This article is cited by 100 publications.

Sebastian Planer, Paweł Małecki, Bartosz Trzaskowski, Anna Kajetanowicz, Karol Grela . Sterically Tuned N-Heterocyclic Carbene Ligands for the Efficient Formation of Hindered Products in Ru-Catalyzed Olefin Metathesis. ACS Catalysis 2020 , Article ASAP.

Hideaki Yano, Pramisha Adhikari, Sett Naing, Alexander F. Hoffman, Michael H. Baumann, Carl R. Lupica, Lei Shi . Positive Allosteric Modulation of the 5-HT1A Receptor by Indole-Based Synthetic Cannabinoids Abused by Humans. ACS Chemical Neuroscience 2020 , 11 (10) , 1400-1405. 11 (10) , 1400-1405. https://doi.org/10.1021/acschemneuro.0c00034

Adam Worob, Cody Wenthur . DARK Classics in Chemical Neuroscience: Synthetic Cannabinoids (Spice/K2). ACS Chemical Neuroscience 2019 , Article ASAP.

Paweł Małecki, Katarzyna Gajda, Roman Gajda, Krzysztof Woźniak, Bartosz Trzaskowski, Anna Kajetanowicz, Karol Grela . Specialized Ruthenium Olefin Metathesis Catalysts Bearing Bulky Unsymmetrical NHC Ligands: Computations, Synthesis, and Application. ACS Catalysis 2019 , 9 (1) , 587-598. 9 (1) , 587-598. https://doi.org/10.1021/acscatal.8b04783

Francesco Spinelli, Elena Capparelli, Carmen Abate, Nicola A. Colabufo, and Marialessandra Contino . Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies. Journal of Medicinal Chemistry 2017 , 60 (24) , 9913-9931. 60 (24) , 9913-9931. https://doi.org/10.1021/acs.jmedchem.7b00155

Mitchell Longworth, Samuel D. Banister, Rochelle Boyd, Richard C. Kevin, Mark Connor, Iain S. McGregor, and Michael Kassiou . Pharmacology of Cumyl-Carboxamide Synthetic Cannabinoid New Psychoactive Substances (NPS) CUMYL-BICA, CUMYL-PICA, CUMYL-5F-PICA, CUMYL-5F-PINACA, and Their Analogues. ACS Chemical Neuroscience 2017 , 8 (10) , 2159-2167. 8 (10) , 2159-2167. https://doi.org/10.1021/acschemneuro.7b00267

Annelies Cannaert, Florian Franz, Volker Auwärter, and Christophe P. Stove . Activity-Based Detection of Consumption of Synthetic Cannabinoids in Authentic Urine Samples Using a Stable Cannabinoid Reporter System. Analytical Chemistry 2017 , 89 (17) , 9527-9536. 89 (17) , 9527-9536. https://doi.org/10.1021/acs.analchem.7b02552

Mitchell Longworth, Mark Connor, Samuel D. Banister, and Michael Kassiou . Synthesis and Pharmacological Profiling of the Metabolites of Synthetic Cannabinoid Drugs APICA, STS-135, ADB-PINACA, and 5F-ADB-PINACA. ACS Chemical Neuroscience 2017 , 8 (8) , 1673-1680. 8 (8) , 1673-1680. https://doi.org/10.1021/acschemneuro.7b00116

Craig W. Lindsley ( Editor-in-Chief ). ACS Chemical Neuroscience: Most Cited Papers from 2015. ACS Chemical Neuroscience 2017 , 8 (8) , 1633-1634. 8 (8) , 1633-1634. https://doi.org/10.1021/acschemneuro.7b00246

Annelies Cannaert, Jolien Storme, Florian Franz, Volker Auwärter, and Christophe P. Stove . Detection and Activity Profiling of Synthetic Cannabinoids and Their Metabolites with a Newly Developed Bioassay. Analytical Chemistry 2016 , 88 (23) , 11476-11485. 88 (23) , 11476-11485. https://doi.org/10.1021/acs.analchem.6b02600

Samuel D. Banister, Mitchell Longworth, Richard Kevin, Shivani Sachdev, Marina Santiago, Jordyn Stuart, James B. C. Mack, Michelle Glass, Iain S. McGregor, Mark Connor, and Michael Kassiou . Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues. ACS Chemical Neuroscience 2016 , 7 (9) , 1241-1254. 7 (9) , 1241-1254. https://doi.org/10.1021/acschemneuro.6b00137

Takeshi Okada, Kazunori Nobushige, Tetsuya Satoh, and Masahiro Miura . Ruthenium-Catalyzed Regioselective C–H Bond Acetoxylation on Carbazole and Indole Frameworks. Organic Letters 2016 , 18 (5) , 1150-1153. 18 (5) , 1150-1153. https://doi.org/10.1021/acs.orglett.6b00268

Samuel D. Banister, Michael Moir, Jordyn Stuart, Richard C. Kevin, Katie E. Wood, Mitchell Longworth, Shane M. Wilkinson, Corinne Beinat, Alexandra S. Buchanan, Michelle Glass, Mark Connor, Iain S. McGregor, and Michael Kassiou . Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA. ACS Chemical Neuroscience 2015 , 6 (9) , 1546-1559. 6 (9) , 1546-1559. https://doi.org/10.1021/acschemneuro.5b00112

Erin E. Cawston, Mark Connor, Vincenzo Di Marzo, Romano Silvestri, and Michelle Glass . Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors. Journal of Medicinal Chemistry 2015 , 58 (15) , 5979-5988. 58 (15) , 5979-5988. https://doi.org/10.1021/acs.jmedchem.5b00579

Kristen R. Trexler, S. Olivia Vanegas, Justin L. Poklis, Steven G. Kinsey. The short-acting synthetic cannabinoid AB-FUBINACA induces physical dependence in mice. Drug and Alcohol Dependence 2020 , 214 , 108179. 214 , 108179. https://doi.org/10.1016/j.drugalcdep.2020.108179

Kenneth B. Walsh, Haley K. Andersen. Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling. International Journal of Molecular Sciences 2020 , 21 (17) , 6115. 21 (17) , 6115. https://doi.org/10.3390/ijms21176115

Keith Norman, Austin L. Ciesielski, Jarrad R. Wagner. Identification and associated hazards of clandestine drug laboratories. WIREs Forensic Science 2020 , 5 https://doi.org/10.1002/wfs2.1393

Daniel T. Baptista‐Hon, Mark Smith, Samuel Singleton, Lysbeth H. Antonides, Niamh Nic Daeid, Craig McKenzie, Tim G. Hales. Activation of μ‐opioid receptors by MT‐45 (1‐cyclohexyl‐4‐(1,2‐diphenylethyl)piperazine) and its fluorinated derivatives. British Journal of Pharmacology 2020 , 177 (15) , 3436-3448. 177 (15) , 3436-3448. https://doi.org/10.1111/bph.15064

Liesl Janssens, Annelies Cannaert, Matthew J. Connolly, Huiling Liu, Christophe P. Stove. In vitro activity profiling of Cumyl‐PEGACLONE variants at the CB 1 receptor: Fluorination versus isomer exploration. Drug Testing and Analysis 2020 , 24 24 https://doi.org/10.1002/dta.2870

Donna M Papsun, Alex J Krotulski, Joseph Homan, Keith D H Temporal, Barry K Logan. Flualprazolam Blood Concentrations in 197 Forensic Investigation Cases. Journal of Analytical Toxicology 2020 , 58 58 https://doi.org/10.1093/jat/bkaa070

Ahmed H.E. Hassan, Kyung Tae Park, Hye Jin Kim, Hyo Jong Lee, Yeong Ho Kwon, Ji Young Hwang, Choon-Gon Jang, Jin Hwa Chung, Ki Duk Park, Sang Joo Lee, Seung Jun Oh, Yong Sup Lee. Fluorinated CRA13 analogues: Synthesis, in vitro evaluation, radiosynthesis, in silico and in vivo PET study. Bioorganic Chemistry 2020 , 99 , 103834. 99 , 103834. https://doi.org/10.1016/j.bioorg.2020.103834

Vera L. Alves, João L. Gonçalves, Joselin Aguiar, Helena M. Teixeira, José S. Câmara. The synthetic cannabinoids phenomenon: from structure to toxicological properties. A review. Critical Reviews in Toxicology 2020 , 50 (5) , 359-382. 50 (5) , 359-382. https://doi.org/10.1080/10408444.2020.1762539

Monica Patel, Jamie J. Manning, David B. Finlay, Jonathan A. Javitch, Samuel D. Banister, Natasha L. Grimsey, Michelle Glass. Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists. Biochemical Pharmacology 2020 , 175 , 113871. 175 , 113871. https://doi.org/10.1016/j.bcp.2020.113871

Xiao‐Fei Wang, Ewa Galaj, Guo‐Hua Bi, Cindy Zhang, Yi He, Jia Zhan, Michael H. Bauman, Eliot L. Gardner, Zheng‐Xiong Xi. Different receptor mechanisms underlying phytocannabinoid‐ versus synthetic cannabinoid‐induced tetrad effects: Opposite roles of CB 1 /CB 2 versus GPR55 receptors. British Journal of Pharmacology 2020 , 177 (8) , 1865-1880. 177 (8) , 1865-1880. https://doi.org/10.1111/bph.14958

Dino Luethi, Matthias E. Liechti. Designer drugs: mechanism of action and adverse effects. Archives of Toxicology 2020 , 94 (4) , 1085-1133. 94 (4) , 1085-1133. https://doi.org/10.1007/s00204-020-02693-7

Paul Gray, Rob Ralphs, Lisa Williams. The use of synthetic cannabinoid receptor agonists (SCRAs) within the homeless population: motivations, harms and the implications for developing an appropriate response. Addiction Research & Theory 2020 , 34 , 1-10. 34 , 1-10. https://doi.org/10.1080/16066359.2020.1730820

Chris S. Breivogel, Jacob R. Wells, Amreen Jonas, Artik H. Mistry, Morgan L. Gravley, Rajul M. Patel, Brianna E. Whithorn, Bonnie M. Brenseke. Comparison of the Neurotoxic and Seizure-Inducing Effects of Synthetic and Endogenous Cannabinoids with Δ 9 -Tetrahydrocannabinol. Cannabis and Cannabinoid Research 2020 , 5 (1) , 32-41. 5 (1) , 32-41. https://doi.org/10.1089/can.2019.0003

Sabrina Jones, Azure L. Yarbrough, William E. Fantegrossi, Paul L. Prather, John M. Bush, Anna Radominska‐Pandya, Ryoichi Fujiwara. Identifying cytochrome P450s involved in oxidative metabolism of synthetic cannabinoid N ‐(adamantan‐1‐yl)‐1‐(5‐fluoropentyl)‐1 H ‐indole‐3‐carboxamide (STS‐135). Pharmacology Research & Perspectives 2020 , 8 (1) 8 (1) https://doi.org/10.1002/prp2.561

A. J. Potts, C. Cano, S. H. L. Thomas, S. L. Hill. Synthetic cannabinoid receptor agonists: classification and nomenclature. Clinical Toxicology 2020 , 58 (2) , 82-98. 58 (2) , 82-98. https://doi.org/10.1080/15563650.2019.1661425

Svetlana A. Appolonova, Covadonga Palacio, Ksenia M. Shestakova, Natalia V. Mesonzhnik, Alex Brito, Roman M. Kuznetsov, Pavel A. Markin, Natalia L. Bochkareva, Dmitry Burmykin, Maxim Ovcharov, Giacomo Musile, Franco Tagliaro, Sergey A. Savchuk. In vivo and in vitro metabolism of the novel synthetic cannabinoid 5F-APINAC. Forensic Toxicology 2020 , 38 (1) , 160-171. 38 (1) , 160-171. https://doi.org/10.1007/s11419-019-00503-z

Sabrine Bilel, Micaela Tirri, Raffaella Arfè, Andrea Ossato, Claudio Trapella, Giovanni Serpelloni, Margherita Neri, Liana Fattore, Matteo Marti. Novel halogenated synthetic cannabinoids impair sensorimotor functions in mice. NeuroToxicology 2020 , 76 , 17-32. 76 , 17-32. https://doi.org/10.1016/j.neuro.2019.10.002

Shivani Sachdev, Kiran Vemuri, Samuel D. Banister, Mitchell Longworth, Michael Kassiou, Marina Santiago, Alexandros Makriyannis, Mark Connor. In vitro determination of the efficacy of illicit synthetic cannabinoids at CB 1 receptors. British Journal of Pharmacology 2019 , 176 (24) , 4653-4665. 176 (24) , 4653-4665. https://doi.org/10.1111/bph.14829

Elise Wouters, Jolien Walraed, Samuel D. Banister, Christophe P. Stove. Insights into biased signaling at cannabinoid receptors: synthetic cannabinoid receptor agonists. Biochemical Pharmacology 2019 , 169 , 113623. 169 , 113623. https://doi.org/10.1016/j.bcp.2019.08.025

Sabrine Bilel, Micaela Tirri, Raffaella Arfè, Serena Stopponi, Laura Soverchia, Roberto Ciccocioppo, Paolo Frisoni, Sabina Strano-Rossi, Cristina Miliano, Fabio De-Giorgio, Giovanni Serpelloni, Anna Fantinati, Maria Antonietta De Luca, Margherita Neri, Matteo Marti. Pharmacological and Behavioral Effects of the Synthetic Cannabinoid AKB48 in Rats. Frontiers in Neuroscience 2019 , 13 13 https://doi.org/10.3389/fnins.2019.01163

Collin Tebo, Maryann Mazer-Amirshahi, Lindsey DeGeorge, Bradley Gelfand, Chikarlo Leak, Samantha Tolliver, Diane Sauter. Suspected synthetic cannabinoid receptor agonist intoxication: Does analysis of samples reflect the presence of suspected agents?. The American Journal of Emergency Medicine 2019 , 37 (10) , 1846-1849. 37 (10) , 1846-1849. https://doi.org/10.1016/j.ajem.2018.12.044

Michael Moir, Samuel Lane, Felcia Lai, Mark Connor, David E. Hibbs, Michael Kassiou. Strategies to develop selective CB2 receptor agonists from indole carboxamide synthetic cannabinoids. European Journal of Medicinal Chemistry 2019 , 180 , 291-309. 180 , 291-309. https://doi.org/10.1016/j.ejmech.2019.07.036

Abdullah Al-Matrouk, Mahasen Alqallaf, Adel AlShemmeri, Haider BoJbarah. Identification of synthetic cannabinoids that were seized, consumed, or associated with deaths in Kuwait in 2018 using GC–MS and LC–MS-MS analysis. Forensic Science International 2019 , 303 , 109960. 303 , 109960. https://doi.org/10.1016/j.forsciint.2019.109960

Kinga Kądzioła-Długołęcka, Oliwia Frączak, Beata Tkacz-Szczęsna, Ilona Kijewska, Radosław Wilczek, Krzysztof Makowski, Piotr Komorowski, Robert Bachliński, Anna Trynda, Bogdan Walkowiak. The paths of syntheses, chemical characteristics and stability tests for selected synthetic cannabinoids: 5F-PB-22, NM-2201, UR-144, and AB-CHMINACA. Australian Journal of Forensic Sciences 2019 , 293 , 1-12. 293 , 1-12. https://doi.org/10.1080/00450618.2019.1661515

David Fabregat‐Safont, Marie Mardal, Carolina Noble, Annelies Cannaert, Christophe P. Stove, Juan V. Sancho, Kristian Linnet, Félix Hernández, María Ibáñez. Comprehensive investigation on synthetic cannabinoids: Metabolic behavior and potency testing, using 5F‐APP‐PICA and AMB‐FUBINACA as model compounds. Drug Testing and Analysis 2019 , 11 (9) , 1358-1368. 11 (9) , 1358-1368. https://doi.org/10.1002/dta.2659

Andrej Grigoryev, Pierce Kavanagh, Andrew Labutin, Alexandr Pechnikov, Geraldine Dowling, Vadim Shevyrin, Natalia Krupina. Tentative identification of the metabolites of (1‐(cyclohexylmethyl)‐1 H ‐indol‐3‐yl)‐(2,2,3,3‐tetramethylcyclopropyl)methanone, and the product of its thermal degradation, by in vitro and in vivo methods. Drug Testing and Analysis 2019 , 11 (9) , 1387-1402. 11 (9) , 1387-1402. https://doi.org/10.1002/dta.2668

Samuel D. Banister, Richard C. Kevin, Lewis Martin, Axel Adams, Christa Macdonald, Jamie J. Manning, Rochelle Boyd, Michael Cunningham, Marc Y. Stevens, Iain S. McGregor, Michelle Glass, Mark Connor, Roy R. Gerona. The chemistry and pharmacology of putative synthetic cannabinoid receptor agonist (SCRA) new psychoactive substances (NPS) 5F‐PY‐PICA, 5F‐PY‐PINACA, and their analogs. Drug Testing and Analysis 2019 , 11 (7) , 976-989. 11 (7) , 976-989. https://doi.org/10.1002/dta.2583

Mitchell Longworth, Tristan A. Reekie, Karen Blakey, Rochelle Boyd, Mark Connor, Michael Kassiou. New-generation azaindole-adamantyl-derived synthetic cannabinoids. Forensic Toxicology 2019 , 37 (2) , 350-365. 37 (2) , 350-365. https://doi.org/10.1007/s11419-019-00466-1

Luke J. Ney, Allison Matthews, Raimondo Bruno, Kim L. Felmingham. Cannabinoid interventions for PTSD: Where to next?. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2019 , 93 , 124-140. 93 , 124-140. https://doi.org/10.1016/j.pnpbp.2019.03.017

Kyoko Hataoka, Asuka Kaizaki-Mitsumoto, Mika Takebayashi-Ohsawa, Natsumi Hattori, Masahiko Funada, Satoshi Numazawa. Hyperreflexia induced by XLR-11 smoke is caused by the pyrolytic degradant. Forensic Toxicology 2019 , 37 (2) , 412-423. 37 (2) , 412-423. https://doi.org/10.1007/s11419-019-00476-z

Husain A. Naqi, Timothy J. Woodman, Stephen M. Husbands, Ian S. Blagbrough. 19 F and 1 H quantitative-NMR spectroscopic analysis of fluorinated third-generation synthetic cannabinoids. Analytical Methods 2019 , 11 (24) , 3090-3100. 11 (24) , 3090-3100. https://doi.org/10.1039/C9AY00814D

João P Silva, Ana Margarida Araújo, Paula Guedes de Pinho, Helena Carmo, Félix Carvalho. Synthetic Cannabinoids JWH-122 and THJ-2201 Disrupt Endocannabinoid-Regulated Mitochondrial Function and Activate Apoptotic Pathways as a Primary Mechanism of In Vitro Nephrotoxicity at In Vivo Relevant Concentrations. Toxicological Sciences 2019 , 169 (2) , 422-435. 169 (2) , 422-435. https://doi.org/10.1093/toxsci/kfz050

Annukka Kallinen, Rochelle Boyd, Samuel Lane, Rajiv Bhalla, Karine Mardon, Damion H. R. Stimson, Eryn L. Werry, Roger Fulton, Mark Connor, Michael Kassiou. Synthesis and in vitro evaluation of fluorine-18 benzimidazole sulfones as CB2 PET-radioligands. Organic & Biomolecular Chemistry 2019 , 17 (20) , 5086-5098. 17 (20) , 5086-5098. https://doi.org/10.1039/C9OB00656G

Lysbeth H. Antonides, Annelies Cannaert, Caitlyn Norman, Loelia Vives, Aidan Harrison, Andrew Costello, Niamh Nic Daeid, Christophe P. Stove, Oliver B. Sutcliffe, Craig McKenzie. Enantiospecific Synthesis, Chiral Separation, and Biological Activity of Four Indazole-3-Carboxamide-Type Synthetic Cannabinoid Receptor Agonists and Their Detection in Seized Drug Samples. Frontiers in Chemistry 2019 , 7 https://doi.org/10.3389/fchem.2019.00321

Michael Kraemer, Anna Boehmer, Burkhard Madea, Alexandra Maas. Death cases involving certain new psychoactive substances: A review of the literature. Forensic Science International 2019 , 298 , 186-267. 298 , 186-267. https://doi.org/10.1016/j.forsciint.2019.02.021

Carolina Noble, Annelies Cannaert, Kristian Linnet, Christophe P. Stove. Application of an activity‐based receptor bioassay to investigate the in vitro activity of selected indole‐ and indazole‐3‐carboxamide‐based synthetic cannabinoids at CB1 and CB2 receptors. Drug Testing and Analysis 2019 , 11 (3) , 501-511. 11 (3) , 501-511. https://doi.org/10.1002/dta.2517

Annelies Cannaert, Marthe Vandeputte, Sarah M. R. Wille, Christophe P. Stove. Activity-based reporter assays for the screening of abused substances in biological matrices. Critical Reviews in Toxicology 2019 , 49 (2) , 95-109. 49 (2) , 95-109. https://doi.org/10.1080/10408444.2019.1576588

Samuel D. Banister, Axel Adams, Richard C. Kevin, Christa Macdonald, Michelle Glass, Rochelle Boyd, Mark Connor, Iain S. McGregor, Christopher M. Havel, Stephen J. Bright, Mireia Ventura Vilamala, Cristina Gil Lladanosa, Monica J. Barratt, Roy R. Gerona. Synthesis and pharmacology of new psychoactive substance 5F-CUMYL-P7AICA, a scaffold- hopping analog of synthetic cannabinoid receptor agonists 5F-CUMYL-PICA and 5F-CUMYL-PINACA. Drug Testing and Analysis 2019 , 11 (2) , 279-291. 11 (2) , 279-291. https://doi.org/10.1002/dta.2491

M. Krämer, A. Maas, B. Madea. Neue psychoaktive Substanzen im Kontext der Post-mortem-Toxikologie. Rechtsmedizin 2019 , 29 (1) , 51-63. 29 (1) , 51-63. https://doi.org/10.1007/s00194-018-0289-8

Jeremy Carlier, Ariane Wohlfarth, Bonita D. Salmeron, Karl B. Scheidweiler, Marilyn A. Huestis, Michael H. Baumann. Pharmacodynamic Effects, Pharmacokinetics, and Metabolism of the Synthetic Cannabinoid AM-2201 in Male Rats. Journal of Pharmacology and Experimental Therapeutics 2018 , 367 (3) , 543-550. 367 (3) , 543-550. https://doi.org/10.1124/jpet.118.250530

Mohammad Alkaseem, Mark Baron. SERS and DFT study of 5F-PB-22. Journal of Raman Spectroscopy 2018 , 49 (10) , 1594-1606. 49 (10) , 1594-1606. https://doi.org/10.1002/jrs.5444

Samuel K. Cordeiro, Ryan C. Daro, Hyunuk Seung, Wendy Klein-Schwartz, Hong K. Kim. Evolution of clinical characteristics and outcomes of synthetic cannabinoid receptor agonist exposure in the United States: analysis of National Poison Data System data from 2010 to 2015. Addiction 2018 , 113 (10) , 1850-1861. 113 (10) , 1850-1861. https://doi.org/10.1111/add.14281

Vincenzo Abbate, Michael Schwenk, Brandon C. Presley, Nahoko Uchiyama. The ongoing challenge of novel psychoactive drugs of abuse. Part I. Synthetic cannabinoids (IUPAC Technical Report). Pure and Applied Chemistry 2018 , 90 (8) , 1255-1282. 90 (8) , 1255-1282. https://doi.org/10.1515/pac-2017-0605

Jeremy Carlier, Xingxing Diao, Marilyn A. Huestis. Synthetic cannabinoid BB-22 (QUCHIC): Human hepatocytes metabolism with liquid chromatography-high resolution mass spectrometry detection. Journal of Pharmaceutical and Biomedical Analysis 2018 , 157 , 27-35. 157 , 27-35. https://doi.org/10.1016/j.jpba.2018.05.007

Samuel D. Banister, Alexander Olson, Matthew Winchester, Jordyn Stuart, Amelia R. Edington, Richard C. Kevin, Mitchell Longworth, Marco Herrera, Mark Connor, Iain S. McGregor, Roy R. Gerona, Michael Kassiou. The chemistry and pharmacology of synthetic cannabinoid SDB-006 and its regioisomeric fluorinated and methoxylated analogs. Drug Testing and Analysis 2018 , 10 (7) , 1099-1109. 10 (7) , 1099-1109. https://doi.org/10.1002/dta.2362

João P. Silva, Helena Carmo, Félix Carvalho. The synthetic cannabinoid XLR-11 induces in vitro nephrotoxicity by impairment of endocannabinoid-mediated regulation of mitochondrial function homeostasis and triggering of apoptosis. Toxicology Letters 2018 , 287 , 59-69. 287 , 59-69. https://doi.org/10.1016/j.toxlet.2018.01.023

Niki K. Burns, Trent D. Ashton, Paul G. Stevenson, James R. Pearson, I. Leona Fox, Frederick M. Pfeffer, Paul S. Francis, Zoe M. Smith, Neil W. Barnett, Lifen Chen, Jonathan M. White, Xavier A. Conlan. Extraction, identification and detection of synthetic cannabinoids found pre-ban in herbal products in Victoria, Australia. Forensic Chemistry 2018 , 7 , 19-25. 7 , 19-25. https://doi.org/10.1016/j.forc.2017.12.003

Joshua S. Elmore, Michael H. Baumann. Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats. Frontiers in Psychiatry 2018 , 9 https://doi.org/10.3389/fpsyt.2018.00055

Maiko Kusano, Kei Zaitsu, Kentaro Taki, Kazuaki Hisatsune, Jun'ichi Nakajima, Takako Moriyasu, Tomomi Asano, Yumi Hayashi, Hitoshi Tsuchihashi, Akira Ishii. Fatal intoxication by 5F-ADB and diphenidine: Detection, quantification, and investigation of their main metabolic pathways in humans by LC/MS/MS and LC/Q-TOFMS. Drug Testing and Analysis 2018 , 10 (2) , 284-293. 10 (2) , 284-293. https://doi.org/10.1002/dta.2215

Marie Mardal, Pieter Annaert, Carolina Noble, Marlies Oorts, Kristian Linnet. Metabolism of the synthetic cannabinoid 5F-PY-PICA by human and rat hepatocytes and identification of biliary analytical targets by directional efflux in sandwich-cultured rat hepatocytes using UHPLC-HR-MS/MS. Journal of Pharmaceutical and Biomedical Analysis 2018 , 149 , 296-307. 149 , 296-307. https://doi.org/10.1016/j.jpba.2017.11.027

Laura Hondebrink, Anne Zwartsen, Remco H.S. Westerink. Effect fingerprinting of new psychoactive substances (NPS): What can we learn from in vitro data?. Pharmacology & Therapeutics 2018 , 182 , 193-224. 182 , 193-224. https://doi.org/10.1016/j.pharmthera.2017.10.022

Samuel D. Banister, Mark Connor. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonists as New Psychoactive Substances: Origins. 2018 ,,, 165-190. ,, 165-190. https://doi.org/10.1007/164_2018_143

Samuel D. Banister, Mark Connor. The Chemistry and Pharmacology of Synthetic Cannabinoid Receptor Agonist New Psychoactive Substances: Evolution. 2018 ,,, 191-226. ,, 191-226. https://doi.org/10.1007/164_2018_144

Jebiti Haribabu, Dnyanesh S. Ranade, Nattamai S. P. Bhuvanesh, Prasad P. Kulkarni, Ramasamy Karvembu. Ru(II)- p -cymene Thiosemicarbazone Complexes as Inhibitors of Amyloid β (Aβ) Peptide Aggregation and Aβ-Induced Cytotoxicity. ChemistrySelect 2017 , 2 (35) , 11638-11644. 2 (35) , 11638-11644. https://doi.org/10.1002/slct.201702390

Charles W. Schindler, Benjamin R. Gramling, Zuzana Justinova, Eric B. Thorndike, Michael H. Baumann. Synthetic cannabinoids found in “spice” products alter body temperature and cardiovascular parameters in conscious male rats. Drug and Alcohol Dependence 2017 , 179 , 387-394. 179 , 387-394. https://doi.org/10.1016/j.drugalcdep.2017.07.029

Angeline S.Y. Tang, Samuel W.X. Loh, Hui Boon Koh, Sylvia Tan, Angeline T.W. Yap, Shu-Hua Zhang. Differentiation and identification of 5F-PB-22 and its isomers. Forensic Science International 2017 , 279 , 53-59. 279 , 53-59. https://doi.org/10.1016/j.forsciint.2017.08.009

Barry K. Logan, Amanda L.A. Mohr, Melissa Friscia, Alex J. Krotulski, Donna M. Papsun, Sherri L. Kacinko, Jeri D. Ropero-Miller, Marilyn A. Huestis. Reports of Adverse Events Associated with Use of Novel Psychoactive Substances, 2013–2016: A Review. Journal of Analytical Toxicology 2017 , 41 (7) , 573-610. 41 (7) , 573-610. https://doi.org/10.1093/jat/bkx031

Mohd Abdul Fatah Abdul Manan, David B. Cordes, Alexandra M. Z. Slawin, Michael Bühl, Vivian W. Y. Liao, Han. C. Chua, Mary Chebib, David O'Hagan. The Synthesis and Evaluation of Fluoro-, Trifluoromethyl-, and Iodomuscimols as GABA Agonists. Chemistry - A European Journal 2017 , 23 (45) , 10848-10852. 23 (45) , 10848-10852. https://doi.org/10.1002/chem.201701443

Shuji Kaneko. Motor vehicle collisions caused by the ‘super-strength’ synthetic cannabinoids, MAM-2201, 5F-PB-22, 5F-AB-PINACA, 5F-AMB and 5F-ADB in Japan experienced from 2012 to 2014. Forensic Toxicology 2017 , 35 (2) , 244-251. 35 (2) , 244-251. https://doi.org/10.1007/s11419-017-0369-6

Richard C. Kevin, Timothy W. Lefever, Rodney W. Snyder, Purvi R. Patel, Timothy R. Fennell, Jenny L. Wiley, Iain S. McGregor, Brian F. Thomas. In vitro and in vivo pharmacokinetics and metabolism of synthetic cannabinoids CUMYL-PICA and 5F-CUMYL-PICA. Forensic Toxicology 2017 , 35 (2) , 333-347. 35 (2) , 333-347. https://doi.org/10.1007/s11419-017-0361-1

Richard C Kevin, Katie E Wood, Jordyn Stuart, Andrew J Mitchell, Michael Moir, Samuel D Banister, Michael Kassiou, Iain S McGregor. Acute and residual effects in adolescent rats resulting from exposure to the novel synthetic cannabinoids AB-PINACA and AB-FUBINACA. Journal of Psychopharmacology 2017 , 31 (6) , 757-769. 31 (6) , 757-769. https://doi.org/10.1177/0269881116684336

, Andrew A. Monte, Diane P. Calello, Roy R. Gerona, Eike Hamad, Sharan L. Campleman, Jeffery Brent, Paul Wax, Robert G. Carlson. Characteristics and Treatment of Patients with Clinical Illness Due to Synthetic Cannabinoid Inhalation Reported by Medical Toxicologists: A ToxIC Database Study. Journal of Medical Toxicology 2017 , 13 (2) , 146-152. 13 (2) , 146-152. https://doi.org/10.1007/s13181-017-0605-9

Isabella Canazza, Andrea Ossato, Fabrizio Vincenzi, Adolfo Gregori, Fabiana Di Rosa, Federica Nigro, Alessandro Rimessi, Paolo Pinton, Katia Varani, Pier Andrea Borea, Matteo Marti. Pharmaco-toxicological effects of the novel third-generation fluorinate synthetic cannabinoids, 5F-ADBINACA, AB-FUBINACA, and STS-135 in mice. In vitro and in vivo studies. Human Psychopharmacology: Clinical and Experimental 2017 , 32 (3) , e2601. 32 (3) , e2601. https://doi.org/10.1002/hup.2601

Richard J. Hamilton, Vadim Keyfes, Sahil S. Banka. Synthetic Cannabinoid Abuse Resulting in ST-Segment Elevation Myocardial Infarction Requiring Percutaneous Coronary Intervention. The Journal of Emergency Medicine 2017 , 52 (4) , 496-498. 52 (4) , 496-498. https://doi.org/10.1016/j.jemermed.2016.09.023

Jeremy Carlier, Xingxing Diao, Cristina Sempio, Marilyn A. Huestis. Identification of New Synthetic Cannabinoid ADB-CHMINACA (MAB-CHMINACA) Metabolites in Human Hepatocytes. The AAPS Journal 2017 , 19 (2) , 568-577. 19 (2) , 568-577. https://doi.org/10.1208/s12248-016-0037-5

Anca Frinculescu, Catherine L. Lyall, John Ramsey, Bram Miserez. Variation in commercial smoking mixtures containing third-generation synthetic cannabinoids. Drug Testing and Analysis 2017 , 9 (2) , 327-333. 9 (2) , 327-333. https://doi.org/10.1002/dta.1975

Axel J. Adams, Samuel D. Banister, Lisandro Irizarry, Jordan Trecki, Michael Schwartz, Roy Gerona. “Zombie” Outbreak Caused by the Synthetic Cannabinoid AMB-FUBINACA in New York. New England Journal of Medicine 2017 , 376 (3) , 235-242. 376 (3) , 235-242. https://doi.org/10.1056/NEJMoa1610300

Andrew A. Monte. Synthetic Cannabinoid Receptor Agonists. 2017 ,,, 1609-1616. ,, 1609-1616. https://doi.org/10.1007/978-3-319-17900-1_42

Chiara Zanato, Alessia Pelagalli, Katie F. M. Marwick, Monica Piras, Sergio Dall'Angelo, Andrea Spinaci, Roger G. Pertwee, David J. A. Wyllie, Giles E. Hardingham, Matteo Zanda. Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers. Organic & Biomolecular Chemistry 2017 , 15 (9) , 2086-2096. 15 (9) , 2086-2096. https://doi.org/10.1039/C6OB02796B

Asuka Kaizaki-Mitsumoto, Kyoko Hataoka, Masahiko Funada, Yuki Odanaka, Hiroki Kumamoto, Satoshi Numazawa. Pyrolysis of UR-144, a synthetic cannabinoid, augments an affinity to human CB1 receptor and cannabimimetic effects in mice. The Journal of Toxicological Sciences 2017 , 42 (3) , 335-341. 42 (3) , 335-341. https://doi.org/10.2131/jts.42.335

Shuji Kaneko. Acute drug consumption and motor vehicle collision: A systematic review of 96 cases in Japan 2012-2014. Japanese Journal of Forensic Science and Technology 2017 , 22 (2) , 49-59. 22 (2) , 49-59. https://doi.org/10.3408/jafst.r019

Rachelle Abouchedid, James H. Ho, Simon Hudson, Alison Dines, John R. H. Archer, David M. Wood, Paul I. Dargan. Acute Toxicity Associated with Use of 5F-Derivations of Synthetic Cannabinoid Receptor Agonists with Analytical Confirmation. Journal of Medical Toxicology 2016 , 12 (4) , 396-401. 12 (4) , 396-401. https://doi.org/10.1007/s13181-016-0571-7

Graham McIlroy, Loretta Ford, Jawad M. Khan. Acute myocardial infarction, associated with the use of a synthetic adamantyl-cannabinoid: a case report. BMC Pharmacology and Toxicology 2016 , 17 (1) 17 (1) https://doi.org/10.1186/s40360-016-0045-1

Takahiro Doi, Akiko Asada, Akihiro Takeda, Takaomi Tagami, Munehiro Katagi, Hiroe Kamata, Yoshiyuki Sawabe. Enantioseparation of the carboxamide-type synthetic cannabinoids N -(1-amino-3-methyl-1-oxobutan-2-yl)-1-(5-fluoropentyl)-1 H -indazole-3-carboxamide and methyl [1-(5-fluoropentyl)-1 H -indazole-3-carbonyl]-valinate in illicit herbal products. Journal of Chromatography A 2016 , 1473 , 83-89. 1473 , 83-89. https://doi.org/10.1016/j.chroma.2016.10.049

Andreas Carlsson, Sandra Lindberg, Xiongyu Wu, Simon Dunne, Martin Josefsson, Crister Åstot, Johan Dahlén. Prediction of designer drugs: synthesis and spectroscopic analysis of synthetic cannabinoid analogues of 1 H -indol-3-yl(2,2,3,3-tetramethylcyclopropyl)methanone and 1 H -indol-3-yl(adamantan-1-yl)methanone. Drug Testing and Analysis 2016 , 8 (10) , 1015-1029. 8 (10) , 1015-1029. https://doi.org/10.1002/dta.1904

Markus R. Meyer. New psychoactive substances: an overview on recent publications on their toxicodynamics and toxicokinetics. Archives of Toxicology 2016 , 90 (10) , 2421-2444. 90 (10) , 2421-2444. https://doi.org/10.1007/s00204-016-1812-x

Willard J. Costain, Joseph S. Tauskela, Ingrid Rasquinha, Tanya Comas, Melissa Hewitt, Vincent Marleau, Evelyn C. Soo. Pharmacological characterization of emerging synthetic cannabinoids in HEK293T cells and hippocampal neurons. European Journal of Pharmacology 2016 , 786 , 234-245. 786 , 234-245. https://doi.org/10.1016/j.ejphar.2016.05.040

Line Marie Nielsen, Niels Bjerre Holm, Lars Olsen, Kristian Linnet. Cytochrome P450-mediated metabolism of the synthetic cannabinoids UR-144 and XLR-11. Drug Testing and Analysis 2016 , 8 (8) , 792-800. 8 (8) , 792-800. https://doi.org/10.1002/dta.1860

Shun-Jiang Yao, Zhi-Hui Ren, Zheng-Hui Guan. Recent advances on the synthesis of acylindoles. Tetrahedron Letters 2016 , 57 (35) , 3892-3901. 57 (35) , 3892-3901. https://doi.org/10.1016/j.tetlet.2016.07.063

Cornelius Hess, Clara T. Schoeder, Thanigaimalai Pillaiyar, Burkhard Madea, Christa E. Müller. Pharmacological evaluation of synthetic cannabinoids identified as constituents of spice. Forensic Toxicology 2016 , 34 (2) , 329-343. 34 (2) , 329-343. https://doi.org/10.1007/s11419-016-0320-2

Jeremy Carlier, Karl B. Scheidweiler, Ariane Wohlfarth, Bonita D. Salmeron, Michael H. Baumann, Marilyn A. Huestis. Quantification of [1-(5-fluoropentyl)-1H-indol-3-yl](naphthalene-1-yl)methanone (AM-2201) and 13 metabolites in human and rat plasma by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 2016 , 1451 , 97-106. 1451 , 97-106. https://doi.org/10.1016/j.chroma.2016.05.020

Dimitri Gerostamoulos, Simon Elliott, H. Chip Walls, Frank T. Peters, Matthew Lynch, Olaf H. Drummer. To Measure or Not to Measure? That is the NPS Question. Journal of Analytical Toxicology 2016 , 40 (4) , 318-320. 40 (4) , 318-320. https://doi.org/10.1093/jat/bkw013

Torbjörn U. C. Järbe, Jimit Girish Raghav. Tripping with Synthetic Cannabinoids (“Spice”): Anecdotal and Experimental Observations in Animals and Man. 2016 ,,, 263-281. ,, 263-281. https://doi.org/10.1007/7854_2016_16

Jenny L. Wiley, Julie A. Marusich, Brian F. Thomas. Combination Chemistry: Structure–Activity Relationships of Novel Psychoactive Cannabinoids. 2016 ,,, 231-248. ,, 231-248. https://doi.org/10.1007/7854_2016_17

Andrew A. Monte. Cannabinoid Receptor Agonists. 2016 ,,, 1-8. ,, 1-8. https://doi.org/10.1007/978-3-319-20790-2_42-1