DETROIT — A type of Takata air bag inflator once thought to be safe has now come under scrutiny after a crash and explosion in Maryland injured the driver of a Honda minivan.

The incident forced Honda HMC, -0.73% 7267, -2.81% on Tuesday to recall about 1.2 million vehicles in North and Central America from the 2001 to 2016 model years to replace inflators that had not been included in the massive string of Takata recalls for air bags that can hurl shrapnel into the passenger compartment.

Takata 1966, +0.14% used ammonium nitrate to create a small explosion and inflate air bags in a collision. But the chemical can deteriorate when exposed to high temperatures and humidity and blow apart a metal canister, spewing out shrapnel. At least 23 people have been killed by the company’s inflators and hundreds more injured.

The inflators in the Tuesday recall contain a moisture-absorbing chemical called a desiccant that was added to keep the ammonium nitrate stable. They were believed to be safe, and were used to replace older inflators under recalls that began in 2014.

But Honda and the U.S. National Highway Traffic Safety Administration said that a crash on Jan. 19, 2018 involving a 2004 Honda Odyssey initiated an investigation and Tuesday’s recall when investigators discovered that the driver’s air bag inflator ruptured. The probe determined that inflators made at Takata’s Monclova, Mexico, factory were faulty due to a manufacturing defect, Honda said. The driver suffered an arm injury.

NHTSA, the government’s highway safety regulator, said in a statement Tuesday that only Honda used this particular type of Takata inflator made at the Mexican factory. At this time, the agency believes the Honda problem has been isolated and is caused by a manufacturing issue.

The Honda vehicles will be recalled a second time to replace the inflators. Also included in the recall are vehicles that received inflators due to collision repairs.

The recall covers certain Honda and Acura models largely in the U.S. and Canada. Included are the 2001 to 2007 and 2009 Honda Accord, the 2001 to 2005 Civic, the 2002 to 2007 and 2010 and 2011 CR-V, the 2003 to 2011 Element, the 2007 Fit, the 2002 to 2004 Odyssey, the 2003 to 2008 Pilot, and the 2006 to 2014 Ridgeline pickup. Also included are certain 2003 Acura 3.2CL cars, as well as the 2013 to 2016 ILX, the 2003 to 2006 MDX, the 2007 to 2016 RDX, the 2002 to 2003 3.2TL, the 2004 to 2006 and 2009 to 2014 TL, and the 2010 to 2013 ZDX.

NHTSA said not all vehicles that received replacement air bag inflators are affected. Some had replacement parts from other manufacturers that are safe. The agency urged owners to check for open recalls by keying in their 17-digit vehicle identification number on the NHTSA website www.nhtsa.gov/recalls .

Honda said in a statement that owners will be notified by mail in early April, but replacement parts from manufacturers other than Takata are available to begin the recall immediately. Honda is offering free loaner cars while vehicles are being repaired.

A NHTSA investigation into Takata air bag inflators remains open. Under the terms of an agreement with the agency, Takata has until the end of this year to prove that inflators with the moisture-absorbing chemical are safe or they all will have to be recalled.

The Takata recalls together are the largest series of automotive recalls in U.S. history, with as many as 70 million inflators to be recalled by the end of next year. About 100 million inflators are to be recalled worldwide.