Two paramedics and a young man have been taken to hospital after a car smashed into an ambulance as it drove to an emergency in Melbourne's outer south-east.

Two paramedics were in the ambulance, which had its lights and sirens on, as it drove south on the Nepean Highway at Frankston South at 10.50pm on Wednesday, when a car driving in the opposite direction mounted a median strip and collided with the ambulance, a police spokeswoman said.

A car lies is torn in half on the Nepean Highway at Frankston South. Credit:Gary Sissons

The ambulance was extensively damaged but the paramedics had minor injuries. The force of the collision split the car in two.

A spokesman for Ambulance Victoria said the paramedics got out and helped the 21-year-old Seaford man driving the other car.