Posted 06 December 2013 - 02:03 PM

My supplier wont deal with stimulants. Focalin is weak for ADD from what I've heard. Plus it has a short half life.



If your goal is to get high there are plenty of other RCs I've see.



Oh that sucks. Is it just a general stimulant policy, or specifically things that might fall under the analog act? In the case of these Modafinil derivatives you're getting pretty far aware from anything remotely schedule 1/2. Remember even alpha-ethyltryptamine didn't even count as a DMT analog before it was specifically scheduled (from the US v. Forbes case).As far as CHEMBL365227, I've been looking for a reasonably selective DRI with higher potency than Modafinil for a while. Not so much for getting high, as for being productive. Focalin is indeed fairly well garbage, but CHEMBL365227 shows every indication on paper of being significantly better. CHEMBL365227 probably has a decently long half life, considering Modafinil primarily undergoes decarboxylation. CHEMBL365227 is also ~13.4 times as potent as a DRI as Focalin, but only ~5 times as potent an NRI. I'd think it would be subjectively similar in stimulant effect to taking Modafinil and Selegiline with a low dose of Dexedrine.Now moving back across the blurry line between stimulants and eugeroics, I've dug up a few more interesting things.Cephalon's third paper had a real oddball in it. They accidentally discovered "Compound 3" was responsible for the effects of some of the others, and tested it at 139% the eugeroic potency of Modafinil with 2.4x less affinity for the dopamine transporter. Now that's strange enough in and of itself, but take a look at the structure:It's Fluorenol aka 9-Hydroxyfluorene! TIL Fluorenol is a fairly potent eugeroic, I guessIt metabolizes into Fluorenone. I haven't looked too extensively into safety, although acute toxicity does not seem to be an issue. Sure would make an odd nootropic, huh?Interestingly Cephalon's old site mentions a drug called CEP-16233 as an "atypical-psychostimulant" and CEP-26401 as an H3 antagonist. Going through other publications by some of the authors on the "Search for the next generation modafinil" series has yielded a few interesting results including a new series of 5-HT6 antagonists . I highly suspect CEP-16233 is either of the compounds mentioned in my original post, more likely "compound 2" and that the structure was only publicized as a eugeroic last year. Looks like CEP-26401 is probably in here too.This looks like a very interesting article on more modafinil derivatives from the english abstract, although unfortunately I can't read Chinese: http://www.ncbi.nlm....pubmed/23724650 I tried plugging it into google translate, and it makes absolutely no sense. All I can gain is mice move around more on "compound 6h" than Modafinil.Anyone who can read chinese care to give a quick summary of what compounds they made, and with what effect?I'll be getting some sleep now, as I still haven't found a powerful enough eugeroic to fully eliminate my need for it, but I'll pick up my search tomorrow and dig deeper into literature. "Compound 2" is looking like a real winner thus far. I still bet there are even more potent ones out there, from what I've seen the surface has barely been scratched on the 2-substituted modafinil derivatives.