The above is quite general purpose and does not commit to any hypotheses regarding what may be the underlying causes or dynamics of aging, but in fact we do have some specific hypotheses we are following up …

I have been investigating for a long time the potential role of mitochondria in aging, since working on this paper back in 2005, AI for Understanding and Curing Aging … where we showed that mutations in certain regions of mitochondrial DNA were very strongly correlated with Parkinsons Disease (and we found, but did not publish, similar results regarding Alzheimers) …

It seems to me that analyzing the Mito-Age dataset (http://www.mitoage.info ) of cross-species mitochondrial DNA data – together with relevant aspects of the nuclear DNA of the same species – could be quite informative regarding the energetic basis of aging…

On the other hand, Alexander Fedintsev and our SingularityNET Director of Biomedical Projects Denis Odinokov and others have emphasized the potential strong role of stiffening of the extracellular matrix (ECM) in aging, and this fascinates me because I know there is so much signaling (both chemical and biophotonic) going on in the ECM … indeed this ECM-based signaling appears likely to me to be related to how acupuncture and other aspects of traditional Chinese medicine work…

ECM is part of the story, mitochondria are part of the story – there are many interlocking feedback involved in aging and we need to unravel and model many of them using available data and AI tools, and then work in close collaboration with laboratory biologists to run experiments suggested by our AI tools to gather yet more data, and then we have a good chance of solving the problem…

This can be very big business-wise but even more interestingly it has real potential to dramatically minimize involuntary death…