Karl Stefanovic has torn into the Daily Mail for their "sexist" and "shameful" coverage of women.

Stefanovic was speaking specifically about an article published yesterday on the website which pictured him checking into a caravan park in Yamba, NSW, with a younger female colleague.

The headline, which has since been changed, made reference to the fact Stefanovic's girlfriend was not present.

"Fact: This was work. We were filming a story about our struggling prawn farmers," he said.

"The producer pictured on the website is a committed, talented, hard-working and totally professional young woman and not deserving of this cheap, lazy, sexist online slur.

"A young woman who spent the past hours in tears because of the hurtful and false way she's been portrayed by this website."

But Stefanovic took issue not only with the content of the article, which he said also inferred he was "a drunk", but with the Daily Mail itself.

"It's a news website, one which seeks to profit from criticising and publicly humiliating people, women especially," he said.

"This site specialises in shaming women; for how they look, for what they wear, for how much they weigh, for how much weight they've lost, for going to the beach."

"It has a despicable track record of denigrating women for who they are, what they look like, the choices they make, for denigrating women full-stop."

Stefanovic then went to call out the Daily Mail's track record of criticising his colleagues.

"This is the site that ridiculed Lisa for wearing the same blouse four months apart," he said.

"The same site that tried to shame Sunrise hose Samantha Armytage for wearing so-called 'granny pants'.

"Go hard on me, make up your stories, publish your lies, send out your paps, but if you have sliver of decency, if you have any care whatsoever for the women of Australia, do not slur the reputations of others in your eagerness to throw mud at me.

"And if you agree with me, the best thing you can do is never go to that website."

Co-host Lisa Wilkinson offered her support to Stefanovic and called on viewers to let them know what they think.