GREEN BAY – Uncommon opponents are always a challenge, and the 2018 Buffalo Bills are about as uncommon as it gets for the Packers.

Head Coach Mike McCarthy pointed out on Wednesday that not only have the Packers not played the Bills for four years – the standard rotation of NFC-AFC matchups – but also the Bills have only two players still on the team from the 2014 meeting.

The Packers still have roughly 20 percent of their team compared to four years ago.

"We don't know them, they don't know us," McCarthy said prior to Wednesday's practice. "It's important to get in tune with the uncommon matchups we're going to be involved in. That'll be the biggest challenge through the week and come Sunday.

"But at the end of the day, we're going to spend more time on ourselves. We have a number of things to improve on and get ready for."

One of those is Buffalo's defensive pass rush. On onslaught of pressure on Minnesota QB Kirk Cousins led to turnovers and helped stake the Bills to a big early lead last Sunday in Minneapolis that led to a 27-6 victory almost no one saw coming.

Buffalo had been 0-2, but as rookie QB Josh Allen continues to settle in, the Bills are expecting to look more and more like the team that broke the franchise's long playoff drought a season ago.