A police officer has been killed while on an annual motorcycle ride, which set off from Melbourne on Friday to honour officers who have died in the line of duty.

The Age understands a senior sergeant from Melbourne's bayside area was killed after a car travelling west along the Princes Highway at Mount Raymond Regional Park near Orbost veered onto the opposite side of the road about 2.20pm.

He was on the annual Wall to Wall ride with his son, who is also a police officer.

It's believed the veteran police officer was riding on his motorcycle alongside his son when they saw the car driving erratically on the wrong side of the road.

Further details of the crash are yet to be confirmed, but the senior sergeant died at the scene.

It is understood his wife, who is also serving police officer, was also taking part in the ride.

In a brief statement on Facebook, Wall to Wall organisers confirmed the officer's death.

"Tragic news..... the loss of one of our own," it read.

"There is no further information to share at this stage, but proper acknowledgement will be made tomorrow as we reflect and remember a mate. Our sincere condolences to his family and friends... so very sad."

The ride began at the Victoria Police Memorial on St Kilda Road on Friday, about 300 riders were taking part.

Riders were due to stop overnight at Merimbula, southern New South Wales, before continuing on to Canberra on Saturday, but it has since been halted.

The male driver of the car stopped at the scene and is assisting police with their enquiries.

He sustained minor injuries during the collision.