But those circumstances also prompted outrage from his many accusers, who saw him as again eluding justice, years after escaping federal prosecution on similar charges of sexually abusing girls. He was allowed to plead guilty in 2008 to state prostitution charges in Florida, and served a 13-month sentence, spending most of his days on work-release.

“I never wanted him to die. I just wanted him to be held accountable for his actions,” said Michelle S. Licata, 31, who was among the dozens of girls who Palm Beach police and the F.B.I. found were recruited to give Mr. Epstein erotic massages, which included his touching her breasts while he masturbated.

Still, many of his accusers can pursue civil claims against his vast estate, which is said to be worth more than $500 million, lawyers for some of his accusers have said.

Mr. Berman, the United States attorney for the Southern District of New York, appeared to have the frustration of Mr. Epstein’s accusers in mind when he spoke on Saturday.

“To those brave young women who have already come forward and to the many others who have yet to do so,” Mr. Berman said in a statement, “let me reiterate that we remain committed to standing for you, and our investigation of the conduct charged in the indictment — which included a conspiracy count — remains ongoing.”

It is unclear whether others will be charged; but even before Mr. Epstein’s death, it was apparent that the investigation was expanding into his finances, with F.BI. agents and prosecutors gathering evidence from banks and others.

In addition to possible sex-trafficking conspiracy charges against others, prosecutors could also seek charges of aiding and abetting Mr. Epstein or money laundering, which could lead to trials and criminal forfeiture actions. The government could try to seize assets that could be sold and used to compensate his accusers .