BALTIMORE — They come and go as often as regulars on the Long Island Railroad, and All-Star catcher Gary Sanchez is preparing to return from the injured list for the second time this week.

Out since July 24 with a strained left groin, Sanchez is scheduled to begin a minor league rehab assignment Wednesday.

“Wednesday and Thursday with [Triple-A Scranton/Wilkes-Barre], catch both days and hopefully travel to us in Toronto and be an active player,’’ Aaron Boone said before his team beat the morbid Orioles, 9-6, at Camden Yards on Monday evening.

While the Yankees certainly miss Sanchez’s power potential (he leads the club with 24 homers) the combination of Austin Romine and Kyle Higashioka has been more than adequate filling in for Sanchez at the plate.

Romine homered Monday and the duo is hitting .293 (12-for-41) with four homers and 11 RBIs since Sanchez went down. From June 23 to July 23, Sanchez appeared in 21 games, hit one homer, drove in six runs and hit .118 (10-for-85) with a .370 OPS.

After the victory Monday, Boone announced Jonathan Holder will serve as the opener for the first time this season. Reliever Chad Green has started nine games this season, but threw 25 pitches as the opener in the second game of Saturday’s doubleheader against the Red Sox and threw 24 pitches as the closer Sunday night against Boston.

Out all season with shoulder issues, Luis Severino is moving closer to throwing off a mound. According to Boone, the former staff ace has one more flat-ground session Wednesday. If that goes well, the plan is for a bullpen session Friday in Toronto.

CC Sabathia threw on flat ground Monday for the first time since landing on the injured list on July 28 with right knee inflammation.

“See how he comes out of that, I am assuming everything was good,’’ Boone said. “Then we will start putting a plan moving forward.’’

Orioles manager Brandon Hyde had some critical words after his challenge of Jace Peterson being called out at home on an attempted double steal Monday night didn’t go as hoped, with the review supporting the call on the field.

“I thought it was joke to be honest with you. That was pathetic. I’m standing right on the line. It was clear as day to me and as well as the entire crowd on the replay in the stadium. I just thought it changed the whole momentum of the game at that point and I thought it was absolutely pathetic,’’ Hyde told reporters about the final out of the fourth inning. “New York saw it differently, I guess. Somebody saw something differently. Still trying to wait to see what the angle is because I saw about seven and they’re not even close.”

Hyde would like a new explanation.

“I’m hoping I get a letter. They say the same thing every time. That they have more angles than you and they see things that you can’t. But I’m standing right there, and it was a really terrible decision.’’

Yankees have won 10 straight games against the Orioles. They have won 13 straight at Camden Yards, the longest road streak by any team since 1954.

Jonathan Villar’s ninth-inning single off Aroldis Chapman didn’t turn into a run, but it did give Villar the cycle. He is the fifth Oriole ever to homer, triple, double and single in the same game.