Denver Public Schools is telling parents to expect delays Wednesday due to road closures and other backups related to the presidential debate at the University of Denver.

For security reasons, Interstate 25 will be closed in both directions from Santa Fe Drive to Hampden Avenue from 5 to 10 p.m. Wednesday.

But the travel equation is further complicated because oversize and overweight vehicles — including school buses — will not be allowed to travel on I-25 between Interstates 76 and 225 from 3 to 11 p.m. Also, large vehicles are prohibited from traveling on U.S. 85 between I-25 and Hampden and on Hampden between Santa Fe and I-25 from 3 to 10 p.m.

In emails to parents and on the district’s website, DPS warns there will be an impact to some school bus routes and there may be delays for after school pick-up and drop-off, extracurricular activities and athletic trips.

DPS spokesman Mike Vaughn said any additional changes will be updated immediately.

Vaughn said parents are asked to pick up their children from affected schools, if possible. DPS Transportation will dispatch drivers early to provide extra time to travel routes serving the following schools: Asbury Elementary School, Bradley International School, Cory Elementary, Grant Middle School, Hamilton Middle School, Holm Elementary, Merrill Middle School, McKinley-Thatcher Elementary School, Samuels Elementary, South High School, Southmoor Elementary, Slavens School, University Park Elementary School and Thomas Jefferson High School, according to the district website.

Ryan Parker: 303-954-2409, rparker@denverpost.com or twitter.com/ryanparkerdp