In a chamber packed with loud personalities, Sen. Mazie Hirono Mazie Keiko HironoManchin defends Supreme Court candidate Barrett: 'It's awful to bring in religion' Democrats shoot down talk of expanding Supreme Court Democrats unveil plan declaring racism a public health issue MORE (D-Hawaii) is not the obvious pick to be a pillar of resistance to the Trump administration.

She’s not running for president. She’s petite, generally unassuming and for years had a reputation among reporters for refusing to talk in the Capitol.

She is, in the words of her colleagues, a “workhorse.”

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But Hirono, 71, has emerged as an electrifying force for progressives as they battle with President Trump Donald John TrumpBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Romney: 'Unthinkable and unacceptable' to not commit to peaceful transition of power Two Louisville police officers shot amid Breonna Taylor grand jury protests MORE on various fronts: judicial nominations, immigration, and the feud over special counsel Robert Mueller Robert (Bob) MuellerCNN's Toobin warns McCabe is in 'perilous condition' with emboldened Trump CNN anchor rips Trump over Stone while evoking Clinton-Lynch tarmac meeting The Hill's 12:30 Report: New Hampshire fallout MORE’s probe and subsequent report.

“Trump is a major motivation to be speaking out because I so disagree with some of the things that he decides on, and you notice there’s a lawsuit on just about everything he does? My gosh,” Hirono told The Hill.

She captured headlines Wednesday during Attorney General William Barr Bill BarrHarris faces pivotal moment with Supreme Court battle Hillicon Valley: DOJ proposes tech liability shield reform to Congress | Treasury sanctions individuals, groups tied to Russian malign influence activities | House Republican introduces bill to set standards for self-driving cars McCarthy threatens motion to oust Pelosi if she moves forward with impeachment MORE’s hearing before the Judiciary Committee, which has three Democrats running for president, when she used a blistering four-minute monologue to accuse him of lying to Congress and to tell him to resign.

“Now the American people know that you are no different from Rudy Giuliani Rudy GiulianiThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting CIA found Putin 'probably directing' campaign against Biden: report Democrats fear Russia interference could spoil bid to retake Senate MORE or Kellyanne Conway Kellyanne Elizabeth ConwaySpecial counsel investigating DeVos for potential Hatch Act violation: report George and Kellyanne Conway honor Ginsburg Trump carries on with rally, unaware of Ginsburg's death MORE or any of the other people who sacrifice their once decent reputation for the grifter and liar who sits in the Oval Office,” Hirono said.

The exchange marked one of the most aggressive moments of the hearing, and it underscored Hirono’s role as one of the caucus’s staunchest Trump critics and her penchant for making high-profile, viral moments that thrill progressives.

It’s also made her a target for Republicans, who have nicknamed her “Crazy Mazie.”

White House press secretary Sarah Huckabee Sarah Elizabeth SandersSarah Sanders on Trump's reported war dead criticism: 'Those comments didn't happen' Sarah Sanders memoir reportedly says Trump joked she should hook up with Kim Jong Un McEnany stamps her brand on White House press operation MORE Sanders said Democrats “embarrassed” themselves during the hearing with Barr and called Hirono’s questions “unbelievable.”

Josh Holmes, a former chief of staff and longtime adviser to Senate Majority Leader Mitch McConnell Addison (Mitch) Mitchell McConnellFEC flags McConnell campaign over suspected accounting errors Poll: 59 percent think president elected in November should name next Supreme Court justice Mark Kelly: Arizona Senate race winner should be sworn in 'promptly' MORE (R-Ky.), called her “an embarrassment.”

And Senate Judiciary Committee Chairman Lindsey Graham Lindsey Olin GrahamSenate GOP aims to confirm Trump court pick by Oct. 29: report The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Senate GOP sees early Supreme Court vote as political booster shot MORE (R-S.C.) interrupted Hirono’s back-and-forth with Barr and accused her of slandering Trump’s attorney general “from top to bottom.”

Hirono laughed when asked by The Hill about Graham’s comment as well as the accusation from GOP senators that Democrats gave Barr the “Kavanaugh treatment.”

“What is the Kavanaugh treatment except to ask very specific questions or to make very specific statements?” she asked. “The defense to slander is the truth, and sometimes the truth hurts. Opinion is not slander.”

Hirono also stood by her criticism of Barr and urged Democrats to keep raising concerns about Trump’s attorney general and the White House, referring to it as a “moral dead zone.”

“Everybody who gets into that dead zone suddenly becomes sycophants. They don’t seem to care about the rule of law, and all they care about is being yes people for the president,” Hirono added.

It’s not the first time Hirono’s criticism of the Trump administration has gone viral, a skill that has made her an unexpected favorite of the left.

She catapulted into the spotlight during the months-long battle over Brett Kavanaugh Brett Michael KavanaughHarris faces pivotal moment with Supreme Court battle Poll: 59 percent think president elected in November should name next Supreme Court justice Feinstein 'surprised and taken aback' by suggestion she's not up for Supreme Court fight MORE’s Supreme Court nomination, where she was one of four women on the Judiciary Committee at a time when there were no female GOP senators on the panel.

Hirono asked Kavanaugh during his confirmation hearing if he “ever made unwanted requests for sexual favors or committed any verbal or physical harassment or assault of a sexual nature” as a legal adult.

Kavanaugh said he had not, but the exchange resurfaced months later amid the allegations from Christine Blasey Ford that Kavanaugh sexually assaulted her at a party when they were both minors. Kavanaugh denied any wrongdoing.

Hirono also broke with her typically restrained demeanor roughly a week before Ford and Kavanaugh both testified, when she said men need to “shut up and step up” in the wake of the sexual assault allegations.

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Hirono has emerged as a favorite for progressive groups in large part because of her staunch opposition to Trump’s judicial nominees. She has pledged to vote against advancing all court picks, objecting to how Senate Republicans are processing nominations, a key priority for McConnell.

“Now that there’s only two hours of debate time, the Republicans are doing everything they can to clear the decks for as many nominees … to get confirmed as soon as possible, mainly on partisan lines,” she said. “I feel very strongly about this, as you can tell.”

The tactics earned her the title of “badass” from Demand Justice. The progressive group also gave her an A and its top spot among the Democratic caucus in a report card released earlier this year grading senators’ willingness to oppose Trump’s nominees.

Some of the floor fights have been deeply personal for Hirono, particularly during the 2017 ObamaCare repeal effort by Republicans.

Hirono delivered a speech from the floor in June 2017 in which she discussed her health battles after announcing a kidney cancer diagnosis a few months earlier. Hirono also appeared to hold back tears as she discussed her fears as an immigrant that her mother would fall ill and the death of her sister when she was a child in Japan.

Hirono is one of two Asian Americans in the Senate and the chamber’s only immigrant. She moved from Japan to Hawaii when she was seven years old and got her citizenship in 1959 when Hawaii became a state.

And while viral moments have earned her national attention, Hirono's colleagues also credit her with digging into unglamorous issues such as patents.

Sen. Christopher Coons Christopher (Chris) Andrew CoonsMurkowski: Supreme Court nominee should not be taken up before election Battle lines drawn on precedent in Supreme Court fight Sunday shows - Ruth Bader Ginsburg's death dominates MORE (D-Del.), who serves with Hirono on the Judiciary Committee, said she has been “so wonderfully persistent and engaged.”

“She's not just a show horse. She's a workhorse. And Sen. Hirono is someone who digs into the details, does her homework and knows what she is talking about on arcane subjects … as well as more high-profile hearings,” Coons added.

Hirono points to disagreements with Trump as a factor for pushing her to embrace the media spotlight as a way to voice her opposition to the administration’s policies.

“There’s also a recognition that we do have to speak out, to push back against this administration. So I began to do more of that,” she said. “It’s been a journey because not all of us just kind of pop out and start popping off. ... You don’t see too many Asian people out there, Asian women.”

But she doesn’t limit her criticism to Republicans. Hirono was the second female senator to call on former Sen. Al Franken Alan (Al) Stuart FrankenGOP Senate candidate says Trump, Republicans will surprise in Minnesota Peterson faces fight of his career in deep-red Minnesota district Getting tight — the psychology of cancel culture MORE (D-Minn.) to resign over sexual misconduct allegations. And amid accusations of inappropriate touching by former Vice President Joe Biden Joe BidenBiden on Trump's refusal to commit to peaceful transfer of power: 'What country are we in?' Democratic groups using Bloomberg money to launch M in Spanish language ads in Florida Harris faces pivotal moment with Supreme Court battle MORE, she’s publicly urged him to recognize that his behavior has made some women uncomfortable and to change it.

“Women are socialized to be very nice and put up with a lot of things,” she told reporters last month. “I know that Joe Biden is not a sexual harasser. ... This kind of behavior is a habit. If someone points out that you have a habit, you can change it.”

As Hirono continued to speak with reporters in the Senate basement, Sen. John Kennedy John Neely KennedyMORE (R-La.) interrupted by putting his hands on two reporters’ shoulders and jokingly telling the group to “leave her alone, for God's sake. She’s just minding her own business. She’s a good person.”

As Kennedy quipped that she didn’t have to talk to reporters, Hirono sent him away by reassuring him that she was fine.

“I want to talk to these guys,” she added. “I’m totally free to defend myself. Thank you so much.”

Jacqueline Thomsen contributed.