The Panthers have asked for medical advice on how to safeguard against the remote possibility of the mumps outbreak that has affected members of the Roosters squad infiltrating their own camp during Saturday's trial game.

Just three weeks out from the start of the NRL season, Penrith have been working closely with medical personnel, as well as the Tricolours, to ensure the viral infection doesn't creep into a second NRL squad.

Going viral: Mitchell Aubusson was the first to contract the ailment. Credit:AAP

The two sides are preparing for their first hit-out of the season at Panthers Stadium, which will see James Maloney make his maiden appearance in Penrith colours alongside Nathan Cleary.

Roosters veteran Mitchell Aubusson was the first to be laid low by the ailment, which has now forced NSW No.1 and star recruit James Tedesco to rest before he pulls on the red, white and blue for the first time.