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Donald Trump Jr.'s wife is filing to divorce him after nearly 13 years of marriage.

Vanessa Trump filed docs Thursday in the Manhattan courts, and she's seeking an uncontested proceeding. That's a strong sign the couple has already hammered out details of their split, such as child custody and property.

Sources connected to the family tell TMZ the divorce has been a long time coming, and the relationship has been "bad for a while." Among the issues, Vanessa "hates politics and Don Jr. is gone all the time."

One source says contrary to being upset, Don Jr. is "relieved."

They have 5 children together -- between the ages of 3 and 10, and got married in 2005.

According to the NY Post, which first reported the split, Vanessa's been upset about some of his controversial tweets ... most of which defend President Trump and his policies.

Vanessa got a major scare just last month, when she received an envelope with white powder, and a hate letter for Don Jr. that read, in part, "You the family idiot. This is the reason why people hate you. You are getting what you deserve." The powder turned out to be corn starch, and the sender was eventually arrested.