Get breaking news alerts and special reports. The news and stories that matter, delivered weekday mornings.

Health experts say it's no surprise that New Orleans is the center of the coronavirus crisis in hard-hit Louisiana after over a million people flocked to the city to celebrate Carnival for more than a month, culminating in Mardi Gras at the end of February.

Gov. John Bel Edwards requested a Major Disaster Declaration for the state Tuesday as the number of cases rose to 1,388 in 43 of Louisiana's 64 parishes, according to the state's Health Department.

At least 46 people have died.

"It is still impossible to know exactly how long the COVID-19 pandemic will impact Louisiana, but what we do know is that we have more cases per capita than every state, except for New York and Washington," Edwards said Tuesday. On Sunday, he issued a stay-at-home order to slow the rapid rise of cases.

Full coverage of the coronavirus outbreak

While some parishes appear to be unaffected, Edwards said testing just hadn't caught up. "We shouldn't delude ourselves. It's in every single parish," he said.

Let our news meet your inbox. The news and stories that matters, delivered weekday mornings. This site is protected by recaptcha

But New Orleans, with 567 of the state's cases — 20 that led to death — is by far the center of the pandemic in the state. At least nine of the people who died resided at Lambeth House, a New Orleans retirement home and nursing facility.

Doctors and residents think Carnival, which ran from Jan. 6 to Fat Tuesday on Feb. 25 this year and draws about 1.4 million revelers from around the world, could have contributed to the outbreak in New Orleans and all of Louisiana's parishes.

#NewOrleans has one of the HIGHEST #COVID19 #coronavirus infection rates in the country. It is not time to relax, it’s time to be vigilant.



Stay home now to save lives later! pic.twitter.com/gA7Gwu30ey — NOLA Ready (@nolaready) March 24, 2020

"I think it came during Mardi Gras, given the timing of it. Someone brought it here and then it starts spreading slowly," Dr. Joshua Denson, a pulmonary and critical care physician at Tulane Medical Center in New Orleans, told NBC News.

"I diagnosed the second case, the first critically ill patient, here last weekend," he said. "Her timing was about two weeks post-Mardi Gras."

The incubation period for the coronavirus, the time between when a person contracts the virus and starts to show symptoms, is two to 14 days, according to the Centers for Disease Control and Prevention.

"This is a very important point for the American public — what we're seeing in the hospitals now are people who most likely got exposed and sick more than two weeks ago, so you're seeing what was occurring two and three weeks ago," Dr. Deborah Birx, the White House's coronavirus response coordinator, echoed on NBC's "TODAY" show Tuesday.

Dr. Richard Oberhelman, chairman of the Department of Global Community Health and Behavioral Sciences at Tulane University's School of Public Health and Tropical Medicine, also thinks Carnival crowds provided a perfect breeding ground for the highly contagious coronavirus to spread.

Download the NBC News app for full coverage and alerts about the coronavirus outbreak

"People are really packed close together, especially for some of the big parades in the downtown section and really all along the route. There are a lot of opportunities for close contact and transmission," Oberhelman said.

Most parades attract thousands of people and run routes that are about five miles long.

Bourbon Street during Mardi Gras festivities in New Orleans on Feb. 25, 2020. Rusty Costanza / AP file

"During Mardi Gras, people were not thinking about social distancing or hand-washing," Oberhelman added.

Evangeline Turner, a New Orleans bartender, said many Bourbon Street hospitality workers are also speculating that the Carnival parades and festivals contributed to the high number of coronavirus cases.

"There's no way that can't be a reason," she said.

Now, bars and restaurants are closed, and the city's next massive party, the New Orleans Jazz and Heritage Festival, has been postponed. Mayor LaToya Cantrell even ordered basketball hoops removed from city facilities Sunday because people were still out on the courts.

"I don't know how you can guard a man with social distancing," she said. "It doesn't work."