EAST RUTHERFORD, N.J. — Giants wide receiver Golden Tate has been suspended for four games for using a drug prescribed for fertility planning, another setback at the position in the team’s first season since trading Odell Beckham Jr.

In its opening practice on Thursday, Corey Coleman tore an anterior cruciate ligament and Sterling Shepard broke his left thumb.

Tate, a 10-year veteran who signed with the Giants as a free agent, announced the suspension in a Twitter post on Saturday. He said that he planned to appeal the violation of the N.F.L.’s policy on performance-enhancing drugs and that he would have no further comment.

The N.F.L. has not announced the suspension and it had no comment, a league spokesman, Brian McCarthy, said in an email on Saturday. Coach Pat Shurmur declined to comment, saying the team will see what happens.