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Samantha Markle, 53, is calling on her sister to help legalise marijuana for medicinal purposes, Daily Star Online can reveal.

The sister says Meghan would be “foolish” not do so - despite it being a Class B drug - and that it is “in her best interest”,

Samantha’s stunning request comes just weeks after Meghan - now the Duchess of Sussex - wed Prince Harry in a £32million Royal Wedding.

She was not invited though, and having planned to fly to London from her Florida home uninvited, she changed her mind after admitting she had several “fears”.

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But now she is reaching her hand out to Meghan to help thousands of suffering Brits who believe medicinal cannabis can cure pain.

Samantha, who suffers from spinal multiple sclerosis and is wheelchair-bound, says she is a “huge advocate” of medical marijuana.

She said she backs the drug “for its anti-inflammatory and therapeutic benefits for people living with multiple sclerosis”.

The sister, who shares she same dad as Meghan, told Daily Star Online: “That is greatly needed in the UK.

(Image: GETTY)

“In my opinion she (Meghan) should advocate for the use of medical marijuana to alleviate the suffering from a wide variety of conditions but specifically MS because of its prevalence in the uk.

“It would be foolish for her not to advocate for it because MS is known as a genetic condition it lives on the same genetic locus as rheumatoid arthritis.

“…it would be in her best interest to advance MS research and treatment.

“Medical marijuana has been statistically and scientifically shown to have therapeutic and healing benefits - the information is salient.”

(Image: GETTY)

Samantha told how she believes advocating this could even bolster Meghan’s already booming popularity with Brits.

She said: “I feel that it would greatly benefit the UK to push for progress and research and treatment given the high prevalence of MS there.

“It would be an exciting opportunity and wonderful for Meghan to consider a platform that improves the lives of so many around the world but particularly in the UK who live with MS.”