Rosie O’Donnell appears to have another foe in Washington, with the former “View” co-host slamming House Speaker Paul Ryan Paul Davis RyanAt indoor rally, Pence says election runs through Wisconsin Juan Williams: Breaking down the debates Peterson faces fight of his career in deep-red Minnesota district MORE (R-Wisc.).

The comedian wrote to her more than 900,000 followers on Twitter on Friday: “f--- you paul ryan – shame.”

The tweet came as a reply to one from “Strangers With Candy” actress Sarah Thyre, who dropped the F-bomb in her own post about Ryan, writing, “Dear @SpeakerRyan: F--- you. Love, me and @pussyrrriot,” along with a video called "Straight Outta Vagina."

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She sent the tweets as Ryan presided over a joint session of Congress to verify Electoral College votes and a day after the Speaker announced GOP lawmakers would move to cut federal funding for Planned Parenthood.

O’Donnell has famously long-standing feud with President-elect Donald Trump Donald John TrumpBarr criticizes DOJ in speech declaring all agency power 'is invested in the attorney general' Military leaders asked about using heat ray on protesters outside White House: report Powell warns failure to reach COVID-19 deal could 'scar and damage' economy MORE. She recently called him “mentally unstable.”

The war of words is believed to have stemmed from remarks O’Donnell made in 2006 on “The View,” criticizing Trump’s comments about a contestant in his Miss USA pageant. The real estate mogul has called O’Donnell a “pig” and a “loser.”

O’Donnell, 54, is poised to join a number of Broadway stars on Inauguration Day at a concert in New York benefitting human rights organizations. Among the stars slated to appear at the Concert for America: Rosie Perez, Bebe Neuwirth, Betty Buckley, Chita Rivera, and Brian Stokes Mitchell.

Proceeds from the event are poised to go to groups including Planned Parenthood, the Sierra Club and the Southern Poverty Law Center.