Rhys Hoskins laughed long and loud Wednesday night, taking a baseball eternity to let it resonate.

The Phillies slugger got a rematch with Jacob Rhame from the previous night and delivered retribution, with a two-run homer in the ninth inning that put the icing on the Mets’ 6-0 loss at Citi Field.

But it was Hoskins’ home-run trot — lasting 34 seconds — that added further insult for the Mets, who missed in their attempt to complete a three-game sweep against their NL East rival.

A night earlier Hoskins was clearly upset at what he perceived as headhunting tactics by Rhame in the ninth inning of a Mets blowout victory.

“[Hoskins] didn’t get hit by the pitch, but he thought he would slow-play it around the bases,” Todd Frazier said. “It’s something that I guess is a part of it. What are you going to do? He hit a home run, so I really haven’t thought that much into it. We’ll see. We’ve got a lot more games to play.”

Thirteen more games, to be exact. The rivalry resumes in Philadelphia on June 24.

Tensions had escalated Tuesday as Rhame threw a pitch over Hoskins’ head in the ninth inning. Rhame’s ensuing pitch came high-and tight to Hoskins.

Rhame downplayed any potential animosity over Hoskins’ home-run trot.

“He got me,” Rhame said. “If I make a better pitch he doesn’t get to run the bases.”

Frazier was drilled by a Vince Velasquez pitch leading off the fourth inning Wednesday, continuing a trend this season of Mets batters getting plunked. Entering play the Mets led the NL, with 15 of their batters hit. Included were Jeff McNeil and Pete Alonso earlier in this series.

“For now I don’t feel anything has been intentional at us that has warranted anything from our side,” manager Mickey Callaway said before the game.

And Callaway later downplayed Hoskins’ deliberate home-run trot.

“That’s their team, they can do whatever they want to do,” Callaway said.

Velasquez (1-0) frustrated the Mets over five innings, in which he surrendered three hits and three walks. All six of the Mets’ hits in the game were singles.

The Phillies broke it open in the eighth, scoring three runs on five hits against Robert Gsellman, who had rebounded recently from a rough stretch to begin the season. Hoskins’ triple leading off the inning — a ball Brandon Nimmo couldn’t quite reach in center — ignited the rally.

Jason Vargas gave the Mets a chance by allowing one earned run on three hits and two walks over 4 ²/₃ innings. The lefty was removed at 89 pitches in the fifth with two outs, after striking out Bryce Harper (for the second time) with two runners on base. Vargas’ ERA dropped from 9.58 to 7.20 in what ranked as his best performance of the season.

But Vargas has completed five innings in only one of his four starts this season.

“I have been more accustomed to pushing deeper into games,” Vargas said. “But at the same time, the way it was situated at the beginning of the season, where we’re at [in the lineup] kind of determined the way it played out.”

Harper’s RBI double in the first put the Mets in a 1-0 hole, but the damage could have mounted. Instead, Vargas retired Maikel Franco and Cesar Hernandez in succession to escape the inning. The Phillies’ only other noises against Vargas were the result of an error by Amed Rosario in the second and a single off Frazier’s glove in the fifth.

Frazier, who hit a grand slam on Tuesday, was retired with the bases loaded in the first to end a threat. The Mets had runners on second and third following a wild pitch in the third, but Wilson Ramos and Dominic Smith struck out in succession to end that threat.

“We lost the game 6-0. That’s all I can really think about right now and we’ll go from there,” Frazier said. “We won the series, and that’s the exciting part for us. Nobody is down, everybody is where they should be.”