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Luton Town made Manchester United work for its spot in the League Cup fourth round, while another lower league side simply ended another Premier League side’s tournament in Tuesday’s FA Cup results.

[ MORE: Mendy to Chelsea analysis ]

West Bromwich Albion is out of the tournament after blowing two leads and losing in penalties at home to Brentford, while West Ham blasted Hull City after an alarming COVID-19 moment and League Two side Newport County dismissed Watford.

Then there’s Tottenham and Leyton Orient, who didn’t even get to play. It’s all in the FA Cup wrap.

Luton Town 0-3 Manchester United

The score line does not tell the story here (aside from, you know, the goal total).

Brandon Williams won a late first-half penalty that Juan Mata smashed home as the Red Devils labored to a win over the Championship’s Hatters.

Marcus Rashford came off the bench to ice the game off a feed from fellow sub Mason Greenwood, who was later assisted by another sub in Bruno Fernandes.

Dean Henderson made an outstanding save in his long-awaited Manchester United senior debut.

The 23-year-old has been United property since he was 14 and has taken loans with four clubs including a highly-celebrated two years with Sheffield United.

Henderson did not have to make a save until the 81st minute, when he made a big stop to keep United on top at Kenilworth Road.

Mata’s goal came in his 200th appearance for the Red Devils. Donny van de Beek made his first Manchester United start in the win.

23 & 19 – Since the start of last season, Manchester United have both taken (23) and scored (19) more penalties in all competitions than any other English league side. Inevitable. #CarabaoCup — OptaJoe (@OptaJoe) September 22, 2020

West Ham United 5-1 Hull City

Andriy Yarmolenko scored twice and set up two others as the Irons showed no ill effects of learning that David Moyes, Issa Diop, and Josh Cullen tested positive for coronavirus (The club says all three are asymptomatic).

Yarmolenko now has nine goals and five assists in just over 1700 minutes with West Ham. He missed 2.5 months with a muscle tear last season.

Sebastien Haller had a brace and Robert Snodgrass scored the other goal as West Ham’s “second string” continues to beat up on lower league competition while awaiting chances off the bench in the PL.

Mallik Wilks had brought Hull within two in the 70th minute only to see Haller and Yarmolenko complete their braces in stoppage time.

Newport County 3-1 Watford

The Hornets had little going for them despite having the better of possession, outshot 12-2 by the time League Two’s Exiles reclaimed their two-goal lead with 25 minutes on the clock.

Adelberto Penaranda came off the bench to score for Watford after the Exiles built a 2-0 lead through Tristan Abrahams and Josh Labadie. Padraig Amond bagged County’s third goal to turn the screws on the former Premier League side.

Stipe Perica sealed Watford’s fate with an 88th-minute red card. The Hornets have a win and a draw in their return to the Championship and will focus on that until the FA Cup.

West Bromwich Albion 2-2 (4-5 pens) Brentford

The Bees couldn’t catch the Baggies in the race for the automatic promotion last season but kept scrapping en route to a pair of equalizers at the Hawthorns on Tuesday.

Brentford made all of its penalties, its fifth sealing the win after Grady Diangana’s effort was saved by David Raya.

Hal Robson-Kanu scored both of West Brom’s goals but answers came from Emiliano Marcondes and Marcus Forss to have it level with 17 minutes left in scheduled time.

Leyton Orient (ppd) Tottenham Hotspur

A raft of positive COVID-19 tests for the hosts put this tie in doubt Monday and we’re still awaiting the plan.

For now, health aside, Spurs are probably quite happy to have day off given a wild fixture list across three competitions which includes a trip to Macedonia for Europa League action on Thursday.

Next League Cup third round fixtures

All times ET

Wednesday

Preston North End v Brighton — 2 pm

Millwall v Burnley — 2 pm

Fulham v Sheffield Wednesday — 2 pm

Stoke City v Gillingham — 2 pm

Chelsea v Barnsley — 2:45 pm

Leicester City v Arsenal — 2:45 pm

Fleetwood Town v Everton — 2:45 pm

Morecambe v Newcastle United — 2:45 pm

Thursday

Bristol City v Aston Villa — 2 pm

Lincoln City v Liverpool — 2:45 pm

Manchester City v Bournemouth — 2:45 pm

League Cup fourth round draw

Lincoln City/Liverpool v Leicester City/Arsenal

Millwall/Burnley v Manchester City/Bournemouth

Brentford v Fulham/Sheffield Wednesday

Fleetwood Town/Everton v West Ham United

Bristol City/Aston Villa v Stoke City/Gillingham

Leyton Orient/Tottenham v Chelsea/Barnsley

Newport County v Morecambe/Newcastle United

Preston North End/Brighton v Manchester United

Follow @NicholasMendola