This Review chronicles fresh developments in colloidal quantum dot photovoltaics (QD PV) including thin-film processing and surface passivation strategies, device architectures, roll-to-roll-compatible ambient manufacturability, and long-term stability. Pathways to >20% power conversion efficiencies, including V oc improvements and tandem architectures, are discussed. It is suggested that gigawatt-scale PV production is within reach provided recent advances in artificial intelligence and machine learning are leveraged for optimization and fabrication of QDs, QD thin films, and photovoltaic panels. Ahmad R. Kirmani created the cover.