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State Trooper motorcycle escort leads the Trail of Tears motorcycle riders pass through Huntsville,AL on I-565 Saturday morning Sept. 21, 2013. (Bob Gathany/bgathany@al.com)

HUNTSVILLE, Alabama-- The 21st Annual Trail of Tears Commemorative Motorcycle Ride will make it's way through the Tennessee Vally on Sept. 20.

The ride will come into Huntsville from Scottsboro on Highway 72 East. The route will continue west on Interstate 565 and merge right onto exit 3. It will then go north on Greenbrier Road and turn left to travel west on Old Highway 20 and stop at Rocket Harley-Davidson.

The ride will leave Rocket Harley-Davidson at 11:30 a.m. and continue west on Old Highway 20, turn right to travel north on Mooresville Road and continue to Highway 72 West.

All entrance ramps to travel westbound on I-565 will be closed for the safety of the riders in the event. Multiple law enforcement agencies will be assisting as the ride travels to and exits Huntsville.

Motorists traveling east or west on Highway 72 West can expect a lengthy delay between 11:45 a.m. and 12:30 p.m. as the ride makes the left turn to travel west onto Highway 72 toward Athens.

The Trail of Tears is a cooperative effort between the Alabama State Troopers and all law enforcement agencies, fire departments and ambulance services along the route to ensure a successful and safe event.