TAMPA — Luis Severino was stuffed into the Carl Pavano Memorial MRI tube before he could make his first exhibition start on Tuesday, and thanks to inflammation in his right rotator cuff, the Yankees ace won’t be available to face the Orioles on Opening Day in The Bronx.

Eleven days into the spring-training schedule, the Yankees don’t exactly know when Severino will reappear on a mound, which is uncomfortable.

While throwing in the bullpen before the Braves-Yankees game at George M. Steinbrenner Field on Tuesday, Severino unleashed his first slider of the day and felt something in right shoulder, then smartly told the medical staff.

“He is running out of time, even in the best-case scenario, because he is shut down for two weeks at a minimum,’’ manager Aaron Boone said about Severino not facing the Orioles on March 28.

So who replaces Severino on Opening Day?

“We will talk about that, kind of look and see,’’ said Boone, who will be without CC Sabathia for at least the first five games of the regular season while he serves his suspension. “Hopefully I will have that for you pretty soon, but I don’t want to jump into anything right after this.’’

Boone has the trio of Masahiro Tanaka, James Paxton and J.A. Happ to choose from to replace Severino. Luis Cessa was the favorite to take Sabathia’s turn in the first trip through the rotation. Severino’s situation, barring a trade or signing free agent Dallas Keuchel, now puts Jonathan Loaisiga and Domingo German in play for an early-season start.

When camp opened, Boone said he would use five starters in the first five games. However, with a day off between the first and second games, Boone could use a four-man rotation. And with five dark days on the schedule in late March and April and the possibility of inclement weather, Boone and pitching coach Larry Rothschild could do some additional juggling.

According to Boone, Severino will receive an injection and take anti-inflammatories. Hopefully in two weeks he can start back with his throwing program.

Encouraging to Boone was that the test didn’t unearth anything structurally wrong.

“Otherwise the MRI looked pretty good,’’ Boone said.

Happ said Severino did the smart thing after that first slider in the bullpen left him with discomfort.

“I think he did the right thing and not push it,’’ Happ said. “He could have made it worse.’’

Boone believed the MRI exam went well, but when your ace walks off a bullpen mound in early March and the test shows something wrong in the dreaded rotator-cuff area, there is a level of concern.

“Obviously, any time a starting pitcher and a guy like Sevy walks off while he is warming up to start a game, you always get worried and concerned about that,’’ Boone said. “But it sounds like the shoulder is pretty clean, that it is an inflammation issue. If that is the case, hopefully two weeks is something that will do the trick and he can start ramping back up. We will re-evaluate at the two-week point to see if all of that inflammation is out of there.’’

Boone and Rothschild don’t label pitchers aces, but there is no denying the 25-year-old’s worth to the Yankees, who recently dropped a four-year contract on him for $40 million. Severino is 33-14 with a 3.18 ERA in the past two seasons, when he made 63 starts.

Severino has been on the injured list once in his career. That was in 2016 with a right forearm strain that cost him two-plus weeks. The Yankees have their fingers firmly crossed this inflammation doesn’t lead to a second stint on the shelf.