Using ketamine can be fun, and recent studies have shown it to have antidepressant effects. (1) But using it too often can damage your bladder and result in a serious condition known as Ketamine Bladder Syndrome (a.k.a. Ketamine Cystitis). Your bladder is a round sac behind your pelvic bone that holds urine. It is about the size of a grapefruit, but can ... Read more