Coronavirus infections set a grim high water mark of more than 500,000 infections and over 22,000 deaths, a stark reminder of how the inability to contain surging caseloads in Europe and the United States has brought the global economy to a standstill.

On Thursday, America’s death toll topped 1,000 on over 80,000 diagnoses, according to real time data from Johns Hopkins University, and officially became the epicenter of the global outbreak. Led by soaring infection rates in New York topping 37,000, the U.S. has now overtaken Italy, which also has over 80,000 infections but a far higher death rate of about 10%.

Ironically, China — where the outbreak began — has not reported any new cases, even with the Western world beset by mounting casualties. At last count, the world’s second-largest economy had over 81,000 cases.

At its core a public health crisis, the COVID-19 pandemic has become a force multiplier behind a recession that’s likely to be deep and wrenching, and tumult in global markets that are straining credit markets.

A stark reminder of the growing economic toll was seen on Thursday, when U.S. initial jobless claims skyrocketed to a record of about 3.3 million — far worse than anything seen during the Great Recession.

Governments and central banks around the world have moved to pump their economies full of stimulus, but a growing number of experts fear those efforts will be insufficient to offset the effects of multiple lockdowns that have brought public life to a grinding halt.

A $2 trillion relief package that cleared the Senate late Wednesday will backstop consumers and businesses — and helped send markets on a big rally on Thursday. However, the stimulus is unlikely to inoculate the world’s largest economy from a looming downturn that could see annualized growth plummet by double-digits in the coming months.

Anthony Fauci, the director of the National Institute of Allergy and Infections Diseases, told reporters on Wednesday that the coronavirus could “possibly become a seasonal cyclic thing.”

With African and Southern Hemisphere countries also starting to bubble up, Fauci added that “it will be inevitable that we need to be prepared that we’ll get a cycle a second time.”

View photos The COVID-19 crisis continues its global march. More

New York City is now a battleground in wide-ranging effort to keep citizens indoors amid an explosion of new COVID-19 cases that are swamping the area’s hospitals, a microcosm of what’s already happening in other parts of the country.

On Thursday, NY Governor Andrew Cuomo warned the state’s health facilities were already at critical levels, which officials were moving to scale up to 140,000, from its current 53,000.

Tamara Moise, an emergency physician based in NYC, told Yahoo Finance in an interview that hospitals and urgent care facilities are running out of basic protective supplies.

“We’re having a shortage, we’re having to ration, things are very tough right now and the emergency rooms are really getting it tough,” Moise said. “At this point I feel like we’re not at our peak yet.”

‘Significant pushback’

View photos The U.S. is closing in on Italy with COVID-19 infections, but its death toll is lower. More