Photo: Greg Baker/AFP/Getty Images

This is the fourth article in a special series focused on health related issues. The previous pieces in this series can be read here, here and here.

In the mid-1990s, when I switched fields from computer science to biology, one of the main reasons I did so was the profound lack of respect that biogerontology endured within biology generally. My then wife, a highly accomplished geneticist, exemplified this view: When asked why she wasn’t interested in the biology of aging, she simply said that it was a “descriptive” field, which is a standard euphemism for a field that is too immature to allow for the alternation between hypothesis formation and hypothesis testing that is the hallmark of “real science.” In fact, many would go further and dismiss biogerontology as a haven of mediocrity. And, to be brutally honest, when I entered the field, it was only in the early stages of becoming—and becoming viewed as—something more than that.

Nowhere is the problem of aging as pronounced as it is in Asia. It is estimated that in the next 15 years, $20 trillion will be needed just to support rapidly aging populations in Asian economies. In fact, by 2030, the number of elderly people in Asia will increase by 200 million. That represents a 71 percent increase in Asia’s elderly population, compared to 55 percent in North America and 31 percent in Europe.

The relevance of biogerontology can never be understated in the context of aging societies in Asia.

Biogerontology Today

Twenty years is a long time in science, and today we are at the gratifying point where the biology of aging is generally viewed as having risen to its rightful place in the pantheon of scientific disciplines. In particular, it is no longer merely a basic science: It has become a truly translational field, in which our understanding of aging’s mechanisms has given rise to the rational design of approaches to mitigate, or even eliminate, aging’s effects on the health of the elderly.

The basis of these approaches is the recognition that, just like simple machines, the complex machine called the human body inflicts damage upon itself as an inevitable consequence of its normal operation, and that it can tolerate only so much such damage before declining and eventually failing entirely in function. This leads to the realization that the way to transcend the body’s “warranty period” is, again, just as for simple machines, to do periodic, comprehensive, preventative maintenance. This will eliminate some of that damage every so often, so that it never exceeds the tolerable threshold, even though it is continuing to be created.

That’s easier said than done, of course, because the human body is so much more complicated than any machine made by humans (and besides, we don’t have its design plans). But in practice, the complexity is not as daunting as it may initially seem. It turns out that the many types of damage that we need to eliminate fall into just seven major categories, each of them amenable to a generic strategy for repair. For example, one category is cell loss: cells dying and not being automatically replaced by cell division. This happens in many parts of the body with age. The generic fix is stem cell therapy—replacing those cells by injecting precursors that divide and differentiate into the needed replacements. Different tissues need different stem cell therapies, but the commonalities between all stem cell therapies mean that once we have a few of them working, it becomes much easier and quicker to get the next one working.

Exhibit: The Seven Types of Aging Damage and Their Maintenance Approach