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SOMEONE DRUGGED JOHNNY KNOXVILLE AT A FRAT HOUSE ... so says Johnny Knoxville, but he ain't exactly complaining about it.

Knoxville says someone slipped an ecstacy pill into his beer during a recent promo shoot for his new movie "Bad Grandpa" ... and during his drug-induced haze, he injured his hand.

"I wasn't mad at all," Johnny said ... "I hadn't done it since my 20s and I was like 'this is awesome' ... and after that the wheels fell off." "I wasn't mad at all," Johnny said ... "I hadn't done it since my 20s and I was like 'this is awesome' ... and after that the wheels fell off."