The wife of a man dying of cancer faces a desperate race against the clock to raise £400,000 so he can receive life-saving treatment in America.

Kate Brandon, 33, has just six days to raise the money so her husband Mike to join a new clinical trial in the US which could potentially cure him of cancer - allowing the pair to have a baby together.

Launching a campaign to raise funds, she has released a heartbreaking video begging people to share his story and donate to the cause.

Choking back tears, she says: ‘I’m sure you can all imagine what it is like being faced with losing the most important person to you.

'Please help me combat what we’re facing. I know with your help we can get him to where he needs to be.

'We can't go down without a fight. You hear of miracles all the time, they are rare but they happen.'

As of this morning, the total raised stands at more than £150,000 after donations poured in from around the world overnight - at one point crashing the site.

Kate Brandon has just six days to raise £400,000 so her husband Mike, 31, can receive life-saving cancer treatment in America

Mr Brandon was diagnosed with acute lymphoblastic leukaemia in 2014 and underwent chemotherapy and a stem cell transplant. But the disease returned and NHS doctors said there is little they can do to save him

Mr Brandon, 31, was dealt the devastating blow he had acute lymphoblastic leukaemia - cancer of the blood - in January 2014.

A campaign to find him a stem cell donor went viral and the life-prolonging treatment allowed the couple to achieve their dream of getting married.

But just two years later they received the devastating news the cruel disease had returned - this time more aggressive than ever.

Now Mr Brandon's only hope is to travel to Pennsylvania for specialist therapy - at a cost of £400,000.

Despite this, his wife is determined to raise the money to save his life.

Mr Brandon was diagnosed unexpectedly two years ago after experiencing night sweats and fatigue.

He immediately began chemotherapy and doctors said his condition was so severe that he only had until the start of July that year to find a donor.

Mrs Brandon, then Miss Robertson - who was backpacking in Asia when she received the news - described the revelation as the ‘the worst day of her life’.

‘I was completely shocked when he told me. My only plan was to get home,' she said.

Mr Brandon was initially told that there was a 60 per cent chance one of his three brothers would provide a positive match and could donate stem cells.

When none were deemed suitable, the couple contacted Anthony Nolan, a charity which saves the lives of people with blood cancer who need a stem cell (or bone marrow) transplant.

Within days, their race against time had hit the internet where it grabbed attention across the world.

The diagnosis came unexpectedly two years ago after Mr Brandon experienced night sweats and fatigue

A campaign to find him a stem cell donor went viral and the life-prolonging treatment allowed the couple to achieve their dream of getting married

But just two years later they received the devastating news the cruel disease had returned - this time more aggressive than ever. Now Mr Brandon's only hope is to travel to Pennsylvania for specialist therapy - at a cost of £400,000

Mrs Brandon started a campaign called #Shake4Mike in which she asked the public to register with the charity as stem cell donors and upload 'shaky face' selfies to social media before nominating a friend to do the same.

The campaign went viral and was backed by UK and international press, reaching more than 200 million people worldwide - leading to thousands more donors registering.

In May, the couple were ecstatic when the search yielded a donor - and on 30th June 2014, his 30th birthday, Mr Brandon got his lifesaving transplant.

Since then, he has been taking anti-cancer drugs and undergone more than 20 gruelling bone marrow biopsies.

He also contracted pneumonia and needed five further infusions of stem cells and white blood cells from his donor.

The couple are desperate to become parents and say other cancer drugs may not sufficiently prolong Mr Brandon's life

But despite the setbacks, the couple were able to enjoy the wedding of their dreams in June 2015.

'Seven days before the wedding Mike was really sick and I didn't think it would go ahead,' Mrs Brandon said.

'I can't believe how well he was on the day. He lasted from beginning to end and even got up and danced which I never thought he'd have the strength to do.

'My favourite part was the ceremony, our hands remained tightly clasped together throughout - to finally get to that day was such an achievement.

'I felt so happy the entire time. I loved it all and wouldn't have changed a thing.'

Afterwards, Mr Brandon went back to work, playing golf and visiting family - and it felt as though the newlyweds were beginning a life together that resembled normality.

But their joy was to be short lived, as in February 2016 he began to feel ill again.

Tests revealed his white blood cells had plummeted and doctors were forced to investigate pains in his chest.

A month later, in late March, the couple received devastating news that his leukaemia returned - this time more aggressive than ever.

In previous relapses, Mr Brandon's levels of leukaemia were 0.1 per cent or less - this time doctors warned they had soared up to 48 per cent.

His physician, Professor David Marks, based in the Bristol Haematology and Oncology Centre, was forced to told the couple there was little he could do to save his life.

With her husband having undergone every treatment the NHS offers, Mrs Brandon searched for a solution - and discovered a treatment called CAR T-Cell therapy.

This is where stem cells are inserted into the body - and prompt the immune system to fight the cancer.

'After the first year of marriage we should be planning a family, not a funeral ,' Mrs Brandon, 33, said

Travelling to Pennsylvania really is Mr Brandon's last of survival, the devastated couple believe

But British doctors warned Mrs Brandon the treatment - including the cost of medical care and relocation to the US - could easily reach £1 million.

Instead, Mr Brandon was started on a new drug called Inotuzumab - not yet licensed in the UK.

A trial of the drug found that 79 per cent of patients who took it went into remission.

But they all eventually relapsed – on average after just 4.8 months.

For the Brandons, this is not long enough - as they are desperate to become parents.

'Inotuzumab gives us hope because we've been told it provides a good chance of complete remission - but the average time is only four months,' Mrs Brandon explained.

'It's not long enough. I want to have a baby.

WHAT IS ACUTE LYMPHOBLASTIC LEUKAEMIA? Leukaemia is cancer of the white blood cells. Acute leukaemia is that which progresses rapidly and aggressively. Lymphoblastic leukaemia is cancer of the lymphocytes - the white blood cells that fight viral infections. Symptoms of acute lymphoblastic leukaemia include pale skin, tiredness, breathlessness and repeated infections. It affects about 650 people a year in the UK and is the most common type of cancer in children. Approximately one in every 2,000 children will develop it. About 85 per cent of cases occur in children under the age of 15. Treatment usually involves a combination of chemotherapy and radiotherapy and a stem cell transplant is sometimes required. Source: NHS Choices Advertisement

'That's what people should be doing after their first year of marriage. They should be planning their family, not planning a funeral.'

To make matters worse, Mr Brandon did not responded as positively to the drug as Professor Marks would have liked.

This means travelling to Pennsylvania really is his last chance of survival.

The University of Pennsylvania's Abramson Cancer Centre, which is conducting the trial, will cover the cost of the drugs they are assessing.

It has also granted the couple $16,000 (around £11,900) to assist with travel and living costs.

However, they must pay £400,000 to cover the cost of all other medical care and secure one of the six remaining places on the trial.

'The drug buys us some time but Professor Mars says it won't get him to complete remission,' Mrs Brandon said.

'CAR T-cell therapy, on the other hand, has really high response rates of complete remission.

'To me it seems like more of a cure. Mike has so much love and strength we have to exhaust all options.

'Our last campaign reached 200 million people - we just need a fraction of those to donate money.'

'It's not Shake4Mike anymore; it's DONATE4Mike.

'We need £400,000 to give us hope again, and we need it as quickly as possible.'

Since beginning the campaign she said she has been filled with energy and positivity - and is determined that achieving her goal is possible.

She said: 'There are times when Mike and I have thought maybe we should just relax now and let go, but you simply have to know that you have tried everything.'

To donate to Mr Brandon, visit: https://www.gofundme.com/donate4mike