Scientists have extracted the entire genome of a 130,000-year-old Neanderthal from a single toe bone in a Siberian cave, an accomplishment that far outstrips any previous work on Neanderthal genes.

The accuracy of the new genome is of similar quality to what scientists would achieve if they were sequencing the DNA of a living person.

“It’s an amazing technical accomplishment,” said Sarah A. Tishkoff, an expert on human evolution at the University of Pennsylvania, who was not involved in the research. “Twenty years ago, I would have thought this would never be possible.”

The new Neanderthal genome, which is described in the current issue of Nature, is part of an extraordinary flurry of advances in studying ancient human DNA. Earlier this month, for example, scientists reconstructed a small segment of genes from a 400,000-year-old fossil in Spain, setting a record for the oldest human DNA ever found.