Perth will lose one of its landmark buildings when the mothballed Entertainment Centre is levelled as part of one of the city's largest developments.

The Perth Entertainment Centre, whose future had been under a cloud after the Perth City Link project got the go-ahead last year, will be demolished next year.

The Perth Entertainment Centre, once WA's premier concert venue, is destined for demolition. Credit:Joseph Sapienza

It will make way for a Seven Network-backed mixed-use development, as well as bus and rail infrastructure works, as part of the Link project.

Seven owns the "EntCent", which has been vacant since 2002.