How the 4th era of technology innovations is fusing physical , digital and biological domains such as 3D printing of human organs, micro and nano engineering of materials; genes engineering to robotics in vehicles and mixed reality. These are in turn changing skills, human experiences, jibs, productivity and how things work and get work gets done. It is s[reading across industries and creating a new range of cross-cutting concerns that include massive internet-working effects; resources and water supply challenges, cyber security and ethics, machines and societal questions.