The UFC Chile card set for May 19 has been dealt a pair of devastating blows.

Santiago Ponzinibbio is out of the main event scheduled to be against Kamaru Usman on May 19, sources told MMA Fighting's Ariel Helwani. The UFC is working to find a replacement, though Usman says he won't accept a bout if the new opponent is unranked.

In addition, the fight between Mauricio "Shogun" Rua and Volkan Oezdemir has been taken off the card with hope of moving it to a date later this summer, reports Helwani. Oezdemir currently has a pending felony battery charge over an alleged incident outside a Florida bar last summer. Combate was first to report the development in March.

The card still includes two matchups between ranked opponents in a women's strawweight bout between Alexa Grasso and Tatiana Suarez, and a flyweight fight between Ray Borg and Brandon Moreno.

Ponzinibbio is on a six-fight winning streak, most recently defeating Mike Perry last December and is currently 10th in the UFC's welterweight rankings. Usman, the seventh-ranked welterweight, is on an 11-fight winning streak.

Rua hasn't fought since picking up a win via TKO over Gian Villante in March 2017, but is currently riding a three-fight winning streak. Oezdemir is coming off a loss to Daniel Cormier for the light heavyweight title in January and sits as the second-ranked contender in his division behind Alexander Gustafsson.