Ted Cruz on Friday was forced to deny rumors that he has had multiple extramarital affairs, after the National Enquirer posted a report alleging the Texas senator cheated on his wife with five separate women.

Cruz called the report a "tabloid smear" he claimed was spread by GOP front-runner Donald Trump. Cruz has been feuding with Trump for the past few days over comments Trump made about his wife, Heidi.

"I want to be crystal clear: these attacks are garbage," Cruz wrote in a Facebook post on Friday afternoon. "For Donald J. Trump to enlist his friends at the National Enquirer and his political henchmen to do his bidding shows you that there is no low Donald won’t go."

"Trump may be a rat but I have no desire to copulate with him," @tedcruz said today in Oshkosh. #2016 pic.twitter.com/MkR8NdxN2P — Betsy Klein (@betsy_klein) March 25, 2016

Two of the five supposed mistresses have come out to vehemently deny the rumors, including Katrina Pierson — who supported Cruz in his 2012 Senate race but who is now a spokeswoman for Trump.

What's worse? People who actually believe the trash in tabloids, or the ones who know it's false &spread it anyway? #stupidity on all levels — Katrina Pierson (@KatrinaPierson) March 25, 2016

Another woman, former Cruz spokeswoman Amanda Carpenter, defended herself in a fiery exchange with a Trump supporter on CNN.

"It is categorically false," Carpenter said during the exchange. "You should be ashamed for spreading this kind of smut."

Trump denied being behind the National Enquirer's allegations, which were made by anonymous sources.

"I had absolutely nothing to do with it, did not know about it, and have not, as yet, read it," Trump said in a statement tweeted by CNN reporter Jeremy Diamond.

Trump did, however, threaten to "spill the beans" on Cruz's wife earlier this week in a tweet that began the latest feud between the two Republican presidential contenders.

Trump is also reportedly friends with the CEO of the National Enquirer.

The Enquirer has a reputation as a gossipy supermarket tabloid that invents stories, but it did report in 2007 that then-presidential candidate John Edwards was having an extramarital affair, and later named the woman involved — all of which turned out to be true.

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