(CNN) Jerry Lewis, the slapstick-loving comedian, innovative filmmaker and generous fundraiser for the Muscular Dystrophy Association, died Sunday after a brief illness, said his publicist, Candi Cazau. He was 91.

Cazau would not elaborate on the illness from which Lewis was suffering. John Fudenberg, coroner for Clark County in Nevada, said Lewis died from heart failure due to peripheral vascular disease.

Lewis first gained fame for his frenzied comedy-and-music act with singer Dean Martin. When that ended in the mid-1950s, Lewis went solo, and by the early '60s, he had become a top draw in movies such as "The Bellboy," "The Nutty Professor" and "The Patsy." Along the way, he pioneered the use of videotape and closed-circuit monitors in moviemaking, a now-standard technique called video assist.

He first helped raise money for muscular dystrophy in a telethon in 1956. He was so successful, and so devoted to the cause, that children affected by the disease became known as "Jerry's kids." The telethon, long known as "The Jerry Lewis MDA Telethon," began airing on Labor Day weekend in 1966, and Lewis served as host until 2011.

Loved and criticized

A promotional photo from "The Jerry Lewis Show," which aired in 1963.

Despite his success, Lewis also was a controversial figure. A number of people suffering with muscular dystrophy claimed Lewis presented victims as childlike and worthy of pity, rather than as equal members of society.

Lewis lost some fans when he criticized women doing comedy -- "I think of (a female comedian) as a producing machine that brings babies in the world," he once said -- and when he lashed out at MDA critics. "You don't want to be pitied because you're a cripple in a wheelchair? Stay in your house!" he said in 2001 on the "CBS Morning Show." He later apologized.

When Lewis was one of America's leading box office attractions, critics mocked him for the broadness of his comedy -- and took more shots at him when he became a renowned figure in France. In 1984, the French awarded Lewis the Legion of Honor, the country's highest tribute.

The White House also paid respects to Lewis, with a statement released late Sunday night.

"Jerry Lewis kept us all laughing for over half a century, and his incredible charity work touched the lives of millions. Jerry lived the American Dream -- he truly loved his country, and his country loved him back. Our thoughts are with his family today as we remember the extraordinary life of one of our greatest entertainers and humanitarians. Thank you, Jerry. You will be missed," the White House statement said.

Lewis was emotional, big-hearted, eccentric -- once successful, he never wore a pair of socks twice -- proud and forever playing to the back row.

He seldom apologized for it.

"Let me tell you that probably 50% of the film community plays a game and does their thing because they're prominent and they're making a lot of money. And what they do is they give up a piece of their soul ... and for them, they're comfortable, and they feel that's fine," he told CNN's Larry King in 2000. "It was never fine for me and I wouldn't go there. I told (legendary Hollywood gossip columnist) Louella Parsons I thought she was a fat pig, because I thought she was. I had an opinion."

The controversy Lewis stirred up over the years did little to dampen his peers' and successors' appreciation of his art. Several celebrities took to social media to share their sadness over his passing.

Comedian Jon Lovitz called Lewis an "amazing talent," while "Star Trek" actor George Takei thanked him for "the laughs and the feels."

Jerry Lewis! Oy! Another comic legend gone. What an amazing talent and philanthropist. A long, well lived life!#RIPJerryLewis — Jon Lovitz (@realjonlovitz) August 20, 2017

We have lost a great comedian and even greater heart. Thank you for the laughs and the feels, Jerry Lewis. https://t.co/vdYCfd7atJ — George Takei (@GeorgeTakei) August 20, 2017

"I sincerely hope his afterlife is a warm, peaceful... ...haven," actor Patton Oswalt wrote.

Jerry Lewis passed today,millions around the world loved him,millions of kids he helped w/his telethons. R.I.P. &condolences 2 his family — Whoopi Goldberg (@WhoopiGoldberg) August 20, 2017

Jerry Lewis has passed on. I sincerely hope his afterlife is a warm, peaceful...



...haven. — Patton Oswalt (@pattonoswalt) August 20, 2017

Wrote Public Enemy frontman Chuck D: "Earth is less funny today."

Jerry Lewis passes today. HipHop had a dance named after him. Last time I performed on @jimmyfallon He was there. Earth is less funny today — Chuck D (@MrChuckD) August 20, 2017

A lonely boy

JUST WATCHED Jillette: Jerry Lewis was the king of comedy Replay More Videos ... MUST WATCH Jillette: Jerry Lewis was the king of comedy 01:13

Joseph Levitch -- he changed the name to Lewis as a teenager -- was born in Newark, New Jersey, on March 16, 1926. Entertainment ran in the family: His father was a vaudeville performer, his mother a piano player. Lewis occasionally performed with his parents, and by the time he was a teenager he had developed his own act. He was a regular in New York's Catskill Mountain resorts, popular summertime retreats for area Jews.

But Lewis was also a lonely boy, essentially raised by his grandmother. Lewis told King that his comedy was rooted in hurt.

"I found (the comic) through pain. And the pain was that I couldn't buy milk like the other kids in school at recess time," he said.

He met Martin at a club in 1945 where the two were performing as soloists. The next year they premiered as a duo in Atlantic City, New Jersey. According to show business lore, their first show flatlined and the team was warned by the club manager to improve or be fired. For the second show, the two went wild with a no-holds-barred mix of comedy and music. It was a hit.

"He provided belly laughs...he just had that spark of genius," says actress Carol Burnett of Jerry Lewis https://t.co/1aK5FT8wJa — CNN Newsroom (@CNNnewsroom) August 20, 2017

Within four years, they were headlining and breaking records at New York's Copacabana club. Lewis later wrote that they set off Beatlemania-type reactions among fans -- especially female fans -- long before the term Beatlemania was coined.

Martin played the romantic, crooning straight man, and Lewis was the anything-for-a-laugh comedian of chaos. (Some observers called them "the organ grinder and the monkey.") The act often featured a stint of Martin chasing Lewis around the stage. They appeared on the very first "Ed Sullivan Show" (then called "Toast of the Town") and shrewdly negotiated control of their various appearances, earning them millions.

But over the course of a decade -- a period that included 17 movies, beginning with 1949's "My Friend Irma" -- the two grew apart. Toward the end, Martin told Lewis he was "nothing to me but a dollar sign." Martin's last performance with Lewis -- also at the Copa -- was on July 25, 1956.

Big life post-Martin

Photos: The life and career of Jerry Lewis Jerry Lewis, the slapstick-loving comedian, innovative filmmaker and generous fundraiser for the Muscular Dystrophy Association, died August 20 after a brief illness, said his publicist, Candi Cazau. He was 91. Hide Caption 1 of 22 Photos: The life and career of Jerry Lewis Lewis monkeys around with Pierre, a 5-year-old chimpanzee, in 1950, during Lewis' early Hollywood days. Hide Caption 2 of 22 Photos: The life and career of Jerry Lewis Lewis joined forces with singer Dean Martin in 1946 and they became a hugely popular duo. Martin and Lewis were comedy partners for 10 years. Hide Caption 3 of 22 Photos: The life and career of Jerry Lewis Martin, center, kisses actress Denise Darcel, as Lewis feigns irritation. The pair were at a golf event in 1953 in Eastchester, New York. Hide Caption 4 of 22 Photos: The life and career of Jerry Lewis Lewis and Martin parted less than amicably in 1956. Both had long and successful careers after their breakup. Hide Caption 5 of 22 Photos: The life and career of Jerry Lewis In 1960, Lewis starred in and directed "The Bellboy," a silent-film-style story of pratfalls and adventures. Hide Caption 6 of 22 Photos: The life and career of Jerry Lewis Lewis' film heyday was the '60s. Here, he stars with Susan Oliver in 1964's "The Disorderly Orderly." Hide Caption 7 of 22 Photos: The life and career of Jerry Lewis Lewis and his wife, Patti, sing in an impromptu New York performance in 1955. They divorced in 1982. Hide Caption 8 of 22 Photos: The life and career of Jerry Lewis Lewis and his family in 1967. He also had a daughter with his second wife. Hide Caption 9 of 22 Photos: The life and career of Jerry Lewis Lewis stars in "The Nutty Professor" in 1963. Lewis also directed the film. Hide Caption 10 of 22 Photos: The life and career of Jerry Lewis Lewis was the longtime spokesman for the Muscular Dystrophy Association. Here, Lewis visits President John Kennedy at the White House with Bobbie and Kerrie Whittaker, the 1963 national poster children for the association. Also shown, from left, are actress Patty Duke and the children's parents, Mr. and Mrs. C. Leigh Whittaker. Hide Caption 11 of 22 Photos: The life and career of Jerry Lewis Lewis tries out a Jerry Lewis special in 1971. The ice cream special was offered by a Troy, New York, pharmacy where Lewis worked as a young man. Lewis' former boss, Ben Silberg, helps eat the giant sundae. Hide Caption 12 of 22 Photos: The life and career of Jerry Lewis Lewis arrives at Nice Airport on his way to the Cannes Film Festival in 1979. Lewis was hugely popular in France, where in 1984 he was awarded the Legion of Honor, the country's highest tribute. Hide Caption 13 of 22 Photos: The life and career of Jerry Lewis Lewis with Robert De Niro in a scene from "The King of Comedy" in 1982. Lewis' part in the film was a rare serious role. Hide Caption 14 of 22 Photos: The life and career of Jerry Lewis Lewis married Sandra Pitnick in 1983. Hide Caption 15 of 22 Photos: The life and career of Jerry Lewis Lewis performs with the United States Army Reserve Band before receiving the the military's highest civilian award in 1985. The Medal for Distinguished Service was awarded to Lewis for his role in fighting muscular dystrophy. Hide Caption 16 of 22 Photos: The life and career of Jerry Lewis Lewis brings former CNN host Larry King to tears with a joke in 1999. Hide Caption 17 of 22 Photos: The life and career of Jerry Lewis Lewis wipes away tears at the 39th Annual Jerry Lewis MDA Labor Day Telethon in 2004. In 2011, Lewis and the Muscular Dystrophy Association announced they were parting ways. Hide Caption 18 of 22 Photos: The life and career of Jerry Lewis Lewis arrives for the Emmy Awards in 2015. Hide Caption 19 of 22 Photos: The life and career of Jerry Lewis In 2013, Lewis starred in the drama "Max Rose." He's shown here at the photo call for the movie at the Cannes Film Festival. Hide Caption 20 of 22 Photos: The life and career of Jerry Lewis Lewis holds up his cement covered hands during a 2014 ceremony to add his hand prints and footprints to the sidewalk at the TCL Chinese Theatre in Hollywood. Hide Caption 21 of 22 Photos: The life and career of Jerry Lewis Lewis and director Martin Scorsese attend a Friars Club event honoring Scorsese in New York in 2016. Hide Caption 22 of 22

Despite the acrimonious breakup, the two eventually reconciled, and Lewis and James Kaplan released a book in 2005 with a title that explained how Lewis saw the relationship: "Dean and Me (A Love Story)."

Upon their breakup, Martin was expected to be the greater success. He was an established singer and was beginning to make inroads as a respected actor, including performances in two 1958 films: "The Young Lions" (opposite Marlon Brando) and "Some Came Running" (with Frank Sinatra, with whom Martin would become longtime pals as part of the Rat Pack).

Lewis, on the other hand, was considered a lightweight, if crowd-pleasing, clown. His early solo films, such as "The Delicate Deliquent" (1957) and "Rock-a-Bye Baby" (1958), made under a longstanding contract with producer Hal Wallis, were more of the same.

That fool was no dummy. Jerry Lewis was an undeniable genius an unfathomable blessing, comedy's absolute! I am because he was! ;^D pic.twitter.com/3Zdq9xhXlE — Jim Carrey (@JimCarrey) August 20, 2017

The greatest is gone. RIP Jerry Lewis. — Stevie Van Zandt (@StevieVanZandt) August 20, 2017

But upon the end of his Wallis contract, in 1959, Lewis set out to take greater control of his work. He signed a huge contract with Paramount, a seven-year deal promising him $10 million and 60% of the profits for 14 films, according to his agency biography. He starred in "Cinderfella," written and directed by the noted comedy director Frank Tashlin, and -- when that movie was held for release -- came up with "The Bellboy," a silent-film-style story of pratfalls and adventures that Lewis wrote, directed and starred in.

It was for "The Bellboy" that Lewis first used video assist, so he could monitor his performance as he directed. He received a patent for the invention.

"The Bellboy" was released in July 1960 and was a hit, helping establish Lewis as an auteur. He exercised similar writing-directing-starring control over several successive films, including "The Errand Boy" (1961), "The Nutty Professor" (1963) and "The Patsy" (1964).

"The Nutty Professor" was perhaps the prototypical Lewis vehicle. A twist on Robert Louis Stevenson's "Dr. Jekyll and Mr. Hyde," the film starred Lewis both as nebbish professor Julius Kelp as well as smooth-talking boor Buddy Love, the man he turned into after drinking a strange potion. (More than one commentator has compared Love to Martin, Lewis' former partner, but the filmmaker regularly denied Martin was the basis for the portrayal.)

Lewis considered it his best film, and the American Film Institute ranked it as the 99th-best American comedy of all time. Eddie Murphy remade the film in 1996, and Lewis brought a musical version to the stage in 2012.

'Mozart of humor'

Comedian Jerry Lewis in 2013 at the Cannes Film Festival.

In 2015, the Library of Congress announced it had acquired a huge collection of films and documents from Lewis, including copies of his most popular films, home movies and spoof films made by Lewis at home, which sometimes starred neighbors such as Tony Curtis and Janet Leigh.

"For more than seven decades I've been dedicated to making people laugh. If I get more than three people in a room, I do a number," Lewis told the library. "Knowing that the Library of Congress was interested in acquiring my life's work was one of the biggest thrills of my life."

Though Lewis' humor sometimes left reviewers cold, he had a sizable fan base.

"My generation, we grew up on Dean Martin and Jerry Lewis. They were our heroes," said the late British funnyman Marty Feldman, crediting Lewis as one of the reasons he became a comedian. "Jerry Lewis actually has genius."

"Lewis is the Mozart of humor," wrote Agnes Poirier of the UK newspaper The Guardian in 2006. "You can keep sneering. I don't care."

Jerry Lewis loomed large in my family. Many movies with my mom & he made home movies with Janet and Tony. He made me and many laugh. #rip pic.twitter.com/4LbEbc9FCT — Jamie Lee Curtis (@jamieleecurtis) August 20, 2017

Lewis remained a box office attraction during the 1960s, but his popularity waned with changing tastes in comedy and some dismal films, such as "Way ... Way Out" (1966) ("About as funny and unusual as the daily trip on the subway," wrote The New York Times) and "Which Way to the Front?" (1970).

One attempt at an early-'70s film comeback, "The Day the Clown Cried" -- intended to be Lewis' first serious film -- became Hollywood legend.

In the rarely seen film, Lewis plays a circus clown, Helmut Doork, who ends up entertaining children at a concentration camp -- and eventually leads them to the gas chamber. The movie was never released but has been viewed by a select few, including comedian and "Simpsons" star Harry Shearer, who was blunt in his assessment.

"This movie is so drastically wrong, its pathos and its comedy are so wildly misplaced, that you could not, in your fantasy of what it might be like, improve on what it really is," Shearer told Spy magazine in 1992. "'Oh, my God!' — that's all you can say."

It was incredible knowing & laughing with the Amazing Jerry Lewis! He'll keep'em laffin in the ever after! — Samuel L. Jackson (@SamuelLJackson) August 20, 2017

Lewis rarely lacked for activity or money -- he performed regularly, including an annual Las Vegas gig that paid him well -- but he struggled to remain relevant. His 1980 comeback comedy, "Hardly Working," was given zero stars by Roger Ebert, who said it was "one of the worst movies ever to achieve commercial release in this country." (But it was a smash hit in Europe.)

In the 1980s and '90s, Lewis picked a handful of serious roles that earned him positive reviews. He played a kidnapped talk show host in Martin Scorsese's 1982 film "The King of Comedy," earning a BAFTA nomination for best supporting actor. He was a clothing business owner in a plotline on the late-'80s show "Wiseguy," and he played a wise comedy legend in the 1995 British film, "Funny Bones."

Lewis stayed active, touring and working periodically in TV and films. In 2013 he starred in the drama "Max Rose," and in 2016 he had a role in "The Trust," which starred Nicolas Cage and Elijah Wood. Both films were flops with critics, but RogerEbert.com's Glenn Kenny, in reviewing "Max Rose," said Lewis' performance was "full of virtues: He's committed, disciplined and entirely credible."

He helped raise billions

For many years, Lewis was most known for his work as the fundraising face of the Muscular Dystrophy Association.

He started his activity with MDA in 1951, according to his agency biography, although why he got involved has remained a mystery over the years. In 1956, he and Martin hosted an MDA telethon that raised $600,000. The first Labor Day Telethon, which was held in 1966 and aired only in the New York market, raised more than $1 million.

By 1973, the year the telethon moved to Las Vegas, it had a network of more than 150 stations and was raising more than $10 million.

Watched nutty professor over and over and over again as a kid. Got to meet and hang with clegend who made it. #jerrylewis. Rip — Russell Simmons (@UncleRUSH) August 20, 2017

The annual telethon, which aired live and ran for as long as 21½ hours, was filled with traditions. "Tonight Show" co-host Ed McMahon joined Lewis for many years and would cue up the band when the tote board hit another big number. (McMahon died in 2009.) Lewis welcomed hundreds of guests, including the entertainment flavor of the month, surprise stars -- John Lennon dropped by in 1972 -- or old friends: In 1976, he reunited with Martin, thanks to the intercession of mutual acquaintance Frank Sinatra.

And he was defiantly Lewis: clowning, raving, doing impromptu soft-shoes with the tie of his tuxedo undone. He traditionally concluded the broadcast with the Broadway standard "You'll Never Walk Alone."

In 2011, Lewis and the Muscular Dystrophy Association announced they were parting ways, and in 2015 MDA announced that there would be no more telethons, although Lewis worked with MDA in 2016 on a promotional video.

The "Jerry Lewis MDA Telethon" raised more than $2.4 billion, Lewis told the Las Vegas Sun in 2010. Lewis was awarded the Jean Hersholt Humanitarian Award from the Motion Picture Academy in 2009.

Success as a 'total idiot'

Lewis wasn't the picture of health. He survived prostate cancer and underwent open-heart surgery. He once smoked five packs of cigarettes a day, and -- because of medication -- once tipped the scales at close to 300 pounds. He developed dependencies on painkillers, which was related to a 1965 spinal injury suffered during a pratfall.

He also never lost his edge. Asked by "Inside Edition" in 2010 what he thought of troubled young Hollywood stars such as Lindsay Lohan, he let fly.

"I would smack her in the mouth if I saw her," he said. "And I would be arrested for abusing a woman." He added that he'd be happy to "put her over my knee and spank her."

Goodbye to the real, no irony, king of comedy. pic.twitter.com/t7qEkDo4Sl — Penn Jillette (@pennjillette) August 20, 2017

Last year he engaged in such a bizarre interview with The Hollywood Reporter that the publication headlined its article, "The most painfully awkward interview of 2016." Video of the exchange, in which a sullen Lewis rarely used more than three words to answer a question, went viral.

He could also be a soft touch, donating time and money to organizations such as the March of Dimes.

Lewis had six children, five sons and a daughter, by two wives. One son, Gary, became the lead singer of the 1960s pop group Gary Lewis and the Playboys.

Through it all, he never lost his outlook. "I've had great success being a total idiot," he once said, combining both ego and self-deprecation.

"You're still 9, right?" asked King in 2000.

"Oh, yes," replied Lewis. "I will cut your tie some night with a scissor."

Correction: An earlier story misstated the name of the deceased. Comedian Jerry Lewis has died at age 91, according to his publicist.