In a new international collaborative study between The Chinese University of Hong Kong and Ann & Robert H. Lurie Children's Hospital of Chicago, researchers created a machine learning algorithm that uses brain scans to predict language ability in deaf children after they receive a cochlear implant. This study's novel use of artificial intelligence to understand brain structure underlying language development has broad reaching implications for children with developmental challenges. It was published in the Proceedings of the National Academy of Sciences of the United States of America.

"The ability to predict language development is important because it allows clinicians and educators to intervene with therapy to maximize language learning for the child," said co-senior author Patrick C. M. Wong, PhD, a cognitive neuroscientist, professor and director of the Brain and Mind Institute at The Chinese University of Hong Kong. "Since the brain underlies all human ability, the methods we have applied to children with hearing loss could have widespread use in predicting function and improving the lives of children with a broad range of disabilities" said Wong.

A cochlear implant is the most effective treatment for children born with significant hearing loss when hearing aids are not enough for the child to develop age appropriate listening and language ability. Decades of research have shown that early cochlear implantation is critical. Although a cochlear implant enables many children with hearing loss to understand and develop speech, some children lag behind their normal hearing peers despite receiving an implant as an infant or toddler. Helping these children achieve the language and literacy of hearing children is important and the focus of much research, as these skills are critical to academic success, social and emotional well-being and employment opportunities.

"So far, we have not had a reliable way to predict which children are at risk to develop poorer language. Our study is the first to provide clinicians and caregivers with concrete information about how much language improvement can be expected given the child's brain development immediately before surgery," said co-senior author Nancy M. Young, MD, Medical Director, Audiology and Cochlear Implant Programs at Lurie Children's, a surgeon and professor at Northwestern University Feinberg School of Medicine. "The ability to forcast children at risk is the critical first step to improving their outcome. It will lay the groundwork for future development and testing of customized therapies."

"A one-size-fits-all intensive therapy approach is impractical and may not adequately address the needs of those children most at risk to fall behind," added Wong.

Erin Ingvalson, assistant professor at Florida State University who began work on the project as a post-doctoral student at Northwestern University, said "our goal is to eliminate the gap in language outcomes often found when children with hearing loss are compared to those with normal hearing."

"The ability to optimize therapy for each child with hearing loss will transform many lives," said Ingvalson.

Successful hearing and spoken language development depends on both the ear and the brain. Hearing loss early in life deprives the auditory areas of the brain of stimulation, which causes abnormal patterns of brain development.

"We used MRI to capture these abnormal patterns before cochlear implant surgery and constructed a machine-learning algorithm for predicting language development with a relatively high degree of accuracy, specificity and sensitivity," Wong explained. "Although the current algorithm is built for children with hearing impairment, research is being conducted to also predict language development in other pediatric populations."

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Research at Ann & Robert H. Lurie Children's Hospital of Chicago is conducted through the Stanley Manne Children's Research Institute. The Manne Research Institute is focused on improving child health, transforming pediatric medicine and ensuring healthier futures through the relentless pursuit of knowledge. Lurie Children's is ranked as one of the nation's top children's hospitals by U.S. News & World Report. It is the pediatric training ground for Northwestern University Feinberg School of Medicine. Last year, the hospital served more than 208,000 children from 50 states and 58 countries.