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This is a big one. A study published in BMC Cardiovascular Disorders this week found that — in all ways measured — electronic cigarettes did not affect acute heart function while tobacco cigarettes did.

The study examined acute heart function in 36 smokers and 40 vapers both before and after smoking or vaping. After just one tobacco cigarette, subjects showed “significant changes in diastolic function parameters.” But by all measures, vaping caused no adverse effects after a solid 7 minutes of activity.

You can read more complete coverage of the study at Michael Siegel’s tobacco analysis blog.

This adds to a litany of other research that all appears to support the idea that e-cigs really don’t cause much harm. A previous study already showed e-cigs had no effect on acute respiratory function. It’s rapidly seeming like expert postulation that e-cigs are 99% less harmful that tobacco cigarettes is becoming proven theory.

Some e-cig opponents continue to claim that there is no proof e-cigs are any less harmful than tobacco cigarettes. Meanwhile, studies like this are becoming harder and harder to ignore — which is why many opponents have moved on to claims that e-cigs act as a gateway or are keeping people from quitting altogether.

All in all, this is a difficult study to argue against.