Leading sight loss charities Fight for Sight and Thomas Pocklington Trust partner to co-fund research into a little-known aspect of this disabling, long-term condition

Issued by Fight for Sight on 23 January 2015

Chronic fatigue syndrome (CFS) is well known for causing exhaustion. It’s also linked to a wide range of other symptoms such as pain, poor sleep and trouble concentrating. But despite the fact that people with CFS often report visual symptoms such as being very sensitive to light and having dry, itchy or painful eyes, little research has been done to understand exactly how and why the eye is affected. So Fight for Sight and Thomas Pocklington Trust have teamed-up to fund Dr Clare Hutchinson and co-investigator Dr Frank Proudlock at the University of Leicester to find out more about how the eye is affected in CFS.

People with CFS consistently report having trouble focussing on images, eye strain, vision-related headaches, slow eye movements and tracking moving objects, in addition to hypersensitivity to light and dry eye. So it’s possible that one or more of these symptoms experienced together with fatigue could be a defining feature of CFS. If so, it would make it easier for doctors to diagnose the condition, especially as none of the other symptoms people may experience are specific to CFS.

In this project, the research team will test 50 participants who have been diagnosed with CFS to get an objective picture of eye problems that may be linked to the condition. They’ll be looking for information such as how often and how severely dry eye occurs; how the participants’ pupils respond to light; how well they can focus on objects at different distances; clarity and depth of vision and the ability to perceive colour. The team will also scan images of the participants’ eyes to find out whether the shape of the eye is affected and examine the retina at the back of the eye which contains the photoreceptor cells that detect light. This information will be compared to results from a control group of 50 participants without CFS.

“Chronic fatigue syndrome is a debilitating disorder,” said Dr Hutchinson, Lecturer in the College of Medicine, Biological Sciences and Psychology at the University of Leicester. “Apart from disabling fatigue, there are few definitive symptoms of the condition. As a consequence, people with CFS often have difficulty gaining an appropriate diagnosis. As such, identifying distinct clinical features of CFS is an important issue and we are very pleased to have been awarded this grant to investigate the vision-related problems in CFS.”

Dr Dolores M Conroy, Director of Research at Fight for Sight, said: “It’s clear from patients’ self-reports that the visual problems they experience have a marked impact on their quality of life. They also represent distinct, quantifiable, clinical features that could significantly improve diagnosis, provide insights into underlying pathology and represent a candidate for treatment, thereby improving the everyday lives of patients. Fight for Sight is delighted to team up with Thomas Pocklington Trust to fund this important research project, results from which could contribute to visual symptoms being recognised as a key diagnostic feature of CFS.”

Sarah Buchanan, Research Director at Thomas Pocklington Trust, said: “Understanding the possible connections between health conditions, such as CFS, and people’s sight is important, not only in diagnosis but in understanding the interconnections of vision and wider health. As a sight loss charity we know the importance of good vision. But we also know that, all too often, it is overlooked when another health condition is diagnosed. That can mean opportunities to improve a person’s vision or reduce the problems they experience are missed. We are delighted to be working with Fight for Sight in considering vision within CFS and hope it may lead to other partnerships.”

For more information or images please contact:

Ade Deane-Pratt, Research Communications Officer, Fight for Sight.

E: ade@fightforsight.org.uk

Editor's Notes:

Fast facts

Chronic fatigue syndrome is also known as myalgic encephalomyelitis or ME. Myalgia means muscle pain and encephalomyelitis means inflammation of the brain and spinal cord.

About 250,000 people in the UK have CFS.

We don't yet know exactly what causes CFS but it may be due to a virus, the immune system, stress or hormonal imbalance. Anyone can be affected.

The National Institute for Health and Care Excellence (NICE) is the executive non-departmental public body of the Department of Health that provides national guidance and advice to improve health and social care.

About Fight for Sight:

1. Fight for Sight is the leading UK charity dedicated to funding pioneering research to prevent sight loss and treat eye disease.

2. Fight for Sight is funding research at leading universities and hospitals throughout the UK. Major achievements to date include:

saving the sight of thousands of premature babies through understanding and controlling levels of oxygen delivery

restoring sight by establishing the UK Corneal Transplant Service enabling over 52,000 corneal transplants to take place

providing the funding for the research leading to the world’s first clinical trial for choroideremia

bringing hope to children with inherited eye disease by co-funding the team responsible for the world’s first gene therapy clinical trial

identifying new genes responsible for keratoconus and Nance-Horan syndrome

3. Fight for Sight’s current research programme is focusing on preventing and treating age-related macular degeneration, diabetic retinopathy, glaucoma, cataract and corneal disease. We are also funding research into the causes of childhood blindness and a large number of rare eye diseases.

W: www.fightforsight.org.uk

Twitter: @fightforsightUK

Facebook: https://www.facebook.com/fightforsightuk

About Thomas Pocklington Trust:

Thomas Pocklington Trust is a national charity for people with sight loss. Its research programme commissions and funds social and public health research initiatives to identify ways to improve the lives of people with sight loss. www.pocklington-trust.org.uk