LONDON — Reynolds American, the tobacco giant, said on Tuesday that it had agreed to sell the rights to its Natural American Spirit brand of cigarettes outside the United States and its territories to Japan Tobacco Group for about $5 billion in cash.

Reynolds American, whose brands include Camel, Newport and Pall Mall, will retain the rights to the Natural American Spirit brand in the United States, but will sell the international rights and associated trademarks as part of the deal. The United States rights will be held by Santa Fe Natural Tobacco Company, a Reynolds American subsidiary.

The transaction came on the heels of Reynolds American, based in Winston-Salem, N.C., completing its $25 billion acquisition of its smaller tobacco rival Lorillard this year. The deal was agreed to last year, including selling some products to Imperial Tobacco Group of Britain to gain regulatory approval.

Susan M. Cameron, Reynolds American’s president and chief executive, said the sale would allow the company to focus on increasing the sales of its brands within the United States.