The most significant drawback of natural strings is the cost to make them and their quality control. They are significantly harder to make than the synthetic versions. They also suffer from very weak durability when the ball strikes the racket in off-center places which is very typical behavior for beginners. So, if you are a beginner I advise you to stay from these as the cost to durability does not benefit the average beginner.

The other big problem is the variability that comes with them. Due to them being natural they suffer from quality control between different brands and even batches of the same brand. While some players might be able to handle it I generally stay away from them because of this.

They also expire pretty fast and they have to be kept in extremely controlled conditions to maintain their longevity.