He'll lose his first game in Week 4 against the Los Angeles Chargers , ending his perfect starting record at 10-0. The 49ers are set up for success with Jimmy Garoppolo as their franchise quarterback. They have built the team around him, and I think he gets off to a fast start with a full offseason in San Francisco. However, the Chargers could be the team to give him his first loss, because they have the offense to score a ton of points, and the defense should be one of the best in the league.

If you're wondering why I think the 49ers will win in Minnesota, I'll keep it real simple. There's a ton of pressure on Kirk Cousins to win, and that pressure to win and perform at home could be overwhelming. The 49ers go up to Minnesota with nothing to lose, and they'll be able to take advantage of a very tight, intense Vikings team, because they will be able to play free and loose. I don't see San Francisco going home from Minnesota in Week 1 with a win. Unfortunately for the 49ers, the Vikings boast the best defense from 2017, and defenses are normally 17 steps ahead of offenses anyway at the start of the season. Sorry, Jimmy. I know Week 1 will be a popular choice, because the 49ers will play a formidable defense in the Minnesota Vikings. Because it's not like he didn't beat the Jacksonville Jaguars last year! I have no fear Jimmy G will fall to the Vikings. They win a laugher over the Lions. So his first NFL stumble will come against Andy Reid and the Chiefs in Week 3. I mean, the Vikings are tough, but Reid is basically Vince Lombardi in the first month of the season. Well, Jimmy, you had a good run. The run as an undefeated starter (the 49ers even won the pre-draft coin flip against the Raiders!) isn't likely to last through Week 1 when San Francisco heads to Minneapolis to face the Vikings. The Niners have the makings of an improved team, but taking on a Super Bowl contender trying to erase the unpleasant taste of last year's NFC Championship Game loss isn't going to be easy. The winning streak is over for Jimmy G before the season even really starts, as he'll suffer his first loss in Week 1 in Minnesota. Jimmy G and the 49ers won't get by a Minnesota defense that ranked No. 1 overall and second against both the run and pass. Playing against Mike Zimmer's defense in U.S. Bank Stadium ... need I say more?