50 Cent has reignited his feud with son Marquise Jackson.

The In Da Club rapper took to Instagram on Thursday to comment on a photo of the 21-year-old posing with the son of longtime rival Kenneth 'Supreme' McGriff.

'If both these little n*****s got hit by a bus, I wouldn't have a bad day,' wrote the 43-year-old Get Rich Or Die Tryin' star.

Now, one day later, and 50 has taken to Instagram again to elaborate on his scathing comment. 'I have zero ill will towards anyone living on this Earth,' the rapper-turned-entrepreneur began.

Bad blood: 50 Cent -aka Curtis Jackson- took to Instagram on Thursday to comment on a photo of his son Marquise [R] posing with the son of longtime rival Kenneth 'Supreme' McGriff

'The people Shaniquas (50's baby mother) son looks up to and associates with is a reflection of the negative energy he embraces towards me,' 50 added in the caption of a promo photo from his Starz crime series Power, that shows him with a gun.

'I paid his mother $1,360,000 in support to afford him the opportunities I never had. They just spent it, over the years I repeated get a job now they have to figure it out.'

The dispute dates back to 2000, when 50 Cent was shot nine times outside his grandmother's former home in South Jamaica, Queens, New York.

Another take: 50 took to Instagram on Friday to elaborate on his scathing comments: 'I have zero ill will towards anyone living on this Earth... The people Shaniquas (50's baby mother) son looks up to and associates with is a reflection of the negative energy he embraces towards me'

Happier times: The rapper clearly didn't take kindly to his own flesh and blood posing with McGriff's son - especially given the pair already have a strained relationship. 50 Cent seen here with Marquise in 2007

Federal investigators at the time believed the mastermind behind the attack was New York drug kingpin Kenneth 'Supreme' McGriff.

The rapper survived the attack, despite being shot in the hand, arm, hip, both legs, chest and left cheek.

And 50, whose real name is Curtis James Jackson, clearly didn't take kindly to his own flesh and blood posing with McGriff's son - especially given the pair already have a strained relationship.

'Father's Day Lunch lol': On Father's Day 2018, Marquise trolled his dad with an Instagram post in which he posed while sitting alone at a restaurant behind two empty plates

On Father's Day 2018, Marquise trolled his dad with an Instagram post in which he posed while sitting alone at a restaurant behind two empty plates.

The post was captioned 'Father's Day Lunch lol,' in an apparent jab at his absent father.

50 Cent shares his firstborn with Shaniqua Tompkins, 43, who famously sued the actor for $50 million, over her claims they had made an oral agreement that he would take care of her financially for life.

The suit was tossed in 2009.

Got rich: 50 Cent shares his firstborn with Shaniqua Tompkins, 43, who famously sued the actor for $50 million in 2009. 50 seen here in October 2018

The dispute dates back to 2000, when 50 Cent was shot nine times outside his grandmother's former home in South Jamaica, Queens, New York in an attack orchestrated by Kenneth 'Supreme' McGriff, according to federal investigators. McGriff seen here in 2007

Marquise spoke about his strained relationship with the I Get Money artist in a 2017 interview with Rap Up.

'It completely went south when I was probably like 10 or 11. He wasn’t really around enough,' revealed the aspiring rapper.

And things have since gone from bad to worse between the pair.

'He’s still alive but I can’t tell you our last conversation or the last time we even had a dialogue,' said Marquise.

50 Cent also has another son, six-year-old Sire Jackson, with actress Daphne Joy.