An Israeli couple yesterday broke the record for the world’s longest kiss – and ended up in the hospital for their effort.

Dror Orpaz and Karmit Tsubera puckered up in the main square of Tel Aviv and launched into the marathon smooching session late Monday.

They were among 300 couples who participated in a kissing marathon sponsored by a toothpaste company.

As a crowd of supporters cheered, the couples began with passionate embraces – and some with very intense making out.

But as the hours ticked by, sensuality turned to sluggishness as the puckering pairs began to tire.

One by one, the contestants dropped out until only Dror and Karmit were left.

They finally called it quits yesterday morning after 30 hours and 45 minutes of lip-locking.

And after breaking their embrace, the brave bussers nearly passed out, and had to be rushed to a local hospital.

There, they were treated for fatigue and given medical checkups. For their troubles, they won a trip around the world and $2,500 in cash.

The previous kissing record – 29 hours and 57 minutes, as recorded by “The Guinness Book of World Records” – was set last year in New York.

In that contest, the Michigan husband-and-wife team of Roberta and Mark Griswold outlasted eight other couples. They said the key to their victory was “practicing for 16 years.”

Earlier this year, an Australian couple tried, but failed, to break the Griswolds’ record, quitting after just 15 hours and 57 minutes.

The longest movie kiss lasted 185 seconds, between Jane Wyman and Regis Toomey in the 1940 film “You’re in the Army Now.”