Does that mean Daniel Jones and the Giants (2-3) have no chance? Well, probably.

It does not help that the Giants will be without Saquon Barkley (ankle), Wayne Gallman (concussion), Evan Engram (knee) and Sterling Shepard (concussion), leaving them remarkably short-handed against the N.F.L.’s top-rated defense in yards allowed (238.4), points allowed (6.8) and interceptions (11).

The Giants happen to have a veteran quarterback on their bench who knows a thing or two about beating the Patriots in big games, but letting Jones — who has been far less sharp in his second and third starts than he was in his first — get an up-close look at the best the N.F.L. has to offer will probably be a good thing in the long run, provided his confidence can survive. Pick: Patriots -17