Speed limits along Manhattan’s West Side Highway south of 59th Street will drop from 35 to 30 mph this weekend, city and state officials announced.

The change comes in response to a spate of traffic fatalities along the highway’s eight lanes of traffic, which separate the West Side from waterfront amenities including Chelsea Piers, Battery Park City and the West Side bike path.

Ten people — three pedestrians, two cyclists and five people in cars — have been killed there since 2013, and an average of 300 per year are injured.

“Adjusting speed limits to safer travel speeds has been among the keys to saving lives,” city Transportation Commissioner Polly Trottenberg said in a statement Thursday. “The old ‘West Side Highway’ is now more boulevard than highway — and this new speed limit reflects that evolution.”

The new speed limit goes into effect Saturday and will be enforced by NYPD and automated cameras.

The speed limit above 59th Street, where the surface-level road transitions into a full-blown elevated highway, remains at 50 mph.