Aretha Franklin, the undisputed "Queen of Soul" who sang with matchless style on such classics as "Think," ''I Say a Little Prayer" and her signature song, "Respect," and stood as a cultural icon around the globe, has died at age 76 from advanced pancreatic cancer. Publicist Gwendolyn Quinn tells The Associated Press through a family statement that Franklin died Thursday at 9:50 a.m. at her home in Detroit. The statement said "Franklin's official cause of death was due to advance pancreatic cancer of the neuroendocrine type, which was confirmed by Franklin's oncologist, Dr. Philip Phillips of Karmanos Cancer Institute" in Detroit.

The family added: "In one of the darkest moments of our lives, we are not able to find the appropriate words to express the pain in our heart. We have lost the matriarch and rock of our family. The love she had for her children, grandchildren, nieces, nephews, and cousins knew no bounds." The statement continued: "We have been deeply touched by the incredible outpouring of love and support we have received from close friends, supporters and fans all around the world. Thank you for your compassion and prayers. We have felt your love for Aretha and it brings us comfort to know that her legacy will live on. As we grieve, we ask that you respect our privacy during this difficult time."

Artists and celebrities around the world paid their respects on Twitter:

Aretha Franklin performs on stage in 1970 in the United States. (Photo by Gilles Petard/Redferns) Gilles Petard | Redferns | Getty Images

Despite growing up in Detroit, and having Smokey Robinson as a childhood friend, Franklin never recorded for Motown Records; stints with Columbia and Arista were sandwiched around her prime years with Atlantic Records. But it was at Detroit's New Bethel Baptist Church, where her father was pastor, that Franklin learned the gospel fundamentals that would make her a soul institution. Aretha Louise Franklin was born March 25, 1942, in Memphis, Tennessee. The Rev. C.L. Franklin soon moved his family to Buffalo, New York, then to Detroit, where the Franklins settled after the marriage of Aretha's parents collapsed and her mother (and reputed sound-alike) Barbara returned to Buffalo. C.L. Franklin was among the most prominent Baptist ministers of his time. He recorded dozens of albums of sermons and music and knew such gospel stars as Marion Williams and Clara Ward, who mentored Aretha and her sisters Carolyn and Erma. (Both sisters sang on Aretha's records, and Carolyn also wrote "Ain't No Way" and other songs for Aretha). Music was the family business and performers from Sam Cooke to Lou Rawls were guests at the Franklin house. In the living room, the shy young Aretha awed friends with her playing on the grand piano. Franklin occasionally performed at New Bethel Baptist throughout her career; her 1987 gospel album "One Lord One Faith One Baptism" was recorded live at the church. Her most acclaimed gospel recording came in 1972 with the Grammy-winning album "Amazing Grace," which was recorded live at New Temple Missionary Baptist Church in South Central Los Angeles and featured gospel legend James Cleveland, along with her own father (Mick Jagger was one of the celebrities in the audience). It became one of of the best-selling gospel albums ever.

Aretha Franklin performs on stage at the Park West Auditorium, Chicago, Illinois, March 23, 1992. Paul Natkin | Archive Photos | Getty Images