Melifonwu was selected by the Raiders with the 56th overall pick in April's draft. He played in 48 games with 47 starts over his four-year career at Connecticut, finishing with 351 tackles (224 solo), eight interceptions, 16 passes defensed, two forced fumbles and two fumble recoveries. As a senior, he recorded a career- and team-high 118 tackles with four interceptions, three passes defensed and one fumble recovery on his way to being named to the All-AAC First Team.