NY/NJ SAS Territory:

New York: East of and including St. Lawrence, Herkimer, Otsego, and Delaware Counties

New Jersey: North of and including Hunterdon, Somerset, Middlesex and Monmouth Counties.

Connecticut: Fairfield County





Corronavirus Update

To all of our friends and their family members: We hope you are all staying healthy, and doing well during this stressful time. We have postponed our live meetings until the country gets back to a normal work schedule. In the interim, we are working to develop an on-line meeting schedule so that we can stay connected. Best wishes for good health and be safe!





Welcome Back! Next NY/NJ SAS Meeting is THURSDAY, Sept. 24th

Date: Thursday, Sept 24th, 2020 Time: 11:45am login begins. Start: 12:00am-1:00pm EST Cost: FREE On-Line Microsoft Teams We will live stream the presentation: RSVP for Webinar to john.wasylyk@bms.com and we will send you a link to the Webinar.

Location: On-line Meeting Agenda: 11:45 am Log-in 12:00 am - Welcome, introduction & announcements 12:05 -1:00 pm - Presentation by Dr. William Querido

Title: Applications of Infrared Spectroscopy and Imaging to Investigate Bone and Cartilage

Speaker: Dr. William Querido is currently a Postdoctoral Researcher and Adjunct Assistant Professor at Temple University Abstract: Infrared spectroscopy and imaging has greatly advanced our understanding of biological tissues in normal, pathological and therapeutic conditions. In this presentation, I will focus on recent examples of the application of different modalities of this method for the investigation of skeletal tissues, focusing on bone and cartilage. In particular, I will present on original findings obtained using mid infrared (MIR), near infrared (NIR) and optical photothermal infrared (O-PTIR) spectroscopy and imaging. I will discuss examples of different applications, such as (1) the use of MIR to gain new insights into the pathway of bone development, providing direct evidence of an amorphous mineral precursor in early bone mineralization; (2) the use of NIR coupled to a fiber optic probe for the nondestructive assessment of tissue engineered cartilage while growing in vitro, providing an approach to potentially select optimal constructs before implantation in cartilage defects; (3) the promising clinical application of NIR for assessing bone quality in patients in need of an non-ionizing alternative to X-ray exams, (4) the use of NIR to evaluate bone water content and distribution within the tissues, and (5) the use of the novel O-PTIR modality to evaluate cortical and trabecular bone structures with sub-micron spatial resolution. My expectation for this presentation is to show in a few examples how infrared spectroscopy and imaging can provide rich and valuable insights into properties of skeletal tissues. Author’s Bio: Dr. William Querido is currently a Postdoctoral Researcher and Adjunct Assistant Professor at Temple University. He has two PhD degrees, in Biological Sciences (Biophysics) (Brazil) and Cell Biology (France), and enjoys employing multidisciplinary approaches and perspectives to gain insights into skeletal tissue biology, as well as to advance research towards improving assessment and treatment of diseases and lesions. Since 2017, he has worked with Dr. Nancy Pleshko on applications of different modalities of infrared spectroscopy and imaging to investigate properties of the extracellular matrix of bone and cartilage in vitro, ex vivo and in vivo.

Looking Ahead: October meeting is scheduled for Thursday October 22, 2020

Title: Optimizing Industrial Classification and Regression Applications with Absorbance-Transmittance Excitation-Emission Matrix (A-TEEM) Spectroscopy using Multi-Block Modeling and Extreme Gradient Boosting.



Speaker: Dr. Adam Gilmore, Fluorescence Product Manager at HORIBA Instruments

Abstract:

This presentation explains how industrial process monitoring and quality control applications can be greatly facilitated by the rapid, reagent-free, purely optical A-TEEM method for discrimination and quantification of a sample’s molecular composition. This presentation is centered on a few key application examples including: 1) wine phenolics and anthocyanins, 2) cannabinoids, 3) water-soluble aromatic petroleum compounds and 4) bioreactor cell-media components. A-TEEM spectroscopy is already well recognized for its capacity to decompose mixtures based on their unique fluorescence excitation-emission spectral properties over a wide concentration range (from ppm to sub-ppb levels). However, in this paper we focus on how we can further advance the analytical precision, accuracy and concentration range of the A-TEEM method. Firstly, we demonstrate using well-defined calibration and independent test sets that using a multi-bock approach, where the absorbance and EEM spectral variables are analyzed simultaneously, significantly improves discrimination and regression accuracy. This is primarily because each compound in solution has both a unique absorbance molar extinction coefficient and fluorescence quantum yield in addition to unique absorbance/excitation and fluorescence emission spectral shape properties. Further, in many cases different classes of compounds in a mixed solution exhibit widely varying levels of colored and fluorescent optical activity. In addition, the study shows that we realize a significant systematic improvement of the discrimination and regression accuracy by using the Extreme Gradient Boost (XGB) decision-tree algorithm in the Eigenvector Inc. Solo software package; noting this general improvement is observed in direct comparisons to Partial Least Squares, Principal Components and Support Vector Machine algorithms. The presentation concludes by showing how industrial discrimination and regression applications are facilitated by automating our software interface for multi-block modeling and XGB algorithm implementation.

On-Line: We will live stream the presentation: Click here for Meeting link:

Time: 11:55-1:05pm EST

Bio of Speaker:

Dr. Adam Gilmore is a Fluorescence Product Manager at HORIBA Instruments Inc. He received his Ph.D. in 1992 from the University of Hawaii at Manoa in the Department of Plant Molecular Physiology. His Dissertation centered on the first simultaneous absorbance and fluorescence measurements to define a causal relationship between xanthophyll-cycle carotenoids and photoprotective nonradiative dissipation of excess energy in Photosystem II, measured by chlorophyll fluorescence. He pursued the physiological significance of this subject during his first postdoctoral tenure at the Carnegie Institution of Washington’s Department of Plant Biology and its biophysical mechanism during his second postdoctoral tenure at the University of Illinois at Urbana Champaign’s Laboratory for Fluorescence Dynamics. He worked for 7 years at the Australian National University as a Research Fellow and Fellow followed by a one year sabbatical at UC Berkeley’s LNL before joining HORIBA in 2004. At HORIBA he has developed and patented application-specific instruments and software methods with primary foci on nanotechnology and water treatment monitoring applications. The most significant developments have included simultaneous absorbance-fluorescence instruments utilizing multichannel detectors.

For more meeting information CLICK HERE

2020 NYSAS Gold Medal Award - Jerry Workman & Howard Mark! Congratulations





For more information on Gold Medal Winners Click HERE

The award will be presented at the Eastern Analytical Symposium (November 18-20, 2019 Princeton, NJ) meeting on Tuesday Nov. 19th 8:30am-11:30am. We hope to see our members attend this prestigious award session. Website: www.easinc.org Gold Medal Award Session Symposium Speakers:





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