Andre Schurrle, Marco Reus and Erik Durm have been ruled out for Borussia Dortmund's trip to rivals Schalke, while U.S. international Christian Pulisic is a minor doubt, BVB coach Thomas Tuchel has said.

Pulisic, 18, caught the eye with one goal and three assists as he helped United States to a 6-0 win against Honduras and a 1-1 draw with Panama. The winger was one of the last players to return to Dortmund following Tuesday's clash, and Tuchel said that could mean he potentially misses the derby.

"Christian is a very young player," Tuchel told his prematch news conference ahead of the derby at Schalke. "He played a lot for us, then did all the exhausting travelling. Add to this the deserved hype he's getting in the States, and the way the opponents play, and it has certainly left its traces."

Christian Pulisic is likely to play some role for Borussia Dortmund against Schalke. Getty Images

Tuchel added that Pulisic was rested on Thursday, but confirmed he was set to take part in the final training session ahead of the 150th competitive derby.

"Let's see how he coped with it all," he added. "We need to talk to him. But I'd like to think that he will be in the squad, and so he could either start or come off the bench."

Dortmund, who drew the reverse fixture at the Westfalenstadion 0-0, will be without long-term absentee Mario Gotze as well as Reus, who is working on his comeback following a muscle tear in early March.

Germany international Schurrle and wing-back Durm have also been ruled out for the clash, but Tuchel was confident that Dortmund can pick up three points to kick off a tough run of nine games in April.

"We travel to Schalke to win," he said. "We expect a very emotional and aggressive Schalke. We won't stand a chance if we don't adopt those virtues."