And globally, Infinity War could eclipse The Fate of the Furious ($541.9 million) to land the biggest box-office launch of all time. That's without the benefit of China, where it doesn't land until May 11.

Infinity War has already earned a mighty $178.5 million internationally in its first three days (Wednesday through Friday) for an early global total of $284.5 million.

Friday's North American gross was $106 million, the second-best single day in history behind the $119.2 million earned by Force Awakens on its first day. Until now, Avengers: Age of Ultron sported the biggest single day for a superhero pic ($84.4 million).

It's a Marvel superhero bonanza all the way around as Black Panther moves up the chart from No. 8 to No. 5 in its ninth weekend with projected earnings of $3.6 million.

To date, The Avengers ($207.4 million) holds the record for the biggest superhero launch, followed by Black Panther ($202 million). They are the only two superhero titles to have crossed $200 million in their first weekend.

After Force Awakens, the biggest North American openings belong to Star Wars: The Last Jedi ($220 million) and Jurassic World ($208.8 million).

Directed by the Russo brothers, Infinity War reunites the Avengers gang and friends, including Iron Man (Robert Downey Jr.), Black Panther (Chadwick Boseman ), Thor (Chris Hemsworth ), Captain America (Chris Evans), Black Widow (Scarlett Johansson) and the Hulk (Mark Ruffalo ), as they join forces with the Guardians of the Galaxy crew to stop the evil intergalactic despot Thanos (Josh Brolin ).

The success of Disney and Marvel's Black Panther could be a huge boost for Infinity War. Black Panther has earned $681 million in North America to become the No. 3 film of all time behind Force Awakens ($936.7 million) and Avatar ($760.5 million). Globally, it has earned $1.325 billion to rest at No. 10 of the all-time biggest earners.

Overseas, Infinity War scored the biggest opening day in a slew of markets, including South Korea — where it has earned $11.4 million in its first two days — Brazil, the Philippines, Thailand, Indonesia, Malaysia, Hong Kong, Vietnam, Central America, Chile, Peru, Bolivia and the United Arab Emirates.

April 27, 12:15 p.m. Updated with revised estimates.

April 27, 9:30 p.m. Updated with revised estimates.