Two pedestrians are dead and another is in hospital with serious injuries after two separate collisions in the city overnight.

The first occurred around 11 p.m. Wednesday, when a female pedestrian was struck as she walked along the sidewalk on the north side of York Mills Road west of Don Mills. A blue Nissan Rogue travelling west on York Mills left the roadway, hit the woman, returned to the road and continued west, Toronto police Const. Clint Stibbe told CBC Toronto.

The victim, aged 63, was pronounced dead at the scene, according to CBC video producer Tony Smyth.

The vehicle fled the scene.

Investigators are looking for the Rogue, model year between 2014 and 2016, which will have damage to the front right side, Stibbe said.

"We are asking anybody if they know where that vehicle may be or who was operating that vehicle last night to contact us as soon as possible," Stibbe said.

"I'm also appealing to the driver of that vehicle: contact a lawyer and then contact police. You have a responsibility to deal with what has happened. And we also have a family now that's been destroyed as a result of your actions."

Pair struck after hailing taxi

Following that collision at around 3:30 a.m., two pedestrians in their twenties were struck on Yonge Street as they tried to cross mid-block just north of Lawrence Avenue. Stibbe said the pair had hailed a taxi and were crossing the road to meet it when they were hit by a southbound vehicle.

A male and female were struck as they tried to cross Yonge Street near Lawrence Avenue early Thursday morning. (Tony Smyth/CBC)

A female was rushed to hospital without vital signs, Stibbe said. She later died in hospital, police said. The second person, a male, was rushed to hospital in serious condition, paramedics told CBC Toronto.

The driver of the Toyota that struck the victims remained at the scene.

"The reality is this collision didn't have to happen," Stibbe said. "But the responsibility doesn't just fall to the pedestrians, it also falls to the drivers, as well."

Police closed Yonge Street in both directions, but have since reopened the road.