Research In Motion Ltd. said it will cut 2,000 jobs, almost 11% of its work force, the latest move in a make-or-break scramble to resuscitate its products and keep the company that essentially invented the smartphone from becoming an also-ran.

The BlackBerry maker has struggled to stanch its shrinking share of North American smartphone sales in the face of an onslaught led by Apple Inc.'s iPhone and products run on Google Inc.'s Android operating system. The company's long-time co-chiefs, Mike Lazaridis and Jim Balsillie,...