Guide by: ofuro28. Click here to go to the original source.

Some ToC:

In this post I want to make a rough guidance -a rule of thumb- about which monsters that can use specific runes.

Please take it with pinch of salt

I only want to emphasize on slot 2/4/6

I make this post with end-game stage on mind.

Resistances on slot 6 is immediate sell

Flat stats is immediate sell

Always sell any non-6stars rune you got except 5stars slot 2 spd, or you got it with 4 crazy substats

What I bold is the premium runes, you should be grateful if you got one

Also I won’t emphasize too much on monster that got special rune build or monster that a bit falls through on end game

Monster Classification

Before we starts, I want to classified some of monsters as:

Raw DD (RDD) : usually this type of monster relies on one of their skills (usually their 2nd or 3rd skills) as their sources of damage: lushen, katarina, kahli, etc

violent DD (VDD) : this type of monster potential increase with violent rune: camilla, kahli, raoq, guillaume, all chimeras, perna, tyron, etc

speed DD (SDD) : a type of damage dealer that increasing his damage according to aspd : all samurais, theomars, tesharion, hwa, etc

HP-based DD (HPDD) : DD that benefit greatly from his HP: eshir, vigor, beast monks, darion, jubilee (as pointed by /u/TaiserRY)

DEF-based DD (DEFDD) : DD that benefit greatly from his DEF : groggo, velajuel, dark archangel

SS – Support that want to Recycle their skills fast or support that benefit greatly from speed : chasun, veromos, eladriel, briand, shannon

Speed Demons (SD) – monster that you want to be the fastest one no matter what : megan, bernard, chloe, verde

Crowd-Control (CC) : Debuffer team: tyron, barreta, aria, thrain, etc

Bomber (BOMB) : water wind light kobold, and fire dark joker

TANK : self-described

Runes

So let’s start with the runes

Energy (HP +15%)

slot 2 spd : not the 1st choices, but can be used on SS or SD

slot 2 hp% : can be 1st choices for any tank type

slot 2 atk% : good for anavel or any atk-based healer monster. good runes for bomber also if you can keep the acc high enough through substats

slot 2 def% : sell

slot 4 hp% : can be 1st choices for any tank type

slot 4 atk% : see slot 2 atk%

slot 4 def% : sell

slot 4 critr% : can be 1st choices for ahman, if you can reach 100critrate through substats with violent/energy build

slot 4 critd % : can be 1st choices for vigor/eshir, if you can reach high critrate through substats with rage/energy build

slot 6 hp% : can be 1st choices for any tank type

slot 6 atk% : see slot 2 atk%

slot 6 def% : sell

slot 6 acc% : not the 1st choices, but can be use on any CC if you can keep 85 acc through subs on violent/energy or despair/energy set

Blade (Critical Rate +12%)

slot 2 spd : 1st choices for SDD, can also be useful for verd if you can’t hit 100critR through substats

slot 2 hp% : 1st choices for HPDD

slot 2 atk% : 1st choices for RDD, VDD

slot 2 def% : 1st choices for DEFDD

slot 4 hp% : sell, or you can keep it if you want broken sets for tank

slot 4 atk% : sell, or you can use it for BOMB

slot 4 def% : sell

slot 4 critr% : 1st choices for ahman, verd. don’t use it for any DD

slot 4 critd % : 1st choices for any DD

: 1st choices for any DD slot 6 hp% : 1st choices for HPDD

slot 6 atk% : 1st choices for RDD, VDD, SDD

: 1st choices for RDD, VDD, SDD slot 6 def% : 1st choices for DEFDD

slot 6 acc% : good for orochi, and mikene if you can reach 85acc and 100critr using violent/blade set

Focus (Accuracy +20%)

slot 2 spd : 1st choices for megan, bernard, and CC

slot 2 hp% : sell, or you can keep it if you want broken sets for tank

slot 2 atk% : 1st choices for bomber

slot 2 def% : sell

slot 4 hp% : 1st choices for CC, or you can use it as broken sets for tank

slot 4 atk% : 1st choices for bomber

slot 4 def% : sell

slot 4 critr% : 1st choices for orochi / mikene

slot 4 critd % : sell

slot 6 hp% : 2nd choices for CC (only if you can get 85 acc through subs). or you can use it as broken sets for tank

slot 6 atk% : 1st choices for bomber

slot 6 def% : sell

slot 6 acc% : 1st choices for CC

Fatal (Attack Power +35%)

There is a post regarding whether you should use fatal or rage, but for now, I assume that you can get at least 55 critR which is better to use rage than fatal

slot 2 spd : sell, or can be mediocre sets for SDD

slot 2 hp% : sell

slot 2 atk% : 1st choice for bomber, or can be mediocre sets for VDD, RDD

slot 2 def% : sell

slot 4 hp% : sell

slot 4 atk% : 1st choice for bomber

slot 4 def% : sell

slot 4 critr% : sell

slot 4 critd % : sell, or can be mediocre sets for VDD, RDD, SDD

slot 6 hp% : sell

slot 6 atk% : 1st choice for bomber, or can be mediocre sets for VDD, RDD, SDD

slot 6 def% : sell

slot 6 acc% : sell

Rage (Critical Damage +40%)

slot 2 spd : 1st choices for SDD

slot 2 hp%: 1st choices for eshir

slot 2 atk% : 1st choices for RDD

: 1st choices for RDD slot 2 def% : 2nd choices for DEFDD (after violent)

slot 4 hp% : sell, or can be use as broken sets for tank

slot 4 atk% : sell

slot 4 def%: sell

slot 4 critr%: sell

slot 4 critd % : 1st choices for SDD, HPDD, RDD, DEFDD

: 1st choices for SDD, HPDD, RDD, DEFDD slot 6 hp%: 1st choices for eshir

slot 6 atk% : 1st choices for RDD, SDD

: 1st choices for RDD, SDD slot 6 def% : 1st choices for DEFDD

slot 6 acc% : sell

Swift (Attack Speed +25%)

slot 2 spd : 1st choices for SD, and SDD

: 1st choices for SD, and SDD slot 2 hp% : 2nd choices for SS

slot 2 atk% : sell

slot 2 def% : sell

slot 4 hp% : 1st choices for SD, 2nd choices for SS

slot 4 atk% : sell

slot 4 def% : sell

slot 4 critr% : best rune for verde (as pointed by /u/Uberlox) , otherwise sell

slot 4 critd % : 2nd choices for SDD

slot 6 hp% : 1st choices for SD or 2nd if the monster need acc

slot 6 atk% : sell

slot 6 def% : sell

slot 6 acc% : 1st choices for SD if the monster need acc

Guard (Defense +15%)

slot 2 spd : can be good for SD or CC, but definitely not 1st choice

slot 2 hp% : good enough for tank, but not 1st choices

slot 2 atk% : sell

slot 2 def% : 2nd choices for DEFDD if you can get lots of critR from violent/guard or rage/guard set. 1st choices for copper though

slot 4 hp% : good enough for tank, but not 1st choices

slot 4 atk% : sell

slot 4 def% : 1st choices for copper

slot 4 critr% : sell

slot 4 critd % : pls see slot 2 def%

slot 6 hp% : pls see slot 2 hp%

slot 6 atk% : sell

slot 6 def% : pls see slot 2 def%

slot 6 acc% : sell

Endure (Resistance +20%)

slot 2 spd : can be good enough for SD, but definitely not 1st choice

slot 2 hp% : good enough for tank, but not 1st choices

slot 2 atk% : sell

slot 2 def% : good enough for DEFDD , but not 1st choices

slot 4 hp% : see slot 2 HP%

slot 4 atk% : sell

slot 4 def% : sell

slot 4 critr% : sell

slot 4 critd % : good enough for DEFDD or HPDD, but not 1st choices and only if you can get high enough critR

slot 6 hp% : see slot 2 HP%

slot 6 atk% : sell

slot 6 def% : see slot 2 def%

slot 6 acc% : sell

Violent (Get Extra Turn +22%)

The best 4-rune sets in the game, nuf said

slot 2 spd : 2nd choices for SDD after swift, 1st choices for non-despair CC, 1st choices for SS (if you can get high enough HP)

slot 2 hp% : 1st choices for tank. 1st choices for HPDD (except eshir), 1st choices for SS (if you can’t get high enough HP)

: 1st choices for tank. 1st choices for HPDD (except eshir), 1st choices for SS (if you can’t get high enough HP) slot 2 atk% : 1st choices for VDD

slot 2 def% : 1st choices for DEFDD

slot 4 hp% : 1st choices for tank, non-despair CC, SS

slot 4 atk% : 1st choices for anavel, or sell it if you dont have anavel

slot 4 def% : sell

slot 4 critr% : 1st choices for ahman, orochi, mikene.

slot 4 critd % : 1st choices for VDD. 2nd choices for SDD after swift, 2nd choices for HPDD after rage

slot 6 hp% : see slot 2 HP%

: see slot 2 HP% slot 6 atk% : 1st choices for VDD, 2nd choices for SDD after choices

slot 6 def% : see slot 2 DEF%

slot 6 acc% : 1st choices for non-despair CC

Despair (Stun Rate +25%)

slot 2 spd : 1st choice for CC

slot 2 hp% : 2nd choices (after violent) for briand, arnold.

slot 2 atk% : 2nd choices for DD that got AoE : lushen (after rage), sig (after violent),

slot 2 def% : 1st choices for artamiel, wind mk despair-revenge. also 1st choices for copper

slot 4 hp% : see slot 2 HP%, also 1st choices for CC

slot 4 atk% : sell

slot 4 def% : 1st choices for copper

slot 4 critr% : sell

slot 4 critd % : see slot 2 def% or slot 2 atk%

slot 6 hp% : see slot 2 HP%, also 1st choices for CC if you get enough acc from substat

slot 6 atk% : see slot 2 atk%

slot 6 def% : see slot 2 def%

slot 6 acc% : 1st choices for CC if you don’t get enough acc from substats

Nemesis (ATK Gauge +4% (for every 7% HP lost))

I won’t talk a lot about nemesis, since from my observation, only handful of monster can use nemesis to its full extent, with examples:

camilla with atk/critd/atk violent/nemesis

chasun with spd/hp/hp or hp/hp/hp violent nemesis

ramagos with hp/hp/hp vampire/nemesis

As pointed by /u/papagelos and /u/JohtoKan actually veromos is indeed another monster that can benefited greatly from nemesis using: violent-nemesis spd/hp/hp or hp/hp/hp

Shield (Ally Shield 3 turns (15% of HP))

As a rule of thumb, shield works greatly if you got more base-HP%. Therefore this rune works great on hi-base HP monster, and can act as replacement 2-rune set if you find the stats and substats are much better than the most intended set.

Revenge (Counterattack +15%)

As a rule of thumb, revenge works great on monster that is not squishy, and got some special 1st skill effect

slot 2 spd : good on offensive tyron, raoq, bella

slot 2 hp% : darion, jultan, jubilee, talc, basalt. also good on any despair-revenge HP%/HP%/HP% tank monster, also good on HPDD monster

slot 2 atk% : camilla on violent revenge, wind mk on despair revenge

slot 2 def% : DEFDD if you can retain high critR

slot 4 hp% : see slot 2 HP%

slot 4 atk% : good for anavel, otherwise sell

slot 4 def% : sell

slot 4 critr% : good for verd if you can maintain 100% critr on swift/revenge

slot 4 critd % : see slot 2 atk%, also good on DEFDD if you can retain high critR

slot 6 hp% : see slot 2 HP%

slot 6 atk% : see slot 2 atk%

slot 6 def% : see slot 2 def%

slot 6 acc% : sell

Vampire (Life Drain +35%)

I wont describe in detail but vampire is good on:

ramagos on vampire-nemesis on HP%/HP%/HP% or vampire-energy HP%/HP%/HP%

for farmer, such as susanoo, liesel, to name a few.

Will (Immunity +1 turn)

As rule of thumbs:

best will user is chloe with swift/will, spd/hp/hp and with crazy spd everywhere. so keep an eye for that 😀

will is also good on cleanser, such as kona, fedora, delphoi with violent-will spd/hp/hp, also good on velajuel on violent-will def/critd/def

zeratu and rakan is another good will user with violent-will atk/critD/atk

otherwise, you can use will on your DD (if you can get high critR and critD), to counter tyron and zaiross team on PvP

In the end I hope this would be useful for some 😀

Cheers