Danny Rose is set for decisive talks with Tottenham Hotspur this week after a breakdown of his relationship with manager Mauricio Pochettino, sources have told ESPN FC, with Manchester United interested in the defender.

Rose's agent, Mark Rankine, is due to meet to Daniel Levy for crunch talks on Wednesday but the Spurs chairman is expected to reiterate that Rose is not for sale, despite the left-back's desire to leave the club before the transfer deadline.

The sources said that Rose and Pochettino have not spoken privately since the defender's explosive interview with a national newspaper a fortnight ago, even after Rose issued a written apology.

The England international, who was fined two weeks wages' for the outburst, was once so close to Pochettino that he was jokingly referred to as the "gaffer's son" by his teammates but their relationship, which was already cooling, has deteriorated since Rose broke ranks and criticised the club's transfer policy and wage structure.

United boss Jose Mourinho said afterwards that he had "nothing to do with interview" and that Pochettino and Levy "would not be happy" if he commented on the situation.

The sources said United are interested in Rose, although Spurs are yet to receive any bids this summer, and the Yorkshireman -- who has said he will play in the north of England before he retires -- would welcome the chance to move to Old Trafford.

But, with fewer than 10 days remaining in the transfer window, Rose is increasingly resigned to staying at Spurs for now. The 27-year-old has not played since January due to a knee injury and he is not expected to return to full training until next month at the earliest, which further dampens his chances of leaving the club before Aug. 31.

In the interview with The Sun on the eve of the new season, Rose -- who signed a five-year contract worth around £65,000-a-week last September -- questioned Tottenham's ambition, said he should be earning more money and admitted he was open to offers from other clubs.

Speaking on Aug. 11, two days after Rose's interview, Pochettino said he was yet to speak to him but insisted their relationship remained intact, saying: "Nothing has changed in my perception of him."

Pochettino and Levy have the final say on who to buy and sell and, if the club does not allow Rose to leave this month, the manager faces a difficult decision. No player who has crossed Pochettino has ever played for Tottenham again, and Pochettino could either integrate Rose back into the squad when fit or choose not to select him.