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According to its ESRB (Entertainment Software Ratings Board) rating, Resident Evil 6

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The ESRB's description of the mature content reads: "One female boss character (a human-spider hybrid) is depicted nude—though without any discernible details (i.e., no nipples or genitalia); during one attack move, she briefly caresses her breasts while straddling on players' character."Fans of the series may remember similar monster nudity in Codename Veronica, but the ESRB does not recognize that instance.Resident Evil 6 is set to be released on October 2. Check out our impressions of the most recent demo from Comic-Con here: