WASHINGTON (Reuters) - U.S. President Donald Trump’s expected nomination of former pizza chain executive Herman Cain to the Federal Reserve appeared in jeopardy on Thursday after a fourth Republican senator voiced opposition, possibly denying Cain the support needed to be confirmed in the post.

FILE PHOTO: Former presidential candidate Herman Cain arrives at a rally for U.S. Republican presidential candidate and former Speaker of the House Newt Gingrich in Tampa, Florida January 30, 2012. REUTERS/Shannon Stapleton/File Photo

“If I had to vote today, I would vote no,” Senator Kevin Cramer said in a statement.

If all of the Senate’s Democrats and the two independents aligned with them were to vote against Cain, he would fall short of the majority support he needs.

ABC News, citing sources familiar with the matter, said late on Thursday that Cain was expected to withdraw his name from consideration in the coming days. Cain declined comment on the report.

Senators Mitt Romney, Lisa Murkowski and Cory Gardner, all Republicans, have each reportedly said they would vote against Cain if he is nominated. Senate Majority Leader Mitch McConnell withheld comment on Thursday on whether he would support Cain, saying he would wait to see “who is actually nominated.”

Economists and critics have expressed concerns about loyalists of Republican Trump serving on the traditionally nonpartisan central bank.

Cain has been a public advocate of many of Trump’s policies, as has Stephen Moore, another person Trump has said he wants to nominate. Neither nomination has been formally sent to the Senate.

On Facebook earlier this week, Cain said the reason he was under attack as a nominee was because he is a conservative. Cain’s bid for president in 2012 was derailed by accusations of sexual harassment that he has repeatedly denied.

White House economic adviser Larry Kudlow said earlier on Thursday that Trump intended to proceed with his plan to name Cain to the Fed’s board of governors.

“I like Herman Cain,” Trump told reporters on Wednesday. “As to how he’s doing in the process, that I don’t know. ... Herman is a great guy and I hope he does well.”

The president nominates members to the Fed’s seven-member board of governors. He elevated Jerome Powell to chairman a year ago but has frequently criticized him for the Fed’s interest rate increases.

The nominations must be approved by the Senate. The central bank’s other top policymakers head the Fed’s 12 regional banks and are chosen by local boards of directors, not the president.

Trump has slammed the central bank’s 2018 rate hikes for thwarting economic growth and publicly pressed policymakers to change course.

Central bank independence from short-term politics is seen as important to prevent influence that could lead to runaway debt, hyperinflation and financial instability. The issue is a topic of conversation at the meetings of the International Monetary Fund and World Bank in Washington this week.

“Undermining central bank independence would be dangerous,” Tobias Adrian, director of the International Monetary Fund’s monetary and capital markets department, said in an interview on Wednesday with Bloomberg News.