Vandals have plastered the word 'tyrant' over Queensland Premier Campbell Newman's electorate office in Brisbane.

The word has been spray-painted four times on the front windows of Mr Newman's electorate office at Ashgrove in Brisbane's inner-west.

Vandals also drew two radiation symbols.

A photograph of Mr Newman in the office window was also defaced with a 'Hitler' moustache.

The attack comes in the wake of Mr Newman's decision to lift the state's ban on uranium mining.

His staff were not aware of the incident until contacted by the ABC early this morning.

A spokeswoman for Mr Newman says the vandalism was not only destructive but illegal and the clean-up will cost taxpayers' money.

She urged anyone with information to call Crimestoppers.

Police have been notified.