The Prime Minister of New Zealand’s former cat Paddles had her own Twitter profile because the joke was her polydactyl thumbs were so big, she could write tweets.

President Theodore Roosevelt’s extra-toed cat Slippers was also reportedly quite beloved and spoiled when it lived in the White House in the early 1900s. It was believed to have had 24 toes and was allowed to attend formal dinners and sleep anywhere it liked, even in the middles of corridors.

But perhaps the most well-known polydactyl cats, aside from Lil Bub, are those living at Ernest Hemingway’s former house-turned-museum in Key West, Florida.

The author was a fan of felines with the peculiar condition, and was given his first six-toed one by a sea captain named Stanley Dexter in the 1930s. He named her Snow White and she went on to birth generations of polydactyl cats that still live on the Hemingway property today.

There are now as many as 50 of her progeny there, according to the Ernest Hemingway Home & Museum, along with a bevy of signs begging visitors “not to pick up the cats.” Only about half of the feline population exhibits extra toes, yet all of them still carry the polydactyl gene, so even those with normal amounts of toes can produce polydactyl kittens.

It also turns out that some of Hemingway’s cats have migrated beyond the confines of their small island home to elsewhere in the United States.

The researchers studying Lil Bub’s blood discovered, to their surprise, that the 8-year-old social media darling was actually a descendent of the author’s tribe of six-toed cats.

Even though she was born feral and discovered in a tool shed in rural Indiana, Lil Bub shared the same gene mutation that those living more than 1,000 miles away from her also possess.