Move over, Bitcoin. There is another uncommon tender angling for a spotlight, or in this case, a comeback: the $2 bill.

Heather McCabe is on a one-woman mission to revitalize the quirky greenback through deliberate casual use.

For others like Matthew Zaklad, who pours roughly 7,000 notes into circulation each year, the goal is to create meaningful interactions in otherwise mundane encounters.

In Ms. McCabe’s 15 years as an ambassador of the deuce, she has been flatly rejected at a bowling alley on Staten Island, was told to pay with something else at a bar in the East Village and is constantly solicited by people who want to buy her bills.