Mitchell Marsh has been ruled out of the rest of Australia's VB one-day series against Pakistan due to injury, while star fast bowler Mitchell Starc and batsman Chris Lynn will both miss the third match of the series in Perth on Thursday.

Australia and Brisbane Heat star Lynn has finally succumbed to a bulging disc in his neck and will return to Brisbane to see a specialist, where his availability for the final two matches of the series will be assessed. Starc has been rested and won't fly to Perth with his teammates tomorrow, but will instead join them in Sydney for the fourth match of the series.

Marsh, who was today named in Australia's Test squad for the Qantas Tour of India next month, has been battling an ongoing right shoulder complaint that has restricted his ability with the ball.

"Mitchell has had an ongoing shoulder injury which we have been managing but it is now at a point where he is unable to function at the level required. He now requires a period of rest and rehabilitation in order to return to full fitness," said Bupa Support Staff Physiotherapist David Beakley.

Victoria's rising Test star Peter Handscomb has been added to the one-day squad for the third match in Perth on Thursday as a replacement for Lynn, while a replacement for Marsh is expected to be named tomorrow.

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Handscomb's call-up is a blow for the KFC Big Bash League leaders Melbourne Stars ahead of their top-of-the-table clash with the Brisbane Heat on Tuesday. However, the Stars will have the services of leg-spinner Adam Zampa to call upon after he was released by Australia to play in Tuesday's match.

Zampa will rejoin the ODI squad in Perth on Wednesday where he will be hoping to not make it five straight ODIs mixing drinks after he was again left out of the XI for Australia's six-wicket defeat at the MCG on Sunday night.

Handscomb has been on a metoric rise since being elevated into Australia's Test XI in November. He was one of three new faces after sweeping changes to the Test team following an innings hiding by South Africa in Hobart. He has scored two fifties and two centuries in his four Tests, and currently boasts an average of 99.75.

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Australia had foreshadowed before the series that key bowlers Starc and Josh Hazlewood would be rested at some point, with the latter having missed the opening match in Brisbane. It opens the door for towering Queenslander Billy Stanlake to return to the XI after making his ODI debut in Brisbane where he was troubled by illness.

Interim National Selector Trevor Hohns said: "Mitchell has had a very big six months and played a significant amount of cricket. We needed to find an opportunity to give him a break and with his schedule in the comings months we believe now is the appropriate time to give him a match off."

Lynn has been one of the stories of the summer and his big-hitting right-hander's heroics in the BBL|06 launched him into Australia's one-day side for the first time.

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But just two days after he made his ODI debut at the Gabba, Lynn has reaggravated his existing neck injury.

"Unfortunately Chris has re-aggravated his existing neck injury and is currently unable to function at a level required to play a match," Beakley said.

"He will not travel with the squad to Perth, and will instead return to Brisbane tomorrow to be reviewed by his specialist.

"Following that consultation and seeing how he responds to treatment we will be able to determine whether or not he can take part in the remaining two one-day international matches in Sydney and Adelaide."

Lynn has been cursed by a series of shoulder problems over the years and there was initial suspicion that the pain he was experiencing in his neck and shoulder was related to his previous injuries.

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But he revealed earlier this month that doctors had diagnosed the cause of the pain and the Queenslander was optimistic that he could push through the injury.

"The docs have come to the conclusion that I've got a bulging disc in my neck (and) it's just pushing against the nerve," Lynn said last week, adding that he was "on some pretty good drugs" in order to lessen the pain.

"I'm trying not to think about it. The more you think about it, the more pain it gives you."