A Melbourne woman's worst nightmare came to life on Sunday, when a snake wound itself around her car's windscreen wipers, as she was driving through the city.

Toni O'Sullivan was driving back to her CBD home after grocery shopping in Albert Park, when a python appeared on the glass in front of her.

But she didn't notice the snake until she was almost home.

On Sunday afternoon she parked her Volvo Coupe under some trees on Bridport Street and went into the shops for "about 20 minutes".