A townhouse-condominium unit, and its connecting skybridge in Manhattan’s Tribeca neighborhood, hit the market Wednesday for $35 million.

The brick townhouse has one finished bedroom, with an en-suite bathroom and a walk-in closet, in addition to lots of open space. There is more than 8,170-square-feet of loft space between the townhouse and the accompanying 2,300-square-foot condo unit.

Having so much open loft space makes the property like an empty canvas, said Mara Flash Blum and Kaptan Unugur, co-listing agents at Sotheby’s.

"You can easily make this into a mansion with five or six bedrooms," Ms. Flash Blum said. "It’s set up so you bring your imagination with you to the space...It’s such a unique find in Manhattan."

The townhouse on Jay Street and the neighboring condo building, which includes the townhouse-attached unit, were once part of New York Hospital—which is now located uptown and part of New York-Presbyterian Hospital. The townhouse was the ambulance center, and the adjacent building was the rest of the hospital during the 1800s.

The skybridge was originally built to safely transfer patients between wards, Ms. Flash Blum said. Mansion Global could not independently confirm when the bridge was built.

The bridge, which goes over Staple Street is iconic, Mr. Unugur said. People have "seen the bridge in films and in photographs."

The connected properties were last listed by Brown Harris Stevens for $50 million in May 2016. The listing was taken down in December, according to Zillow.

"It’s really hard to price something when there’s just so much history behind it and there’s just no comparison," because of the bridge, townhouse, and condo, Mr. Unugur said.

It’s back on the market for $15 million less because the owner is eager to sell, the agents confirmed.

From Penta: Designing a Home in the Sky

The townhouse and condo unit are owned by Zoran Ladicorbic, who purchased the properties through his corporate name in 1985, property records show. Mr. Ladicorbic, a Serbian fashion designer, used one part of the space for living and worked in the other part, the agents said. Mr. Ladicorbic could not immediately be reached for comment.

"The way [Mr. Ladicorbic] would design his garments is the way he designed his house. It’s very minimal and streamlined," Mr. Unugur said.

There are four bathrooms in the property, two of which are half-bathrooms, according to the listing. Mr. Ladicorbic did not make any major renovations after he purchased the properties, by which point the properties had already been converted for living use. However, he did add new tiling and stone when he moved in, Mr. Unugur said.

With nearly 11-foot-tall ceilings and a 1,175-square-foot roof deck, the house has exposures south, west, north, and east of the property, according to the listing. Exclusive use of the bridge connecting the properties costs around $5,500 every year for a 10-year license, paid to the city Department of Transportation, the agents said.