For the past 18 months, Ginni Thomas, the wife of Justice Clarence Thomas, and other conservatives have plied the White House with memos and suggestions about which people to fire — and who should replace them.

President Trump has generally treated Ms. Thomas’s suggestions coolly, passing them off to advisers, according to people familiar with Ms. Thomas’s efforts. But since the end of the Senate impeachment trial, the president has become more distrustful of the people filling the ranks of government and has been giving those recommendations a closer look.

The memos from Ms. Thomas were first reported by Axios.

Among Ms. Thomas’s top targets have been officials at the National Security Council, the former head of the White House personnel office, Sean Doocey, and other top White House aides. Another target was Jessie K. Liu, who recently left her job as the U.S. attorney for the District of Columbia for a job in the Treasury Department that was later withdrawn by the White House.

Ms. Thomas, a politically active conservative who for nearly seven years has led a group called Groundswell, also successfully lobbied for a role for Kenneth T. Cuccinelli II, the former attorney general of Virginia who is now the acting deputy secretary of homeland security.