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What are stem cells and how can stem cells treat hearing loss? What’s going on with human trials for hearing regeneration? When can we expected new treatments on the market? And will regenerating hearing resolve tinnitus? These kinds of questions will be answered in this podcast!

Tinnitus Talk spoke with Marcelo Rivolta, professor of Sensory Stem Cell Biology at the University of Sheffield. He explains the basic concepts of stem cells and the different approaches to hearing regeneration. It’s fascinating science, but there are a number of roadblocks to be cleared before patients can benefit.

Marcelo also announces that he received a research grant and used it to start a biotechnology company called Rinri. If you want to stay up to date with the progress of Rinri, please visit their website.

The interview with Marcelo was conducted by Steve Harrison (Tinnitus Talk) and David Stockdale (British Tinnitus Association). As added bonus material at the end, Hazel and Markku discuss the Tinnitus Talk Podcast ‘behind the scenes.’

Skip to: 00:00 Introduction to Stem Cells.

We need to show that the cells themselves are safe […] that they will not produce tumours.

Skip to: 07:20 Targeting the Correct Area with Stem Cells.

Skip to: 11:41 Types of Hearing Loss, and How Much Can be Recovered.

Neuropathic deafness is probably a better candidate because the nerve is more accessible […] The hair cell remains the main target, but it is still very, very challenging to get there.

Skip to: 17:05 From Animal to Human Models.

Skip to: 19:17 How can Stem Cells Treat Hearing Loss?

Induced pluripotent stem cells are very attractive, because the cells can be taken from the same patient […] you can generate the specific cell type for the ear […] and then you transplant them and use that as a therapy.

Skip to: 21:46 Ongoing Clinical Trials.

Skip to: 24:21 Success Factors for Hearing Restoration.

Skip to: 28:57 Experimental Treatments: Platelet Rich Plasma Injections.

Skip to: 31:32 Will Hearing Regeneration Resolve Tinnitus?

Steve: Do you believe that regenerating hearing will actually resolve tinnitus?

Marcelo: Probably yes, it will have a very positive impact.

Skip to: 33:06 Getting to Market.

Skip to: 42:03 Behind the Scenes with Markku and Hazel