A search is under way for two men who repeatedly rammed a stolen car into a high-end CBD fashion retailer before taking off with what is likely to be thousands of dollars' worth of stock.

Police were called to the Brisbane CBD Louis Vuitton store just before 4am Thursday after reports of the incident and arrived to find the Edward Street entry smashed in with items strewn across the floor.

Police say the two men, with their faces covered, repeatedly reversed a stolen BMW wagon into the doors before one jumped out and loaded handbags, which sell for thousands of dollars each, into the car.

The burnt-out vehicle was later found in Tiffany Street, Browns Plains, about 22km south of the Brisbane CBD.

At this stage, it is unclear how much stock was stolen or what the value of the items was.

Detectives are appealing for anyone who may have witnessed, or have dashcam footage of, the event to come forward.