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Actress Lori Loughlin was all smiles as she headed into court on Wednesday — then turned on the star power inside as she shook hands with the prosecutors seeking to convict her in the $25 million college-admissions scam.

Loughlin and her husband and co-defendant, fashion designer Mossimo Giannulli, arrived with lawyers and at least one bodyguard about 30 minutes ahead of their scheduled appearances in Boston federal court.

Asked how she was holding up, the fired “Full House” and “Fuller House” actress told The Post, “I’m great!”

“How are you?” she added while patting a reporter on the arm.

Inside the courtroom, Loughlin, 53, flashed a 1,000-watt smile as she approached the prosecution table and shook hands with each of the four feds handling her case.

Another defendant, former “Desperate Housewives” star Felicity Huffman, was far less ebullient when she arrived around 11 a.m. for the 2:30 p.m. hearing — without her husband, “Shameless” star William H. Macy.

Instead, a grim-looking Huffman walked up holding hands with her older brother, Moore Huffman Jr., and ignored questions.

The actresses are among 33 wealthy parents accused of paying bribes to grease their kids’ way into college in a long-running scheme masterminded by California-based consultant William “Rick” Singer.

He began secretly cooperating with the feds against his clients last year and pleaded guilty hours after initial results of the ongoing investigation — dubbed “Operation Varsity Blues” — were announced on March 12.

Loughlin and Giannulli, 55, allegedly schemed with Singer to pay $500,000 so daughters Isabella Rose and Olivia Jade Gianulli could get recruited for the USC women’s crew team, even though neither were high-school rowers.

Both sisters left school over the scandal, and Olivia Jade — who was fired as an Instagram influencer for Sephora cosmetics and TRESemme hair-care products — isn’t talking to her parents, US Weekly reported last week.

Huffman is accused of paying Singer $15,000 to have the answers on daughter Sophia Grace Huffman’s SAT exam doctored to add 400 points to her score.

Sophia is a high school senior and was “in the thick of college application time” earlier this year, according to a January interview her dad gave Parade magazine.

All of the parents are charged with conspiracy to commit mail fraud and honest services mail fraud, which carries a maximum 20 years in prison.

Prosecutors want them to serve time regardless of whether they plead guilty or get convicted at trial, reports said Wednesday.

A law-enforcement official with knowledge of the matter predicted the parents would likely each wind up with sentences of between six and 21 months, CNN reported.

“You can’t have people being treated differently because they have money,” an unidentified fed told TMZ.

“That’s how we got to this place. Every defendant will be treated the same.”

As many as 10 parents are expected to strike plea deals by mid-April, according to CNN, and court papers filed Wednesday revealed that one defendant — Peter Sartorio, co-founder of the San Francisco-

based Elena’s Food Specialties frozen-food company — was planning to cop a plea on April 30.

Another defendant — Devin Sloane, founder of the Aquatecture water-systems company of Los Angeles — is also “currently in discussions that are calculated to resolve this matter without a trial,” according to court papers.

On her way out of the courthouse, Loughlin was greeted by about 20 young women who swarmed around her and snapped photos with their cellphones.

They included Bentley University juniors and “Full House” fans Lianna Ferrara, 20, and Alyssa Stevens, 21, who had earlier chanted “Free Aunt Becky!” while waiting for Loughlin to show up.

“We love you, Lori!” they screamed as Loughlin and Giannulli hopped into a black SUV and were driven away.