Former Vice President Joe Biden Joe BidenThe Memo: Warning signs flash for Trump on debates Senate Republicans signal openness to working with Biden National postal mail handlers union endorses Biden MORE said on Sunday that President Trump Donald John TrumpBarr criticizes DOJ in speech declaring all agency power 'is invested in the attorney general' Military leaders asked about using heat ray on protesters outside White House: report Powell warns failure to reach COVID-19 deal could 'scar and damage' economy MORE would beat Sen. Bernie Sanders Bernie SandersSenate Republicans signal openness to working with Biden Hillicon Valley: DOJ indicts Chinese, Malaysian hackers accused of targeting over 100 organizations | GOP senators raise concerns over Oracle-TikTok deal | QAnon awareness jumps in new poll Schumer, Sanders call for Senate panel to address election security MORE (I-Vt.) in a general election.

Asked by NBC's Chuck Todd Charles (Chuck) David ToddSunday shows - Trump team defends coronavirus response Strzok: 'I continue to believe that Donald Trump is compromised by the Russians' GOP chair defends Trump messaging on masks: 'To say that he should have known then what we know now isn't really fair' MORE on "Meet the Press" if Sanders would lose to the Republican incumbent in the fall, Biden said, "I do."

“I think Bernie Sanders’s positions on a number of issues, even in the Democratic Party, are very controversial," Biden said, noting the hefty price tag of the senator's signature "Medicare for All" proposal.

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“Everybody’s going to look at Bernie’s record as closely as they’ve looked at mine over the last five months, and I think they’re going to see some stark differences in where we stand.”

Biden's comments followed his win in Saturday's South Carolina primary. Sanders is still leading the 2020 Democratic presidential field after the first four voting states.

Biden has been making the case that his more moderate proposals would help Democrats against Trump, arguing that Sanders's progressive agenda and democratic socialist label could hurt the party and down ballot candidates.

The candidates will next face off on Tuesday, when the largest number of states will hold primaries and caucuses.

A spokesperson for the Sanders campaign was not immediately available for comment.