A Curtin man has faced court in connection with a police seizure of about 28 kilograms of methylamphetamine, also known as ice, during the search of a car in Canberra's inner south.

ACT Policing said the seizure was the ACT's largest drug bust.

Alexander Scott Hagan, 51, has briefly appeared in the ACT Magistrates Court today charged with trafficking in a large commercial quantity of methylamphetamine.

He did not apply for bail and was remanded in custody until next week.

Detective Sergeant Shane Scott said about 1:30pm (AEDT) on Thursday officers found the drug in the car's boot and hidden within the bodywork.

"It is believed the 28 kilograms of drugs were destined to be shipped out of the ACT to the Victorian illicit drug market," he said.

"This amount of drugs could equate to 280,000 street deals valued at over $25 million."

Police said they found the drug in the boot and hidden within the bodywork of the car. ( Supplied: ACT Policing )

Five other search warrants were then executed across four houses in the suburbs of Curtin, Lyons, Holder and Conder, and one commercial property in Civic.

Police seized one kilogram of methylamphetamine, 500 tablets of suspected MDMA, approximately 28 grams of cocaine, a sum of cash and a small amount of steroids.

Detective Sergeant Scott said more arrests were likely.

"This investigation highlights the success of ACT Policing's drug and organised crime team and our commitment to investigating, pursuing and prosecuting those involved in the large scale supply of drugs into both the ACT market and interstate," he said.