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House Speaker Paul Ryan tapes an interview with Bill Hemmer, co-anchor of Fox News Channel's "America's Newsroom," in New York, Monday, April 25. | AP Photo Ryan: Trump 'comfortable' with my vision for GOP

House Speaker Paul Ryan downplayed any conflict between his detailed policy proposals and those pushed by Donald Trump on Wednesday, hours after the front-runner sewed up five more states and marched ever closer to locking up his party’s nomination.

"The key for populism, Joe, as you well know because you practiced this, how do you take this populism and connect it to principle so that it’s populism tethered to good principles which give us good solutions, not unprincipled populism and that to me is our value added to this equation," the Wisconsin Republican said in a segment on MSNBC's "Morning Joe" Wednesday, referring to co-host Joe Scarborough's time as a lawmaker representing Florida.

Though he did not mention Trump by name and has been magnanimous even in his policy criticisms of Trump in the past, Ryan signaled that no matter Republicans' standard bearer in November, the party will be "comfortable" and unify around the platform that he is advocating in Congress.

He also described any differences with Trump and other candidates over Obamacare and tax reform as small obstacles, remarking that they share broader agreement on the issues.

"We have lots of different views but come from the same principles. The principle for tax reform is get the cronyism out of the code, give people more power, lower rates, make us more competitive for faster growth of the and on health care, put the patient in charge," Ryan said. "Let she and her doctor be in charge of deciding their health care. Give people more choices, more insurance competition. And I believe these principles when applied to this problem offer better solutions. And I think, again, whoever one of these three become our nominee, I think they're going to be comfortable with this. So I'm really not that worried about it."

Appearing on CNN's "New Day" earlier, Ryan was similarly asked whether his effort, buttressed by a series of television appearances and speeches, including one to Georgetown University later Wednesday, was made complicated by Trump's lack of cohesion to some of the tenets of his policy platform.

"In fact, he is quite at odds with it. He wants Social Security as is, raise taxes on the wealthiest people," host Alisyn Camerota remarked.

"Well, we can get into details, but I think on the big things, whoever our nominee will be, I believe is going to be comfortable with the direction we're going," Ryan said. "We're talking about ideas and principles and policies that unify us."

Those include tax reform, government accountability and restoring constitutional congressional powers, Ryan said.

"These are things that everyone running for president, whether it's Donald Trump or John Kasich or Ted Cruz are all talking about, different variations of the same theme, but this is something that unifies all of us," he continued. "I'm comfortable, and by the way, I've spoken to all of these men."

"So I feel like we will be to be able to unify Republicans and conservatives to offer the country this fall a very clear and compelling choice so that the people of this nation get to decide where we go as a country," Ryan said.

Asked whether Trump told him in his phone call with the candidate that he was comfortable with that vision for the party, Ryan affirmed.

"Yeah, I said here is what we're doing, here's where we're going, here's why we're doing it. we decided this last year before the presidential election got even started," he concluded. "And yes, we had a very pleasant conversation."