A female cyclist has been killed in a crash involving a truck in Melbourne's south-east, police say.

It happened at the intersection of St Kilda St and North Rd in Brighton about 10:00am.

The cyclist died at the scene. She is yet to be identified.

The male truck driver is helping investigators with their inquiries, police said.

St Kilda St in Brighton leads onto Beach Rd, a popular route for cyclists on long rides or group rides, not just daily commuters.

The cyclist has yet to be identified. ( ABC News: Patrick Rocca )

Earlier this year, a cyclist was hit and killed by a truck in Yarraville, in Melbourne's inner west, leading to calls to improve bike lanes and signage.

The Greens said there needed to be better separation between cyclists and traffic, and more designated bike routes.

There were similar calls in 2015 after a cyclist was killed when a car door opened and knocked him into the path of a truck on Sydney Rd.