The MPEG-G standard jointly developed by MPEG and ISO Technical Committee for biotechnology standards (ISO TC 276/WG 5) is the first international standard to address and solve the problem of efficient and cost-effective handling of genomic data by providing, not only new compression and transport technologies, but also a family of standard specifications associating relevant information in the form of metadata and a rich set of Application Programming Interfaces (APIs) for building a full ecosystem of interoperable applications and services capable of efficiently processing sequencing data.