Chelsea Clinton made quick work of a Fox News contributor's asinine comment about her mother Hillary on Saturday afternoon.

Lisa Marie Boothe appeared as a guest host of 'The Five' Friday night, and used her spot on the cable news network's popular primetime show to make a horribly offensive remark about Hillary and her desire to be commander-in-chief.

She kicked things off by calling Hillary 'the most soulless woman on this planet', and then went on to say that the former Secretary of State 'would literally sell her daughter to be president'.

Boothe then made a point of punctuating her comment by adding: 'Sell her only child to be president. I mean, that's how much she wants it.'

She persisted.

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Literally Lisa: Fox News contributor Lisa Powers Boothe (above) said on 'The Five' that Hillary Clinton 'would literally sell her daughter to be president'

Bye girl: 'No, she wouldn't. I've never doubted & always known I was the most important part of her life,' said Chelsea Clinton on Twitter hours later (above)

Chelsea was in no mood to suffer fools while on holiday however, and quickly let her wraith rain down upon Boothe from across the Atlantic.

'No, she wouldn't. I've never doubted & always known I was the most important part of her life,' said Chelsea.

'Now as a mom I'm even more grateful to my mom .'

Chelsea chose not to address Boothe's remarks beyond that, or share any of the harrowing statistics regarding mothers who actually do sell their children, with most of those young girls ending up trafficked as sex slaves.

Boothe meanwhile has been keeping a low profile since Friday night, with the commentator heading out to Montauk on the tip of Long Island over the weekend.

She made her remarks about Hillary during a segment on Donald Trump Jr's meeting with a Russian lawyer, which is the latest offense to hit the scandal-plagued Trump administration.

The actual details of the June 2016 meeting were quickly tossed out, at which point the hosts began to weigh in on the matter.

Boothe took issue with the most unlikely of people when it was her turn to chime in Hillary's former campaign manager Robbie Mook.

Mook tweeted after news of the scandal broke in full on Monday: 'Question is no longer whether the Trump campaign was seeking Russian help, but if they had a role in the Guccifer 2 email drop days later.'

He then added: 'What did the President know and when did he know it?'

Friends and family: She also added: 'Now as a mom I'm even more grateful to my mom'

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Mook was previously attacked by Donald Trump Jr. in July of last year for saying Russia had been attempting to meddle in the election, with President Trump's namesake calling the Democratic operative 'disgusting'.

Boothe had no choice but to use him as her whipping post if she wanted to bring Hillary and Chelsea into the story due to the fact that neither of the women have made any public comment about the incident.

'I just think there's a little bit of irony here that these people are supposed to be the voices of authority on morality or...what's ethical or not, given some of the people they worked for,' said Boothe.

Chelsea meanwhile took some time away from her family vacation to also engage with some of the mothers who commented on her Twitter post, speaking more about her love and admiration for Hillary and her own children, Aidan and Charlotte.