DNP (2,4

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Dinitrophenol) FAQ

A Gu i de b y P ri ma lk i d

Is DNP safe?

If used properly, DNP is safe, effective, and has arguably less problems than other c ompounds. However,

given the propensity of dieters to fall into a “more is better” trap

and the fact that a single overdose of DNP will kill you without fail, it is best that 99.99% of people cannot get acce ss to it.

How does DNP work?

DNP inhibits energy (ATP) production within mitochondria by uncoupling oxidative phosphorylation, which allows hydrogen ions (H+) to leak across the membrane and results in a rapid consumption of energy without generation of ATP. In other words, DNP causes inefficiency in ATP production and more substrate will be consumed and the wasted energy dissipated as heat. Interestingly, this is a very similar mechanism to brown fat cells. These specialized fat cells are packed with mitochondria that leak part of their H+ gradient futilely back across the membrane for the sole purpose of producing heat. Thus, DNP

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