PORTLAND, Ore. - Vaping products, one of the fastest-growing segments of the legal marijuana industry, have taken a hit from consumers as public health experts scramble to determine what’s causing a mysterious and sometimes fatal lung disease among people who use e-cigarettes.

The ailment has sickened at least 805 people and killed 12. Some vaped nicotine, but many reported using oil containing THC, marijuana’s high-inducing ingredient, and said they bought products from pop-up shops and other illegal sellers. The only death linked to THC vapes bought at legal shops occurred in Oregon.

Amid the health scare, the amount of the legal pot industry’s revenue that comes from vape products has dropped by 15% nationwide, with some states, including Oregon, seeing decreases of more than 60%.

Health officials in California, home to the world’s largest legal marijuana marketplace, this week issued an advisory urging people to stop all forms of vaping until a cause is determined. Massachusetts, which like California allows so-called recreational use of marijuana by people 21 and older, went further than any other state, issuing a four-month ban on vape sales.

Vaping THC is popular for those desiring quick high without the smoke that comes from lighting up joints. Marijuana companies are trying to boost the public’s confidence by promoting that their vaping products are tested by the government, demanding ingredient lists from their vendors and in some cases pulling items from shelves. Some also are scrambling to get liability insurance.

Still, many have seen notable declines in sales in the few weeks since the health scare emerged on a national scale.

“It’s having an impact on how consumers are behaving,” said David Alport, owner of Bridge City Collective in Portland, which in two weeks saw a 31% drop in sales of vape cartridges that hold the oil that vaporizes when heated. “People are concerned, and we’re concerned.”

In the United States’ booming legal cannabis market, vaping products have exploded in popularity. In roughly two years, they have grown from a small fraction of overall sales to about one-third, with $9.6 billion in sales between 2017 and 2019, according to New Frontier Data, an economic analysis firm that tracks the industry. About one-fifth of U.S. cannabis consumers report using them.

New Frontier found a 15% decline in the market share for vape sales nationwide during the first week of September and saw no rebound in data collected through Sept. 18. At the state level, New Mexico, Massachusetts, Nevada and Montana all saw drops of one-third or more, while California fell by 6%.

Oregon, which announced its death at the beginning of the month and said it was from a vape purchased at a regulated dispensary, saw one of the biggest drops in market share for vape revenue —62%, said John Kagia, the firm’s chief knowledge officer.

But as vape sales sink, some retailers report sales of other cannabis products going up. Bridge City Collective, for example, saw its usually lacklustre edible sales increase about 40 per cent the same week vaping sales plummeted. Consumers also are showing more interest in the dried flower used in joints.

Analysts are watching to see if vape sales erode further after the U.S. Centers for Disease Control and Prevention announced Thursday that the number of suspected vaping-related illnesses had grown by 52 per cent in the past week.

“This is a very, very fast-moving issue, and it will likely be a couple more weeks, if not months, before we understand the impact it’s really had on the retail ecosystem and on consumers’ attitudes,” Kagia said prior to the announcement.

Doctors have said the illnesses resemble an inhalation injury, with the lungs apparently reacting to a caustic substance. So far, no single vaping product or ingredient has been linked to the illnesses.

Health officials in New York are focusing on vitamin E acetate, a viscous solution that’s sometimes added to marijuana oils. Retailers in some markets are pulling products from their shelves that contain that and other additives. Other companies have proactively released public statements saying their vape oils contain only pure THC.

Medicine Man, which operates five retail outlets in Colorado, announced Thursday it has stopped selling vape products with propylene glycol or vitamin E acetate.

“The decision to take this particular product off our shelves was significant, as the confidence and trust of our consumers is paramount to our core values,” Medicine Man President and Chief Executive Officer Sally Vander Veer said. “Hopefully the rest of the industry will also conclude that removing these cannabis products with the chemical additives under scrutiny from the market is in the best interest of consumers and all of us as operators.”

In Illinois, a message board for medical marijuana patients banned posters from sharing home vape recipes.

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“I just do THC. No flavour additives. I won’t even take that chance,” said Lisa Haywood, a medical marijuana card holder who lives outside Chicago and follows the board for advice and support.

State regulators track the cannabis sold to consumers but don’t monitor what additives are in marijuana oil vapes. That’s led states to begin discussions of how to tighten restrictions on vaping products even as retailers themselves try to determine which of the products on their shelves contain so-called cutting agents.

“We haven’t evolved our system that far to think about what we would test for in those products. A lot of these additives were conceptual at the time when the (marijuana legalization) law passed and the program came into place,” said Steve Marks, executive director of the Oregon Liquor License Commission, which oversees the state’s cannabis industry.

“Figuring that out is part of the evolution that we have to do as a consumer protection agency,” he said.

Hilary Bricken, a Los Angeles-based attorney whose firm specializes in cannabis business law and regulatory issues, said the legal marijuana industry is moving so fast that many states are “literally making this up as they go,” and the vaping scare has stripped away the sense of security that consumers get from buying from a licensed dispensary.

The vaping crisis will undoubtedly hasten tighter regulation at the state level and force the industry to patrol itself better to avoid crippling lawsuits, she said. The idea of more regulation unnerves some medical marijuana.

If there’s a ban, “what does it do for all these people who have been seeing relief? ... It is going to really impact patients and the industry that we’ve fought” to create, said Melanie Rose Rodgers, a Colorado medical cannabis patient and leader of the state’s chapter of Americans for Safe Access, which advocates for medical marijuana patients.

Bobby Burleson, an analyst with Toronto-based investment and financial services company Canaccord Genuity, said the initial problems for the vape segment of the cannabis industry should moderate, and the health scare may in the end help the legal marijuana industry.

The crisis “should ultimately accelerate the shift away from the black market for cannabis products in the U.S.,” he said.

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Flaccus and Peltz, who reported from New York City, are members of AP’s marijuana beat team. Follow the AP’s complete marijuana coverage: https://apnews.com/Marijuana .