Three high-ranking officers at the center of J.P. Morgan Chase & Co.'s giant trading blunder are expected to leave the firm this week, said people familiar with the situation, and losses on the trade have grown.

Expected to leave as soon as Monday are Ina Drew, who has run the risk-management group tied to the losses since 2005; Achilles Macris, who was in charge of the London-based operation that placed the questionable trades; and trader Javier Martin-Artajo.

As...