In the United States, many legislators and public health officials are busy trying to make vaccines de facto compulsory—either by removing parental/personal choice given by existing vaccine exemptions or by imposing undue quarantines and fines on those who do not comply with the Centers for Disease Control and Prevention’s (CDC’s) vaccine edicts. Here, Kristina Kristen compares vaccine policy and subsequent outcomes in the US and Japan. The differences are startling.