Ukraine’s government confirmed that a Malaysia Airlines passenger airline crashed in eastern Ukraine late this afternoon, close to the Russian border.

The plane was carrying 295 people on board, according to Interfax news agency, including 280 passengers and 15 crew members. The flight departed at 12:14 p.m. from Amsterdam en route to Kuala Lumpur, and was reportedly shot down around 4:20 p.m. It is presumed that all 295 people are dead, according to Ukrainian Interior Ministry spokesman Anton Gerashchenko.