Five years ago, when JoAnn’s Alzheimer’s was first diagnosed, I couldn’t imagine anything less fair. At the time, I composed a mental list of all the people I knew who could lose their minds without anybody noticing, scores of people whom I’d never heard say one original thing. While my grandmother, on the other hand, was the genius of the cocktail party, a brunette version of our fellow Texan Ann Richards, who always seemed poised with a staggering, stiletto quip.

As a young artist in New York, I’d spent years trying to find my voice. When I did, it was my grandmother’s. To this day, I’ve never liked anything I’ve created that didn’t somehow remind me of her. So the fact that my clumsy development and slow self-discovery was occurring just as her decline began felt like a tragic bargain. I was finding my voice just as she was losing hers.

The only certainty about Alzheimer’s is that it’s characterized by uncertainty: There is no definitive test, no definitive diagnosis. But in July several years ago, after undergoing a gruesome but unserious operation, my grandmother began to exhibit signs of the disease. It was as if her anesthesia never lifted.

I now believe she suffered a mini-stroke mid-operation  an event that frequently “ignites” incipient Alzheimer’s  but by the time I formed this suspicion, it was too late to test. So throughout that year, as my grandfather and I accompanied her to a legion of new doctors, each of whom mentioned the possibility of Alzheimer’s, my grandmother grew ever more foggy, sometimes hilariously so.

“The wonderful thing about Alzheimer’s,” she would say, unfurling her arm like Bette Davis, “is that you always live in the moment.”

Like many Southern women of her generation, my grandmother had been a stifled lady prone to fits of drape-drawn depression, medicated with Champagne and Streisand.