Already a hit show on Cartoon Network, “Metalocalypse” has been responsible for a heavy metal album that debuted at #21 on the Billboard Top 200 and is now getting a follow-up. The show has also spawned a song for the "Guitar Hero" franchise and comic books.

Now comes the videogame, to be announced later this week by Cartoon Network and Konami at San Diego Comic-Con. Brendon Small, the show’s creator, worked with Konami to produce “Metalocalypse: Dethgame” as a downloadable title for Microsoft’s Xbox 360 and Sony's PlayStation...