Story highlights The International Cycling Union can review and appeal the case, an official says

The U.S. Anti-Doping Agency said he will be stripped of his titles

Armstrong calls the agency's process "one-sided and unfair"

A former trainer calls the USADA process "unjust"

Famed cyclist Lance Armstrong is facing the loss of seven Tour de France titles and his championship legacy after ending his fight against charges of illegal doping.

Armstrong's move prompted the U.S. Anti-Doping Agency on Friday to slap a lifetime ban on the athlete and strip him of his wins dating to 1998, though there is a question of whether the organization has the authority to take such action.

"If I thought for one moment that by participating in USADA's process I could confront these allegations in a fair setting and -- once and for all -- put these charges to rest, I would jump at the chance," Armstrong said in a statement Thursday

"I refuse to participate in a process that is so one-sided and unfair."

The World Anti-Doping Agency and the International Cycling Union will review the USADA's findings, with one or both agencies then given the option to appeal the case before Armstrong can be banned or stripped of titles.

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Photos: Photos: Lance Armstrong's rise and fall Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – After denying the allegations for years, cyclist Lance Armstrong admitted to using performance-enhancing drugs. As a result, he was stripped of his seven Tour de France titles and an Olympic bronze medal. Click through the gallery for a look at his life and career. Hide Caption 1 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong, 17, competes in the Jeep Triathlon Grand Prix in 1988. He became a professional triathlete at age 16 and joined the U.S. National Cycling Team two years later. Hide Caption 2 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong wins the 18th stage of the Tour de France in 1995. He finished the race for the first time that year, ending in 36th place. Hide Caption 3 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong rides at the Ikon Ride for the Roses to benefit the Lance Armstrong Foundation in May 1998. He established the foundation to benefit cancer research after he was diagnosed with testicular cancer in 1996. After treatment, he was declared cancer-free in February 1997. Hide Caption 4 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong leads his teammates during the final stage of the 1999 Tour de France. Hide Caption 5 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong takes his honor lap on the Champs-Élysées in Paris after winning the Tour de France for the first time in 1999. Hide Caption 6 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – After winning the 2000 Tour de France, Armstrong holds his son Luke on his shoulders. Hide Caption 7 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong rides during the 18th stage of the 2001 Tour de France. He won the tour that year for the third consecutive time. Hide Caption 8 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong celebrates winning the 10th stage of the Tour de France in 2001. Hide Caption 9 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – After winning the 2001 Tour de France, Armstrong presents President George W. Bush with a U.S. Postal Service yellow jersey and a replica of the bike he used to win the race. Hide Caption 10 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong celebrates on the podium after winning the Tour de France by 61 seconds in 2003. Hide Caption 11 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Jay Leno interviews Armstrong on "The Tonight Show" in 2003. Hide Caption 12 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – After his sixth consecutive Tour de France win, Armstrong attends a celebration in his honor in front of the Texas State Capitol in Austin. Hide Caption 13 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong arrives at the 2005 American Music Awards in Los Angeles with then-fiancee Sheryl Crow. The couple never made it down the aisle, splitting up the following year. Hide Caption 14 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong holds up a paper displaying the number seven at the start of the Tour de France in 2005. He went on to win his seventh consecutive Tour de France. Hide Caption 15 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong testifies during a Senate hearing in 2008 on Capitol Hill. The hearing focused on finding a cure for cancer in the 21st century. Hide Caption 16 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – In 2009, Armstrong suffered a broken collarbone after falling during a race in Spain. Hide Caption 17 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Young Armstrong fans write messages on the ground ahead of the 2009 Tour de France. He came in third place that year. Hide Caption 18 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong launches the three-day Livestrong Global Cancer Summit in 2009 in Dublin, Ireland. The event was organized by his foundation. Hide Caption 19 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – In May 2010, Armstrong crashes during the Amgen Tour of California. That same day, he denied allegations of doping made by former teammate Floyd Landis. Hide Caption 20 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong looks back as he rides during the 2010 Tour de France. Hide Caption 21 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong's son Luke; his twin daughters, Isabelle and Grace; and his 1-year-old son, Max, stand outside the Radio Shack team bus on a rest day during the 2010 Tour de France. Hide Caption 22 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong finished 23rd in the 2010 Tour de France. He announced his retirement from the world of professional cycling in February 2011. He said he wanted to devote more time to his family and the fight against cancer. Hide Caption 23 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – The frame of Armstrong's bike is engraved with the names of his four children at the time and the Spanish word for five, "cinco." His fifth child, Olivia, was born in October 2010. Hide Caption 24 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong competes in the 70.3 Ironman Triathlon in Panama City, Florida, in February 2012. He went on to claim two Half Ironman triathlon titles by June of that year. Hide Caption 25 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – Armstrong addresses participants at the Livestrong Challenge Ride on October 21, 2012, days after he stepped down as chairman of his Livestrong cancer charity. Hide Caption 26 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – International Cycling Union President Pat McQuaid announces the decision to strip Armstrong of his seven Tour de France wins and ban him from the tournament for life on October 22, 2012. "Lance Armstrong has no place in cycling," he said. Hide Caption 27 of 28 Photos: Photos: Lance Armstrong's rise and fall Lance Armstrong's rise and fall – In January 2013, Armstrong speaks with Oprah Winfrey about the controversy surrounding his cycling career. He admitted, unequivocally and for the first time, that he used performance-enhancing drugs while competing. Hide Caption 28 of 28

Armstrong has vehemently denied U.S. Anti-Doping Agency allegations that he took steroids throughout his career. The agency said it has testimony from former teammates to support the charges, though it has declined to reveal who provided the evidence.

The International Cycling Union, which Armstrong has said should be the arbiter of his case, has previously opposed the USADA actions by claiming it has jurisdiction. That position has been recently backed by USA Cycling, the official cycling organization recognized by the U.S. Olympic Committee.

But the U.S. agency said the anti-doping regulations that Armstrong is being sanctioned for are defined as violations by the cycling union and other agencies, all of which have adopted the World Anti-Doping Code and the WADA's prohibited list.

The International Cycling Union said Friday it will not comment on the case until the USADA issues "a reasoned decision" explaining its stance.

The cycling union has 21 days to file an appeal following a review of the USADA case, and then the World Anti-Doping Agency can file its own appeal, said Terence O'Rorke, a spokesman for the WADA.

The World Anti-Doping Agency's president, John Fahey, said on Australian radio that the allegations against Armstrong have credibility. He said he is disappointed the case would not be tested because of Armstrong's decision not to challenge the charges.

The U.S. agency has charged Armstrong with using, possessing, trafficking and giving to others performance-enhancing drugs, as well as covering up doping violations.

"Nobody wins when an athlete decides to cheat with dangerous performance-enhancing drugs, but clean athletes at every level expect those of us here on their behalf to pursue the truth to ensure the win-at-all-cost culture does not permanently overtake fair, honest competition" said U.S. Anti-Doping Agency CEO Travis Tygart.

"Any time we have overwhelming proof of doping, our mandate is to initiate the case through the process and see it to conclusion, as was done in this case."

Armstrong has been an icon for his feats and celebrity, bringing more status to a sport wildly popular in some nations but lacking big-name recognition, big money and mass appeal in the United States.

He fought back from testicular cancer to win the Tour from 1999 to 2005. He raised millions via his Lance Armstrong Foundation to help cancer victims and survivors, an effort illustrated by trendy yellow "LiveSTRONG" wristbands that helped bring in the money.

The cyclist's one-time high-profile relationship with singer Sheryl Crow also kept him in the public eye.

But Armstrong has been dogged by doping allegations in recent years, with compatriot Floyd Landis -- who was stripped of his 2006 Tour de France title after failing a drug test -- making a series of claims last year.

Armstrong sued the U.S. Anti-Doping Agency to stop its investigation of him, arguing it did not have the right to prosecute him.

But a federal judge Monday dismissed Armstrong's lawsuit after ruling the court did not have jurisdiction.

After that ruling, Armstrong said "enough is enough" in the face of his battle with the USADA and Tygart, whose investigation he describes as a farce. The U.S. agency is the official anti-doping agency for Olympic, Pan American and Paralympic sports in the United States.

"I have been dealing with claims that I cheated and had an unfair advantage in winning my seven Tours since 1999," Armstrong said. Over the past three years, I have been subjected to a two-year federal criminal investigation followed by Travis Tygart's unconstitutional witch hunt. The toll this has taken on my family, and my work for our foundation and on me leads me to where I am today -- finished with this nonsense."

Armstrong said he plans to help people "affected by cancer" and is "looking forward to an end to this pointless distraction."

"Today I turn the page. I will no longer address this issue, regardless of the circumstances," he said "I have a responsibility to all those who have stepped forward to devote their time and energy to the cancer cause. I will not stop fighting for that mission. Going forward, I am going to devote myself to raising my five beautiful (and energetic) kids, fighting cancer, and attempting to be the fittest 40-year old on the planet."

Armstrong came out fighting in May 2011, in the face of fresh allegations made on CBS News' "60 Minutes" show by another American, Tyler Hamilton.

In the CBS interview, Hamilton -- who retired in 2009 after twice testing positive himself and who, earlier this month, was stripped of his 2004 gold medal by the International Olympic Committee because of doping -- said he first saw Armstrong use EPO in 1999.

EPO, or erythropoietin, boosts the number of red blood cells, which carry oxygen to the muscles.

Armstrong has said in court documents that he has never had "a single positive test" in the 500 to 600 drug tests he's taken in his more than two decades in cycling.

"From the beginning, however, this investigation has not been about learning the truth or cleaning up cycling, but about punishing me at all costs. I am a retired cyclist, yet USADA has lodged charges over 17 years old despite its own 8-year limitation," Armstrong said in Thursday's statement.

"The only physical evidence here is the hundreds of controls I have passed with flying colors. I made myself available around the clock and around the world. In competition. Out of competition. Blood. Urine. Whatever they asked for I provided. What is the point of all this testing if, in the end, USADA will not stand by it?"

In February, Justice Department prosecutors said they closed a criminal investigation after reviewing allegations against Armstrong. They had called witnesses to a federal grand jury in Los Angeles, but apparently determined they lacked evidence to bring a charge that Armstrong used performance-enhancing drugs.

In a June letter to Armstrong, a copy of which was obtained by CNN, the USADA said it collected blood samples from him in 2009 and 2010 that were "fully consistent with blood manipulation including EPO use and/or blood transfusions."

After Armstrong filed his suit to stop the agency's investigation, the USADA said Friday that all of the evidence "would have been presented in an open legal proceeding for him to challenge. He chose not to do this knowing these sanctions would immediately be put into place."

U.S. District Judge Sam Sparks, in ruling Monday that the court did not have jurisdiction, acknowledged that "the appearance of a conflict on the part of both organizations creates doubt the charges against Armstrong would receive fair consideration in either forum." But that doesn't mean federal courts should intervene, the judge said, adding that "these matters should be resolved internally, by the parties most affected."

"If these bodies wish to damage the image of their sport through bitter infighting, they will have to do so without the involvement of the United States courts," Sparks said.

Armstrong said he had hoped that a federal court would stop what he calls the agency's "charade."

"Although the court was sympathetic to my concerns and recognized the many improprieties and deficiencies in USADA's motives, its conduct, and its process, the court ultimately decided that it could not intervene."

Nike and Honey Stinger, Armstrong sponsors, issued statements of support. So did Johan Bruyneel, his former team manager, who said he's "disappointed" that the case reached a point where Armstrong is "no longer willing to participate in USADA's campaign against him."

"Lance has never withdrawn from a fair fight in his life, so his decision today underlines what an unjust process this has been," he said.

John Eustice, a two-time U.S. professional cycling champion, said the group is wrong to assert that it would strip Armstrong of honors such as the Tour de France titles. The tour owner would decide that, he said.

"It's a private enterprise and a private race," he said.

He said people who go into arbitration "have no chance to win."

Armstrong's move isn't an admission of guilt. It's a reaction to an agency's "unmitigated power with complete overreach" that is cowing other sports agencies.

"They feel that they have this world authority to do whatever they want," he said. "He's Moby Dick. They finally got Moby Dick."