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Well, for my group, we get pretty silly without the alcohol. We really don't need anything lowering our inhibitions when we play.

Also, not everyone is the same kind of 'drunk', after having a few. You've got your 'angry drunks', 'sappy drunks', and 'happy drunks', and lets not forget the 'horny drunk'. Many of these types, and D&D, really don't mix well. I'd hate to be a player under an 'angry drunk' DM.

For some folks, alcohol can be a bit of a soporific, or downer. D&D relies on creativity, and paying attention to what is going on in the game. Tough to do when you're falling asleep in your chair.

For my regular group of 8, six of them drink outside the game, when they choose to. One is a Muslim, thus it is against his religion. The other, myself, is allergic to grain based alcohol, so there's isn't much I can imbibe. (Can you imagine bringing a bottle of wine to your D&D table? Talk about odd looks!)