The first crewed mission is Artemis 2, currently slated for 2022.

The capsule is a relatively complex beast. It has enough survival equipment for 21 days of active crew time, a modern cockpit, automatic docking and a whopping 12 engines. It needs that volume of equipment, though. It's meant to be the main crew vehicle not just for Artemis, but for possible asteroid and Mars missions. It needs to be adaptable in ways that even capsules like Crew Dragon haven't mustered so far.