Testbiotech has today published an independent evaluation of data from feeding trials with rats that were conducted under the GRACE project funded by the EU Commission. The rats were fed over a period of 90 days with genetically engineered maize MON810, which produces an insecticidal protein. The results were published in October 2014 in the journal Archives of Toxicology. The authors conclude that there were no relevant observable toxicological effects. However, an evaluation by Testbiotech has now revealed indications of negative health impacts on kidneys, liver and pancreas. Furthermore, the failure in this study to determine a concentration of MON810 at which there were no observable toxic effects, makes the entire study more or less invalid. For the evaluation of the data, additional external expertise was made available by a toxicologist with long-term experience in regulatory toxicology.

Testbiotech also criticizes the authors purposely published the results of the study in a scientific journal with close affiliation to industry. One could assume that this journal was deliberately chosen to avoid a rigorous examination of the data.

“We are shocked by the outcome of our own evaluation. According to the EU Commission, the outcome of these feeding studies will be decisive for future standards of risk assessment for genetically engineered plants in the EU. Now it looks as though the outcome was manipulated to eradicate doubts concerning the safety of these products”, says Christoph Then for Testbiotech

Amongst other things, Testbiotech can show that the leading editors of Archives of Toxicology, Jan G. Hengstler and Hermann Bolt have a close affiliation with industry and a similar position to industry when it comes to the risk assessment of chemicals. Also, the lead author of the GRACE study, Pablo Steinberg, has active collaborations with industry-funded institutions such as the International Life Science Institute (ILSI), furthermore he is one of the editors of Archives of Toxicology.

Given the importance of this study, Testbiotech recommends the retraction of the paper. Re-publication should only be considered under a rigorous peer review process, in a journal with a scientific reputation not tarnished by questionable cooperation with industry, which is not impacted by affiliations to the authors and has the highest standards regarding avoidance of conflicts of interest.

“If toxicological studies are publicly funded we must demand the highest standards in scientific quality and in the avoidance of conflicts of interest. This is not the case with this project. This case shows that the mechanisms for securing quality in scientific work are not functioning”, says Christoph Then.