A man has been shot in the calf in a Sydney street and taken to hospital in a serious condition.

Police and paramedics were called to Hollywood Drive, Lansvale, in south-west Sydney about 1.45pm on Monday.

"The 22-year-old man was shot in the calf inside a home unit and has been taken to Liverpool Hospital for treatment," a police spokeswoman said.

Detectives from Cabramatta Local Area Command have established a crime scene and are conducting inquiries into the incident.

A NSW Ambulance spokesman said the victim was in a serious condition. The man is known to police.

The attack follows a number of shootings in western Sydney in recent weeks and six shooting murders in the area since August.

Police said it was too early to say if there was a link between this incident and the other shootings. Police will release a statement shortly.

AAP and Ilya Gridneff

