The Baird Government has made more significant changes to its planned WestConnex tollway which create winners in Camperdown and losers in Newtown and surrounds, according to stakeholders.

The changes apply to the $7-billion M4-M5 link from interchanges at St Peters to right Rozelle, where the twin tunnels connecting the two motorways will be widened from three lanes to four in both directions.

Access ramps and a ventilation stack at Camperdown have been scrapped — removing the impact of the road on Royal Prince Alfred Hospital.

More WestConnex changes

NSW Roads Minister Duncan Gay said the tunnels could now open a year earlier in 2022, with construction and design to begin "almost immediately".

Mr Gay said widening the tunnels would "future-proof" WestConnex.

"Everyone in Sydney remembers Labor's folly on the M5 East that was built with two lanes and it was redundant from the time it was opened," he said.

"In this case we've carefully gone back to the drawing board and made the changes."

Mr Gay said the changes would not cost any more and mean property acquisitions would be kept to a handful of commercial buildings.

The tunnels' alignment has also been moved about a half a kilometre to the West.

The removal of the Camperdown ramps means people travelling to and from Sydney's east will now have only two options to join or leave the tollway — the interchanges at Rozelle and St Peters.

Plenty of opposition

Greens MP Jenny Leong believes the changes will feed even more traffic into St Peters which is part of her state seat of Newtown.

"It requires a reassessment of the environmental impact statement around the St Peters interchange because traffic conditions will be significantly changed," Ms Leong said.

"While on one hand the bulldozers have come in, on the other hand we're seeing lines on the map being moved and changed ... it makes a complete mockery of [the] planning process."

WestConnex Action Group spokeswoman Lorrie Graham said there were even more losers from the changes with at least "1,000 historic houses from St Peters to Rozelle which are built on shale and will now be on top of an eight-lane freeway".

"Also the cancellation of the Camperdown exit will mean that more traffic will be diverted to King Street Newtown which is already a car park," Ms Graham said.

"They will have to turn it into a 24-hour clearway which will destroy the community."

Government making it up as it goes: Labor

But Ms Graham said there were some winners from the new plan.

She said the residents in Arundell Street, Glebe whose houses had been earmarked for acquisition for an exit ramp but will now be spared.

She also said Royal Prince Alfred Hospital and Sydney University would benefit from not having a tunnel beneath them.

WestConnex Action Group spokeswoman Lorrie Graham shows off a map detailing the changes. ( ABC News: David Spicer )

Glebe resident Tanya Dus agreed the "area has dodged a bullet".

"We have been saved. Just like the green bans of the 1970s."

Labor MP Jodi McKay said the Baird Government was "making it up as it goes along".

"These changes have been put in under the cover of the US election with no detailed explanation," she said.

"This project has been made up as it goes, this is not how you build infrastructure."