Rosie O’Donnell continued her sustained attack on Donald Trump Wednesday, delivering a profanity-laced tirade in which she called the GOP presidential frontrunner an “orange piece of sh*t” and repeatedly stated that she hates him.

Rosie O’Donnell was onstage at the Beacon Theatre in New York City ahead of a Boy George concert when she opened up her short remarks by immediately going after Trump, with whom she has feuded since 2006, according to the Daily Mail.

O’Donnell reportedly told the audience that she was “depressed because I f*cking hate that orange piece of sh*t.”

O’Donnell also referred to the GOP frontrunner as a sh*t-stain with a tinge of orange,” and at one point, grabbed her crotch before exclaiming, “Eat me, Donald.”

“I would rather give birth to a flaming iguana while taking a sh*t,” the comedian said she told her therapist after being advised not to focus on Trump. “I hate him. I hate him.”

O’Donnell’s act reportedly received a mixed reaction from the New York City audience.

“Not everyone was impressed,” one attendee told the Daily Mail. “People around me were shaking their heads in disagreement.”

O’Donnell and Trump have feuded off-and-on since 2006. The feud began when O’Donnell questioned Trump’s decision not to strip then-Miss USA Tara Conner’s crown over her reported drug use. Trump fired back by calling O’Donnell a “loser.”

The two have traded insults back and forth for years, with the latest attack coming earlier this month when O’Donnell predicted Trump “will never be president” and said his mouth “looks like an anus.” In April, she called the GOP frontrunner a “bully” who is “not even qualified to run a game show.”

O’Donnell has vowed to move to Canada if Trump wins. In an appearance on Fox News Channel’s Fox and Friends last month, Trump said O’Donnell’s, and other celebrities’, plan to move if he wins would be “a great thing for our country.”

Follow Daniel Nussbaum on Twitter: @dznussbaum.