PHILADELPHIA — Rodney Hood scored a game-high 25 points, including a dagger 3-pointer with less than three minutes left in the fourth quarter, as the Cleveland Cavaliers handed the Philadelphia 76ers their first home loss of the season, 121-112 on Friday at Wells Fargo Center.

It was Cleveland’s third victory in 17 games, snapping a three-game losing streak. Philadelphia had not lost a regular season home game since March 16, a span of 20 games.

Hood’s fadeaway three with 2:55 remaining gave Cleveland a 15-point lead, and a tip-in by Jordan Clarkson kept the Sixers at bay as the clock ticked under two minutes to play.

Rodney puts the 🍒 on top!



It's been that kinda night for the @cavs on FSO & the FOX Sports app: https://t.co/mXVg9BJ3e0#BeTheFight | #CavsSixers pic.twitter.com/b9Ft7pfMhB — FOX Sports Ohio (@FOXSportsOH) November 24, 2018

Clarkson, who did not score until less than a minute was left in the third period, came off the bench to tally 19 points on 8-of-15 shooting, including a pair of 3-pointers. Cleveland’s bench, which did not score a point until a Larry Nance Jr. dunk with under a minute in the third, outscored Philadelphia’s reserves 28-17.

Cleveland coach Larry Drew said his team did a good job of executing on offense and taking care of the basketball. Cleveland committed just eight turnovers, only one in the fourth quarter. But Drew said the difference was Cleveland’s ability to sustain its effort throughout.

“We were able to sustain for four quarters, which we have not been able to do this year,” Drew said. “Tonight we were able to start it and finish it in a real positive note.”

Cleveland is 12-2 in its last 14 games against the Sixers, including a 6-1 mark on the road.

Drew said the Cavs are not going to look at their record and count themselves out of any game, regardless of the competition.

“We’ve had some really close games and games we felt we should have won,” Drew said. “We knew coming in to this building that it was going to be a tough task. They’re a good team. They’re well-coached. They’ve got three guys that will probably be all-stars. We knew we had to be on-point with everything we did on both ends of the floor.”

Rookie Collin Sexton scored 23, one off his career-high, and dished out three assists. Cedi Osman finished with 20 points including a pair of 3-pointers. Tristan Thompson added 18 on 8-for-14 shooting with a game-high 13 rebounds, including 11 in the first half.

Third-year guard Andrew Harrison, signed to a two-way contract from Memphis earlier this month, played 17 minutes, including some big minutes in the fourth quarter while Sexton rested. Harrison’s 3-pointer with 5:12 left in the fourth put Cleveland ahead 104-95 and forced Philly coach Brett Brown to call a timeout.

“He had a terrific fourth quarter,” Drew said of Harrison. “He was good on both ends. He did a really good job getting us into our offense and just making plays. He made the right plays going down the stretch.”

After struggling throughout most of the season in the first quarter, the Cavaliers put together their second consecutive strong opening frame, outscoring the Sixers 31-23 after leading by as many as 14. Sexton scored 10 on 5-of-7 shooting and Osman led all scorers with 12, including a pair of 3-pointers.

Philadelphia tied the game at 54 at halftime, as Joel Embiid tallied eight in the second quarter and JJ Reddick added seven. Embiid led the Sixers with 24 points and 12 rebounds, but was hounded early with double-teams, creating three turnovers and frequently forcing the ball out of the All-Star center’s hands.

Brown said Embiid struggled early on, but then settled in.

“I think we can help Joel, with maybe quicker, better spacing, but I give Cleveland credit in causing some confusion with the double teams,” Brown said.

Next: The Cavaliers return to Quicken Loans Arena to host Chris Paul and the Houston Rockets on Saturday at 7:30.