The San Francisco 49ers 2020 opponents have been set. Dates and times of the 2020 schedule have yet to be determined, however the 49ers know which teams they will face next season. The official NFL schedule for the upcoming season is likely to be released this coming April.

San Francisco heads into the regular season with the fourth-toughest strength of schedule based on their opponents 2019 win percentages (.527). Only the Miami Dolphins (.529), New York Jets (.533) and New England Patriots (.537) have tougher upcoming schedules. The 49ers are scheduled to play six teams coming off of playoff appearances in 2019.

In addition to San Francisco's divisional opponents (Arizona Cardinals, Los Angeles Rams and Seattle Seahawks), the 49ers will also face the NFC East and AFC East. The 49ers will also see the New Orleans Saints and Green Bay Packers, as both teams also finished first in their respective divisions.