I can't really think of any way this day could have gone worse for Buffalo, not without a surprise appearance by J.P. Losman in the fourth quarter.

The team's revamped defense allowed a million points and yards to the Jets, a team that couldn't buy a TD in the preseason, and quarterback Ryan Fitzpatrick was a disaster (three interceptions, and he tried to throw more). But here's the worst news: Fred Jackson suffered a knee injury in the first half. He was done for the day. The early word is that Jackson sprained his lateral collateral ligament; he's scheduled for a Monday MRI.

[Also: Jets deliver crushing defeat to previously optimistic Bills]

The injury occurred when LaRon Landry drilled Jackson just above the left knee, sending the veteran running back to the turf, rolling out of bounds. Ugly stuff.

In Jackson's absence, C.J. Spiller had a huge day. Because that's what he does. Spiller finished with 194 scrimmage yards, and he scored the Bills' only first-half TD on a 56-yard run. You might recall that Spiller was actually the highest-scoring back in fantasy over the final three weeks last season, starring when Jackson was sidelined with a fractured leg. He's unowned in 33 percent of Yahoo! leagues at the moment, so he'll be the priority add for many of you.

Let's just keep a good thought for Jackson and his LCL, hoping the injury news gets no worse. No other CL issues, please.

Other popular content on the Yahoo! network:

• Blown call or not, Orioles refuse to give ground

• Tulane safety Devon Walker stops breathing after hard hit, has to be revived by CPR

• Sacramento State kicker upsets Colorado at final gun, is awarded scholarship

• Yahoo! News: Larry Flynt offering $1 million for Romney's financial records