which appeared in The Hollywood Reporter, with an announcement that Jesse Angelo, the former publisher of The New York Post, would become the company’s president of global news and entertainment.

The changes occurred on the watch of Nancy Dubuc, a former head of the A&E cable network who joined Vice Media as chief executive last year and has been charged with the task of stanching the flow of red ink at the company.