WASHINGTON  Defying a veto threat from President Bush, the House of Representatives voted Thursday to prohibit waterboarding and other harsh interrogation methods used by the Central Intelligence Agency against high-level prisoners from Al Qaeda.

The 222-to-199 vote, largely along party lines, sends the legislation to the Senate, where passage is less certain. The measure, part of the intelligence authorization bill, would restrict all American interrogators to techniques included in the Army Field Manual, which prohibits the use of physical force.

In a statement this week, the White House said the president would veto the bill, as a ban on harsh interrogations “would prevent the president from taking the lawful actions necessary to protect Americans from attack in wartime.”

The vote took place as the House Intelligence Committee pressed for more information about videotapes of interrogations of two men suspected of being operatives for Al Qaeda in 2002 and the destruction of the tapes in 2005.