On ABC Family's new series Pretty Little Liars (premiering June 8), based on the young-adult mystery novels, Lowe appears as a professor who had an affair with a student. He's not the only one with secrets. The show follows a teen queen's disappearance — and the revealing messages she still seems to be sending to her BFFs, including the professor's daughter, Aria. ''I may, at 42, not quite be the target audience for this show,'' says Lowe (pictured with Holly Marie Combs, who plays his wife). ''But it's a complicated, adult story that's relatable and a lot of fun to portray.'' —Jennifer Armstrong