A Sydney man has been charged with murdering his own nephew in western Sydney earlier this year.

Police allege 47-year-old Abdel Dwikat shot his 23-year-old nephew, Saif Jouda, multiple times in the face at a home in Horsley Park in April, after he answered a late-night knock at the door.

Early Friday morning, police arrested the man at Byron Street in Yennora after an investigation from Strike Force Interface, comprised of police from Fairfield Local Police and the State Crime Command's Homicide Squad.

He was taken to Fairfield Police Station where he was charged with murder.