Former Queensland assistant health minister Chris Davis has resigned as the LNP Member for Stafford on Brisbane's northside.

Premier Campbell Newman has expressed disappointment at Dr Davis's decision, and says he is considering dates for a by-election.

Dr Davis has told 7.30 Queensland he decided not to cross the floor on donation laws on Thursday night because it was made clear that the LNP would not tolerate the move.

But he says he had been planning to vote against the bill.

"There was certainly no tolerance of it. There was very much advice to the contrary, and that put me in an intolerable position," he said.

Dr Davis was sacked as assistant health minister last week after he spoke out against doctor contracts and changes to the Crime and Misconduct Commission.

At that time, Mr Newman said Dr Davis was dismissed for breaching Cabinet solidarity, although the Premier also called him a man of great integrity.

Dr Davis told the House on Thursday night he could not support his Government's move that only political donations of more than $12,400 would have to be declared to the electoral commission.

But he was conspicuously absent when the legislation was put to a vote.

Dr Davis said on Friday it was "with sadness that I have advised the Speaker of my resignation".

"The passage of recent Government legislation affecting critical aspects of our democracy goes contrary to my value system and that of the majority of my electorate," he said in a statement on his website.

"I would never have stood for Parliament on such a platform, nor do I believe I would have been elected.

"My most recent speech to Parliament offers additional insights. My sacking has been a catalyst."

Premier says Dr Davis should serve out his term

Mr Newman responded to the decision by suggesting he disagreed with Dr Davis's decision to quit.

"He hasn't called me and I just make that point that I'm afraid this speaks volumes about what's been going on," Mr Newman said.

"I'm disappointed because I would have liked to have him stay on in the team, and I'm disappointed for the people of Stafford.

"I think it's appropriate that people resign from Parliament if they have health issues or if they have family issues, that's understandable.

"But we all have a duty to serve out our term if we don't have those sorts of issues confronting us."

But Dr Davis said it was no longer possible for him to represent his electorate in such an environment, "despite my best endeavours".

"I thank the people of Stafford for the opportunity to have served them," he said.

"It has been an honour and a privilege, and I look forward to ongoing engagement with such a wonderful community.

"I also thank everyone who has helped and guided me on this journey, particularly my family and my electorate team."

On Tuesday, Deputy Premier Jeff Seeney had said Dr Davis would remain in the LNP, after a party room meeting discussed the matter.

Mr Seeney said Dr Davis got a dressing down at the party room meeting and had apologised.

Dr Davis said then he would remain the LNP's Member for Stafford and he would contest the next state election.

'Vote of no confidence'

Opposition Leader Annastacia Palaszczuk says the Member for Stafford's resignation is a condemnation of the Premier and his policies.

"Today there has been a vote of no confidence in Campbell Newman and his leadership," she said.

"This Government is arrogant, it's out of touch, it's not listening.

"The member for Stafford has dramatically resigned after a turbulent week in Parliament.

"We need to restore honesty and integrity back into Queensland."

Mr Newman says he has two potential LNP candidates in mind for Stafford.

Ms Palaszczuk says Labor has already endorsed surgeon Anthony Lynham as its candidate.

"It'll be a tough battle, but I sense a deep sea of unrest," she said.