The chief executive of an Ohio health care system announced his resignation and the termination of 23 employees on Thursday, one month after a doctor who worked for the hospital was charged in one of the largest murder cases in the state’s history.

Ed Lamb, the chief executive of Mount Carmel Health System, said in a statement that his resignation would take effect on July 25. He added that the hospital’s executive vice president, Richard Streck, would be retiring at the end of September. The employees’ terminations were effective immediately.

“Mount Carmel will continue to work on strengthening our culture of safety,” Mr. Lamb said in the statement. “It will take time for Mount Carmel to restore our patients’ and community’s trust.”

Eleven additional employees not included in the terminations will have the opportunity to return after additional training, Mr. Lamb said. Trinity Health, the hospital’s parent organization , will soon appoint an interim chief, he added. Mount Carmel describes itself as the second-largest health care system in central Ohio.