Pyroclastic density currents are highly dangerous ground-hugging currents from volcanoes that cause >50% of volcanic fatalities globally. These hot mixtures of volcanic particles and gas exhibit remarkable fluidity, which allows them to transport thousands to millions of tonnes of volcanic material across the Earth’s surface over tens to hundreds of kilometres, bypassing tortuous flow paths and ignoring rough substrates and flat and upsloping terrain. Their fluidity is attributed to an internal process that counters granular friction. However, it is difficult to measure inside pyroclastic density currents to quantify such a friction-defying mechanism. Here we show, through large-scale experiments and numerical multiphase modelling, that pyroclastic density currents generate their own air lubrication. This forms a near-frictionless basal region. Air lubrication develops under high basal shear when air is locally forced downwards by reversed pressure gradients and displaces particles upward. We show that air lubrication is enhanced through a positive feedback mechanism, explaining how pyroclastic density currents are able to propagate over slopes much shallower than the angle of repose of any natural granular material. This discovery necessitates a re-evaluation of hazard models that aim to predict the velocity, runout and spreading of pyroclastic density currents.