Israeli leaders said Monday that Palestinian President Mahmoud Abbas had “lost his senses” after his harsh attack on President Trump and remark that the US role as a mediator in the volatile region was finished.

In a 2½-hour speech, the Palestinian leader sharply escalated his rhetoric, lashing out at the US, Israel, Britain and even other Arab leaders, whom he told to “go to hell” for criticizing him.

He pronounced the peace process dead, and blamed Israel for killing it.

The Sunday night speech came at a tough time for the 82-year-old Abbas, who after 13 years in power has made little progress toward his goal of establishing an independent Palestinian state on lands captured by Israel in the 1967 war.

Hamas militants now control the Gaza Strip, his erstwhile Arab allies have quietly moved closer to Israel or turned their attention to other pressing matters such as Iran, and he has lost faith in the US as a Mideast broker following Trump’s recognition of Jerusalem as Israel’s capital last month.

Abbas also is deeply unpopular with his own public.

In the address, Abbas attacked Trump over the Jerusalem decision and rebuked Trump’s recent Twitter comment threatening to cut American aid and alleging the Palestinians were no longer willing to negotiate a peace deal.

“Since when did we reject negotiations?” Abbas told members of the Palestinian Central Council, a key decision-making body. “Shame,” Abbas said, addressing Trump.

To laughter from the crowd, Abbas then added the phrase “Yekhreb Beitak,” literally translated as “May your house be demolished.”

In colloquial Palestinian Arabic, the phrase can have different connotations, from a harsh to a casual insult, but its use in a widely watched speech seemed jarring — and could exacerbate his already fragile relationship with the notoriously thin-skinned American president.

Abbas called Trump’s moves a “slap in the face” and threatened that the Palestinians “will slap back,” without elaborating. He took particular aim at the US ambassador to Israel, David Friedman, a strong supporter of Israel’s West Bank settlements, for reportedly objecting to the use of the word occupation, and Nikki Haley, the US ambassador to the UN, for once quipping that she wore high heels to fend off Israel’s opponents.

“He [Friedman] is an offensive human being, and I will not agree to meet with him anywhere. They requested that I meet him and I refused,” he said.

“Nikki Haley too. She threatens to hit people who hurt Israel with the heel of her shoe, and the response to her speech will be harsher.”

A day later, Israeli Defense Minister Avigdor Lieberman said Abbas had “lost his senses” and had given up on the prospect of peace negotiations in favor of open confrontation with both Israel and the US.

Israeli Education Minister Naftali Bennett, head of the pro-settler Jewish Home Party, said the speech represented Abbas’ swan song.

Prime Minister Benjamin Netanyahu, during a trip to India, said Abbas “tore off the mask” and had exposed what he called the truth.

“The root of the conflict between us and the Palestinians is their continuous refusal to recognize the Jewish state in any borders,” he said in a statement on Facebook.

Abbas also reiterated his demand that Britain apologize for its 1917 Balfour Declaration, which endorsed the idea of a Jewish state.

He accused Israel of sending drugs to Palestinian children.

Most angering to Israelis, however, was his assertion that the country was a result of Western efforts to offload their Jews.

“They wanted to bring Jews here from Europe to maintain European interests in the region. They asked Holland, which had the largest navy in the world, to transfer the Jews,” he said. “Israel is a colonialist project that has nothing to do with Jews.”

Given the lack of actual policy decisions, the speech appeared to reflect frustration over prolonged deadlock and a sense of abandonment.

“It is a necessary bravado for his own people having come short in the diplomatic process,” said Uri Savir, an Israeli who negotiated with Abbas in the early 1990s.

“Rhetoric aside, I know him as a moderate, but there is a dangerous air of desperation in Ramallah that Israel better take seriously and try to find ways to engage in diplomatic talk on a two-state solution.”

Trump put his son-in-law, Jared Kushner — a 37-year-old with no political or policy experience — in charge of bringing peace to the Middle East, a move that has yet to bear any tangible fruit.

With Post wires