Antonio Williams, 25, has been charged

A man has been arrested in connection with the gruesome murders of his sister and cousins - all under the age of 10 - who were found dead inside a Maryland home.

Antonio Williams, 25, was taken into custody by local police late on Friday night and cops say he has confessed to the killings.

Williams lives on Brooke Jane Drive, which is the same street as the home the three little girls were found dead in that morning in Clinton, Maryland.

He had been left at the home to look after the girls - his sister, six-year-old Nadira Withers, and cousins nine-year-old Ariana Decree and six-year-old Ajayah Decree - by his mother, Andrena Kelley.

The cousins were from Newark, New Jersey and are the daughters of the suspect’s mother’s cousin.

The bodies were reportedly found by Kelley who then called the police. The victims were suffering from stab wounds and pronounced dead on the scene.

Williams has been charged with three counts of first-degree murder and three counts of second-degree murder. Cops say he has confessed to stabbing and killing his relatives.

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Prince George's County police are investigating the deaths of three juveniles, aged five to nine, who were found dead in a house by a relative early on Friday morning

Antonio Williams, 25, was arrested in connection with the murder of the three girls. He lives on the same street that the bodies were found

Video courtesy of WJLA

Two of the victims were from Newark and were on vacation in Maryland, according to sources speaking to RLS Metro Breaking News.

'We are now in the midst of a major investigation into what happened to these children and who killed them,' police department spokeswoman Jennifer Donelan said. 'We have not determined who the person responsible is yet,' she said.

Firefighters arrived and pronounced the children dead.

In a news conference with reporters police described the scene inside the home as 'gruesome'.

'This is one of the the most difficult scenes that our officers arrived on,' Donelan said, adding that the neighborhood where the children were found was quiet.

State's Attorney Angela Alsobrooks, said: 'We are absolutely heartbroken and we are so absolutely devastated.'

'We are now in the midst of a major investigation into what happened to these children and who killed them,' police department spokeswoman Jennifer Donelan said (pictured)

Antonio Williams, 25, was taken into custody by local police late on Friday night

Relatives of the victims are being contacted and counseling has even been offered to officers who responded and found the bodies.

An extensive investigation is underway.

Another press conference is expected at 11am on Saturday.