Oprah and Reese Witherspoon got in on the joke after an embarrassing photoshop error by Vanity Fair gave them both extra limbs.

'Well I guess everybody knows now I have three legs', wrote Reese on Twitter after seeing the disastrous job done on the Annie Leibovitz shoot for the magazine's annual Hollywood issue.

She also added for good measure, 'I will never apologize for snuggling' (Winfrey).

Finding it equally amusing, Oprah replied to Reese, 'I accept your third leg. As I know you accept my third hand.'

And for their part, while admitting they made an error with Oprah, Vanity Fair denied they gave Reese three legs, claiming it was an optical illusion caused by the lining of her dress.

Whoops! Oprah Winfrey, 63, was accidentally given three hands while posing with Reese Witherspoon and Tom Hanks for Vanity Fair's 24th annual 'Hollywood' issue

Another mistake? People took to Twitter to point out that it looks like Reese has three legs in the photo featured on the magazine's cover

Laughing it off: 'I guess everybody knows now...I have 3 legs,' Reese joked on Twitter

Jokes: Oprah responded to Reese's tweet, telling her she accepts her third leg

A-list: Nicole Kidman, Tom Hanks, Michael B. Jordan, Zendaya, Jessica Chastain Claire Foy, Michael Shannon, Harrison Ford, Gal Gadot, Vanity Fair editor Graydon Carter and Robert De Niro (L-R) all appear on the new cover

The magazine's 24th annual 'Hollywood' issue had Oprah, 63, posed up for renowned photographer Annie Leibovitz, alongside A-list stars such as Robert De Niro and Nicole Kidman, with Reese Witherspoon sitting on her lap.

Although the pictures are undoubtedly stunning, there appears to be not one but two major Photoshopping mistakes that went unnoticed before publication.

In one of the images, Oprah has a hand on her hip, a hand on her lap, and then a third hand wrapped around Reese's waist.

The two appear to be laughing at something Tom Hanks said, and while Oprah's hands are firmly in front of her, four of her fingers are hugging her A Wrinkle in Time co-star's side.

The blunders was pointed out just hours before Vanity Fair revealed they had digitally removed James Franco from the cover after the learned about his sexual misconduct allegations.

The mistake prompted people to poke fun of the magazine on Twitter, joking that the superstar does indeed have three hands.

'Listen Oprah might have three hands,' Jason Abbruzzese wrote, while Steve Bayorgeon added: 'Everyone knows Oprah has three hands.'

Owning it: Vanity Fair replied to Reese Witherspoon after their photoshop to deny they gave her three legs but admitted Oprah did have three hands

Confused: A woman named Nichole circle Reese's 'three legs' in the cover photo, noting her flesh is not the same color as the inside of her dress

Just saying: A Twitter users named Zoe joked that Reese's extra leg helps her get things done

'"Ole Three-Hands Oprah". That's what her friends call her,' someone else teased.

And one person couldn't resist mentioning Oprah's potential run for president.

'Now that Oprah has been exposed as an alien with three hands, her prospective presidential candidacy takes on more sinister overtones,' Yair Rosenberg commented.

Three may be Vanity Fair's lucky number, as people also took to Twitter on Thursday to point out that it looks like 41-year-old Reese has three legs on the cover.

Check this out: People first noticed Reese's alleged three legs, but soon people were commenting on Oprah's third hand

Just saying: Jason Abbruzzese joked that it is possible that Oprah has three hands

Staying positive: Christine Jackson reminded people that their days aren't nearly as bad as the person who accidentally gave the stars extra appendages

Interesting thought: One person couldn't resist mentioning Oprah's potential run for president

Three cheers! Tyler Oakley pointed out that 2018 is all about body acceptance

'I do wonder about Reese’s 3 legs?' someone named Nichole wrote. 'Her flesh is not the same color as the inside of her dress.'

'If you're struggling at work today, just remember that you aren't the person who let photos of Reese Witherspoon with three legs AND Oprah with three hands go to print,' Christine Jackson joked.

Meanwhile, someone named Zoe credited Reese's third leg for her success.

'How does Reese Witherspoon get so much done all at once?' she wrote. 'She produces and stars in movies and TV shows, owns a fashion line, and helps organize the Time’s Up movement all at the same time? Well, it’s probably because she has three legs.'

Out and about: Reese was all smiles on Thursday while taking her son Tennessee James Toth to school in Los Angeles

Mom on duty: The actress held her youngest son's hand during the school run

Advocate: Reese supported the 'Time's Up' movement while wearing a black sweater representing the cause

The possible snafu caught so much attention, Reese actually responded to the controversy on Twitter.

'Well...I guess everybody knows now...I have 3 legs,' she wrote. 'I hope you can still accept me for who I am. ( and I will never apologize for snuggling @Oprah .. if you get the opportunity, I highly recommend it.'

The actress was all smiles on Thursday while taking her son Tennessee James Toth to school in Los Angeles.

Reese, a vocal advocate for gender equality, supported the 'Time's Up' movement while wearing a black sweater representing the cause.

She paired the top with cropped, flared jeans and leopard ankle boots for the quick school run.