A 15-year-old from Hamilton, a Toronto man and a Mississauga man have all been charged with first degree murder in connection with the death of Toronto man Nathan Miller.

Miller was shot and killed in central Hamilton back in January, and was Hamilton's first homicide of 2015.

Tactical officers and members of the vice and drugs and gangs units made two arrests connected with the case in central Hamilton Wednesday afternoon, police say.

It was there that officers confronted a 21-year-old Mississauga man and a 15-year-old from Hamilton. The Mississauga man tried to run, but was arrested after a struggle, police say.

The officers searched the two men, and found a loaded .32-calibre gun on the 22-year-old, and a loaded .357-calibre gun on the teen. No shots were fired during the arrests, Det. Sgt. Joe Stewart told CBC News.

The 15-year-old was also carrying cocaine and marijuana, police say. Stewart said it is "absolutely rare" for Hamilton police to charge a 15 year old with first degree murder.

He added that police are confident that this was a "targeted incident," but there is no evidence that it is gang related.

A third man – a 20-year-old from Toronto – is currently in custody on an unrelated charge and will be brought before a court to be charged in connection with Miller's death. The man was actually arrested on the other charge by police in Hamilton back in April, and was handed over to Toronto police.

Police are still searching for two other men in connection with the case. Stewart said he doesn't believe there is a danger to public safety, "But having said that, you have to keep in mind that they were involved in a very violent homicide," he said.

The first man is described as a 20-year-old black man, about 6 foot 5 inches tall and with a medium build wearing a Crooks and Castle jacket.

The second man is described as a black man with lighter skin, about 6 foot 5 inches tall and with a medium build. Police say one of the two men is described as having acne and/or a skin pigmentation disorder on his face.

Earlier this year, police reported that five men were allowed into a house at 28 Madison Avenue. Once inside, Miller was shot multiple times and died, police say.

Neighbours say the home had frequent visitors, fights and late night arguments.

At the time, neighbour Aaron Spafford said an incident "was bound to happen, it was a f------ crack house."

adam.carter@cbc.ca | @AdamCarterCBC