Mirko Filipovic is out of this month’s UFC Fight Night 79 co-headliner. He’s also apparently done with the sport.

After past retirements from both MMA and kickboxing, the 41-year-old eventually found his way back to competition. This time, though, “Cro Cop” (31-11-2 MMA, 5-6 UFC) said a shoulder injury has forced him out of his fight with fellow heavyweight Anthony Hamilton (14-4 MMA, 2-2 UFC) and that it prompted him to retire from all competition.

UFC officials haven’t made a formal announcement, and it’s not clear if a replacement will be sought on short notice.

UFC Fight Night 79 takes place Nov. 28 at Olympic Gymnastics Arena in Seoul. The entire event streams on UFC Fight Pass.

“Unfortunately I had to cancel the fight in Seoul,” the Croatian fighter wrote on his website, mirkofilipovic.com. “In the beginning of the preparation I already hurt my shoulder, so I couldn’t raise a hand. I tried to save a shoulder injury and repair in all possible ways: daily therapy, injections of blood plasma and various cocktails of drugs but didn’t work out. The only cure would be a break of two to three weeks, and that I could not afford in the midst of final preparations. By daily trainings the injury gets worse. Part of the muscle is snapped, the shoulder is filled with a lot of fluids, and the great danger is that tendon ruptures and then go to operation again.”

“Cro Cop,” a former PRIDE star, made a long-awaited UFC debut in 2007 but went 1-2 and made a quick departure. He then returned in 2009 and went 3-4 and announced his retirement, but it was short-lived, and he returned to kickboxing and then MMA. In April, he joined the UFC for a third stint and earned a “Fight of the Night” bonus for his TKO win over Gabriel Gonzaga. It then led to the booking against Hamilton.

However, injuries – a constant nuisance in the second half of his career – again became an issue.

“I am aware that I have come to the end of my martial times, but training with pain I want no longer,” he said. “My body is battered by countless trainings. I collected nine operations. The body has become prone to injury. After each workout I put ice on my knee operated on because it’s filled with fluid, therapies twice a week. The next fight would be 80th professional, and that is a lot, especially in the competition: K-1, Pride, IGF, UFC.”

The latest UFC Fight Night 79 card includes:

MAIN CARD (UFC Fight Pass, 8 a.m. ET)

Thiago Alves vs. Benson Henderson Anthony Hamilton vs. TBA Dong Hyun Kim vs. Jorge Masvidal Yoshihiro Akiyama vs. Alberto Mina

PRELIMINARY CARD (UFC Fight Pass, 4:45 a.m. ET)

Hyun Gyu Lim vs. Dominique Steele Doo Ho Choi vs. Sam Sicilia Yui Chul Nam vs. Mike De La Torre Tae Hyun Bang vs. Leo Kuntz Jake Collier vs. Dongi Yang Fredy Serrano vs. Yao Zhikui Marco Beltran vs. Ning Guangyou Cortney Casey vs. Seo Hee Ham

For more on UFC Fight Night 79, check out the UFC Rumors section of the site.