2x01 Parallax: Season 2 begins with Masters dealing with the ramifications of his disastrous presentation and being fired from the hospital. Meanwhile, Libby urges Masters to get another job; and Virginia fights off advances and innuendos stemming from the belief that she was the woman in Masters’ explicit film.

2x02 Kyrie Eleison: Masters begins a new job at Memorial Hospital under Betty’s extortion terms only to discover that his boss insists he leave Virginia behind in favor of a handpicked secretary. Meanwhile, Johnson is torn between pressing Masters to rehire her and staying by DePaul’s side as her condition worsens.

2x03 Fight: Virginia learns about Masters’ troubled childhood when they meet at a hotel for a secret rendezvous.

2x04 Dirty Jobs: Johnson tries to cover when she and Masters are seen by Langham leaving a hotel together after an evening tryst. Later, Masters attempts to bring Johnson aboard as his assistant at his new post; and Betty tries to conceal her infertility from Gene, over Masters’ objections.

2x05 Giants: Masters breaks new ground by continuing his study as the only white physician in a black hospital but at the cost of his gynecology practice. Meanwhile, Libby is confronted by Robert over her poor treatment of his sister; Betty reunites with her former lover; and Johnson struggles to right her relationship with DePaul, who is now aware of her ongoing affair with Masters.

2x06 Blackbird: Hendricks bans Masters from using black participants in his study, but Masters contacts a journalist to aid his efforts. Meanwhile, Johnson is forced to accept DePaul’s choice to end her chemotherapy treatments; Gene learns the truth about Betty and Helen’s relationship; and Libby fires Coral after discovering she lied about Robert being her lover.

2x07 Asterion: Masters becomes impotent without Johnson’s knowledge, after learning that she is continuing to have romantic relationships with other men, so he cuts off their sexual work together. Meanwhile, Masters tries to keep his new clinic solvent by borrowing against his house and offering medical services to the hotel.

2x08 Mirror, Mirror: Masters privately treats a couple for infertility; Johnson gets in over her head when she tries to treat Barbara Sanderson on her own; Libby witnesses a hate crime that is whitewashed by the police.

2x09 Story of my Life: Masters bristles at Frank’s insinuations about his and Estabrooks’ demons; Virginia uses a patient’s case history to gain advice from a psychiatrist; Betty and Masters try to remedy Lester’s impotence by hiring a prostitute; Barbara gets an unsettling diagnosis that threatens to expose a chain of secrets.

2x10 Below the Belt: Johnson tries to find a cure for Masters’ sexual difficulties; Masters learns of a rival study and tries to brand his work; Flo informs Langham that he must have sex with her in order to keep his job; Barbara and Lester connect over their shared sexual dysfunctions; Libby asks Johnson to give her an alibi while she canvases a tenement for a rent strike with CORE.

2x11 One for the Money, Two for the Show: A television crew arrives to document Masters and Johnson’s work.

2x12 The Revolution Will Not Be Televised: Season 2 ends with Masters and Johnson passing the results of their studies on to the world.