NEW DELHI — Gulalai Ismail is one of Pakistan’s best-known women’s rights crusaders, speaking out about forced marriages, gang rapes and crushed dreams.

Her groundbreaking work has carried her around the world, winning her awards and audiences with high-powered women such as Michelle Obama and Queen Elizabeth II.

But in her own country, Ms. Ismail has become an enemy of the state, accused of inciting rebellion. And now she is on the run.

For two months, practically no one has seen her. Pakistan’s security services, known as among this region’s most cunning and brutal, can’t find her. They have raided her house several times and deployed scores of officers, and, according to Ms. Ismail’s family, abducted and tortured family friends to extract information.