Gunfire at a party in Houston, Texas has left two people dead and at least 22 others wounded, police have said.

The shooting occurred late on Saturday night at a large house party, attended by more than 100 people, most of whom were young adults.

A statement from the Harris County Sheriff’s Office said two suspects were being sought, following the incident which occurred in the Cypress area of the city’s suburbs.

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Police said a man and a woman were killed, and that the injuries to others ranged widely from the minor to critical. None of the victims were identified.

Thomas Gilliland, a spokesman with the sheriff's office, told the Houston Chronicle today that some of the wounded received shots to the foot, ankle and hip, while the less serious injuries including twisted ankles as partygoers fled the home.

“It was a pretty chaotic scene,” Mr Gilliland said.

There was no immediate word on how many shots were fired or a possible motive for the incident.