A Wisconsin ironworker and supporter of Sen. Bernie Sanders Bernie SandersSirota reacts to report of harassment, doxing by Harris supporters Republicans not immune to the malady that hobbled Democrats The Hill's Morning Report - Sponsored by Facebook - Republicans lawmakers rebuke Trump on election MORE (I-Vt.), Randy Bryce, has announced his run for Congress to unseat House Speaker Paul Ryan Paul Davis RyanKenosha will be a good bellwether in 2020 At indoor rally, Pence says election runs through Wisconsin Juan Williams: Breaking down the debates MORE (R-Wis.) in a campaign ad that quickly drew attention on Twitter.

The video, titled "Randy Bryce for Congress Campaign Announcement," focuses on Ryan's support for repealing and replacing ObamaCare and Bryce's mother's struggle with a chronic illness.

The ad opens with President Trump and Ryan celebrating the House's passage of the American Health Care Act, with Ryan saying "everybody doesn't get what they want."

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The ad then features an interview with Bryce's mother, who talks about the high cost of her life-saving drugs, and Bryce's admittance that many Americans couldn't afford to pay those costs.

"I'm on 20 drugs," Bryce's mother says in the ad. "And, if I don't take the one that costs them thousands of dollars, I don't know what would happen."

Bryce's messages about lowering drug costs resonated with Twitter users, including comedian Chelsea Handler, who endorsed Bryce and retweeted the ad.

This is a great ad. Randy Bryce for Congress https://t.co/Hjo9GXp4KJ — Chelsea Handler (@chelseahandler) June 20, 2017

I don't know how much of a chance Randy Bryce has against Paul Ryan in WI-1, but this is an amazing ad. https://t.co/4fUTfrE04j — Michael Li (@mcpli) June 20, 2017

Bryce ends the ad by inviting Ryan to "trade places" with him.

"I think it's time," Bryce says. "Let's trade places, Paul Ryan — you can come work the iron, and I'll go to D.C. We can do so much better together, as a community."

Ousting the House Speaker would be a significant challenge for Bryce. Ryan is popular in his district, winning it with 65 percent of the vote in 2016.

In addition, President Trump won the district over Hillary Clinton Hillary Diane Rodham ClintonBloomberg rolls out M ad buy to boost Biden in Florida Hillicon Valley: Productivity, fatigue, cybersecurity emerge as top concerns amid pandemic | Facebook critics launch alternative oversight board | Google to temporarily bar election ads after polls close Trump pledges to make Juneteenth a federal holiday, designate KKK a terrorist group in pitch to Black voters MORE by 10 points. To face Ryan, Bryce will first have to defeat David Yankovich, another Sanders supporter, in the Democratic primary.