Bob Bryan and Mike Bryan reached the Internazionali BNL d'Italia quarter-finals for the 15th time on a manic Thursday in Italy, defeating Russian Karen Khachanov and Spaniard Marc Lopez 6-3, 3-6, 10-3 in 68 minutes. The four-time champions are pursuing their second ATP Masters 1000 trophy since Bob returned at the start of the year from a hip surgery.

The Bryan Brothers made all seven of their first serves in the Match Tie-break and won each of those points to move into the last eight. This year's Miami and Delray Beach titlists will play third seeds Juan Sebastian Cabal and Robert Farah in the quarter-finals, as the Colombians defeated American Austin Krajicek and Kiwi Artem Sitak 6-3, 6-2 in 64 minutes.

Top seeds Lukasz Kubot and Marcelo Melo advanced to their sixth consecutive quarter-final with a 7-5, 6-3 victory against Austrians Jurgen Melzer and Dominic Thiem. The Polish-Brazilian duo is chasing its first trophy of the season. Eighth seeds Henri Kontinen/John Peers and Argentines Guido Pella/Diego Schwartzman will play for the right to face Kubot/Melo.

Brits Kyle Edmund and Neal Skupski caused the biggest upset of the day, defeating fourth seeds Nikola Mektic and Franko Skugor, the Monte-Carlo winners, 7-6(3), 1-6, 10-7. It is Edmund and Skupski's first Masters 1000 quarter-final as a team. They will face fifth seeds Oliver Marach/Mate Pavic or Denis Shapovalov/Fernando Verdasco.

Also advancing on Thursday were sixth seeds Raven Klaasen and Michael Venus, who ousted Matwe Middelkoop and Gilles Simon 6-4, 6-2 in 58 minutes. They will battle Argentines Maximo Gonzalez and Horacio Zeballos in the quarter-finals.