Another 49ers coach, another home opener. Kyle Shanahan’s debut as 49ers coach reportedly will come at Levi’s Stadium, just not on the same “Monday Night Football” stage his predecessors enjoyed the previous two seasons.

The 49ers will open by hosting the Carolina Panthers on Sunday, Sept. 10. The 49ers’ last two seasons began with “Monday Night Football” routs, home victories over Minnesota (20-3) and the Los Angeles Rams (28-0) that inspired false hope of a turnaround under coaches Jim Tomsula and Chip Kelly.

What happens after Week 1 for Shanahan’s crew is a travel-heavy schedule the first half of the season, including three consecutive road games: at the Arizona Cardinals, Indianapolis Colts and Washington.

“You’re talking a tough way to start for a new coaching staff and new GM,” former 49ers coach Steve Mariucci said on NFL Network.

Before that stretch, the 49ers’ first road game will come in Week 2 at division rival Seattle. That trek is not as logistically challenging as the Week 2 games encountered by Tomsula and Kelly. Those coaches followed each opener with an East Coast trip against a team coming off 10 days of rest; the 49ers lost 43-18 at Pittsburgh in 2015 and 46-27 at Carolina last year.

In 2013, the 49ers visited Seattle in Week 2, losing 29-3 after opening their last playoff season with a home win over Green Bay.

After facing the Seahawks, the 49ers return home for a quick turnaround and their only prime-time game, against the Rams on Thursday night, Sept. 21. Then comes a three-game, three-city spree last forced upon the franchise in 2005, when they played December road games at Seattle, Jacksonville and St. Louis.

Conceivably, the 49ers could break up that three-game stretch with a layover in Youngstown, Ohio between their games at Indianapolis and Washington. The 49ers stayed there during Jim Harbaugh first two seasons as coach in 2011 and ’12, and a return likely will be Shanahan’s call.

The 49ers have five road games with 10 a.m. PT starts: at Indianapolis (Oct. 8), Washington (Oct. 15), Philadelphia (Oct. 29), Chicago (Dec. 3) and Houston (Dec. 10).

Here is a game-by-game preview:

Sept. 10 vs. Carolina Panthers (1:25 p.m., Fox): Cam Newton and Co. return to the site of their Super Bowl 50 defeat, and the Panthers open on the road for the sixth time in coach Ron Rivera’s seven seasons. are the last franchise the 49ers beat in the playoffs (January 2014), but Carolina avenged that loss by routing the 49ers 46-27 last season in Week 2.

Sept. 17 at Seattle Seahawks (1:25 p.m., Fox): The 49ers’ last won in Seattle when Jim Harbaugh was a first-year NFL coach, in 2011. Since then, the losses have been by 29, 26, six, 10, 16 and 19 points.

Sept. 21 vs. Los Angeles Rams (5:25 p.m., NFLN): A prime-time, Thursday night game is bestowed upon the 49ers, who may have only won two games last season but went 2-0 against their recycled in-state rival. Jared Goff, welcome home.

Oct. 1 at Arizona Cardinals (1:05 p.m., Fox): Last year’s visit resulted in an eighth straight defeat, and that loss came on a last-second field goal, shortly after Colin Kaepernick ran for a tying touchdown.

Oct. 8 at Indianapolis Colts (10 a.m., Fox): That No. 21 in a Colts uniform should look familiar to 49ers fans: Frank Gore, in his 13th season. The 49ers’ last trip here was 2009, and before that it was the 2001 visit that incited Jim Mora to say: “Playoffs?! Don’t talk about playoffs. You kidding me? Playoffs?”

Oct. 15 at Washington (10 a.m., Fox): Quarterback Kirk Cousins, pending the absence of a long-term deal, will audition in front of possibly his next employer. Of course, Washington was once Kyle Shanahan’s employer, too, and this is his first game back since leaving town with his father after the 2013 season.

Oct. 22 vs. Dallas Cowboys (1:05 p.m., Fox): The 49ers’ 2016 fate took a drastic turn for the worse when the Cowboys rallied for a Week 4 win at Levi’s Stadium once NaVorro Bowman tore his Achilles.

Oct. 29 at Philadelphia Eagles (10 a.m., Fox): Torrey Smith totaled just seven touchdowns and 53 receptions the past two seasons before the 49ers released him and the Eagles promptly signed him. This is the 49ers’ first visit since a 2011 win that established them as a legitimate contender.

Nov. 5 vs. Arizona Cardinals (1:05 p.m., Fox): The 49ers lost 19-13 and 33-21 the last two seasons at home against the Cardinals. That’s no way to regain NFC West supremacy.

Nov. 12 vs. New York Giants (1:25 p.m., Fox): After so many storied meetings at the 49ers’ old homes of Kezar Stadium and Candlestick Park, the Giants make their Levi’s Stadium debut, bringing along former 49ers running back Shaun Draughn.

Nov. 19: Bye

Nov. 26 vs. Seattle Seahawks (1:05 p.m., Fox): Who’s benefited most from Levi’s Stadium — other than the 49ers owners bank accounts? Pete Carroll went 0-4 as the Seahawks coach in visits to Candlestick Park, but he’s 3-0 at Levi’s Stadium.

Dec. 3 at Chicago Bears (10 a.m., Fox): Soldier Field for a third straight year? Sure, but will it be as invigorating for the 49ers as their 2015 overtime win or as embarrassing as last year’s 26-6 loss (6 net passing yards)?

Dec. 10 at Houston Texans (10 a.m., Fox): Which quarterback will the 49ers face in only their second-ever regular-season visit? Tom Savage? Brandon Weeden? Or a rookie draft pick, or current Patriots asset Jimmy Garoppolo?

Dec. 17 vs. Tennessee Titans (1:25 p.m., CBS): The 49ers were too gracious of hosts and lost 34-27 in 2009 when the Titans last visited.

Dec. 24 vs. Jacksonville Jaguars (1:05 p.m., CBS): These teams last met in London midway through the 2013 season, as coach Jim Harbaugh’s 49ers won 42-10 for that season’s most lopsided win.

Dec. 31 at Los Angeles Rams (1:25 p.m., FOX): Colin Kaepernick’s greatest and last comeback for the 49ers came here on Christmas Eve. It’s also where Carlos Hyde suffered a devastating knee injury trying to catch a Kaepernick pass.

Kyle Shanahan gets traditional Week 1 home debut for new #49ers coaches (not MNF) before brutal road sked, 5 10am starts, 1 prime-time game pic.twitter.com/T2Hb2jdCQg — Cam Inman (@CamInman) April 21, 2017

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Exhibitions:

Aug. 11 at Kansas City Chiefs (8 p.m., Ch. 5)

Aug. 19 vs. Denver Broncos (7 p.m., Ch. 5)

Aug. 27 at Minnesota Vikings (5 p.m., NBC)

Aug. 31 vs. Los Angeles Chargers (7 p.m., Ch. 5)